Reference Data for Evaluation of In Vitro Test Methods and Computational Models
NICEATM is compiling high-quality data from in vivo testing of chemicals for potential endocrine disruptor activity. These data have potential use for:
- Developing adverse outcome pathways or models of estrogenic activity
- Prioritizing chemicals for further testing
- Evaluating species-specific responses to chemicals
Curated Database of Rodent Uterotrophic Bioactivity
NICEATM searched the peer-reviewed literature for uterotrophic assay data on the 1812 ToxCast compounds. The uterotrophic assay (EPA OPPTS 890.1600) measures the estrogenic activity of a substance by assessing its effect on the weight of the uterus in a female rodent.
The initial search yielded over 1000 papers, of which 670 were potentially relevant based on the inclusion of uterine weight as a measured endpoint. From these 670 manuscripts, 2615 individual chemical/
Only study design protocols that met six minimum criteria were included in the Guideline-Like Uterotrophy Database (GL-UTDB). The GL-UTDB contains information from 458 guideline-like (GL) studies extracted from 93 publications, providing high-quality in vivo estrogenic bioactivity data on 118 chemicals with unique CASRNs (103 of which are in the ToxCast/
- View data from initial search: 2615 experiments
- View GL-UTDB
- Reference: Kleinstreuer NC, Ceger PC, Allen DG, Strickland J, Chang X, Hamm JT, Casey WM. A curated database of rodent uterotrophic bioactivity. Environ Health Perspect. 2016;124(5):556-562.