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Regulatory Actions for Year 1992


Consumer Product Safety Commission (CPSC)

Notice Type Title Summary of Notice NTP Information Cited CASRN
Final Rule Dioxin-containing Wastes Issued guidelines specifying criteria for determining when any customary or reasonably foreseeable use of an art material can result in chronic hazard.

October 09, 1992 -- 57 FR 46624
NTP criteria for assessing the quality and adequacy of animal studies.

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Environmental Protection Agency (EPA)

Notice Type Title Summary of Notice NTP Information Cited CASRN
Final Rule Chemicals: Toxic Chemical Release Reporting; Community Right-To-Know; Proposed Significant New Use Rule The EPA is partially granting a petition submitted by the Governor of New York to add 80 chemicals and 2 chemical categories to the list of toxic chemicals subject to reporting under section 313 of the Emergency Planning and Community Right-To-Know Act by proposing to add 68 chemicals and 2 chemical categories.

September 08, 1992 -- 57 FR 41020
The EPA used several NTP bioassays as sources of information. (TOX-18) (TR-403) (TR-314) (TR-237) (TR-039) (TR-00A) 1338-23-4
108-46-3
80-62-6
630-20-6
303-34-4
148-82-3
Final Rule Drinking Water: National Primary Drinking Water Regulations-Synthetic Organic Chemicals and Inorganic Chemicals; National Primary Drinking Water Regulations Implementation EPA is promulgating maximum contaminant level goals and National Primary Drinking Water Regulations for 18 synthetic organic and 5 inorganic chemicals.

July 17, 1992 -- 57 FR 31776
The MCLG for Di(2-ethylhexyl)adipate was derived from the NTP 2-year dietary study, TR-212. The classification of DEHP as a Group B2 (probable human) carcinogen was based on the NTP 2-year study, (TR-217) 117-81-7
103-23-1
Notice Thirtieth Report of the Interagency Testing Committee: Request for Comments Regarding Priority Testing List of Chemicals The Priority Testing List was revised by adding one chemical group, the siloxanes, and four chloralkyl phosphates.

July 09, 1992 -- 57 FR 30608
At the request of the NTP, TSCA Section 8(d) reports on health effects of bis-(4-chlorophenyl) sulfone were provided to facilitate NTP's evaluation of this chemical. 80-07-9
Notice Draft Report: A Cross-Species Scaling Factor for Carcinogen Risk Assessment Based on Equivalence of mg/kg 3/4/day The EPA, FDA, and CPSC are asking for public comments on a draft report: A Cross-Species Scaling Factor for Carcinogen Risk Assessment Based on Equivalence of mg/kg/3/4/day.

June 05, 1992 -- 57 FR 24152
Data from NCI/NTP bioassays were used to develop the report.
Notice Ethylene Bisdithiocarbamates: Notice of Intent to Cancel; Conclusion of Special Review The EPA concludes the Special Review and risk/benefit analysis of EBDCs and announces the intent to cancel registrations and to deny applications for registration for all pesticide products containing EBDCs as an active ingredient unless the registrations/applications comply with the terms and conditions of registration set forth in this Notice. The Agency has determined that use will result in unreasonable adverse effects to humans or the environment.

March 02, 1992 -- 57 FR 7484
Data from the NTP bioassay on ethylene thiourea (ETU) were used by the EPA (TR-388) 96-45-7
Proposed Rule Aryl Phosphate Base Stocks; Proposed Test Rule Including Reporting and Record-keeping Requirements EPA proposes that manufacturers, importers and processors of chemical substances in the category of aryl phosphate base stocks be required, under section 4 of the Toxic Substances Control Act to conduct testing.

January 17, 1992 -- 57 FR 2138
Reproductive toxicity was demonstrated in the continuous breeding protocol in Swiss mice (1988). The EPA will examine the results of the NTP 2-year bioassay on TCP before deciding whether further oncogenicity testing on any other aryl phosphate is needed. (TR-433) 1330-78-5

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Food and Drug Administration (FDA)

Notice Type Title Summary of Notice NTP Information Cited CASRN
Final Rule Indirect Food Additives: Paper and Paperboard Components The FDA is amending the food additive regulations to provide for the safe use of ethyl acrylate in the manufacture of paper and paperboard intended for use in contact with food.

August 07, 1992 -- 57 FR 34865
The FDA used data from TR-259 on ethyl acrylate to estimate the upper-bound limit of lifetime human risk from exposure. 140-88-5
Final Rule Indirect Food Additives: Polymers The FDA is amending the food additive regulations to provide for the safe use of polyestercarbonate resin.

February 03, 1992 -- 57 FR 3938
Residual amounts of methylene chloride have been found in the additive. The FDA estimated the worst-case exposure to methylene chloride from the use of polyestercarbonate resin food-contact articles to be less than 15 micrograms per person per day. The FDA used data from TR-306 to estimate the upper-bound limit of lifetime human risk exposure to methylene chloride. 75-09-2

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Occupational Safety and Health Administration (OSHA)

Notice Type Title Summary of Notice NTP Information Cited CASRN
Final Rule Occupational Exposure to Cadmium OSHA publishes a new standard for occupational exposure to cadmium.

September 14, 1992 -- 57 FR 42102
Clear evidence of carcinogenicity of cadmium in animals was based on NTP's definition of clear evidence of carcinogenicity from the Report of the NTP Ad Hoc Panel on Chemical Carcinogenesis Testing and Evaluation.
Proposed Rule Air Contaminants Health Effects of Substances to be Regulated

June 12, 1992 -- 57 FR 26042
OSHA used data from several NTP studies. (TR-363) (TR-228) (TR-263) (TR-382) (TR-273) (TR-311) (TR-362) (TR-217) (TR-267) (TR-314) (TR-349) (TR-251) (TR-376) 74-96-4
75-35-4
78-87-5
98-01-1
79-01-6
127-18-4
106-87-6
96-18-4
117-81-7
75-05-8
75-56-9
80-62-6
87-86-5
26471-62-5
106-92-3
Proposed Rule Occupational Exposure to Methylene Chloride Notice of informal public hearings concerning OSHA's proposal to modify the existing provisions for controlling employee exposure to methylene chloride.

June 09, 1992 -- 57 FR 24438
OSHA based its preliminary estimate of human cancer risk on the NTP mouse study. (TR-306) 75-09-2

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