TDMS Study 96003-03 Pathology Tables
NTP Experiment-Test: 96003-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01 Route: GAVAGE Time: 09:19:14 FINAL#1/MICE Facility: BIORELIANCE Chemical CAS #: 106-95-6 Lock Date: 10/18/00 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include 008 VEHICLE CONTROL Include 009 0.5 MG/KG Include 010 1 MG/KG Include 011 2 MG/KG Include 012 4 MG/KG Include 013 8 MG/KG Include 001 VEHICLE CONTROL Include 002 0.5 MG/KG Include 003 1 MG/KG Include 004 2 MG/KG Include 005 4 MG/KG Include 006 8 MG/KG Page 1 NTP Experiment-Test: 96003-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01 Route: GAVAGE Time: 09:19:14 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 1| 2| 2| 2| | | DAY ON TEST | 7| 7| 7| 7| 1| 7| 5| 1| 2| 7| 7| 5| 7| 7| 6| | | | 5| 5| 5| 5| 7| 5| 4| 4| 9| 5| 5| 1| 5| 5| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | VEHICLE | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L | CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + | 2 | Muscularis, Epithelium, Necrosis, | | | Diffuse | 4 | 1 4.0| Muscularis, Periesophageal Tissue, | | | Inflammation, Chronic Active, | | | Focal | 3 | 1 3.0| Periesophageal Tissue, Foreign Body, | | | Focal | 3 | 1 3.0| |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + A + + + + + A | 13 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + A | 14 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + A + + + + + A | 13 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + A + + + + + A | 13 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | I + + + A + + + A + + + + + A | 11 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + A + + + + + A | 13 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + | 15 | Hematopoietic Cell Proliferation | 1 | 1 1.0| Necrosis, Focal | 2 2 | 2 2.0| Hepatocyte, Necrosis, Focal | 1 | 1 1.0| Hepatocyte, Vacuolization | | | Cytoplasmic, Diffuse | 3 1 2 2 | 4 2.0| Hepatocyte, Vacuolization | | | Cytoplasmic, Focal | 1 1 | 2 1.0| |__________________________________________________________________________|____________| Pancreas | + | 1 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + A + + + + + + | 14 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 2 NTP Experiment-Test: 96003-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01 Route: GAVAGE Time: 09:19:14 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 1| 2| 2| 2| | | DAY ON TEST | 7| 7| 7| 7| 1| 7| 5| 1| 2| 7| 7| 5| 7| 7| 6| | | | 5| 5| 5| 5| 7| 5| 4| 4| 9| 5| 5| 1| 5| 5| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | VEHICLE | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L | CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + A + + + + + A | 13 | |__________________________________________________________________________|____________| Tooth | + + | 2 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | + | 1 | Aorta, Inflammation, Chronic Active, | | | Focal | 4 | 1 4.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + A + + + + + A | 13 | Atrophy | 1 1 2 2 | 4 1.5| Subcapsular, Hyperplasia, Focal | 1 1 | 2 1.0| Zona Reticularis, Vacuolization | | | Cytoplasmic, Diffuse | 2 2 4 3 4 3 | 6 3.0| Zona Reticularis, Vacuolization | | | Cytoplasmic, Focal | 2 1 1 2 1 1 | 6 1.3| |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + A + + + + + A | 13 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + M + A + + M + + A | 11 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + A + + + + + A | 13 | Follicle, Cyst, Focal | 1 | 1 1.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Ovary | + + + + + + + + A + + + + + A | 13 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 3 NTP Experiment-Test: 96003-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01 Route: GAVAGE Time: 09:19:14 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 1| 2| 2| 2| | | DAY ON TEST | 7| 7| 7| 7| 1| 7| 5| 1| 2| 7| 7| 5| 7| 7| 6| | | | 5| 5| 5| 5| 7| 5| 4| 4| 9| 5| 5| 1| 5| 5| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | VEHICLE | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L | CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| GENITAL SYSTEM - cont | | | Degeneration | 2 | 1 2.0| Bilateral, Inflammation, Chronic | | | Active, Diffuse | 4 | 1 4.0| Periovarian Tissue, Inflammation, | | | Chronic Active, Diffuse | 3 | 1 3.0| |__________________________________________________________________________|____________| Uterus | + + + + + + + + A + + + + + A | 13 | Endometrium, Hyperplasia, Cystic | 1 2 2 2 3 2 3 3 1 2 3 | 11 2.2| Endometrium, Inflammation, Acute, | | | Focal | 4 | 1 4.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + A | 14 | Hyperplasia | 2 2 | 2 2.0| |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + A + + + + + A | 13 | Hyperplasia | 1 | 1 1.0| |__________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + + + + + + + + + + A | 14 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + | 15 | Hematopoietic Cell Proliferation | 2 2 2 3 1 2 3 3 2 2 2 2 2 | 13 2.2| Pigmentation | 1 1 1 1 1 1 1 1 1 1 | 10 1.0| Lymphoid Follicle, Depletion Cellular| 2 | 1 2.0| |__________________________________________________________________________|____________| Thymus | + + + + + + + + A + + + + + A | 13 | Atrophy, Diffuse | 2 4 4 4 3 | 5 3.4| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + | 1 | Dilatation, Focal | 4 | 1 4.0| |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 4 NTP Experiment-Test: 96003-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01 Route: GAVAGE Time: 09:19:14 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 1| 2| 2| 2| | | DAY ON TEST | 7| 7| 7| 7| 1| 7| 5| 1| 2| 7| 7| 5| 7| 7| 6| | | | 5| 5| 5| 5| 7| 5| 4| 4| 9| 5| 5| 1| 5| 5| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | VEHICLE | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L | CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| INTEGUMENTARY SYSTEM - cont | | | Skin | + + + + + + + + + + + + + + + | 15 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + A + + + + + + | 14 | Mediastinum, Inflammation, Acute, | | | Focal | 4 | 1 4.0| |__________________________________________________________________________|____________| Trachea | M | | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + | 15 | Bilateral, Inflammation, Acute, Focal| 4 | 1 4.0| Bilateral, Nephropathy, Diffuse | 4 | 1 4.0| Cortex, Pelvis, Inflammation, | | | Chronic Active, Focal | 3 | 1 3.0| Renal Tubule, Dilatation, Diffuse | 2 | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 5 NTP Experiment-Test: 96003-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01 Route: GAVAGE Time: 09:19:14 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 1| 2| 2| 2| | | DAY ON TEST | 7| 7| 7| 7| 7| 0| 7| 1| 4| 7| 1| 6| 7| 7| 7| | | | 5| 5| 5| 5| 5| 0| 5| 8| 7| 5| 9| 2| 5| 5| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 0.5 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| | L | MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + A + + + + | 14 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + A + + + + | 14 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + A + + + + | 14 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + A + + + + | 14 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + A + + + + | 14 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + A + + + + | 14 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + | 15 | Necrosis, Focal | 2 1 | 2 1.5| Hepatocyte, Necrosis, Focal | 1 | 1 1.0| Hepatocyte, Vacuolization | | | Cytoplasmic, Diffuse | 2 2 2 2 3 | 5 2.2| Hepatocyte, Vacuolization | | | Cytoplasmic, Focal | 2 1 | 2 1.5| |__________________________________________________________________________|____________| Pancreas | + | 1 | Necrosis, Focal | 3 | 1 3.0| |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + A + + + + | 14 | |__________________________________________________________________________|____________| Tooth | + + + | 3 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Heart | + | 1 | _____________________________________________________________________________________________________________________| | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 6 NTP Experiment-Test: 96003-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01 Route: GAVAGE Time: 09:19:14 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 1| 2| 2| 2| | | DAY ON TEST | 7| 7| 7| 7| 7| 0| 7| 1| 4| 7| 1| 6| 7| 7| 7| | | | 5| 5| 5| 5| 5| 0| 5| 8| 7| 5| 9| 2| 5| 5| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 0.5 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| | L | MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + A + + + | 14 | Atrophy | 2 1 2 1 2 2 | 6 1.7| Subcapsular, Hyperplasia, Focal | 1 2 1 1 | 4 1.3| Zona Reticularis, Vacuolization | | | Cytoplasmic, Diffuse | 3 3 3 3 3 3 2 3 | 8 2.9| Zona Reticularis, Vacuolization | | | Cytoplasmic, Focal | 2 1 1 1 | 4 1.3| |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + A + + + | 14 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + I + + + + | 14 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + A A + + + | 13 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + | 15 | Angiectasis, Focal | 1 | 1 1.0| Atrophy | 2 2 | 2 2.0| Periovarian Tissue, Inflammation, | | | Chronic Active, Focal | 1 | 1 1.0| |__________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + | 15 | Hydrometra | 1 | 1 1.0| Inflammation, Acute, Diffuse | 4 | 1 4.0| Endometrium, Hyperplasia, Cystic | 2 2 1 2 3 1 3 2 1 1 | 10 1.8| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + | 15 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 7 NTP Experiment-Test: 96003-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01 Route: GAVAGE Time: 09:19:14 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 1| 2| 2| 2| | | DAY ON TEST | 7| 7| 7| 7| 7| 0| 7| 1| 4| 7| 1| 6| 7| 7| 7| | | | 5| 5| 5| 5| 5| 0| 5| 8| 7| 5| 9| 2| 5| 5| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 0.5 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| | L | MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | Hyperplasia | 2 | 1 2.0| |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + A + + + + | 14 | |__________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + + + + + + + + + + + | 15 | Atrophy | 3 | 1 3.0| |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + A + + + + | 14 | Hematopoietic Cell Proliferation | 2 1 3 2 2 2 2 2 2 2 2 | 11 2.0| Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 | 11 1.0| Lymphoid Follicle, Depletion Cellular| 4 | 1 4.0| |__________________________________________________________________________|____________| Thymus | + + + + + I + + + + A + + + + | 13 | Atrophy, Diffuse | 3 3 3 | 3 3.0| Atrophy, Focal | 2 1 | 2 1.5| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + | 15 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + | 15 | Serosa, Mediastinum, Inflammation, | | | Chronic Active, Focal | 4 | 1 4.0| _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | None | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 8 NTP Experiment-Test: 96003-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01 Route: GAVAGE Time: 09:19:14 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 1| 2| 2| 2| | | DAY ON TEST | 7| 7| 7| 7| 7| 0| 7| 1| 4| 7| 1| 6| 7| 7| 7| | | | 5| 5| 5| 5| 5| 0| 5| 8| 7| 5| 9| 2| 5| 5| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 0.5 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| | L | MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | | _____________________________________________________________________________________________________________________|____________| URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + A + + + | 14 | Cortex, Inflammation, Acute, Focal | 3 | 1 3.0| Renal Tubule, Degeneration, Focal | 1 | 1 1.0| Renal Tubule, Dilatation, Diffuse | 3 | 1 3.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 9 NTP Experiment-Test: 96003-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01 Route: GAVAGE Time: 09:19:14 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 1| 2| 1| 2| 1| 2| 2| 2| 2| 2| 1| 1| | | DAY ON TEST | 4| 7| 7| 9| 7| 4| 7| 0| 7| 7| 7| 7| 3| 9| 6| | | | 6| 5| 5| 4| 5| 9| 5| 2| 5| 5| 5| 5| 4| 3| 4| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 1 MG/KG | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + A + + + + + + + + + A + | 13 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + A + + + + + + + + + A + | 13 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + A + + + + + + + + + A A | 12 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + A + + + + + + + + A A A | 11 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + A + + + + + + + + A A A | 11 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + A + + + + + + + + A A + | 12 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + | 15 | Hematopoietic Cell Proliferation | 1 | 1 1.0| Inflammation, Acute, Focal | 1 | 1 1.0| Inflammation, Chronic Active, Diffuse| 4 | 1 4.0| Necrosis, Focal | 3 3 2 | 3 2.7| Hepatocyte, Degeneration, Focal | 2 | 1 2.0| Hepatocyte, Necrosis, Focal | 1 1 1 | 3 1.0| Hepatocyte, Vacuolization | | | Cytoplasmic, Diffuse | 3 1 3 | 3 2.3| Hepatocyte, Vacuolization | | | Cytoplasmic, Focal | 1 | 1 1.0| Hepatocyte, Periportal, | | | Vacuolization Cytoplasmic | 2 | 1 2.0| |__________________________________________________________________________|____________| Pancreas | + | 1 | Acinus, Atrophy, Diffuse | 4 | 1 4.0| |__________________________________________________________________________|____________| Salivary Glands | + + + | 3 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + A + + + + + + + + + A A | 12 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 10 NTP Experiment-Test: 96003-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01 Route: GAVAGE Time: 09:19:14 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 1| 2| 1| 2| 1| 2| 2| 2| 2| 2| 1| 1| | | DAY ON TEST | 4| 7| 7| 9| 7| 4| 7| 0| 7| 7| 7| 7| 3| 9| 6| | | | 6| 5| 5| 4| 5| 9| 5| 2| 5| 5| 5| 5| 4| 3| 4| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 1 MG/KG | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | Stomach, Glandular | + + + A + + + + + + + + A A A | 11 | |__________________________________________________________________________|____________| Tooth | + + + + + + | 6 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + A + + + + + + + + + A A | 12 | Atrophy | 2 1 2 1 2 2 2 1 2 | 9 1.7| Subcapsular, Hyperplasia, Focal | 1 1 1 | 3 1.0| Zona Reticularis, Vacuolization | | | Cytoplasmic, Diffuse | 2 2 3 3 3 3 | 6 2.7| Zona Reticularis, Vacuolization | | | Cytoplasmic, Focal | 2 2 1 1 1 | 5 1.4| |__________________________________________________________________________|____________| Adrenal Medulla | + + + A + + + + + + + + + A A | 12 | |__________________________________________________________________________|____________| Pituitary Gland | + + + I + + + + + + + + + + + | 14 | |__________________________________________________________________________|____________| Thyroid Gland | + + + M + + + + + + + + A A + | 12 | Ectopic Thymus | 1 | 1 1.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + A + + | 14 | Atrophy | 2 3 | 2 2.5| Cyst | 4 | 1 4.0| Degeneration | 2 1 | 2 1.5| Corpus Luteum, Inflammation, Chronic | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 11 NTP Experiment-Test: 96003-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01 Route: GAVAGE Time: 09:19:14 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 1| 2| 1| 2| 1| 2| 2| 2| 2| 2| 1| 1| | | DAY ON TEST | 4| 7| 7| 9| 7| 4| 7| 0| 7| 7| 7| 7| 3| 9| 6| | | | 6| 5| 5| 4| 5| 9| 5| 2| 5| 5| 5| 5| 4| 3| 4| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 1 MG/KG | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| GENITAL SYSTEM - cont | | | Active, Focal | 4 | 1 4.0| Periovarian Tissue, Rete Ovarii, | | | Inflammation, Acute, Focal | 4 | 1 4.0| |__________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + A A + | 13 | Inflammation, Acute, Focal | 2 | 1 2.0| Inflammation, Chronic Active, Diffuse| 4 | 1 4.0| Endometrium, Hyperplasia, Cystic | 1 2 3 2 1 1 3 2 | 8 1.9| |__________________________________________________________________________|____________| Vagina | + | 1 | Inflammation, Chronic Active, Diffuse| 4 | 1 4.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + M + + + + + A M | 12 | Inflammation, Acute, Focal | 1 | 1 1.0| |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + A + + + + + + + + A A + | 12 | |__________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + + + + + + + + + A + | 14 | Hyperplasia | 3 | 1 3.0| |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + | 15 | Hematopoietic Cell Proliferation | 2 2 2 3 4 2 3 2 3 2 2 2 4 3 2 | 15 2.5| Pigmentation | 2 1 1 1 1 1 1 1 1 1 | 10 1.1| |__________________________________________________________________________|____________| Thymus | + + + A + + + + + + + + A A + | 12 | Atrophy, Focal | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + | 15 | Dermis, Fibrosis, Focal | 3 | 1 3.0| Dermis, Subcutaneous Tissue, | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 12 NTP Experiment-Test: 96003-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01 Route: GAVAGE Time: 09:19:14 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 1| 2| 1| 2| 1| 2| 2| 2| 2| 2| 1| 1| | | DAY ON TEST | 4| 7| 7| 9| 7| 4| 7| 0| 7| 7| 7| 7| 3| 9| 6| | | | 6| 5| 5| 4| 5| 9| 5| 2| 5| 5| 5| 5| 4| 3| 4| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 1 MG/KG | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| INTEGUMENTARY SYSTEM - cont | | | Inflammation, Chronic Active, | | | Diffuse | 2 | 1 2.0| Epidermis, Hyperplasia, Focal | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + | 15 | Alveolus, Hyperplasia, Focal, | | | Histiocytic | 1 | 1 1.0| Arteriole, Necrosis, Focal | 3 | 1 3.0| Perivascular, Infiltration Cellular, | | | Lymphocyte | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + A | 14 | Inflammation, Chronic Active, Focal | 3 | 1 3.0| Necrosis, Focal | 3 | 1 3.0| Capsule, Inflammation, Acute, Focal | 1 | 1 1.0| Renal Tubule, Dilatation, Diffuse | 2 | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 13 NTP Experiment-Test: 96003-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01 Route: GAVAGE Time: 09:19:14 __________________________________________________________________________________________________________________________________ | 2| 1| 1| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| | | DAY ON TEST | 7| 3| 9| 7| 7| 7| 4| 7| 4| 9| 4| 7| 1| 7| 7| | | | 5| 6| 6| 5| 5| 5| 2| 5| 1| 3| 6| 5| 5| 5| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 2 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Intestine Large, Colon | + + A + + + + + + + + + A + + | 13 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + A + + + + + + + + + A + + | 13 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + A + + + + + + + + + A + + | 13 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + A A + + + + + + + + + A + + | 12 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + A A + + + + + + + + + A + + | 12 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + A A + + + + + + + + + A + + | 12 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + | 15 | Hematopoietic Cell Proliferation | 1 | 1 1.0| Necrosis, Focal | 2 3 | 2 2.5| Hepatocyte, Necrosis, Focal | 1 1 1 1 1 | 5 1.0| Hepatocyte, Vacuolization | | | Cytoplasmic, Focal | 1 1 2 1 | 4 1.3| |__________________________________________________________________________|____________| Stomach, Forestomach | + + A + + + + + + + + + A + + | 13 | |__________________________________________________________________________|____________| Stomach, Glandular | + + A + + + + + + + + + A + + | 13 | |__________________________________________________________________________|____________| Tooth | + + + + + + + | 7 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Heart | + | 1 | Atrium, Thrombosis, Focal | 4 | 1 4.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + A A + + + + + + + + + + + + | 13 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 14 NTP Experiment-Test: 96003-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01 Route: GAVAGE Time: 09:19:14 __________________________________________________________________________________________________________________________________ | 2| 1| 1| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| | | DAY ON TEST | 7| 3| 9| 7| 7| 7| 4| 7| 4| 9| 4| 7| 1| 7| 7| | | | 5| 6| 6| 5| 5| 5| 2| 5| 1| 3| 6| 5| 5| 5| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 2 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | Atrophy | 2 1 1 | 3 1.3| Subcapsular, Hyperplasia, Focal | 1 1 1 1 1 1 1 1 1 | 9 1.0| Zona Reticularis, Vacuolization | | | Cytoplasmic, Diffuse | 3 3 3 2 2 3 3 3 2 2 | 10 2.6| Zona Reticularis, Vacuolization | | | Cytoplasmic, Focal | 2 1 | 2 1.5| |__________________________________________________________________________|____________| Adrenal Medulla | + A A + + + + + + + + + M + + | 12 | |__________________________________________________________________________|____________| Pituitary Gland | + I + + + + + + M + + + + + + | 13 | |__________________________________________________________________________|____________| Thyroid Gland | + A + + + + + + + + + + + + + | 14 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + M + + | 14 | Degeneration | 2 | 1 2.0| Periovarian Tissue, Inflammation, | | | Chronic Active, Focal | 4 | 1 4.0| |__________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + A + + | 14 | Hydrometra | 3 3 | 2 3.0| Endometrium, Hyperplasia, Cystic | 2 2 2 1 | 4 1.8| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + M + + + + + | 14 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + + + + + M + + + + + | 14 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 15 NTP Experiment-Test: 96003-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01 Route: GAVAGE Time: 09:19:14 __________________________________________________________________________________________________________________________________ | 2| 1| 1| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| | | DAY ON TEST | 7| 3| 9| 7| 7| 7| 4| 7| 4| 9| 4| 7| 1| 7| 7| | | | 5| 6| 6| 5| 5| 5| 2| 5| 1| 3| 6| 5| 5| 5| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 2 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + | 15 | Hematopoietic Cell Proliferation | 3 3 2 2 2 2 2 3 2 2 3 1 1 | 13 2.2| Pigmentation | 1 1 1 1 1 1 1 1 1 2 1 1 1 1 | 14 1.1| Lymphoid Follicle, Depletion Cellular| 2 | 1 2.0| |__________________________________________________________________________|____________| Thymus | + + + + + + + + M + + + M + + | 13 | Atrophy, Diffuse | 4 4 | 2 4.0| Atrophy, Focal | 2 2 2 | 3 2.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + | 15 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + | 15 | Alveolus, Hemorrhage, Focal | 1 | 1 1.0| _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + | 15 | Papilla, Inflammation, Acute, Focal | 2 | 1 2.0| Renal Tubule, Dilatation, Focal | 1 1 | 2 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 16 NTP Experiment-Test: 96003-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01 Route: GAVAGE Time: 09:19:14 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 0| 2| | | DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 1| 7| 0| 8| 7| 7| 8| 7| | | | 5| 5| 5| 5| 5| 5| 5| 6| 5| 0| 8| 5| 5| 6| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 4 MG/KG | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + A + + A + + + + | 13 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + A + + A + + + + | 13 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + A + + A + + + + | 13 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + A + + A + + + + | 13 | Serosa, Inflammation, Acute, Focal | 2 | 1 2.0| |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + A + + A + + + + | 13 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + A + + A + + + + | 13 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + A + | 14 | Infiltration Cellular, Diffuse, | | | Polymorphonuclear | 3 | 1 3.0| Inflammation, Acute, Focal | 3 | 1 3.0| Necrosis, Chronic Active, Focal | 3 | 1 3.0| Necrosis, Focal | 2 | 1 2.0| Hepatocyte, Necrosis, Focal | 1 1 1 | 3 1.0| Hepatocyte, Vacuolization | | | Cytoplasmic, Diffuse | 2 2 2 4 | 4 2.5| Hepatocyte, Vacuolization | | | Cytoplasmic, Focal | 2 1 | 2 1.5| Serosa, Inflammation, Acute, Focal | 3 | 1 3.0| |__________________________________________________________________________|____________| Pancreas | + + + | 3 | Inflammation, Acute, Diffuse | 2 | 1 2.0| |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + A + | 14 | Muscularis, Serosa, Inflammation, | | | Acute, Focal | 4 | 1 4.0| |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 17 NTP Experiment-Test: 96003-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01 Route: GAVAGE Time: 09:19:14 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 0| 2| | | DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 1| 7| 0| 8| 7| 7| 8| 7| | | | 5| 5| 5| 5| 5| 5| 5| 6| 5| 0| 8| 5| 5| 6| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 4 MG/KG | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | Stomach, Glandular | + + + + + + + A + + + + + A + | 13 | Serosa, Inflammation, Acute, Focal | 2 | 1 2.0| |__________________________________________________________________________|____________| Tooth | + + + | 3 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + A + A + + + A + | 12 | Atrophy | 1 1 1 1 2 2 2 2 1 2 2 | 11 1.5| Subcapsular, Hyperplasia, Focal | 1 1 2 1 1 | 5 1.2| Zona Reticularis, Hyperplasia, | | | Diffuse | 4 | 1 4.0| Zona Reticularis, Infiltration | | | Cellular, Focal, Lymphocyte | 1 | 1 1.0| Zona Reticularis, Vacuolization | | | Cytoplasmic, Diffuse | 2 2 3 2 4 4 2 4 2 | 9 2.8| Zona Reticularis, Vacuolization | | | Cytoplasmic, Focal | 1 | 1 1.0| |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + A + A + + + A + | 12 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + M + | 14 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + A + + A + + A + | 12 | Ectopic Thymus | 1 | 1 1.0| Follicle, Cyst, Focal | 1 | 1 1.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 18 NTP Experiment-Test: 96003-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01 Route: GAVAGE Time: 09:19:14 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 0| 2| | | DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 1| 7| 0| 8| 7| 7| 8| 7| | | | 5| 5| 5| 5| 5| 5| 5| 6| 5| 0| 8| 5| 5| 6| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 4 MG/KG | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| GENITAL SYSTEM - cont | | | |__________________________________________________________________________|____________| Ovary | + + + + + + + + + M + + + A + | 13 | Atrophy | 2 | 1 2.0| Cyst | 2 | 1 2.0| Degeneration | 2 | 1 2.0| Inflammation, Acute, Diffuse | 4 | 1 4.0| Inflammation, Chronic Active, Diffuse| 4 | 1 4.0| Bilateral, Periovarian Tissue, Cyst | 2 | 1 2.0| Periovarian Tissue, Rete Ovarii, | | | Inflammation, Acute, Focal | 4 | 1 4.0| |__________________________________________________________________________|____________| Oviduct | A | | |__________________________________________________________________________|____________| Uterus | + + + + + + + A + + A + + A + | 12 | Atrophy | 3 | 1 3.0| Endometrium, Hyperplasia, Cystic | 1 4 3 2 2 3 2 2 1 2 | 10 2.2| Serosa, Inflammation, Acute, Focal | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Lymph Node | + | 1 | Iliac, Hyperplasia | 3 | 1 3.0| Renal, Hyperplasia | 4 | 1 4.0| |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + A + + A + + A + | 12 | Hyperplasia | 3 2 | 2 2.5| |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + A + + A + + A + | 12 | |__________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + + + A + + A + + A + | 12 | Hyperplasia | 3 | 1 3.0| |__________________________________________________________________________|____________| Spleen | + + + + + + + A + + + + + A + | 13 | Hematopoietic Cell Proliferation | 4 2 3 2 3 2 3 2 2 2 1 2 | 12 2.3| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 19 NTP Experiment-Test: 96003-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01 Route: GAVAGE Time: 09:19:14 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 0| 2| | | DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 1| 7| 0| 8| 7| 7| 8| 7| | | | 5| 5| 5| 5| 5| 5| 5| 6| 5| 0| 8| 5| 5| 6| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 4 MG/KG | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 | 11 1.0| Capsule, Inflammation, Acute, Focal | 4 4 | 2 4.0| |__________________________________________________________________________|____________| Thymus | + + + + + + + A + A A + + A + | 11 | Atrophy, Focal | 1 1 | 2 1.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + A + | 14 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + A + | 14 | Alveolus, Inflammation, Chronic, | | | Focal | 1 | 1 1.0| Mediastinum, Inflammation, Acute, | | | Focal | 3 | 1 3.0| Perivascular, Infiltration Cellular, | | | Lymphocyte | 1 | 1 1.0| _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + A + + + + + A + | 13 | Inflammation, Chronic Active, Focal | 4 | 1 4.0| Renal Tubule, Dilatation, Focal | 1 | 1 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 20 NTP Experiment-Test: 96003-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01 Route: GAVAGE Time: 09:19:14 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | | DAY ON TEST | 1| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| | | | 3| 5| 5| 5| 1| 5| 5| 5| 5| 5| 5| 6| 5| 5| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 8 MG/KG | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + | 15 | Infiltration Cellular, Diffuse, | | | Polymorphonuclear | 4 | 1 4.0| Necrosis, Focal | 1 1 | 2 1.0| Centrilobular, Vacuolization | | | Cytoplasmic | 1 | 1 1.0| Hepatocyte, Necrosis, Focal | 1 1 1 1 | 4 1.0| Hepatocyte, Vacuolization | | | Cytoplasmic, Diffuse | 2 2 2 | 3 2.0| Hepatocyte, Vacuolization | | | Cytoplasmic, Focal | 1 1 1 | 3 1.0| Hepatocyte, Periportal, | | | Vacuolization Cytoplasmic | 1 1 | 2 1.0| Hepatocyte, Centrilobular, | | | Vacuolization Cytoplasmic | 1 | 1 1.0| |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Tooth | + + + | 3 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | None | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 21 NTP Experiment-Test: 96003-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01 Route: GAVAGE Time: 09:19:14 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | | DAY ON TEST | 1| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| | | | 3| 5| 5| 5| 1| 5| 5| 5| 5| 5| 5| 6| 5| 5| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 8 MG/KG | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + | 15 | Atrophy | 2 1 1 1 | 4 1.3| Mineralization, Focal | 1 | 1 1.0| Subcapsular, Hyperplasia, Focal | 1 1 1 1 1 1 | 6 1.0| Zona Reticularis, Vacuolization | | | Cytoplasmic, Diffuse | 3 3 2 3 3 2 2 3 2 3 2 3 | 12 2.6| Zona Reticularis, Vacuolization | | | Cytoplasmic, Focal | 1 1 2 | 3 1.3| |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + M + + + + + + + + + + | 14 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + M + + + + + + + + + | 14 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + | 15 | Cyst, Focal | 3 | 1 3.0| Degeneration | 1 | 1 1.0| Inflammation, Diffuse | 4 | 1 4.0| Periovarian Tissue, Inflammation, | | | Acute, Focal | 2 | 1 2.0| |__________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + | 15 | Endometrium, Hyperplasia, Cystic | 2 4 3 2 1 2 1 2 2 2 2 2 3 | 13 2.2| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + | 15 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 22 NTP Experiment-Test: 96003-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01 Route: GAVAGE Time: 09:19:14 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | | DAY ON TEST | 1| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| | | | 3| 5| 5| 5| 1| 5| 5| 5| 5| 5| 5| 6| 5| 5| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 8 MG/KG | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | Hyperplasia | 2 3 | 2 2.5| Necrosis, Focal | 2 | 1 2.0| |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + + + + + + + + + + I | 14 | Inflammation, Diffuse | 3 | 1 3.0| |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + | 15 | Hematopoietic Cell Proliferation | 4 2 2 1 1 2 2 1 2 2 2 2 2 2 | 14 1.9| Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 14 1.0| |__________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + + + | 15 | Atrophy, Diffuse | 4 | 1 4.0| Atrophy, Focal | 1 1 1 2 3 2 | 6 1.7| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + | 15 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + | 2 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + | 15 | Alveolus, Hemorrhage, Focal | 1 | 1 1.0| Perivascular, Infiltration Cellular, | | | Lymphocyte | 1 | 1 1.0| _____________________________________________________________________________________________________________________| | * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 23 NTP Experiment-Test: 96003-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01 Route: GAVAGE Time: 09:19:14 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | | DAY ON TEST | 1| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| | | | 3| 5| 5| 5| 1| 5| 5| 5| 5| 5| 5| 6| 5| 5| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 8 MG/KG | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | | _____________________________________________________________________________________________________________________|____________| SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Harderian Gland | + | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + | 15 | Infiltration Cellular, Focal, | | | Lymphocyte | 1 | 1 1.0| Bilateral, Inflammation, Acute, Focal| 4 | 1 4.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 24 NTP Experiment-Test: 96003-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01 Route: GAVAGE Time: 09:19:14 __________________________________________________________________________________________________________________________________ | 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | | DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 4| 7| 7| 7| 7| | | | 5| 3| 5| 5| 5| 5| 5| 5| 5| 5| 1| 5| 5| 5| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | MICE:TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | VEHICLE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| | L | CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Liver | + + + + + + + A + + + + + + + | 14 | Hepatocyte, Necrosis, Focal | 1 1 | 2 1.0| Hepatocyte, Centrilobular, | | | Hypertrophy | 1 | 1 1.0| Hepatocyte, Centrilobular, | | | Vacuolization Cytoplasmic | 1 1 | 2 1.0| |__________________________________________________________________________|____________| Mesentery | + | 1 | Fat, Necrosis, Focal | 4 | 1 4.0| |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Tooth | + + + + + | 5 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 25 NTP Experiment-Test: 96003-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01 Route: GAVAGE Time: 09:19:14 __________________________________________________________________________________________________________________________________ | 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | | DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 4| 7| 7| 7| 7| | | | 5| 3| 5| 5| 5| 5| 5| 5| 5| 5| 1| 5| 5| 5| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | MICE:TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | VEHICLE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| | L | CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | Adrenal Cortex | + + + + + + + + + + + + + + + | 15 | Atrophy | 3 2 3 3 3 3 3 2 4 3 3 3 3 3 3 | 15 2.9| Hypertrophy, Focal | 1 1 1 1 1 1 1 1 1 1 1 2 2 | 13 1.2| Zona Reticularis, Vacuolization | | | Cytoplasmic, Focal | 1 | 1 1.0| |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + I + + + + | 14 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + | 15 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Penis | + + + | 3 | |__________________________________________________________________________|____________| Preputial Gland | + | 1 | Ectasia | 3 | 1 3.0| |__________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + | 15 | Germinal Epithelium, Degeneration, | | | Focal | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + | 15 | Hyperplasia | 2 | 1 2.0| |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + A + + + + + + + | 14 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 26 NTP Experiment-Test: 96003-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01 Route: GAVAGE Time: 09:19:14 __________________________________________________________________________________________________________________________________ | 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | | DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 4| 7| 7| 7| 7| | | | 5| 3| 5| 5| 5| 5| 5| 5| 5| 5| 1| 5| 5| 5| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | MICE:TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | VEHICLE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| | L | CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | |__________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + + + + M + + + + + + | 14 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + | 15 | Hematopoietic Cell Proliferation | 1 1 1 2 1 1 1 1 1 1 1 1 1 1 | 14 1.1| Pigmentation | 1 1 1 1 1 1 1 1 | 8 1.0| Lymphoid Follicle, Depletion Cellular| 3 | 1 3.0| |__________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + + + | 15 | Atrophy, Diffuse | 3 2 3 | 3 2.7| Atrophy, Focal | 1 | 1 1.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + | 15 | Epidermis, Hyperplasia, Focal | 1 | 1 1.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + | 15 | Perivascular, Infiltration Cellular, | | | Lymphocyte | 1 | 1 1.0| _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | + | 1 | Retina, Atrophy | 3 | 1 3.0| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 27 NTP Experiment-Test: 96003-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01 Route: GAVAGE Time: 09:19:14 __________________________________________________________________________________________________________________________________ | 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | | DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 4| 7| 7| 7| 7| | | | 5| 3| 5| 5| 5| 5| 5| 5| 5| 5| 1| 5| 5| 5| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | MICE:TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | VEHICLE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| | L | CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | | _____________________________________________________________________________________________________________________|____________| URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + | 15 | Renal Tubule, Dilatation, Focal | 1 | 1 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 28 NTP Experiment-Test: 96003-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01 Route: GAVAGE Time: 09:19:14 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 1| 1| 2| 2| 2| 1| 2| 0| 2| | | DAY ON TEST | 7| 7| 0| 7| 7| 7| 6| 8| 1| 7| 7| 6| 7| 0| 7| | | | 5| 5| 6| 5| 5| 5| 3| 6| 9| 5| 5| 9| 5| 8| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | MICE:TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 0.5 | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | L | MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + | 1 | Periesophageal Tissue, Inflammation, | | | Chronic Active, Focal | 2 | 1 2.0| |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + A + + + + A + + + | 13 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + A + + + + A + + + | 13 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + A + + + + A + + + | 13 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + A + + + + A + + + | 13 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + A + + + + A + + + | 13 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + A + + + + A + + + | 13 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + | 15 | Necrosis, Focal | 1 | 1 1.0| Hepatocyte, Necrosis, Focal | 1 1 1 | 3 1.0| Hepatocyte, Vacuolization | | | Cytoplasmic, Diffuse | 4 | 1 4.0| Serosa, Inflammation, Chronic Active,| | | Focal | 4 | 1 4.0| |__________________________________________________________________________|____________| Mesentery | + | 1 | Fat, Necrosis, Focal | 1 | 1 1.0| |__________________________________________________________________________|____________| Salivary Glands | + | 1 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + A + + + | 14 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + A + + + | 14 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 29 NTP Experiment-Test: 96003-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01 Route: GAVAGE Time: 09:19:14 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 1| 1| 2| 2| 2| 1| 2| 0| 2| | | DAY ON TEST | 7| 7| 0| 7| 7| 7| 6| 8| 1| 7| 7| 6| 7| 0| 7| | | | 5| 5| 6| 5| 5| 5| 3| 6| 9| 5| 5| 9| 5| 8| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | MICE:TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 0.5 | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | L | MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | Tooth | + + + + + | 5 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + A + + + | 14 | Atrophy | 3 3 3 3 3 3 1 3 3 3 3 3 3 | 13 2.8| Hypertrophy, Focal | 1 1 1 1 1 1 1 1 1 1 | 10 1.0| |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + A + + + | 14 | |__________________________________________________________________________|____________| Islets, Pancreatic | + | 1 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + M + | 14 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + A + + + + A + + + | 13 | Inflammation, Chronic Active, Focal | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Preputial Gland | + + | 2 | Ectasia | 3 | 1 3.0| Inflammation, Chronic Active, Focal | 2 | 1 2.0| |__________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + | 15 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 30 NTP Experiment-Test: 96003-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01 Route: GAVAGE Time: 09:19:14 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 1| 1| 2| 2| 2| 1| 2| 0| 2| | | DAY ON TEST | 7| 7| 0| 7| 7| 7| 6| 8| 1| 7| 7| 6| 7| 0| 7| | | | 5| 5| 6| 5| 5| 5| 3| 6| 9| 5| 5| 9| 5| 8| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | MICE:TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 0.5 | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | L | MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + A + + + + A + + + | 13 | Hyperplasia, Histiocytic | 2 | 1 2.0| Hyperplasia | 3 | 1 3.0| |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + A + + + | 14 | Hyperplasia | 2 | 1 2.0| |__________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + + A + + + + A + + + | 13 | Hyperplasia | 2 | 1 2.0| |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + A + + + | 14 | Congestion | 2 | 1 2.0| Hematopoietic Cell Proliferation | 1 1 2 1 2 1 1 2 1 1 1 2 1 1 | 14 1.3| Pigmentation | 1 1 1 1 1 1 1 1 1 1 | 10 1.0| Lymphoid Follicle, Depletion Cellular| 2 | 1 2.0| |__________________________________________________________________________|____________| Thymus | + + + + + + + + I + + A + + + | 13 | Atrophy, Diffuse | 4 4 3 | 3 3.7| Atrophy, Focal | 2 2 | 2 2.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + | 15 | Subcutaneous Tissue, Inflammation, | | | Chronic Active, Focal | 4 | 1 4.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 31 NTP Experiment-Test: 96003-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01 Route: GAVAGE Time: 09:19:14 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 1| 1| 2| 2| 2| 1| 2| 0| 2| | | DAY ON TEST | 7| 7| 0| 7| 7| 7| 6| 8| 1| 7| 7| 6| 7| 0| 7| | | | 5| 5| 6| 5| 5| 5| 3| 6| 9| 5| 5| 9| 5| 8| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | MICE:TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 0.5 | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | L | MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| RESPIRATORY SYSTEM - cont | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + | 15 | Alveolar Epithelium, Hyperplasia, | | | Focal | 2 | 1 2.0| Arteriole, Capillary, Perivascular, | | | Inflammation, Acute | 3 | 1 3.0| Perivascular, Infiltration Cellular, | | | Focal, Lymphocyte | 1 | 1 1.0| |__________________________________________________________________________|____________| Trachea | + | 1 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Lacrimal Gland | + | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + A + + + | 14 | Inflammation, Acute, Focal | 3 | 1 3.0| Capsule, Cortex, Inflammation, | | | Chronic Active, Focal | 4 | 1 4.0| Renal Tubule, Dilatation, Focal | 1 | 1 1.0| |__________________________________________________________________________|____________| Urinary Bladder | + | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 32 NTP Experiment-Test: 96003-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01 Route: GAVAGE Time: 09:19:14 __________________________________________________________________________________________________________________________________ | 2| 2| 1| 2| 1| 2| 2| 2| 2| 2| 2| 0| 2| 2| 1| | | DAY ON TEST | 0| 7| 6| 7| 5| 7| 7| 7| 2| 7| 7| 6| 7| 7| 1| | | | 6| 5| 5| 5| 0| 5| 5| 5| 6| 5| 5| 9| 5| 5| 7| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | MICE:TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 1 MG/KG | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + A + + A | 13 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + A + + A | 13 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + A + + A | 13 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + A + + A + + A | 12 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + A + + A + + A | 12 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + A + + A + + A | 12 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + A + + + | 14 | Hepatocyte, Necrosis, Focal | 1 1 1 1 1 | 5 1.0| Hepatocyte, Centrilobular, | | | Vacuolization Cytoplasmic | 1 2 | 2 1.5| Sinusoid, Inflammation, Focal | 2 | 1 2.0| |__________________________________________________________________________|____________| Salivary Glands | + | 1 | Necrosis, Focal | 3 | 1 3.0| |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + A + + + | 14 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + A + + + | 14 | |__________________________________________________________________________|____________| Tooth | + + + + | 4 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + A | 14 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 33 NTP Experiment-Test: 96003-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01 Route: GAVAGE Time: 09:19:14 __________________________________________________________________________________________________________________________________ | 2| 2| 1| 2| 1| 2| 2| 2| 2| 2| 2| 0| 2| 2| 1| | | DAY ON TEST | 0| 7| 6| 7| 5| 7| 7| 7| 2| 7| 7| 6| 7| 7| 1| | | | 6| 5| 5| 5| 0| 5| 5| 5| 6| 5| 5| 9| 5| 5| 7| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | MICE:TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 1 MG/KG | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | Atrophy | 3 3 3 3 1 2 3 2 3 3 3 2 3 3 | 14 2.6| Degeneration, Focal | 1 | 1 1.0| Hypertrophy, Focal | 1 1 1 1 1 1 1 1 1 | 9 1.0| |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + A | 14 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + I + + + A + + A | 12 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + A + + + | 14 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | |__________________________________________________________________________|____________| Tissue NOS | + | 1 | Mediastinum, Inflammation, Chronic | | | Active, Focal | 4 | 1 4.0| _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Preputial Gland | + + | 2 | Ectasia | 3 3 | 2 3.0| |__________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + | 15 | Germinal Epithelium, Degeneration, | | | Focal | 3 1 1 1 3 | 5 1.8| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + M + + + + + + + + + + + + | 14 | Hyperplasia | 3 3 | 2 3.0| |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + A + + + | 14 | Inflammation, Chronic Active, Focal | 3 | 1 3.0| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 34 NTP Experiment-Test: 96003-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01 Route: GAVAGE Time: 09:19:14 __________________________________________________________________________________________________________________________________ | 2| 2| 1| 2| 1| 2| 2| 2| 2| 2| 2| 0| 2| 2| 1| | | DAY ON TEST | 0| 7| 6| 7| 5| 7| 7| 7| 2| 7| 7| 6| 7| 7| 1| | | | 6| 5| 5| 5| 0| 5| 5| 5| 6| 5| 5| 9| 5| 5| 7| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | MICE:TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 1 MG/KG | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | |__________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + + + + + + + M + + + | 14 | Hyperplasia | 2 | 1 2.0| |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + A + + + | 14 | Hematopoietic Cell Proliferation | 2 2 1 1 1 2 1 1 1 2 2 2 1 | 13 1.5| Inflammation, Chronic Active, Focal | 1 | 1 1.0| Pigmentation | 1 1 1 1 1 1 1 1 1 | 9 1.0| |__________________________________________________________________________|____________| Thymus | + + + + M + + + + + + M + + A | 12 | Atrophy, Diffuse | 3 3 | 2 3.0| Atrophy, Focal | 1 | 1 1.0| Hyperplasia | 2 2 | 2 2.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + | 15 | Subcutaneous Tissue, Necrosis, Focal | 4 | 1 4.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + A + + + | 14 | Inflammation, Chronic Active, Focal | 2 | 1 2.0| Alveolus, Hemorrhage, Focal | 1 | 1 1.0| Perivascular, Infiltration Cellular, | | | Focal, Lymphocyte | 1 | 1 1.0| Serosa, Mediastinum, Inflammation, | | | Chronic Active, Diffuse | 4 | 1 4.0| _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | None | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 35 NTP Experiment-Test: 96003-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01 Route: GAVAGE Time: 09:19:14 __________________________________________________________________________________________________________________________________ | 2| 2| 1| 2| 1| 2| 2| 2| 2| 2| 2| 0| 2| 2| 1| | | DAY ON TEST | 0| 7| 6| 7| 5| 7| 7| 7| 2| 7| 7| 6| 7| 7| 1| | | | 6| 5| 5| 5| 0| 5| 5| 5| 6| 5| 5| 9| 5| 5| 7| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | MICE:TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 1 MG/KG | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | | _____________________________________________________________________________________________________________________|____________| URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + A + + + | 14 | Inflammation, Chronic Active, Focal | 4 | 1 4.0| Renal Tubule, Dilatation, Diffuse | 1 | 1 1.0| Renal Tubule, Dilatation, Focal | 1 | 1 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 36 NTP Experiment-Test: 96003-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01 Route: GAVAGE Time: 09:19:14 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 0| 1| 2| | | DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 1| 4| 7| | | | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 2| 2| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | MICE:TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 2 MG/KG | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + | 1 | Muscularis, Periesophageal Tissue, | | | Inflammation, Chronic Active, | | | Diffuse | 4 | 1 4.0| |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + A + + + + + + + | 14 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + A + + + + + + + | 14 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + A + + + + + + + | 14 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + | 15 | Hepatocyte, Vacuolization | | | Cytoplasmic, Focal | 1 | 1 1.0| |__________________________________________________________________________|____________| Mesentery | + + | 2 | Fat, Necrosis, Focal | 4 4 | 2 4.0| |__________________________________________________________________________|____________| Salivary Glands | + | 1 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Tooth | + + + | 3 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 37 NTP Experiment-Test: 96003-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01 Route: GAVAGE Time: 09:19:14 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 0| 1| 2| | | DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 1| 4| 7| | | | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 2| 2| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | MICE:TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 2 MG/KG | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| CARDIOVASCULAR SYSTEM - cont | | | |__________________________________________________________________________|____________| Blood Vessel | + | 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + A + + | 14 | Atrophy | 3 3 4 3 2 3 4 3 4 4 4 3 3 3 | 14 3.3| Hypertrophy, Focal | 1 1 1 1 1 1 1 1 1 1 1 | 11 1.0| Subcapsular, Hyperplasia, Focal | 2 | 1 2.0| Zona Reticularis, Vacuolization | | | Cytoplasmic, Focal | 1 | 1 1.0| |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + A + + | 14 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + I + + + + + A + + | 13 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + | 15 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Preputial Gland | + | 1 | Ectasia | 3 | 1 3.0| |__________________________________________________________________________|____________| Seminal Vesicle | + | 1 | Dilatation | 2 | 1 2.0| |__________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + | 15 | Germinal Epithelium, Degeneration, | | | Diffuse | 3 | 1 3.0| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 38 NTP Experiment-Test: 96003-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01 Route: GAVAGE Time: 09:19:14 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 0| 1| 2| | | DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 1| 4| 7| | | | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 2| 2| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | MICE:TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 2 MG/KG | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| GENITAL SYSTEM - cont | | | Germinal Epithelium, Degeneration, | | | Focal | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + + + + + + + + + + + | 15 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + | 15 | Hematopoietic Cell Proliferation | 1 1 2 2 2 2 1 2 1 2 1 2 1 1 1 | 15 1.5| Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 | 12 1.0| Lymphoid Follicle, Depletion Cellular| 2 | 1 2.0| |__________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + + + | 15 | Atrophy, Diffuse | 3 2 | 2 2.5| Atrophy, Focal | 2 1 2 1 | 4 1.5| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + | 15 | Subcutaneous Tissue, Inflammation, | | | Chronic Active, Focal | 4 | 1 4.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 39 NTP Experiment-Test: 96003-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01 Route: GAVAGE Time: 09:19:14 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 0| 1| 2| | | DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 1| 4| 7| | | | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 2| 2| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | MICE:TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 2 MG/KG | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| RESPIRATORY SYSTEM - cont | | | Lung | + + + + + + + + + + + + + + + | 15 | Alveolus, Hemorrhage, Focal | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + | 15 | Renal Tubule, Dilatation, Focal | 1 | 1 1.0| |__________________________________________________________________________|____________| Urinary Bladder | + | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 40 NTP Experiment-Test: 96003-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01 Route: GAVAGE Time: 09:19:14 __________________________________________________________________________________________________________________________________ | 2| 2| 0| 2| 2| 1| 1| 2| 2| 1| 2| 2| 2| 2| 2| | | DAY ON TEST | 7| 4| 0| 7| 7| 2| 2| 7| 7| 6| 3| 2| 0| 7| 1| | | | 5| 1| 4| 5| 5| 9| 7| 5| 5| 7| 8| 2| 1| 5| 8| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | MICE:TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 4 MG/KG | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + | 1 | Periesophageal Tissue, Inflammation, | | | Chronic Active, Diffuse | 4 | 1 4.0| |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + A + + A A + + + + | 12 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + A + + A A + + + + | 12 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + A + + A A A + + + | 11 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + A + + A A A + + + | 11 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + A + + A A A + + + | 11 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + A + + A A + + + + | 12 | |__________________________________________________________________________|____________| Liver | + + + + + + A + + + + + + + + | 14 | Hepatocyte, Necrosis, Focal | 1 1 | 2 1.0| Hepatocyte, Vacuolization | | | Cytoplasmic, Focal | 2 | 1 2.0| |__________________________________________________________________________|____________| Salivary Glands | A | | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + A + + + + A + + + | 13 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + A + + A A A + + + | 11 | |__________________________________________________________________________|____________| Tooth | + + + + + + | 6 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 41 NTP Experiment-Test: 96003-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01 Route: GAVAGE Time: 09:19:14 __________________________________________________________________________________________________________________________________ | 2| 2| 0| 2| 2| 1| 1| 2| 2| 1| 2| 2| 2| 2| 2| | | DAY ON TEST | 7| 4| 0| 7| 7| 2| 2| 7| 7| 6| 3| 2| 0| 7| 1| | | | 5| 1| 4| 5| 5| 9| 7| 5| 5| 7| 8| 2| 1| 5| 8| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | MICE:TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 4 MG/KG | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + A + + A A + + + + | 12 | Atrophy | 3 3 4 2 2 3 3 2 3 3 | 10 2.8| Hypertrophy, Focal | 1 1 1 1 2 1 1 1 1 1 | 10 1.1| Zona Reticularis, Vacuolization | | | Cytoplasmic, Focal | 1 | 1 1.0| |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + A + + A A + + + + | 12 | |__________________________________________________________________________|____________| Pituitary Gland | + I + + + + A + + A M I I + + | 9 | |__________________________________________________________________________|____________| Thyroid Gland | + + M + + + A + + A A A A + + | 9 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Epididymis | + + + + + + A + + + + + + + + | 14 | |__________________________________________________________________________|____________| Penis | + | 1 | |__________________________________________________________________________|____________| Preputial Gland | + + + + | 4 | Ectasia | 3 3 3 3 | 4 3.0| |__________________________________________________________________________|____________| Testes | + + + + + + A + + + + + + + + | 14 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + M + + + A + + + + | 13 | Hyperplasia | 2 2 3 | 3 2.3| |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + A + + A A + + + + | 12 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 42 NTP Experiment-Test: 96003-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01 Route: GAVAGE Time: 09:19:14 __________________________________________________________________________________________________________________________________ | 2| 2| 0| 2| 2| 1| 1| 2| 2| 1| 2| 2| 2| 2| 2| | | DAY ON TEST | 7| 4| 0| 7| 7| 2| 2| 7| 7| 6| 3| 2| 0| 7| 1| | | | 5| 1| 4| 5| 5| 9| 7| 5| 5| 7| 8| 2| 1| 5| 8| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | MICE:TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 4 MG/KG | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | Lymph Node, Mediastinal | + + + + + + M + + A A A M + + | 10 | |__________________________________________________________________________|____________| Spleen | + + + + + + A + + + + + + + + | 14 | Congestion | 2 | 1 2.0| Hematopoietic Cell Proliferation | 1 1 2 2 2 2 2 3 2 2 2 2 | 12 1.9| Pigmentation | 1 1 1 1 1 1 | 6 1.0| Lymphoid Follicle, Depletion Cellular| 2 | 1 2.0| |__________________________________________________________________________|____________| Thymus | M + + + + M A + + A A + + + + | 10 | Atrophy, Diffuse | 3 3 4 | 3 3.3| Atrophy, Focal | 2 | 1 2.0| Hyperplasia, Focal | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Skin | + + + + + + A + + + + + + + + | 14 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + A + + + + + + + + | 14 | Arteriole, Artery, Inflammation, | | | Chronic Active, Focal | 3 3 | 2 3.0| Perivascular, Infiltration Cellular, | | | Lymphocyte | 1 | 1 1.0| _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | + | 1 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 43 NTP Experiment-Test: 96003-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01 Route: GAVAGE Time: 09:19:14 __________________________________________________________________________________________________________________________________ | 2| 2| 0| 2| 2| 1| 1| 2| 2| 1| 2| 2| 2| 2| 2| | | DAY ON TEST | 7| 4| 0| 7| 7| 2| 2| 7| 7| 6| 3| 2| 0| 7| 1| | | | 5| 1| 4| 5| 5| 9| 7| 5| 5| 7| 8| 2| 1| 5| 8| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | MICE:TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 4 MG/KG | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | | _____________________________________________________________________________________________________________________|____________| SPECIAL SENSES SYSTEM - cont | | | Retina, Atrophy | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + A + + + + + + + + | 14 | Bilateral, Cortex, Inflammation, | | | Acute, Focal | 3 | 1 3.0| Cortex, Inflammation, Acute, Focal | 2 3 | 2 2.5| Renal Tubule, Degeneration, Focal | 1 2 | 2 1.5| Renal Tubule, Dilatation, Diffuse | 2 | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 44 NTP Experiment-Test: 96003-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01 Route: GAVAGE Time: 09:19:14 __________________________________________________________________________________________________________________________________ | 2| 2| 0| 2| 2| 2| 1| 2| 2| 2| 2| 1| 2| 2| 2| | | DAY ON TEST | 7| 7| 0| 7| 7| 7| 0| 7| 4| 7| 7| 0| 7| 7| 7| | | | 5| 5| 5| 5| 5| 5| 8| 5| 3| 5| 5| 7| 5| 5| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | MICE:TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 8 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + | 1 | Periesophageal Tissue, Inflammation, | | | Chronic Active, Diffuse | 3 | 1 3.0| |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + A + + + + + + + + | 14 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + A + + + + + + + + | 14 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + A + + + + + + + + | 14 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + A + + + + + + + + | 14 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + A + + + + A + + + | 13 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + A + + + + + + + + | 14 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + | 15 | Necrosis, Focal | 1 | 1 1.0| Hepatocyte, Vacuolization | | | Cytoplasmic, Focal | 1 1 | 2 1.0| Hepatocyte, Centrilobular, | | | Vacuolization Cytoplasmic | 1 | 1 1.0| |__________________________________________________________________________|____________| Pancreas | + | 1 | Acinus, Atrophy, Diffuse | 4 | 1 4.0| |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + A + + + + + + + + | 14 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + A + + + + + + + + | 14 | |__________________________________________________________________________|____________| Tooth | + + + + | 4 | Peridontal Tissue, Inflammation, | | | Chronic Active, Focal | 4 | 1 4.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | None | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 45 NTP Experiment-Test: 96003-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01 Route: GAVAGE Time: 09:19:14 __________________________________________________________________________________________________________________________________ | 2| 2| 0| 2| 2| 2| 1| 2| 2| 2| 2| 1| 2| 2| 2| | | DAY ON TEST | 7| 7| 0| 7| 7| 7| 0| 7| 4| 7| 7| 0| 7| 7| 7| | | | 5| 5| 5| 5| 5| 5| 8| 5| 3| 5| 5| 7| 5| 5| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | MICE:TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 8 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + A + + + + + + + + | 14 | Atrophy | 3 3 2 3 3 3 2 3 3 3 3 2 | 12 2.8| Hypertrophy, Focal | 1 1 1 1 1 1 1 1 1 1 1 | 11 1.0| Zona Reticularis, Vacuolization | | | Cytoplasmic, Focal | 1 | 1 1.0| |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + A + + + + + + + + | 14 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + A + M + + + + + + | 13 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + A + + + + + + + + | 14 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | |__________________________________________________________________________|____________| Tissue NOS | + | 1 | Fat, Necrosis, Focal | 4 | 1 4.0| _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Epididymis | + + + + + + A + + + + + + + + | 14 | |__________________________________________________________________________|____________| Preputial Gland | + + | 2 | Ectasia | 3 3 | 2 3.0| |__________________________________________________________________________|____________| Seminal Vesicle | + | 1 | Bilateral, Dilatation | 2 | 1 2.0| |__________________________________________________________________________|____________| Testes | + + + + + + A + + + + + + + + | 14 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + | 15 | Hyperplasia | 2 | 1 2.0| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 46 NTP Experiment-Test: 96003-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01 Route: GAVAGE Time: 09:19:14 __________________________________________________________________________________________________________________________________ | 2| 2| 0| 2| 2| 2| 1| 2| 2| 2| 2| 1| 2| 2| 2| | | DAY ON TEST | 7| 7| 0| 7| 7| 7| 0| 7| 4| 7| 7| 0| 7| 7| 7| | | | 5| 5| 5| 5| 5| 5| 8| 5| 3| 5| 5| 7| 5| 5| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | MICE:TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 8 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + A + + + + + + + + | 14 | |__________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + M + + + + + + + + + | 14 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + | 15 | Hematopoietic Cell Proliferation | 1 1 1 1 1 2 3 2 2 1 2 1 2 | 13 1.5| Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 | 11 1.0| |__________________________________________________________________________|____________| Thymus | + + + + I + A + + + + + + + + | 13 | Atrophy, Diffuse | 3 | 1 3.0| Atrophy, Focal | 1 | 1 1.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + | 15 | Hyperkeratosis, Focal | 1 | 1 1.0| Dermis, Inflammation, Chronic Active,| | | Focal | 2 | 1 2.0| Epidermis, Hyperplasia, Focal | 2 1 | 2 1.5| Subcutaneous Tissue, Necrosis, Focal | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + | 15 | Alveolus, Hemorrhage, Focal | 2 | 1 2.0| Mediastinum, Inflammation, Chronic | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 47 NTP Experiment-Test: 96003-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/30/01 Route: GAVAGE Time: 09:19:14 __________________________________________________________________________________________________________________________________ | 2| 2| 0| 2| 2| 2| 1| 2| 2| 2| 2| 1| 2| 2| 2| | | DAY ON TEST | 7| 7| 0| 7| 7| 7| 0| 7| 4| 7| 7| 0| 7| 7| 7| | | | 5| 5| 5| 5| 5| 5| 8| 5| 3| 5| 5| 7| 5| 5| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | MICE:TGAC (FVB/N) HEMIZYGOUS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 8 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| RESPIRATORY SYSTEM - cont | | | Active, Diffuse | 4 | 1 4.0| Perivascular, Infiltration Cellular, | | | Lymphocyte | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + A + + + + + + + + | 14 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 48 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------