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Regulatory Actions for Year 1989

Year Agency Title CASRN
1989 EPA
Ethylene Bisdthiocarbamate (EBDC) Pesticides

EPA Notice of Preliminary Determination to propose cancellation of certain registrations of EBDC products and propose modifications of registrations not cancelled.

NTP Information Cited
NTP carcinogenicity studies of ethylene thiourea (ETU) (CAS: 96-45-7), a common contaminant, metabolite, and degradation product of EBDCs. (TR-388)

  • Type: Notice
  • December 20, 1989
  • 54 FR 52158
96-45-7
1989 EPA
Inert Ingredients in Pesticides

EPA notice for revision of lists of inert ingredients of toxicological concern.

NTP Information Cited
Based on an NTP bioassay di-(2-ethylhexyl)adipate was moved to List 1 ("Inerts of Toxicological Concern") from List 3 ("Inerts of Unknown Toxicity") (TR-212)

  • Type: Notice
  • November 22, 1989
  • 54 FR 48314
103-23-1
1989 FDA
4,4'-Diphenylmethanediamine

FDA final rule amending food additive regulations to allow use of polyamide-imide resins in articles which come into contact with food.

NTP Information Cited
Data from NTP carcinogenesis bioassay used to estimate upper-bound level of lifetime risk from proposed use of 4,4'-diiphenylmethanediamine.

  • Type: Final Rule
  • October 23, 1989
  • 54 FR 43168
1989 EPA
Methyl Ethyl Ketoxime (96-29-7)

EPA final rule under TSCA 4 to require testing for oncogenicity, mutagenicity, developmental toxicity, reproductive toxicity, neurotoxicity, and pharmacokinetics.

NTP Information Cited
Reference to NTP research on MEKA and other NTP studies relevant to the testing requirements.

  • Type: Final Rule
  • September 13, 1989
  • 54 FR 37799
96-29-7
1989 MSHA
Lead

MSHA proposed rule to revise standards for air quality and chemical substances in mines.

NTP Information Cited
NTP recommendation that lead oxide and lead sulfide be ranked a high priority for acute toxicity studies cited in support of proposed lead exposure standard.

  • Type: Proposed Rule
  • August 29, 1989
  • 54 FR 35760
1317-36-8
1314-87-0
1989 EPA
Reportable Quantities: 1,4-dioxane, 2-ethoxyethanol, ethylene oxide, 2-nitropropane, perchloroethylene, and saccharin.

EPA final rule adjusting the reportable quantities (RQ) of these six substances; hazardous substance releases in quantities equal to or greater than their RQ's must be reported to the National Response Center.

NTP Information Cited
"The NTP annual reports (on carcinogens) and IARC monographs are used only as an initial screen for substances to be evaluated for potential carcinogenicity by the Agency. EPA follows the procedures set out in its Guidelines for Carcinogen Risk Assessment to make this determination."

  • Type: Final Rule
  • August 14, 1989
  • 54 FR 33418
75-21-8
110-80-5
79-46-9
123-91-1
81-07-2
1989 EPA
Asbestos

EPA final rule under TSCA 6 to prohibit future manufacture, importation, processing, and distribution in commerce of asbestos in almost all products.

NTP Information Cited
Reference to NTP toxicology and carcinogenesis studies of chrysotile asbestos. (TR-246) (TR-295)

  • Type: Final Rule
  • July 12, 1989
  • 54 FR 29460
12001-29-5
1989 EPA
Reportable quantities: Methyl Isocyanate (624-83-9), Aluminum Thiosulfate, and 258 other substances

EPA final rule retaining statutory RQ for MIC, delisting ammonium thiosulfate, and adjusting the RQ's of 258 hazardous substances.

NTP Information Cited
Use of NTP report on carcinogens used as an initial screen for substances to be evaluated for potential carcinogenicity. MIC studies documented in EHP volume 72 utilized in decision to retain MIC.

  • Type: Final Rule
  • July 12, 1989
  • 54 FR 33426
624-83-9
1989 FDA
Methylene Chloride (75-09-2)

FDA final rule banning use of methylene chloride as an ingredient of cosmetic products.

NTP Information Cited
NTP concluded with respect to their inhalation study on methylene chloride that there was clear evidence of carcinogenicity in mice and female rats and some evidence of carcinogenicity in male rats.

  • Type: Final Rule
  • June 29, 1989
  • 54 FR 27328
75-09-2
1989 EPA
Drinking Water

EPA proposed rule on maximum contaminant level goals and National Primary Drinking Water Regulations for 30 synthetic organic chemicals and 8 inorganic chemicals.

NTP Information Cited
NTP bioassays of chrysotile asbestos, 1,2-dichloropropane, monochlorobenzene, pentachlorophenol,styrene, tetrachloroethylene, and xylenes are cited. (TR-327) (TR-263) (TR-185) (TR-311) (TR-349) (TR-261) (TR-295)

  • Type: Proposed Rule
  • June 23, 1989
  • 54 FR 22062
78-87-5
100-42-5
87-86-5
108-90-7
12001-29-5 127-18-4
1330-20-7
1989 EPA
Copper Phthalocyanine Pigments

EPA proposed rule to exempt Pigments Blue 15, Green 7, and Green 36 from SARA 313 release reporting requirements.

NTP Information Cited
NTP oral studies of PB-15 and PG-7 showed no signs of compound-related toxicity.

  • Type: Proposed Rule
  • May 15, 1989
  • 54 FR 20866
147-14-8
1328-53-6
1989 OSHA
4,4'-Methylenedianiline (13552-44-8)

OSHA proposed rule to establish an 8-hour time-weighted average (TWA) of 10ppb, a short-term exposure limit (STEL) of 100PPB, and associated provisions.

NTP Information Cited
The OSHA-established MDA Advisory Committee used the NTP study "as the principal basis for its carcinogenicity findings." (TR-248)

  • Type: Proposed Rule
  • May 12, 1989
  • 54 FR 20672
13552-44-8
1989 OSHA
Methylene Chloride (75-09-2)

OSHA agenda notice to planned NPRM setting new standard for occupational exposure.

NTP Information Cited
This regulatory action is in response to a petition based on information from NTP and EPA.

  • Type: Notice
  • April 24, 1989
  • 54 FR 16873
75-09-2
1989 EPA
Dinitrobenzenes, Allyl Alcohol, Diethylamine, 2,3-Dichloropropene, Isosafrole, Creosote, Dinitrotoluene, Toluenediisocyanate

EPA proposed rule to add these chemicals to list of chemicals for which release reporting is required under SARA Section 313.

NTP Information Cited
NTP Annual Report on Carcinogens is one of the 4 data sources used by EPA in making carcinogenic evaluations of Section 313 determinations.

  • Type: Proposed Rule
  • April 21, 1989
  • 54 FR 16138
121-14-2
26471-62-5
109-89-7
8021-39-4
1989 EPA
Glycol Ethers

EPA final rule on enforceable testing consent order.

NTP Information Cited
References to NTP studies of ethylene glycol monomethyl ether, 2-ethoxyethanol, and ethylene glycol monobutyl ether.

  • Type: Final Rule
  • April 04, 1989
  • 54 FR 13470
109-86-4
110-80-5
111-76-2
1989 EPA
Captan

EPA notice of intent to cancel registrations.

NTP Information Cited
Rationale for combining organ sites and tumor sites in categorizing captan as a probable human carcinogen was based on NTP list of acceptable organ combinations. (TR-015)

  • Type: Notice
  • February 24, 1989
  • 54 FR 8116
133-06-2
1989 OSHA
Air Contaminants

OSHA final rule amending the air contaminants standard, including new table of Permissible Exposure Limits (PEL).

NTP Information Cited
NTP research cited includes bioassay of perchloroethylene and propylene oxide. (TR-311) (TR-267)

  • Type: Final Rule
  • January 19, 1989
  • 54 FR 2332
127-18-4
75-56-9