Test Method Evaluation Report: Review of In Vitro Endocrine Disruptor Screening Assays
ICCVAM Final Report: ICCVAM Evaluation of In Vitro Test Methods for Detecting Potential Endocrine Disruptors: Estrogen Receptor and Androgen Receptor Binding and Transcriptional Activation Assays
NIH Publication No: 03-4503
Full text of report May 2003
(Please note: This is a large document (8.6 Mb) and may take some time to open.)
Addendum September 2006
Table of Contents
- ICCVAM - NICEATM Overview
- Table of Contents
- List of Tables
- List of Abbreviations and Acronyms
- ICCVAM Representatives
- Acknowledgements
- Preface
- Executive Summary
- ICCVAM Evaluation and Recommendations on Estrogen and Androgen Receptor Binding and Transcriptional Activation Assays
- Introduction
- ICCVAM Proposed Substances for Validation of In Vitro Endocrine Disruptor Assays
- Public Comments
- ICCVAM Recommendations
- Proposed Substances and Selection Criteria for Validation of In Vitro Endocrine Disruptor Screening Assays
- Introduction
- Draft Background Review Document Recommendations
- Expert Panel Recommendations on Proposed Substances for Validation Studies
- ICCVAM, EDWG and NICEATM Proposed List of Substances for Validation
- In Vitro Estrogen Receptor Binding Assays
- Minimum Procedural Standards
- Recommended Substances for Validation of In Vitro Estrogen Receptor Binding Assays
- In Vitro Estrogen Receptor Transcriptional Activation Assays
- Minimum Procedural Standards
- Recommended Substances for Validation of In Vitro Estrogen Receptor Transcriptional Activation Assays
- In Vitro Androgen Receptor Binding Assays
- Minimum Procedural Standards
- Recommended Substances for Validation of In Vitro Androgen Receptor Binding Assays
- In Vitro Androgen Receptor Transcriptional Activation Assays
- Minimum Procedural Standards
- Recommended Substances for Validation of In Vitro Androgen Receptor Transcriptional Activation Assays
- References
Appendices
Appendix B: Evaluation Guidance to the Expert Panel for the Review of In Vitro Test Methods for Detecting Endocrine Disruptors
- Evaluation Guidance for Estrogen Receptor and Androgen Receptor Binding Assays
- Evaluation Guidance for Estrogen Receptor and Androgen Receptor Transcriptional Activation Assays
Appendix C: Expert Panel Evaluation Meeting Agenda
Appendix D: Expert Panel Meeting Minutes
Appendix E. ICCVAM Expert Panel Evaluation Federal Register Notices
- Request for Data and Nominations of Expert Scientists: 66 FR 16278, March 23, 2001
(No public comments received in response to this notice) - Notice of an Expert Panel Meeting and Request for Comments: 67 FR 16415, April 5, 2002
View public comments recieved in response to this notice - Announcing Availability of Expert Panel Report, Proposed List of Substances and Final Background Review Documents: 67 FR 64902, October 22, 2002
View public comments recieved in response to this notice