Scientific Review of Nitromethane
Status: Listed in the Report on Carcinogens (RoC)
Primary Uses or Exposures: Most of the nitromethane produced in the United States (85% to 90%) is used in the synthesis of nitromethane derivatives used as pharmaceuticals, agricultural soil fumigants, and industrial antimicrobials. Nitromethane also is used as a fuel or fuel additive with methanol in racing cars, boats, and model engines. It formerly was used in the explosives industry as a component in a binary explosive formulation with ammonium nitrate and in shaped charges, and it was used as a chemical stabilizer to prevent decomposition of various halogenated hydrocarbons.
- Appendix A: IARC (2000). Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans. Nitromethane. In Some Industrial Chemicals. V 77. PP A-1 – A-15.
- Appendix B: NTP (1997). Toxicology and Carcinogenesis Studies of Nitromethane (CAS No. 75-52-5) in F344/N Rats and B6C3F1 Mice (Inhalation Studies). TR 461. PP B-1 – B-63.
Meetings and Minutes from Review Groups
- Review Group 1 Review Summary Document for Nitromethane (February 6, 2002)
- Review Group 2 Review Summary Document for Nitromethane (May 1, 2002)
- NTP Board of Scientific Counselors RoC Subcommittee Meeting (November 19–20, 2002)
Note on Accessibility: Persons with disabilities or using assistive technology may find some documents are not fully accessible. For assistance, contact Central Data Management or use our form and identify the documents/pages for which access is required. We will assist you in accessing the content of these files. NIEHS has helpful information on accessibility.