TR 341 Mouse Pathology Tables
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Southern Research Inst NITROFURANTOIN DATE: 09/07/94
EXPERIMENT: 05051 TEST: 02 TIME: 14:53:27
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: NOIES28024 ROUTE: DOSED FEED NTP C#: C55196
PATHOLOGIST: H. GILES CAS: 67-20-9
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Southern Research Inst NITROFURANTOIN DATE: 09/07/94
EXPERIMENT: 05051 TEST: 02 TIME: 14:53:27
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: NOIES28024 ROUTE: DOSED FEED NTP C#: C55196
PATHOLOGIST: H. GILES CAS: 67-20-9
MICE(B6C3F1)
----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
----------------
Adrenal Gland
Bone Marrow
Brain
Clitoral Gland
Epididymis
Gallbladder
Heart
Islets, Pancreatic
Kidney
Liver
Lung
Nose
Ovary
Pancreas
Parathyroid Gland
Pituitary Gland
Preputial Gland
Prostate
Salivary Glands
Spleen
Testes
Thymus
Thyroid Gland
Urinary Bladder
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Southern Research Inst NITROFURANTOIN DATE: 09/07/94
EXPERIMENT: 05051 TEST: 02 TIME: 14:53:27
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: NOIES28024 ROUTE: DOSED FEED NTP C#: C55196
PATHOLOGIST: H. GILES CAS: 67-20-9
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF THE STUDY OF NITROFURANTOIN
====================================================================================================
MALE MICE
-------------
ORGAN MORPHOLOGY
------- ------------
Adrenal Medulla Pheochromocytoma: Benign, Complex, Malignant, NOS
Skin: Subcutaneous Tissue Schwannoma Malignant
All Organs Hemangiosarcoma
Hemangiosarcoma or Hemangioma
Malignant Tumors
====================================================================================================
FEMALE MICE
-------------
ORGAN MORPHOLOGY
------- ------------
Adrenal Medulla Pheochromocytoma: Benign, Complex, Malignant, NOS
Liver Hepatocellular Adenoma
Hepatocellular Carcinoma or Hepatocellular Adenoma
Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
Lung Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma
Mammary Gland Carcinoma
Ovary Adenoma
Mixed Tumor Benign
Thyroid Gland: Follicular Cell
Adenoma
Carcinoma or Adenoma
All Organs Hemangiosarcoma
Malignant Lymphoma And Histiocytic Sarcoma
Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed,
NOS, or Undifferentiated Cell Type
Benign Tumors
Malignant Tumors
Malignant and Benign Tumors
====================================================================================================
DATE: 09/07/94 EXPERIMENT: 05051 TEST: 02 PAGE 1
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- NITROFURANTOIN
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | UNTREATD 0.13% 0.25% | UNTREATD 0.13% 0.25% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma Benign |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 4/49 (8%) 0/48 (0%) 1/49 (2%) | 1/48 (2%) 0/49 (0%) 0/49 (0%) |
|ADJUSTED (b) | 13.3% 0.0% 3.0% | 4.8% 0.0% 0.0% |
|TERMINAL (d) | 3/28 (11%) 0/28 (0%) 1/33 (3%) | 0/18 (0%) 0/37 (0%) 0/36 (0%) |
|FIRST INCIDENCE (DAYS) | 688 --- 730 (T) | 728 --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.062N P=0.065N P=0.138N | P=0.183N P=0.387N P=0.372N |
|INCIDENTAL TUMOR | P=0.063N P=0.073N P=0.137N | P=0.323N P=0.581N P=0.557N |
|LOGISTIC REGRESSION | P=0.059N P=0.061N P=0.132N | P=0.193N P=0.392N P=0.391N |
|COCHRAN-ARMITAGE | P=0.079N | P=0.269N |
|FISHER EXACT | P=0.061N P=0.181N | P=0.495N P=0.495N |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma Malignant |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/49 (4%) 0/48 (0%) 0/49 (0%) | 1/48 (2%) 0/49 (0%) 0/49 (0%) |
|ADJUSTED (b) | 6.9% 0.0% 0.0% | 4.0% 0.0% 0.0% |
|TERMINAL (d) | 1/28 (4%) 0/28 (0%) 0/33 (0%) | 0/18 (0%) 0/37 (0%) 0/36 (0%) |
|FIRST INCIDENCE (DAYS) | 714 --- --- | 714 --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.079N P=0.229N P=0.199N | P=0.206N P=0.422N P=0.406N |
|INCIDENTAL TUMOR | P=0.089N P=0.271N P=0.209N | P=0.323N P=0.581N P=0.557N |
|LOGISTIC REGRESSION | P=0.081N P=0.236N P=0.201N | P=0.221N P=0.430N P=0.429N |
|COCHRAN-ARMITAGE | P=0.095N | P=0.269N |
|FISHER EXACT | P=0.253N P=0.247N | P=0.495N P=0.495N |
|=================================================================================================================================|
DATE: 09/07/94 EXPERIMENT: 05051 TEST: 02 PAGE 2
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- NITROFURANTOIN
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | UNTREATD 0.13% 0.25% | UNTREATD 0.13% 0.25% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma: Benign, Complex, Malignant, NOS |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 6/49 (12%) 0/48 (0%) 1/49 (2%) | 2/48 (4%) 0/49 (0%) 0/49 (0%) |
|ADJUSTED (b) | 19.7% 0.0% 3.0% | 8.6% 0.0% 0.0% |
|TERMINAL (d) | 4/28 (14%) 0/28 (0%) 1/33 (3%) | 0/18 (0%) 0/37 (0%) 0/36 (0%) |
|FIRST INCIDENCE (DAYS) | 688 --- 730 (T) | 714 --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.010N* P=0.018N* P=0.038N* | P=0.045N* P=0.142N P=0.128N |
|INCIDENTAL TUMOR | P=0.011N* P=0.023N* P=0.038N* | P=0.135N P=0.328N P=0.300N |
|LOGISTIC REGRESSION | P=0.010N** P=0.016N* P=0.035N* | P=0.051N P=0.145N P=0.145N |
|COCHRAN-ARMITAGE | P=0.015N* | P=0.092N |
|FISHER EXACT | P=0.014N* P=0.056N | P=0.242N P=0.242N |
|=================================================================================================================================|
| |
|Harderian Gland |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 3/50 (6%) 2/50 (4%) | 1/50 (2%) 2/50 (4%) 1/50 (2%) |
|ADJUSTED (b) | 7.1% 9.9% 5.5% | 3.4% 5.4% 2.7% |
|TERMINAL (d) | 2/28 (7%) 2/29 (7%) 1/34 (3%) | 0/19 (0%) 2/37 (5%) 1/37 (3%) |
|FIRST INCIDENCE (DAYS) | 730 (T) 723 694 | 686 730 (T) 730 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.515N P=0.522 P=0.624N | P=0.458N P=0.697 P=0.642N |
|INCIDENTAL TUMOR | P=0.526N P=0.487 P=0.630N | P=0.524N P=0.597 P=0.736N |
|LOGISTIC REGRESSION | P=0.518N P=0.521 P=0.626N | P=0.528N P=0.611 P=0.714N |
|COCHRAN-ARMITAGE | P=0.592 | P=0.620 |
|FISHER EXACT | P=0.500 P=0.691N | P=0.500 P=0.753N |
|=================================================================================================================================|
DATE: 09/07/94 EXPERIMENT: 05051 TEST: 02 PAGE 3
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- NITROFURANTOIN
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | UNTREATD 0.13% 0.25% | UNTREATD 0.13% 0.25% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Harderian Gland |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 3/50 (6%) 2/50 (4%) | 2/50 (4%) 3/50 (6%) 1/50 (2%) |
|ADJUSTED (b) | 7.1% 9.9% 5.5% | 8.5% 8.1% 2.7% |
|TERMINAL (d) | 2/28 (7%) 2/29 (7%) 1/34 (3%) | 1/19 (5%) 3/37 (8%) 1/37 (3%) |
|FIRST INCIDENCE (DAYS) | 730 (T) 723 694 | 686 730 (T) 730 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.515N P=0.522 P=0.624N | P=0.198N P=0.596N P=0.308N |
|INCIDENTAL TUMOR | P=0.526N P=0.487 P=0.630N | P=0.243N P=0.676N P=0.390N |
|LOGISTIC REGRESSION | P=0.518N P=0.521 P=0.626N | P=0.259N P=0.673 P=0.384N |
|COCHRAN-ARMITAGE | P=0.592 | P=0.411N |
|FISHER EXACT | P=0.500 P=0.691N | P=0.500 P=0.500N |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 5/50 (10%) 4/50 (8%) | 1/50 (2%) 1/50 (2%) 7/50 (14%) |
|ADJUSTED (b) | 7.1% 17.2% 11.4% | 2.7% 2.7% 18.1% |
|TERMINAL (d) | 2/28 (7%) 5/29 (17%) 3/34 (9%) | 0/19 (0%) 1/37 (3%) 6/37 (16%) |
|FIRST INCIDENCE (DAYS) | 730 (T) 730 (T) 729 | 603 730 (T) 660 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.380 P=0.226 P=0.434 | P=0.042 * P=0.658N P=0.147 |
|INCIDENTAL TUMOR | P=0.374 P=0.226 P=0.424 | P=0.024 * P=0.761 P=0.080 |
|LOGISTIC REGRESSION | P=0.400 P=0.226 P=0.448 | P=0.016 * P=0.758 P=0.054 |
|COCHRAN-ARMITAGE | P=0.278 | P=0.012 * |
|FISHER EXACT | P=0.218 P=0.339 | P=0.753N P=0.030 * |
|=================================================================================================================================|
DATE: 09/07/94 EXPERIMENT: 05051 TEST: 02 PAGE 4
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- NITROFURANTOIN
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | UNTREATD 0.13% 0.25% | UNTREATD 0.13% 0.25% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 9/50 (18%) 7/50 (14%) 7/50 (14%) | 1/50 (2%) 1/50 (2%) 2/50 (4%) |
|ADJUSTED (b) | 26.6% 20.2% 17.3% | 4.0% 2.2% 5.0% |
|TERMINAL (d) | 5/28 (18%) 4/29 (14%) 3/34 (9%) | 0/19 (0%) 0/37 (0%) 1/37 (3%) |
|FIRST INCIDENCE (DAYS) | 611 496 602 | 714 670 678 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.220N P=0.380N P=0.263N | P=0.532 P=0.665N P=0.672 |
|INCIDENTAL TUMOR | P=0.187N P=0.214N P=0.170N | P=0.336 P=0.652 P=0.490 |
|LOGISTIC REGRESSION | P=0.160N P=0.254N P=0.189N | P=0.406 P=0.750N P=0.587 |
|COCHRAN-ARMITAGE | P=0.338N | P=0.386 |
|FISHER EXACT | P=0.393N P=0.393N | P=0.753N P=0.500 |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma or Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 10/50 (20%) 12/50 (24%) 11/50 (22%) | 2/50 (4%) 2/50 (4%) 8/50 (16%) |
|ADJUSTED (b) | 29.8% 36.2% 27.4% | 6.6% 4.9% 20.0% |
|TERMINAL (d) | 6/28 (21%) 9/29 (31%) 6/34 (18%) | 0/19 (0%) 1/37 (3%) 6/37 (16%) |
|FIRST INCIDENCE (DAYS) | 611 496 602 | 603 670 660 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.449N P=0.433 P=0.503N | P=0.093 P=0.531N P=0.217 |
|INCIDENTAL TUMOR | P=0.435N P=0.587 P=0.419N | P=0.032 * P=0.597 P=0.083 |
|LOGISTIC REGRESSION | P=0.499N P=0.445 P=0.551N | P=0.029 * P=0.704N P=0.079 |
|COCHRAN-ARMITAGE | P=0.450 | P=0.023 * |
|FISHER EXACT | P=0.405 P=0.500 | P=0.691N P=0.046 * |
|=================================================================================================================================|
DATE: 09/07/94 EXPERIMENT: 05051 TEST: 02 PAGE 5
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- NITROFURANTOIN
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | UNTREATD 0.13% 0.25% | UNTREATD 0.13% 0.25% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 10/50 (20%) 12/50 (24%) 11/50 (22%) | 2/50 (4%) 2/50 (4%) 8/50 (16%) |
|ADJUSTED (b) | 29.8% 36.2% 27.4% | 6.6% 4.9% 20.0% |
|TERMINAL (d) | 6/28 (21%) 9/29 (31%) 6/34 (18%) | 0/19 (0%) 1/37 (3%) 6/37 (16%) |
|FIRST INCIDENCE (DAYS) | 611 496 602 | 603 670 660 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.449N P=0.433 P=0.503N | P=0.093 P=0.531N P=0.217 |
|INCIDENTAL TUMOR | P=0.435N P=0.587 P=0.419N | P=0.032 * P=0.597 P=0.083 |
|LOGISTIC REGRESSION | P=0.499N P=0.445 P=0.551N | P=0.029 * P=0.704N P=0.079 |
|COCHRAN-ARMITAGE | P=0.450 | P=0.023 * |
|FISHER EXACT | P=0.405 P=0.500 | P=0.691N P=0.046 * |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 5/50 (10%) 2/50 (4%) 4/50 (8%) | 2/50 (4%) 2/50 (4%) 0/50 (0%) |
|ADJUSTED (b) | 15.0% 6.4% 11.8% | 7.8% 5.4% 0.0% |
|TERMINAL (d) | 2/28 (7%) 1/29 (3%) 4/34 (12%) | 1/19 (5%) 2/37 (5%) 0/37 (0%) |
|FIRST INCIDENCE (DAYS) | 611 699 730 (T) | 603 730 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.328N P=0.214N P=0.394N | P=0.079N P=0.482N P=0.143N |
|INCIDENTAL TUMOR | P=0.304N P=0.188N P=0.346N | P=0.126N P=0.590N P=0.239N |
|LOGISTIC REGRESSION | P=0.325N P=0.200N P=0.397N | P=0.153N P=0.646N P=0.245N |
|COCHRAN-ARMITAGE | P=0.417N | P=0.184N |
|FISHER EXACT | P=0.218N P=0.500N | P=0.691N P=0.247N |
|=================================================================================================================================|
DATE: 09/07/94 EXPERIMENT: 05051 TEST: 02 PAGE 6
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- NITROFURANTOIN
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | UNTREATD 0.13% 0.25% | UNTREATD 0.13% 0.25% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 2/50 (4%) 3/50 (6%) | 1/50 (2%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 3.6% 6.9% 7.7% | 2.4% 0.0% 0.0% |
|TERMINAL (d) | 1/28 (4%) 2/29 (7%) 1/34 (3%) | 0/19 (0%) 0/37 (0%) 0/37 (0%) |
|FIRST INCIDENCE (DAYS) | 730 (T) 730 (T) 602 | 561 --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.296 P=0.512 P=0.384 | P=0.243N P=0.464N P=0.460N |
|INCIDENTAL TUMOR | P=0.312 P=0.512 P=0.435 | P=0.407N P=0.662N P=0.662N |
|LOGISTIC REGRESSION | P=0.280 P=0.512 P=0.352 | P=0.405N P=0.643N P=0.665N |
|COCHRAN-ARMITAGE | P=0.225 | P=0.272N |
|FISHER EXACT | P=0.500 P=0.309 | P=0.500N P=0.500N |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 6/50 (12%) 4/50 (8%) 7/50 (14%) | 3/50 (6%) 2/50 (4%) 0/50 (0%) |
|ADJUSTED (b) | 18.3% 13.1% 18.9% | 10.1% 5.4% 0.0% |
|TERMINAL (d) | 3/28 (11%) 3/29 (10%) 5/34 (15%) | 1/19 (5%) 2/37 (5%) 0/37 (0%) |
|FIRST INCIDENCE (DAYS) | 611 699 602 | 561 730 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.549N P=0.356N P=0.592N | P=0.030N* P=0.292N P=0.065N |
|INCIDENTAL TUMOR | P=0.516N P=0.338N P=0.523N | P=0.075N P=0.462N P=0.161N |
|LOGISTIC REGRESSION | P=0.560N P=0.343N P=0.618N | P=0.099N P=0.526N P=0.161N |
|COCHRAN-ARMITAGE | P=0.448 | P=0.085N |
|FISHER EXACT | P=0.370N P=0.500 | P=0.500N P=0.121N |
|=================================================================================================================================|
DATE: 09/07/94 EXPERIMENT: 05051 TEST: 02 PAGE 7
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- NITROFURANTOIN
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | UNTREATD 0.13% 0.25% | UNTREATD 0.13% 0.25% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Mammary Gland |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 0/50 (0%) | 5/50 (10%) 3/50 (6%) 1/50 (2%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% | 19.6% 7.2% 2.7% |
|TERMINAL (d) | 0/28 (0%) 0/29 (0%) 0/34 (0%) | 2/19 (11%) 1/37 (3%) 1/37 (3%) |
|FIRST INCIDENCE (DAYS) | --- --- --- | 635 596 730 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) | P=0.016N* P=0.144N P=0.026N* |
|INCIDENTAL TUMOR | (e) (e) (e) | P=0.081N P=0.426N P=0.081N |
|LOGISTIC REGRESSION | (e) (e) (e) | P=0.053N P=0.301N P=0.056N |
|COCHRAN-ARMITAGE | (e) | P=0.071N |
|FISHER EXACT | (e) (e) | P=0.357N P=0.102N |
|=================================================================================================================================|
| |
|Ovary |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | | 0/50 (0%) 0/50 (0%) 5/50 (10%) |
|ADJUSTED (b) | | 0.0% 0.0% 13.0% |
|TERMINAL (d) | | 0/19 (0%) 0/37 (0%) 4/37 (11%) |
|FIRST INCIDENCE (DAYS) | | --- --- 729 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.019 * (e) P=0.127 |
|INCIDENTAL TUMOR | | P=0.013 * (e) P=0.083 |
|LOGISTIC REGRESSION | | P=0.018 * (e) P=0.112 |
|COCHRAN-ARMITAGE | | P=0.007 ** |
|FISHER EXACT | | (e) P=0.028 * |
|=================================================================================================================================|
DATE: 09/07/94 EXPERIMENT: 05051 TEST: 02 PAGE 8
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- NITROFURANTOIN
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | UNTREATD 0.13% 0.25% | UNTREATD 0.13% 0.25% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Ovary |
| Cystadenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | | 2/50 (4%) 1/50 (2%) 1/50 (2%) |
|ADJUSTED (b) | | 8.4% 2.7% 2.4% |
|TERMINAL (d) | | 1/19 (5%) 1/37 (3%) 0/37 (0%) |
|FIRST INCIDENCE (DAYS) | | 667 730 (T) 708 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.227N P=0.305N P=0.333N |
|INCIDENTAL TUMOR | | P=0.349N P=0.403N P=0.510N |
|LOGISTIC REGRESSION | | P=0.309N P=0.411N P=0.434N |
|COCHRAN-ARMITAGE | | P=0.380N |
|FISHER EXACT | | P=0.500N P=0.500N |
|=================================================================================================================================|
| |
|Ovary |
| Granulosa Cell Tumor Benign |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | | 0/50 (0%) 3/50 (6%) 1/50 (2%) |
|ADJUSTED (b) | | 0.0% 8.1% 2.7% |
|TERMINAL (d) | | 0/19 (0%) 3/37 (8%) 1/37 (3%) |
|FIRST INCIDENCE (DAYS) | | --- 730 (T) 730 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.564 P=0.260 P=0.633 |
|INCIDENTAL TUMOR | | P=0.564 P=0.260 P=0.633 |
|LOGISTIC REGRESSION | | P=0.564 P=0.258 P=0.633 |
|COCHRAN-ARMITAGE | | P=0.367 |
|FISHER EXACT | | P=0.121 P=0.500 |
|=================================================================================================================================|
DATE: 09/07/94 EXPERIMENT: 05051 TEST: 02 PAGE 9
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- NITROFURANTOIN
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | UNTREATD 0.13% 0.25% | UNTREATD 0.13% 0.25% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Ovary |
| Granulosa Cell Tumor, Benign, Malignant, NOS |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | | 0/50 (0%) 3/50 (6%) 2/50 (4%) |
|ADJUSTED (b) | | 0.0% 8.1% 5.1% |
|TERMINAL (d) | | 0/19 (0%) 3/37 (8%) 1/37 (3%) |
|FIRST INCIDENCE (DAYS) | | --- 730 (T) 729 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.375 P=0.260 P=0.404 |
|INCIDENTAL TUMOR | | P=0.301 P=0.260 P=0.264 |
|LOGISTIC REGRESSION | | P=0.362 P=0.258 P=0.374 |
|COCHRAN-ARMITAGE | | P=0.197 |
|FISHER EXACT | | P=0.121 P=0.247 |
|=================================================================================================================================|
| |
|Ovary |
| Mixed Tumor Benign |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | | 0/50 (0%) 0/50 (0%) 4/50 (8%) |
|ADJUSTED (b) | | 0.0% 0.0% 10.0% |
|TERMINAL (d) | | 0/19 (0%) 0/37 (0%) 3/37 (8%) |
|FIRST INCIDENCE (DAYS) | | --- --- 630 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.035 * (e) P=0.162 |
|INCIDENTAL TUMOR | | P=0.020 * (e) P=0.096 |
|LOGISTIC REGRESSION | | P=0.018 * (e) P=0.084 |
|COCHRAN-ARMITAGE | | P=0.017 * |
|FISHER EXACT | | (e) P=0.059 |
|=================================================================================================================================|
DATE: 09/07/94 EXPERIMENT: 05051 TEST: 02 PAGE 10
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- NITROFURANTOIN
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | UNTREATD 0.13% 0.25% | UNTREATD 0.13% 0.25% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/46 (0%) 0/48 (0%) 0/43 (0%) | 3/48 (6%) 1/44 (2%) 2/49 (4%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% | 16.7% 2.9% 4.7% |
|TERMINAL (d) | 0/26 (0%) 0/28 (0%) 0/28 (0%) | 3/18 (17%) 1/35 (3%) 0/36 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- | 730 (T) 730 (T) 656 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) | P=0.178N P=0.107N P=0.229N |
|INCIDENTAL TUMOR | (e) (e) (e) | P=0.281N P=0.107N P=0.367N |
|LOGISTIC REGRESSION | (e) (e) (e) | P=0.256N P=0.107N P=0.330N |
|COCHRAN-ARMITAGE | (e) | P=0.390N |
|FISHER EXACT | (e) (e) | P=0.342N P=0.490N |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Fibroma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 2/50 (4%) 3/50 (6%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 2.9% 6.9% 8.4% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/28 (0%) 2/29 (7%) 2/34 (6%) | 0/19 (0%) 0/37 (0%) 0/37 (0%) |
|FIRST INCIDENCE (DAYS) | 688 730 (T) 695 | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.285 P=0.505 P=0.366 | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.285 P=0.475 P=0.362 | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.287 P=0.513 P=0.367 | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.225 | (e) |
|FISHER EXACT | P=0.500 P=0.309 | (e) (e) |
|=================================================================================================================================|
DATE: 09/07/94 EXPERIMENT: 05051 TEST: 02 PAGE 11
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- NITROFURANTOIN
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | UNTREATD 0.13% 0.25% | UNTREATD 0.13% 0.25% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Fibrosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 9/50 (18%) 5/50 (10%) 12/50 (24%) | 0/50 (0%) 1/50 (2%) 1/50 (2%) |
|ADJUSTED (b) | 25.8% 12.8% 27.0% | 0.0% 2.3% 2.7% |
|TERMINAL (d) | 4/28 (14%) 0/29 (0%) 4/34 (12%) | 0/19 (0%) 0/37 (0%) 1/37 (3%) |
|FIRST INCIDENCE (DAYS) | 408 335 575 | --- 694 730 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.429 P=0.192N P=0.495 | P=0.440 P=0.593 P=0.633 |
|INCIDENTAL TUMOR | P=0.311 P=0.269N P=0.444 | P=0.351 P=0.403 P=0.633 |
|LOGISTIC REGRESSION | P=0.259 P=0.190N P=0.336 | P=0.380 P=0.524 P=0.633 |
|COCHRAN-ARMITAGE | P=0.269 | P=0.334 |
|FISHER EXACT | P=0.194N P=0.312 | P=0.500 P=0.500 |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Neurofibrosarcoma, Fibrosarcoma, Sarcoma, |
| Neurofibroma, or Fibroma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 10/50 (20%) 7/50 (14%) 14/50 (28%) | 0/50 (0%) 1/50 (2%) 1/50 (2%) |
|ADJUSTED (b) | 28.0% 18.8% 31.9% | 0.0% 2.3% 2.7% |
|TERMINAL (d) | 4/28 (14%) 2/29 (7%) 6/34 (18%) | 0/19 (0%) 0/37 (0%) 1/37 (3%) |
|FIRST INCIDENCE (DAYS) | 408 335 575 | --- 694 730 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.372 P=0.289N P=0.433 | P=0.440 P=0.593 P=0.633 |
|INCIDENTAL TUMOR | P=0.261 P=0.399N P=0.372 | P=0.351 P=0.403 P=0.633 |
|LOGISTIC REGRESSION | P=0.225 P=0.285N P=0.282 | P=0.380 P=0.524 P=0.633 |
|COCHRAN-ARMITAGE | P=0.204 | P=0.334 |
|FISHER EXACT | P=0.298N P=0.241 | P=0.500 P=0.500 |
|=================================================================================================================================|
DATE: 09/07/94 EXPERIMENT: 05051 TEST: 02 PAGE 12
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- NITROFURANTOIN
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | UNTREATD 0.13% 0.25% | UNTREATD 0.13% 0.25% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Schwannoma Malignant |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 3/50 (6%) 0/50 (0%) 0/50 (0%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 8.8% 0.0% 0.0% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 1/28 (4%) 0/29 (0%) 0/34 (0%) | 0/19 (0%) 0/37 (0%) 0/37 (0%) |
|FIRST INCIDENCE (DAYS) | 533 --- --- | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.029N* P=0.119N P=0.096N | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.060N P=0.181N P=0.180N | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.033N* P=0.117N P=0.114N | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.036N* | (e) |
|FISHER EXACT | P=0.121N P=0.121N | (e) (e) |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Squamous Cell Carcinoma or Papilloma Squamous |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 0/50 (0%) 0/50 (0%) | 2/50 (4%) 0/50 (0%) 1/50 (2%) |
|ADJUSTED (b) | 3.6% 0.0% 0.0% | 7.4% 0.0% 2.7% |
|TERMINAL (d) | 1/28 (4%) 0/29 (0%) 0/34 (0%) | 1/19 (5%) 0/37 (0%) 1/37 (3%) |
|FIRST INCIDENCE (DAYS) | 730 (T) --- --- | 521 --- 730 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.248N P=0.493N P=0.461N | P=0.236N P=0.159N P=0.335N |
|INCIDENTAL TUMOR | P=0.248N P=0.493N P=0.461N | P=0.495N P=0.316N P=0.606N |
|LOGISTIC REGRESSION | P=0.248N P=0.493N P=0.461N | P=0.426N P=0.295N P=0.558N |
|COCHRAN-ARMITAGE | P=0.272N | P=0.355N |
|FISHER EXACT | P=0.500N P=0.500N | P=0.247N P=0.500N |
|=================================================================================================================================|
DATE: 09/07/94 EXPERIMENT: 05051 TEST: 02 PAGE 13
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- NITROFURANTOIN
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | UNTREATD 0.13% 0.25% | UNTREATD 0.13% 0.25% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/48 (4%) 0/47 (0%) 0/48 (0%) | 3/48 (6%) 1/49 (2%) 0/50 (0%) |
|ADJUSTED (b) | 6.0% 0.0% 0.0% | 12.3% 2.8% 0.0% |
|TERMINAL (d) | 1/28 (4%) 0/28 (0%) 0/33 (0%) | 1/19 (5%) 1/36 (3%) 0/37 (0%) |
|FIRST INCIDENCE (DAYS) | 473 --- --- | 635 730 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.080N P=0.229N P=0.200N | P=0.018N* P=0.146N P=0.047N* |
|INCIDENTAL TUMOR | P=0.166N P=0.336N P=0.369N | P=0.058N P=0.291N P=0.138N |
|LOGISTIC REGRESSION | P=0.102N P=0.246N P=0.274N | P=0.039N* P=0.233N P=0.087N |
|COCHRAN-ARMITAGE | P=0.095N | P=0.057N |
|FISHER EXACT | P=0.253N P=0.247N | P=0.301N P=0.114N |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/48 (4%) 0/47 (0%) 0/48 (0%) | 4/48 (8%) 1/49 (2%) 0/50 (0%) |
|ADJUSTED (b) | 6.0% 0.0% 0.0% | 17.2% 2.8% 0.0% |
|TERMINAL (d) | 1/28 (4%) 0/28 (0%) 0/33 (0%) | 2/19 (11%) 1/36 (3%) 0/37 (0%) |
|FIRST INCIDENCE (DAYS) | 473 --- --- | 635 730 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.080N P=0.229N P=0.200N | P=0.005N** P=0.058N P=0.016N* |
|INCIDENTAL TUMOR | P=0.166N P=0.336N P=0.369N | P=0.017N* P=0.132N P=0.050N |
|LOGISTIC REGRESSION | P=0.102N P=0.246N P=0.274N | P=0.012N* P=0.109N P=0.033N* |
|COCHRAN-ARMITAGE | P=0.095N | P=0.023N* |
|FISHER EXACT | P=0.253N P=0.247N | P=0.175N P=0.054N |
|=================================================================================================================================|
DATE: 09/07/94 EXPERIMENT: 05051 TEST: 02 PAGE 14
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- NITROFURANTOIN
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | UNTREATD 0.13% 0.25% | UNTREATD 0.13% 0.25% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Uterus |
| Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # |
|----------- | | |
|OVERALL (a) | | 2/50 (4%) 2/50 (4%) 1/50 (2%) |
|ADJUSTED (b) | | 9.6% 5.4% 2.7% |
|TERMINAL (d) | | 1/19 (5%) 2/37 (5%) 1/37 (3%) |
|FIRST INCIDENCE (DAYS) | | 722 730 (T) 730 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.194N P=0.454N P=0.284N |
|INCIDENTAL TUMOR | | P=0.256N P=0.558N P=0.390N |
|LOGISTIC REGRESSION | | P=0.223N P=0.510N P=0.328N |
|COCHRAN-ARMITAGE | | P=0.397N |
|FISHER EXACT | | P=0.691N P=0.500N |
|=================================================================================================================================|
| |
|Uterus |
| Sarcoma Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # |
|----------- | | |
|OVERALL (a) | | 0/50 (0%) 0/50 (0%) 2/50 (4%) |
|ADJUSTED (b) | | 0.0% 0.0% 5.1% |
|TERMINAL (d) | | 0/19 (0%) 0/37 (0%) 1/37 (3%) |
|FIRST INCIDENCE (DAYS) | | --- --- 729 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.164 (e) P=0.404 |
|INCIDENTAL TUMOR | | P=0.109 (e) P=0.264 |
|LOGISTIC REGRESSION | | P=0.152 (e) P=0.374 |
|COCHRAN-ARMITAGE | | P=0.103 |
|FISHER EXACT | | (e) P=0.247 |
|=================================================================================================================================|
DATE: 09/07/94 EXPERIMENT: 05051 TEST: 02 PAGE 15
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- NITROFURANTOIN
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | UNTREATD 0.13% 0.25% | UNTREATD 0.13% 0.25% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Uterus |
| Sarcoma Stromal or Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # |
|----------- | | |
|OVERALL (a) | | 2/50 (4%) 2/50 (4%) 3/50 (6%) |
|ADJUSTED (b) | | 9.6% 5.4% 7.8% |
|TERMINAL (d) | | 1/19 (5%) 2/37 (5%) 2/37 (5%) |
|FIRST INCIDENCE (DAYS) | | 722 730 (T) 729 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.525N P=0.454N P=0.574N |
|INCIDENTAL TUMOR | | P=0.548 P=0.558N P=0.612 |
|LOGISTIC REGRESSION | | P=0.571N P=0.510N P=0.639N |
|COCHRAN-ARMITAGE | | P=0.412 |
|FISHER EXACT | | P=0.691N P=0.500 |
|=================================================================================================================================|
| |
|All Organs |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 3/50 (6%) 1/50 (2%) 0/50 (0%) | 2/50 (4%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 9.6% 2.3% 0.0% | 9.8% 0.0% 0.0% |
|TERMINAL (d) | 2/28 (7%) 0/29 (0%) 0/34 (0%) | 1/19 (5%) 0/37 (0%) 0/37 (0%) |
|FIRST INCIDENCE (DAYS) | 611 530 --- | 728 --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.047N* P=0.293N P=0.092N | P=0.038N* P=0.118N P=0.112N |
|INCIDENTAL TUMOR | P=0.059N P=0.252N P=0.057N | P=0.083N P=0.212N P=0.202N |
|LOGISTIC REGRESSION | P=0.057N P=0.298N P=0.099N | P=0.042N* P=0.131N P=0.123N |
|COCHRAN-ARMITAGE | P=0.061N | P=0.095N |
|FISHER EXACT | P=0.309N P=0.121N | P=0.247N P=0.247N |
|=================================================================================================================================|
DATE: 09/07/94 EXPERIMENT: 05051 TEST: 02 PAGE 16
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- NITROFURANTOIN
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | UNTREATD 0.13% 0.25% | UNTREATD 0.13% 0.25% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|All Organs |
| Hemangiosarcoma or Hemangioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 3/50 (6%) 1/50 (2%) 0/50 (0%) | 3/50 (6%) 1/50 (2%) 1/50 (2%) |
|ADJUSTED (b) | 9.6% 2.3% 0.0% | 14.8% 2.7% 2.7% |
|TERMINAL (d) | 2/28 (7%) 0/29 (0%) 0/34 (0%) | 2/19 (11%) 1/37 (3%) 1/37 (3%) |
|FIRST INCIDENCE (DAYS) | 611 530 --- | 728 730 (T) 730 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.047N* P=0.293N P=0.092N | P=0.067N P=0.116N P=0.112N |
|INCIDENTAL TUMOR | P=0.059N P=0.252N P=0.057N | P=0.102N P=0.179N P=0.172N |
|LOGISTIC REGRESSION | P=0.057N P=0.298N P=0.099N | P=0.072N P=0.134N P=0.120N |
|COCHRAN-ARMITAGE | P=0.061N | P=0.201N |
|FISHER EXACT | P=0.309N P=0.121N | P=0.309N P=0.309N |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Lymphoma And Histiocytic Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 5/50 (10%) 3/50 (6%) 6/50 (12%) | 12/50 (24%) 19/50 (38%) 24/50 (48%) |
|ADJUSTED (b) | 16.4% 9.0% 15.3% | 50.2% 43.4% 52.7% |
|TERMINAL (d) | 3/28 (11%) 1/29 (3%) 3/34 (9%) | 8/19 (42%) 13/37 (35%) 16/37 (43%) |
|FIRST INCIDENCE (DAYS) | 697 605 527 | 631 596 568 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.567 P=0.336N P=0.614N | P=0.352 P=0.447N P=0.449 |
|INCIDENTAL TUMOR | P=0.495 P=0.325N P=0.513 | P=0.039 * P=0.304 P=0.075 |
|LOGISTIC REGRESSION | P=0.535 P=0.333N P=0.601 | P=0.038 * P=0.295 P=0.076 |
|COCHRAN-ARMITAGE | P=0.444 | P=0.008 ** |
|FISHER EXACT | P=0.357N P=0.500 | P=0.097 P=0.011 * |
|=================================================================================================================================|
DATE: 09/07/94 EXPERIMENT: 05051 TEST: 02 PAGE 17
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- NITROFURANTOIN
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | UNTREATD 0.13% 0.25% | UNTREATD 0.13% 0.25% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed, |
| NOS, or Undifferentiated Cell Type |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 5/50 (10%) 3/50 (6%) 6/50 (12%) | 12/50 (24%) 19/50 (38%) 24/50 (48%) |
|ADJUSTED (b) | 16.4% 9.0% 15.3% | 50.2% 43.4% 52.7% |
|TERMINAL (d) | 3/28 (11%) 1/29 (3%) 3/34 (9%) | 8/19 (42%) 13/37 (35%) 16/37 (43%) |
|FIRST INCIDENCE (DAYS) | 697 605 527 | 631 596 568 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.567 P=0.336N P=0.614N | P=0.352 P=0.447N P=0.449 |
|INCIDENTAL TUMOR | P=0.495 P=0.325N P=0.513 | P=0.039 * P=0.304 P=0.075 |
|LOGISTIC REGRESSION | P=0.535 P=0.333N P=0.601 | P=0.038 * P=0.295 P=0.076 |
|COCHRAN-ARMITAGE | P=0.444 | P=0.008 ** |
|FISHER EXACT | P=0.357N P=0.500 | P=0.097 P=0.011 * |
|=================================================================================================================================|
| |
|All Organs |
| Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 12/50 (24%) 11/50 (22%) 14/50 (28%) | 15/50 (30%) 15/50 (30%) 22/50 (44%) |
|ADJUSTED (b) | 36.2% 35.3% 37.7% | 57.9% 39.1% 50.8% |
|TERMINAL (d) | 8/28 (29%) 9/29 (31%) 11/34 (32%) | 9/19 (47%) 14/37 (38%) 16/37 (43%) |
|FIRST INCIDENCE (DAYS) | 473 699 694 | 603 575 630 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.510N P=0.460N P=0.551N | P=0.327N P=0.039N* P=0.283N |
|INCIDENTAL TUMOR | P=0.538 P=0.505N P=0.578 | P=0.397 P=0.154N P=0.433 |
|LOGISTIC REGRESSION | P=0.517N P=0.455N P=0.575N | P=0.365 P=0.219N P=0.461 |
|COCHRAN-ARMITAGE | P=0.370 | P=0.090 |
|FISHER EXACT | P=0.500N P=0.410 | P=0.586N P=0.107 |
|=================================================================================================================================|
DATE: 09/07/94 EXPERIMENT: 05051 TEST: 02 PAGE 18
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- NITROFURANTOIN
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | UNTREATD 0.13% 0.25% | UNTREATD 0.13% 0.25% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 28/50 (56%) 20/50 (40%) 24/50 (48%) | 21/50 (42%) 27/50 (54%) 31/50 (62%) |
|ADJUSTED (b) | 68.2% 48.8% 49.9% | 70.5% 57.3% 64.5% |
|TERMINAL (d) | 15/28 (54%) 9/29 (31%) 10/34 (29%) | 11/19 (58%) 17/37 (46%) 20/37 (54%) |
|FIRST INCIDENCE (DAYS) | 408 335 527 | 521 596 568 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.098N P=0.103N P=0.112N | P=0.298N P=0.155N P=0.271N |
|INCIDENTAL TUMOR | P=0.098N P=0.055N P=0.057N | P=0.073 P=0.317 P=0.133 |
|LOGISTIC REGRESSION | P=0.102N P=0.040N* P=0.059N | P=0.120 P=0.434 P=0.192 |
|COCHRAN-ARMITAGE | P=0.233N | P=0.028 * |
|FISHER EXACT | P=0.080N P=0.274N | P=0.158 P=0.036 * |
|=================================================================================================================================|
| |
|All Organs |
| Malignant and Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 31/50 (62%) 27/50 (54%) 33/50 (66%) | 30/50 (60%) 35/50 (70%) 41/50 (82%) |
|ADJUSTED (b) | 73.8% 65.3% 68.7% | 90.4% 72.8% 82.0% |
|TERMINAL (d) | 17/28 (61%) 15/29 (52%) 19/34 (56%) | 16/19 (84%) 24/37 (65%) 28/37 (76%) |
|FIRST INCIDENCE (DAYS) | 408 335 527 | 521 575 568 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.299N P=0.263N P=0.323N | P=0.121N P=0.025N* P=0.090N |
|INCIDENTAL TUMOR | P=0.472N P=0.254N P=0.418N | P=0.106 P=0.577N P=0.202 |
|LOGISTIC REGRESSION | P=0.435N P=0.173N P=0.406N | P=0.121 P=0.504N P=0.243 |
|COCHRAN-ARMITAGE | P=0.391 | P=0.011 * |
|FISHER EXACT | P=0.272N P=0.418 | P=0.201 P=0.013 * |
|=================================================================================================================================|
DATE: 09/07/94 EXPERIMENT: 05051 TEST: 02 PAGE 19
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- NITROFURANTOIN
TERMINAL SACRIFICE AT 105 WEEKS
(a) Number of tumor-bearing animals / number of animals examined at site.
(b) Kaplan-Meier estimated lifetime tumor incidence after adjustment for
intercurrent mortality.
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death. The incidental tumor
test regards these lesions as non-fatal. Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fisher's exact tests compare directly the overall incidence rates.
For all tests, a negative trend is indicated by "N".
(e) Value of Statistic cannot be computed.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
* To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).
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