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Regulatory Actions for Year 2007


Agency for Toxic Substances and Disease Registry (ATSDR)

Notice Type Title Summary of Notice NTP Information Cited CASRN
Notice Intent To Develop Two Interaction Profiles This notice announces the intent of ATSDR to develop two interaction profiles.

July 03, 2007 -- 72 FR 36456
Where such information is not available or under development, ATSDR shall, in cooperation with the National Toxicology Program, initiate a program of research to determine these health effects.

California Office of Environmental Health Hazard Assessment (OEHHA)

Notice Type Title Summary of Notice NTP Information Cited CASRN
Notice Final Public Health Goal for Water Soluble Polychlorinated Biphenyls (PCBs) Expected to be Found in Drinking Water This Public Health Goal (PHG) technical support document provides information on health effects from Water Soluble Polychlorinated Biphenyls Expected to be Found in Drinking Water. PHGs are developed for chemical contaminants based on the best available toxicological data in the scientific literature. These documents and the analyses contained in them provide estimates of the levels of contaminants in drinking water that would pose no significant health risk to individuals consuming the water on a daily basis over a lifetime.

October 05, 2007 -- Public Health Goals
NTP (2000). Ninth Annual Report on Carcinogens.
Notice Chemical Listed Effective September 28, 2007 as Known to the State of California to Cause Cancer: anthraquinone (CAS No. 84-65-1) The Office of Environmental Health Hazard Assessment (OEHHA) within the California Environmental Protection Agency is adding anthraquinone (CAS No. 84-65-1) to the list of chemicals known to the state to cause cancer for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Health and Safety Code section 25249.5 et seq., commonly known as Proposition 65). The listing of anthraquinone is effective September 28, 2007. Anthraquinone (CAS No. 84-65-1) is being listed as a chemical known to the State of California to cause cancer. The listing of this chemical is based on formal identification by an authoritative body (i.e., the National Toxicology Program (NTP)), that the chemical causes cancer. The criteria used by OEHHA for the listing of chemicals under the authoritative bodies mechanism can be found in Title 22, Cal. Code of Regs., section 12306. Toxicological endpoint: cancer

September 28, 2007 -- Proposition 65
National Toxicology Program (NTP, 2005). Toxicology and Carcinogenesis Studies of Anthraquinone (CAS No. 84-65-1) in F344/N Rats and B6C3F1 Mice (Feed Studies). NTP Technical Report Series No. 494. NIH Publication No. 05-3953. U.S. Department of Health and Human Services, Public Health Service, National Institutes of Health, NTP, Research Triangle Park, NC. Also listed in the 11th Report on Carcinogens (2004) as reasonably anticipated to be a human carcinogen. 84-65-1
Notice Announcement of Publication of the Final Public Health Goal for Glyphosate in Drinking Water The Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency announces the publication of the final Public Health Goals (PHGs) for glyphosate, which is an update of the PHG published in 1997.

June 29, 2007 -- Public Health Goal
NTP (1992). NTP Technical Report on Toxicity Studies of Glyphosate (CAS No. 1071-83-6) Administered In Dosed Feed To F344/N Rats And B6C3F1 Mice. TOX-16. 1071-83-6
Notice Chemical Listed Effective April 20, 2007 as Known to the State of California to Cause Reproductive Toxicity: di-isodecyl phthalate (DIDP) The Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency is adding di-isodecyl phthalate (DIDP) (CAS No. 68515-49-1 and 26761-40-0) to the list of chemicals known to the state to cause reproductive toxicity for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Health and Safety Code section 25249.5 et seq., commonly known as Proposition 65). The listing of di-isodecyl phthalate (DIDP) is effective April 20, 2007.

April 20, 2007 -- Proposition 65
National Toxicology Program Center for the Evaluation of Risks to Human Reproduction (NTP-CERHR, 2003d). NTP-CERHR Monograph on the Potential Human Reproductive and Developmental Effects of Di-Isodecyl Phthalate (DIDP). NIH Publication No. 03-4485.
68515-49-1
26761-40-0

Environmental Protection Agency (EPA)

Notice Type Title Summary of Notice NTP Information Cited CASRN
Notice Draft Toxicological Review of Tetrahydrofuran: In Support of the Summary Information in the Integrated Risk Information System (IRIS) EPA is announcing that the Oak Ridge Institute of Science and Education (ORISE), under an Interagency agreement between the Department of Energy and EPA, will convene an independent panel of experts and organize and conduct an external peer-review workshop to review the external review draft document titled, "Toxicological Review of Tetrahydrofuran: In Support of Summary Information on the Integrated Risk Information System (IRIS" (NCEA-S-1620). The EPA also is announcing a public comment period for the draft document. EPA intends to consider comments and recommendations from the public and the expert panel meeting when EPA finalizes the draft document.

August 20, 2007 -- 72 FR 46483
The National Toxicology Program studies referenced in the Toxicological Review of Tetrahydrofuran are available by calling EPA's IRIS Hotline at 202-566-1676, by fax at 202-566-1749 or by e-mail at iris@epa.gov. 109-99-9
Notice Draft Toxicological Review of Bromobenzene: In Support of the Summary Information in the Integrated Risk Information System (IRIS) EPA is announcing that the Oak Ridge Institute of Science and Education (ORISE), under an Interagency agreement between the Department of Energy and EPA, will convene an independent panel of experts and organize and conduct an external peer-review workshop to review the external review draft document titled, "Toxicological Review of Bromobenzene: In Support of Summary Information on the Integrated Risk Information System (IRIS" (NCEA-C-1497). The EPA also is announcing a public comment period for the draft document. EPA intends to consider comments and recommendations from the public and the expert panel meeting when EPA finalizes the draft document.

June 14, 2007 -- 72 FR 32847
If you are requesting a paper copy, please provide your name, mailing address, and the document title. Copies are not available from ORISE. The National Toxicology Program studies referenced in the Toxicological Review of Bromobenzene are available by calling EPA's IRIS Hotline at (202) 566-1676, by fax at (202) 566-1749 or by e-mail at iris@epa.gov.
Final Rule Protection of Stratospheric Ozone: Listing of Substitutes for Ozone-Depleting Substances-n-Propyl Bromide in Solvent Cleaning The Environmental Protection Agency (EPA) determines that n-propyl bromide (nPB) is an acceptable substitute for methyl chloroform and chlorofluorocarbon (CFC)-113 in the solvent cleaning sector under the Significant New Alternatives Policy (SNAP) program under section 612 of the Clean Air Act. The SNAP program reviews alternatives to Class I and Class II ozone depleting substances and approves use of alternatives which do not present a substantially greater risk to public health and the environment than the substance they replace or than other available substitutes.

May 30, 2007 -- 72 FR 30142
These metabolic and subchronic inhalation studies conducted under the National Toxicology Program did not specifically examine for reproductive toxicity or nPB metabolism in target organs that control reproductive function. In summary, there is little available data about the metabolic activation or reactive metabolites responsible for reproductive toxicity in rodents. Similarly, for nPB, there is little information available about differences and similarities between rodents and humans.