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Regulatory Actions for Year 1985

Year Agency Title CASRN
1985 EPA
Hydroquinone

EPA proposed rule on testing standards for hydroquinone.

NTP Information Cited
NTP 2-year gavage study will provide data for comparison with dermal contact data from required toxicokinetic studies. (TR-366)

  • Type: Proposed Rule
  • December 30, 1985
  • 50 FR 53160
123-31-9
1985 EPA
Perchloroethylene

EPA notice of assessment of perc as a potentially toxic air pollutant and intent to list under CAA Section 112.

NTP Information Cited
NTP inhalation study, which showed a carcinogenic potential in male rats and both sexes of mice, "has resulted in this notice of intent to list." (TR-311)

  • Type: Notice
  • December 26, 1985
  • 50 FR 52880
127-18-4
1985 EPA
Tri­chloro­ethyl­ene

EPA notice of assessment of TCE as a potentially toxic air pollutant and intent to list under CAA Section 112. (This rule was clarified on 3/5/86.)

NTP Information Cited
"The conclusion that TCE is a probable carcinogen is based on the findings of the NCI (1976) and NTP (1982) mouse studies..." (TR-243)

  • Type: Notice
  • December 23, 1985
  • 50 FR 52422
79-01-6
1985 EPA
Hydroquinone

EPA final rule requiring testing under TSCA Section 4.

NTP Information Cited
Carcinogenicity testing not required because NTP conducting 2-year bioassay. (TR-366)

  • Type: Final Rule
  • December 20, 1985
  • 50 FR 53145
123-31-9
1985 FDA
Methylene Chloride

FDA proposed rule to ban use in cosmetic products.

NTP Information Cited
NTP studies concluded that methylene chloride is a carcinogen in mice and can induce cancer at sites remote from the site of administration. (TR-306)

  • Type: Proposed Rule
  • December 18, 1985
  • 50 FR 51551
75-09-2
1985 OSHA
Benzene

OSHA proposed rule on occupational exposure to benzene to reduce PEL from 10 ppm to 8-hr TWA to 1 ppm to reduce risk of leukemia and other adverse health consequences.

NTP Information Cited
"NTP has demonstrated statistically significant, dose-dependent increase in tumors of multiple sites for both sexes of two species." (TR-289)

  • Type: Final Rule
  • December 10, 1985
  • 50 FR 50512
71-43-2
1985 EPA
Hazardous Waste Management System

EPA proposed rule to list used oil as hazardous waste.

NTP Information Cited
Reference to two NTP perchloroethylene inhalation studies of mice and rats which EPA is evaluating and expects to result in a B-2 classification of perc. (TR-311)

  • Type: Proposed Rule
  • November 29, 1985
  • 50 FR 49258
127-18-4
1985 EPA
Propylene Oxide

EPA final rule to require testing for developmental toxicity under TSCA Section 4.

NTP Information Cited
NTP 2-year studies on rats and mice demonstrated evidence of carcinogenicity. (TR-267)

  • Type: Final Rule
  • November 27, 1985
  • 50 FR 48762
75-56-9
1985 EPA
Synthetic Organic Chemicals, Inorganic Chemicals, and Microorganisms

EPA proposed rule to establish Recommended Maximum Contaminant Levels as part of the National Primary Drinking Water Regulation under the Safe Drinking Water Act.

NTP Information Cited
NTP studies of 1,2-dichloropropane; monochlorobenzene; dichlorobenzene; 1,2 dibromoethane; penta­chloro­phenol; toluene; xylene; 2,3,7,8-TCDD; and ingestion of asbestos. (TR-327) (TR-371) (TR-319) (TR-263) (TR-349) (TR-255) (TR-210) (TR-261)

  • Type: Proposed Rule
  • November 13, 1985
  • 50 FR 46936
1330-20-7
108-88-3
106-46-7
78-87-5
1746-01-6 87-86-5
95-50-1
106-93-4
108-90-7
12001-28-4
12001-29-5
12172-73-5
14567-73-8
1985 EPA
Volatile Synthetic Organic Chemicals

EPA notice of new evidence and requests for comment on new NTP report on tetrachloroethylene.

NTP Information Cited
EPA reopened comment period specifically to provide opportunity for comment on NTP report.

  • Type: Notice
  • November 13, 1985
  • 50 FR 47025
127-18-4
1985 EPA
Pentabromoethylbenzene

EPA proposed rule on testing under TSCA Section 4.

NTP Information Cited
NTP tests were performed using Salmonella typhimurium.

  • Type: Proposed Rule
  • November 13, 1985
  • 50 FR 46785
85-22-3
1985 EPA
Volatile Synthetic Organic Chemicals

EPA final rule promulgating National Primary Drinking Water regulations.

NTP Information Cited
NTP rat and mice inhalation bioassay of tetrachloroethylene demonstrated carcinogenicity in both species. NTP gavage bioassay of p-dichlorobenzene showed carcinogenicity in both sexes of mice and female rats showed no evidence of carcinogenicity. (TR-319) (TR-311)

  • Type: Final Rule
  • November 13, 1985
  • 50 FR 46880
106-46-7
127-18-4
1985 EPA
2-Mercaptobenzothiazole

EPA proposed rule requiring testing under TSCA Section 4.

NTP Information Cited
NTP carcinogenesis study in progress. (TR-332)

  • Type: Proposed Rule
  • November 06, 1985
  • 50 FR 46121
149-30-4
1985 EPA
Fluoroalkenes

EPA proposed rule requiring testing.

NTP Information Cited
NTP study of vinylidene fluoride.

  • Type: Proposed Rule
  • November 06, 1985
  • 50 FR 46133
75-38-7
1985 FDA
Cinnamyl Anthranilate

FDA final rule prohibiting use in human food.

NTP Information Cited
NTP panel on Chemical Carcinogenesis Testing and Evaluation recommended continued use of the B55526 C55523 and F55521 mouse.

  • Type: Final Rule
  • October 23, 1985
  • 50 FR 42929
87-29-6
1985 EPA
Methylene Chloride

EPA ANPR announcing initiation of comprehensive regulatory investigation.

NTP Information Cited
NTP inhalation bioassay demonstrated carcinogenicity in two species. (TR-306)

  • Type: Other
  • October 17, 1985
  • 50 FR 42037
75-09-2
1985 EPA
1,3-Butadiene

EPA notice of intent to list under CAA Section 112 as a potentially toxic air pollutant.

NTP Information Cited
Reference to NTP mouse study which was prematurely terminated due to excess deaths.

  • Type: Notice
  • October 10, 1985
  • 50 FR 41466
106-99-0
1985 EPA
1,3-Butadiene

EPA referral to OSHA under TSCA Section 9.

NTP Information Cited
Reference to NTP report on toxicological and carcinogenesis studies. (TR-288)

  • Type: Other
  • October 10, 1985
  • 50 FR 41393
106-99-0
1985 EPA
Dioxin-containing wastes

EPA tentative denial of petition to amend the rule listing certain dioxin-containing wastes as acute hazardous wastes.

NTP Information Cited
Reference to NCI/NTP bioassay of HXCDD. (TR-202)

  • Type: Other
  • October 08, 1985
  • 50 FR 41125
57653-85-7
1985 EPA
Hexachlorocyclopentadiene

EPA notice of intent not to regulate and solicitation of information.

NTP Information Cited
Ongoing NTP study. (TR-437)

  • Type: Notice
  • October 01, 1985
  • 50 FR 40154
77-47-4
1985 EPA
Chloroprene

EPA notice of intent not to regulate and solicitation of information.

NTP Information Cited
Ongoing NTP carcinogenicity and reproductive hazard study.

  • Type: Notice
  • September 27, 1985
  • 50 FR 39632
126-99-8
1985 EPA
Benzyl Butyl Phthalate

EPA proposed test rule.

NTP Information Cited
NTP planned reproduction effects and cancer studies make it unnecessary to require health effects testing at this time. (TR-458)

  • Type: Proposed Rule
  • September 06, 1985
  • 50 FR 36446
85-68-7
1985 FDA
Certain Color Additives

FDA final rule postponing closing dates for provisional listing of certain color additives to allow uninterrupted use while scientific evaluation continues.

NTP Information Cited
NTP found a clear relationship between D Red No. 9, which has indicated carcinogenic effects and D Red No. 33 that provides a basis for concern about the possible carcinogenicity of No. 33. (TR-225)

  • Type: Final Rule
  • September 04, 1985
  • 50 FR 35783
5160-02-1
1985 EPA
Chlorinated Benzenes

EPA notice of intent not to regulate chlorinated benzenes under CAA.

NTP Information Cited
NTP carcinogenesis testing of 1,4-dichlorobenzene is currently underway. (TR-319)

  • Type: Notice
  • August 13, 1985
  • 50 FR 32628
106-46-7
1985 EPA
Manganese

EPA decision not to regulate manganese under CAA.

NTP Information Cited
Regulation not needed at this time because NTP has scheduled carcinogenicity testing and is conducting mutagenicity studies. (TR-428)

  • Type: Other
  • August 13, 1985
  • 50 FR 32627
10034-96-5
1985 FDA
Irradiation of Food

FDA final rule to permit gamma radiation of pork to control Trichinella Spiralis, citing NTP study which concluded that histopathological data did not show a carcinogenic response.

NTP Information Cited
NTP review, conducted at FDA's request, concluded that data did not demonstrate a carcinogenic response.

  • Type: Final Rule
  • July 22, 1985
  • 50 FR 29658
1985 EPA
4,4-Methylenedianiline

EPA notice of decision to refer to OSHA under TSCA Section 9.

NTP Information Cited
NTP study demonstrated that dihydrochloride salt of 4,4-MDA is carcinogenic in both sexes of rats and mice. (TR-248)

  • Type: Proposed Rule
  • July 05, 1985
  • 50 FR 27674
13552-44-8
1985 FDA
Certain Color Additives

FDA proposed rule to postpone closing dates on provisional listing of certain color additives.

NTP Information Cited
NTP examined data on D Red Nos. 9 and 33 and concluded that there is a relationship between them that provides a basis for concern about the possible carcinogenicity of No. 33. (TR-225)

  • Type: Proposed Rule
  • June 26, 1985
  • 50 FR 26377
5160-02-1
1985 FDA
Irradiation of Food

FDA final rule to permit irradiation of dry or dehydrated enzyme preparations.

NTP Information Cited
NTP review, conducted at FDA's request, concluded that data did not demonstrate a carcinogenic response.

  • Type: Final Rule
  • June 10, 1985
  • 50 FR 24190
1985 EPA
Methyl Chloroform

EPA notice of assessment as a potentially toxic air pollutant and determination that regulation under CAA is not warranted.

NTP Information Cited
EPA awaiting results of NTP carcinogenicity bioassay. (TR-262)

  • Type: Notice
  • June 10, 1985
  • 50 FR 24314
71-55-6
1985 EPA
Diethylenetriamine

EPA final rule on testing requirements under TSCA Section 4.

NTP Information Cited
NTP conducted Ames Salmonella/Microsome Plate Test with negative results.

  • Type: Final Rule
  • May 23, 1985
  • 50 FR 21398
111-40-0
1985 EPA
2-Ethylhexanoic Acid

EPA proposed rule on testing under TSCA Section 4.

NTP Information Cited
NTP tests of four chemicals containing 2-ethylhexyl showed them to be animal oncogenes; NTP plans test of 2-ethylhexanol.

  • Type: Final Rule
  • May 17, 1985
  • 50 FR 20679
104-76-7
1985 EPA
Bisphenol A

EPA proposed rule on testing under TSCA Section 4.

NTP Information Cited
"EPA finds that sufficient data are available from the NTP bioassay report to reasonably predict that ingested BPA is not oncogenic...EPA believes appropriate developmental toxicity testing has been conducted at NTP." (TR-215)

  • Type: Proposed Rule
  • May 17, 1985
  • 50 FR 20691
80-05-7
1985 EPA
Cyromazine

EPA notice of determination to issue conditional registration under FIFRA.

NTP Information Cited
NTP bioassay demonstrated that high dose ingestion induced cancer. NTP study of Melamine, a metabolite of Cyromazine. (TR-245)

  • Type: Notice
  • May 15, 1985
  • 50 FR 20373
108-78-1
1985 EPA
Methylene Chloride

EPA notice of initiation of accelerated review under TSCA Section 4.

NTP Information Cited
NTP inhalation studies demonstrated carcinogenicity. (TR-306)

  • Type: Notice
  • May 14, 1985
  • 50 FR 20126
75-09-2
1985 FDA
Irradiation of Food

FDA final rule to permit irradiation of additional herbs, spices, and vegetable seasonings.

NTP Information Cited
FDA has referred USDA study to NTP for peer review.

  • Type: Final Rule
  • April 18, 1985
  • 50 FR 15415
N/A
1985 EPA
Dioxin-containing Wastes

EPA final rule listing certain dioxin-containing wastes as acute hazardous wastes.

NTP Information Cited
Re-evaluation by NTP of NCI study of HXCDD. (TR-202)

  • Type: Final Rule
  • January 14, 1985
  • 50 FR 1978
57653-85-7