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Regulatory Actions for Years 2000 to 2009


Agency for Toxic Substances and Disease Registry (ATSDR)

Notice Type Title Summary of Notice NTP Information Cited CASRN
Notice Announcement of Final Priority Data Needs for Six Priority Hazardous Substances This notice announces the final priority data needs for six priority hazardous substances as part of the continuing development and implementation of the ATSDR Substance-Specific Applied Research Program (SSARP). This notice also serves as a continuous call for voluntary research proposals. A Tri-Agency Superfund Applied Research Committee (TASARC), comprised of scientists from ATSDR, NTP, EPA, FDA, and NIOSH, will review all proposals.

October 27, 2009 -- 74 FR 55240
The priority data needs for six substances are included in the ATSDR Priority List of Hazardous Substances (73 FR 12178, March 6, 2008). ATSDR initially announced these priority data needs in the Federal Register on December 28, 2007 (72 FR 73828). EPA, the National Institute of Environmental Health Sciences (NIEHS)/National Toxicology Program (NTP), the National Institute for Occupational Safety and Health (NIOSH), and the U.S. Food and Drug Administration/National Center for Toxicological Research (FDA/NCTR) reviewed the six priority data needs and accompanying documents. The mechanisms described in the "Implementation of Substance-Specific Applied Research Program" section of this Federal Register Notice address these data needs. NA
Notice Availability of Draft Toxicological Profile for Perfluoroalkyls This notice announces the availability of the draft toxicological profile for perfluoroalkyls, prepared by ATSDR, for review and comment.

July 23, 2009 -- 74 FR 36492
NTP in conjunction with ATSDR and EPA identified categories of possible data needs addressed in the draft profile. The NTP's carcinogenicity study of PFOA is mentioned in the section on ongoing studies. (PFOA) 335-67-1
Notice Announcement of Final Priority Data Needs for Two Priority Hazardous Substances This notice announces the final priority data needs for two priority hazardous substances as part of the continuing development and implementation of the ATSDR Substance-Specific Applied Research Program (SSARP). The notice also serves as a continuous call for voluntary research proposals.

January 09, 2009 -- 74 FR 900
A Tri-Agency Superfund Applied Research Committee (TASARC), comprised of scientists from ATSDR, the National Toxicology Program (NTP), and EPA will review all proposals. NA
Notice Availability of Draft Toxicological Profiles The Comprehensive Environmental Response, Compensation, and Liability Act of 1980 (CERCLA), as amended by the Superfund Amendments and Reauthorization Act of 1986 (SARA), Section 104(i)(3) [42 U.S.C. 9604(i)(3)], directs the Administrator of ATSDR to prepare toxicological profiles of priority hazardous substances and to revise and publish each updated toxicological profile as necessary. This notice announces the availability of the 22nd set of toxicological profiles, which consists of four updated drafts prepared by ATSDR for review and comment. The toxicological profiles for formaldehyde and perfluoroalkyls are on a modified schedule pending additional review.

November 06, 2008 -- 73 FR 66047
The profiles must also include a determination of whether adequate information on the health effects of each substance is available or in the process of development. When adequate information is not available, ATSDR, in cooperation with the National Toxicology Program (NTP), is required to ensure the initiation of research to determine these health effects. NA
Notice Intent To Develop Two Interaction Profiles This notice announces the intent of ATSDR to develop two interaction profiles.

July 03, 2007 -- 72 FR 36456
Where such information is not available or under development, ATSDR shall, in cooperation with the National Toxicology Program, initiate a program of research to determine these health effects.
Notice Availability of Draft Toxicological Profiles The Comprehensive Environmental Response, Compensation, and Liability Act of 1980 (CERCLA), as amended by the Superfund Amendments and Reauthorization Act of 1986 (SARA), Section 104(i)(3) [42 U.S.C. 9604(i)(3)] directs the Administrator of ATSDR to prepare toxicological profiles of priority hazardous substances and to revise and publish each updated toxicological profile as necessary. This notice announces the availability of the 20th set of toxicological profiles, which consists of one new draft and six updated drafts, prepared by ATSDR for review and comment.

October 18, 2006 -- 71 FR 61479
The profiles must also include a determination of whether adequate information on the health effects of each substance is available or in the process of development. When adequate information is not available, ATSDR, in cooperation with the National Toxicology Program (NTP), is required to assure the initiation of research to determine these health effects.
Notice Identification of Priority Data Needs for Two Priority Hazardous Substances Request for public comments on the identification of priority data needs for two priority hazardous substances, and an ongoing call for voluntary research proposals.

September 08, 2006 -- 71 FR 53102
A Tri-Agency Superfund Applied Research Committee (TASARC) comprised of scientists from ATSDR, the National Toxicology Program (NTP), and EPA, will review all proposals.

California Office of Environmental Health Hazard Assessment (OEHHA)

Notice Type Title Summary of Notice NTP Information Cited CASRN
Proposed OEHHA Releases Draft (Pubic Health Goal) PHG for Hexavalent Chromium, announces workshop and opens comment period Draft public health goal for hexavalent chromium in drinking water. This draft document is a new risk assessment, culminating an extensive evaluation of oral toxicity of this chemical. A PHG of 0.06 ug/L or 0.06 parts per billion (ppb) is proposed for hexavalent chromium in drinking water, based on tumor incidence data from rodent cancer bioassays.

August 20, 2009 -- Public Health Goals
NTP (2008). NTP Technical Report on the Toxicology and Carcinogenesis Studies of Sodium Dichromate Dihydrate in F344/N Rats and B6C3F1 Mice. NTP TR 546. National Toxicology Program. 7789-12-0
Notice Announcement of Publication of The Final Public Health Goal For 1,2,3-Trichloropropane In Drinking Water Office of Environmental Health Hazard Assessment (OEHHA) within the California Environmental Protection Agency is announcing the availability of the final technical support document for the Public Health Goal (PHG) for the solvent 1,2,3-trichloropropane in drinking water. This document establishes a PHG for 1,2,3-trichloropropane of 0.0007 parts per billion, versus the current Notification Level of 0.005 ppb, set in 2005. The PHG is based on an updated cancer potency calculation.

August 20, 2009 -- Public Health Goals
NTP (1982). Carcinogenesis bioassay of 1,2-dibromo-3-chloropropane (CAS No. 96-12-8) in F344/N rats and B6C3F1 mice (inhalation studies). Technical Report Series No 206. NIH publication No. 82-1762. 

NTP (1993). Toxicology and carcinogenesis of 1,2,3-trichloropropane (CAS No. 96-18-4) in F344/N Rats and B6C3F1 Mice (gavage studies). Technical Report Series No 384. NIH publication No. 94-2839. 

NTP (2004). 1,2,3-Trichloropropane, Report on Carcinogens, Eleventh Edition
96-18-4
Proposed Announcement of First Public Comment Period and Workshop for the Draft Technical Support Document on Proposed Public Health Goal for Antimony in Drinking Water Public Health Goal (PHG) of 0.0007 mg/L or 0.7 parts per billion (ppb) is proposed for antimony in drinking water, based on data from use of antimonials in medical practice. In 1997, the Office of Environmental Health Hazard Assessment (OEHHA) developed a PHG for antimony of 20 ppb in drinking water, based on extrapolation from effect levels in rats.

July 23, 2009 -- Public Health Goals
NTP (1992). Technical report on the toxicity studies of antimony potassium tartrate in F344/N rats and B6C3F1 mice (drinking water and intraperitoneal injection studies). NTP Tox 11. 1309-64-4
Notice Announcement of Publication of the Final Public Health Goal for Tri­chloro­ethyl­ene in Drinking Water OEHHA within the California Environmental Protection Agency is announcing the availability of the final technical support document for the Public Health Goal (PHG) for the solvent tri­chloro­ethyl­ene in drinking water. This document increases the PHG for tri­chloro­ethyl­ene to 1.7 parts per billion, versus 0.8 ppb in the original PHG published in 1999. The PHG is based on the same cancer endpoint with an updated potency calculation.

July 09, 2009 -- Public Health Goals
NTP (1983). Technical report on the carcinogenesis studies of tri­chloro­ethyl­ene (without epichlorohydrin) (CAS No.79-01-6) in F344/N rats and B6C3Fl mice (gavage studies): Draft report. Publ. No. 83-1799. 

NTP (1988). Toxicology and carcinogenesis studies of tri­chloro­ethyl­ene (CAS No. 79-01-6) in four strains of rats (ACI, August, Marshall, Osborne-Mendel) (gavage studies). Tech Report Series No.273. NIH Publ. No. 88-2525. 
NTP (1990). Carcinogenesis studies of tri­chloro­ethyl­ene (without epichlorohydrin) (CAS No. 79-01-6) in F344/N rats and B6C3F1 mice (gavage studies). Tech Report Series No. 243.  
NTP (1997). Time course autoimmunity study of tri­chloro­ethyl­ene (CAS No. 79-01-6) in female brown Norway rats. Tech Rep Series No. IMM96007.
79-01-6
Proposed Announcement of First Public Comment Period and Workshop Draft Technical Support Document on Proposed Public Health Goals for Trihalomethanes in Drinking Water A proposed PHG health risk assessment for each of the four major trihalomethanes (THMs) found in drinking water as a consequence of the chlorination disinfection process, and proposes four individual Public Health Goals (PHGs). The four THMs are chloroform (CHCl3), bromoform (CHBr3), bromodichloromethane (CHBrCl2, or BDCM), and dibromochloromethane (CHBr2Cl, or DBCM). The proposed PHG for chloroform is 0.001 milligram per liter (mg/L) or 1 microgram per liter (μg/L) or 1 part per billion (ppb); for bromoform 5 μg/L; for BDCM 0.4 μg/L; and for DBCM 0.7 μg/L.

June 19, 2009 -- Public Health Goals
NTP (1985). Toxicology and carcinogenesis studies of chlorodibromomethane (CAS No. 124-48-1) in F344/N rats and B6C3F1 mice (gavage studies). NTP Technical Report Series No. 282.

NTP (1987). Toxicology and carcinogenesis studies of bromodichloromethane (CAS No. 75-27-4) in F344/N rats and B6C3F1 mice (gavage studies). NTP Technical Report Series No. 321.

NTP (1988). Chloroform reproduction and fertility assessment in CD-1 mice when administered by gavage. Report by Environmental Health Research and Testing, Inc., Lexington, Kentucky, to National Toxicology Program, NTP-89-018. NTIS PB89-148639.

NTP (1989a). Toxicology and carcinogenesis studies of tribromomethane (bromoform) (CAS No. 75-25-2) in F344/N rats and B6C3F1 mice (gavage studies). NTP Technical Report Series No. 350.

NTP (1989b). Bromoform: reproduction and fertility assessment in Swiss CD-1 mice when administered by gavage. Report no. NTP-89-068.

NTP (1994). Comparative toxicology studies of corn oil, safflower oil, and tricaprylin (CAS Nos. 8001-30-7, 8001-23-8, and 538-23-8) in male F344/N rats as vehicles for gavage. NTP Technical Report Series No. 426.

NTP (1996). Final report on the short term reproductive and developmental toxicity of chlorodibromomethane (CAS No. 124-48-1) administered in drinking water to Sprague-Dawley rats. Report by R.O.W. Sciences, Inc., Gaithersburg, MD. Pub No. NTIS/PB97-111728.

NTP (1998). Final Report on the short-term reproductive and developmental toxicity of bromodichloromethane (CAS No. 75-27-4) administered in drinking water to Sprague-Dawley rats. Pub no. NTIS/PB99-111262.

NTP (2004). Bromodichloromethane and Chloroform. In: 11th Report on Carcinogens.

67-66-33
75-25-2
75-27-4
124-48-1
Notice Announcement of Publication of The Final Public Health Goals for Lead, Oxamyl and Pentachlorophenol In Drinking Water A revised Public Health Goal (PHG) of 0.3 parts per billion (ppb) is hereby established for pentachlorophenol (PCP) in drinking water, based on carcinogenicity. The earlier PHG for PCP of 0.4 ppb, developed in 1997, is based on the same rodent carcinogenicity data and a cancer potency value identical to that used in this revised PHG.

April 24, 2009 -- Public Health Goals
NTP (1989). Toxicology and carcinogenesis studies of two pentachlorophenol technical-grade mixtures in B6C3F1 mice. NTP TR 349, NIH No. 88-2804.

NTP (1999). Toxicology and carcinogenesis studies of pentachlorophenol in F344/N rats. NTP TR 483, NIH No. 99-3973.

87-86-5
Notice Announcement of Publication of The Final Public Health Goals for Lead, Oxamyl and Pentachlorophenol In Drinking Water The purpose of this document is to review and evaluate the new data since 1997 regarding the toxicity of lead that are relevant to the estimation of a public health-protective level in drinking water, and establish any necessary changes in the previous risk assessment based on the new findings. This document is centered on updating the earlier OEHHA assessments for drinking water (OEHHA, 1997a, 2007).

April 24, 2009 -- Public Health Goals
NTP (2005). Report on carcinogens. 11th edition.
Notice Chemical Listed Effective June 17, 2008 as Known to the State of California to Cause Cancer, Dibromoacetic acid (CAS No. 631-64-1) The Office of Environmental Health Hazard Assessment (OEHHA) within the California Environmental Protection Agency is adding dibromoacetic acid (CAS No. 631-64-1) to the list of chemicals known to the state to cause cancer for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Health and Safety Code section 25249.5 et seq., commonly known as Proposition 65). The listing of dibromoacetic acid is effective June 17, 2008. Toxicological endpoints: Reproductive Toxicity and Cancer

June 13, 2008 -- Proposition 65
National Toxicology Program (NTP, 2007). Toxicology and Carcinogenesis Studies of Dibromoacetic Acid (CAS No. 631-64-1) in F344/N Rats and B6C3F1 Mice (Drinking Water Studies). NTP Technical Report Series No. 537. NIH Publication No. 07-4475 631-64-1
Notice Final Public Health Goal for Copper in Drinking Water This Public Health Goal (PHG) technical support document provides information on health effects from copper in drinking water. PHGs are developed for chemical contaminants based on the best available toxicological data in the scientific literature. These documents and the analyses contained in them provide estimates of the levels of contaminants in drinking water that would pose no significant health risk to individuals consuming the water on a daily basis over a lifetime.

February 08, 2008 -- Public Health Goals
NTP (1993) Technical Report on Toxicity Studies of Cupric Sulfate (CAS No. 7758-99-8) Administered in Drinking Water and Feed to F344/N Rats and B6C3FX Mice. NIH Publication 93-3352; Research Triangle Park, NC 27709 7758-99-8
Notice Final Public Health Goal for Water Soluble Polychlorinated Biphenyls (PCBs) Expected to be Found in Drinking Water This Public Health Goal (PHG) technical support document provides information on health effects from Water Soluble Polychlorinated Biphenyls Expected to be Found in Drinking Water. PHGs are developed for chemical contaminants based on the best available toxicological data in the scientific literature. These documents and the analyses contained in them provide estimates of the levels of contaminants in drinking water that would pose no significant health risk to individuals consuming the water on a daily basis over a lifetime.

October 05, 2007 -- Public Health Goals
NTP (2000). Ninth Annual Report on Carcinogens.
Notice Chemical Listed Effective September 28, 2007 as Known to the State of California to Cause Cancer: anthraquinone (CAS No. 84-65-1) The Office of Environmental Health Hazard Assessment (OEHHA) within the California Environmental Protection Agency is adding anthraquinone (CAS No. 84-65-1) to the list of chemicals known to the state to cause cancer for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Health and Safety Code section 25249.5 et seq., commonly known as Proposition 65). The listing of anthraquinone is effective September 28, 2007. Anthraquinone (CAS No. 84-65-1) is being listed as a chemical known to the State of California to cause cancer. The listing of this chemical is based on formal identification by an authoritative body (i.e., the National Toxicology Program (NTP)), that the chemical causes cancer. The criteria used by OEHHA for the listing of chemicals under the authoritative bodies mechanism can be found in Title 22, Cal. Code of Regs., section 12306. Toxicological endpoint: cancer

September 28, 2007 -- Proposition 65
National Toxicology Program (NTP, 2005). Toxicology and Carcinogenesis Studies of Anthraquinone (CAS No. 84-65-1) in F344/N Rats and B6C3F1 Mice (Feed Studies). NTP Technical Report Series No. 494. NIH Publication No. 05-3953. U.S. Department of Health and Human Services, Public Health Service, National Institutes of Health, NTP, Research Triangle Park, NC. Also listed in the 11th Report on Carcinogens (2004) as reasonably anticipated to be a human carcinogen. 84-65-1
Notice Announcement of Publication of the Final Public Health Goal for Glyphosate in Drinking Water The Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency announces the publication of the final Public Health Goals (PHGs) for glyphosate, which is an update of the PHG published in 1997.

June 29, 2007 -- Public Health Goal
NTP (1992). NTP Technical Report on Toxicity Studies of Glyphosate (CAS No. 1071-83-6) Administered In Dosed Feed To F344/N Rats And B6C3F1 Mice. TOX-16. 1071-83-6
Notice Chemical Listed Effective April 20, 2007 as Known to the State of California to Cause Reproductive Toxicity: di-isodecyl phthalate (DIDP) The Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency is adding di-isodecyl phthalate (DIDP) (CAS No. 68515-49-1 and 26761-40-0) to the list of chemicals known to the state to cause reproductive toxicity for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Health and Safety Code section 25249.5 et seq., commonly known as Proposition 65). The listing of di-isodecyl phthalate (DIDP) is effective April 20, 2007.

April 20, 2007 -- Proposition 65
National Toxicology Program Center for the Evaluation of Risks to Human Reproduction (NTP-CERHR, 2003d). NTP-CERHR Monograph on the Potential Human Reproductive and Developmental Effects of Di-Isodecyl Phthalate (DIDP). NIH Publication No. 03-4485.
68515-49-1
26761-40-0
Notice Final Public Health Goal for N-Nitrosodimethylamine and Cadmium in Drinking Water The Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency announces the publication of the final Public Health Goals (PHGs) for N-nitrosodimethylamine and cadmium.

December 22, 2006 -- Proposition 65
NTP (2000). 9th Report on Carcinogens.
Notice Chemicals Delisted Effective December 8, 2006 from the List of Chemicals Known to the State of California to Cause Cancer, isosafrole, 5-nitro-o-anisidine, tris(aziridinyl)-p-benzoquinone The Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency is removing isosafrole [CAS No. 120-58-1], 5-nitro-o-anisidine [CAS No. 99-59-2], and tris(aziridinyl)-p-benzoquinone (triaziquone) [CAS No. 68-76-8] from the list of chemicals known to the State to cause cancer for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65). The delisting of the three chemicals is effective December 8, 2006. 5-Nitro-o-anisidine was removed from the NTP Sixth Annual Report on Carcinogens as a substance reasonably anticipated to be a human carcinogen in 1991, when NTP concluded there was insufficient evidence of carcinogenicity.

December 08, 2006 -- Proposition 65
Report on Carcinogens, Eleventh Edition (2004); Appendix B; National Toxicology Program, U.S. Department of Health and Human Services, Research Triangle Park, NC 99-59-2
Notice Announcement of Publication of the Final Technical Support Documents for the Public Health Goal and Responses to Comments for Six Chemicals in Drinking Water In accordance with Health and Safety Code Section 116293 (SB1822, Sher, Statutes of 2002), the Office of Environmental Health Hazard Assessment (OEHHA) hereby publishes the final Public Health Goal (PHG) for cis/trans-1,2-dichloroethylene, 1,1,1-trichloroethane, 1,1,2-trichloroethane, radium-226 and 228, strontium-90, and tritium in drinking water. OEHHA has completed technical support documents that provide the scientific basis for the PHGs.

March 06, 2006 -- Proposition 65
NTP (2002). Toxicity Studies of trans-1,2-Dichloroethylene (CAS No. 156-60-5) Administered in Microcapsules in Feed to F344/N Rats and B6C3F1 Mice. TOX-55. 156-60-5
Notice Announcement of Publication of the Final Technical Support Documents for the Public Health Goal and Responses to Comments for Six Chemicals in Drinking Water In accordance with Health and Safety Code Section 116293 (SB1822, Sher, Statutes of 2002), the Office of Environmental Health Hazard Assessment (OEHHA) hereby publishes the final Public Health Goal (PHG) for cis/trans-1,2-dichloroethylene, 1,1,1-trichloroethane, 1,1,2-trichloroethane, radium-226 and 228, strontium-90, and tritium in drinking water. OEHHA has completed technical support documents that provide the scientific basis for the PHGs.

March 06, 2006 -- Proposition 65
NTP (1988). Developmental toxicity evaluation of 1,1,1-trichloroethane (CAS No. 7l-55-6) administered to CD rats. Final report part 2. TO151 and TO179.

NTP (1996). Technical report on renal toxicity studies of selected halogenated ethanes administered by gavage to F344/N rats. Toxicity Report Series. TOX-45

NTP (2000). Technical report on the toxicity studies of 1,1,1-trichloroethane (CAS No. 71-55-6) administered in microcapsules in feed to F344/N rats and B6C3F1 mice. TOX-41
71-55-6
Notice Chemicals Listed Effective December 2, 2005 as Known to the State of California to Cause Reproductive Toxicity: butyl benzyl phthalate (BBP) (CAS No. 85 68-7), di-n-butyl phthalate (DBP) (CAS No. 84-74-2), and di-n-hexyl phthalate (DnHP) (CAS No. 84-75-3) The Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency is adding butyl benzyl phthalate (BBP) (CAS No. 85 68-7), di-n-butyl phthalate (DBP) (CAS No. 84-74-2), and di-n-hexyl phthalate (DnHP) (CAS No. 84-75-3) to the list of chemicals known to the state to cause reproductive toxicity for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Health and Safety Code section 25249.5 et seq., commonly known as Proposition 65). The listing of the three phthalates is effective December 2, 2005 Toxicological endpoint: cancer. Toxicological endpoints: Developmental toxicity, Female reproductive toxicity, and Male reproductive toxicity

December 02, 2005 -- Proposition 65
National Toxicology Program. Center for the Evaluation of Risks to Human Reproduction (NTP-CERHR, 2003b). NTP-CERHR Monograph on the Potential Human Reproductive and Developmental Effects of Di-n-Butyl Phthalate (DBP). NIH Publication No. 03-4486. 84-74-2
Notice Chemicals Listed Effective December 2, 2005 as Known to the State of California to Cause Reproductive Toxicity: butyl benzyl phthalate (BBP) (CAS No. 85 68-7), di-n-butyl phthalate (DBP) (CAS No. 84-74-2), and di-n-hexyl phthalate (DnHP) (CAS No. 84-75-3) The Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency is adding butyl benzyl phthalate (BBP) (CAS No. 85 68-7), di-n-butyl phthalate (DBP) (CAS No. 84-74-2), and di-n-hexyl phthalate (DnHP) (CAS No. 84-75-3) to the list of chemicals known to the state to cause reproductive toxicity for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Health and Safety Code section 25249.5 et seq., commonly known as Proposition 65). The listing of the three phthalates is effective December 2, 2005 Toxicological endpoint: cancer. Toxicological endpoints: female reproductive toxicity and male reproductive toxicity

December 02, 2005 -- Proposition 65
National Toxicology Program. Center for the Evaluation of Risks to Human Reproduction (NTP-CERHR, 2003c). NTP-CERHR Monograph on the Potential Human Reproductive and Developmental Effects of Di-n-Hexyl Phthalate (DnHP). NIH Publication No. 03-4489. 84-75-3
Notice Chemicals Listed Effective December 2, 2005 as Known to the State of California to Cause Reproductive Toxicity: butyl benzyl phthalate (BBP) (CAS No. 85 68-7), di-n-butyl phthalate (DBP) (CAS No. 84-74-2), and di-n-hexyl phthalate (DnHP) (CAS No. 84-75-3) The Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency is adding butyl benzyl phthalate (BBP) (CAS No. 85 68-7), di-n-butyl phthalate (DBP) (CAS No. 84-74-2), and di-n-hexyl phthalate (DnHP) (CAS No. 84-75-3) to the list of chemicals known to the state to cause reproductive toxicity for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Health and Safety Code section 25249.5 et seq., commonly known as Proposition 65). The listing of the three phthalates is effective December 2, 2005 Toxicological endpoint: cancer. Toxicological endpoints: Developmental toxicity

December 02, 2005 -- Proposition 65
National Toxicology Program. Center for the Evaluation of Risks to Human Reproduction (NTP-CERHR, 2003a). NTP-CERHR Monograph on the Potential Human Reproductive and Developmental Effects of Butyl Benzyl Phthalate (BBP). NIH Publication No. 03-4487. 85-68-7
Notice Chemicals Listed Effective August 19, 2005 as Known to the State of California to Cause Cancer: estrogens, steroidal The Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency is adding estrogens, steroidal to the list of chemicals known to the state to cause cancer for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Health and Safety Code section 25249.5, Proposition 65). The listing of estrogens, steroidal is effective August 19, 2005.

August 19, 2005 -- Proposition 65
National Toxicology Program (NTP, 2002). Report on Carcinogens, Tenth Edition. Carcinogen Profiles. U.S. Department of Health and Human Services, Public Health Service. National Institute of Environmental Health Sciences, Research Triangle Park, NC. Steroidal Estrogens (as a class)
Notice Chemicals Listed Effective May 27, 2005 and May 31, 2005 as known to the State of California to Cause Cancer or Reproductive Toxicity The Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency is adding 2-bromopropane (2-BP) (CAS No. 75-26-3)...to the list of chemicals known to the state to cause cancer or reproductive toxicity for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Health and Safety Code section 25249.5, Proposition 65). The listing of... 2-bromopropane (2-BP) is effective May 31, 2005. Toxicological endpoint: Female reproductive and male reproductive toxicity

May 31, 2005 -- Proposition 65
National Toxicology Program - Center for the Evaluation of Risks to Human Reproduction (NTP-CERHR, 2003). NTP-CERHR Monograph on the Potential Human Reproductive and Developmental Effects of 2-Bromopropane . NIH Publication No. 04-4480. U.S. Department of Health and Human Services, Public Health Service, National Institutes of Health, NTP, Research Triangle Park, NC. 75-26-3
Notice Chemicals Listed Effective May 20, 2005 as Known to the State of California to Cause Cancer: Cobalt sulfate, Diazoaminobenzene The Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency is adding cobalt sulfate (CAS No. 10124-43-3) and diazoaminobenzene (CAS No. 136-35-6) to the list of chemicals known to the state to cause cancer for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Health and Safety Code section 25249.5, Proposition 65). The listing of cobalt sulfate and diazoaminobenzene is effective May 20, 2005. Toxicological Endpoint: cancer

May 20, 2005 -- Proposition 65
National Toxicology Program (NTP, 2004). Report on Carcinogens, Eleventh Edition. Carcinogen Profiles. U.S. Department of Health and Human Services, Public Health Service. National Institute of Environmental Health Sciences, Research Triangle Park, NC. 10124-43-3
Notice Chemicals Listed Effective May 20, 2005 as Known to the State of California to Cause Cancer: Cobalt sulfate, Diazoaminobenzene The Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency is adding cobalt sulfate (CAS No. 10124-43-3) and diazoaminobenzene (CAS No. 136-35-6) to the list of chemicals known to the state to cause cancer for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Health and Safety Code section 25249.5, Proposition 65). The listing of cobalt sulfate and diazoaminobenzene is effective May 20, 2005. Toxicological Endpoint: cancer

May 20, 2005 -- Proposition 65
NTP concluded that diazoaminobenzene (DAAB) is reasonably anticipated to be a human carcinogen based on evidence from studies in animals and with human tissue demonstrating that DAAB is metabolized to benzene, a known human carcinogen, and on evidence that DAAB causes genetic damage. 
National Toxicology Program (NTP, 2004). Report on Carcinogens, Eleventh Edition. Carcinogen Profiles. U.S. Department of Health and Human Services, Public Health Service. National Institute of Environmental Health Sciences, Research Triangle Park, NC.
136-35-6
Notice Chemical Listed Effective February 11, 2005 as Known to the State of California to Cause Cancer: Vanadium Pentoxide The Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency is adding vanadium pentoxide (orthorhombic crystalline form) to the list of chemicals known to the state to cause cancer for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Health and Safety Code section 25249.5 et seq., Proposition 65). The listing of the chemical is effective February 11, 2005. Toxicological Endpoint: Cancer

February 11, 2005 -- Proposition 65
National Toxicology Program (NTP, 2002). Toxicology and Carcinogensis Studies of Vanadium Pentoxide (CAS No. 1314-62-1) in F344/N Rats and B6C3F1 Mice (Inhalation). NTP Technical Report Series No. 507. NIH Publication No. 03-4441. U.S. Department of Health and Human Services, Public Health Service, National Institutes of Health, NTP, Research Triangle Park, NC. 1314-63-1
Notice Chemical Listed Effective December 7, 2004 as known to the State of California to Cause Reproductive Toxicity: 1-Bromopropane (1-BP) The Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency is adding 1-bromopropane (1-BP) to the list of chemicals known to the state to cause reproductive toxicity for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Health and Safety Code section 25249.5 et seq., Proposition 65). The listing of the chemical is effective December 7, 2004. Toxicological Endpoint: Developmental, female reproductive and male reproductive toxicity

December 07, 2004 -- Proposition 65
NTP Center for the Evaluation of Risks to Human Reproduction (NTP-CERHR 2003). NTP-CERHR Monograph on the Potential Human Reproductive and Developmental Effects of 1-Bromopropane (CAS No. 106-94-5). NIH Publication No. 04-4479 106-94-5
Notice Chemical Listed Effective December 3, 2004 as known to the State of California to Cause Cancer: Riddelliine The Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency is adding riddelliine to the list of chemicals known to the state to cause cancer for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Health and Safety Code section 25249.5, Proposition 65). The listing of riddelliine is effective December 3, 2004. Toxicological Endpoint: Cancer

December 03, 2004 -- Proposition 65
Health and Safety Code section 25249.8(a) requires that certain substances identified by the International Agency for Research on Cancer (IARC) or the National Toxicology Program (NTP), as described in Labor Code sections 6382(b)(1) and (d), be included on the Proposition 65 list. 
Riddelline is a current candidate substance under review for the NTP Twelfth Edition Report on Carcinogens. 
National Toxicology Program (NTP, 2003). Toxicology and Carcinogensis Studies of Riddelliine (CAS No. 23246-96-0) in F344/N Rats and B6C3F1 Mice (Gavage Studies). NTP Technical Report Series No. 508. NIH Publication No. 03-4442.
23246-96-0
Notice Chemicals Listed Effective July 9, 2004 as Known to the State of California to Cause Cancer: aristolochic acids and herbal remedies containing plant species of the genus Aristolochia The Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency is adding aristolochic acids and herbal remedies containing plant species of the genus Aristolochia to the list of chemicals known to the state to cause cancer for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Health and Safety Code section 25249.5, Proposition 65). The listing of "aristolochic acids and herbal remedies containing plant species of the genus Aristolochia is effective July 9, 2004. Toxicological Endpoint: Cancer

July 09, 2004 -- Proposition 65
Health and Safety Code section 25249.8(a) requires that certain substances identified by the International Agency for Research on Cancer (IARC) or the National Toxicology Program (NTP), as described in Labor Code sections 6382(b)(1) and (d), be included on the Proposition 65 list. 
Aristolochic acid related exposures are current candidate substances under review for the NTP Twelfth Edition, Report on Carcinogens.
Aristolochia
Notice Chemicals Listed Effective June 11, 2004 as Known to the State of California to Cause Cancer: propylene glycol mono-t-butyl ether The Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency is adding 3,3'-dimethoxybenzidine-(DMOB)based dyes metabolized to 3,3'-dimethoxybenzidine, 3,3'-dimethylbenzidine- (DMB)based dyes metabolized to 3,3'-dimethylbenzidine, ethylbenzene, propylene glycol mono-t-butyl ether, and thiouracil to the list of chemicals known to the state to cause cancer for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Health and Safety Code section 25249.5 et seq., Proposition 65). The listing of these chemicals is effective June 11, 2004. Toxicological Endpoint: Cancer

June 11, 2004 -- Proposition 65
National Toxicology Program (NTP, 2004). Toxicology and Carcinogenesis Studies of Propylene Glycol Mono-t-Butyl Ether (CAS No. 57018-52-7) In F344/N Rats and B6C3F1 Mice and a Toxicology Study of Propylene Glycol Mono-t-Butyl Ether In Male NBR Rats (Inhalation Studies). NTP Technical Report Series No. 515. NIH Publication No. 04-4449 57018-52-7
Notice Chemicals Listed Effective June 11, 2004 as Known to the State of California to Cause Cancer: 3,3'-dimethylbenzidine (DMB)-based dyes metabolized to 3,3'-dimethylbenzidine The Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency is adding 3,3'-dimethoxybenzidine-(DMOB)based dyes metabolized to 3,3'-dimethoxybenzidine, 3,3'-dimethylbenzidine- (DMB)based dyes metabolized to 3,3'-dimethylbenzidine, ethylbenzene, propylene glycol mono-t-butyl ether, and thiouracil to the list of chemicals known to the state to cause cancer for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Health and Safety Code section 25249.5 et seq., Proposition 65). The listing of these chemicals is effective June 11, 2004. Toxicological Endpoint: Cancer

June 11, 2004 -- Proposition 65
National Toxicology Program (NTP, 2002). Tenth Report on Carcinogens. Carcinogen Profiles. U.S. Department of Health and Human Services, Public Health Service. National Institute of Environmental Health Sciences, Research Triangle Park, NC. DMB based dyes
Notice Chemicals Listed Effective June 11, 2004 as Known to the State of California to Cause Cancer: 3,3'-dimethoxybenzidine-based dyes metabolized to 3,3'-dimethoxybenzidine The Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency is adding 3,3'-dimethoxybenzidine-based dyes metabolized to 3,3'-dimethoxybenzidine, 3,3'-dimethylbenzidine-based dyes metabolized to 3,3'-dimethylbenzidine, ethylbenzene, propylene glycol mono-t-butyl ether, and thiouracil to the list of chemicals known to the state to cause cancer for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Health and Safety Code section 25249.5 et seq., Proposition 65). The listing of these chemicals is effective June 11, 2004. Toxicological Endpoint: Cancer

June 11, 2004 -- Proposition 65
National Toxicology Program (NTP, 2002). Tenth Report on Carcinogens. Carcinogen Profiles. U.S. Department of Health and Human Services, Public Health Service. National Institute of Environmental Health Sciences, Research Triangle Park, NC. DMOB based dyes
Notice Chemical Listed Effective May 7, 2004 as known to the State of California to Cause Cancer: Nickel Compounds The Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency is adding nickel compounds to the list of chemicals known to the state to cause cancer for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Health and Safety Code section 25249.5, Proposition 65). The listing of nickel compounds is effective May 7, 2004. Toxicological Endpoint: Cancer

May 07, 2004 -- Proposition 65
NTP released its Tenth Report on Carcinogens in 2002 in which it included nickel compounds on the list of substances as known to be human carcinogens. 
National Toxicology Program (NTP, 2002). Report on Carcinogens, Tenth Edition. Carcinogen Profiles. U.S. Department of Health and Human Services, Public Health Service. National Institute of Environmental Health Sciences, Research Triangle Park, NC.
Nickel compounds
Notice Announcement of Publication of the Final Public Health Goal for Arsenic in Drinking Water The Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency announces the publication of the final Public Health Goal (PHG) for arsenic.

April 23, 2004 -- Public Health Goals
NTP (1989). Toxicology and Carcinogenesis Studies of Roxarsone (CAS No. 121-19-7) in F344/N Rats and B6C3F1 Mice (Feed Studies). TR-345. 121-19-7
Notice Chemical Listed Effective November 14, 2003 as Known to the State of California to Cause Cancer: Fumonisin B1 The Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency is adding fumonisin B1 to the list of chemicals known to the State to cause cancer for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65). The listing of fumonisin B1 is effective November 14, 2003 Toxicological Endpoint: Cancer

November 14, 2003 -- Proposition 65
National Toxicology Program (NTP, 2001). Toxicology and Carcinogenesis Studies of Fumonisin B1 (CAS No. 116355-83-0) in F344/N Rats and B6C3F1 Mice (Feed Studies). NTP Technical Report Series No. 496, NIH Publication No. 01-3955 116355-83-0
Notice Announcement of Publication of the Final Technical Support Documents for Public Health Goals for 11 Chemicals in Drinking Water The Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency announces the availability of the final technical support documents for a Public Health Goal (PHG) for each of the following eleven (11) chemicals in drinking water.

September 26, 2003 -- Public Health Goals
NTP (1983). Lifetime carcinogenesis studies of amosite asbestos (CAS No. 12172-73-5) in Syrian golden hamsters (feed studies). Tech report series No. 249.

NTP (1985). Toxicology and carcinogenesis studies of chrysotile asbestos (CAS No. 12001-29-5) in F344/N rats (feed studies ). Tech report series No. 295.

NTP (1988). Toxicology and carcinogenesis studies of crocidolite asbestos (CAS No. 12001-28-4) in F344/N rats (feed studies). Tech report series No. 280.

NTP (1990a). Lifetime carcinogenesis studies of chrysotile asbestos (CAS No. 12001- 29-5) in Syrian golden hamsters (feed studies). Tech report series No. 246.

NTP (1990b). Toxicology and carcinogenesis series of amosite asbestos in F344/N rats. Tech report series No. 279.

NTP (1990c). Technical Report on the toxicology and carcinogenesis studies of tremolite (CAS No. 14567-73-8) in Fischer 344 rats (feed studies). Tech report series No. 277.

NTP (2000). Asbestos. CAS No. 1332-21-4. Ninth Report on Carcinogens

1332-21-4
Notice Announcement of Publication of the Final Technical Support Documents for Public Health Goals for 11 Chemicals in Drinking Water The Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency announces the availability of the final technical support documents for a Public Health Goal (PHG) for each of the following eleven (11) chemicals in drinking water.

September 26, 2003 -- Public Health Goals
NTP (1982). Carcinogenesis bioassay of di(2-ethylhexyl)adipate (CAS No. 103-23-1) in F344 Rats and B6C3F1 Mice (Feed Study). Technical Report, Series No. 212. 103-23-1
Notice Announcement of Publication of the Final Technical Support Documents for Public Health Goals for 11 Chemicals in Drinking Water The Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency announces the availability of the final technical support documents for a Public Health Goal (PHG) for each of the following eleven (11) chemicals in drinking water.

September 26, 2003 -- Public Health Goals
NTP (1985). Technical Report on the Toxicology and Carcinogenesis Studies of Chlorobenzene (CAS No. 108-90-7) in F344/N Rats and B6C3F1 Mice (Gavage Studies). NTP TR 261. 108-90-7
Notice Announcement of Publication of the Final Technical Support Documents for Public Health Goals for 11 Chemicals in Drinking Water The Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency announces the availability of the final technical support documents for a Public Health Goal (PHG) for each of the following eleven (11) chemicals in drinking water.

September 26, 2003 -- Public Health Goals
NTP (1982). Carcinogenesis bioassay of 1,2-dibromoethane in F344 rats and B6C3F1 mice (inhalation study). Technical report No. 210. 106-93-4
Notice Announcement of Publication of the Final Technical Support Documents for Public Health Goals for 11 Chemicals in Drinking Water The Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency announces the availability of the final technical support documents for a Public Health Goal (PHG) for each of the following eleven (11) chemicals in drinking water. (barium)

September 26, 2003 -- Public Health Goals
NTP (1994). Technical report on the toxicology and carcinogenesis studies of barium chloride dihydrate (CAS No. 10326-27-9) in F344/N rats and B6C3F1 mice. TR-432 10326-27-9
Notice Chemical Listed Effective March 14, 2003 as Known to the State of California to Cause Cancer: Strong Inorganic Acid Mists Containing Sulfuric Acid The Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency is adding strong inorganic acid mists containing sulfuric acid to the list of chemicals known to the State to cause cancer for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65). The listing of strong inorganic acid mists containing sulfuric acid is effective March 14, 2003. Toxicological Endpoint: Cancer

March 14, 2003 -- Proposition 65
National Toxicology Program (NTP, 2000). Report on Carcinogens, Ninth Edition: Carcinogen Profiles. U.S. Department of Health and Human Services, Public Health Service, NTP, Research Triangle Park, NC. 7664-93-9 (Mists containing)
Notice Chemical Listed Effective May 17, 2002 as Known to the State of California to Cause Cancer: Pyridine The Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency is adding pyridine to the list of chemicals known to the State to cause cancer for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65). The listing of pyridine is effective May 17, 2002. Toxicological Endpoint: Cancer

May 17, 2002 -- Proposition 65
National Toxicology Program (NTP, 2000). Toxicology and Carcinogenesis Studies of Pyridine (CAS No. 110-86-1) in F344/N Rats, Wistar Rats and B6C3F1 Mice (Drinking Water Studies). NTP Technical Report Series No. 470. NIH Publication No. 97-3960. 110-86-1
Notice Chemical Listed Effective April 19, 2002 as Known to the State of California to Cause Cancer: Naphthalene The Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency is adding naphthalene to the list of chemicals known to the State to cause cancer for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65). The listing of naphthalene is effective April 19, 2002. Toxicological Endpoint: Cancer

April 19, 2002 -- Proposition 65
National Toxicology Program (NTP, 2000). Toxicology and Carcinogenesis Studies of Naphthalene (CAS No. 91-20-3) in F344/N Rats (Inhalation Studies). NTP Technical Report Series No. 500. NIH Publication No. 01-4434. 91-20-3
Notice Chemical Listed Effective November 16, 2001 as Known to the State of California to Cause Cancer: Methyleugenol The Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency is adding the chemical methyleugenol to the list of chemicals known to the State to cause cancer for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65). The chemical is listed effective November 16, 2001. Toxicological Endpoint: Cancer

November 16, 2001 -- Proposition 65
National Toxicology Program (NTP, 2000a). Toxicology and Carcinogenesis Studies ofMethyleugenol (CAS No. 93-15-2) in F344/N Rats and B6C3F1 Mice (Gavage Studies). NTP Technical Report Series No. 491 NIH Publication No. 00-3950. 93-15-2
Notice Chemicals Delisted Effective April 6, 2001 as Known to the State to Cause Cancer The California Environmental Protection Agency's Office of Environmental Health Hazard Assessment (OEHHA) is the lead agency for the implementation of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65). As the lead agency, OEHHA is removing saccharin from the list of chemicals known to the state to cause cancer, for purposes of Proposition 65. Saccharin [CAS No. 81-07-2] was originally added to the Proposition 65 list on October 1, 1989. This chemical was added to the Proposition 65 list as a result of the issuance of a judicial decision enforcing Labor Code Section 6382(b)(1) and (d) which are incorporated by reference as Proposition 65 listing provisions pursuant to Health and Safety Code Section 25249.8(b). Labor Code Section 6382(b)(1) requires inclusion of substances listed as human or animal carcinogens by the International Agency for Research on Cancer (IARC). Labor Code Section 6382(d) requires the inclusion of chemicals identified as carcinogens or potential carcinogens by IARC or the National Toxicology Program (NTP). Saccharin was identified by IARC and NTP as causing cancer.

April 06, 2001 -- Proposition 65
In 2000, NTP released its Ninth Report on Carcinogens in which it delisted saccharin [CAS No. 81 07-2] from the list of substances reasonably anticipated to be a human carcinogen. 
National Toxicology Program (NTP, 2000). Report on Carcinogens, Ninth Edition: Carcinogen Profiles. U.S. Department of Health and Human Services, Public Health Service, NTP, Research Triangle Park, NC.
81-07-2
Notice Chemicals Listed Effective February 23, 2001 as Known to the State to Cause Cancer or Reproductive Toxicity: 13 chemicals The Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency is adding thirteen chemicals to the list of chemicals known to the State to cause cancer or reproductive toxicity for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65). The chemicals are listed effective February 27, 2001. Ethoprop, indium phosphide, lynestrenol, norethynodrel, and propachlor are listed pursuant to an administrative listing mechanism provided under Proposition 65, based upon a formal identification by an authoritative body that the chemicals cause cancer.

February 23, 2001 -- Proposition 65
National Toxicology Program (NTP, 2000a). Toxicology and Carcinogenesis Studies of Indium Phosphide (CAS No. 22398-80-7) in F344/N Rats and B6C3F1 Mice (Inhalation Studies). Board Draft. NTP Technical Report Series No. 499. NTIS Publication No. 00-4433. 22398-80-7
Notice Chemicals Listed Effective December 22, 2000 as Known to the State of California to Cause Cancer or Reproductive Toxicity: Bromoethane, and 4 others The Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency is adding five chemicals to the list of chemicals known to the State to cause cancer or reproductive toxicity for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65). The chemicals are listed effective December 22, 2000. Bromoethane and isoxaflutole are listed pursuant to an administrative listing mechanism provided under Proposition 65, based upon a formal identification by an authoritative body that the chemicals cause cancer.

December 22, 2000 -- Proposition 65
National Toxicology Program (NTP, 1989). Toxicology and Carcinogenesis Studies of Bromoethane (Ethyl Bromide) (CAS No. 74-96-4) in F344/N Rats and B6C3F1 Mice (Inhalation Studies). NTP Technical Report Series No. 363 NTIS Publication No. 90-2818. 74-96-4
Notice Chemicals Listed Effective June 2, 2000 as Known to the State to Cause Cancer: Chloroprene, Cobalt sulfate heptahydrate, and Fenoxycarb The Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency is adding three chemicals to the list of chemicals known to the State to cause cancer for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65). The chemicals are listed effective June 2, 2000 pursuant to an administrative listing mechanism provided under Proposition 65, based upon a formal identification by an authoritative body that the chemical causes cancer.

June 22, 2000 -- Proposition 65
National Toxicology Program (NTP, 1998a). Toxicology and Carcinogenesis Studies of Chloroprene (CAS No. 126-99-8) in F344/N Rats and B6C3F1 Mice (Inhalation Studies). Board Draft. NTP Technical Report Series No. 467 NTIS Publication No. 98-3957. 126-99-8
Notice Chemicals Listed Effective June 2, 2000 as Known to the State to Cause Cancer: Chloroprene, Cobalt sulfate heptahydrate, and Fenoxycarb The Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency is adding three chemicals to the list of chemicals known to the State to cause cancer for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65). The chemicals are listed effective June 2, 2000 pursuant to an administrative listing mechanism provided under Proposition 65, based upon a formal identification by an authoritative body that the chemical causes cancer.

June 22, 2000 -- Proposition 65
National Toxicology Program (NTP, 1996). Toxicology and Carcinogenesis Studies of Isobutyl Nitrite (CAS No.542-56-3) in F344/N Rats and B6C3F1 Mice (Inhalation Studies). NTP Technical Report Series No. 448. 10026-24-1

Consumer Product Safety Commission (CPSC)

Notice Type Title Summary of Notice NTP Information Cited CASRN
Notice Standard for the Flammability of Residential Upholstered Furniture The United States Consumer Product Safety Commission (Commission or CPSC) is proposing flammability standards for residential upholstered furniture under the Flammable Fabrics Act (FFA). The proposal would establish performance requirements and certification and labeling requirements for upholstered furniture. Manufacturers of upholstered furniture would choose one of two possible methods of compliance: They could use cover materials that are sufficiently smolder resistant to meet a cigarette ignition performance test; or they could place fire barriers that meet smoldering and open flame resistance tests between the cover fabric and interior filling materials. Manufacturers of upholstered furniture would be required to certify compliance with the standard and to comply with certain recordkeeping requirements as specified in the proposal.

March 04, 2008 -- 73 FR 11702
At the request of the staff, the National Toxicology Program (NTP) of the Department of Health and Human Services has undertaken a review of several FRs that could be used to meet CPSC flammability rules. The NTP review will be a relatively long-term project that contributes to the overall level of knowledge about FR chemicals among scientists and regulators. NA
Proposed Standard for the Flammability (Open Flame) of Mattresses and Mattress/Foundation Sets; Notice of Proposed Rulemaking The Commission is proposing a flammability standard under the authority of the Flammable Fabrics Act that would address open flame ignition of mattresses and mattress and foundation sets ("mattresses/sets").

January 13, 2005 -- 70 FR 2470
Additional activities by EPA, The National Toxicology Program (NTP) of the Department of Health and Human Services (DHHS), and the Occupational Safety and Health Administration (OSHA) can provide information about any adverse health effects of FR chemicals and take actions to limit their use if necessary.

Department of Transportation (DOT)

Notice Type Title Summary of Notice NTP Information Cited CASRN
Proposed Proposed Rulemaking To Establish Light-Duty Vehicle Greenhouse Gas Emission Standards and Corporate Average Fuel Economy Standards EPA and NHTSA are issuing this joint proposal to establish a National Program consisting of new standards for light-duty vehicles that will reduce greenhouse gas emissions and improve fuel economy. This joint proposed rulemaking is consistent with the National Fuel Efficiency Policy announced by President Obama on May 19, 2009, responding to the country’s critical need to address global climate change and to reduce oil consumption. EPA is proposing greenhouse gas emissions standards under the Clean Air Act, and NHTSA is proposing Corporate Average Fuel Economy standards under the Energy Policy and Conservation Act, as amended. These standards apply to passenger cars, light-duty trucks, and medium-duty passenger vehicles, covering model years 2012 through 2016, and represent a harmonized and consistent National Program. Under the National Program, automobile manufacturers would be able to build a single light-duty national fleet that satisfies all requirements under both programs while ensuring that consumers still have a full range of vehicle choices.

September 28, 2009 -- 74 FR 49553
The National Toxicology Program in its Report on Carcinogens has characterized many components of automobile and truck engines to be known or potential carcinogens. They are benzene, 1, 3-butadiene, acetaldehyde, and naphthalene.  (ROC) 71-43-2
106-99-0
75-07-0
91-20-3

Department of Treasury (Treasury)

Notice Type Title Summary of Notice NTP Information Cited CASRN
Final Rule Removal of Requirement to Disclose Saccharin in the Labeling of Wine, Distilled Spirits, and Malt Beverages The Department of the Treasury is removing the requirement for bottlers of wine, distilled spirits, and malt beverages to show a warning on products containing saccharin.

June 16, 2004 -- 69 FR 33573
Since 1981, saccharin had been listed in the Report on Carcinogens as reasonably anticipated to be a human carcinogen. However, it was delisted in the 9th Report on Carcinogens. The NTP determined that the rodent cancer data is insufficient to meet the current criteria to list the chemical as reasonably anticipated to be a human carcinogen. This is based on the perception that the observed bladder tumors in rats arise by mechanisms not relevant to humans and the lack of data in humans suggesting a carcinogenic hazard. 81-07-2
Final Rule Removal of Requirement To Disclose Saccharin in the Labeling of Wine, Distilled Spirits, and Malt Beverages Amends the Alcohol and Tobacco Tax and Trade Bureau's labeling regulations to remove the requirement for bottlers of wine, distilled spirits, and malt beverages to show a warning on products containing saccharin. The regulatory amendments in this document reflect the National Toxicology Program's revised findings about saccharin and the removal of the statutory requirement for the warning.

June 16, 2004 -- 69 FR 33572
On May 15, 2000, the U.S. Department of Health and Human Services, Public Health Service, National Toxicology Program published the 9th Report on Carcinogens. The report delisted saccharin, which had been listed in the Report as "reasonably anticipated to be a human carcinogen" since 1981. The Report explained that saccharin was removed from the list after a review of the carcinogenicity data for saccharin concluded that rodent cancer data are not sufficient to meet the current criteria to list this chemical as reasonably anticipated to be a human carcinogen based on the perception that the observed bladder tumors in rats arise by mechanisms not relevant to humans, and the lack of data in humans suggesting a carcinogenic hazard. 81-07-2

Environmental Protection Agency (EPA)

Notice Type Title Summary of Notice NTP Information Cited CASRN
Proposed Public Availability of Identities of Inert Ingredients in Pesticides In response to two petitions seeking disclosure of selected inert ingredients on pesticide labels, based on hazard, EPA is initiating rulemaking to increase public availability of the identities of the inert ingredients in pesticide products. This action would assist consumers and users of pesticides in making informed decisions and reduce the presence of potentially hazardous ingredients in pesticides.

December 23, 2009 -- 74 FR 68215
Suggested hazard criteria, which could be used to identify potential carcinogenic substances to be listed in the ingredient statement, include (1) known or presumed human carcinogens and those classified as Group 1 or Group 2 by the International Agency for Research on Cancer (IARC); (2) evidence of carcinogenic activity by the National Toxicology Program (NTP) and/or the Environmental Protection Agency (EPA); and/or (3) a Category I Potential Carcinogen by the Occupational Safety and Health Administration (OSHA). NA
Notice Agency Information Collection Activities; Proposed Collection; Comment Request; Analysis of Archived Environmental Samples From the American Healthy Homes Survey (New); EPA ICR No. XXXX.XX, OMB Control No. 20XX–XXXX In compliance with the Paperwork Reduction Act (PRA) (44 U.S.C. 3501 et seq.), this document announces that EPA is planning to submit a request for a new Information Collection Request (ICR) to the Office of Management and Budget (OMB). Before submitting the ICR to OMB for review and approval, EPA is soliciting comments on specific aspects of the proposed information collection as described below.

November 03, 2009 -- 74 FR 56831

NTP Work Cited: Phthalates are used in the manufacture of a wide range of industrial and household consumer products to prolong durability and increase the flexibility of plastics and as chemical stabilizers for other materials. Animal data suggest a broad spectrum of potential health outcomes including developmental toxicity, endocrine disruption, and carcinogenicity. However, the characterization of human exposure to phthalates is limited and the National Toxicology Program’s Center for the Evaluation of the Risks to Human Reproduction has concluded that more data regarding the potential for human exposure are needed. 

OHAT (formerly CERHR) Evaluations and Workshops, see phthalates. (OHAT)

NA
Proposed Lead; Amendment to the Opt-out and Recordkeeping Provisions in the Renovation, Repair, and Painting Program EPA proposes several revisions to the Lead Renovation, Repair, and Painting Program (RRP) rule that published in the Federal Register on April 22, 2008. The rule establishes accreditation, training, certification, and recordkeeping requirements, as well as work practice standards on persons performing renovations for compensation in most pre-1978 housing and child-occupied facilities. In this document, EPA proposes eliminating the ‘‘opt-out’’ provision that currently exempts a renovation firm from the training and work practice requirements of the rule where the firm obtains a certification from the owner of a residence he or she occupies that no child under age 6 or pregnant women resides in the home and the home is not a child- occupied facility. EPA also proposes requiring renovation firms to provide a copy of the records demonstrating compliance with the training and work practice requirements of the RRP rule to the owner and, if different, the occupant of the building being renovated or the operator of the child-occupied facility.

October 28, 2009 -- 74 FR 55506
Lead exerts ‘‘a broad array of deleterious effects on multiple organ systems via widely diverse mechanisms of action’’. Health effects include impacts on heme biosynthesis and related functions, neurological development and function, reproduction and physical development, kidney function, cardiovascular function, and immune function. There is also some evidence of lead carcinogenicity, primarily from animal studies, together with limited human evidence of suggestive associations. (Lead) 7439-92-1
Proposed Proposed Rulemaking To Establish Light-Duty Vehicle Greenhouse Gas Emission Standards and Corporate Average Fuel Economy Standards EPA and NHTSA are issuing this joint proposal to establish a National Program consisting of new standards for light-duty vehicles that will reduce greenhouse gas emissions and improve fuel economy. This joint proposed rulemaking is consistent with the National Fuel Efficiency Policy announced by President Obama on May 19, 2009, responding to the country’s critical need to address global climate change and to reduce oil consumption. EPA is proposing greenhouse gas emissions standards under the Clean Air Act, and NHTSA is proposing Corporate Average Fuel Economy standards under the Energy Policy and Conservation Act, as amended. These standards apply to passenger cars, light-duty trucks, and medium-duty passenger vehicles, covering model years 2012 through 2016, and represent a harmonized and consistent National Program. Under the National Program, automobile manufacturers would be able to build a single light-duty national fleet that satisfies all requirements under both programs while ensuring that consumers still have a full range of vehicle choices.

September 28, 2009 -- 74 FR 49553
The National Toxicology Program in its Report on Carcinogens has characterized many components of automobile and truck engines to be known or potential carcinogens. They are benzene, 1, 3-butadiene, acetaldehyde, and naphthalene. (ROC) 71-43-2
106-99-0
75-07-0
91-20-3
Final Rule Amine Salts of Alkyl (C8-C24) Benzenesulfonic Acid (Dimethylaminopropylamine, Isopropylamine, Mono-, Di-, and Triethanolamine); Exemption from the Requirement of a Tolerance This regulation establishes an exemption from the requirement of a tolerance for residues of amine salts of alkyl (C8-C24) benzenesulfonic acid (dimethylaminopropylamine, isopropylamine, mono-, di-, and triethanolamine) when used as an inert ingredient in pesticide formulations applied to growing crops and applied to animals. The Joint Inerts Task Force, Cluster Support Team Number 8, submitted a petition to EPA under the Federal Food, Drug, and Cosmetic Act (FFDCA), requesting an exemption from the requirement of a tolerance. This regulation eliminates the need to establish a maximum permissible level for residues of amine salts of alkyl (C8-C24) benzenesulfonic acid (dimethyl aminopropylamine, isopropylamine, mono-, di, and triethanolamine).

August 05, 2009 -- 74 FR 38924
Subchronic (13-week) oral toxicity study in rats (NTP, 1992). (Diethanolamine) 111-42-2
Final Rule Residues of Silver in Foods from Food Contact Surface Sanitizing Solutions; Exemption from the Requirement of a Tolerance This regulation amends the exemption from the requirement of a tolerance for residues of silver (excludes silver salts) in or on all foods when applied or used in public eating places, dairy processing equipment, and food processing equipment. ETO H2O, Inc., submitted a petition to EPA under the Federal Food, Drug, and Cosmetic Act requesting to establish concentration limits for silver in end-use solutions eligible for tolerance exemption. The regulation being established will exempt all foods from the requirement of a tolerance for residues of silver resulting from contact with surfaces treated with solutions in which the end-use concentration of silver is not to exceed 50 parts per million (ppm).

June 10, 2009 -- 74 FR 27447
There are extensive data and analysis on silvers toxicity in the historical data/literature and the regulatory advisories established by other Federal Agencies, which do not indicate an increased susceptibility of children to the toxic effects of silver. A NTP developmental toxicity study concluded that the NOAEL recorded for developmental toxicity in rats receiving gavage doses of silver acetate was greater than 100 mg/ kg when the test material was administered on gestation days 6 through 19. No increase in susceptibility was apparent in this study. NA
Proposed Regulation of Fuels and Fuel Additives: Changes to Renewable Fuel Standard Program Under the Clean Air Act, as amended by Sections 201, 202, and 210 of the Energy Independence and Security Act of 2007, the Environmental Protection Agency is required to promulgate regulations implementing changes to the Renewable Fuel Standard program.

May 26, 2009 -- 74 FR 25053
Acetaldehyde is reasonably anticipated to be a human carcinogen by the U.S. DHHS in the 11th Report on Carcinogens. (Acetaldehyde) The U.S. Department of Health and Human Services (DHHS) has characterized benzene as a known human carcinogen. (Benzene) The U.S. DHHS has characterized 1,3-butadiene as a known human carcinogen. (1,3-Butadiene) The U.S. DHHS in the 11th Report on Carcinogens identified alcoholic beverages as a known human carcinogen (they have not evaluated the cancer risks specifically from exposure to ethanol), with evidence for cancer of the mouth, pharynx, larynx, esophagus, liver and breast. (Ethanol) The National Toxicology Program listed naphthalene as reasonably anticipated to be a human carcinogen in 2004 on the basis of bioassays reporting clear evidence of carcinogenicity in rats and some evidence of carcinogenicity in mice. (Naphthalene ) (ROC) 75-07-0
71-43-2
106-99-0
64-17-5
91-20-3
Final Rule Diflubenzuron; Pesticide Tolerances for Emergency Exemptions This regulation establishes time-limited tolerances for combined residues of diflubenzuron and its metabolites p-chlorophenylurea and p-chloroaniline in or on alfalfa, forage and alfalfa, hay. This action is in response to EPAs granting of an emergency exemption under section 18 of the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) authorizing use of the pesticide on alfalfa and mixed grass/alfalfa fields. This regulation establishes a maximum permissible level for residues of diflubenzuron and its metabolites p-chlorophenylurea and p-chloroaniline, in these food commodities. The time-limited tolerances expire and are revoked on December 31, 2011.

November 28, 2008 -- 73 FR 72352
There are two metabolites of diflubenzuron; PCA and CPU. PCA tested positive for splenic tumors in male rats and hepatocellular adenomas/carcinomas in male mice in a National Toxicology Program (NTP) study. (TR-351) 20265-96-7
Final Rule Inert Ingredient: Exemption from the Requirement of a Tolerance for (S,S)­Ethylene­di­amine­di­succinic Acid This regulation establishes an exemption from the requirement of a tolerance for residues of (S,S)­Ethylene­di­amine­di­succinic Acid (CAS Reg. No. 20846-91-7) ((S,S)EDDS) when used as an inert ingredient sequestrant or chelating agent in pesticide formulations applied to growing crops only under 40 CFR 180.920. Associated Octel Company, Limited, submitted a petition to EPA under the Federal Food, Drug, and Cosmetic Act (FFDCA), as amended by the Food Quality Protection Act of 1996 (FQPA), requesting an exemption from the requirement of a tolerance. This regulation eliminates the need to establish a maximum permissible level for residues of (S,S)Ethylenediaminedisuccinic acid.

November 14, 2008 -- 73 FR 67397
No carcinogenicity studies are available on (S,S)EDDS, however, NTP tested trisodium EDTA in mice and rats showed no carcinogenic potential. Based on its similarity with EDTA and lack of mutagenicity, (S,S)EDDS is not likely to be carcinogenic to humans at low doses. (TR-011) CAS No. 150-38-9
Final Rule National Ambient Air Quality Standards for Lead Based on its review of the air quality criteria and national ambient air quality standards (NAAQS) for lead (Pb), EPA is making revisions to the primary and secondary NAAQS for Pb to provide requisite protection of public health and welfare, respectively. With regard to the primary standard, EPA is revising the level to 0.15 μg/m3. EPA is retaining the current indicator of Pb in total suspended particles (Pb-TSP). EPA is revising the averaging time to a rolling 3-month period with a maximum (not-to-be-exceeded) form, evaluated over a 3-year period. EPA is revising the secondary standard to be identical in all respects to the revised primary standard.

November 12, 2008 -- 73 FR 66964

Lead has been classified as a probable human carcinogen by the International Agency for Research on Cancer (inorganic lead compounds), based mainly on sufficient animal evidence, and as reasonably anticipated to be a human carcinogen by the U.S. National Toxicology Program (lead and lead compounds). ROC

NA
Notice Sixty-Third Report of the TSCA Interagency Testing Committee to the Administrator of the Environmental Protection Agency; Receipt of Report and Request for Comments The Toxic Substances Control Act (TSCA) Interagency Testing Committee (ITC) transmitted its 63rd Report to the Administrator of the EPA on October 7, 2008. In the 63rd ITC report, which is included with this notice, the ITC is revising the TSCA section 4(e) Priority Testing List by removing 1 tungsten compound and 1 High Production Volume (HPV) Challenge Program orphan chemical.

November 03, 2008 -- 73 FR 65486
At this time the ITC is removing tungstate (WO42-), disodium, dihydrate, (T-4)-, a.k.a. disodium tungstate (Na2WO4) dihydrate (CAS No. 10213-10-2) from the Priority Testing List because of the voluntary information provided by the International Tungsten Industry Association and their cooperation in a National Toxicology Program/National Institute for Occupational Safety and Health research program to address exposure and toxicity data needs. 10213-10-2
Final Rule Control of Emissions From Nonroad Spark-Ignition Engines and Equipment We are setting emission standards for new non-road spark-ignition engines that will substantially reduce emissions from these engines. The exhaust emission standards apply starting in 2010 for new marine spark-ignition engines, including first-time EPA standards for stern-drive and inboard engines. The exhaust emission standards apply starting in 2011 and 2012 for different sizes of new land-based, spark-ignition engines at or below 19 kilowatts (kW). These small engines are used primarily in lawn and garden applications. We are also adopting evaporative emission standards for vessels and equipment using any of these engines. In addition, we are making other minor amendments to our regulations.

October 08, 2008 -- 73 FR 59034
The International Agency for Research on Carcinogens (IARC) has determined that benzene is a human carcinogen and the U.S. Department of Health and Human Services (DHHS) has characterized benzene as a known human carcinogen. (ROC)

The IARC has determined that 1,3-butadiene is a human carcinogen and the U.S. DHHS has characterized 1,3-butadiene as a known human carcinogen. (ROC)

Acetaldehyde is reasonably anticipated to be a human carcinogen by the U.S. DHHS in the 11th Report on Carcinogens and is classified as possibly carcinogenic to humans (Group 2B) by the IARC. (ROC)

The National Toxicology Program listed naphthalene as "reasonably anticipated to be a human carcinogen" in 2004 on the basis of bioassays reporting clear evidence of carcinogenicity in rats and some evidence of carcinogenicity in mice. (ROC)
71-43-2
106-99-0
75-07-0
91-20-3
Other Dichlorvos (DDVP); Order Denying NRDCs Objections and Requests for Hearing In this order, EPA denies objections to, and requests for hearing on, a prior order denying a petition requesting that EPA revoke all pesticide tolerances for dichlorvos under section 408(d) of the Federal Food, Drug, and Cosmetic Act. The objections and hearing requests were filed on February 1, 2008, by the Natural Resources Defense Council (NRDC). The Original petition was also filed by NRDC.

July 23, 2008 -- 73 FR 42683
In the 1989 NTP cancer studies with rats and mice, male and female reproductive organs (prostate, testes, epididymis, ovaries, uterus) were examined and no changes attributable to DDVP were found. (TR-342) 62-73-7
Final Rule Control of Emissions of Air Pollution from Locomotive Engines and Marine Compression-Ignition Engines Less than 30 Liters per Cylinder; Republication EPA is adopting a comprehensive program to dramatically reduce pollution from locomotives and marine diesel engines. The controls will apply to all types of locomotives, including line-haul, switch, and passenger, and all types of marine diesel engines below 30 liters per cylinder displacement, including commercial and recreational, propulsion and auxiliary. The near-term emission standards for newly-built engines will phase in starting in 2009. The near-term program also includes new emission limits for existing locomotives and marine diesel engines that apply when they are remanufactured, and take effect as soon as certified remanufacture systems are available, as early as 2008. The long-term emissions standards for newly-built locomotives and marine diesel engines are based on the application of high-efficiency catalytic after-treatment technology. These standards begin to take effect in 2015 for locomotives and in 2014 for marine diesel engines. We estimate particulate matter (PM) reductions of 90 percent and nitrogen oxides (NOX) reductions of 80 percent from engines meeting these standards, compared to engines meeting the current standards.

June 30, 2008 -- 73 FR 37096
The National Toxicology Program listed naphthalene as "reasonably anticipated to be a human carcinogen" in 2004 on the basis of bioassays reporting clear evidence of carcinogenicity in rats and some evidence of carcinogenicity in mice. (ROC) 

The IARC has determined that benzene is a human carcinogen and the U.S. DHHS has characterized benzene as a known human carcinogen. (ROC)

The IARC has determined that 1,3-butadiene is a human carcinogen and the U.S. DHHS has characterized 1,3-butadiene as a known human carcinogen. (ROC)

Acetaldehyde is reasonably anticipated to be a human carcinogen by the U.S. Department of Health and Human Services (DHHS) in the 11th Report on Carcinogens and is classified as possibly carcinogenic to humans (Group 2B) by the International Agency for Research on Carcinogens (IARC). (ROC)

91-20-3
71-43-2
106-99-0
75-07-0
Notice Sixty-Second Report of the TSCA Interagency Testing Committee to the Administrator of the Environmental Protection Agency; Receipt of Report and Request for Comments The Toxic Substances Control Act (TSCA) Interagency Testing Committee (ITC) transmitted its sixty-second report to the Administrator of EPA on April 17, 2008. In the 62nd ITC Report, which is included with this notice, the ITC is revising the TSCA section 4(e) Priority Testing List by removing four tungsten compounds and four cresols.

May 12, 2008 -- 73 FR 27450
The ITC is removing tungsten oxide (WO3), a.k.a. tungsten trioxide because of the voluntary information provided by the International Tungsten Industry Association and their cooperation in a National Toxicology Program/National Institute for Occupational Safety and Health research program to address exposure and toxicity data needs. The ITC is retaining tungstate (WO42-), disodium, dihydrate, (T-4)-, a.k.a. sodium tungstate (Na2 (WO4)), dihydrate (CAS No. 10213-10-2), on the Priority Testing List because of ongoing discussions with the International Tungsten Industry Association. 1314-35-8
10213-10-2
Notice Draft Toxicological Review of Tetrahydrofuran: In Support of the Summary Information in the Integrated Risk Information System (IRIS) EPA is announcing that the Oak Ridge Institute of Science and Education (ORISE), under an Interagency agreement between the Department of Energy and EPA, will convene an independent panel of experts and organize and conduct an external peer-review workshop to review the external review draft document titled, "Toxicological Review of Tetrahydrofuran: In Support of Summary Information on the Integrated Risk Information System (IRIS" (NCEA-S-1620). The EPA also is announcing a public comment period for the draft document. EPA intends to consider comments and recommendations from the public and the expert panel meeting when EPA finalizes the draft document.

August 20, 2007 -- 72 FR 46483
The National Toxicology Program studies referenced in the Toxicological Review of Tetrahydrofuran are available by calling EPA's IRIS Hotline at 202-566-1676, by fax at 202-566-1749 or by e-mail at iris@epa.gov. 109-99-9
Notice Draft Toxicological Review of Bromobenzene: In Support of the Summary Information in the Integrated Risk Information System (IRIS) EPA is announcing that the Oak Ridge Institute of Science and Education (ORISE), under an Interagency agreement between the Department of Energy and EPA, will convene an independent panel of experts and organize and conduct an external peer-review workshop to review the external review draft document titled, "Toxicological Review of Bromobenzene: In Support of Summary Information on the Integrated Risk Information System (IRIS" (NCEA-C-1497). The EPA also is announcing a public comment period for the draft document. EPA intends to consider comments and recommendations from the public and the expert panel meeting when EPA finalizes the draft document.

June 14, 2007 -- 72 FR 32847
If you are requesting a paper copy, please provide your name, mailing address, and the document title. Copies are not available from ORISE. The National Toxicology Program studies referenced in the Toxicological Review of Bromobenzene are available by calling EPA's IRIS Hotline at (202) 566-1676, by fax at (202) 566-1749 or by e-mail at iris@epa.gov.
Final Rule Protection of Stratospheric Ozone: Listing of Substitutes for Ozone-Depleting Substances-n-Propyl Bromide in Solvent Cleaning The Environmental Protection Agency (EPA) determines that n-propyl bromide (nPB) is an acceptable substitute for methyl chloroform and chlorofluorocarbon (CFC)-113 in the solvent cleaning sector under the Significant New Alternatives Policy (SNAP) program under section 612 of the Clean Air Act. The SNAP program reviews alternatives to Class I and Class II ozone depleting substances and approves use of alternatives which do not present a substantially greater risk to public health and the environment than the substance they replace or than other available substitutes.

May 30, 2007 -- 72 FR 30142
These metabolic and subchronic inhalation studies conducted under the National Toxicology Program did not specifically examine for reproductive toxicity or nPB metabolism in target organs that control reproductive function. In summary, there is little available data about the metabolic activation or reactive metabolites responsible for reproductive toxicity in rodents. Similarly, for nPB, there is little information available about differences and similarities between rodents and humans.
Final Rule Diflubenzuron; Pesticide Tolerances This regulation establishes tolerances for combined residues of diflubenzuron and its metabolites 4-chlorophenylurea and 4-chloroaniline in or on brassica, leafy greens subgroup 5B, turnip greens, peanut, peanut hay, peanut oil, barley grain, barley hay, barley straw, oat grain, oat forage, oat hay, oat straw, wheat grain, wheat forage, wheat hay, wheat straw, aspirated grain fractions, and pummelo. The Interregional Research Project #4 requested these tolerances under the Federal Food, Drug, and Cosmetic Act (FFDCA), as amended by the Food Quality Protection Act of 1996 (FQPA).

November 29, 2006 -- 71 FR 69028
The Agency has classified diflubenzuron as "Group E," evidence of non-carcinogenicity for humans, based on lack of evidence of carcinogenicity in rats and mice. There are also two metabolites of diflubenzuron; PCA and CPU. PCA tested positive for splenic tumors in male rats and hepatocellular adenomas/ carcinomas in male mice in a National Toxicology Program (NTP) study. (TR-351) 35367-38-5
150-68-5
106-47-8
Final Rule Export Notification; Change to Reporting Requirements EPA is promulgating amendments to the Toxic Substances Control Act (TSCA) section 12(b) export notification regulations at subpart D of 40 CFR part 707. One amendment changes the current annual notification requirement to a one-time requirement for exporters of chemical substances or mixtures (hereinafter referred to as "chemicals") for which certain actions have been taken under TSCA. Relatedly, for the same TSCA actions, EPA is changing the current requirement that the Agency notify foreign governments annually after the Agency's receipt of export notifications from exporters to a requirement that the Agency notify foreign governments once after it receives the first export notification from an exporter. EPA is also promulgating de minimis concentration levels below which notification will not be required for the export of any chemical for which export notification under TSCA section 12(b) is otherwise required, promulgating other minor amendments (to update the EPA addresses to which export notifications must be sent, to indicate that a single export notification may refer to more than one section of TSCA where the exported chemical is the subject of multiple TSCA actions, and to correct an error in 40 CFR 799.19 that currently omits mentioning multi-chemical test rules as being among those final TSCA section 4 actions that trigger export notification), and clarifying exporters' and EPA's obligations where an export notification- triggering action is taken with respect to a chemical previously or currently subject to export notification due to the existence of a previous triggering action.

November 14, 2006 -- 71 FR 66234
EPA will consider the lists maintained by the World Health Organization, International Agency for Research on Cancer (IARC) and the US Department of Health and Human Services, Public Health Service, National Toxicology Program (NTP) as the definitive sources. The NTP Report on Carcinogens is mandated by section 301(b)(4) of the Public Health Service Act, as amended (42 U.S.C. 201 et seq.), which stipulates that the Secretary of the Department of Health and Human Services shall publish an annual report which contains a list of all substances: • Which either are known to be carcinogens in humans or may reasonably be anticipated to be human carcinogens • To which a significant number of persons residing in the United States are exposed. (ROC)
Proposed Proposed Test Rule for Certain Chemicals on the ATSDR/EPA CERCLA Priority List of Hazardous Substances EPA is proposing to require testing for certain chemicals on the Agency for Toxic Substances and Disease Registry (ATSDR)/EPA Priority List of Hazardous Substances which is compiled under the Comprehensive Environmental Response Compensation and Liability Act (CERCLA), and is soliciting proposals for enforceable consent agreements (ECAs). EPA is proposing a test rule under section 4(a) of the Toxic Substances Control Act (TSCA) that would require manufacturers (including importers) and processors of four chemical substances (chloroethane, hydrogen cyanide, methylene chloride, and sodium cyanide) to conduct testing for certain health effects relating to the manufacture, distribution in commerce, processing, use, or disposal of these substances.

October 20, 2006 -- 71 FR 61926
The toxicological profiles are developed by ATSDR in collaboration with EPA and NTP, independent peer reviewers, and the public.
Notice Request for Nominations of Drinking Water Contaminants for the Contaminant Candidate List The Environmental Protection Agency (EPA) is requesting nominations of chemical and microbial contaminants for possible inclusion in the third drinking water Contaminant Candidate List (CCL 3). EPA is also requesting information that shows the nominated contaminant may have an adverse health effect on people and the contaminant occurs or is likely to occur.

September 16, 2006 -- 71 FR 60704
Final Rule Eucalyptus Oil; Exemption from the Requirement of a Tolerance This regulation establishes an exemption from the requirement of a tolerance for residues of eucalyptus oil on honey and honeycomb when applied at 2 g or less eucalyptus oil per hive to suppress varroa mites. Brushy Mountain Bee farm, c/o IR-4 Project submitted a petition to EPA under the Federal Food, Drug, and Cosmetic Act (FFDCA), as amended by the Food Quality Protection Act of 1996 (FQPA), requesting an exemption from the requirement of a tolerance. This regulation eliminates the need to establish a maximum permissible level for residues of eucalyptus oil in honey and honeycomb.

September 13, 2006 -- 71 FR 53974
National Toxicology Program. 1982. Salmonella assay for genetic toxicity from exposure to 1,8 cineole. Study 246429.

National Toxicology Program. 1982. CHO cell cytogenetics; chromosome aberrations and sister chromatid exchanges from exposure to 1,8 cineole. Study 590755.
470-82-6
Final Rule Ethylene Oxide Emissions Standards for Sterilization Facilities This action finalizes our decision not to revise the Ethylene Oxide Emission Standards for Sterilization Facilities, originally promulgated on December 6, 1994. Within 8 years of promulgating these standards, the Clean Air Act directs us to assess the risk and to promulgate more stringent standards if necessary to protect public health with an ample margin of safety and to prevent adverse environmental effects. Also, within 8 years of promulgating the national emission standards, the Clean Air Act requires us to review and revise the standards as necessary, taking into account developments in practices, processes, and control technologies. Today¿s action reflects our findings that after conducting these risk and technology reviews, no additional control requirements are warranted.

April 07, 2006 -- 71 FR 17712
In 1994, the International Agency for Research on Cancer categorized ethylene oxide in their Group 1 (Carcinogenic to Humans). In 2000, the United States Department of Health and Human Services revised its listing for ethylene oxide to "known to be a human carcinogen" in the Ninth Report on Carcinogens.

DHHS. 2000. Report on Carcinogens, Eleventh Edition; United States Department of Health and Human Services, Public Health Service, National Toxicology Program.
(ROC)
Final Rule Testing of Certain High Production Volume Chemicals EPA is promulgating a final rule under the Toxic Substances Control Act that requires manufacturers (including importers) and processors of 17 high production volume chemicals to conduct acute toxicity, repeat dose toxicity, developmental and reproductive toxicity, genetic toxicity (gene mutations and chromosomal aberrations), ecotoxicity (in fish, Daphnia, and algae), and environmental fate (including 5 tests for physical chemical properties and biodegradation) testing.

March 16, 2006 -- 71 FR 13708
With one exception, the "Class 1" chemical substances listed in Table 2 in § 799.5085(j) of the regulatory text (i.e., 12 of the 17 chemical substances included in this final rule) must be tested at a purity of at least 99%. The exception is 1,3-propanediol, 2,2-bis[(nitrooxy)methyl]-,dinitrate (ester) also known as pentaerythritol tetranitrate (PETN), which cannot be tested at 99% purity because of its explosive properties and must either be diluted in water or tested in a mixture with an appropriate stabilizing compound (e.g., D-lactose monohydrate is the stabilizer in PETN, NF which is a mixture that is 20% by weight PETN and 80% by weight Dlactose monohydrate). PETN, NF is the form of PETN which was tested by NTP in several toxicity studies.

U.S. Department of Health and Human Services. National Institutes of Health. NTP. Toxicology and carcinogenesis studies of pentaerythritol tetranitrate in F344/N rats and B6C3F1 mice (feed studies). (TR-365)
78-11-5
Proposed Ethylenediaminetetraacetic Acid Chemicals: Exemptions from the Requirement of a Tolerance The Agency is proposing to establish 16 new and amend three existing exemptions from the requirement of a tolerance for residues of various ethylenediaminetetraacetic acid (EDTA) chemicals in or on raw agricultural commodities when used as inert ingredients in pesticide formulations applied to growing crops or to raw agricultural commodities after harvest under the Federal Food, Drug, and Cosmetic Act (FFDCA), as amended by the Food Quality Protection Act of 1996 (FQPA). This regulation eliminates the need to establish a maximum permissible level for residues of these EDTA chemicals.

March 08, 2006 -- 71 FR 11563
The toxicological profile data considered in this assessment included information located by the Office of Pesticide Programs on the internet, studies conducted by the National Toxicology Program (NTP) and the National Cancer Institute (NCI), several work products produced by the Cosmetic Ingredient Review, several evaluations by the World Health Organization, and articles from open literature.

Based on the available toxicity data on ethylenediaminetetraacetic acid (EDTA) and its various salts, with particular emphasis on the comparison of the findings in the two developmental toxicity studies; the reviews and evaluations conducted by NTP, NCI, and WHO; the knowledge that trace metal supplementation occurs via the food and drinking water consumed by human beings; and considering the estimated exposures of the wide-spread existing uses of ethylenediaminetetraacetic acid (EDTA) and its various salts which are less than levels at which adverse effects were noted, EPA concludes that there is a reasonable certainty of no harm from aggregate exposure to residues of ethylenediaminetetraacetic acid (EDTA) and its various salts. (TR-11)

150-38-9
Final Rule National Primary Drinking Water Regulations: Stage 2 Disinfectants and Disinfection Byproducts Rule The Environmental Protection Agency (EPA) is promulgating today's final rule, the Stage 2 Disinfectants and Disinfection Byproducts Rule (DBPR), to provide for increased protection against the potential risks for cancer and reproductive and developmental health effects associated with disinfection byproducts (DBPs).

January 04, 2006 -- 71 FR 388
Two-year bioassays by the National Toxicology Program (NTP) released in abstract form have recently been completed on BDCM and chlorate. The draft abstract on BDCM reported no evidence of carcinogenicity when BDCM was administered via drinking water (NTP 2005a). Another recent study, a modified two-year bioassay on BDCM in the drinking water, reported little evidence of carcinogenicity (George et al. 2002). In a previous NTP study, tumors were observed, including an increased incidence of kidney, liver, and colon tumors, when BDCM was administered at higher doses by gavage in corn oil (NTP 1987). EPA will examine new information on BDCM as it becomes available. In the chlorate draft abstract, NTP found some evidence that it may be a carcinogen (NTP 2004). Chlorate is a byproduct of hypochlorite and chlorine dioxide systems. A long-term, two-year bioassay NTP study on DBA is also complete but has not yet undergone peer review (NTP 2005b). (TR-321) (TR-532) (GMM-5) (TR-517) (TR-537) 75-27-4
7775-09-9
and 631-64-1
Proposed National Perchloroethylene Air Emission Standards for Dry Cleaning Facilities EPA is proposing revised standards to limit emissions of perchloroethylene (PCE) from existing and new dry cleaning facilities.

December 21, 2005 -- 70 FR 75884
NTP technical report on the toxicology and carcinogenesis of tetrachloroethylene (perchloroethylene) (CAS No. 127-18-4) in F344/N rats and B6C3F1 mice (inhalation studies) National Toxicology Program, Research Triangle Park, NC. (TR-311), NIH Publication No. 86-2567. August 1986. 127-18-4
Final Rule List of Hazardous Air Pollutants, Petition Process, Lesser Quantity Designations, Source Category List EPA is amending the list of hazardous air pollutants contained in section 112 of the Clean Air Act by removing the compound methyl ethyl ketone (MEK) (2-Butanone) (CAS No. 78-93-3). This action is being taken in response to a petition submitted by the Ketones Panel of the American Chemistry Council (formerly the Chemical Manufacturers Association) on behalf of MEK producers and consumers to delete MEK from the HAP list. Petitions to remove a substance from the HAP list are permitted under section 112 of the CAA.

December 19, 2005 -- 70 FR 75047
There is an absence of positive results in the majority of mutagenicity and genotoxicity tests which are designed to indicate the potential for carcinogenicity. Methyl ethyl ketone has been tested for activity in an extensive spectrum of in vitro and in vivo genotoxicity assays and has shown no evidence of genotoxicity in most conventional assays (National Toxicology Program, no date; World Health Organization 1992; Zeiger et al., 1992).

While developing the final rule, EPA learned that preliminary results of a recent cancer bioassay by the National Toxicology Program suggested that methyl isobutyl ketone (MIBK) appears to be a weak or marginally active carcinogen in rats and mice, possibly by a nongenotoxic mode of action. (TR-538)
78-93-3
108-10-1
Final Rule Pinene Polymers; Exemption from the Requirement of a Tolerance This regulation establishes exemptions from the requirement of a tolerance for residues of several alpha and/or beta-pinene polymers when used as inert ingredients in or on growing crops and when applied to raw agricultural commodities after harvest. Hercules, Inc. submitted a petition to EPA under the Federal Food, Drug, and Cosmetic Act (FFDCA), as amended by the Food Quality Protection Act of 1996 (FQPA), requesting an exemption from the requirement of a tolerance. This regulation eliminates the need to establish a maximum permissible level for residues of alpha and/or beta-pinene polymers.

May 18, 2005 -- 70 FR 28447
The data considered in this assessment included information submitted by the petitioner, and information located by OPP on the internet, primarily information prepared by the National Toxicology Program (NTP) and the robust summaries for bicyclic terpene hydrocarbons submitted in 2002 to EPA by the Terpene Consortium of the Flavor and Fragrance High Production Volume Consortia (FFHPVC).
Notice Isophorone; Notice of Filing a Pesticide Petition to Establish a Tolerance for a Certain Pesticide Chemical in or on Food This notice announces the initial filing of a pesticide petition proposing the establishment of regulations for residues of a certain pesticide chemical in or on various food commodities.

April 27, 2005 -- 70 FR 21767
In an oral gavage chronic toxicity/oncogenicity study conducted by the National Toxicology Program at dose levels of 0, 250 and 500 mg/kg/day in F344 rats and B6C3F1 mice, there was some evidence of carcinogenicity of isophorone in male rats (kidney tumors, preputial gland carcinomas). (TR-291) 78-59-1
Final Rule List of Hazardous Air Pollutants, Petition Process, Lesser Quantity Designations, Source Category List; Petition To Delist of Ethylene Glycol Monobutyl Ether The EPA is amending the list of hazardous air pollutants contained in section 112(b)(1) of the Clean Air Act by removing the compound ethylene glycol monobutyl ether (EGBE) (2-Butoxyethanol)(CAS No. 111-76-2) from the group of glycol ethers.

November 29, 2004 -- 69 FR 69320
In the preamble to the proposed rule, we stated that the Agency believes EGBE is not genotoxic and that two distinctly different nonlinear modes of action are principally responsible for the increased forestomach and liver tumors reported by NTP (TR-494). 111-76-2
Final Rule National Emission Standards for Hazardous Air Pollutants for Industrial, Commercial, and Institutional Boilers and Process Heaters The EPA is promulgating national emission standards for hazardous air pollutants for industrial, commercial, and institutional boilers and process heaters and has identified industrial, commercial, and institutional boilers and process heaters as major sources of hazardous air pollutants.

September 13, 2004 -- 69 FR 55217
A NTP study (TR-392) showed no evidence of carcinogenic activity in male rats or male and female mice, and equivocal evidence in female rats, from ingestion of chlorinated water. The EPA has not classified chlorine for potential carcinogenicity. 7782-50-5
7681-52-9
Proposed National Emission Standards for Hazardous Air Pollutants: Proposed Standards for Hazardous Air Pollutants for Hazardous Waste Combustors The EPA proposes national emission standards for hazardous air pollutants (HAPs) for hazardous waste combustors (HWCs). These proposed standards will, when final, implement section 112(d) of the Clean Air Act by requiring HWCs to meet HAP emission standards reflecting the application of the maximum achievable control technology.

April 20, 2004 -- 69 FR 21198
Nickel has been identified as a HAP emitted from HWCs. The EPA used data from the NTP inhalation studies of Nickel (II) Oxide (TR 451) and Nickel Sulfate Hexahydrate (TR 454) in identifying risks associated with exposure to nickel. The 2001 DHHS National Toxicology Program 9th Report on Carcinogens classified 2,3,7,8-TCDD as a known human carcinogen.
1313-99-1
10101-97-0
1746-01-6
Proposed National Emission Standards for Hazardous Air Pollutants: Proposed Standards for Hazardous Air Pollutants for Hazardous Waste Combustors (Phase I Final Replacement Standards and Phase II) This action proposes national emission standards for hazardous air pollutants for hazardous waste combustors including hazardous waste burning incinerators, cement kilns, lightweight aggregate kilns, industrial/commercial/ institutional boilers and process heaters, and hydrochloric acid production furnaces that EPA has identified as major sources of hazardous air pollutant emissions. Proposed standards will implement section 112(d) of the Clean Air Act (CAA) by requiring hazardous waste combustors to meet emission standards.

April 20, 2004 -- 69 FR 21197
In 2001 the DHHS National Toxicology Program classified 2,3,7,8-TCDD as a know human carcinogen in it's 9th Report on Carcinogens.

A pair of inhalation studies (TR-453 and TR-454) performed under the auspices of the National Toxicology Program (NTP) of the National Institutes of Health concluded that there was no evidence of carcinogenic activity of soluble nickel salts in rats or mice and that there was some evidence of carcinogenic activity of nickel oxide (TR-451) in male and female rats based on increased incidence of alveolar/bronchiolar adenoma or carcinoma and increased incidence of benign or malignant pheochromocytoma (a tumor of the adrenal gland) and equivocal evidence in mice based on marginally increased incidence of alveolar/bronchiolar adenoma or carcinoma in females and no evidence in males.

In December 2006, the Tenth Annual Report on Carcinogens classifies nickel compounds as "known to be human carcinogens".
10101-97-0
12035-72-2
1313-99-1
1746-01-6
Notice Fifty-Third Report of the TSCA Interagency Testing Committee to the Administrator of the Environmental Protection Agency; Receipt of Report and Request for Comments The Toxic Substances Control Act (TSCA) Interagency Testing Committee (ITC) transmitted its Fifty-Third Report to the Administrator of the EPA on December 2, 2003 revising the Priority Testing List by adding 3 pyridinamines and 20 tungsten compounds requesting that EPA add the 3 pyridinamines and 20 tungsten compounds to the TSCA section 8(a) Preliminary Assessment Information Reporting (PAIR) rule and soliciting voluntary use, exposure, and effects information for 3 pyridinamines, 20 tungsten compounds, and 43 vanadium compounds through its Voluntary Information Submissions Innovative Online Network.

January 15, 2004 -- 69 FR 2468
Tungsten was nominated for toxicology and carcinogenicity studies to the National Toxicology Program by the Centers for Disease Control and Prevention's National Center for Environmental Health based on recent data showing elevated tungsten body burdens in residents of Fallon, NV, and the limited data available to assess the potential long-term adverse health effects of tungsten exposure. Further information is needed to more fully evaluate human and environmental exposures and health effects. 1314-35-8
Proposed List of Hazardous Air Pollutants, Petition Process, Lesser Quantity Designations, Source Category List The EPA proposes to amend the list of hazardous air pollutants contained in section 112(b)(1) of the Clean Air Act by removing ethylene glycol monobutyl ether from the group of glycol ethers.

November 21, 2003 -- 68 FR 65648
The EPA used data from the NTP's 2-year inhalation study (TR-484) in considering the removal of EGBE from the list of hazardous air pollutants.
111-76-2
Notice National Primary Drinking Water Regulations: Stage 2 Disinfectants and Disinfection Byproducts Rule The EPA is proposing maximum contaminant level goals (MCLGs) for chloroform, monochloroacetic acid and trichloroacetic acid;National Primary Drinking Water Regulations for total trihalomethanes and haloacetic acids; and revisions to the reduced monitoring requirements for bromates.

August 18, 2003 -- 68 FR 49548
The EPA used data from the NTP Toxicology and Carcinogenesis Studies of Bromodichloromethane (TR-321), Tribromomethane (TR-350), and Monochloroacetic Acid (TR-396) in determining the MCLGs for water disinfection byproducts. 79-11-8
75-25-2
75-27-4
Notice Sucrose Octanoate Esters; Exemption from the Requirement of a Tolerance The EPA has established an exemption from the tolerance requirements pursuant to FFDCA 408(c) and 9(d) for residues of certain Sucrose Octanoate Esters (SOEs) in or on all food commodities when applied/used in accordance with good agricultural practices.

September 25, 2002 -- 67 FR 60146
The EPA has determined, based on available toxicology data including data from an NTP genetic toxicology study, that no harm will result from aggregate exposure of residues of SOEs to the U.S. population. 124-07-2
Notice Indirect Food Additives: Polymers The EPA is soliciting public comment on whether a preliminary determination that nine contaminants do not meet all three Safe Drinking Water Act requirements is appropriate, and thus no National Primary Drinking Water Regulations (NPDWR) should be considered for these contaminants.

June 03, 2002 -- 67 FR 38222
The EPA used data from the NTP Toxicity Studies of Hexachloro-1,3-butadiene, (TOX- 1) and Naphthalene (TR-410) & (TR-500) in determining that NPDWRs should not be considered for these contaminants. 91-20-3
87-68-3
Final Rule Indirect Food Additives: Polymers EPA intends to reclassify eight inert ingredients from List 2, Potentially Toxic Inerts/High Priority for Testing to List 1 Inerts of Toxicological Concern. One of the criteria for being considered a List 1 inert ingredient is to be characterized by the NTP as an animal carcinogen in at least one species and sex.

March 08, 2002 -- 67 FR 10718
The EPA used data from the NTP Toxicology and Carcinogenesis Studies of 2-Benzyl-4-chlorophenol (TR-424), 2-Butoxyethanol (TR-484), Butyl benzyl Phthalate (TRs 213 & 458), Diethanolamine (TR-478), Ethylbenzene (TR-466), 1,2-Epoxybutane (TR-329), 2-Mercaptobenzothiazole (TR-332), and Nitromethane (TR-461) to support its reclassification of these inert ingredients to List 1. (TR-444) 100-41-4
106-88-7
149-30-4
120-32-1
85-68-7
111-42-2
75-52-5
111-76-2
Final Rule International Conference on Harmonisation; Draft Recommendations for the Revision of the Permitted Daily Exposures for Two Solvents,N-Methylpyrrolidone and Tetrahydrofuran. The EPA established tolerances for combined residues of the insecticide diflubenzuron and its metabolites 4-chlorophenylurea and 4-chloroaniline (PCA) in or on pear.

February 15, 2002 -- 67 FR 7085
Information from the NTP bioassay of p-Chloroaniline Hydrochloride, TR-351, was used to establish the tolerance of diflubenzuron and its metabolites 4-chlorophenylurea and 4-chloroaniline at .50 ppm in or on pears. 20265-96-7
Notice International Conference on Harmonisation; Draft Recommendations for the Revision of the Permitted Daily Exposures for Two Solvents,N-Methylpyrrolidone and Tetrahydrofuran. The EPA is proposing AEGLs for 8 chemicals to provide Federal, State, and local agencies with threshold short-term exposure to hazardous airborne chemicals.

February 15, 2002 -- 67 FR 7164
The EPA used data from the NTP Toxicology and Carcinogenesis Studies of Propylene Oxide (TR-267) in determining the proposed AEGL values for propylene oxide. 75-56-9
Final Rule National Advisory Committee for Acute Exposure Guidelines Levels (AEGLs) for Hazardous Substances; Proposed AEGL Values. The EPA is proposing AEGLs for 18 chemicals to provide Federal, State, and local agencies with threshold short-term exposure limits for the public to hazardous, airborne chemicals.

May 02, 2001 -- 66 FR 21940
The EPA used data from the NTP Toxicology and Carcinogenesis Studies of Tetrachloroethylene (TR-311) and Tetranitromethane (TR-386) in determining the proposed AEGL values for these two chemicals. 509-14-8
127-18-4
Final Rule Control of Air Pollution from New Motor Vehicles: Heavy-Duty Engine and Vehicle Standards and Highway Diesel Fuel Sulfur Control Requirements. The EPA is setting new diesel exhaust emission standards for heavy-duty highway engines to protect the public's health. Health studies indicate potential hazards that appear to be related to acute and chronic exposure.

January 18, 2001 -- 66 FR 5002
The EPA cited the NTP as an example of a governmental agency that has identified diesel exhaust particles as reasonably anticipated to be a human carcinogen.(Ninth Report on Carcinogens).
Final Rule Lead and Lead Compounds: Lowering of Reporting Thresholds The EPA is lowering the reporting thresholds for lead and lead compounds which are subject to reporting under section 313 of the Emergency Planning and Community Right-to-Know Act and section 6607 of the Pollution Prevention Act.

January 17, 2001 -- 66 FR 4500
Commenters contended that the Persistent Bioaccumulative Toxic Chemicals (PBT) rule framework was designed only for organic substances and is being incorrectly applied to metals. The EPA disagreed citing, as an example, the NTP's criteria for characterizing chemical carcinogens is the same for organic as well as inorganic substances to support its position that it is scientifically valid to establish generic criteria that are applicable to all substances. (8th Report on Carcinogens)
Final Rule Vinclozolin; Pesticide Tolerances The EPA has established tolerances for combined residues of vinclozolin and its metabolites containing the 3,5-dichloroaniline moiety in or on specific raw agricultural commodities.

July 18, 2000 -- 65 FR 44453
The EPA used data from the NTP's p-Chloroaniline bioassay (TR-351) to help assess the carcinogenicity for structurally related chloroanilines. 20265-96-7
Notice Diflubenzuron; Pesticide Tolerances The EPA has received a pesticide petition for establishing a tolerance for residues of diflubenzuron in or on the raw agricultural commodity rangeland grass at 6.0 ppm. P-Chloroaniline (PCA) is a metabolite of diflubenzuron.

April 05, 2000 -- 65 FR 17872
Information from the NTP bioassay of p-Chloroaniline Hydrochloride, TR-351, was used to determine that the dietary risk from diflubenzuron-derived PCA is below EPA's level of concern. 20265-96-7
Final Rule Notice of Filing a Pesticide Petition to Establish a Tolerance for Certain Pesticide Chemicals in or on Food. The FDA is amending the food additive regulations to provide for the safe use of ethylene-norbornene copolymers as articles or components of articles in contact with dry food. Although the additive itself has not been shown to cause cancer, it has been found to contain minute amounts of benzene, a carcinogenic impurity resulting from the manufacture of the additive.

January 21, 2000 -- 65 FR 3384
The FDA used data from the NTP Carcinogenicity Study of Benzene (TR-289), to estimate the upper-bound limit of lifetime human risk from exposure resulting from the use of the additive. And based on its estimates of worst case exposure, the FDA concluded that there is reasonable certainty that no harm from exposure to benzene would result from the proposed use of the additive. 71-43-2
Final Rule 1,3-Dichloropropene: Proposed Determination to Terminate Special Review The EPA proposed to terminate the Special Review of 1,3-Dichloropropene (1,3-D). The EPA has determined that the benefits associated with the continued use of 1,3-D under the recently revised terms and conditions of 1,3-D's reregistration outweigh the risks.

January 12, 2000 -- 65 FR 1869
The EPA classified 1,3-D as a probable, human carcinogen based on the review of data from carcinogenicity studies including the NTP Toxicology and Carcinogenesis Studies of Telone II (TR-269). 542-75-6

Food and Drug Administration (FDA)

Notice Type Title Summary of Notice NTP Information Cited CASRN
Notice Acrylamide in Food; Request for Comments and for Scientific Data and Information The Food and Drug Administration (FDA) is requesting comments and scientific data and information on acrylamide in food. Acrylamide is a chemical that can form in some foods during certain types of high-temperature cooking. FDA is seeking information on practices that manufacturers have used to reduce acrylamide in food and the reductions they have been able to achieve in acrylamide levels. FDA is considering issuing guidance for industry on reduction of acrylamide levels in food products.

August 26, 2009 -- 74 FR 43134
Under the sponsorship of the National Toxicology Program, FDAs National Center for Toxicological Research (NCTR) embarked in 2002 on a series of new toxicology assays for acrylamide. These studies were designed to address deficiencies in earlier carcinogenicity studies and to provide more reliable data on potential carcinogenic risk of acrylamide and other potential effects of acrylamide exposure. The work at NCTR includes long-term carcinogenicity bioassays of acrylamide and its metabolite glycidamide in mice and rats, as well as toxicokinetic, bioavailability, mutagenicity, and neurodevelopmental studies. NCTRs work also includes the development of a physiologically based pharmacokinetic model for acrylamide and glycidamide. (Acrylamide) (Glycidamide ) 79-06-1
5694-00-8
Proposed Skin Bleaching Drug Products For Over-the-Counter Human Use; Proposed Rule The Food and Drug Administration is issuing a notice of proposed rulemaking that would establish that over-the-counter (OTC) skin bleaching drug products are not generally recognized as safe and effective (GRASE) and are misbranded. FDA is also withdrawing the previous proposed rule on skin bleaching drug products for OTC human use, which was issued in the form of a tentative final monograph (TFM). FDA is issuing this proposed rule after considering new data and information on the safety of hydroquinone, the only active ingredient that had been proposed for inclusion in a monograph for these products. This proposal is part of FDA's ongoing review of OTC drug products. Further, upon issuance of a final rule, FDA intends to consider all skin bleaching drug products, whether currently marketed on a prescription or OTC basis, to be new drugs requiring an approved new drug application (NDA) for continued marketing.

August 29, 2006 -- 71 FR 51146
Toxicology and carcinogenesis studies on orally administered hydroquinone conducted under the support of the National Toxicology Program (NTP) (Refs. 1 and 2) have indicated "some evidence" of carcinogenicity in male and female rats and in female mice. FDA's Center for Drug Evaluation and Research (CDER) Carcinogenicity Assessment Committee (CAC) has evaluated the design, results, and NTP interpretation of these studies, and concurs with the NTP's assessment. (TR-366) 123-31-9 and 497-76-7
Final Rule Food Additives Permitted for Direct Addition to Food for Human Consumption; Synthetic Fatty Alcohols The Food and Drug Administration (FDA) is amending the food additive regulations to provide for the safe use of n-octanol (n-octyl alcohol) produced by a new manufacturing process, the hydrodimerization of 1,3-butadiene. This action is in response to a petition filed by Kuraray International Corp.

December 08, 2005 -- 70 FR 72906
The following references have been placed on display in the Division of Dockets Management (see ADDRESSES) and may be seen by interested persons between 9 a.m. and 4 p.m., Monday through Friday. "Toxicology and Carcinogenesis Studies of 1,3-Butadiene (CAS No. 106-99-0) in B6C3F1 Mice (Inhalation Studies)," National Toxicology Program. (TR-434) 106-99-0
Final Rule Food Additives Permitted for Direct Addition to Food for Human Consumption; Acacia (Gum Arabic) The Food and Drug Administration (FDA) is amending the food additive regulations to provide for the safe use of acacia (gum arabic) as a thickener, emulsifier, or stabilizer in alcoholic beverages at a maximum use level of 20 percent. This action is in response to a petition filed by Kerry, Inc.

February 17, 2005 -- 70 FR 8032
FDA conducted literature searches that updated the information that had formed the basis of the Select Committee report. The agency reviewed toxicological data from a 1982 National Toxicology Program (NTP) report of 2-year carcinogenicity feeding studies on acacia in F344 rats and B6C3F1 mice. The agency evaluated the carcinogenicity of acacia and concluded that F344 rats and B6C3F1 mice consuming diets containing up to 5-percent acacia for 2 years showed no increased incidences of tumors at any site. (TR-227) 9000-01-5
Notice Guidance for Industry: Labeling for Topically Applied Cosmetic Products Containing Alpha Hydroxy Acids as Ingredients; Availability The Food and Drug Administration (FDA) is announcing the availability of a guidance document entitled "Guidance for Industry: Labeling for Topically Applied Cosmetic Products Containing Alpha Hydroxy Acids as Ingredients." The guidance recommends content for a labeling statement for cosmetic products containing alpha hydroxy acids (AHAs) as ingredients.

January 10, 2005 -- 70 FR 1721
Publication of this guidance is an interim measure while FDA continues to review the data on the effects of AHA-containing products on skin sensitivity to UV radiation, including a photocarcinogenicity study by the National Toxicology Program's Center for Phototoxicology and recent studies published in peer-reviewed journals. FDA invites comments to continue to inform FDA of new studies when they become available. (TR-524) 79-14-1 and 69-72-7
Notice Furan in Food, Thermal Treatment; Request for Data and Information The FDA is requesting the submission of data and information on furan, a heat treatment related byproduct that has been detected in certain thermally treated foods.

May 10, 2004 -- 69 FR 25911
Results from the NTP bioassay on furan (TR-402) showed clear evidence of carcinogenic activity in both rats and mice. Cytotoxic and carcinogenic effects were seen at all doses, and a no adverse effect level was not identified. The FDA would like to acquire data on the effects of furan doses lower than those used in the NTP study. 110-00-9
Final Rule Final Rule Declaring Dietary Supplements Containing Ephedrine Alkaloids Adulterated Because They Present an Unreasonable Risk Final Rule Declaring Dietary Supplements Containing Ephedrine Alkaloids Adulterated Because They Present an Unreasonable Risk

February 11, 2004 -- 69 FR 6787
One comment objected that animal studies using ephedrine alkaloids to evaluate the safety of ephedrine alkaloids as dietary ingredients were not considered in the evaluation and cited the results of the National Toxicology Program's long term rodent studies on ephedrine (TR-307). 134-72-5
Notice International Conference on Harmonisation; Draft Recommendations for the Revision of the Permitted Daily Exposures for Two Solvents, N-Methylpyrrolidone and Tetrahydrofuran. The FDA is proposing a rule that would establish conditions under which over-the-counter drug products for the reduction or prevention of dental plaque and gingivitis are generally recognized as safe and effective and not misbranded.

May 29, 2003 -- 68 FR 32232
The NTP 13-week Stannous Chloride studies were used to develop the existing safety factor for potential exposure to Stannous salts from use of a dentifrice containing stannous fluoride. (TR-231) 7772-99-8
Final Rule New Animal Drugs: Phenylbutazone; Extralabel Animal Drug Use; Order of Prohibition The FDA is prohibiting the extralabel use of phenylbutazone animal and human drugs in female dairy cattle 20 months of age or older. The extralabel use presents a risk to the public health.

February 28, 2003 -- 68 FR 9528
The FDA has determined that the extralabel use of phenylbutazone presents a risk to the public health. The FDA's conclusion is based on available toxicology data including data from the NTP Toxicology and Carcinogenesis Studies of Phenylbutazone (TR-367) and the NTP genotoxicity tests. 50-33-9
Notice International Conference on Harmonisation; Draft Recommendations for the Revision of the Permitted Daily Exposures for Two Solvents, N-Methylpyrrolidone and Tetrahydrofuran. The Food and Drug Administration is announcing the availability of draft recommendations for the revision of the permitted daily exposures (PDE) for n-methylpyrrolidone and tetrahydrofuran.

February 12, 2002 -- 67 FR 6542
Based on data from NTP Carcinogenicity Studies of Tetrahydrofuran, (TR-475), the ICH Steering Committee recommended that tetrahydrofuran be moved from class 3 into class 2. 109-99-9
Final Rule Vinclozolin; Pesticide Tolerances The FDA is amending the food additive regulations to provide for the safe use of hydrogenated butadiene/acrylonitrile copolymers intended for contact with food in repeated use applications. Although the additive itself has not been shown to cause cancer, it has been found to contain residual amounts of acrylonitrile and butadiene, carcinogenic impurities resulting from the manufacture of the additive.

November 15, 2000 -- 65 FR 68888
The FDA used data from the NTP Carcinogenicity Study of 1,3-Butadiene, (TR-434), to estimate the upper-bound limit of lifetime human risk from exposure resulting from the use of the additive. And based on its estimates of worst case exposure, the FDA concluded that there is reasonable certainty that no harm from exposure to butadiene would result from the proposed use of the additive. 106-99-0

Mine Safety and Health Administration (MSHA)

Notice Type Title Summary of Notice NTP Information Cited CASRN
Final Rule Diesel Particulate Matter Exposure of Underground Metal and Nonmetal Miners This final rule revises the May 20, 2006 effective date of the diesel particulate matter (DPM) final concentration limit of 160 micrograms of total carbon (TC) per cubic meter of air (160TC ug/m3) promulgated in the 2001 final rule "Diesel Particulate Matter Exposure of Underground Metal and Nonmetal Miners," and published in the Federal Register on January 19, 2001 (66 FR 5706) and amended on September 19, 2005 (70 FR 55019).

May 18, 2006 -- 71 FR 28924
In the 10th edition of its Report on Carcinogens, the National Toxicology Program (NTP) of the National Institutes of Health formally retained its designation of diesel exhaust particulates as "reasonably anticipated to be a human carcinogen." (U.S. Dept. of Health and Human Services, 2002). (ROC)

Although many commenters agreed that the adverse health effects associated with miners' exposure to DPM warranted an exposure limit, commenters from trade associations and industry continued to challenge the conclusions of the 2001 risk assessment. Discussions addressing this issue were summarized in the 2001 risk assessment and the 2005 update. As referenced in this section, the U.S. Environmental Protection Agency, World Health Organization, and the National Toxicology Program regard DPM exposure as adversely affecting human health.
Proposed Asbestos Exposure Limit MSHA is proposing to revise their existing health standards for asbestos exposure at metal and nonmetal mines, surface coal mines, and surface areas of underground coal mines. The proposed rule would reduce the full-shift permissible exposure limit and the excursion limit for airborne asbestos fibers, and make several nonsubstantive changes to add clarity to the standard. Exposure to asbestos has been associated with lung and other cancers, mesotheliomas, and asbestosis. This proposed rule would help assure that fewer miners who work in an environment where asbestos is present would suffer material impairment of health or functional capacity over their working lifetime.

July 29, 2005 -- 70 FR 43950
There have been increasing numbers of studies on asbestos and its hazards over the past 40 years. These efforts encompass government, industry, and academia on a local, national, and international scale. Government agencies and scientific groups in the United States, such as the National Institute for Occupational Safety and Health (NIOSH), the Agency for Toxic Substances and Disease Registry (ATSDR), the American Conference of Governmental Industrial Hygienists (ACGIH), and the National Toxicology Program (NTP), have addressed issues involving carcinogens, such as asbestos. 1332-21-4
Final Rule Diesel Particulate Matter Exposure of Underground Metal and Nonmetal Miners In this final rule: MSHA revises the existing standards addressing diesel particulate matter (DPM) exposure in underground metal and nonmetal (M/NM) mines; changes the interim concentration limit measured by total carbon to a comparable permissible exposure limit measured by elemental carbon, which renders a more accurate DPM exposure measurement; increases flexibility of compliance for mine operators by requiring longstanding hierarchy of controls for its other exposure-based health standards at M/NM mines, but retains the prohibition on rotation of miners for compliance; requires MSHA to consider economic as well as technological feasibility in determining if operators qualify for an extension of time in which to meet the final DPM limit; deletes the requirement for a control plan; and makes conforming changes to existing provisions concerning compliance determinations, environmental monitoring and recordkeeping.

June 06, 2005 -- 70 FR 32868
Moyer, et al. review of NTP data from 90-day and 2-yr exposures of particulates and use of mouse inhalation model and the NTP 10th edition of the Report on Carcinogens are cited in the MSHA revision of existing standards addressing diesel particulate matter (DPM) exposure in underground metal and nonmetal (M/NM) mines. (ROC)
Proposed Diesel Particulate Matter Exposure of Underground Metal and Nonmetal Miners The Department of Labor is proposing revising the existing diesel particulate matter (DPM) interim concentration limit.

August 14, 2003 -- 68 FR 48668
A published review of the particulate inhalation studies conducted by the NTP was used to update the toxicological effects of DPM exposure.
Final Rule Diesel Particulate Matter Exposure of Underground Coal Miners The Department of Labor is establishing new health standards for underground coal mines that use equipment powered by diesel engines. High concentrations of diesel particulate matter (DPM) increases the risk of serious health hazards in underground mines.

January 19, 2001 -- 66 FR 5525
The NTP is listed as one of many scientific organizations and governmental agencies that has reviewed the available epidemiologic and toxicological evidence for carcinogenicity and has identified dpm as a probable human carcinogen. (9th Report on Carcinogens)

National Institute for Occupational Safety and Health (NIOSH)

Notice Type Title Summary of Notice NTP Information Cited CASRN
Notice Request for Information on 1-Bromopropane The National Institute for Occupational Safety and Health (NIOSH) of the Centers for Disease Control and Prevention (CDC) intends to evaluate the scientific data on the brominated organic solvent, 1-Bromopropane (1–BP, CAS # 106–94–5, also known as n-propyl bromide), and develop appropriate communication documents, such as a Current Intelligence Bulletin, Criteria Document and/or other informational products, and establish a Recommended Exposure Limit (REL) for 1–BP. NIOSH is requesting information on the following: (1) published and unpublished reports and findings from in vitro and in vivo toxicity studies with 1–BP, (2) information on possible health effects observed in workers exposed to 1–BP, (3) information on workplaces and products in which 1–BP can be found, (4) description of work tasks and scenarios with a potential for exposure to 1–BP, (5) workplace exposure data, and (6) information on control measures (e.g., engineering controls, work practices, personal protective equipment) that are being used in workplaces where potential exposures to 1–BP occur.

September 16, 2009 -- 74 FR 47593
The National Toxicology Program (NTP) estimated that approximately 8.2 million pounds (lbs) of 1–BP were used in the United States (U.S.) in 2002. Estimates of the number of workers exposed to 1–BP are unavailable due to limited exposure data and its relatively recent introduction into domestic commerce.  (1-Bromopropane 106-94-5

Occupational Safety and Health Administration (OSHA)

Notice Type Title Summary of Notice NTP Information Cited CASRN
Proposed Hazard Communication OSHA proposes to modify its existing Hazard Communication Standard (HCS) to conform with the United Nations’ (UN) Globally Harmonized System of Classification and Labeling of Chemicals (GHS). OSHA has preliminarily determined that the proposed modifications will improve the quality and consistency of information provided to employers and employees regarding chemical hazards and associated protective measures. The Agency anticipates this improved information will enhance the effectiveness of the HCS in ensuring that employees are apprised of the chemical hazards to which they may be exposed, and in reducing the incidence of chemical-related occupational illnesses and injuries.

September 30, 2009 -- 74 FR 50379
Since carcinogenicity is the most controversial and difficult health effect to address, OSHA considers chemicals found to be carcinogenic in the National Toxicology Program’s Report on Carcinogens, or in monographs published by the International Agency for Research on Cancer, to be carcinogens in addition to those regulated by OSHA as carcinogens.  (ROC) NA
Proposed Occupational Exposure to Diacetyl and Food Flavorings Containing Diacetyl OSHA is requesting data, information, and comment on issues related to occupational exposure to diacetyl and food flavorings containing diacetyl, including current employee exposures to diacetyl; the relationship between exposure to diacetyl and the development of adverse health effects; exposure assessment and monitoring methods; exposure control methods; employee training; medical surveillance for adverse health effects related to diacetyl exposure; and other pertinent subjects. In this notice, OSHA intends the term diacetyl and food flavorings containing diacetyl to encompass other constituents of food flavorings containing diacetyl. In addition to information on diacetyl, OSHA seeks information on acetoin, acetaldehyde, acetic acid, furfural, and other compounds present in food flavorings that may cause or contribute to flavoring-related lung disease. The Agency is also interested in and seeks information about diacetyl present in substances other than food flavorings (e.g., naturally occurring diacetyl or diacetyl in fragrances) as well as substitutes used in place of diacetyl (e.g., diacetyl trimer). The information received in response to this document will assist the Agency in developing a proposed standard addressing occupational exposure to diacetyl and food flavorings containing diacetyl.

January 21, 2009 -- 74 FR 3938
The National Toxicology Program has approved the nomination of BFV, diacetyl, and acetoin for longer term inhalation testing.  (Artificial Butter Flavoring Mixture) (2,3-Butanedione (Diacetyl)) (Acetoin) BUTTERFLAVMX
431-03-8
513-86-0
Final Rule Occupational Exposure to Hexavalent Chromium The Occupational Safety and Health Administration (OSHA) is amending the existing standard which limits occupational exposure to hexavalent chromium (Cr(VI)). OSHA has determined based upon the best evidence currently available that at the current permissible exposure limit (PEL) for Cr(VI), workers face a significant risk to material impairment of their health.

February 28, 2006 -- 71 FR 10100
The National Toxicology Program (NTP) conducted an extensive multigenerational reproductive assessment by continuous breeding where the chromate was administered in the diet. The assessment yielded negative results. Animal inhalation studies were also negative. Thus, it cannot be concluded that Cr(VI) is a reproductive toxin for normal working situations. (Hexavalent chromium) 18540-29-9
Notice Notice of Availability of the Regulatory Flexibility Act Review of the Occupational Health Standard for Ethylene Oxide The Occupational Safety and Health Administration (OSHA) has conducted a review of its Ethylene Oxide (EtO) Standard pursuant to section 610 of the Regulatory Flexibility Act and section 5 of Executive Order 12866 on Regulatory Planning and Review.

April 22, 2005 -- 70 FR 20807
There is a continued need for the rule. Workers exposed to EtO in a range of industries would continue to be at risk of cancer, genetic changes and other adverse health effects, without the standard. Since the standard was developed, the International Agency for Research on Cancer reclassified EtO as a known human carcinogen and the National Toxicology program reclassified EtO as a one "known to be a human carcinogen." (TR-326)(ROC)
75-21-8
Proposed Occupational Exposure to Hexavalent Chromium OSHA proposes to amend its existing standard for employee exposure to hexavalent chromium (Cr(VI)). The basis for issuance of this proposal is a preliminary determination by the Assistant Secretary that employees exposed to Cr(VI) face a significant risk to their health at the current permissible exposure limit and that promulgating this proposed standard will substantially reduce that risk.

October 04, 2004 -- 69 FR 59305
The NTP's First Annual Report on Carcinogens identified calcium chromate, chromium
chromate, strontium chromate, and zinc chromate as carcinogens in 1980.

The NTP conducted an extensive multigenerational reproductive assessment by continuous breeding where the chromate was administered in the diet. The assessment yielded negative results.
13765-19-0
7778-50-9
Final Rule Occupational Exposure to 4,4'Methylenedianiline (MDA) OSHA is promulgating new standards regulating exposure to MDA.

August 10, 2000 -- 57 FR 35630
The Committee determined that the tumors found in the NTP study did not result from exposure to MDA. (TR-248) 13552-44-8
Final Rule Air Contaminants OSHA notice providing index to Jan. 19, 1989 final rule and list of references relied upon for health effects evaluations in rule.

March 28, 2000 -- 54 FR 12792
NTP references cited include TR-306, TR-228, TR-263, TR-273, ;TR-311, TR-259, TR-251. 78-87-5
127-18-4
140-88-5
26471-62-5
75-09-2
75-35-4
79-01-6