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Regulatory Actions for Year 1988

Year Agency Title CASRN
1988 EPA
Hazardous Waste Management System

EPA proposed rule to amend RCRA regulations to list as hazardous 4 additional wastes from wood preserving and surface protection processes.

NTP Information Cited
Reference to NTP study demonstrating carcinogenicity of penta­chloro­phenol. (TR-349)

  • Type: Proposed Rule
  • December 30, 1988
  • 53 FR 53282
87-86-5
1988 FDA
Dimethyl Dicarbonate

FDA final rule amending food additive regulations to allow use as yeast inhibitor in wines.

NTP Information Cited
NTP carcinogenesis bioassay of methyl carbamate which is produced in food by dimethyl dicarbonate. (TR-328)

  • Type: Final Rule
  • October 21, 1988
  • 53 FR 41325
598-55-0
1988 EPA
Methyl Ethyl Ketoxime

EPA proposed rule to require testing under TSCA Section 4.

NTP Information Cited
Reference to NTP study of methyl ethyl ketone.

  • Type: Proposed Rule
  • September 15, 1988
  • 53 FR 35838
78-93-3
1988 EPA
2-Mercaptobenzothiazole

EPA final rule to require testing under TSCA Section 4.

NTP Information Cited
NTP chronic and subchronic studies of MBT. (TR-332)

  • Type: Final Rule
  • September 07, 1988
  • 54 FR 34514
149-30-4
1988 EPA
Certain Chemicals in Anilines Category

EPA notice of termination of rulemaking because there is no basis for finding of unreasonable risk of injury to health or the environment.

NTP Information Cited
Reference to study of 4-chloro-2-nitroaniline supported by NIEHS.

  • Type: Notice
  • August 19, 1988
  • 53 FR 31814
89-63-4
1988 EPA
Aniline & 7 Substituted Anilines

EPA final rule regarding enforceable testing consent orders under TSCA.

NTP Information Cited
References to studies of p-chloroaniline and 4-nitroaniline supported by NIEHS.

  • Type: Final Rule
  • August 19, 1988
  • 53 FR 31804
106-47-8
100-01-6
20265-96-7
1988 FDA
D& C Red No. 36

FDA final rule permanently listing D Red No. 36 for general use except in eye area.

NTP Information Cited
At FDA's request, NTP compared data on D Red No. 33 with D Red No. 9, a splenic carcinogen. (Nos. 33 and 36 were being considered jointly). (TR-225)

  • Type: Final Rule
  • August 02, 1988
  • 53 FR 29024
5160-02-1
1988 EPA
Benzene

EPA proposed rule on setting NESHAP applicable to benzene equipment leaks, ethylbenzene/styrene and maleic anhydride process vents, benzene storage vessels, and coke byproduct recovery plants.

NTP Information Cited
NTP 2-year chronic study of mice and rats orally exposed found significant incidence of cancers at multiple sites in both sexes and both species. (TR-289)

  • Type: Proposed Rule
  • July 28, 1988
  • 53 FR 28496
71-43-2
1988 FDA
D& C Red No. 8 and D& C Red No. 9

FDA notice of denial of petition for listing for use in ingested lip products and in externally applied drugs and cosmetics.

NTP Information Cited
NCI/NTP chronic rat study concluded that D Red No. 9 is carcinogenic for male F-344 rats. (TR-225)

  • Type: Notice
  • July 15, 1988
  • 53 FR 26886
5160-02-1
1988 EPA
Melamine

EPA proposed rule to delete melamine from list of toxic chemicals for which toxic chemical release reporting is required under SARA Section 313.

NTP Information Cited
NTP bioassay resulted in statistically significant increase in carcinomas in male rats. (TR-245)

  • Type: Proposed Rule
  • June 20, 1988
  • 53 FR 23128
108-78-1
1988 EPA
RCRA Hazardous Waste Identification

EPA notice regarding strategy for setting compound-specific dilution/attenuation factors in the Toxicity Characteristic used by waste generators to determine whether their solid wastes are hazardous.

NTP Information Cited
NTP studies of 1,4-dichlorobenzene, Pyridine, and Methylene Chloride (TR-306) (TR-319) (TR-283)

  • Type: Notice
  • May 19, 1988
  • 53 FR 18024
75-09-2
106-46-7
110-86-1
1988 EPA
Naphthalene

EPA notice of assessment results under Clean Air Act, concluding that the health data base is insufficient to warrant regulation under the CAA.

NTP Information Cited
NTP 2-year inhalation study is currently in progress. (TR-410)

  • Type: Notice
  • March 21, 1988
  • 53 FR 9138
91-20-3
1988 EPA
Isopropanol

EPA proposed rule to require testing under TSCA Section 4.

NTP Information Cited
"The only adequate study" of mutagenicity is a salmonella reverse mutation assay conducted by NTP.

  • Type: Proposed Rule
  • March 16, 1988
  • 53 FR 8638
67-63-0
1988 EPA
Diethylene Glycol Butyl Ether and Diethylene Glycol Butyl Ether Acetate

EPA final rule to require testing under TSCA Section 4.

NTP Information Cited
NTP currently is conducting an oncogenicity study of structurally similar glycol ethers.

  • Type: Final Rule
  • February 26, 1988
  • 53 FR 5932
112-34-5
1988 EPA
Dichlorvos

EPA notice of initiation of special review of determine whether registration should be cancelled or otherwise amended in light of carcinogenic and other health effects.

NTP Information Cited
"Based on the NTP oncogenicity studies and chronic toxicity studies, in conjunction with exposure assessments of dietary, worker, residential, and pet risks, EPA has determined that all uses of dichlorvos have met the criterion for initiation of Special Review." (TR-342)

  • Type: Notice
  • February 24, 1988
  • 53 FR 5542
62-73-7
1988 EPA
Commercial Hexane

EPA final rule to require testing under TSCA Section 4.

NTP Information Cited
Description of NTP dosing regimen in discussion of subchronic test standards.

  • Type: Final Rule
  • February 05, 1988
  • 53 FR 3382
110-54-3