National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/719249

Regulatory Actions for Year 1985




Environmental Protection Agency (EPA)

Notice Type Title Summary of Notice NTP Information Cited CASRN
Proposed Rule Hydroquinone EPA proposed rule on testing standards for hydroquinone.

December 30, 1985 -- 50 FR 53160
NTP 2-year gavage study will provide data for comparison with dermal contact data from required toxicokinetic studies. (TR-366) 123-31-9
Notice Perchloroethylene EPA notice of assessment of perc as a potentially toxic air pollutant and intent to list under CAA Section 112.

December 26, 1985 -- 50 FR 52880
NTP inhalation study, which showed a carcinogenic potential in male rats and both sexes of mice, "has resulted in this notice of intent to list." (TR-311) 127-18-4
Notice Trichloroethylene EPA notice of assessment of TCE as a potentially toxic air pollutant and intent to list under CAA Section 112. (This rule was clarified on 3/5/86.)

December 23, 1985 -- 50 FR 52422
"The conclusion that TCE is a probable carcinogen is based on the findings of the NCI (1976) and NTP (1982) mouse studies..." (TR-243) 79-01-6
Final Rule Hydroquinone EPA final rule requiring testing under TSCA Section 4.

December 20, 1985 -- 50 FR 53145
Carcinogenicity testing not required because NTP conducting 2-year bioassay. (TR-366) 123-31-9
Proposed Rule Hazardous Waste Management System EPA proposed rule to list used oil as hazardous waste.

November 29, 1985 -- 50 FR 49258
Reference to two NTP perchloroethylene inhalation studies of mice and rats which EPA is evaluating and expects to result in a B-2 classification of perc. (TR-311) 127-18-4
Final Rule Propylene Oxide EPA final rule to require testing for developmental toxicity under TSCA Section 4.

November 27, 1985 -- 50 FR 48762
NTP 2-year studies on rats and mice demonstrated evidence of carcinogenicity. (TR-267) 75-56-9
Proposed Rule Synthetic Organic Chemicals, Inorganic Chemicals, and Microorganisms EPA proposed rule to establish Recommended Maximum Contaminant Levels as part of the National Primary Drinking Water Regulation under the Safe Drinking Water Act.

November 13, 1985 -- 50 FR 46936
NTP studies of 1,2-dichloropropane; monochlorobenzene; dichlorobenzene; 1,2 dibromoethane; pentachlorophenol; toluene; xylene; 2,3,7,8-TCDD; and ingestion of asbestos. (TR-327) (TR-371) (TR-319) (TR-263) (TR-349) (TR-255) (TR-210) (TR-261) 1330-20-7
108-88-3
106-46-7
78-87-5
1746-01-6
87-86-5
95-50-1
106-93-4
108-90-7
12001-28-4
12001-29-5
12172-73-5
14567-73-8
Notice Volatile Synthetic Organic Chemicals EPA notice of new evidence and requests for comment on new NTP report on tetrachloroethylene.

November 13, 1985 -- 50 FR 47025
EPA reopened comment period specifically to provide opportunity for comment on NTP report. 127-18-4
Proposed Rule Pentabromoethylbenzene EPA proposed rule on testing under TSCA Section 4.

November 13, 1985 -- 50 FR 46785
NTP tests were performed using Salmonella typhimurium. 85-22-3
Final Rule Volatile Synthetic Organic Chemicals EPA final rule promulgating National Primary Drinking Water regulations.

November 13, 1985 -- 50 FR 46880
NTP rat and mice inhalation bioassay of tetrachloroethylene demonstrated carcinogenicity in both species. NTP gavage bioassay of p-dichlorobenzene showed carcinogenicity in both sexes of mice and female rats showed no evidence of carcinogenicity. (TR-319) (TR-311) 106-46-7
127-18-4
Proposed Rule 2-Mercaptobenzothiazole EPA proposed rule requiring testing under TSCA Section 4.

November 06, 1985 -- 50 FR 46121
NTP carcinogenesis study in progress. (TR-332) 149-30-4
Proposed Rule Fluoroalkenes EPA proposed rule requiring testing.

November 06, 1985 -- 50 FR 46133
NTP study of vinylidene fluoride. 75-38-7
Other Methylene Chloride EPA ANPR announcing initiation of comprehensive regulatory investigation.

October 17, 1985 -- 50 FR 42037
NTP inhalation bioassay demonstrated carcinogenicity in two species. (TR-306) 75-09-2
Notice 1,3-Butadiene EPA notice of intent to list under CAA Section 112 as a potentially toxic air pollutant.

October 10, 1985 -- 50 FR 41466
Reference to NTP mouse study which was prematurely terminated due to excess deaths. 106-99-0
Other 1,3-Butadiene EPA referral to OSHA under TSCA Section 9.

October 10, 1985 -- 50 FR 41393
Reference to NTP report on toxicological and carcinogenesis studies. (TR-288) 106-99-0
Other Dioxin-containing wastes EPA tentative denial of petition to amend the rule listing certain dioxin-containing wastes as acute hazardous wastes.

October 08, 1985 -- 50 FR 41125
Reference to NCI/NTP bioassay of HXCDD. (TR-202) 57653-85-7
Notice Hexachlorocyclopentadiene EPA notice of intent not to regulate and solicitation of information.

October 01, 1985 -- 50 FR 40154
Ongoing NTP study. (TR-437) 77-47-4
Notice Chloroprene EPA notice of intent not to regulate and solicitation of information.

September 27, 1985 -- 50 FR 39632
Ongoing NTP carcinogenicity and reproductive hazard study. 126-99-8
Proposed Rule Benzyl Butyl Phthalate EPA proposed test rule.

September 06, 1985 -- 50 FR 36446
NTP planned reproduction effects and cancer studies make it unnecessary to require health effects testing at this time. (TR-458) 85-68-7
Notice Chlorinated Benzenes EPA notice of intent not to regulate chlorinated benzenes under CAA.

August 13, 1985 -- 50 FR 32628
NTP carcinogenesis testing of 1,4-dichlorobenzene is currently underway. (TR-319) 106-46-7
Other Manganese EPA decision not to regulate manganese under CAA.

August 13, 1985 -- 50 FR 32627
Regulation not needed at this time because NTP has scheduled carcinogenicity testing and is conducting mutagenicity studies. (TR-428) 10034-96-5
Proposed Rule 4,4-Methylenedianiline EPA notice of decision to refer to OSHA under TSCA Section 9.

July 05, 1985 -- 50 FR 27674
NTP study demonstrated that dihydrochloride salt of 4,4-MDA is carcinogenic in both sexes of rats and mice. (TR-248) 13552-44-8
Notice Methyl Chloroform EPA notice of assessment as a potentially toxic air pollutant and determination that regulation under CAA is not warranted.

June 10, 1985 -- 50 FR 24314
EPA awaiting results of NTP carcinogenicity bioassay. (TR-262) 71-55-6
Final Rule Diethylenetriamine EPA final rule on testing requirements under TSCA Section 4.

May 23, 1985 -- 50 FR 21398
NTP conducted Ames Salmonella/Microsome Plate Test with negative results. 111-40-0
Final Rule 2-Ethylhexanoic Acid EPA proposed rule on testing under TSCA Section 4.

May 17, 1985 -- 50 FR 20679
NTP tests of four chemicals containing 2-ethylhexyl showed them to be animal oncogenes; NTP plans test of 2-ethylhexanol. 104-76-7
Proposed Rule Bisphenol A EPA proposed rule on testing under TSCA Section 4.

May 17, 1985 -- 50 FR 20691
"EPA finds that sufficient data are available from the NTP bioassay report to reasonably predict that ingested BPA is not oncogenic...EPA believes appropriate developmental toxicity testing has been conducted at NTP." (TR-215) 80-05-7
Notice Cyromazine EPA notice of determination to issue conditional registration under FIFRA.

May 15, 1985 -- 50 FR 20373
NTP bioassay demonstrated that high dose ingestion induced cancer. NTP study of Melamine, a metabolite of Cyromazine. (TR-245) 108-78-1
Notice Methylene Chloride EPA notice of initiation of accelerated review under TSCA Section 4.

May 14, 1985 -- 50 FR 20126
NTP inhalation studies demonstrated carcinogenicity. (TR-306) 75-09-2
Final Rule Dioxin-containing Wastes EPA final rule listing certain dioxin-containing wastes as acute hazardous wastes.

January 14, 1985 -- 50 FR 1978
Re-evaluation by NTP of NCI study of HXCDD. (TR-202) 57653-85-7

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Food and Drug Administration (FDA)

Notice Type Title Summary of Notice NTP Information Cited CASRN
Proposed Rule Methylene Chloride FDA proposed rule to ban use in cosmetic products.

December 18, 1985 -- 50 FR 51551
NTP studies concluded that methylene chloride is a carcinogen in mice and can induce cancer at sites remote from the site of administration. (TR-306) 75-09-2
Final Rule Cinnamyl Anthranilate FDA final rule prohibiting use in human food.

October 23, 1985 -- 50 FR 42929
NTP panel on Chemical Carcinogenesis Testing and Evaluation recommended continued use of the B55526 C55523 and F55521 mouse. 87-29-6
Final Rule Certain Color Additives FDA final rule postponing closing dates for provisional listing of certain color additives to allow uninterrupted use while scientific evaluation continues.

September 04, 1985 -- 50 FR 35783
NTP found a clear relationship between D Red No. 9, which has indicated carcinogenic effects and D Red No. 33 that provides a basis for concern about the possible carcinogenicity of No. 33. (TR-225) 5160-02-1
Final Rule Irradiation of Food FDA final rule to permit gamma radiation of pork to control Trichinella Spiralis, citing NTP study which concluded that histopathological data did not show a carcinogenic response.

July 22, 1985 -- 50 FR 29658
NTP review, conducted at FDA's request, concluded that data did not demonstrate a carcinogenic response.
Proposed Rule Certain Color Additives FDA proposed rule to postpone closing dates on provisional listing of certain color additives.

June 26, 1985 -- 50 FR 26377
NTP examined data on D Red Nos. 9 and 33 and concluded that there is a relationship between them that provides a basis for concern about the possible carcinogenicity of No. 33. (TR-225) 5160-02-1
Final Rule Irradiation of Food FDA final rule to permit irradiation of dry or dehydrated enzyme preparations.

June 10, 1985 -- 50 FR 24190
NTP review, conducted at FDA's request, concluded that data did not demonstrate a carcinogenic response.
Final Rule Irradiation of Food FDA final rule to permit irradiation of additional herbs, spices, and vegetable seasonings.

April 18, 1985 -- 50 FR 15415
FDA has referred USDA study to NTP for peer review. N/A

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Occupational Safety and Health Administration (OSHA)

Notice Type Title Summary of Notice NTP Information Cited CASRN
Final Rule Benzene OSHA proposed rule on occupational exposure to benzene to reduce PEL from 10 ppm to 8-hr TWA to 1 ppm to reduce risk of leukemia and other adverse health consequences.

December 10, 1985 -- 50 FR 50512
"NTP has demonstrated statistically significant, dose-dependent increase in tumors of multiple sites for both sexes of two species." (TR-289) 71-43-2

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