National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/757205

NTP Sulfolane Research: Studies

NTP is performing a set of studies to evaluate sulfolane toxicity, which includes potential carcinogenic effects, effects on the immune system, effects on development and reproduction, and other health impacts of exposure. The table describes each of the studies in more detail.

Table of Studies

Studies*
Testing Status Page
Description Species Exposure
28-day toxicity study Mice, rats, and guinea pigs are given a range of doses to determine if any of the animal species studied is more sensitive to sulfolane toxicity than the other species and to identify appropriate dosing levels for longer duration studies. Mice, rats, and guinea pigs 0 to 800 mg/kg/day via oral gavage
Absorption, distribution, metabolism, and excretion Mice and rats are given sulfolane to determine how a chemical moves within the body by different routes of exposure, including whether there are any differences between sexes or rodent species. Mice and rats Oral gavage, intravenous, and dermal (various doses)
Subchronic toxicity study Mice and rats from the two-year study will be assessed after three months of exposure to identify effects on development and reproduction, the immune system (rats only), and other endpoints. Mice and rats 0 to 1000 mg/L via drinking water
Chronic toxicity study This study will determine the effects of long-term exposure on rats and mice, including any potential carcinogenic effects. Mice and rats 0 to 1000 mg/L via drinking water
Immunotoxicity This study will determine the effects on the immune system in mice following three months of exposure by oral gavage and can be compared to results from the subchronic drinking water study. Mice 0 to 300 mg/kg/day via oral gavage

*See Descriptions of NTP Study Types for more information about NTP studies.

NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.