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Medicines and Therapeutics Research: NTP Studies

NTP is conducting numerous studies in rodents to identify potential harm from short-term and long-term exposure to select medicines and therapeutics. These studies may provide toxicology data that can be used by the U.S. Food and Drug Administration, National Institutes of Health, public, and other stakeholders in evaluating the safety of certain medicines and therapeutics.

The tables below list ongoing and completed NTP studies on medicines and therapeutics with a link to the testing status page and any available reports or updates.

Ongoing NTP Studies

Medicine/Therapeutic

Commonly Used for

Testing Status

Azidothymidine (AZT) drug combinations, transplacental/carcinogenesis study

Treatment of HIV-AIDS

Ongoing

Azidothymidine (AZT) drug combinations, transplacental/neonatal study

Treatment of HIV-AIDS

Ongoing

2',3'-Dideoxycytidine

Treatment of HIV-AIDS

Ongoing

Efavirenz (EFV)

Treatment of HIV-AIDS

Ongoing

Efavirenz (EFV), Emtricitabine (FTC), Tenofovir Disoproxil Fumarate (TDF) combination 

Treatment of HIV-AIDS

Ongoing

Emtricitabine (FTC)

Treatment of HIV-AIDS

Ongoing

Ethinyl estradiol

Treatment of breast and prostate cancer

Ongoing

Fenofibrate

Reduce cholesterol and triglycerides

Ongoing

Hydroxyurea

Chemotherapeutic agent

Ongoing

Phenobarbital

Anticonvulsant, hypnotic, sedative

Ongoing

Simvastatin

Cholesterol-lowering medication that blocks the production of cholesterol

Ongoing

Tenofovir

Treatment of HIV-AIDS

Ongoing

Tenofovir Disoproxil Fumarte (TDF)

Treatment of HIV-AIDS

Ongoing

Completed NTP Studies

Medicine/Therapeutic

Commonly Used for

Testing Status

Acetaminophen

Pain relief

Completed

Technical Report 394

3’-Azido-3’-deoxythymidine (AZT)

Treatment of HIV-AIDS

Completed

Technical Report 569

3’-Azido-3’-deoxythymidine (AZT), transplacental carcinogenesis study

Treatment of HIV-AIDS

Completed

Technical Report 522

3’-Azido-3’-deoxythymidine and Isoiazid Combinations (AZT)

Treatment of HIV-AIDS

Completed

AIDS Toxicity Report 3

3’-Azido-3’-deoxythymidine (AZT), Lamivudine (3TC), Nevirapine (NVPT)

Treatment of HIV-AIDS

Completed

Genetically Modified Model Report 16

3’-Azido-3’-deoxythymidine (AZT) + Pyrazinamide combination

Treatment of HIV-AIDS

Completed

AIDS Toxicity Report 5

3’-Azido-3’-deoxythymidine (AZT) + Rifabutin

Treatment of HIV-AIDS

Completed

AIDS Toxicity Report 4

3’-Azido-3’-deoxythymidine (AZT) + Rifampin

Treatment of HIV-AIDS

Completed

AIDS Toxicity Report 6

3’-Azido-3’-deoxythymidine (AZT) + Trimethoprim/Sulfamethoxazole

Treatment of HIV-AIDS

Completed

AIDS Toxicity Report 2

Barium chloride dihydrate

Cardiac stimulant

Completed

Technical Report 432

Chloral hydrate

Sedative

Completed

Technical Report 502

Technical Report 503

Toxicity Report 59

Codeine

Pain relief and sedatives

Completed

Technical Report 455

5,5-Diphenylhydantoin

Antiepileptic and antiarrhythmic drug

Completed

Technical Report 404

Elmiron

Prevention of thrombosis and hyperlipidemia in foreign countries and for the treatment of interstitial cystitis in the us

Completed

Technical Report 512

Emodin

Laxative

Completed

Technical Report 493

Interferon

Treatment of HIV-AIDS

Completed

Technical Report 469

Methylene blue trihydrate

Antihemoglobinemic, cyanine poisoning antidote

Completed

Technical Report 540

Methylphenidate hydrochloride

Treatment of narcolepsy

Completed

Technical Report 439

Oxazepam

Sedative-hypnotic and antianxiety agent

Completed

Technical Report 468

Oxymetholone

Promote weight gain

Completed

Technical Report 485

Phenolphthalein

Laxative

Completed

Technical Report 465

Primidone

Management of partial grand mal and psychomotor seizures

Completed

Technical Report 476

Promethazine hydrochloride

Antihistamine

Completed

Technical Report 425

Pyrazinamide

Treatment of HIV-AIDS

Completed

AIDS Toxicity Report 1

Salicylazosulfapyridine

Treatment of ulcerative colitis and Crohn's disease

Completed

Technical Report 457

Scopolamine hydrobromide trihydrate

Sedative and treatment of motion sickness

Completed

Technical Report 445

1-trans-delta-9-Tetrahydrocannabinol

Topical use in hypertensive glaucomas

Completed

Technical Report 446

Triamterene

Diuretic

Completed

Technical Report 420

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