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NTP PACs Research: Studies and Results

PAC Mixtures Assessment Program

One of NTP’s study efforts is the Polycyclic Aromatic Compounds Mixtures Assessment Program, which aims to increase our understanding of the toxicity of PACs and PAC mixtures. In December 2012, NTP presented the research concept for PAC-MAP to the NTP Board of Scientific Counselors.

NTP will use a wide range of tests in cells and rodents to assess the toxicity of individual PACs and select PAC mixtures, and to identify potential health hazards. See the table for a list of the studies and their descriptions.

Table of Studies

Studies Description
High throughput screening Assays to derive information about cellular and molecular targets and use for predicting potential biological effects
Cytotoxicity and gene expression in diverse cell lines Cell-based assays to evaluate cytotoxicity and gene expression changes
Zebrafish developmental effects Short-term study to evaluate developmental effects in a vertebrate model system
Rat immunotoxicity (28-day) Assay to evaluate effects on the immune system
Rat toxicity and toxicogenomics (28-day) Assay to evaluate general toxicity and genomic changes

In addition, NTP will design experiments to assess whether the toxicity of a PAC mixture found in the environment can be predicted using information about the toxicity of individual PACs (component-based-mixture approach for risk assessment). NTP will also generate data on PAC mixtures that can be used to predict the toxicity of untested mixtures using a whole-mixture approach for risk assessment.

Results from PAC-MAP will contribute to addressing some of the knowledge gaps identified in the 2011 NIEHS workshop Advancing Research on Mixtures: New Perspectives and Approaches for Predicting Adverse Human Health Effects.