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TDMS Study 96003-06 Pathology Tables

NTP Experiment-Test: 96003-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: 39 WEEKS                                          ALLYL BROMIDE                                       Date: 03/26/01
Route: GAVAGE                                                                                                     Time: 13:52:18

                                                          FINAL#1/MICE




       Facility:  BIORELIANCE

       Chemical CAS #:  106-95-6

       Lock Date:  10/18/00

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

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NTP Experiment-Test: 96003-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: 39 WEEKS                                          ALLYL BROMIDE                                       Date: 03/26/01    
Route: GAVAGE                                                                                                     Time: 13:52:18    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         C57BL/6 MICE FEMALE                       VEHICLE      8 MG/KG                                                             
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          15           15                                                               
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                              2                                                               
    Natural Death                                                   1                                                               
  Survivors                                                                                                                         
    Terminal Sacrifice                                15           12                                                               
                                                                                                                                    
  Animals Examined Microscopically                    15           15                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Small, Jejunum                           (15)         (15)                                                             
      Degeneration, Focal                                           1 (7%)                                                          
   Liver                                              (15)         (15)                                                             
      Infiltration Cellular, Focal, Lymphocyte         2 (13%)      6 (40%)                                                         
      Hepatocyte, Periportal, Vacuolization                                                                                         
          Cytoplasmic                                  9 (60%)      6 (40%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (15)         (14)                                                             
      Subcapsular, Hyperplasia, Focal                 14 (93%)     10 (71%)                                                         
   Thyroid Gland                                      (15)         (15)                                                             
      Ectopic Thymus                                                1 (7%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Uterus                                             (15)         (15)                                                             
      Endometrium, Hyperplasia, Cystic                13 (87%)     12 (80%)                                                         
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
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NTP Experiment-Test: 96003-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: 39 WEEKS                                          ALLYL BROMIDE                                       Date: 03/26/01    
Route: GAVAGE                                                                                                     Time: 13:52:18    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         C57BL/6 MICE FEMALE                       VEHICLE      8 MG/KG                                                             
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node                                                      (1)                                                              
      Hyperplasia                                                   1 (100%)                                                        
      Inguinal, Hyperplasia                                         1 (100%)                                                        
   Lymph Node, Mandibular                             (15)         (15)                                                             
      Hyperplasia                                      1 (7%)       3 (20%)                                                         
   Lymph Node, Mediastinal                            (15)         (11)                                                             
      Hyperplasia                                                   1 (9%)                                                          
   Spleen                                             (15)         (14)                                                             
      Hematopoietic Cell Proliferation                 9 (60%)     12 (86%)                                                         
      Pigmentation                                     7 (47%)      4 (29%)                                                         
   Thymus                                             (15)         (14)                                                             
      Atrophy, Diffuse                                              2 (14%)                                                         
      Atrophy, Focal                                                1 (7%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (15)         (15)                                                             
      Epidermis, Ulcer, Chronic Active, Diffuse                     1 (7%)                                                          
      Epidermis, Control, Inflammation, Chronic                                                                                     
          Active, Diffuse                                           1 (7%)                                                          
      Epidermis, Control, Ulcer, Chronic Active,                                                                                    
           Diffuse                                                  1 (7%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (15)         (15)                                                             
      Alveolus, Inflammation, Chronic Active, Focal                 1 (7%)                                                          
      Perivascular, Infiltration Cellular,                                                                                          
          Lymphocyte                                                2 (13%)                                                         
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
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NTP Experiment-Test: 96003-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: 39 WEEKS                                          ALLYL BROMIDE                                       Date: 03/26/01    
Route: GAVAGE                                                                                                     Time: 13:52:18    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         C57BL/6 MICE FEMALE                       VEHICLE      8 MG/KG                                                             
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (15)         (15)                                                             
      Mineralization, Focal                            1 (7%)                                                                       
      Pelvis, Infiltration Cellular, Focal,                                                                                         
          Lymphocyte                                                2 (13%)                                                         
      Renal Tubule, Dilatation, Focal                  2 (13%)      4 (27%)                                                         
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    4                                                              
                                                                                                                                   
NTP Experiment-Test: 96003-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: 39 WEEKS                                          ALLYL BROMIDE                                       Date: 03/26/01    
Route: GAVAGE                                                                                                     Time: 13:52:18    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         C57BL/6 MICE MALE                         VEHICLE      8 MG/KG                                                             
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          15           15                                                               
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 1                                                                            
  Survivors                                                                                                                         
    Terminal Sacrifice                                14           15                                                               
                                                                                                                                    
  Animals Examined Microscopically                    15           15                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (15)         (15)                                                             
      Infiltration Cellular, Focal, Lymphocyte         1 (7%)                                                                       
      Hepatocyte, Vacuolization Cytoplasmic,                                                                                        
          Diffuse                                      4 (27%)      9 (60%)                                                         
      Hepatocyte, Periportal, Vacuolization                                                                                         
          Cytoplasmic                                  2 (13%)      1 (7%)                                                          
      Hepatocyte, Centrilobular, Vacuolization                                                                                      
          Cytoplasmic                                  2 (13%)                                                                      
   Stomach, Forestomach                               (15)         (15)                                                             
      Serosa, Necrosis, Focal                                       1 (7%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (15)         (15)                                                             
      Atrophy                                          4 (27%)      3 (20%)                                                         
      Hypertrophy, Focal                               1 (7%)                                                                       
      Subcapsular, Hyperplasia, Focal                               3 (20%)                                                         
   Thyroid Gland                                      (14)         (15)                                                             
      Follicle, Inflammation, Acute, Focal             1 (7%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    5                                                              
                                                                                                                                   
NTP Experiment-Test: 96003-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: 39 WEEKS                                          ALLYL BROMIDE                                       Date: 03/26/01    
Route: GAVAGE                                                                                                     Time: 13:52:18    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         C57BL/6 MICE MALE                         VEHICLE      8 MG/KG                                                             
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Testes                                             (15)         (15)                                                             
      Germinal Epithelium, Degeneration, Diffuse                    2 (13%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Spleen                                             (15)         (15)                                                             
      Hematopoietic Cell Proliferation                 4 (27%)      1 (7%)                                                          
   Thymus                                             (15)         (15)                                                             
      Atrophy, Diffuse                                 1 (7%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (15)         (15)                                                             
      Perivascular, Infiltration Cellular,                                                                                          
          Lymphocyte                                   1 (7%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    6                                                              
                                                                                                                                   
NTP Experiment-Test: 96003-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: 39 WEEKS                                          ALLYL BROMIDE                                       Date: 03/26/01    
Route: GAVAGE                                                                                                     Time: 13:52:18    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         C57BL/6 MICE MALE                         VEHICLE      8 MG/KG                                                             
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
   Kidney                                             (15)         (15)                                                             
      Pelvis, Infiltration Cellular, Focal,                                                                                         
          Lymphocyte                                   3 (20%)      2 (13%)                                                         
      Renal Tubule, Dilatation, Diffuse                1 (7%)                                                                       
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                      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