TDMS Study 96003-05 Pathology Tables
NTP Experiment-Test: 96003-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/26/01 Route: GAVAGE Time: 13:49:05 FINAL#1/MICE Facility: BIORELIANCE Chemical CAS #: 106-95-6 Lock Date: 10/18/00 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All a Number of animals examined microscopically at site and number of animals with lesion Page 1 NTP Experiment-Test: 96003-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/26/01 Route: GAVAGE Time: 13:49:05 ____________________________________________________________________________________________________________________________________ MICE:P53+/-(C57BL/6) FEMALE VEHICLE 0.5 1 MG/KG 2 MG/KG 4 MG/KG 8 MG/KG CONTROL MG/KG ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 15 15 15 15 15 15 Early Deaths Moribund Sacrifice 2 1 2 1 Natural Death 1 1 Survivors Terminal Sacrifice 13 14 13 14 15 13 Animals Examined Microscopically 15 15 15 15 15 15 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Intestine Small, Duodenum (15) (15) (15) (14) (15) (14) Polyp Inflammatory, Focal 1 (7%) Liver (15) (15) (15) (14) (15) (15) Infiltration Cellular, Focal, Lymphocyte 3 (20%) 2 (13%) 4 (27%) 6 (43%) 7 (47%) 2 (13%) Necrosis, Focal 1 (7%) Tension Lipidosis 1 (7%) Hepatocyte, Necrosis, Focal 1 (7%) 1 (7%) 1 (7%) Hepatocyte, Vacuolization Cytoplasmic, Focal 1 (7%) 2 (13%) Hepatocyte, Periportal, Vacuolization Cytoplasmic 8 (53%) 8 (53%) 8 (53%) 6 (43%) 3 (20%) 5 (33%) Salivary Glands (1) Infiltration Cellular, Focal, Lymphocyte 1 (100%) Stomach, Forestomach (15) (15) (15) (14) (15) (14) Hyperkeratosis, Focal 1 (7%) Epithelium, Hyperplasia, Focal 1 (7%) Muscularis, Inflammation, Acute, Focal 1 (7%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM None ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (15) (15) (15) (14) (15) (15) Subcapsular, Hyperplasia, Focal 13 (87%) 14 (93%) 15 (100%) 12 (86%) 12 (80%) 13 (87%) Parathyroid Gland (1) Cyst 1 (100%) Pituitary Gland (14) (14) (15) (13) (15) (13) a Number of animals examined microscopically at site and number of animals with lesion Page 2 NTP Experiment-Test: 96003-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/26/01 Route: GAVAGE Time: 13:49:05 ____________________________________________________________________________________________________________________________________ MICE:P53+/-(C57BL/6) FEMALE VEHICLE 0.5 1 MG/KG 2 MG/KG 4 MG/KG 8 MG/KG CONTROL MG/KG ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - CONT Cyst, Focal 1 (7%) Thyroid Gland (14) (15) (15) (14) (14) (15) Ectopic Thymus 1 (7%) 1 (7%) 1 (7%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Ovary (15) (15) (15) (14) (15) (14) Cyst 1 (7%) Degeneration 1 (7%) Uterus (15) (15) (15) (14) (15) (14) Inflammation, Acute 1 (7%) Thrombosis, Focal 1 (7%) Endometrium, Hyperplasia, Cystic 13 (87%) 13 (87%) 14 (93%) 13 (93%) 14 (93%) 14 (100%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Lymph Node (1) (1) Hyperplasia 1 (100%) Lymph Node, Mandibular (15) (14) (15) (14) (15) (13) Hyperplasia 1 (7%) 1 (7%) 1 (7%) Lymph Node, Mesenteric (15) (14) (15) (12) (15) (15) Hyperplasia 1 (7%) Lymph Node, Mediastinal (15) (14) (15) (14) (15) (14) Hyperplasia 1 (7%) Spleen (15) (15) (15) (14) (15) (15) Hematopoietic Cell Proliferation 8 (53%) 6 (40%) 7 (47%) 10 (71%) 9 (60%) 7 (47%) Hyperplasia, Lymphoid 1 (7%) 1 (7%) Pigmentation 4 (27%) 8 (53%) 4 (27%) 2 (14%) 2 (13%) 2 (13%) Lymphoid Follicle, Depletion Cellular, Diffuse 1 (7%) 1 (7%) Lymphoid Follicle, Hyperplasia 1 (7%) Thymus (14) (14) (14) (14) (15) (14) Atrophy, Diffuse 1 (7%) 2 (13%) 1 (7%) Atrophy, Focal 1 (7%) 2 (14%) Hyperplasia, Focal 1 (7%) ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion Page 3 NTP Experiment-Test: 96003-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/26/01 Route: GAVAGE Time: 13:49:05 ____________________________________________________________________________________________________________________________________ MICE:P53+/-(C57BL/6) FEMALE VEHICLE 0.5 1 MG/KG 2 MG/KG 4 MG/KG 8 MG/KG CONTROL MG/KG ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Skin (15) (15) (15) (14) (15) (15) Epidermis, Hyperplasia, Diffuse 1 (7%) Epidermis, Hyperplasia, Focal 2 (13%) 1 (7%) Subcutaneous Tissue, Edema, Diffuse 1 (7%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM Bone (2) (1) (1) Metatarsal, Fracture 1 (50%) ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM None ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (15) (15) (15) (15) (15) (15) Alveolar Epithelium, Hyperplasia, Focal 1 (7%) Alveolus, Inflammation, Chronic Active, Focal 1 (7%) Perivascular, Infiltration Cellular, Lymphocyte 1 (7%) 2 (13%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM None ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (15) (15) (15) (14) (15) (15) Pelvis, Infiltration Cellular, Focal, Lymphocyte 1 (7%) 2 (13%) Renal Tubule, Dilatation, Focal 4 (27%) 3 (20%) 1 (7%) 2 (13%) 2 (13%) a Number of animals examined microscopically at site and number of animals with lesion Page 4 NTP Experiment-Test: 96003-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/26/01 Route: GAVAGE Time: 13:49:05 ____________________________________________________________________________________________________________________________________ MICE:P53+/-(C57BL/6) MALE VEHICLE 0.5 1 MG/KG 2 MG/KG 4 MG/KG 8 MG/KG CONTROL MG/KG ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 15 15 15 15 15 15 Early Deaths Natural Death 1 1 Moribund Sacrifice 1 Survivors Terminal Sacrifice 15 14 15 15 13 15 Animals Examined Microscopically 15 15 15 15 15 15 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Liver (15) (15) (15) (15) (14) (15) Basophilic Focus 1 (7%) Infiltration Cellular, Focal, Lymphocyte 1 (7%) 2 (13%) Tension Lipidosis 1 (7%) Hepatocyte, Necrosis, Focal 1 (7%) Hepatocyte, Vacuolization Cytoplasmic, Diffuse 5 (33%) 7 (47%) 11 (73%) 7 (47%) 8 (57%) 6 (40%) Hepatocyte, Vacuolization Cytoplasmic, Focal 1 (7%) 1 (7%) Hepatocyte, Periportal, Vacuolization Cytoplasmic 4 (27%) 2 (13%) 2 (13%) 1 (7%) 2 (14%) 2 (13%) Hepatocyte, Centrilobular, Vacuolization Cytoplasmic 3 (20%) 1 (7%) 2 (13%) 2 (14%) 3 (20%) Salivary Glands (1) Infiltration Cellular, Focal, Lymphocyte 1 (100%) Stomach, Forestomach (15) (15) (15) (15) (14) (15) Epithelium, Ulcer, Focal 1 (7%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM None ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (15) (15) (15) (15) (14) (15) Atrophy 1 (7%) 1 (7%) Degeneration, Diffuse 1 (7%) 1 (7%) Hypertrophy, Focal 1 (7%) Subcapsular, Hyperplasia, Focal 1 (7%) 1 (7%) 1 (7%) 1 (7%) 1 (7%) a Number of animals examined microscopically at site and number of animals with lesion Page 5 NTP Experiment-Test: 96003-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/26/01 Route: GAVAGE Time: 13:49:05 ____________________________________________________________________________________________________________________________________ MICE:P53+/-(C57BL/6) MALE VEHICLE 0.5 1 MG/KG 2 MG/KG 4 MG/KG 8 MG/KG CONTROL MG/KG ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - CONT Adrenal Medulla (15) (15) (15) (15) (14) (15) Degeneration, Diffuse 1 (7%) Thyroid Gland (15) (15) (14) (15) (14) (15) Follicular Cell, Hyperplasia, Focal 1 (7%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM Tissue NOS (1) Abdominal, Fat, Necrosis, Focal 1 (100%) ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Epididymis (15) (15) (15) (15) (14) (15) Granuloma Sperm, Focal 1 (7%) Necrosis, Focal 1 (7%) Testes (15) (15) (15) (15) (14) (15) Degeneration, Diffuse 1 (7%) Inflammation, Focal, Granulomatous 1 (7%) Mineralization, Focal 1 (7%) Germinal Epithelium, Degeneration, Diffuse 1 (7%) Germinal Epithelium, Degeneration, Focal 1 (7%) 2 (14%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Lymph Node, Mesenteric (13) (14) (12) (14) (12) (14) Hyperplasia 1 (8%) Spleen (15) (15) (15) (15) (14) (15) Hematopoietic Cell Proliferation 1 (7%) 2 (13%) 2 (13%) 2 (14%) 3 (20%) Pigmentation 1 (7%) 1 (7%) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Skin (15) (15) (15) (15) (14) (15) Epidermis, Control, Hyperplasia, Focal 1 (7%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM None a Number of animals examined microscopically at site and number of animals with lesion Page 6 NTP Experiment-Test: 96003-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: 39 WEEKS ALLYL BROMIDE Date: 03/26/01 Route: GAVAGE Time: 13:49:05 ____________________________________________________________________________________________________________________________________ MICE:P53+/-(C57BL/6) MALE VEHICLE 0.5 1 MG/KG 2 MG/KG 4 MG/KG 8 MG/KG CONTROL MG/KG ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM None ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (15) (15) (15) (15) (15) (15) Alveolar Epithelium, Inflammation, Chronic, Focal 1 (7%) Perivascular, Alveolus, Inflammation, Chronic Active, Focal 1 (7%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM None ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (15) (15) (15) (15) (14) (15) Cyst 1 (7%) Infiltration Cellular, Focal, Lymphocyte 1 (7%) Pelvis, Infiltration Cellular, Focal, Lymphocyte 2 (13%) 2 (13%) 2 (14%) 1 (7%) Renal Tubule, Dilatation, Diffuse 1 (7%) a Number of animals examined microscopically at site and number of animals with lesion Page 7 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------