National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/2645

TR 341 Rat Pathology Tables


                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                           NITROFURANTOIN


NTP Experiment-Test: 05051-01                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/07/94
Route: DOSED FEED                                                                                                 Time: 07:01:33




       Facility:  Southern Research Institute

       Chemical CAS #:  67-20-9

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05051-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           NITROFURANTOIN                                      Date: 09/07/94  
Route: DOSED FEED                                                                                                 Time: 07:01:33  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   UNTREATD     0.06%        0.13%                                                  
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Moribund                                          22           12           17                                                  
    Dead                                               3           12            2                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                25           26           31                                                  
  Animals Examined Microscopically                    50           50           50                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (50)         (50)         (50)                                                
      Neoplastic Nodule                                             1 (2%)                                                          
      Osteosarcoma, Metastatic, Bone                                             1 (2%)                                             
      Sarcoma Stromal, Metastatic, Uterus              1 (2%)                                                                       
   Mesentery                                          (8)          (9)          (10)                                                
      Sarcoma Stromal, Metastatic, Uterus              1 (13%)                                                                      
   Pancreas                                           (50)         (48)         (49)                                                
      Sarcoma Stromal, Metastatic, Uterus              1 (2%)                                                                       
      Acinus, Adenoma                                               1 (2%)                                                          
   Salivary Glands                                    (49)         (49)         (50)                                                
      Adenocarcinoma                                                             1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (49)         (50)                                                
      Adenoma                                                       2 (4%)       1 (2%)                                             
   Adrenal Gland, Medulla                             (48)         (48)         (50)                                                
      Pheochromocytoma Malignant                                                 1 (2%)                                             
      Pheochromocytoma Benign                          2 (4%)       1 (2%)       4 (8%)                                             
   Islets, Pancreatic                                 (50)         (48)         (49)                                                
      Carcinoma                                        1 (2%)                                                                       
   Parathyroid Gland                                  (49)         (50)         (47)                                                
      Adenoma                                                       1 (2%)                                                          
   Pituitary Gland                                    (50)         (48)         (48)                                                
      Pars Distalis, Adenoma                          23 (46%)     16 (33%)     21 (44%)                                            
      Pars Distalis, Carcinoma                         3 (6%)       9 (19%)      2 (4%)                                             
   Thyroid Gland                                      (50)         (50)         (50)                                                
                                                             Page   2                                                               
NTP Experiment-Test: 05051-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           NITROFURANTOIN                                      Date: 09/07/94  
Route: DOSED FEED                                                                                                 Time: 07:01:33  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   UNTREATD     0.06%        0.13%                                                  
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
      C-Cell, Adenoma                                  3 (6%)       2 (4%)       2 (4%)                                             
      C-Cell, Adenoma, Multiple                                     1 (2%)       2 (4%)                                             
      C-Cell, Carcinoma                                4 (8%)       2 (4%)       2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                                      (3)          (1)                                                 
      Osteosarcoma, Metastatic, Bone                                             1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (44)         (38)         (42)                                                
      Adenoma                                          1 (2%)       7 (18%)      4 (10%)                                            
      Carcinoma                                        4 (9%)       3 (8%)                                                          
   Ovary                                              (50)         (50)         (50)                                                
   Uterus                                             (50)         (50)         (50)                                                
      Leiomyosarcoma                                                             1 (2%)                                             
      Polyp Stromal                                    9 (18%)     16 (32%)     10 (20%)                                            
      Polyp Stromal, Multiple                          1 (2%)                                                                       
      Sarcoma Stromal                                  2 (4%)                                                                       
      Cervix, Sarcoma Stromal                                                    1 (2%)                                             
      Cervix, Squamous Cell Carcinoma                               1 (2%)                                                          
      Endometrium, Adenoma                                                       2 (4%)                                             
      Endometrium, Sarcoma Stromal                                  1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Blood                                              (9)          (2)          (8)                                                 
   Bone Marrow                                        (49)         (48)         (50)                                                
      Sarcoma                                          1 (2%)                                                                       
   Lymph Node                                         (50)         (50)         (50)                                                
   Lymph Node, Mandibular                             (48)         (47)         (50)                                                
   Lymph Node, Mesenteric                             (50)         (48)         (49)                                                
   Spleen                                             (50)         (49)         (50)                                                
      Sarcoma Stromal, Metastatic, Uterus              1 (2%)                                                                       
   Thymus                                             (43)         (34)         (40)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (49)         (50)         (50)                                                
      Adenocarcinoma                                   6 (12%)      4 (8%)                                                          
      Adenocarcinoma, Multiple                                      1 (2%)                                                          
      Fibroadenoma                                    23 (47%)     16 (32%)     16 (32%)                                            
                                                             Page   3                                                               
NTP Experiment-Test: 05051-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           NITROFURANTOIN                                      Date: 09/07/94  
Route: DOSED FEED                                                                                                 Time: 07:01:33  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   UNTREATD     0.06%        0.13%                                                  
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - cont                                                                                                         
      Fibroadenoma, Multiple                           5 (10%)     10 (20%)     15 (30%)                                            
      Fibrosarcoma                                     1 (2%)                                                                       
   Skin                                               (50)         (49)         (50)                                                
      Basal Cell Carcinoma                                                       1 (2%)                                             
      Keratoacanthoma                                                            1 (2%)                                             
      Squamous Cell Papilloma                                                    1 (2%)                                             
      Foot, Squamous Cell Papilloma                                 1 (2%)                                                          
      Subcutaneous Tissue, Fibroma                     1 (2%)       2 (4%)                                                          
      Subcutaneous Tissue, Fibrosarcoma                             1 (2%)                                                          
      Subcutaneous Tissue, Hemangiosarcoma             1 (2%)                                                                       
      Subcutaneous Tissue, Sarcoma                     1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                    (1)                                                                           
      Diaphragm, Sarcoma Stromal, Metastatic,                                                                                       
          Uterus                                       1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)                                                
      Astrocytoma Malignant                                         1 (2%)                                                          
      Carcinoma, Metastatic, Pituitary Gland                        1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)                                                
      Alveolar/Bronchiolar Adenoma                     2 (4%)       2 (4%)       2 (4%)                                             
      Alveolar/Bronchiolar Carcinoma                   1 (2%)                                                                       
      Carcinoma, Metastatic, Thyroid Gland                                       1 (2%)                                             
      Sarcoma Stromal, Metastatic, Uterus              1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Zymbal's Gland                                     (1)          (1)                                                              
      Carcinoma                                        1 (100%)     1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   4                                                               
NTP Experiment-Test: 05051-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           NITROFURANTOIN                                      Date: 09/07/94  
Route: DOSED FEED                                                                                                 Time: 07:01:33  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   UNTREATD     0.06%        0.13%                                                  
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)                                                
      Sarcoma Stromal, Metastatic, Uterus              1 (2%)                                                                       
      Renal Tubule, Adenoma                                                      1 (2%)                                             
   Urinary Bladder                                    (50)         (50)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)                                                
      Leukemia Mononuclear                            13 (26%)     13 (26%)      9 (18%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   5                                                               
NTP Experiment-Test: 05051-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           NITROFURANTOIN                                      Date: 09/07/94  
Route: DOSED FEED                                                                                                 Time: 07:01:33  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   UNTREATD     0.06%        0.13%                                                  
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            49          48          46                                                   
     Total Primary Neoplasms                          109         116         100                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 43          41          42                                                   
     Total Benign Neoplasms                            70          79          82                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              31          28          17                                                   
     Total Malignant Neoplasms                         39          37          18                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              1           1           3                                                   
     Total Metastatic Neoplasm                          7           1           4                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   6                                                               
NTP Experiment-Test: 05051-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           NITROFURANTOIN                                      Date: 09/07/94  
Route: DOSED FEED                                                                                                 Time: 07:01:33  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     UNTREATD     0.13%        0.25%                                                  
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Moribund                                          23           22           21                                                  
    Dead                                               3            1            3                                                  
  Survivors                                                                                                                         
    Moribund                                           1                                                                            
    Terminal Sacrifice                                23           27           26                                                  
  Animals Examined Microscopically                    50           50           50                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (50)         (50)         (48)                                                
      Polyp Adenomatous                                             1 (2%)                                                          
      Muscularis, Leiomyosarcoma                                                 1 (2%)                                             
   Intestine Small, Ileum                             (50)         (49)         (47)                                                
   Intestine Small, Jejunum                           (50)         (50)         (48)                                                
      Cystadenocarcinoma                               1 (2%)                                                                       
   Liver                                              (50)         (50)         (50)                                                
      Fibrosarcoma, Metastatic, Skin                                1 (2%)                                                          
      Hepatocellular Carcinoma                                      1 (2%)                                                          
      Neoplastic Nodule                                1 (2%)       2 (4%)                                                          
      Neoplastic Nodule, Multiple                                   1 (2%)                                                          
   Mesentery                                          (6)          (9)          (6)                                                 
   Pancreas                                           (50)         (50)         (49)                                                
      Acinus, Adenoma                                  2 (4%)                                                                       
   Stomach                                            (49)         (50)         (50)                                                
   Stomach, Forestomach                               (49)         (50)         (49)                                                
      Squamous Cell Papilloma                                                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (50)         (50)                                                
      Adenoma                                                                    1 (2%)                                             
   Adrenal Gland, Medulla                             (50)         (50)         (50)                                                
      Pheochromocytoma Malignant                       3 (6%)       1 (2%)       2 (4%)                                             
      Pheochromocytoma Benign                         18 (36%)     16 (32%)     21 (42%)                                            
      Pheochromocytoma Benign, Multiple                5 (10%)      4 (8%)       2 (4%)                                             
                                                             Page   7                                                               
NTP Experiment-Test: 05051-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           NITROFURANTOIN                                      Date: 09/07/94  
Route: DOSED FEED                                                                                                 Time: 07:01:33  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     UNTREATD     0.13%        0.25%                                                  
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
   Islets, Pancreatic                                 (50)         (50)         (49)                                                
      Adenoma                                          2 (4%)       2 (4%)       1 (2%)                                             
      Carcinoma                                                                  2 (4%)                                             
   Pituitary Gland                                    (50)         (50)         (50)                                                
      Pars Distalis, Adenoma                          10 (20%)     12 (24%)     13 (26%)                                            
      Pars Distalis, Carcinoma                         1 (2%)       2 (4%)       3 (6%)                                             
   Thyroid Gland                                      (50)         (50)         (50)                                                
      C-Cell, Adenoma                                  2 (4%)       7 (14%)      6 (12%)                                            
      C-Cell, Adenoma, Multiple                        1 (2%)                                                                       
      C-Cell, Carcinoma                                             3 (6%)       1 (2%)                                             
      Follicular Cell, Adenoma                                      2 (4%)                                                          
      Follicular Cell, Carcinoma                                    1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (50)         (50)                                                
   Preputial Gland                                    (48)         (50)         (47)                                                
      Adenoma                                          6 (13%)      4 (8%)                                                          
      Adenoma, Multiple                                             1 (2%)                                                          
      Carcinoma                                        6 (13%)      6 (12%)                                                         
   Prostate                                           (50)         (50)         (49)                                                
   Seminal Vesicle                                    (50)         (50)         (50)                                                
   Testes                                             (50)         (50)         (50)                                                
      Interstitial Cell, Adenoma                      13 (26%)      4 (8%)      15 (30%)                                            
      Interstitial Cell, Adenoma, Multiple            34 (68%)     41 (82%)      6 (12%)                                            
      Tunic, Sarcoma                                                             1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Blood                                              (18)         (13)         (10)                                                
   Bone Marrow                                        (50)         (50)         (50)                                                
   Lymph Node                                         (50)         (50)         (50)                                                
      Fibrosarcoma, Metastatic, Skin                                1 (2%)                                                          
      Bronchial, Carcinoma, Metastatic, Zymbal's                                                                                    
          Gland                                                                  1 (2%)                                             
   Lymph Node, Mandibular                             (46)         (50)         (47)                                                
   Lymph Node, Mesenteric                             (49)         (48)         (49)                                                
   Spleen                                             (50)         (50)         (50)                                                
      Hemangiosarcoma                                               1 (2%)                                                          
      Sarcoma                                          1 (2%)                                                                       
                                                             Page   8                                                               
NTP Experiment-Test: 05051-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           NITROFURANTOIN                                      Date: 09/07/94  
Route: DOSED FEED                                                                                                 Time: 07:01:33  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     UNTREATD     0.13%        0.25%                                                  
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
   Thymus                                             (40)         (36)         (34)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (46)         (49)         (46)                                                
      Adenoma                                          1 (2%)                                                                       
      Fibroadenoma                                     2 (4%)       4 (8%)       2 (4%)                                             
   Skin                                               (50)         (50)         (50)                                                
      Basal Cell Carcinoma                             3 (6%)                    3 (6%)                                             
      Carcinoma                                                     1 (2%)                                                          
      Keratoacanthoma                                  4 (8%)       5 (10%)      4 (8%)                                             
      Keratoacanthoma, Multiple                                     1 (2%)                                                          
      Squamous Cell Papilloma                          1 (2%)       1 (2%)       2 (4%)                                             
      Sebaceous Gland, Carcinoma                       1 (2%)                                                                       
      Subcutaneous Tissue, Basosquamous Tumor                                                                                       
          Benign                                                                 1 (2%)                                             
      Subcutaneous Tissue, Fibroma                                  5 (10%)      4 (8%)                                             
      Subcutaneous Tissue, Fibrosarcoma                1 (2%)       1 (2%)       1 (2%)                                             
      Subcutaneous Tissue, Fibrosarcoma, Multiple                   1 (2%)                                                          
      Subcutaneous Tissue, Hemangioma                                            1 (2%)                                             
      Subcutaneous Tissue, Hemangiosarcoma             2 (4%)                                                                       
      Subcutaneous Tissue, Neoplasm NOS                                          1 (2%)                                             
      Subcutaneous Tissue, Schwannoma NOS                           1 (2%)                                                          
      Subcutaneous Tissue, Sebaceous Gland, Adenoma                 1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)                                                
      Fibrosarcoma, Metastatic, Skin                   1 (2%)                                                                       
      Femur, Osteosarcoma                                           1 (2%)       1 (2%)                                             
      Vertebra, Osteosarcoma                                                     1 (2%)                                             
   Skeletal Muscle                                    (1)          (1)                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)                                                
      Astrocytoma Malignant                            1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   9                                                               
NTP Experiment-Test: 05051-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           NITROFURANTOIN                                      Date: 09/07/94  
Route: DOSED FEED                                                                                                 Time: 07:01:33  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     UNTREATD     0.13%        0.25%                                                  
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)                                                
      Carcinoma, Metastatic, Skin                                   1 (2%)                                                          
      Carcinoma, Metastatic, Zymbal's Gland                                      1 (2%)                                             
      Fibrosarcoma, Metastatic, Skin                                1 (2%)                                                          
      Osteosarcoma, Metastatic, Bone                                             1 (2%)                                             
      Bronchus, Squamous Cell Carcinoma                             1 (2%)                                                          
      Pleura, Mediastinum, Alveolar/Bronchiolar                                                                                     
          Carcinoma, Metastatic, Uncertain Primary                                                                                  
          Site                                         1 (2%)                                                                       
   Nose                                               (50)         (49)         (48)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                (16)         (13)         (26)                                                
      Pinna, Schwannoma Malignant                      1 (6%)                                                                       
   Harderian Gland                                    (1)          (5)          (4)                                                 
   Zymbal's Gland                                     (2)                       (1)                                                 
      Carcinoma                                        2 (100%)                  1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)                                                
      Carcinoma, Metastatic, Zymbal's Gland                                      1 (2%)                                             
      Fibrosarcoma, Metastatic, Skin                                1 (2%)                                                          
      Osteosarcoma, Metastatic, Bone                                             1 (2%)                                             
      Pelvis, Transitional Epithelium, Carcinoma                                 1 (2%)                                             
      Renal Tubule, Adenoma                                         1 (2%)       2 (4%)                                             
      Renal Tubule, Carcinoma                                                    1 (2%)                                             
   Urinary Bladder                                    (50)         (50)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)                                                
      Leukemia Mononuclear                            23 (46%)     14 (28%)     15 (30%)                                            
      Mesothelioma Benign                                           1 (2%)       2 (4%)                                             
      Mesothelioma Malignant                           3 (6%)       5 (10%)      1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  10                                                               
NTP Experiment-Test: 05051-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           NITROFURANTOIN                                      Date: 09/07/94  
Route: DOSED FEED                                                                                                 Time: 07:01:33  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     UNTREATD     0.13%        0.25%                                                  
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            49          50          48                                                   
     Total Primary Neoplasms                          151         156         120                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 49          47          40                                                   
     Total Benign Neoplasms                           102         116          84                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              37          31          30                                                   
     Total Malignant Neoplasms                         49          39          35                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              2           2           2                                                   
     Total Metastatic Neoplasm                          2           5           5                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms               1                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                              1           1                                                   
     Total Uncertain Neoplasms                                      1           1                                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.