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Regulatory Actions for Year 2000

Year Agency Title CASRN
2000 OEHHA
Chemicals Listed Effective December 22, 2000 as Known to the State of California to Cause Cancer or Reproductive Toxicity: Bromoethane, and 4 others

The Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency is adding five chemicals to the list of chemicals known to the State to cause cancer or reproductive toxicity for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65). The chemicals are listed effective December 22, 2000. Bromoethane and isoxaflutole are listed pursuant to an administrative listing mechanism provided under Proposition 65, based upon a formal identification by an authoritative body that the chemicals cause cancer.

NTP Information Cited
National Toxicology Program (NTP, 1989). Toxicology and Carcinogenesis Studies of Bromoethane (Ethyl Bromide) (CAS No. 74-96-4) in F344/N Rats and B6C3F1 Mice (Inhalation Studies). NTP Technical Report Series No. 363 NTIS Publication No. 90-2818.

  • Type: Notice
  • December 22, 2000
  • Proposition 65
74-96-4
2000 FDA
Vinclozolin; Pesticide Tolerances

The FDA is amending the food additive regulations to provide for the safe use of hydrogenated butadiene/acrylonitrile copolymers intended for contact with food in repeated use applications. Although the additive itself has not been shown to cause cancer, it has been found to contain residual amounts of acrylonitrile and butadiene, carcinogenic impurities resulting from the manufacture of the additive.

NTP Information Cited
The FDA used data from the NTP Carcinogenicity Study of 1,3-Butadiene, (TR-434), to estimate the upper-bound limit of lifetime human risk from exposure resulting from the use of the additive. And based on its estimates of worst case exposure, the FDA concluded that there is reasonable certainty that no harm from exposure to butadiene would result from the proposed use of the additive.

  • Type: Final Rule
  • November 15, 2000
  • 65 FR 68888
106-99-0
2000 OSHA
Occupational Exposure to 4,4'Methylenedianiline (MDA)

OSHA is promulgating new standards regulating exposure to MDA.

NTP Information Cited
The Committee determined that the tumors found in the NTP study did not result from exposure to MDA. (TR-248)

  • Type: Final Rule
  • August 10, 2000
  • 57 FR 35630
13552-44-8
2000 EPA
Vinclozolin; Pesticide Tolerances

The EPA has established tolerances for combined residues of vinclozolin and its metabolites containing the 3,5-dichloroaniline moiety in or on specific raw agricultural commodities.

NTP Information Cited
The EPA used data from the NTP's p-Chloroaniline bioassay (TR-351) to help assess the carcinogenicity for structurally related chloroanilines.

  • Type: Final Rule
  • July 18, 2000
  • 65 FR 44453
20265-96-7
2000 OEHHA
Chemicals Listed Effective June 2, 2000 as Known to the State to Cause Cancer: Chloroprene, Cobalt sulfate heptahydrate, and Fenoxycarb

The Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency is adding three chemicals to the list of chemicals known to the State to cause cancer for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65). The chemicals are listed effective June 2, 2000 pursuant to an administrative listing mechanism provided under Proposition 65, based upon a formal identification by an authoritative body that the chemical causes cancer.

NTP Information Cited
National Toxicology Program (NTP, 1998a). Toxicology and Carcinogenesis Studies of Chloroprene (CAS No. 126-99-8) in F344/N Rats and B6C3F1 Mice (Inhalation Studies). Board Draft. NTP Technical Report Series No. 467 NTIS Publication No. 98-3957.

  • Type: Notice
  • June 22, 2000
  • Proposition 65
126-99-8
2000 OEHHA
Chemicals Listed Effective June 2, 2000 as Known to the State to Cause Cancer: Chloroprene, Cobalt sulfate heptahydrate, and Fenoxycarb

The Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency is adding three chemicals to the list of chemicals known to the State to cause cancer for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65). The chemicals are listed effective June 2, 2000 pursuant to an administrative listing mechanism provided under Proposition 65, based upon a formal identification by an authoritative body that the chemical causes cancer.

NTP Information Cited
National Toxicology Program (NTP, 1996). Toxicology and Carcinogenesis Studies of Isobutyl Nitrite (CAS No.542-56-3) in F344/N Rats and B6C3F1 Mice (Inhalation Studies). NTP Technical Report Series No. 448.

  • Type: Notice
  • June 22, 2000
  • Proposition 65
10026-24-1
2000 EPA
Diflubenzuron; Pesticide Tolerances

The EPA has received a pesticide petition for establishing a tolerance for residues of diflubenzuron in or on the raw agricultural commodity rangeland grass at 6.0 ppm. P-Chloroaniline (PCA) is a metabolite of diflubenzuron.

NTP Information Cited
Information from the NTP bioassay of p-Chloroaniline Hydrochloride, TR-351, was used to determine that the dietary risk from diflubenzuron-derived PCA is below EPA's level of concern.

  • Type: Notice
  • April 05, 2000
  • 65 FR 17872
20265-96-7
2000 OSHA
Air Contaminants

OSHA notice providing index to Jan. 19, 1989 final rule and list of references relied upon for health effects evaluations in rule.

NTP Information Cited
NTP references cited include TR-306, TR-228, TR-263, TR-273, ;TR-311, TR-259, TR-251.

  • Type: Final Rule
  • March 28, 2000
  • 54 FR 12792
78-87-5
127-18-4
140-88-5
26471-62-5
75-09-2 75-35-4
79-01-6
2000 EPA
Notice of Filing a Pesticide Petition to Establish a Tolerance for Certain Pesticide Chemicals in or on Food.

The FDA is amending the food additive regulations to provide for the safe use of ethylene-norbornene copolymers as articles or components of articles in contact with dry food. Although the additive itself has not been shown to cause cancer, it has been found to contain minute amounts of benzene, a carcinogenic impurity resulting from the manufacture of the additive.

NTP Information Cited
The FDA used data from the NTP Carcinogenicity Study of Benzene (TR-289), to estimate the upper-bound limit of lifetime human risk from exposure resulting from the use of the additive. And based on its estimates of worst case exposure, the FDA concluded that there is reasonable certainty that no harm from exposure to benzene would result from the proposed use of the additive.

  • Type: Final Rule
  • January 21, 2000
  • 65 FR 3384
71-43-2
2000 EPA
1,3-Dichloropropene: Proposed Determination to Terminate Special Review

The EPA proposed to terminate the Special Review of 1,3-Dichloropropene (1,3-D). The EPA has determined that the benefits associated with the continued use of 1,3-D under the recently revised terms and conditions of 1,3-D's reregistration outweigh the risks.

NTP Information Cited
The EPA classified 1,3-D as a probable, human carcinogen based on the review of data from carcinogenicity studies including the NTP Toxicology and Carcinogenesis Studies of Telone II (TR-269).

  • Type: Final Rule
  • January 12, 2000
  • 65 FR 1869
542-75-6