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Regulatory Actions for Year 1992

Year Agency Title CASRN
1992 CPSC
Dioxin-containing Wastes

Issued guidelines specifying criteria for determining when any customary or reasonably foreseeable use of an art material can result in chronic hazard.

NTP Information Cited
NTP criteria for assessing the quality and adequacy of animal studies.

  • Type: Final Rule
  • October 09, 1992
  • 57 FR 46624
1992 OSHA
Occupational Exposure to Cadmium

OSHA publishes a new standard for occupational exposure to cadmium.

NTP Information Cited
Clear evidence of carcinogenicity of cadmium in animals was based on NTP's definition of clear evidence of carcinogenicity from the Report of the NTP Ad Hoc Panel on Chemical Carcinogenesis Testing and Evaluation.

  • Type: Final Rule
  • September 14, 1992
  • 57 FR 42102
1992 EPA
Chemicals: Toxic Chemical Release Reporting; Community Right-To-Know; Proposed Significant New Use Rule

The EPA is partially granting a petition submitted by the Governor of New York to add 80 chemicals and 2 chemical categories to the list of toxic chemicals subject to reporting under section 313 of the Emergency Planning and Community Right-To-Know Act by proposing to add 68 chemicals and 2 chemical categories.

NTP Information Cited
The EPA used several NTP bioassays as sources of information. (TOX-18) (TR-403) (TR-314) (TR-237) (TR-039) (TR-00A)

  • Type: Final Rule
  • September 08, 1992
  • 57 FR 41020
1338-23-4
108-46-3
80-62-6
630-20-6
303-34-4 148-82-3
1992 FDA
Indirect Food Additives: Paper and Paperboard Components

The FDA is amending the food additive regulations to provide for the safe use of ethyl acrylate in the manufacture of paper and paperboard intended for use in contact with food.

NTP Information Cited
The FDA used data from TR-259 on ethyl acrylate to estimate the upper-bound limit of lifetime human risk from exposure.

  • Type: Final Rule
  • August 07, 1992
  • 57 FR 34865
140-88-5
1992 EPA
Drinking Water: National Primary Drinking Water Regulations-Synthetic Organic Chemicals and Inorganic Chemicals; National Primary Drinking Water Regulations Implementation

EPA is promulgating maximum contaminant level goals and National Primary Drinking Water Regulations for 18 synthetic organic and 5 inorganic chemicals.

NTP Information Cited
The MCLG for Di(2-ethylhexyl)adipate was derived from the NTP 2-year dietary study, TR-212. The classification of DEHP as a Group B2 (probable human) carcinogen was based on the NTP 2-year study, (TR-217)

  • Type: Final Rule
  • July 17, 1992
  • 57 FR 31776
117-81-7
103-23-1
1992 EPA
Thirtieth Report of the Interagency Testing Committee: Request for Comments Regarding Priority Testing List of Chemicals

The Priority Testing List was revised by adding one chemical group, the siloxanes, and four chloralkyl phosphates.

NTP Information Cited
At the request of the NTP, TSCA Section 8(d) reports on health effects of bis-(4-chlorophenyl) sulfone were provided to facilitate NTP's evaluation of this chemical.

  • Type: Notice
  • July 09, 1992
  • 57 FR 30608
80-07-9
1992 OSHA
Air Contaminants

Health Effects of Substances to be Regulated

NTP Information Cited
OSHA used data from several NTP studies. (TR-363) (TR-228) (TR-263) (TR-382) (TR-273) (TR-311) (TR-362) (TR-217) (TR-267) (TR-314) (TR-349) (TR-251) (TR-376)

  • Type: Proposed Rule
  • June 12, 1992
  • 57 FR 26042
74-96-4
75-35-4
78-87-5
98-01-1
79-01-6 127-18-4
106-87-6
96-18-4
117-81-7
75-05-8
75-56-9
80-62-6
87-86-5
26471-62-5
106-92-3
1992 OSHA
Occupational Exposure to Methylene Chloride

Notice of informal public hearings concerning OSHA's proposal to modify the existing provisions for controlling employee exposure to methylene chloride.

NTP Information Cited
OSHA based its preliminary estimate of human cancer risk on the NTP mouse study. (TR-306)

  • Type: Proposed Rule
  • June 09, 1992
  • 57 FR 24438
75-09-2
1992 EPA
Draft Report: A Cross-Species Scaling Factor for Carcinogen Risk Assessment Based on Equivalence of mg/kg 3/4/day

The EPA, FDA, and CPSC are asking for public comments on a draft report: A Cross-Species Scaling Factor for Carcinogen Risk Assessment Based on Equivalence of mg/kg/3/4/day.

NTP Information Cited
Data from NCI/NTP bioassays were used to develop the report.

  • Type: Notice
  • June 05, 1992
  • 57 FR 24152
1992 EPA
Ethylene Bisdithiocarbamates: Notice of Intent to Cancel; Conclusion of Special Review

The EPA concludes the Special Review and risk/benefit analysis of EBDCs and announces the intent to cancel registrations and to deny applications for registration for all pesticide products containing EBDCs as an active ingredient unless the registrations/applications comply with the terms and conditions of registration set forth in this Notice. The Agency has determined that use will result in unreasonable adverse effects to humans or the environment.

NTP Information Cited
Data from the NTP bioassay on ethylene thiourea (ETU) were used by the EPA (TR-388)

  • Type: Notice
  • March 02, 1992
  • 57 FR 7484
96-45-7
1992 FDA
Indirect Food Additives: Polymers

The FDA is amending the food additive regulations to provide for the safe use of polyestercarbonate resin.

NTP Information Cited
Residual amounts of methylene chloride have been found in the additive. The FDA estimated the worst-case exposure to methylene chloride from the use of polyestercarbonate resin food-contact articles to be less than 15 micrograms per person per day. The FDA used data from TR-306 to estimate the upper-bound limit of lifetime human risk exposure to methylene chloride.

  • Type: Final Rule
  • February 03, 1992
  • 57 FR 3938
75-09-2
1992 EPA
Aryl Phosphate Base Stocks; Proposed Test Rule Including Reporting and Record-keeping Requirements

EPA proposes that manufacturers, importers and processors of chemical substances in the category of aryl phosphate base stocks be required, under section 4 of the Toxic Substances Control Act to conduct testing.

NTP Information Cited
Reproductive toxicity was demonstrated in the continuous breeding protocol in Swiss mice (1988). The EPA will examine the results of the NTP 2-year bioassay on TCP before deciding whether further oncogenicity testing on any other aryl phosphate is needed. (TR-433)

  • Type: Proposed Rule
  • January 17, 1992
  • 57 FR 2138
1330-78-5