National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/719279

Regulatory Actions for Years 1980 to 1989




Consumer Product Safety Commission (CPSC)

Notice Type Title Summary of Notice NTP Information Cited CASRN
Final Rule Urea Formaldehyde Foam Insulation CPSC final rule banning UF foam insulation in residences and schools.

April 02, 1982 -- 47 FR 14366
Statement by the Director of NIEHS that Formaldehyde is an animal carcinogen is cited in support of the ban. 50-00-0
Proposed Rule Urea Formaldehyde Foam Insulation CPSC proposed rule to ban manufacture or sale in the US.

February 05, 1981 -- 46 FR 11188
NIEHS participation on Task Force to verify findings concerning carcinogenicity of urea formaldehyde. 50-00-0

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Environmental Protection Agency (EPA)

Notice Type Title Summary of Notice NTP Information Cited CASRN
Notice Ethylene Bisdthiocarbamate (EBDC) Pesticides EPA Notice of Preliminary Determination to propose cancellation of certain registrations of EBDC products and propose modifications of registrations not cancelled.

December 20, 1989 -- 54 FR 52158
NTP carcinogenicity studies of ethylene thiourea (ETU) (CAS: 96-45-7), a common contaminant, metabolite, and degradation product of EBDCs. (TR-388) 96-45-7
Notice Inert Ingredients in Pesticides EPA notice for revision of lists of inert ingredients of toxicological concern.

November 22, 1989 -- 54 FR 48314
Based on an NTP bioassay di-(2-ethylhexyl)adipate was moved to List 1 ("Inerts of Toxicological Concern") from List 3 ("Inerts of Unknown Toxicity") (TR-212) 103-23-1
Final Rule Methyl Ethyl Ketoxime (96-29-7) EPA final rule under TSCA 4 to require testing for oncogenicity, mutagenicity, developmental toxicity, reproductive toxicity, neurotoxicity, and pharmacokinetics.

September 13, 1989 -- 54 FR 37799
Reference to NTP research on MEKA and other NTP studies relevant to the testing requirements. 96-29-7
Final Rule Reportable Quantities: 1,4-dioxane, 2-ethoxyethanol, ethylene oxide, 2-nitropropane, perchloroethylene, and saccharin. EPA final rule adjusting the reportable quantities (RQ) of these six substances; hazardous substance releases in quantities equal to or greater than their RQ's must be reported to the National Response Center.

August 14, 1989 -- 54 FR 33418
"The NTP annual reports (on carcinogens) and IARC monographs are used only as an initial screen for substances to be evaluated for potential carcinogenicity by the Agency. EPA follows the procedures set out in its Guidelines for Carcinogen Risk Assessment to make this determination." 75-21-8
110-80-5
79-46-9
123-91-1
81-07-2
Final Rule Asbestos EPA final rule under TSCA 6 to prohibit future manufacture, importation, processing, and distribution in commerce of asbestos in almost all products.

July 12, 1989 -- 54 FR 29460
Reference to NTP toxicology and carcinogenesis studies of chrysotile asbestos. (TR-246) (TR-295) 12001-29-5
Final Rule Reportable quantities: Methyl Isocyanate (624-83-9), Aluminum Thiosulfate, and 258 other substances EPA final rule retaining statutory RQ for MIC, delisting ammonium thiosulfate, and adjusting the RQ's of 258 hazardous substances.

July 12, 1989 -- 54 FR 33426
Use of NTP report on carcinogens used as an initial screen for substances to be evaluated for potential carcinogenicity. MIC studies documented in EHP volume 72 utilized in decision to retain MIC. 624-83-9
Proposed Rule Drinking Water EPA proposed rule on maximum contaminant level goals and National Primary Drinking Water Regulations for 30 synthetic organic chemicals and 8 inorganic chemicals.

June 23, 1989 -- 54 FR 22062
NTP bioassays of chrysotile asbestos, 1,2-dichloropropane, monochlorobenzene, pentachlorophenol,styrene, tetrachloroethylene, and xylenes are cited. (TR-327) (TR-263) (TR-185) (TR-311) (TR-349) (TR-261) (TR-295) 78-87-5
100-42-5
87-86-5
108-90-7
12001-29-5
127-18-4
1330-20-7
Proposed Rule Copper Phthalocyanine Pigments EPA proposed rule to exempt Pigments Blue 15, Green 7, and Green 36 from SARA 313 release reporting requirements.

May 15, 1989 -- 54 FR 20866
NTP oral studies of PB-15 and PG-7 showed no signs of compound-related toxicity. 147-14-8
1328-53-6
Proposed Rule Dinitrobenzenes, Allyl Alcohol, Diethylamine, 2,3-Dichloropropene, Isosafrole, Creosote, Dinitrotoluene, Toluenediisocyanate EPA proposed rule to add these chemicals to list of chemicals for which release reporting is required under SARA Section 313.

April 21, 1989 -- 54 FR 16138
NTP Annual Report on Carcinogens is one of the 4 data sources used by EPA in making carcinogenic evaluations of Section 313 determinations. 121-14-2
26471-62-5
109-89-7
8021-39-4
Final Rule Glycol Ethers EPA final rule on enforceable testing consent order.

April 04, 1989 -- 54 FR 13470
References to NTP studies of ethylene glycol monomethyl ether, 2-ethoxyethanol, and ethylene glycol monobutyl ether. 109-86-4
110-80-5
111-76-2
Notice Captan EPA notice of intent to cancel registrations.

February 24, 1989 -- 54 FR 8116
Rationale for combining organ sites and tumor sites in categorizing captan as a probable human carcinogen was based on NTP list of acceptable organ combinations. (TR-015) 133-06-2
Proposed Rule Hazardous Waste Management System EPA proposed rule to amend RCRA regulations to list as hazardous 4 additional wastes from wood preserving and surface protection processes.

December 30, 1988 -- 53 FR 53282
Reference to NTP study demonstrating carcinogenicity of pentachlorophenol. (TR-349) 87-86-5
Proposed Rule Methyl Ethyl Ketoxime EPA proposed rule to require testing under TSCA Section 4.

September 15, 1988 -- 53 FR 35838
Reference to NTP study of methyl ethyl ketone. 78-93-3
Final Rule 2-Mercaptobenzothiazole EPA final rule to require testing under TSCA Section 4.

September 07, 1988 -- 54 FR 34514
NTP chronic and subchronic studies of MBT. (TR-332) 149-30-4
Notice Certain Chemicals in Anilines Category EPA notice of termination of rulemaking because there is no basis for finding of unreasonable risk of injury to health or the environment.

August 19, 1988 -- 53 FR 31814
Reference to study of 4-chloro-2-nitroaniline supported by NIEHS. 89-63-4
Final Rule Aniline & 7 Substituted Anilines EPA final rule regarding enforceable testing consent orders under TSCA.

August 19, 1988 -- 53 FR 31804
References to studies of p-chloroaniline and 4-nitroaniline supported by NIEHS. 106-47-8
100-01-6
20265-96-7
Proposed Rule Benzene EPA proposed rule on setting NESHAP applicable to benzene equipment leaks, ethylbenzene/styrene and maleic anhydride process vents, benzene storage vessels, and coke byproduct recovery plants.

July 28, 1988 -- 53 FR 28496
NTP 2-year chronic study of mice and rats orally exposed found significant incidence of cancers at multiple sites in both sexes and both species. (TR-289) 71-43-2
Proposed Rule Melamine EPA proposed rule to delete melamine from list of toxic chemicals for which toxic chemical release reporting is required under SARA Section 313.

June 20, 1988 -- 53 FR 23128
NTP bioassay resulted in statistically significant increase in carcinomas in male rats. (TR-245) 108-78-1
Notice RCRA Hazardous Waste Identification EPA notice regarding strategy for setting compound-specific dilution/attenuation factors in the Toxicity Characteristic used by waste generators to determine whether their solid wastes are hazardous.

May 19, 1988 -- 53 FR 18024
NTP studies of 1,4-dichlorobenzene, Pyridine, and Methylene Chloride (TR-306) (TR-319) (TR-283) 75-09-2
106-46-7
110-86-1
Notice Naphthalene EPA notice of assessment results under Clean Air Act, concluding that the health data base is insufficient to warrant regulation under the CAA.

March 21, 1988 -- 53 FR 9138
NTP 2-year inhalation study is currently in progress. (TR-410) 91-20-3
Proposed Rule Isopropanol EPA proposed rule to require testing under TSCA Section 4.

March 16, 1988 -- 53 FR 8638
"The only adequate study" of mutagenicity is a salmonella reverse mutation assay conducted by NTP. 67-63-0
Final Rule Diethylene Glycol Butyl Ether and Diethylene Glycol Butyl Ether Acetate EPA final rule to require testing under TSCA Section 4.

February 26, 1988 -- 53 FR 5932
NTP currently is conducting an oncogenicity study of structurally similar glycol ethers. 112-34-5
Notice Dichlorvos EPA notice of initiation of special review of determine whether registration should be cancelled or otherwise amended in light of carcinogenic and other health effects.

February 24, 1988 -- 53 FR 5542
"Based on the NTP oncogenicity studies and chronic toxicity studies, in conjunction with exposure assessments of dietary, worker, residential, and pet risks, EPA has determined that all uses of dichlorvos have met the criterion for initiation of Special Review." (TR-342) 62-73-7
Final Rule Commercial Hexane EPA final rule to require testing under TSCA Section 4.

February 05, 1988 -- 53 FR 3382
Description of NTP dosing regimen in discussion of subchronic test standards. 110-54-3
Final Rule Polyamine-epichlorohydrin FDA final rule amending food additive regulations concerning paper and paperboard components.

December 10, 1987 -- 52 FR 46744
Reference to NCI/NTP bioassay of 1,2-dichloroethane. (TR-055) 107-06-2
Notice CPSC statement of enforcement policy for household products containing methylene chloride.

September 14, 1987 -- 52 FR 34698
NTP inhalation bioassay showed clear evidence of carcinogenicity in female rats and male and female mice. (TR-306) 75-09-2
Final Rule 2-Ethylhexanol EPA final rule to require a 2-year oncogenicity bioassay under TSCA Section 4.

August 03, 1987 -- 52 FR 28698
Reference to studies of 2-Ethylhexanol supported by NIEHS. 104-76-7
Proposed Rule Butyl Benzyl Phthalate EPA proposed rule to delete this chemical from SARA Section 313 list of chemicals for which release reporting is required.

July 20, 1987 -- 52 FR 27226
NTP bioassay results constitute equivocal evidence of carcinogenicity. (TR-213) 85-68-7
Notice Ethylene Bisdithiocarbamate (EBDC) EPA notice of initiation of special review to determine whether regulatory action is required.

July 17, 1987 -- 52 FR 27172
NTP is currently conducting an oncogenicity study of ETU, a common contaminant, degradation product, and metabolite of EBDC. (TR-388) 96-45-7
Final Rule 1,2,4,5-Tetrachlorobenzene EPA final rule modifying the test substance purity requirements under TSCA Section 4.

July 15, 1987 -- 52 FR 26477
NTP-identified test material having 99+% purity not available to manufacturers. 95-94-3
Final Rule 8 Volatile Synthetic Organic Chemicals (VOC's) EPA final rule for National Primary Drinking Water Regulations setting maximum contaminant levels and monitoring requirements for 8 VOC's under the Safe Drinking Water Act (SDWA).

July 08, 1987 -- 52 FR 25690
NTP chronic bioassay of rats and mice showed clear evidence of carcinogenicity of para-dichlorobenzene, TR-319. 106-46-7
Notice Drinking Water EPA notice of 7 substituted contaminants on SDWA list of 83 contaminants.

July 08, 1987 -- 52 FR 25720
Dibromomethane (proposed for removal from list) is being considered for NTP testing. Ethylbenzene (proposed for addition to list) is being tested by NTP. 100-41-4
106-93-4
Final Rule Fluoroalkenes EPA final rule to require testing under TSCA Section 4.

June 08, 1987 -- 52 FR 21516
NTP subchronic inhalation study of vinylidene fluoride. 75-38-7
Final Rule Polyhalogenated Dibenzo-p-dioxins and Dibenzofurans (HDD and HDF) EPA final rule under TSCA to require testing for certain chemicals for HDD/HDF contamination.

June 05, 1987 -- 52 FR 21412
Decabromodiphenyl Oxide, in grade used in NTP research, is exempt from this rule because NTP studies showed equivocal evidence of carcinogenicity in male mice and no evidence in female mice. (TR-309) 1163-19-5
Final Rule 11-Aminoundecanoic Acid EPA final rule promulgating a significant new use rule under TSCA Section 5.

May 28, 1987 -- 52 FR 19860
NTP bioassay showed limited evidence of carcinogenicity in animals. (TR-216) 2432-99-7
Proposed Rule Cyclohexane EPA proposed rule on test standards and requirements under TSCA Section 4.

May 20, 1987 -- 52 FR 19096
Reference to study of cyclohexane supported by NIEHS. 110-82-7
Notice 2,4,5-Trichlorophenol EPA notice of intent to cancel registration as active ingredient for all uses.

April 29, 1987 -- 52 FR 15549
References to several NTP studies of 2,3,7,8-TCDD, a contaminant of 2,4,5-TCP. (TR-209) 1746-01-6
Proposed Rule P-Dichlorobenzene EPA proposed rule to regulate p-dichlorobenzene as a probable human carcinogen under the Safe Drinking Water Act by amending the Maximum Contaminant Level Goal (MCLG).

April 17, 1987 -- 52 FR 12876
Based upon the results of the above studies and specifically the conclusions of the NTP report (bioassay of p-dichlorobenzene), EPA is proposing to amend the MCLG. TR-319. 106-46-7
Final Rule 8 Polybrominated Biphenyls (PBB's) and Tris EPA final rule promulgating a significant new use rule under TSCA Section 5.

January 26, 1987 -- 52 FR 2699
Reference to NTP bioassay of polybrominated biphenyl mixture. TR-244. 67774-32-7
Notice Pentachlorophenol EPA notice of decision to cancel registrations for all products containing pentachlorophenol for all non-wood uses except pulp/paper mill, oil well operations, and cooling tower uses.

January 21, 1987 -- 52 FR 2282
EPA requested that NTP reexamine female rat liver lesions from NCI study. 87-86-5
Proposed Rule 2-Ethylhexanol EPA proposed rule on testing under TSCA Section 4.

December 19, 1986 -- 51 FR 45487
Reference to study of 2-Ethyl-1-hexanol supported by NIEHS. 104-76-7
Final Rule 2-Ethylhexanoic Acid EPA final rule to require testing under TSCA Section 4.

November 06, 1986 -- 51 FR 40318
Reference to NTP nomination of compounds containing the 2-ethylhexyl moiety for mutagenicity testing. 149-57-5
Notice 1,3-Dichloropropene EPA notice of special review of pesticides containing 1,3-dichloropropene.

October 08, 1986 -- 51 FR 36160
NTP gavage study showed clear evidence of carcinogenicity. TR-269. 542-75-6
Notice Nickel Subsulfide and Nickel Carbonyl EPA notice of determination that no Federal regulation is warranted at this time under CAA.

September 25, 1986 -- 51 FR 34135
NTP and NIEHS are currently conducting animal bioassays of selected nickel compounds. (TR-454) (TR-451) (TR-453) 10101-97-0
1313-99-1
12035-72-2
Other Guidelines for Assessing Health Risks of Environmental Pollutants EPA issuance of guidelines for carcinogen risk assessment, mutagenicity risk assessment, health risk assessment of chemical mixtures, and health assessment of suspect developmental toxicants.

September 24, 1986 -- 51 FR 33992
Each of these 4 EPA guidelines makes reference to NTP studies.
Final Rule Bisphenol A EPA final rule to require a 90-day inhalation subchronic toxicity study with particular emphasis on pulmonary effects, under TSCA Section 4.

September 18, 1986 -- 51 FR 33047
NTP oral gavage bioassay provides needed data to evaluate subchronic toxicity of PBA. TR-215. 80-05-7
Other Dioxin-containing wastes EPA denial of petition to amend rule listing certain dioxin-containing wastes as acute hazardous wastes.

September 15, 1986 -- 51 FR 32670
NTP bioassay study of HXCDD referred to in docket. TR-198. 57653-85-7
Final Rule 1,2-Dichloropropane EPA final rule to require testing under TSCS Section 4.

September 09, 1986 -- 51 FR 32079
NTP 2-year bioassay "is adequate to determine the oncogenic potential of DCP." Also notes NTP concern over DCP in drinking water as indicating need for oral exposure in testing. TR-263. 78-87-5
Final Rule Pentachloroethane EPA final rule promulgating a significant new use rule under TSCA Section 5.

September 09, 1986 -- 51 FR 32077
NTP bioassay demonstrated limited evidence of carcinogenicity in lab animals. TR-232. 76-01-7
Proposed Rule 1,1-Dichloroethylene EPA proposed rule to require testing under TSCA Section 4.

August 12, 1986 -- 51 FR 28840
NTP's 2-year gavage study was the "only study considered by EPA to have an adequate protocol to demonstrate a chemical's lack of oncogenic potential," although this study may not have achieved a sufficiently high dose." TR-228 75-35-4
Proposed Rule 11-Aminoundecanoic Acid EPA proposed rule promulgating a significant new use rule under TSCA Section 5.

July 22, 1986 -- 51 FR 26273
NTP carcinogenesis bioassay shows 11-AA induces malignant tumor response in male rats and also can cause non-oncogenic effects in lab animals. TR-216. 2432-99-7
Notice Toluenediamines EPA notice of termination of investigation of occupational exposure in light of evidence of carcinogenicity.

July 10, 1986 -- 51 FR 25070
Bioassays conducted under the NTP have demonstrated that 2,4-Toluenediamine causes cancer in lab animals. (TR-162) 95-80-7
Final Rule Chlorinated Benzenes EPA final rule to require testing under TSCA Section 4.

July 08, 1986 -- 51 FR 24657
NTP studies of 1,2,4,5-TCB, 1,2-DCB, & 1,4-DCB. (TR-319) (TR-255) 106-46-7
95-50-1
95-94-3
Proposed Rule 8 Polybrominated Biphenyls (PBB's) and Tris EPA proposed rule promulgating a significant new use rule under TSCA Section 5.

July 07, 1986 -- 51 FR 24555
Reference to NTP bioassay of polybrominated biphenyl mixture. TR-244. 67774-32-7
Final Rule Methylcyclopentane and Commercial Hexane EPA proposed rule to require testing under TSCA Section 4.

May 15, 1986 -- 51 FR 17854
NTP is conducting a subchronic inhalation toxicity test and is supporting reproductive and developmental toxicity testing. (TOX-02) 110-54-3
96-37-7
Final Rule Cresols EPA final rule to require testing under TSCA Section 4.

April 28, 1986 -- 51 FR 15771
NTP is planning range-finding and subchronic studies. (TOX-09) 1319-77-3
Proposed Rule Pentachloroethane EPA proposed rule promulgating a significant new use rule under TSCA Section 5. (Final rule published 9/9/86.)

March 24, 1986 -- 51 FR 10024
NTP bioassay demonstrated evidence of carcinogenicity in both sexes of rats and mice. TR-232. 76-01-7
Notice Perchloroethylene EPA correction of previous FR notice to assess perchloroethylene as a potentially toxic air pollutant under the Clean Air Act Section 112.

March 05, 1986 -- 51 FR 7718
NTP toxicology and carcinogenesis studies in rats and mice. TR-311. 127-18-4
Notice Formamide EPA notice of decision not to require further testing under TSCA Section 4, pursuant to federal district court ruling that EPA, in lieu of a negotiated testing agreement, require testing or give reasons for not requiring testing.

February 27, 1986 -- 51 FR 6929
NTP testing of formamide over 5 doses in 4 strains of salmonella; no indication of mutagenic activity seen. 75-12-7
Proposed Rule Hydroquinone EPA proposed rule on testing standards for hydroquinone.

December 30, 1985 -- 50 FR 53160
NTP 2-year gavage study will provide data for comparison with dermal contact data from required toxicokinetic studies. (TR-366) 123-31-9
Notice Perchloroethylene EPA notice of assessment of perc as a potentially toxic air pollutant and intent to list under CAA Section 112.

December 26, 1985 -- 50 FR 52880
NTP inhalation study, which showed a carcinogenic potential in male rats and both sexes of mice, "has resulted in this notice of intent to list." (TR-311) 127-18-4
Notice Trichloroethylene EPA notice of assessment of TCE as a potentially toxic air pollutant and intent to list under CAA Section 112. (This rule was clarified on 3/5/86.)

December 23, 1985 -- 50 FR 52422
"The conclusion that TCE is a probable carcinogen is based on the findings of the NCI (1976) and NTP (1982) mouse studies..." (TR-243) 79-01-6
Final Rule Hydroquinone EPA final rule requiring testing under TSCA Section 4.

December 20, 1985 -- 50 FR 53145
Carcinogenicity testing not required because NTP conducting 2-year bioassay. (TR-366) 123-31-9
Proposed Rule Hazardous Waste Management System EPA proposed rule to list used oil as hazardous waste.

November 29, 1985 -- 50 FR 49258
Reference to two NTP perchloroethylene inhalation studies of mice and rats which EPA is evaluating and expects to result in a B-2 classification of perc. (TR-311) 127-18-4
Final Rule Propylene Oxide EPA final rule to require testing for developmental toxicity under TSCA Section 4.

November 27, 1985 -- 50 FR 48762
NTP 2-year studies on rats and mice demonstrated evidence of carcinogenicity. (TR-267) 75-56-9
Proposed Rule Synthetic Organic Chemicals, Inorganic Chemicals, and Microorganisms EPA proposed rule to establish Recommended Maximum Contaminant Levels as part of the National Primary Drinking Water Regulation under the Safe Drinking Water Act.

November 13, 1985 -- 50 FR 46936
NTP studies of 1,2-dichloropropane; monochlorobenzene; dichlorobenzene; 1,2 dibromoethane; pentachlorophenol; toluene; xylene; 2,3,7,8-TCDD; and ingestion of asbestos. (TR-327) (TR-371) (TR-319) (TR-263) (TR-349) (TR-255) (TR-210) (TR-261) 1330-20-7
108-88-3
106-46-7
78-87-5
1746-01-6
87-86-5
95-50-1
106-93-4
108-90-7
12001-28-4
12001-29-5
12172-73-5
14567-73-8
Notice Volatile Synthetic Organic Chemicals EPA notice of new evidence and requests for comment on new NTP report on tetrachloroethylene.

November 13, 1985 -- 50 FR 47025
EPA reopened comment period specifically to provide opportunity for comment on NTP report. 127-18-4
Proposed Rule Pentabromoethylbenzene EPA proposed rule on testing under TSCA Section 4.

November 13, 1985 -- 50 FR 46785
NTP tests were performed using Salmonella typhimurium. 85-22-3
Final Rule Volatile Synthetic Organic Chemicals EPA final rule promulgating National Primary Drinking Water regulations.

November 13, 1985 -- 50 FR 46880
NTP rat and mice inhalation bioassay of tetrachloroethylene demonstrated carcinogenicity in both species. NTP gavage bioassay of p-dichlorobenzene showed carcinogenicity in both sexes of mice and female rats showed no evidence of carcinogenicity. (TR-319) (TR-311) 106-46-7
127-18-4
Proposed Rule 2-Mercaptobenzothiazole EPA proposed rule requiring testing under TSCA Section 4.

November 06, 1985 -- 50 FR 46121
NTP carcinogenesis study in progress. (TR-332) 149-30-4
Proposed Rule Fluoroalkenes EPA proposed rule requiring testing.

November 06, 1985 -- 50 FR 46133
NTP study of vinylidene fluoride. 75-38-7
Other Methylene Chloride EPA ANPR announcing initiation of comprehensive regulatory investigation.

October 17, 1985 -- 50 FR 42037
NTP inhalation bioassay demonstrated carcinogenicity in two species. (TR-306) 75-09-2
Notice 1,3-Butadiene EPA notice of intent to list under CAA Section 112 as a potentially toxic air pollutant.

October 10, 1985 -- 50 FR 41466
Reference to NTP mouse study which was prematurely terminated due to excess deaths. 106-99-0
Other 1,3-Butadiene EPA referral to OSHA under TSCA Section 9.

October 10, 1985 -- 50 FR 41393
Reference to NTP report on toxicological and carcinogenesis studies. (TR-288) 106-99-0
Other Dioxin-containing wastes EPA tentative denial of petition to amend the rule listing certain dioxin-containing wastes as acute hazardous wastes.

October 08, 1985 -- 50 FR 41125
Reference to NCI/NTP bioassay of HXCDD. (TR-202) 57653-85-7
Notice Hexachlorocyclopentadiene EPA notice of intent not to regulate and solicitation of information.

October 01, 1985 -- 50 FR 40154
Ongoing NTP study. (TR-437) 77-47-4
Notice Chloroprene EPA notice of intent not to regulate and solicitation of information.

September 27, 1985 -- 50 FR 39632
Ongoing NTP carcinogenicity and reproductive hazard study. 126-99-8
Proposed Rule Benzyl Butyl Phthalate EPA proposed test rule.

September 06, 1985 -- 50 FR 36446
NTP planned reproduction effects and cancer studies make it unnecessary to require health effects testing at this time. (TR-458) 85-68-7
Notice Chlorinated Benzenes EPA notice of intent not to regulate chlorinated benzenes under CAA.

August 13, 1985 -- 50 FR 32628
NTP carcinogenesis testing of 1,4-dichlorobenzene is currently underway. (TR-319) 106-46-7
Other Manganese EPA decision not to regulate manganese under CAA.

August 13, 1985 -- 50 FR 32627
Regulation not needed at this time because NTP has scheduled carcinogenicity testing and is conducting mutagenicity studies. (TR-428) 10034-96-5
Proposed Rule 4,4-Methylenedianiline EPA notice of decision to refer to OSHA under TSCA Section 9.

July 05, 1985 -- 50 FR 27674
NTP study demonstrated that dihydrochloride salt of 4,4-MDA is carcinogenic in both sexes of rats and mice. (TR-248) 13552-44-8
Notice Methyl Chloroform EPA notice of assessment as a potentially toxic air pollutant and determination that regulation under CAA is not warranted.

June 10, 1985 -- 50 FR 24314
EPA awaiting results of NTP carcinogenicity bioassay. (TR-262) 71-55-6
Final Rule Diethylenetriamine EPA final rule on testing requirements under TSCA Section 4.

May 23, 1985 -- 50 FR 21398
NTP conducted Ames Salmonella/Microsome Plate Test with negative results. 111-40-0
Final Rule 2-Ethylhexanoic Acid EPA proposed rule on testing under TSCA Section 4.

May 17, 1985 -- 50 FR 20679
NTP tests of four chemicals containing 2-ethylhexyl showed them to be animal oncogenes; NTP plans test of 2-ethylhexanol. 104-76-7
Proposed Rule Bisphenol A EPA proposed rule on testing under TSCA Section 4.

May 17, 1985 -- 50 FR 20691
"EPA finds that sufficient data are available from the NTP bioassay report to reasonably predict that ingested BPA is not oncogenic...EPA believes appropriate developmental toxicity testing has been conducted at NTP." (TR-215) 80-05-7
Notice Cyromazine EPA notice of determination to issue conditional registration under FIFRA.

May 15, 1985 -- 50 FR 20373
NTP bioassay demonstrated that high dose ingestion induced cancer. NTP study of Melamine, a metabolite of Cyromazine. (TR-245) 108-78-1
Notice Methylene Chloride EPA notice of initiation of accelerated review under TSCA Section 4.

May 14, 1985 -- 50 FR 20126
NTP inhalation studies demonstrated carcinogenicity. (TR-306) 75-09-2
Final Rule Dioxin-containing Wastes EPA final rule listing certain dioxin-containing wastes as acute hazardous wastes.

January 14, 1985 -- 50 FR 1978
Re-evaluation by NTP of NCI study of HXCDD. (TR-202) 57653-85-7
Proposed Rule Certain Polyamino Chemical Substances EPA proposed rule promulgating a significant new use rule under TSCA Section 5.

December 27, 1984 -- 49 FR 50209
NTP bioassay indicated that the dihydrochloride salt of Methylenedianiline is carcinogenic in both sexes of rats and mice. (TR-248) 13552-44-8
Proposed Rule [(Dinitrophenyl)Azo]-[2,4-Diamino-5-Methoxybenzene] Derivatives; Proposed Determination of Significant New Uses EPA proposed rule promulgating a significant new use rule under TSCA Section 5.

October 25, 1984 -- 49 FR 42960
NTP and others have shown carcinogenic potential of close structural analogues of phenylenediamines.
Final Rule 1,1,1-Trichloroethane EPA final rule identifying specific chemical substance and mixture testing requirements.

October 10, 1984 -- 49 FR 39810
EPA did not propose chronic effects or oncogenicity testing because an NTP study is expected to provide sufficient information. (TR-262) 71-55-6
Proposed Rule Dichloromethane EPA proposed rule to withdraw testing requirements under TSCA. Evaluation of data indicates dichloromethane does not present unreasonable risks.

June 19, 1984 -- 49 FR 25009
EPA expects NTP inhalation bioassay to be sufficient to characterize oncogenic hazards. (TR-306) 75-09-2
Proposed Rule Nitrobenzene EPA proposed rule to withdraw testing requirements under TSCA. Ongoing government and manufacturers' tests are expected to meet all testing.

June 19, 1984 -- 49 FR 25013
EPA concluded that NTP oncogenicity and subchronic effects testing would be sufficient and so didn't require further testing for these effects. 98-95-3
Proposed Rule Volatile Synthetic Organic Chemicals EPA proposed rule for National Primary Drinking Water Regulations establishing Recommended Maximum Contaminant Levels for several VOC's.

June 12, 1984 -- 49 FR 24330
NTP studies of trichlorethylene; 1,1,1-trichlorethane; 1,1-dichloroethylene; and p-dichlorobenzene. (TR-319) (TR-228) (TR-243) (TR-273) (TR-262) 106-46-7
79-01-6
71-55-6
75-35-4
Proposed Rule Fluoroalkenes EPA notice of proposed decision to adopt a negotiated testing program in lieu of required testing.

June 04, 1984 -- 49 FR 23112
NTP planning testing of tetrafluoroethane and vinylidene. (TR-228) 75-35-4
Notice Bis(2-Ethylhexyl) Terephthalate EPA notice of decision to adopt negotiated testing program.

June 04, 1984 -- 49 FR 23110
NTP has nominated two chemicals similar to the metabolites of DOTP for genotoxicity testing. 104-76-7
4376-20-9
Notice Toluene EPA notice of decision not to regulate under CAA based on studies showing toluene not to pose a significant risk to public health. This decision is not relevant to regulation of toluene as a VOC under the air quality standards for ozone.

May 25, 1984 -- 49 FR 22195
NTP is currently conducting a lifetime bioassay on toluene. (TR-371) 108-88-3
Other Formaldehyde EPA ANPR announcing decision that TSCA Section 4f priority consideration is applicable in 2 exposure categories, and initiating a regulatory investigation.

May 23, 1984 -- 49 FR 21870
Federal Panel on Formaldehyde, under the aegis of NTP, reviewed CIIT's bioassay methodology from CIIT inhalation study showing nasal cancer in rats. 50-00-0
Notice Calcium, Cobalt, and Lead Napthenates EPA notice of determination not to require testing.

May 21, 1984 -- 49 FR 21411
NTP planning testing of cobalt naphthenate and cobalt sulfate; NTP currently testing naphthenic acid; NTP has completed mutagenicity tests of lead naphthenate. 10124-43-3
61789-51-3
Other 1,3-Butadiene EPA ANPR and invitation to submit data on controlling exposures, following recent bioassays establishing carcinogenicity.

May 15, 1984 -- 49 FR 20524
NTP chronic oncology studies show carcinogenicity in both sexes of rats and mice; NTP planning further teratology testing. (TR-288) 106-99-0
Proposed Rule Cyromazine EPA proposed temporary feed additive regulation.

April 27, 1984 -- 49 FR 18130
NTP bioassay of Melamine, a metabolite of Cyromazine, showed significant increase in bladder carcinomas in male rats. (TR-245) 108-78-1
Notice Cyromazine EPA proposed rule to establish feed additive regulation setting temporary maximum permissible residue level in poultry feed.

April 27, 1984 -- 49 FR 18120
NTP bioassay of Melamine, a metabolite of Cyromazine, showed a significant increase in bladder carcinomas in male rats. (TR-245) 108-78-1
Notice Cyromazine EPA notice of proposed conditional registration under FIFRA for temporary period.

April 27, 1984 -- 49 FR 18172
As a result of the reported oncogenicity of Melamine in the NTP bioassay, the agency stopped the Cyromazine registration process...until it could review the NTP bioassay. (TR-245) 108-78-1
Notice Isophorone EPA notice of decision to adopt negotiated testing program.

January 17, 1984 -- 49 FR 2012
NTP's initiation of a long-term bioassay, together with CMA proposed testing, make it unnecessary to require TSCA Section 4 testing. (TR-291) 78-59-1
Proposed Rule 1,2-Dichloropropane EPA proposed test rule

January 06, 1984 -- 49 FR 899
NTP 2-year bioassay (TR-263) 78-87-5
Notice 1,2-Butylene Oxide EPA notice of determination not to require testing.

January 04, 1984 -- 49 FR 503
NTP inhalation bioassay of 1,2-butylene oxide. (TR-329) 106-88-7
Other Certain Alkyl Epoxides EPA ANPR on testing under TSCA

January 04, 1984 -- 49 FR 449
NTP subchronic study on 1,2-Epoxyhexadecane applied dermally. 7320-37-8
Proposed Rule Hydroquinone EPA Proposed test rule under TSCA Section 4.

January 04, 1984 -- 49 FR 438
EPA is not proposing oncogenicity testing of Hydroquinone since NTP is currently conducting a 2-year bioassay. (TR-366) 123-31-9
Notice Ethylene Oxide EPA notice of determination not to require testing.

January 03, 1984 -- 49 FR 200
NTP chronic inhalation bioassay. (TR-326) 75-21-8
Other Anilines EPA ANPR to require health and environmental effects testing.

January 03, 1984 -- 49 FR 108
NTP confirmatory study of effects of dietary exposure to 4-Chloroaniline Hydrochloride. (TR-351) 20265-96-7
Proposed Rule Hexafluoropropylene Oxide EPA proposed test rule under TSCA Section 4.

December 30, 1983 -- 48 FR 57686
NTP planning to conduct Ames assay. 428-59-1
Proposed Rule Cyromazine EPA issuance of emergency exemptions for use of an unregistered pesticide.

December 14, 1983 -- 48 FR 55624
Applicant's earlier request for specific exemption was denied because of results of NTP study of Melamine, a metabolite of Cyromazine. 108-78-1
Proposed Rule Chlorinated Benzenes EPA proposed rule to withdraw most testing requirements.

December 07, 1983 -- 48 FR 54836
NTP mutagenesis testing of Monochlorobenzene; 1,2,4-Trichlorobenzene and Pentachlorobenzene. NTP toxicity testing of Monochlorobenzene,ortho and para-Dichlorobenzenes. (TR-255) (TR-261) 120-82-1
108-90-7
608-93-5
95-50-1
Notice Formaldehyde EPA notice of reconsideration as to whether TSCA Section 4f priority consideration is appropriate.

November 18, 1983 -- 48 FR 52507
Federal Panel on Formaldehyde, formed by several agencies under the aegis of NTP, reviewed study of Formaldehyde. 50-00-0
Notice Bis(2-Ethylhexyl)Terephthalate; Response to the Interagency Testing Committee EPA notice that it is not initiating TSCA Section 4 test requirement rulemaking because ongoing tests are expected to provide sufficient information to predict toxicity.

November 14, 1983 -- 48 FR 51845
Two chemicals similar to metabolites of DOTP have been nominated for genotoxicity testing by the NTP. 104-76-7
4376-20-9
Notice Tris EPA notice that it is not initiating TSCA Section 4A test requirement rulemaking because ongoing tests are expected to provide sufficient information to predict toxicity.

November 14, 1983 -- 48 FR 51842
NTP testing of compounds containing the 2-ethylhexyl moiety. (TR-274) 78-42-2
Notice 4,4-Methylenedianiline EPA ANPR of EPA/OSHA joint initiation of regulatory action under TSCA and OSHA Act.

September 20, 1983 -- 48 FR 42898
NTP bioassay indicated that the dihydrochloride salt of 4,4-MDA is carcinogenic in both sexes of rats and mice. (TR-248) 13552-44-8
Notice 4,4-Methylenedianiline EPA notice that it is not initiating a TSCA Section 4A health effects test rule because recent NTP study shows MDA to be carcinogenic in rats and mice.

July 11, 1983 -- 48 FR 31806
The data from the NTP bioassay are sufficient...and further oncogenicity testing is unnecessary. (TR-248) 13552-44-8
Notice Formamide EPA notice of determination not to require additional health effects testing.

May 23, 1983 -- 48 FR 23098
NTP genotoxicity testing, together with importer's subchronic effects testing, make it unnecessary to require Section 4A testing. 75-12-7
Notice Isophorone EPA notice that it is not initiating TSCA Section 4A test requirements because of adequate ongoing tests.

January 06, 1983 -- 48 FR 727
NTP long-term bioassay, together with manufacturers' tests, make it unnecessary to require Section 4A testing. (TR-291) 78-59-1
Notice Acetonitrile EPA notice that testing by NTP and manufacturers is adequate and further testing under TSCA Section 4 is not warranted.

December 29, 1982 -- 47 FR 58020
NTP chronic and mutagenic effects testing, together with manufacturers' testing, make it unnecessary to require Section 4A testing. (TR-447) 75-05-8
Notice Pyridine EPA notice that testing under TSCA Section 4 is not warranted.

December 29, 1982 -- 47 FR 58031
Sufficient data have been or are being developed on Pyridine for carcinogenicity and chronic effects by the NTP. (TR-283) 110-86-1
Notice Hexachlorocyclopentadiene EPA notice that testing under TSCA Section 4 is not warranted.

December 29, 1982 -- 47 FR 58023
NTP is conducting a 2-year inhalation oncogenicity bioassay. (TR-437) 77-47-4
Notice Xylenes EPA notice that testing under TSCA Section 4 is not warranted.

December 16, 1982 -- 47 FR 56392
NTP cancer bioassay and teratogenicity study of mixed Xylenes. 1330-20-7
Notice Toluene EPA notice that a test rule under TSCA Section 4 is unnecessary because information from current and planned testing will be sufficient.

December 16, 1982 -- 47 FR 56391
NTP has completed a subchronic oral study and NTP/NCI carcinogenesis testing program is starting chronic studies. 108-88-3
Final Rule Asbestos EPA final rule requiring schools to identify friable asbestos-containing building materials, to maintain records, and to notify employees and PTA's.

May 27, 1982 -- 47 FR 23360
Reference to report on Amosite, Chrysotile, Crocidolite and nonfibrous Tremolite for NIEHS oral ingestion studies. 12001-28-4
12001-29-5
14567-73-8
1332-21-4
12172-73-5
Notice Chlorinated Paraffins EPA notice that testing under TSCA Section 4 is not being required because currently planned testing is sufficient.

January 08, 1982 -- 47 FR 1017
NTP bioassays of two chlorinated paraffin compounds. (TR-305) (TR-308) 108171-27-3
108171-26-2
Notice Benzidine, o-Tolidine, o-Dianisidine EPA notice that testing under TSCA Section 4 is not required due to adequacy of current testing programs of NTP and other federal agencies.

November 05, 1981 -- 46 FR 55004
Current and planned testing by NTP cited. 92-87-5
119-93-7
Other Alkyl Phthalate and Benzyl Butyle Phthalate EPA notice of preliminary decision not to require testing under TSCA, following receipt of CMA testing proposal.

October 30, 1981 -- 46 FR 53775
NTP conducting mutagenicity, oncogenicity, and reproductive and mitochondrial effects studies of various alkyl phthalate esters. 85-68-7
Other Asbestos EPA proposed rule to require schools to identify friable asbestos-containing materials and to notify employees and PTAs.

September 17, 1980 -- 45 FR 61966
NIEHS-sponsored studies of effects of asbestos exposure. 1332-21-4
Proposed Rule Chloromethane and Chlorinated Benzenes EPA proposed rule to require testing under TSCA Section 4.

July 18, 1980 -- 45 FR 48524
NTP has selected 1,4-Dichlorobenzene for teratogenicity testing. 106-46-7

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Food and Drug Administration (FDA)

Notice Type Title Summary of Notice NTP Information Cited CASRN
Final Rule 4,4'-Diphenylmethanediamine FDA final rule amending food additive regulations to allow use of polyamide-imide resins in articles which come into contact with food.

October 23, 1989 -- 54 FR 43168
Data from NTP carcinogenesis bioassay used to estimate upper-bound level of lifetime risk from proposed use of 4,4'-diiphenylmethanediamine.
Final Rule Methylene Chloride (75-09-2) FDA final rule banning use of methylene chloride as an ingredient of cosmetic products.

June 29, 1989 -- 54 FR 27328
NTP concluded with respect to their inhalation study on methylene chloride that there was clear evidence of carcinogenicity in mice and female rats and some evidence of carcinogenicity in male rats. 75-09-2
Final Rule Dimethyl Dicarbonate FDA final rule amending food additive regulations to allow use as yeast inhibitor in wines.

October 21, 1988 -- 53 FR 41325
NTP carcinogenesis bioassay of methyl carbamate which is produced in food by dimethyl dicarbonate. (TR-328) 598-55-0
Final Rule D& C Red No. 36 FDA final rule permanently listing D Red No. 36 for general use except in eye area.

August 02, 1988 -- 53 FR 29024
At FDA's request, NTP compared data on D Red No. 33 with D Red No. 9, a splenic carcinogen. (Nos. 33 and 36 were being considered jointly). (TR-225) 5160-02-1
Notice D& C Red No. 8 and D& C Red No. 9 FDA notice of denial of petition for listing for use in ingested lip products and in externally applied drugs and cosmetics.

July 15, 1988 -- 53 FR 26886
NCI/NTP chronic rat study concluded that D Red No. 9 is carcinogenic for male F-344 rats. (TR-225) 5160-02-1
Final Rule Cancer-Causing Residues in Edible Products of Food-Producing Animals FDA final rule on procedures and criteria to ensure absence of such residues in animals to which drugs, food additives, or color additives have been administered.

December 31, 1987 -- 52 FR 49572
References to NTP report on chemical carcinogenesis testing and evaluation.
Final Rule Indirect Food Additives FDA final rule allowing use of an additive to paper products which come into contact with food, although the additive may contain minute amounts of methylene chloride as a byproduct of its production.

May 27, 1987 -- 52 FR 19722
NTP-supported study of methylene chloride showed carcinogenicity in male and female mice. TR-306. 75-09-2
Final Rule D& C Red No. 8 and No. 9 FDA final rule permanently listing D Red No. 8 and No. 9 as color additives for use in lip products & externally applied drugs and cosmetics.

December 05, 1986 -- 51 FR 43877
This regulation, based on a deminimus interpretation of the Delaney Clause was revoked following a federal court ruling. 5160-02-1
Final Rule FD& C Yellow No. 6 FDA final rule permanently listing FD Yellow No. 6 for use in food, drugs, and cosmetics.

November 19, 1986 -- 51 FR 41765
"With the exception of the 1981 NCI/NTP bioassays that were done, the agency considered past studies as inadequate.." (TR-208) 2783-94-0
Final Rule Listing of D& C Orange No. 17 for Use in Externally Applied Drugs and Cosmetics FDA final rule permanently listing D Orange No. 17 as a color additive for use in externally applied drugs and cosmetics.

August 07, 1986 -- 51 FR 28331
NTP publication cited reporting 50% of 86 compounds tested by NTP between 7/81-7/84 were determined to induce some carcinogenic effect.
Proposed Rule Methylene Chloride FDA proposed rule to ban use in cosmetic products.

December 18, 1985 -- 50 FR 51551
NTP studies concluded that methylene chloride is a carcinogen in mice and can induce cancer at sites remote from the site of administration. (TR-306) 75-09-2
Final Rule Cinnamyl Anthranilate FDA final rule prohibiting use in human food.

October 23, 1985 -- 50 FR 42929
NTP panel on Chemical Carcinogenesis Testing and Evaluation recommended continued use of the B55526 C55523 and F55521 mouse. 87-29-6
Final Rule Certain Color Additives FDA final rule postponing closing dates for provisional listing of certain color additives to allow uninterrupted use while scientific evaluation continues.

September 04, 1985 -- 50 FR 35783
NTP found a clear relationship between D Red No. 9, which has indicated carcinogenic effects and D Red No. 33 that provides a basis for concern about the possible carcinogenicity of No. 33. (TR-225) 5160-02-1
Final Rule Irradiation of Food FDA final rule to permit gamma radiation of pork to control Trichinella Spiralis, citing NTP study which concluded that histopathological data did not show a carcinogenic response.

July 22, 1985 -- 50 FR 29658
NTP review, conducted at FDA's request, concluded that data did not demonstrate a carcinogenic response.
Proposed Rule Certain Color Additives FDA proposed rule to postpone closing dates on provisional listing of certain color additives.

June 26, 1985 -- 50 FR 26377
NTP examined data on D Red Nos. 9 and 33 and concluded that there is a relationship between them that provides a basis for concern about the possible carcinogenicity of No. 33. (TR-225) 5160-02-1
Final Rule Irradiation of Food FDA final rule to permit irradiation of dry or dehydrated enzyme preparations.

June 10, 1985 -- 50 FR 24190
NTP review, conducted at FDA's request, concluded that data did not demonstrate a carcinogenic response.
Final Rule Irradiation of Food FDA final rule to permit irradiation of additional herbs, spices, and vegetable seasonings.

April 18, 1985 -- 50 FR 15415
FDA has referred USDA study to NTP for peer review. N/A
Other Carcinogenic Chemicals in Food and Color Additives FDA ANPR on setting a policy for regulating use of food and color additives containing carcinogens.

April 02, 1982 -- 47 FR 14464
Reference to NIEHS report on species to species comparison of carcinogenicity data.

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Mine Safety and Health Administration (MSHA)

Notice Type Title Summary of Notice NTP Information Cited CASRN
Proposed Rule Lead MSHA proposed rule to revise standards for air quality and chemical substances in mines.

August 29, 1989 -- 54 FR 35760
NTP recommendation that lead oxide and lead sulfide be ranked a high priority for acute toxicity studies cited in support of proposed lead exposure standard. 1317-36-8
1314-87-0

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Occupational Safety and Health Administration (OSHA)

Notice Type Title Summary of Notice NTP Information Cited CASRN
Proposed Rule 4,4'-Methylenedianiline (13552-44-8) OSHA proposed rule to establish an 8-hour time-weighted average (TWA) of 10ppb, a short-term exposure limit (STEL) of 100PPB, and associated provisions.

May 12, 1989 -- 54 FR 20672
The OSHA-established MDA Advisory Committee used the NTP study "as the principal basis for its carcinogenicity findings." (TR-248) 13552-44-8
Notice Methylene Chloride (75-09-2) OSHA agenda notice to planned NPRM setting new standard for occupational exposure.

April 24, 1989 -- 54 FR 16873
This regulatory action is in response to a petition based on information from NTP and EPA. 75-09-2
Final Rule Air Contaminants OSHA final rule amending the air contaminants standard, including new table of Permissible Exposure Limits (PEL).

January 19, 1989 -- 54 FR 2332
NTP research cited includes bioassay of perchloroethylene and propylene oxide. (TR-311) (TR-267) 127-18-4
75-56-9
Final Rule Benzene OSHA final rule revising existing occupational standard to reduce PEL (Permissible Exposure Limit) from 10 ppm to 8-hr TWA (time weighted average) of 1 ppm and short-term exposure limit of 5 ppm.

September 11, 1987 -- 52 FR 34460
NTP 2-year inhalation bioassay; TR-289 71-43-2
Other Methylene Chloride OSHA ANPR to revise occupational health exposure standards.

November 24, 1986 -- 51 FR 42257
"The NTP bioassays have provided clear evidence of carcinogenicity in female rats and in both sexes of mice." TR-306. 75-09-2
Other 1,3-Butadiene OSHA ANPR to reduce occupational exposure.

October 01, 1986 -- 51 FR 35003
"OSHA has determined that the magnitude of the carcinogenicity evidence in the NTP animal study, almost 100% of the exposed animals developed tumors, warrants regulatory action." (TR-288) 106-99-0
Final Rule Asbestos, Tremolite, Anthrophyllite, and Actinolite OSHA final rule amending standard for occupational exposure and establishing a PEL.

June 20, 1986 -- 51 FR 22612
NTP studies involved oral administration of chrysotile, amosite, tremolite and crocidolite asbestos to lab animals. 12001-28-4
14567-73-8
12172-73-5
Notice 1,3-Butadiene OSHA notice responding to EPA referral under TSCA Section 9 and announcing preliminary conclusion that current PEL should be revised.

April 11, 1986 -- 51 FR 12526
"The magnitude of the carcinogenicity evidence in the NTP animal studies warrants regulatory action." (TR-288) 106-99-0
Notice 4,4'-Methylenedianiline (MDA) OSHA notice responding to EPA referral of MDA under TSCA Section 9 and announcing determination that the risk described by EPA may be eliminated or reduced by a workplace standard.

February 26, 1986 -- 51 FR 06748
"The most persuasive study has been conducted by the National Toxicology Program" in leading OSHA "to the conclusion that this chemical is carcinogenic in animals and may be carcinogenic to humans." (TR-248) 13552-44-8
Final Rule Benzene OSHA proposed rule on occupational exposure to benzene to reduce PEL from 10 ppm to 8-hr TWA to 1 ppm to reduce risk of leukemia and other adverse health consequences.

December 10, 1985 -- 50 FR 50512
"NTP has demonstrated statistically significant, dose-dependent increase in tumors of multiple sites for both sexes of two species." (TR-289) 71-43-2
Other Ethylene Oxide OSHA final standard on occupational PEL.

June 22, 1984 -- 49 FR 25734
NTP studies show significance of all malignancies rather than increases in only certain types of cancer, in calculating human risk. (TR-326) 75-21-8
Notice Hazard Communication OSHA final rule setting final occupational safety and health standard requiring hazard assessment and communication to employees of chemical hazard information.

November 25, 1983 -- 48 FR 53280
For purposes of hazard communication, OSHA defines a carcinogen as any substance found to be a confirmed or suspected carcinogen by NTP, IARC, or OSHA itself. N/A
Notice Asbestos OSHA emergency temporary standard to reduce occupational PEL.

November 04, 1983 -- 48 FR 51086
NTP studies in which Chrysotile, Amosite, Tremolite, and Crocidolite in feed were administered to lab animals with no increased incidence of tumors. 12001-28-4
12001-29-5
12172-73-5
14567-73-8
1332-21-4
Notice Ethylene Dibromide OSHA NPRM to revise current occupational exposure standard to reduce PEL, restrict dermal exposure, etc.

October 07, 1983 -- 48 FR 45956
NTP/NCI inhalation bioassay concluded that EDB was carcinogenic to rats. (TR-210) 106-93-4

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United States Department of Agriculture (USDA)

Notice Type Title Summary of Notice NTP Information Cited CASRN
Final Rule Irradiation of Pork USDA final rule to permit gamma radiation to control Trichinella Spiralis.

January 15, 1986 -- 51 FR 1769
NTP review of histopathology data on mice fed irradiated chicken, requested by FDA, concluded that data did not demonstrate a carcinogenic response.

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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.