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Regulatory Actions for Year 2009


Agency for Toxic Substances and Disease Registry (ATSDR)

Notice Type Title Summary of Notice NTP Information Cited CASRN
Notice Announcement of Final Priority Data Needs for Six Priority Hazardous Substances This notice announces the final priority data needs for six priority hazardous substances as part of the continuing development and implementation of the ATSDR Substance-Specific Applied Research Program (SSARP). This notice also serves as a continuous call for voluntary research proposals. A Tri-Agency Superfund Applied Research Committee (TASARC), comprised of scientists from ATSDR, NTP, EPA, FDA, and NIOSH, will review all proposals.

October 27, 2009 -- 74 FR 55240
The priority data needs for six substances are included in the ATSDR Priority List of Hazardous Substances (73 FR 12178, March 6, 2008). ATSDR initially announced these priority data needs in the Federal Register on December 28, 2007 (72 FR 73828). EPA, the National Institute of Environmental Health Sciences (NIEHS)/National Toxicology Program (NTP), the National Institute for Occupational Safety and Health (NIOSH), and the U.S. Food and Drug Administration/National Center for Toxicological Research (FDA/NCTR) reviewed the six priority data needs and accompanying documents. The mechanisms described in the "Implementation of Substance-Specific Applied Research Program" section of this Federal Register Notice address these data needs. NA
Notice Availability of Draft Toxicological Profile for Perfluoroalkyls This notice announces the availability of the draft toxicological profile for perfluoroalkyls, prepared by ATSDR, for review and comment.

July 23, 2009 -- 74 FR 36492
NTP in conjunction with ATSDR and EPA identified categories of possible data needs addressed in the draft profile. The NTP's carcinogenicity study of PFOA is mentioned in the section on ongoing studies. (PFOA) 335-67-1
Notice Announcement of Final Priority Data Needs for Two Priority Hazardous Substances This notice announces the final priority data needs for two priority hazardous substances as part of the continuing development and implementation of the ATSDR Substance-Specific Applied Research Program (SSARP). The notice also serves as a continuous call for voluntary research proposals.

January 09, 2009 -- 74 FR 900
A Tri-Agency Superfund Applied Research Committee (TASARC), comprised of scientists from ATSDR, the National Toxicology Program (NTP), and EPA will review all proposals. NA

California Office of Environmental Health Hazard Assessment (OEHHA)

Notice Type Title Summary of Notice NTP Information Cited CASRN
Proposed OEHHA Releases Draft (Pubic Health Goal) PHG for Hexavalent Chromium, announces workshop and opens comment period Draft public health goal for hexavalent chromium in drinking water. This draft document is a new risk assessment, culminating an extensive evaluation of oral toxicity of this chemical. A PHG of 0.06 ug/L or 0.06 parts per billion (ppb) is proposed for hexavalent chromium in drinking water, based on tumor incidence data from rodent cancer bioassays.

August 20, 2009 -- Public Health Goals
NTP (2008). NTP Technical Report on the Toxicology and Carcinogenesis Studies of Sodium Dichromate Dihydrate in F344/N Rats and B6C3F1 Mice. NTP TR 546. National Toxicology Program. 7789-12-0
Notice Announcement of Publication of The Final Public Health Goal For 1,2,3-Trichloropropane In Drinking Water Office of Environmental Health Hazard Assessment (OEHHA) within the California Environmental Protection Agency is announcing the availability of the final technical support document for the Public Health Goal (PHG) for the solvent 1,2,3-trichloropropane in drinking water. This document establishes a PHG for 1,2,3-trichloropropane of 0.0007 parts per billion, versus the current Notification Level of 0.005 ppb, set in 2005. The PHG is based on an updated cancer potency calculation.

August 20, 2009 -- Public Health Goals
NTP (1982). Carcinogenesis bioassay of 1,2-dibromo-3-chloropropane (CAS No. 96-12-8) in F344/N rats and B6C3F1 mice (inhalation studies). Technical Report Series No 206. NIH publication No. 82-1762. 

NTP (1993). Toxicology and carcinogenesis of 1,2,3-trichloropropane (CAS No. 96-18-4) in F344/N Rats and B6C3F1 Mice (gavage studies). Technical Report Series No 384. NIH publication No. 94-2839. 

NTP (2004). 1,2,3-Trichloropropane, Report on Carcinogens, Eleventh Edition
96-18-4
Proposed Announcement of First Public Comment Period and Workshop for the Draft Technical Support Document on Proposed Public Health Goal for Antimony in Drinking Water Public Health Goal (PHG) of 0.0007 mg/L or 0.7 parts per billion (ppb) is proposed for antimony in drinking water, based on data from use of antimonials in medical practice. In 1997, the Office of Environmental Health Hazard Assessment (OEHHA) developed a PHG for antimony of 20 ppb in drinking water, based on extrapolation from effect levels in rats.

July 23, 2009 -- Public Health Goals
NTP (1992). Technical report on the toxicity studies of antimony potassium tartrate in F344/N rats and B6C3F1 mice (drinking water and intraperitoneal injection studies). NTP Tox 11. 1309-64-4
Notice Announcement of Publication of the Final Public Health Goal for Tri­chloro­ethyl­ene in Drinking Water OEHHA within the California Environmental Protection Agency is announcing the availability of the final technical support document for the Public Health Goal (PHG) for the solvent tri­chloro­ethyl­ene in drinking water. This document increases the PHG for tri­chloro­ethyl­ene to 1.7 parts per billion, versus 0.8 ppb in the original PHG published in 1999. The PHG is based on the same cancer endpoint with an updated potency calculation.

July 09, 2009 -- Public Health Goals
NTP (1983). Technical report on the carcinogenesis studies of tri­chloro­ethyl­ene (without epichlorohydrin) (CAS No.79-01-6) in F344/N rats and B6C3Fl mice (gavage studies): Draft report. Publ. No. 83-1799. 

NTP (1988). Toxicology and carcinogenesis studies of tri­chloro­ethyl­ene (CAS No. 79-01-6) in four strains of rats (ACI, August, Marshall, Osborne-Mendel) (gavage studies). Tech Report Series No.273. NIH Publ. No. 88-2525. 
NTP (1990). Carcinogenesis studies of tri­chloro­ethyl­ene (without epichlorohydrin) (CAS No. 79-01-6) in F344/N rats and B6C3F1 mice (gavage studies). Tech Report Series No. 243.  
NTP (1997). Time course autoimmunity study of tri­chloro­ethyl­ene (CAS No. 79-01-6) in female brown Norway rats. Tech Rep Series No. IMM96007.
79-01-6
Proposed Announcement of First Public Comment Period and Workshop Draft Technical Support Document on Proposed Public Health Goals for Trihalomethanes in Drinking Water A proposed PHG health risk assessment for each of the four major trihalomethanes (THMs) found in drinking water as a consequence of the chlorination disinfection process, and proposes four individual Public Health Goals (PHGs). The four THMs are chloroform (CHCl3), bromoform (CHBr3), bromodichloromethane (CHBrCl2, or BDCM), and dibromochloromethane (CHBr2Cl, or DBCM). The proposed PHG for chloroform is 0.001 milligram per liter (mg/L) or 1 microgram per liter (μg/L) or 1 part per billion (ppb); for bromoform 5 μg/L; for BDCM 0.4 μg/L; and for DBCM 0.7 μg/L.

June 19, 2009 -- Public Health Goals
NTP (1985). Toxicology and carcinogenesis studies of chlorodibromomethane (CAS No. 124-48-1) in F344/N rats and B6C3F1 mice (gavage studies). NTP Technical Report Series No. 282.

NTP (1987). Toxicology and carcinogenesis studies of bromodichloromethane (CAS No. 75-27-4) in F344/N rats and B6C3F1 mice (gavage studies). NTP Technical Report Series No. 321.

NTP (1988). Chloroform reproduction and fertility assessment in CD-1 mice when administered by gavage. Report by Environmental Health Research and Testing, Inc., Lexington, Kentucky, to National Toxicology Program, NTP-89-018. NTIS PB89-148639.

NTP (1989a). Toxicology and carcinogenesis studies of tribromomethane (bromoform) (CAS No. 75-25-2) in F344/N rats and B6C3F1 mice (gavage studies). NTP Technical Report Series No. 350.

NTP (1989b). Bromoform: reproduction and fertility assessment in Swiss CD-1 mice when administered by gavage. Report no. NTP-89-068.

NTP (1994). Comparative toxicology studies of corn oil, safflower oil, and tricaprylin (CAS Nos. 8001-30-7, 8001-23-8, and 538-23-8) in male F344/N rats as vehicles for gavage. NTP Technical Report Series No. 426.

NTP (1996). Final report on the short term reproductive and developmental toxicity of chlorodibromomethane (CAS No. 124-48-1) administered in drinking water to Sprague-Dawley rats. Report by R.O.W. Sciences, Inc., Gaithersburg, MD. Pub No. NTIS/PB97-111728.

NTP (1998). Final Report on the short-term reproductive and developmental toxicity of bromodichloromethane (CAS No. 75-27-4) administered in drinking water to Sprague-Dawley rats. Pub no. NTIS/PB99-111262.

NTP (2004). Bromodichloromethane and Chloroform. In: 11th Report on Carcinogens.

67-66-33
75-25-2
75-27-4
124-48-1
Notice Announcement of Publication of The Final Public Health Goals for Lead, Oxamyl and Pentachlorophenol In Drinking Water A revised Public Health Goal (PHG) of 0.3 parts per billion (ppb) is hereby established for pentachlorophenol (PCP) in drinking water, based on carcinogenicity. The earlier PHG for PCP of 0.4 ppb, developed in 1997, is based on the same rodent carcinogenicity data and a cancer potency value identical to that used in this revised PHG.

April 24, 2009 -- Public Health Goals
NTP (1989). Toxicology and carcinogenesis studies of two pentachlorophenol technical-grade mixtures in B6C3F1 mice. NTP TR 349, NIH No. 88-2804.

NTP (1999). Toxicology and carcinogenesis studies of pentachlorophenol in F344/N rats. NTP TR 483, NIH No. 99-3973.

87-86-5
Notice Announcement of Publication of The Final Public Health Goals for Lead, Oxamyl and Pentachlorophenol In Drinking Water The purpose of this document is to review and evaluate the new data since 1997 regarding the toxicity of lead that are relevant to the estimation of a public health-protective level in drinking water, and establish any necessary changes in the previous risk assessment based on the new findings. This document is centered on updating the earlier OEHHA assessments for drinking water (OEHHA, 1997a, 2007).

April 24, 2009 -- Public Health Goals
NTP (2005). Report on carcinogens. 11th edition.

Department of Transportation (DOT)

Notice Type Title Summary of Notice NTP Information Cited CASRN
Proposed Proposed Rulemaking To Establish Light-Duty Vehicle Greenhouse Gas Emission Standards and Corporate Average Fuel Economy Standards EPA and NHTSA are issuing this joint proposal to establish a National Program consisting of new standards for light-duty vehicles that will reduce greenhouse gas emissions and improve fuel economy. This joint proposed rulemaking is consistent with the National Fuel Efficiency Policy announced by President Obama on May 19, 2009, responding to the country’s critical need to address global climate change and to reduce oil consumption. EPA is proposing greenhouse gas emissions standards under the Clean Air Act, and NHTSA is proposing Corporate Average Fuel Economy standards under the Energy Policy and Conservation Act, as amended. These standards apply to passenger cars, light-duty trucks, and medium-duty passenger vehicles, covering model years 2012 through 2016, and represent a harmonized and consistent National Program. Under the National Program, automobile manufacturers would be able to build a single light-duty national fleet that satisfies all requirements under both programs while ensuring that consumers still have a full range of vehicle choices.

September 28, 2009 -- 74 FR 49553
The National Toxicology Program in its Report on Carcinogens has characterized many components of automobile and truck engines to be known or potential carcinogens. They are benzene, 1, 3-butadiene, acetaldehyde, and naphthalene.  (ROC) 71-43-2
106-99-0
75-07-0
91-20-3

Environmental Protection Agency (EPA)

Notice Type Title Summary of Notice NTP Information Cited CASRN
Proposed Public Availability of Identities of Inert Ingredients in Pesticides In response to two petitions seeking disclosure of selected inert ingredients on pesticide labels, based on hazard, EPA is initiating rulemaking to increase public availability of the identities of the inert ingredients in pesticide products. This action would assist consumers and users of pesticides in making informed decisions and reduce the presence of potentially hazardous ingredients in pesticides.

December 23, 2009 -- 74 FR 68215
Suggested hazard criteria, which could be used to identify potential carcinogenic substances to be listed in the ingredient statement, include (1) known or presumed human carcinogens and those classified as Group 1 or Group 2 by the International Agency for Research on Cancer (IARC); (2) evidence of carcinogenic activity by the National Toxicology Program (NTP) and/or the Environmental Protection Agency (EPA); and/or (3) a Category I Potential Carcinogen by the Occupational Safety and Health Administration (OSHA). NA
Notice Agency Information Collection Activities; Proposed Collection; Comment Request; Analysis of Archived Environmental Samples From the American Healthy Homes Survey (New); EPA ICR No. XXXX.XX, OMB Control No. 20XX–XXXX In compliance with the Paperwork Reduction Act (PRA) (44 U.S.C. 3501 et seq.), this document announces that EPA is planning to submit a request for a new Information Collection Request (ICR) to the Office of Management and Budget (OMB). Before submitting the ICR to OMB for review and approval, EPA is soliciting comments on specific aspects of the proposed information collection as described below.

November 03, 2009 -- 74 FR 56831

NTP Work Cited: Phthalates are used in the manufacture of a wide range of industrial and household consumer products to prolong durability and increase the flexibility of plastics and as chemical stabilizers for other materials. Animal data suggest a broad spectrum of potential health outcomes including developmental toxicity, endocrine disruption, and carcinogenicity. However, the characterization of human exposure to phthalates is limited and the National Toxicology Program’s Center for the Evaluation of the Risks to Human Reproduction has concluded that more data regarding the potential for human exposure are needed. 

OHAT (formerly CERHR) Evaluations and Workshops, see phthalates. (OHAT)

NA
Proposed Lead; Amendment to the Opt-out and Recordkeeping Provisions in the Renovation, Repair, and Painting Program EPA proposes several revisions to the Lead Renovation, Repair, and Painting Program (RRP) rule that published in the Federal Register on April 22, 2008. The rule establishes accreditation, training, certification, and recordkeeping requirements, as well as work practice standards on persons performing renovations for compensation in most pre-1978 housing and child-occupied facilities. In this document, EPA proposes eliminating the ‘‘opt-out’’ provision that currently exempts a renovation firm from the training and work practice requirements of the rule where the firm obtains a certification from the owner of a residence he or she occupies that no child under age 6 or pregnant women resides in the home and the home is not a child- occupied facility. EPA also proposes requiring renovation firms to provide a copy of the records demonstrating compliance with the training and work practice requirements of the RRP rule to the owner and, if different, the occupant of the building being renovated or the operator of the child-occupied facility.

October 28, 2009 -- 74 FR 55506
Lead exerts ‘‘a broad array of deleterious effects on multiple organ systems via widely diverse mechanisms of action’’. Health effects include impacts on heme biosynthesis and related functions, neurological development and function, reproduction and physical development, kidney function, cardiovascular function, and immune function. There is also some evidence of lead carcinogenicity, primarily from animal studies, together with limited human evidence of suggestive associations. (Lead) 7439-92-1
Proposed Proposed Rulemaking To Establish Light-Duty Vehicle Greenhouse Gas Emission Standards and Corporate Average Fuel Economy Standards EPA and NHTSA are issuing this joint proposal to establish a National Program consisting of new standards for light-duty vehicles that will reduce greenhouse gas emissions and improve fuel economy. This joint proposed rulemaking is consistent with the National Fuel Efficiency Policy announced by President Obama on May 19, 2009, responding to the country’s critical need to address global climate change and to reduce oil consumption. EPA is proposing greenhouse gas emissions standards under the Clean Air Act, and NHTSA is proposing Corporate Average Fuel Economy standards under the Energy Policy and Conservation Act, as amended. These standards apply to passenger cars, light-duty trucks, and medium-duty passenger vehicles, covering model years 2012 through 2016, and represent a harmonized and consistent National Program. Under the National Program, automobile manufacturers would be able to build a single light-duty national fleet that satisfies all requirements under both programs while ensuring that consumers still have a full range of vehicle choices.

September 28, 2009 -- 74 FR 49553
The National Toxicology Program in its Report on Carcinogens has characterized many components of automobile and truck engines to be known or potential carcinogens. They are benzene, 1, 3-butadiene, acetaldehyde, and naphthalene. (ROC) 71-43-2
106-99-0
75-07-0
91-20-3
Final Rule Amine Salts of Alkyl (C8-C24) Benzenesulfonic Acid (Dimethylaminopropylamine, Isopropylamine, Mono-, Di-, and Triethanolamine); Exemption from the Requirement of a Tolerance This regulation establishes an exemption from the requirement of a tolerance for residues of amine salts of alkyl (C8-C24) benzenesulfonic acid (dimethylaminopropylamine, isopropylamine, mono-, di-, and triethanolamine) when used as an inert ingredient in pesticide formulations applied to growing crops and applied to animals. The Joint Inerts Task Force, Cluster Support Team Number 8, submitted a petition to EPA under the Federal Food, Drug, and Cosmetic Act (FFDCA), requesting an exemption from the requirement of a tolerance. This regulation eliminates the need to establish a maximum permissible level for residues of amine salts of alkyl (C8-C24) benzenesulfonic acid (dimethyl aminopropylamine, isopropylamine, mono-, di, and triethanolamine).

August 05, 2009 -- 74 FR 38924
Subchronic (13-week) oral toxicity study in rats (NTP, 1992). (Diethanolamine) 111-42-2
Final Rule Residues of Silver in Foods from Food Contact Surface Sanitizing Solutions; Exemption from the Requirement of a Tolerance This regulation amends the exemption from the requirement of a tolerance for residues of silver (excludes silver salts) in or on all foods when applied or used in public eating places, dairy processing equipment, and food processing equipment. ETO H2O, Inc., submitted a petition to EPA under the Federal Food, Drug, and Cosmetic Act requesting to establish concentration limits for silver in end-use solutions eligible for tolerance exemption. The regulation being established will exempt all foods from the requirement of a tolerance for residues of silver resulting from contact with surfaces treated with solutions in which the end-use concentration of silver is not to exceed 50 parts per million (ppm).

June 10, 2009 -- 74 FR 27447
There are extensive data and analysis on silvers toxicity in the historical data/literature and the regulatory advisories established by other Federal Agencies, which do not indicate an increased susceptibility of children to the toxic effects of silver. A NTP developmental toxicity study concluded that the NOAEL recorded for developmental toxicity in rats receiving gavage doses of silver acetate was greater than 100 mg/ kg when the test material was administered on gestation days 6 through 19. No increase in susceptibility was apparent in this study. NA
Proposed Regulation of Fuels and Fuel Additives: Changes to Renewable Fuel Standard Program Under the Clean Air Act, as amended by Sections 201, 202, and 210 of the Energy Independence and Security Act of 2007, the Environmental Protection Agency is required to promulgate regulations implementing changes to the Renewable Fuel Standard program.

May 26, 2009 -- 74 FR 25053
Acetaldehyde is reasonably anticipated to be a human carcinogen by the U.S. DHHS in the 11th Report on Carcinogens. (Acetaldehyde) The U.S. Department of Health and Human Services (DHHS) has characterized benzene as a known human carcinogen. (Benzene) The U.S. DHHS has characterized 1,3-butadiene as a known human carcinogen. (1,3-Butadiene) The U.S. DHHS in the 11th Report on Carcinogens identified alcoholic beverages as a known human carcinogen (they have not evaluated the cancer risks specifically from exposure to ethanol), with evidence for cancer of the mouth, pharynx, larynx, esophagus, liver and breast. (Ethanol) The National Toxicology Program listed naphthalene as reasonably anticipated to be a human carcinogen in 2004 on the basis of bioassays reporting clear evidence of carcinogenicity in rats and some evidence of carcinogenicity in mice. (Naphthalene ) (ROC) 75-07-0
71-43-2
106-99-0
64-17-5
91-20-3

Food and Drug Administration (FDA)

Notice Type Title Summary of Notice NTP Information Cited CASRN
Notice Acrylamide in Food; Request for Comments and for Scientific Data and Information The Food and Drug Administration (FDA) is requesting comments and scientific data and information on acrylamide in food. Acrylamide is a chemical that can form in some foods during certain types of high-temperature cooking. FDA is seeking information on practices that manufacturers have used to reduce acrylamide in food and the reductions they have been able to achieve in acrylamide levels. FDA is considering issuing guidance for industry on reduction of acrylamide levels in food products.

August 26, 2009 -- 74 FR 43134
Under the sponsorship of the National Toxicology Program, FDAs National Center for Toxicological Research (NCTR) embarked in 2002 on a series of new toxicology assays for acrylamide. These studies were designed to address deficiencies in earlier carcinogenicity studies and to provide more reliable data on potential carcinogenic risk of acrylamide and other potential effects of acrylamide exposure. The work at NCTR includes long-term carcinogenicity bioassays of acrylamide and its metabolite glycidamide in mice and rats, as well as toxicokinetic, bioavailability, mutagenicity, and neurodevelopmental studies. NCTRs work also includes the development of a physiologically based pharmacokinetic model for acrylamide and glycidamide. (Acrylamide) (Glycidamide ) 79-06-1
5694-00-8

National Institute for Occupational Safety and Health (NIOSH)

Notice Type Title Summary of Notice NTP Information Cited CASRN
Notice Request for Information on 1-Bromopropane The National Institute for Occupational Safety and Health (NIOSH) of the Centers for Disease Control and Prevention (CDC) intends to evaluate the scientific data on the brominated organic solvent, 1-Bromopropane (1–BP, CAS # 106–94–5, also known as n-propyl bromide), and develop appropriate communication documents, such as a Current Intelligence Bulletin, Criteria Document and/or other informational products, and establish a Recommended Exposure Limit (REL) for 1–BP. NIOSH is requesting information on the following: (1) published and unpublished reports and findings from in vitro and in vivo toxicity studies with 1–BP, (2) information on possible health effects observed in workers exposed to 1–BP, (3) information on workplaces and products in which 1–BP can be found, (4) description of work tasks and scenarios with a potential for exposure to 1–BP, (5) workplace exposure data, and (6) information on control measures (e.g., engineering controls, work practices, personal protective equipment) that are being used in workplaces where potential exposures to 1–BP occur.

September 16, 2009 -- 74 FR 47593
The National Toxicology Program (NTP) estimated that approximately 8.2 million pounds (lbs) of 1–BP were used in the United States (U.S.) in 2002. Estimates of the number of workers exposed to 1–BP are unavailable due to limited exposure data and its relatively recent introduction into domestic commerce.  (1-Bromopropane 106-94-5

Occupational Safety and Health Administration (OSHA)

Notice Type Title Summary of Notice NTP Information Cited CASRN
Proposed Hazard Communication OSHA proposes to modify its existing Hazard Communication Standard (HCS) to conform with the United Nations’ (UN) Globally Harmonized System of Classification and Labeling of Chemicals (GHS). OSHA has preliminarily determined that the proposed modifications will improve the quality and consistency of information provided to employers and employees regarding chemical hazards and associated protective measures. The Agency anticipates this improved information will enhance the effectiveness of the HCS in ensuring that employees are apprised of the chemical hazards to which they may be exposed, and in reducing the incidence of chemical-related occupational illnesses and injuries.

September 30, 2009 -- 74 FR 50379
Since carcinogenicity is the most controversial and difficult health effect to address, OSHA considers chemicals found to be carcinogenic in the National Toxicology Program’s Report on Carcinogens, or in monographs published by the International Agency for Research on Cancer, to be carcinogens in addition to those regulated by OSHA as carcinogens.  (ROC) NA
Proposed Occupational Exposure to Diacetyl and Food Flavorings Containing Diacetyl OSHA is requesting data, information, and comment on issues related to occupational exposure to diacetyl and food flavorings containing diacetyl, including current employee exposures to diacetyl; the relationship between exposure to diacetyl and the development of adverse health effects; exposure assessment and monitoring methods; exposure control methods; employee training; medical surveillance for adverse health effects related to diacetyl exposure; and other pertinent subjects. In this notice, OSHA intends the term diacetyl and food flavorings containing diacetyl to encompass other constituents of food flavorings containing diacetyl. In addition to information on diacetyl, OSHA seeks information on acetoin, acetaldehyde, acetic acid, furfural, and other compounds present in food flavorings that may cause or contribute to flavoring-related lung disease. The Agency is also interested in and seeks information about diacetyl present in substances other than food flavorings (e.g., naturally occurring diacetyl or diacetyl in fragrances) as well as substitutes used in place of diacetyl (e.g., diacetyl trimer). The information received in response to this document will assist the Agency in developing a proposed standard addressing occupational exposure to diacetyl and food flavorings containing diacetyl.

January 21, 2009 -- 74 FR 3938
The National Toxicology Program has approved the nomination of BFV, diacetyl, and acetoin for longer term inhalation testing.  (Artificial Butter Flavoring Mixture) (2,3-Butanedione (Diacetyl)) (Acetoin) BUTTERFLAVMX
431-03-8
513-86-0