National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/21027

TDMS Study 96003-03 Pathology Tables

NTP Experiment-Test: 96003-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: 39 WEEKS                                          ALLYL BROMIDE                                       Date: 03/30/01
Route: GAVAGE                                                                                                     Time: 09:19:05

                                                          FINAL#1/MICE




       Facility:  BIORELIANCE

       Chemical CAS #:  106-95-6

       Lock Date:  10/18/00

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include 008    VEHICLE CONTROL
                               Include 009    0.5     MG/KG
                               Include 010    1 MG/KG
                               Include 011    2 MG/KG
                               Include 012    4 MG/KG
                               Include 013    8 MG/KG
                               Include 001    VEHICLE CONTROL
                               Include 002    0.5     MG/KG
                               Include 003    1 MG/KG
                               Include 004    2 MG/KG
                               Include 005    4 MG/KG
                               Include 006    8 MG/KG























a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 96003-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: 39 WEEKS                                          ALLYL BROMIDE                                       Date: 03/30/01    
Route: GAVAGE                                                                                                     Time: 09:19:05    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE       VEHICLE      0.5          1 MG/KG      2 MG/KG      4 MG/KG      8 MG/KG         
                                                   CONTROL      MG/KG                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          15           15           15           15           15           15           
  Early Deaths                                                                                                                      
    Dosing Accident                                    2                                                                            
    Moribund Sacrifice                                 2            3            4            6            1            3           
    Natural Death                                      2            2            3            1            3                        
  Survivors                                                                                                                         
    Terminal Sacrifice                                 9           10            8            8           11           12           
                                                                                                                                    
  Animals Examined Microscopically                    15           15           15           15           15           15           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (2)                                                                           
      Muscularis, Epithelium, Necrosis, Diffuse        1 (50%)                                                                      
      Muscularis, Periesophageal Tissue,                                                                                            
          Inflammation, Chronic Active, Focal          1 (50%)                                                                      
      Periesophageal Tissue, Foreign Body, Focal       1 (50%)                                                                      
   Intestine Small, Duodenum                          (13)         (14)         (11)         (12)         (13)         (15)         
      Serosa, Inflammation, Acute, Focal                                                                   1 (8%)                   
   Liver                                              (15)         (15)         (15)         (15)         (14)         (15)         
      Hematopoietic Cell Proliferation                 1 (7%)                    1 (7%)       1 (7%)                                
      Infiltration Cellular, Diffuse,                                                                                               
          Polymorphonuclear                                                                                1 (7%)       1 (7%)      
      Inflammation, Acute, Focal                                                 1 (7%)                    1 (7%)                   
      Inflammation, Chronic Active, Diffuse                                      1 (7%)                                             
      Necrosis, Chronic Active, Focal                                                                      1 (7%)                   
      Necrosis, Focal                                  2 (13%)      2 (13%)      3 (20%)      2 (13%)      1 (7%)       2 (13%)     
      Centrilobular, Vacuolization Cytoplasmic                                                                          1 (7%)      
      Hepatocyte, Degeneration, Focal                                            1 (7%)                                             
      Hepatocyte, Necrosis, Focal                      1 (7%)       1 (7%)       3 (20%)      5 (33%)      3 (21%)      4 (27%)     
      Hepatocyte, Vacuolization Cytoplasmic,                                                                                        
          Diffuse                                      4 (27%)      5 (33%)      3 (20%)                   4 (29%)      3 (20%)     
      Hepatocyte, Vacuolization Cytoplasmic, Focal     2 (13%)      2 (13%)      1 (7%)       4 (27%)      2 (14%)      3 (20%)     
      Hepatocyte, Periportal, Vacuolization                                                                                         
          Cytoplasmic                                                            1 (7%)                                 2 (13%)     
      Hepatocyte, Centrilobular, Vacuolization                                                                                      
          Cytoplasmic                                                                                                   1 (7%)      
      Serosa, Inflammation, Acute, Focal                                                                   1 (7%)                   
   Pancreas                                           (1)          (1)          (1)                       (3)                       
      Inflammation, Acute, Diffuse                                                                         1 (33%)                  
      Necrosis, Focal                                               1 (100%)                                                        
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    2                                                              
                                                                                                                                   
NTP Experiment-Test: 96003-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: 39 WEEKS                                          ALLYL BROMIDE                                       Date: 03/30/01    
Route: GAVAGE                                                                                                     Time: 09:19:05    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE       VEHICLE      0.5          1 MG/KG      2 MG/KG      4 MG/KG      8 MG/KG         
                                                   CONTROL      MG/KG                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Acinus, Atrophy, Diffuse                                                   1 (100%)                                           
   Stomach, Forestomach                               (14)         (15)         (12)         (13)         (14)         (15)         
      Muscularis, Serosa, Inflammation, Acute,                                                                                      
           Focal                                                                                           1 (7%)                   
   Stomach, Glandular                                 (13)         (14)         (11)         (13)         (13)         (15)         
      Serosa, Inflammation, Acute, Focal                                                                   1 (8%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (1)                                                                           
      Aorta, Inflammation, Chronic Active, Focal       1 (100%)                                                                     
   Heart                                                           (1)                       (1)                                    
      Atrium, Thrombosis, Focal                                                               1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (13)         (14)         (12)         (13)         (12)         (15)         
      Atrophy                                          4 (31%)      6 (43%)      9 (75%)      3 (23%)     11 (92%)      4 (27%)     
      Mineralization, Focal                                                                                             1 (7%)      
      Subcapsular, Hyperplasia, Focal                  2 (15%)      4 (29%)      3 (25%)      9 (69%)      5 (42%)      6 (40%)     
      Zona Reticularis, Hyperplasia, Diffuse                                                               1 (8%)                   
      Zona Reticularis, Infiltration Cellular,                                                                                      
           Focal, Lymphocyte                                                                               1 (8%)                   
      Zona Reticularis, Vacuolization Cytoplasmic,                                                                                  
           Diffuse                                     6 (46%)      8 (57%)      6 (50%)     10 (77%)      9 (75%)     12 (80%)     
      Zona Reticularis, Vacuolization Cytoplasmic,                                                                                  
           Focal                                       6 (46%)      4 (29%)      5 (42%)      2 (15%)      1 (8%)       3 (20%)     
   Thyroid Gland                                      (13)         (13)         (12)         (14)         (12)         (14)         
      Ectopic Thymus                                                             1 (8%)                    1 (8%)                   
      Follicle, Cyst, Focal                            1 (8%)                                              1 (8%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (13)         (15)         (14)         (14)         (13)         (15)         
      Angiectasis, Focal                                            1 (7%)                                                          
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    3                                                              
                                                                                                                                   
NTP Experiment-Test: 96003-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: 39 WEEKS                                          ALLYL BROMIDE                                       Date: 03/30/01    
Route: GAVAGE                                                                                                     Time: 09:19:05    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE       VEHICLE      0.5          1 MG/KG      2 MG/KG      4 MG/KG      8 MG/KG         
                                                   CONTROL      MG/KG                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Atrophy                                                       2 (13%)      2 (14%)                   1 (8%)                   
      Cyst                                                                       1 (7%)                    1 (8%)                   
      Cyst, Focal                                                                                                       1 (7%)      
      Degeneration                                     1 (8%)                    2 (14%)      1 (7%)       1 (8%)       1 (7%)      
      Inflammation, Acute, Diffuse                                                                         1 (8%)                   
      Inflammation, Chronic Active, Diffuse                                                                1 (8%)                   
      Inflammation, Diffuse                                                                                             1 (7%)      
      Bilateral, Inflammation, Chronic Active,                                                                                      
           Diffuse                                     1 (8%)                                                                       
      Bilateral, Periovarian Tissue, Cyst                                                                  1 (8%)                   
      Corpus Luteum, Inflammation, Chronic Active,                                                                                  
           Focal                                                                 1 (7%)                                             
      Periovarian Tissue, Inflammation, Acute,                                                                                      
           Focal                                                                                                        1 (7%)      
      Periovarian Tissue, Inflammation, Chronic                                                                                     
          Active, Diffuse                              1 (8%)                                                                       
      Periovarian Tissue, Inflammation, Chronic                                                                                     
          Active, Focal                                             1 (7%)                    1 (7%)                                
      Periovarian Tissue, Rete Ovarii,                                                                                              
          Inflammation, Acute, Focal                                             1 (7%)                    1 (8%)                   
   Uterus                                             (13)         (15)         (13)         (14)         (12)         (15)         
      Atrophy                                                                                              1 (8%)                   
      Hydrometra                                                    1 (7%)                    2 (14%)                               
      Inflammation, Acute, Diffuse                                  1 (7%)                                                          
      Inflammation, Acute, Focal                                                 1 (8%)                                             
      Inflammation, Chronic Active, Diffuse                                      1 (8%)                                             
      Endometrium, Hyperplasia, Cystic                11 (85%)     10 (67%)      8 (62%)      4 (29%)     10 (83%)     13 (87%)     
      Endometrium, Inflammation, Acute, Focal          1 (8%)                                                                       
      Serosa, Inflammation, Acute, Focal                                                                   1 (8%)                   
   Vagina                                                                       (1)                                                 
      Inflammation, Chronic Active, Diffuse                                      1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node                                                                                             (1)                       
      Iliac, Hyperplasia                                                                                   1 (100%)                 
      Renal, Hyperplasia                                                                                   1 (100%)                 
   Lymph Node, Mandibular                             (14)         (15)         (12)         (14)         (12)         (15)         
      Hyperplasia                                      2 (14%)      1 (7%)                                 2 (17%)      2 (13%)     
      Inflammation, Acute, Focal                                                 1 (8%)                                             
      Necrosis, Focal                                                                                                   1 (7%)      
   Lymph Node, Mesenteric                             (13)         (14)         (12)         (15)         (12)         (15)         
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    4                                                              
                                                                                                                                   
NTP Experiment-Test: 96003-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: 39 WEEKS                                          ALLYL BROMIDE                                       Date: 03/30/01    
Route: GAVAGE                                                                                                     Time: 09:19:05    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE       VEHICLE      0.5          1 MG/KG      2 MG/KG      4 MG/KG      8 MG/KG         
                                                   CONTROL      MG/KG                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Hyperplasia                                      1 (8%)                                                                       
   Lymph Node, Mediastinal                            (14)         (15)         (14)         (14)         (12)         (14)         
      Atrophy                                                       1 (7%)                                                          
      Hyperplasia                                                                1 (7%)                    1 (8%)                   
      Inflammation, Diffuse                                                                                             1 (7%)      
   Spleen                                             (15)         (14)         (15)         (15)         (13)         (15)         
      Hematopoietic Cell Proliferation                13 (87%)     11 (79%)     15 (100%)    13 (87%)     12 (92%)     14 (93%)     
      Pigmentation                                    10 (67%)     11 (79%)     10 (67%)     14 (93%)     11 (85%)     14 (93%)     
      Capsule, Inflammation, Acute, Focal                                                                  2 (15%)                  
      Lymphoid Follicle, Depletion Cellular            1 (7%)       1 (7%)                    1 (7%)                                
   Thymus                                             (13)         (13)         (12)         (13)         (11)         (15)         
      Atrophy, Diffuse                                 5 (38%)      3 (23%)                   2 (15%)                   1 (7%)      
      Atrophy, Focal                                                2 (15%)      1 (8%)       3 (23%)      2 (18%)      6 (40%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (1)                                                                           
      Dilatation, Focal                                1 (100%)                                                                     
   Skin                                               (15)         (15)         (15)         (15)         (14)         (15)         
      Dermis, Fibrosis, Focal                                                    1 (7%)                                             
      Dermis, Subcutaneous Tissue, Inflammation,                                                                                    
           Chronic Active, Diffuse                                               1 (7%)                                             
      Epidermis, Hyperplasia, Focal                                              1 (7%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (14)         (15)         (15)         (15)         (14)         (15)         
      Alveolus, Hemorrhage, Focal                                                             1 (7%)                    1 (7%)      
      Alveolus, Hyperplasia, Focal, Histiocytic                                  1 (7%)                                             
      Alveolus, Inflammation, Chronic, Focal                                                               1 (7%)                   
      Arteriole, Necrosis, Focal                                                 1 (7%)                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    5                                                              
                                                                                                                                   
NTP Experiment-Test: 96003-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: 39 WEEKS                                          ALLYL BROMIDE                                       Date: 03/30/01    
Route: GAVAGE                                                                                                     Time: 09:19:05    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE       VEHICLE      0.5          1 MG/KG      2 MG/KG      4 MG/KG      8 MG/KG         
                                                   CONTROL      MG/KG                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Mediastinum, Inflammation, Acute, Focal          1 (7%)                                              1 (7%)                   
      Perivascular, Infiltration Cellular,                                                                                          
          Lymphocyte                                                             1 (7%)                    1 (7%)       1 (7%)      
      Serosa, Mediastinum, Inflammation, Chronic                                                                                    
          Active, Focal                                             1 (7%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (15)         (14)         (14)         (15)         (13)         (15)         
      Infiltration Cellular, Focal, Lymphocyte                                                                          1 (7%)      
      Inflammation, Chronic Active, Focal                                        1 (7%)                    1 (8%)                   
      Necrosis, Focal                                                            1 (7%)                                             
      Bilateral, Inflammation, Acute, Focal            1 (7%)                                                           1 (7%)      
      Bilateral, Nephropathy, Diffuse                  1 (7%)                                                                       
      Capsule, Inflammation, Acute, Focal                                        1 (7%)                                             
      Cortex, Inflammation, Acute, Focal                            1 (7%)                                                          
      Cortex, Pelvis, Inflammation, Chronic Active,                                                                                 
           Focal                                       1 (7%)                                                                       
      Papilla, Inflammation, Acute, Focal                                                     1 (7%)                                
      Renal Tubule, Degeneration, Focal                             1 (7%)                                                          
      Renal Tubule, Dilatation, Diffuse                1 (7%)       1 (7%)       1 (7%)                                             
      Renal Tubule, Dilatation, Focal                                                         2 (13%)      1 (8%)                   
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    6                                                              
                                                                                                                                   
NTP Experiment-Test: 96003-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: 39 WEEKS                                          ALLYL BROMIDE                                       Date: 03/30/01    
Route: GAVAGE                                                                                                     Time: 09:19:05    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         MICE:TGAC (FVB/N) HEMIZYGOUS MALE         VEHICLE      0.5          1 MG/KG      2 MG/KG      4 MG/KG      8 MG/KG         
                                                   CONTROL      MG/KG                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          15           15           15           15           15           15           
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 2            2            3            2            4            1           
    Natural Death                                      1            3            3                         4            2           
    Dosing Accident                                                 1                         1            1            1           
  Survivors                                                                                                                         
    Terminal Sacrifice                                12            9            9           12            6           11           
                                                                                                                                    
  Animals Examined Microscopically                    15           15           15           15           15           15           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                                       (1)                       (1)          (1)          (1)          
      Muscularis, Periesophageal Tissue,                                                                                            
          Inflammation, Chronic Active, Diffuse                                               1 (100%)                              
      Periesophageal Tissue, Inflammation, Chronic                                                                                  
          Active, Diffuse                                                                                  1 (100%)     1 (100%)    
      Periesophageal Tissue, Inflammation, Chronic                                                                                  
          Active, Focal                                             1 (100%)                                                        
   Liver                                              (14)         (15)         (14)         (15)         (14)         (15)         
      Necrosis, Focal                                               1 (7%)                                              1 (7%)      
      Hepatocyte, Necrosis, Focal                      2 (14%)      3 (20%)      5 (36%)                   2 (14%)                  
      Hepatocyte, Vacuolization Cytoplasmic,                                                                                        
          Diffuse                                                   1 (7%)                                                          
      Hepatocyte, Vacuolization Cytoplasmic, Focal                                            1 (7%)       1 (7%)       2 (13%)     
      Hepatocyte, Centrilobular, Hypertrophy           1 (7%)                                                                       
      Hepatocyte, Centrilobular, Vacuolization                                                                                      
          Cytoplasmic                                  2 (14%)                   2 (14%)                                1 (7%)      
      Serosa, Inflammation, Chronic Active, Focal                   1 (7%)                                                          
      Sinusoid, Inflammation, Focal                                              1 (7%)                                             
   Mesentery                                          (1)          (1)                       (2)                                    
      Fat, Necrosis, Focal                             1 (100%)     1 (100%)                  2 (100%)                              
   Pancreas                                                                                                            (1)          
      Acinus, Atrophy, Diffuse                                                                                          1 (100%)    
   Salivary Glands                                                 (1)          (1)          (1)                                    
      Necrosis, Focal                                                            1 (100%)                                           
   Tooth                                              (5)          (5)          (4)          (3)          (6)          (4)          
      Peridontal Tissue, Inflammation, Chronic                                                                                      
          Active, Focal                                                                                                 1 (25%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                             Page    7                                                              
                                                                                                                                   
NTP Experiment-Test: 96003-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: 39 WEEKS                                          ALLYL BROMIDE                                       Date: 03/30/01    
Route: GAVAGE                                                                                                     Time: 09:19:05    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         MICE:TGAC (FVB/N) HEMIZYGOUS MALE         VEHICLE      0.5          1 MG/KG      2 MG/KG      4 MG/KG      8 MG/KG         
                                                   CONTROL      MG/KG                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (15)         (14)         (14)         (14)         (12)         (14)         
      Atrophy                                         15 (100%)    13 (93%)     14 (100%)    14 (100%)    10 (83%)     12 (86%)     
      Degeneration, Focal                                                        1 (7%)                                             
      Hypertrophy, Focal                              13 (87%)     10 (71%)      9 (64%)     11 (79%)     10 (83%)     11 (79%)     
      Subcapsular, Hyperplasia, Focal                                                         1 (7%)                                
      Zona Reticularis, Vacuolization Cytoplasmic,                                                                                  
           Focal                                       1 (7%)                                 1 (7%)       1 (8%)       1 (7%)      
   Thyroid Gland                                      (15)         (13)         (14)         (15)         (9)          (14)         
      Inflammation, Chronic Active, Focal                           1 (8%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                                                   (1)                                    (1)          
      Fat, Necrosis, Focal                                                                                              1 (100%)    
      Mediastinum, Inflammation, Chronic Active,                                                                                    
           Focal                                                                 1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Preputial Gland                                    (1)          (2)          (2)          (1)          (4)          (2)          
      Ectasia                                          1 (100%)     1 (50%)      2 (100%)     1 (100%)     4 (100%)     2 (100%)    
      Inflammation, Chronic Active, Focal                           1 (50%)                                                         
   Seminal Vesicle                                                                           (1)                       (1)          
      Dilatation                                                                              1 (100%)                              
      Bilateral, Dilatation                                                                                             1 (100%)    
   Testes                                             (15)         (15)         (15)         (15)         (14)         (14)         
      Germinal Epithelium, Degeneration, Diffuse                                              1 (7%)                                
      Germinal Epithelium, Degeneration, Focal         1 (7%)                    5 (33%)      1 (7%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node, Mandibular                             (15)         (13)         (14)         (15)         (13)         (15)         
      Hyperplasia                                      1 (7%)       1 (8%)       2 (14%)                   3 (23%)      1 (7%)      
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    8                                                              
                                                                                                                                   
NTP Experiment-Test: 96003-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: 39 WEEKS                                          ALLYL BROMIDE                                       Date: 03/30/01    
Route: GAVAGE                                                                                                     Time: 09:19:05    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         MICE:TGAC (FVB/N) HEMIZYGOUS MALE         VEHICLE      0.5          1 MG/KG      2 MG/KG      4 MG/KG      8 MG/KG         
                                                   CONTROL      MG/KG                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Hyperplasia, Histiocytic                                      1 (8%)                                                          
   Lymph Node, Mesenteric                             (14)         (14)         (14)         (15)         (12)         (14)         
      Hyperplasia                                                   1 (7%)                                                          
      Inflammation, Chronic Active, Focal                                        1 (7%)                                             
   Lymph Node, Mediastinal                            (14)         (13)         (14)         (15)         (10)         (14)         
      Hyperplasia                                                   1 (8%)       1 (7%)                                             
   Spleen                                             (15)         (14)         (14)         (15)         (14)         (15)         
      Congestion                                                    1 (7%)                                 1 (7%)                   
      Hematopoietic Cell Proliferation                14 (93%)     14 (100%)    13 (93%)     15 (100%)    12 (86%)     13 (87%)     
      Inflammation, Chronic Active, Focal                                        1 (7%)                                             
      Pigmentation                                     8 (53%)     10 (71%)      9 (64%)     12 (80%)      6 (43%)     11 (73%)     
      Lymphoid Follicle, Depletion Cellular            1 (7%)       1 (7%)                    1 (7%)       1 (7%)                   
   Thymus                                             (15)         (13)         (12)         (15)         (10)         (13)         
      Atrophy, Diffuse                                 3 (20%)      3 (23%)      2 (17%)      2 (13%)      3 (30%)      1 (8%)      
      Atrophy, Focal                                   1 (7%)       2 (15%)      1 (8%)       4 (27%)      1 (10%)      1 (8%)      
      Hyperplasia                                                                2 (17%)                                            
      Hyperplasia, Focal                                                                                   1 (10%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (15)         (15)         (15)         (15)         (14)         (15)         
      Hyperkeratosis, Focal                                                                                             1 (7%)      
      Dermis, Inflammation, Chronic Active, Focal                                                                       1 (7%)      
      Epidermis, Hyperplasia, Focal                    1 (7%)                                                           2 (13%)     
      Subcutaneous Tissue, Inflammation, Chronic                                                                                    
          Active, Focal                                             1 (7%)                    1 (7%)                                
      Subcutaneous Tissue, Necrosis, Focal                                       1 (7%)                                 1 (7%)      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (15)         (15)         (14)         (15)         (14)         (15)         
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    9                                                              
                                                                                                                                   
NTP Experiment-Test: 96003-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: 39 WEEKS                                          ALLYL BROMIDE                                       Date: 03/30/01    
Route: GAVAGE                                                                                                     Time: 09:19:05    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         MICE:TGAC (FVB/N) HEMIZYGOUS MALE         VEHICLE      0.5          1 MG/KG      2 MG/KG      4 MG/KG      8 MG/KG         
                                                   CONTROL      MG/KG                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Inflammation, Chronic Active, Focal                                        1 (7%)                                             
      Alveolar Epithelium, Hyperplasia, Focal                       1 (7%)                                                          
      Alveolus, Hemorrhage, Focal                                                1 (7%)       1 (7%)                    1 (7%)      
      Arteriole, Artery, Inflammation, Chronic                                                                                      
          Active, Focal                                                                                    2 (14%)                  
      Arteriole, Capillary, Perivascular,                                                                                           
          Inflammation, Acute                                       1 (7%)                                                          
      Mediastinum, Inflammation, Chronic Active,                                                                                    
           Diffuse                                                                                                      1 (7%)      
      Perivascular, Infiltration Cellular, Focal,                                                                                   
           Lymphocyte                                               1 (7%)       1 (7%)                                             
      Perivascular, Infiltration Cellular,                                                                                          
          Lymphocyte                                   1 (7%)                                              1 (7%)       1 (7%)      
      Serosa, Mediastinum, Inflammation, Chronic                                                                                    
          Active, Diffuse                                                        1 (7%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (1)                                                 (1)                       
      Retina, Atrophy                                  1 (100%)                                            1 (100%)                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (15)         (14)         (14)         (15)         (14)         (14)         
      Inflammation, Acute, Focal                                    1 (7%)                                                          
      Inflammation, Chronic Active, Focal                                        1 (7%)                                             
      Bilateral, Cortex, Inflammation, Acute, Focal                                                        1 (7%)                   
      Capsule, Cortex, Inflammation, Chronic                                                                                        
          Active, Focal                                             1 (7%)                                                          
      Cortex, Inflammation, Acute, Focal                                                                   2 (14%)                  
      Renal Tubule, Degeneration, Focal                                                                    2 (14%)                  
      Renal Tubule, Dilatation, Diffuse                                          1 (7%)                    1 (7%)                   
      Renal Tubule, Dilatation, Focal                  1 (7%)       1 (7%)       1 (7%)       1 (7%)                                
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   10                                                              
                                                                                                                                   
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                             ----------              END OF REPORT             ----------                                           
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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.