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Request for Information (RFI): Input on a Literature Review Approach “Identifying Research Needs for Assessing Safe Use of High Intakes of Folic Acid”

RFI response period ended May 28, 2013

The National Toxicology Program ( NTP ) in conjunction with the NIH Office of Dietary Supplements (ODS) is planning a workshop to identify research needs based on consideration of the state of the science related to the safe use of high intakes of folic acid. The benefit of supplemental folic acid for pregnant women to prevent neural tube defects in their children is well established; at the same time, there is interest in understanding potential adverse health impacts from high intakes of folic acid. This project aims to identify research needs and inform the development of a research agenda for evaluating the safe use of high intakes of folic acid.

Due to the vastness of the research on folate and folic acid, screening of the literature was undertaken to identify the potential adverse health effects for which further research might be warranted. An approach document, “Identifying Research Needs for Assessing Safe Use of High Intakes of Folic Acid,” was referenced when responding to the RFI (link to pdf). This document (1) outlines the approach used to screen the literature, (2) describes the results of the screening effort, and (3) proposes a list of health outcomes for discussion at the workshop. As background for the workshop, a literature review document on these health outcomes will be prepared using systematic review methodology.

Responses to this RFI were received through May 28, 2013. Future updates on this project, including draft protocols for development of the literature review document, will be posted. Individuals interested in receiving updates on this project are encouraged to register to the NTP Listserv.

Federal Register Notice (PDF  HTML)

NIH Guide Notice

Please direct all inquiries to:
Abee L. Boyles, Ph.D.
Health Scientist
Office of Health Assessment and Translation
Division of the National Toxicology Program
National Institute of Environmental Health Sciences
111 TW Alexander Dr., PO Box 12233
MD: K2-04, Durham, NC 27709
Phone: (919) 541-7886
Fax: (301) 480-3230

Regan Bailey, Ph.D., R.D.
Nutritional Epidemiologist
Office of Dietary Supplements
National Institutes of Health
6100 Executive Blvd., Room 3B01
Bethesda, MD 20892-7517
Phone: (301) 496-0187
Fax: (301) 480-1845