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Botanical Dietary Supplements Research Program: NTP Studies

NTP is conducting numerous studies in rodents to identify potential harm from short-term and long-term exposure to select botanical dietary supplements. These studies may provide toxicology data that can be used by the U.S. Food and Drug Administration, the National Institutes of Health, the public, and other stakeholders in evaluating the safety of certain supplements.

The tables below list ongoing and completed NTP studies on botanical dietary supplements with a link to the testing status page and any available reports or updates.

Ongoing NTP Studies
Botanical Dietary Supplement Commonly Used for Testing Status
Black cohosh Menstrual and menopausal symptoms Ongoing
Dong quai Menopausal symptoms Ongoing
Echinacea purpurea Common cold and other infections Ongoing
Evening primrose oil Eczema, menstrual and menopausal symptoms, breast pain Ongoing
Garcinia cambogia Appetite suppression and weight loss Ongoing
Ginkgo biloba Brain function and memory Ongoing
Gum guggul Lowering cholesterol, acne, and weight loss Ongoing
Usnea lichen Weight loss Ongoing
Valerian Insomnia and other sleep disorders Ongoing
Vinpocetine Memory enhancement Ongoing
Completed NTP Studies
Botanical Dietary Supplement Commonly Used for Study Status
Aloe vera Constipation and gastrointestinal disorders Completed
Technical Report 577
Ginkgo biloba Enhanced cognitive function and memory Completed
Technical Report 578
Ginseng General well-being, improved physical stamina, and concentration Completed
Technical Report 567
Goldenseal Skin disorders, ulcers, and fevers Completed
Technical Report 562
Green tea extract Mental alertness, digestive symptoms, headaches, and weight loss Completed
Technical Report 585
Kava kava Anxiety Completed
Technical Report 571
Milk thistle Liver cirrhosis, chronic hepatitis, and gall bladder disorders, in addition to other ailments Completed
Technical Report 565
Senna Constipation, irritable bowel syndrome, hemorrhoids, and weight loss Completed
Genetically Modified Model Report 15

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