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Regulatory Actions for Year 1984


Environmental Protection Agency (EPA)

Notice Type Title Summary of Notice NTP Information Cited CASRN
Proposed Rule Certain Polyamino Chemical Substances EPA proposed rule promulgating a significant new use rule under TSCA Section 5.

December 27, 1984 -- 49 FR 50209
NTP bioassay indicated that the dihydrochloride salt of Methylenedianiline is carcinogenic in both sexes of rats and mice. (TR-248) 13552-44-8
Proposed Rule [(Dinitrophenyl)Azo]-[2,4-Diamino-5-Methoxybenzene] Derivatives; Proposed Determination of Significant New Uses EPA proposed rule promulgating a significant new use rule under TSCA Section 5.

October 25, 1984 -- 49 FR 42960
NTP and others have shown carcinogenic potential of close structural analogues of phenylenediamines.
Final Rule 1,1,1-Trichloroethane EPA final rule identifying specific chemical substance and mixture testing requirements.

October 10, 1984 -- 49 FR 39810
EPA did not propose chronic effects or oncogenicity testing because an NTP study is expected to provide sufficient information. (TR-262) 71-55-6
Proposed Rule Dichloromethane EPA proposed rule to withdraw testing requirements under TSCA. Evaluation of data indicates dichloromethane does not present unreasonable risks.

June 19, 1984 -- 49 FR 25009
EPA expects NTP inhalation bioassay to be sufficient to characterize oncogenic hazards. (TR-306) 75-09-2
Proposed Rule Nitrobenzene EPA proposed rule to withdraw testing requirements under TSCA. Ongoing government and manufacturers' tests are expected to meet all testing.

June 19, 1984 -- 49 FR 25013
EPA concluded that NTP oncogenicity and subchronic effects testing would be sufficient and so didn't require further testing for these effects. 98-95-3
Proposed Rule Volatile Synthetic Organic Chemicals EPA proposed rule for National Primary Drinking Water Regulations establishing Recommended Maximum Contaminant Levels for several VOC's.

June 12, 1984 -- 49 FR 24330
NTP studies of trichlorethylene; 1,1,1-trichlorethane; 1,1-dichloroethylene; and p-dichlorobenzene. (TR-319) (TR-228) (TR-243) (TR-273) (TR-262) 106-46-7
79-01-6
71-55-6
75-35-4
Proposed Rule Fluoroalkenes EPA notice of proposed decision to adopt a negotiated testing program in lieu of required testing.

June 04, 1984 -- 49 FR 23112
NTP planning testing of tetrafluoroethane and vinylidene. (TR-228) 75-35-4
Notice Bis(2-Ethylhexyl) Terephthalate EPA notice of decision to adopt negotiated testing program.

June 04, 1984 -- 49 FR 23110
NTP has nominated two chemicals similar to the metabolites of DOTP for genotoxicity testing. 104-76-7
4376-20-9
Notice Toluene EPA notice of decision not to regulate under CAA based on studies showing toluene not to pose a significant risk to public health. This decision is not relevant to regulation of toluene as a VOC under the air quality standards for ozone.

May 25, 1984 -- 49 FR 22195
NTP is currently conducting a lifetime bioassay on toluene. (TR-371) 108-88-3
Other Formaldehyde EPA ANPR announcing decision that TSCA Section 4f priority consideration is applicable in 2 exposure categories, and initiating a regulatory investigation.

May 23, 1984 -- 49 FR 21870
Federal Panel on Formaldehyde, under the aegis of NTP, reviewed CIIT's bioassay methodology from CIIT inhalation study showing nasal cancer in rats. 50-00-0
Notice Calcium, Cobalt, and Lead Napthenates EPA notice of determination not to require testing.

May 21, 1984 -- 49 FR 21411
NTP planning testing of cobalt naphthenate and cobalt sulfate; NTP currently testing naphthenic acid; NTP has completed mutagenicity tests of lead naphthenate. 10124-43-3
61789-51-3
Other 1,3-Butadiene EPA ANPR and invitation to submit data on controlling exposures, following recent bioassays establishing carcinogenicity.

May 15, 1984 -- 49 FR 20524
NTP chronic oncology studies show carcinogenicity in both sexes of rats and mice; NTP planning further teratology testing. (TR-288) 106-99-0
Proposed Rule Cyromazine EPA proposed temporary feed additive regulation.

April 27, 1984 -- 49 FR 18130
NTP bioassay of Melamine, a metabolite of Cyromazine, showed significant increase in bladder carcinomas in male rats. (TR-245) 108-78-1
Notice Cyromazine EPA proposed rule to establish feed additive regulation setting temporary maximum permissible residue level in poultry feed.

April 27, 1984 -- 49 FR 18120
NTP bioassay of Melamine, a metabolite of Cyromazine, showed a significant increase in bladder carcinomas in male rats. (TR-245) 108-78-1
Notice Cyromazine EPA notice of proposed conditional registration under FIFRA for temporary period.

April 27, 1984 -- 49 FR 18172
As a result of the reported oncogenicity of Melamine in the NTP bioassay, the agency stopped the Cyromazine registration process...until it could review the NTP bioassay. (TR-245) 108-78-1
Notice Isophorone EPA notice of decision to adopt negotiated testing program.

January 17, 1984 -- 49 FR 2012
NTP's initiation of a long-term bioassay, together with CMA proposed testing, make it unnecessary to require TSCA Section 4 testing. (TR-291) 78-59-1
Proposed Rule 1,2-Dichloropropane EPA proposed test rule

January 06, 1984 -- 49 FR 899
NTP 2-year bioassay (TR-263) 78-87-5
Notice 1,2-Butylene Oxide EPA notice of determination not to require testing.

January 04, 1984 -- 49 FR 503
NTP inhalation bioassay of 1,2-butylene oxide. (TR-329) 106-88-7
Other Certain Alkyl Epoxides EPA ANPR on testing under TSCA

January 04, 1984 -- 49 FR 449
NTP subchronic study on 1,2-Epoxyhexadecane applied dermally. 7320-37-8
Proposed Rule Hydroquinone EPA Proposed test rule under TSCA Section 4.

January 04, 1984 -- 49 FR 438
EPA is not proposing oncogenicity testing of Hydroquinone since NTP is currently conducting a 2-year bioassay. (TR-366) 123-31-9
Notice Ethylene Oxide EPA notice of determination not to require testing.

January 03, 1984 -- 49 FR 200
NTP chronic inhalation bioassay. (TR-326) 75-21-8
Other Anilines EPA ANPR to require health and environmental effects testing.

January 03, 1984 -- 49 FR 108
NTP confirmatory study of effects of dietary exposure to 4-Chloroaniline Hydrochloride. (TR-351) 20265-96-7

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Occupational Safety and Health Administration (OSHA)

Notice Type Title Summary of Notice NTP Information Cited CASRN
Other Ethylene Oxide OSHA final standard on occupational PEL.

June 22, 1984 -- 49 FR 25734
NTP studies show significance of all malignancies rather than increases in only certain types of cancer, in calculating human risk. (TR-326) 75-21-8

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