National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/21017

TDMS Study 96003-05 Pathology Tables

NTP Experiment-Test: 96003-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: 39 WEEKS                                          ALLYL BROMIDE                                       Date: 03/26/01
Route: GAVAGE                                                                                                     Time: 13:49:05

                                                          FINAL#1/MICE




       Facility:  BIORELIANCE

       Chemical CAS #:  106-95-6

       Lock Date:  10/18/00

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 96003-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: 39 WEEKS                                          ALLYL BROMIDE                                       Date: 03/26/01    
Route: GAVAGE                                                                                                     Time: 13:49:05    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         MICE:P53+/-(C57BL/6) FEMALE               VEHICLE      0.5          1 MG/KG      2 MG/KG      4 MG/KG      8 MG/KG         
                                                   CONTROL      MG/KG                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          15           15           15           15           15           15           
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 2            1            2                                      1           
    Natural Death                                                                             1                         1           
  Survivors                                                                                                                         
    Terminal Sacrifice                                13           14           13           14           15           13           
                                                                                                                                    
  Animals Examined Microscopically                    15           15           15           15           15           15           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Small, Duodenum                          (15)         (15)         (15)         (14)         (15)         (14)         
      Polyp Inflammatory, Focal                                                                                         1 (7%)      
   Liver                                              (15)         (15)         (15)         (14)         (15)         (15)         
      Infiltration Cellular, Focal, Lymphocyte         3 (20%)      2 (13%)      4 (27%)      6 (43%)      7 (47%)      2 (13%)     
      Necrosis, Focal                                  1 (7%)                                                                       
      Tension Lipidosis                                                                                                 1 (7%)      
      Hepatocyte, Necrosis, Focal                                                             1 (7%)       1 (7%)       1 (7%)      
      Hepatocyte, Vacuolization Cytoplasmic, Focal                                                         1 (7%)       2 (13%)     
      Hepatocyte, Periportal, Vacuolization                                                                                         
          Cytoplasmic                                  8 (53%)      8 (53%)      8 (53%)      6 (43%)      3 (20%)      5 (33%)     
   Salivary Glands                                                                                                     (1)          
      Infiltration Cellular, Focal, Lymphocyte                                                                          1 (100%)    
   Stomach, Forestomach                               (15)         (15)         (15)         (14)         (15)         (14)         
      Hyperkeratosis, Focal                                                                                1 (7%)                   
      Epithelium, Hyperplasia, Focal                                                                       1 (7%)                   
      Muscularis, Inflammation, Acute, Focal                                                               1 (7%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (15)         (15)         (15)         (14)         (15)         (15)         
      Subcapsular, Hyperplasia, Focal                 13 (87%)     14 (93%)     15 (100%)    12 (86%)     12 (80%)     13 (87%)     
   Parathyroid Gland                                                            (1)                                                 
      Cyst                                                                       1 (100%)                                           
   Pituitary Gland                                    (14)         (14)         (15)         (13)         (15)         (13)         
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    2                                                              
                                                                                                                                   
NTP Experiment-Test: 96003-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: 39 WEEKS                                          ALLYL BROMIDE                                       Date: 03/26/01    
Route: GAVAGE                                                                                                     Time: 13:49:05    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         MICE:P53+/-(C57BL/6) FEMALE               VEHICLE      0.5          1 MG/KG      2 MG/KG      4 MG/KG      8 MG/KG         
                                                   CONTROL      MG/KG                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Cyst, Focal                                                                1 (7%)                                             
   Thyroid Gland                                      (14)         (15)         (15)         (14)         (14)         (15)         
      Ectopic Thymus                                   1 (7%)                                              1 (7%)       1 (7%)      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (15)         (15)         (15)         (14)         (15)         (14)         
      Cyst                                             1 (7%)                                                                       
      Degeneration                                     1 (7%)                                                                       
   Uterus                                             (15)         (15)         (15)         (14)         (15)         (14)         
      Inflammation, Acute                                                                                  1 (7%)                   
      Thrombosis, Focal                                                                                                 1 (7%)      
      Endometrium, Hyperplasia, Cystic                13 (87%)     13 (87%)     14 (93%)     13 (93%)     14 (93%)     14 (100%)    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node                                                      (1)                                    (1)                       
      Hyperplasia                                                                                          1 (100%)                 
   Lymph Node, Mandibular                             (15)         (14)         (15)         (14)         (15)         (13)         
      Hyperplasia                                                                1 (7%)       1 (7%)       1 (7%)                   
   Lymph Node, Mesenteric                             (15)         (14)         (15)         (12)         (15)         (15)         
      Hyperplasia                                                                                          1 (7%)                   
   Lymph Node, Mediastinal                            (15)         (14)         (15)         (14)         (15)         (14)         
      Hyperplasia                                                                1 (7%)                                             
   Spleen                                             (15)         (15)         (15)         (14)         (15)         (15)         
      Hematopoietic Cell Proliferation                 8 (53%)      6 (40%)      7 (47%)     10 (71%)      9 (60%)      7 (47%)     
      Hyperplasia, Lymphoid                            1 (7%)       1 (7%)                                                          
      Pigmentation                                     4 (27%)      8 (53%)      4 (27%)      2 (14%)      2 (13%)      2 (13%)     
      Lymphoid Follicle, Depletion Cellular,                                                                                        
          Diffuse                                                   1 (7%)                                              1 (7%)      
      Lymphoid Follicle, Hyperplasia                                1 (7%)                                                          
   Thymus                                             (14)         (14)         (14)         (14)         (15)         (14)         
      Atrophy, Diffuse                                 1 (7%)                                              2 (13%)      1 (7%)      
      Atrophy, Focal                                                1 (7%)                                              2 (14%)     
      Hyperplasia, Focal                                                         1 (7%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    3                                                              
                                                                                                                                   
NTP Experiment-Test: 96003-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: 39 WEEKS                                          ALLYL BROMIDE                                       Date: 03/26/01    
Route: GAVAGE                                                                                                     Time: 13:49:05    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         MICE:P53+/-(C57BL/6) FEMALE               VEHICLE      0.5          1 MG/KG      2 MG/KG      4 MG/KG      8 MG/KG         
                                                   CONTROL      MG/KG                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (15)         (15)         (15)         (14)         (15)         (15)         
      Epidermis, Hyperplasia, Diffuse                  1 (7%)                                                                       
      Epidermis, Hyperplasia, Focal                                              2 (13%)                   1 (7%)                   
      Subcutaneous Tissue, Edema, Diffuse              1 (7%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (2)          (1)          (1)                                                 
      Metatarsal, Fracture                             1 (50%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (15)         (15)         (15)         (15)         (15)         (15)         
      Alveolar Epithelium, Hyperplasia, Focal                                                 1 (7%)                                
      Alveolus, Inflammation, Chronic Active, Focal                                                        1 (7%)                   
      Perivascular, Infiltration Cellular,                                                                                          
          Lymphocyte                                                                                       1 (7%)       2 (13%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (15)         (15)         (15)         (14)         (15)         (15)         
      Pelvis, Infiltration Cellular, Focal,                                                                                         
          Lymphocyte                                                1 (7%)                                              2 (13%)     
      Renal Tubule, Dilatation, Focal                  4 (27%)                   3 (20%)      1 (7%)       2 (13%)      2 (13%)     
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    4                                                              
                                                                                                                                   
NTP Experiment-Test: 96003-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: 39 WEEKS                                          ALLYL BROMIDE                                       Date: 03/26/01    
Route: GAVAGE                                                                                                     Time: 13:49:05    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         MICE:P53+/-(C57BL/6) MALE                 VEHICLE      0.5          1 MG/KG      2 MG/KG      4 MG/KG      8 MG/KG         
                                                   CONTROL      MG/KG                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          15           15           15           15           15           15           
  Early Deaths                                                                                                                      
    Natural Death                                                   1                                      1                        
    Moribund Sacrifice                                                                                     1                        
  Survivors                                                                                                                         
    Terminal Sacrifice                                15           14           15           15           13           15           
                                                                                                                                    
  Animals Examined Microscopically                    15           15           15           15           15           15           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (15)         (15)         (15)         (15)         (14)         (15)         
      Basophilic Focus                                                                                     1 (7%)                   
      Infiltration Cellular, Focal, Lymphocyte                                   1 (7%)                                 2 (13%)     
      Tension Lipidosis                                                                                                 1 (7%)      
      Hepatocyte, Necrosis, Focal                      1 (7%)                                                                       
      Hepatocyte, Vacuolization Cytoplasmic,                                                                                        
          Diffuse                                      5 (33%)      7 (47%)     11 (73%)      7 (47%)      8 (57%)      6 (40%)     
      Hepatocyte, Vacuolization Cytoplasmic, Focal                                            1 (7%)                    1 (7%)      
      Hepatocyte, Periportal, Vacuolization                                                                                         
          Cytoplasmic                                  4 (27%)      2 (13%)      2 (13%)      1 (7%)       2 (14%)      2 (13%)     
      Hepatocyte, Centrilobular, Vacuolization                                                                                      
          Cytoplasmic                                  3 (20%)      1 (7%)                    2 (13%)      2 (14%)      3 (20%)     
   Salivary Glands                                                                                        (1)                       
      Infiltration Cellular, Focal, Lymphocyte                                                             1 (100%)                 
   Stomach, Forestomach                               (15)         (15)         (15)         (15)         (14)         (15)         
      Epithelium, Ulcer, Focal                                                                1 (7%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (15)         (15)         (15)         (15)         (14)         (15)         
      Atrophy                                                       1 (7%)       1 (7%)                                             
      Degeneration, Diffuse                                                                   1 (7%)                    1 (7%)      
      Hypertrophy, Focal                               1 (7%)                                                                       
      Subcapsular, Hyperplasia, Focal                  1 (7%)       1 (7%)       1 (7%)       1 (7%)                    1 (7%)      
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    5                                                              
                                                                                                                                   
NTP Experiment-Test: 96003-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: 39 WEEKS                                          ALLYL BROMIDE                                       Date: 03/26/01    
Route: GAVAGE                                                                                                     Time: 13:49:05    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         MICE:P53+/-(C57BL/6) MALE                 VEHICLE      0.5          1 MG/KG      2 MG/KG      4 MG/KG      8 MG/KG         
                                                   CONTROL      MG/KG                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
   Adrenal Medulla                                    (15)         (15)         (15)         (15)         (14)         (15)         
      Degeneration, Diffuse                                                                   1 (7%)                                
   Thyroid Gland                                      (15)         (15)         (14)         (15)         (14)         (15)         
      Follicular Cell, Hyperplasia, Focal                                        1 (7%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                                                                (1)                                    
      Abdominal, Fat, Necrosis, Focal                                                         1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (15)         (15)         (15)         (15)         (14)         (15)         
      Granuloma Sperm, Focal                           1 (7%)                                                                       
      Necrosis, Focal                                               1 (7%)                                                          
   Testes                                             (15)         (15)         (15)         (15)         (14)         (15)         
      Degeneration, Diffuse                                                                                             1 (7%)      
      Inflammation, Focal, Granulomatous               1 (7%)                                                                       
      Mineralization, Focal                                         1 (7%)                                                          
      Germinal Epithelium, Degeneration, Diffuse                                                           1 (7%)                   
      Germinal Epithelium, Degeneration, Focal                      1 (7%)                                 2 (14%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node, Mesenteric                             (13)         (14)         (12)         (14)         (12)         (14)         
      Hyperplasia                                                                                          1 (8%)                   
   Spleen                                             (15)         (15)         (15)         (15)         (14)         (15)         
      Hematopoietic Cell Proliferation                              1 (7%)       2 (13%)      2 (13%)      2 (14%)      3 (20%)     
      Pigmentation                                     1 (7%)       1 (7%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (15)         (15)         (15)         (15)         (14)         (15)         
      Epidermis, Control, Hyperplasia, Focal                                                                            1 (7%)      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    6                                                              
                                                                                                                                   
NTP Experiment-Test: 96003-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: 39 WEEKS                                          ALLYL BROMIDE                                       Date: 03/26/01    
Route: GAVAGE                                                                                                     Time: 13:49:05    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         MICE:P53+/-(C57BL/6) MALE                 VEHICLE      0.5          1 MG/KG      2 MG/KG      4 MG/KG      8 MG/KG         
                                                   CONTROL      MG/KG                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (15)         (15)         (15)         (15)         (15)         (15)         
      Alveolar Epithelium, Inflammation, Chronic,                                                                                   
           Focal                                                                              1 (7%)                                
      Perivascular, Alveolus, Inflammation,                                                                                         
          Chronic Active, Focal                        1 (7%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (15)         (15)         (15)         (15)         (14)         (15)         
      Cyst                                                                       1 (7%)                                             
      Infiltration Cellular, Focal, Lymphocyte                                                1 (7%)                                
      Pelvis, Infiltration Cellular, Focal,                                                                                         
          Lymphocyte                                   2 (13%)                   2 (13%)                   2 (14%)      1 (7%)      
      Renal Tubule, Dilatation, Diffuse                                          1 (7%)                                             
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    7                                                              
                                                                                                                                   
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                             ----------              END OF REPORT             ----------                                           
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