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Regulatory Actions for Year 1984

Year Agency Title CASRN
1984 EPA
Certain Polyamino Chemical Substances

EPA proposed rule promulgating a significant new use rule under TSCA Section 5.

NTP Information Cited
NTP bioassay indicated that the dihydrochloride salt of Methylenedianiline is carcinogenic in both sexes of rats and mice. (TR-248)

  • Type: Proposed Rule
  • December 27, 1984
  • 49 FR 50209
13552-44-8
1984 EPA
[(Dinitrophenyl)Azo]-[2,4-Diamino-5-Methoxybenzene] Derivatives; Proposed Determination of Significant New Uses

EPA proposed rule promulgating a significant new use rule under TSCA Section 5.

NTP Information Cited
NTP and others have shown carcinogenic potential of close structural analogues of phenylenediamines.

  • Type: Proposed Rule
  • October 25, 1984
  • 49 FR 42960
1984 EPA
1,1,1-Trichloroethane

EPA final rule identifying specific chemical substance and mixture testing requirements.

NTP Information Cited
EPA did not propose chronic effects or oncogenicity testing because an NTP study is expected to provide sufficient information. (TR-262)

  • Type: Final Rule
  • October 10, 1984
  • 49 FR 39810
71-55-6
1984 OSHA
Ethylene Oxide

OSHA final standard on occupational PEL.

NTP Information Cited
NTP studies show significance of all malignancies rather than increases in only certain types of cancer, in calculating human risk. (TR-326)

  • Type: Other
  • June 22, 1984
  • 49 FR 25734
75-21-8
1984 EPA
Dichloromethane

EPA proposed rule to withdraw testing requirements under TSCA. Evaluation of data indicates dichloromethane does not present unreasonable risks.

NTP Information Cited
EPA expects NTP inhalation bioassay to be sufficient to characterize oncogenic hazards. (TR-306)

  • Type: Proposed Rule
  • June 19, 1984
  • 49 FR 25009
75-09-2
1984 EPA
Nitrobenzene

EPA proposed rule to withdraw testing requirements under TSCA. Ongoing government and manufacturers' tests are expected to meet all testing.

NTP Information Cited
EPA concluded that NTP oncogenicity and subchronic effects testing would be sufficient and so didn't require further testing for these effects.

  • Type: Proposed Rule
  • June 19, 1984
  • 49 FR 25013
98-95-3
1984 EPA
Volatile Synthetic Organic Chemicals

EPA proposed rule for National Primary Drinking Water Regulations establishing Recommended Maximum Contaminant Levels for several VOC's.

NTP Information Cited
NTP studies of trichlorethylene; 1,1,1-trichlorethane; 1,1-dichloroethylene; and p-dichlorobenzene. (TR-319) (TR-228) (TR-243) (TR-273) (TR-262)

  • Type: Proposed Rule
  • June 12, 1984
  • 49 FR 24330
106-46-7
79-01-6
71-55-6
75-35-4
1984 EPA
Fluoroalkenes

EPA notice of proposed decision to adopt a negotiated testing program in lieu of required testing.

NTP Information Cited
NTP planning testing of tetrafluoroethane and vinylidene. (TR-228)

  • Type: Proposed Rule
  • June 04, 1984
  • 49 FR 23112
75-35-4
1984 EPA
Bis(2-Ethylhexyl) Terephthalate

EPA notice of decision to adopt negotiated testing program.

NTP Information Cited
NTP has nominated two chemicals similar to the metabolites of DOTP for genotoxicity testing.

  • Type: Notice
  • June 04, 1984
  • 49 FR 23110
104-76-7
4376-20-9
1984 EPA
Toluene

EPA notice of decision not to regulate under CAA based on studies showing toluene not to pose a significant risk to public health. This decision is not relevant to regulation of toluene as a VOC under the air quality standards for ozone.

NTP Information Cited
NTP is currently conducting a lifetime bioassay on toluene. (TR-371)

  • Type: Notice
  • May 25, 1984
  • 49 FR 22195
108-88-3
1984 EPA
Formaldehyde

EPA ANPR announcing decision that TSCA Section 4f priority consideration is applicable in 2 exposure categories, and initiating a regulatory investigation.

NTP Information Cited
Federal Panel on Formaldehyde, under the aegis of NTP, reviewed CIIT's bioassay methodology from CIIT inhalation study showing nasal cancer in rats.

  • Type: Other
  • May 23, 1984
  • 49 FR 21870
50-00-0
1984 EPA
Calcium, Cobalt, and Lead Napthenates

EPA notice of determination not to require testing.

NTP Information Cited
NTP planning testing of cobalt naphthenate and cobalt sulfate; NTP currently testing naphthenic acid; NTP has completed mutagenicity tests of lead naphthenate.

  • Type: Notice
  • May 21, 1984
  • 49 FR 21411
10124-43-3
61789-51-3
1984 EPA
1,3-Butadiene

EPA ANPR and invitation to submit data on controlling exposures, following recent bioassays establishing carcinogenicity.

NTP Information Cited
NTP chronic oncology studies show carcinogenicity in both sexes of rats and mice; NTP planning further teratology testing. (TR-288)

  • Type: Other
  • May 15, 1984
  • 49 FR 20524
106-99-0
1984 EPA
Cyromazine

EPA proposed temporary feed additive regulation.

NTP Information Cited
NTP bioassay of Melamine, a metabolite of Cyromazine, showed significant increase in bladder carcinomas in male rats. (TR-245)

  • Type: Proposed Rule
  • April 27, 1984
  • 49 FR 18130
108-78-1
1984 EPA
Cyromazine

EPA proposed rule to establish feed additive regulation setting temporary maximum permissible residue level in poultry feed.

NTP Information Cited
NTP bioassay of Melamine, a metabolite of Cyromazine, showed a significant increase in bladder carcinomas in male rats. (TR-245)

  • Type: Notice
  • April 27, 1984
  • 49 FR 18120
108-78-1
1984 EPA
Cyromazine

EPA notice of proposed conditional registration under FIFRA for temporary period.

NTP Information Cited
As a result of the reported oncogenicity of Melamine in the NTP bioassay, the agency stopped the Cyromazine registration process...until it could review the NTP bioassay. (TR-245)

  • Type: Notice
  • April 27, 1984
  • 49 FR 18172
108-78-1
1984 EPA
Isophorone

EPA notice of decision to adopt negotiated testing program.

NTP Information Cited
NTP's initiation of a long-term bioassay, together with CMA proposed testing, make it unnecessary to require TSCA Section 4 testing. (TR-291)

  • Type: Notice
  • January 17, 1984
  • 49 FR 2012
78-59-1
1984 EPA
1,2-Dichloropropane

EPA proposed test rule

NTP Information Cited
NTP 2-year bioassay (TR-263)

  • Type: Proposed Rule
  • January 06, 1984
  • 49 FR 899
78-87-5
1984 EPA
1,2-Butylene Oxide

EPA notice of determination not to require testing.

NTP Information Cited
NTP inhalation bioassay of 1,2-butylene oxide. (TR-329)

  • Type: Notice
  • January 04, 1984
  • 49 FR 503
106-88-7
1984 EPA
Certain Alkyl Epoxides

EPA ANPR on testing under TSCA

NTP Information Cited
NTP subchronic study on 1,2-Epoxyhexadecane applied dermally.

  • Type: Other
  • January 04, 1984
  • 49 FR 449
7320-37-8
1984 EPA
Hydroquinone

EPA Proposed test rule under TSCA Section 4.

NTP Information Cited
EPA is not proposing oncogenicity testing of Hydroquinone since NTP is currently conducting a 2-year bioassay. (TR-366)

  • Type: Proposed Rule
  • January 04, 1984
  • 49 FR 438
123-31-9
1984 EPA
Ethylene Oxide

EPA notice of determination not to require testing.

NTP Information Cited
NTP chronic inhalation bioassay. (TR-326)

  • Type: Notice
  • January 03, 1984
  • 49 FR 200
75-21-8
1984 EPA
Anilines

EPA ANPR to require health and environmental effects testing.

NTP Information Cited
NTP confirmatory study of effects of dietary exposure to 4-Chloroaniline Hydrochloride. (TR-351)

  • Type: Other
  • January 03, 1984
  • 49 FR 108
20265-96-7