National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/719247

Regulatory Actions for Year 1983




Environmental Protection Agency (EPA)

Notice Type Title Summary of Notice NTP Information Cited CASRN
Proposed Rule Hexafluoropropylene Oxide EPA proposed test rule under TSCA Section 4.

December 30, 1983 -- 48 FR 57686
NTP planning to conduct Ames assay. 428-59-1
Proposed Rule Cyromazine EPA issuance of emergency exemptions for use of an unregistered pesticide.

December 14, 1983 -- 48 FR 55624
Applicant's earlier request for specific exemption was denied because of results of NTP study of Melamine, a metabolite of Cyromazine. 108-78-1
Proposed Rule Chlorinated Benzenes EPA proposed rule to withdraw most testing requirements.

December 07, 1983 -- 48 FR 54836
NTP mutagenesis testing of Monochlorobenzene; 1,2,4-Trichlorobenzene and Pentachlorobenzene. NTP toxicity testing of Monochlorobenzene,ortho and para-Dichlorobenzenes. (TR-255) (TR-261) 120-82-1
108-90-7
608-93-5
95-50-1
Notice Formaldehyde EPA notice of reconsideration as to whether TSCA Section 4f priority consideration is appropriate.

November 18, 1983 -- 48 FR 52507
Federal Panel on Formaldehyde, formed by several agencies under the aegis of NTP, reviewed study of Formaldehyde. 50-00-0
Notice Bis(2-Ethylhexyl)Terephthalate; Response to the Interagency Testing Committee EPA notice that it is not initiating TSCA Section 4 test requirement rulemaking because ongoing tests are expected to provide sufficient information to predict toxicity.

November 14, 1983 -- 48 FR 51845
Two chemicals similar to metabolites of DOTP have been nominated for genotoxicity testing by the NTP. 104-76-7
4376-20-9
Notice Tris EPA notice that it is not initiating TSCA Section 4A test requirement rulemaking because ongoing tests are expected to provide sufficient information to predict toxicity.

November 14, 1983 -- 48 FR 51842
NTP testing of compounds containing the 2-ethylhexyl moiety. (TR-274) 78-42-2
Notice 4,4-Methylenedianiline EPA ANPR of EPA/OSHA joint initiation of regulatory action under TSCA and OSHA Act.

September 20, 1983 -- 48 FR 42898
NTP bioassay indicated that the dihydrochloride salt of 4,4-MDA is carcinogenic in both sexes of rats and mice. (TR-248) 13552-44-8
Notice 4,4-Methylenedianiline EPA notice that it is not initiating a TSCA Section 4A health effects test rule because recent NTP study shows MDA to be carcinogenic in rats and mice.

July 11, 1983 -- 48 FR 31806
The data from the NTP bioassay are sufficient...and further oncogenicity testing is unnecessary. (TR-248) 13552-44-8
Notice Formamide EPA notice of determination not to require additional health effects testing.

May 23, 1983 -- 48 FR 23098
NTP genotoxicity testing, together with importer's subchronic effects testing, make it unnecessary to require Section 4A testing. 75-12-7
Notice Isophorone EPA notice that it is not initiating TSCA Section 4A test requirements because of adequate ongoing tests.

January 06, 1983 -- 48 FR 727
NTP long-term bioassay, together with manufacturers' tests, make it unnecessary to require Section 4A testing. (TR-291) 78-59-1

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Occupational Safety and Health Administration (OSHA)

Notice Type Title Summary of Notice NTP Information Cited CASRN
Notice Hazard Communication OSHA final rule setting final occupational safety and health standard requiring hazard assessment and communication to employees of chemical hazard information.

November 25, 1983 -- 48 FR 53280
For purposes of hazard communication, OSHA defines a carcinogen as any substance found to be a confirmed or suspected carcinogen by NTP, IARC, or OSHA itself. N/A
Notice Asbestos OSHA emergency temporary standard to reduce occupational PEL.

November 04, 1983 -- 48 FR 51086
NTP studies in which Chrysotile, Amosite, Tremolite, and Crocidolite in feed were administered to lab animals with no increased incidence of tumors. 12001-28-4
12001-29-5
12172-73-5
14567-73-8
1332-21-4
Notice Ethylene Dibromide OSHA NPRM to revise current occupational exposure standard to reduce PEL, restrict dermal exposure, etc.

October 07, 1983 -- 48 FR 45956
NTP/NCI inhalation bioassay concluded that EDB was carcinogenic to rats. (TR-210) 106-93-4

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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.