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Background Review Documents: In Vitro Ocular Test Methods

The "Complete Document" PDFs below may not be accessible to some readers. The individual sections of each document may provide improved accessibility.

Bovine Corneal Opacity and Permeability Test

Complete Document 

Front Matter

Main Body

  1. Introduction and Rationale for the Proposed Use of In Vitro Test Methods to Identify Ocular Corrosives and Severe Irritants
  2. BCOP Test Method Protocol Components
  3. Substances Used for Validation of the BCOP Test Method
  4. In Vivo Reference Data Used for an Assessment of Test Method Accuracy
  5. BCOP Test Method Data and Results
  6. BCOP Test Method Accuracy
  7. BCOP Test Method Reliability
  8. BCOP Test Method Data Quality
  9. Other Scientific Reports and Reviews
  10. Animal Welfare Considerations
  11. Practical Considerations
  12. References
  13. Glossary

Appendices

Hen's Egg Test - Chorioallantoic Membrane Test

Complete Document 

Front Matter

Main Body

  1. Introduction and Rationale for the Proposed Use of In Vitro Test Methods to Identify Ocular Corrosives and Severe Irritants
  2. Test Method Protocol Components
  3. Substances Used for Validation of the HET-CAM Test Method
  4. In Vivo Reference Data Used for an Assessment of Test Method Accuracy
  5. Test Method Data and Results
  6. Test Method Accuracy
  7. Test Method Reliability
  8. Test Method Data Quality
  9. Other Scientific Reports and Reviews
  10. Animal Welfare Considerations
  11. Practical Considerations
  12. References
  13. Glossary

Appendices

Isolated Chicken Eye Test

Complete Document 

Front Matter

Main Body

  1. Introduction and Rationale for the Proposed Use of In Vitro Test Methods to Identify Ocular Corrosives and Severe Irritants
  2. Test Method Protocol Components
  3. Substances Used for Validation of the ICE Test Method
  4. In Vivo Reference Data Used for an Assessment of Test Method Accuracy
  5. Test Method Data and Results
  6. Test Method Accuracy
  7. Test Method Reliability
  8. Test Method Data Quality
  9. Other Scientific Reports and Reviews
  10. Animal Welfare Considerations
  11. Practical Considerations
  12. References
  13. Glossary

Appendices

Isolated Rabbit Eye Test

Complete Document 

Front Matter

Main Body

  1. Introduction and Rationale for the Proposed Use of In Vitro Test Methods to Identify Ocular Corrosives and Severe Irritants
  2. IRE Test Method Protocol Components
  3. Substances Used for Validation of the IRE Test Method
  4. In Vivo Reference Data Used for an Assessment of Test Method Accuracy
  5. IRE Test Method Data and Results
  6. IRE Test Method Accuracy
  7. IRE Test Method Reliability
  8. Test Method Data Quality
  9. Other Scientific Reports and Reviews
  10. Animal Welfare Considerations
  11. Practical Considerations
  12. References
  13. Glossary

Appendices