National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/2649

TR 341 Rat Pathology Tables

NTP Experiment-Test: 05051-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           NITROFURANTOIN                                      Date: 05/06/97
Route: DOSED FEED                                                                                                 Time: 13:25:52




       Facility:  Southern Research Institute

       Chemical CAS #:  67-20-9

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All






































                                                              Page   1

NTP Experiment-Test: 05051-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           NITROFURANTOIN                                      Date: 05/06/97  
Route: DOSED FEED                                                                                                 Time: 13:25:52  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 5| 6| 6| 7| 7| 4| 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 2| 3| 3| 3| 6| 2| 9| 0| 2| 8| 7| 0| 3| 3| 1| 0| 3| 3| 3| 7| 3| 3| 3| 3|             
                                           | 9| 9| 5| 5| 5| 8| 0| 1| 0| 7| 1| 1| 2| 5| 5| 0| 1| 5| 5| 5| 3| 5| 5| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    UNTREATD                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Submucosa, Edema, Diffuse            |                                              4                           |             
      Submucosa, Hemorrhage, Multifocal    |                                              3                           |             
      Submucosa, Inflammation, Diffuse     |                                              3                           |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                            2                    2                 X     2|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis, Focal                   |                                                                         3|             
      Basophilic Focus, Multiple           |                                                    2  2           2      |             
      Clear Cell Focus                     |                                                          3               |             
      Cytologic Alterations, Focal         |                                                                          |             
      Developmental Malformation           |                                                                          |             
      Hyperplasia, Focal                   |                                                                          |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |          3                                                               |             
      Inflammation, Focal, Granulomatous   |                                  2        2                              |             
      Inflammation, Granulomatous,         |                                                                          |             
          Multifocal                       |                                                                3         |             
      Necrosis, Coagulative, Focal         |                   3                                                      |             
      Vacuolization Cytoplasmic, Focal     |                               3                                          |             
      Vacuolization Cytoplasmic, Multifocal|                2                    3                                    |             
      Bile Duct, Hyperplasia               |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                   +        +           +                                 |             
      Fat, Necrosis, Focal                 |                                        3                                 |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy, Focal               |                                                                2        2|             
      Acinus, Atrophy, Multifocal          | 3                                                                        |             
      Duct, Cyst                           | 3                                                                        |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                4                    3                                    |             
      Ulcer, Focal                         |                3                    3                                    |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                               2                                          |             
      Inflammation, Chronic                |                                     4                                    |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05051-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           NITROFURANTOIN                                      Date: 05/06/97  
Route: DOSED FEED                                                                                                 Time: 13:25:52  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 5| 6| 6| 7| 7| 4| 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 2| 3| 3| 3| 6| 2| 9| 0| 2| 8| 7| 0| 3| 3| 1| 0| 3| 3| 3| 7| 3| 3| 3| 3|             
                                           | 9| 9| 5| 5| 5| 8| 0| 1| 0| 7| 1| 1| 2| 5| 5| 0| 1| 5| 5| 5| 3| 5| 5| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    UNTREATD                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis, Multifocal                 |    2     2  2  2  2     3  3     3     3  2  2        2  3     2  3     2|             
      Inflammation, Multifocal             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                   3      |             
      Congestion                           |                                                                          |             
      Cyst                                 |                                                    X                     |             
      Degeneration, Fatty, Focal           |                                                                          |             
      Hyperplasia, Focal                   | 3     2  2                                                               |             
      Vacuolization Cytoplasmic, Diffuse   |                   4                                                      |             
      Vacuolization Cytoplasmic, Focal     |                            2  2                                          |             
      Extra Adrenal Tissue, Accessory      |                                                                          |             
          Adrenal Cortical Nodule          |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Cyst, Multiple                       |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           | 3  3     4     4  2     3        4  4  4              4  3  4     3      |             
      Pars Distalis, Cyst                  |                            X  X              X                           |             
      Pars Distalis, Cyst, Multiple        |       X                 X                 X        X                     |             
      Pars Distalis, Hemorrhage            |                                                                          |             
      Pars Distalis, Hyperplasia, Focal    |                               3                                          |             
      Pars Distalis, Necrosis              |                                              2                           |             
      Pars Distalis, Pigmentation          |                                              2                           |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 |                                                                          |             
      C-Cell, Hyperplasia, Focal           |                                                             2        3   |             
      C-Cell, Hyperplasia, Multifocal      |          2                                                        2      |             
      Follicle, Cyst                       |                                  3                                       |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
      Duct, Cyst                           |    X                                X  X        X              X        X|             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05051-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           NITROFURANTOIN                                      Date: 05/06/97  
Route: DOSED FEED                                                                                                 Time: 13:25:52  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 5| 6| 6| 7| 7| 4| 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 2| 3| 3| 3| 6| 2| 9| 0| 2| 8| 7| 0| 3| 3| 1| 0| 3| 3| 3| 7| 3| 3| 3| 3|             
                                           | 9| 9| 5| 5| 5| 8| 0| 1| 0| 7| 1| 1| 2| 5| 5| 0| 1| 5| 5| 5| 3| 5| 5| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    UNTREATD                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Cyst                                 |          X                                                               |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage, Chronic, Focal           |                                                                          |             
      Cervix, Cyst                         |                                                                      X   |             
      Cervix, Inflammation, Suppurative    |                                                                          |             
      Endometrium, Cyst                    |                                                                          |             
      Endometrium, Hyperplasia, Cystic     |                                                       3                  |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                            +  +     +                                    |             
      Anemia                               |                            X                                             |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Reticulum Cell          |          3                                                               |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inguinal, Hyperplasia, Lymphoid      |                                                                          |             
      Mediastinal, Congestion              |                   4                                                      |             
      Mediastinal, Hyperplasia, Lymphoid   |                      3                                                   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                      3                                                   |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Hyperplasia, Lymphoid                |                      3                                                   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                              3                           |             
      Hematopoietic Cell Proliferation     |                      3                                                   |             
      Pigmentation, Hemosiderin            |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  M  M  +  +  M  +  M  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  |                   3        3  1                                          |             
      Hyperplasia, Lobular                 | 3                       2  3                                            2|             
      Duct, Cyst                           | X  X  X  X           X  X  X     X  X  X  X     X  X  X  X  X  X  X  X  X|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Osteopetrosis                        |                                                                          |             
      Cranium, Hyperostosis                |                                                          2               |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                   +                                                      |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05051-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           NITROFURANTOIN                                      Date: 05/06/97  
Route: DOSED FEED                                                                                                 Time: 13:25:52  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 5| 6| 6| 7| 7| 4| 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 2| 3| 3| 3| 6| 2| 9| 0| 2| 8| 7| 0| 3| 3| 1| 0| 3| 3| 3| 7| 3| 3| 3| 3|             
                                           | 9| 9| 5| 5| 5| 8| 0| 1| 0| 7| 1| 1| 2| 5| 5| 0| 1| 5| 5| 5| 3| 5| 5| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    UNTREATD                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                4                                            3            |             
      Degeneration, Multifocal             |                                  3                                       |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |    +                                                                     |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Infiltration Cellular, Focal,        |                                                                          |             
          Histiocyte                       |                         2                                                |             
      Inflammation, Chronic                |             2                                               3     2     2|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lumen, Foreign Body                  |       3                                                                  |             
      Lumen, Fungus                        |                                                                      X   |             
      Lumen, Inflammation, Suppurative     |                   3                                                  2   |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                                                          4               |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |       +              +     +        +                       +            |             
      Middle Ear, Inflammation, Suppurative|                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Fibrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                      +                                                   |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization, Multifocal           |                                                                   1      |             
      Nephropathy, Chronic                 | 2  2  3  2  2  3     2     2  1  2  3  4  2     2  2  2  3  2  2  2  3  3|             
      Pelvis, Infiltration Cellular,       |                                                                          |             
          Lymphocyte                       |                                                                          |             
      Renal Tubule, Degeneration           |                                                                          |             
      Renal Tubule, Pigmentation,          |                                                                          |             
          Hemosiderin                      |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05051-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           NITROFURANTOIN                                      Date: 05/06/97  
Route: DOSED FEED                                                                                                 Time: 13:25:52  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 0| 5| 1| 2| 3| 3| 3| 3| 3| 3| 2| 2| 2| 3| 3| 6| 6| 0| 2| 3|            |
                                           | 3| 5| 5| 5| 5| 2| 8| 9| 8| 5| 3| 5| 5| 5| 5| 8| 7| 9| 5| 5| 1| 6| 9| 0| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    UNTREATD                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Submucosa, Edema, Diffuse            |                                                                          |      1  4.0|
      Submucosa, Hemorrhage, Multifocal    |                                                                          |      1  3.0|
      Submucosa, Inflammation, Diffuse     |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |          X                          X                                    |      6  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis, Focal                   |                                                                          |      1  3.0|
      Basophilic Focus, Multiple           | 2        X                             3     1  2  2                    2|     10  2.0|
      Clear Cell Focus                     |                                                                          |      1  3.0|
      Cytologic Alterations, Focal         |                                                                      2   |      1  2.0|
      Developmental Malformation           |                               X                                   X      |      2     |
      Hyperplasia, Focal                   |                         2                                                |      1  2.0|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |    2                                                                     |      2  2.5|
      Inflammation, Focal, Granulomatous   |                                                                          |      2  2.0|
      Inflammation, Granulomatous,         |                                                                          |            |
          Multifocal                       |                                           2                              |      2  2.5|
      Necrosis, Coagulative, Focal         |                                                    3                     |      2  3.0|
      Vacuolization Cytoplasmic, Focal     |                      3                                            2      |      3  2.7|
      Vacuolization Cytoplasmic, Multifocal|                                                                          |      2  2.5|
      Bile Duct, Hyperplasia               |                                  2                                       |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                      +  +     +                          +        +      |   8        |
      Fat, Necrosis, Focal                 |                      3  3     3                          3        2      |      6  2.8|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acinus, Atrophy, Focal               |                   3  2                                                  2|      5  2.2|
      Acinus, Atrophy, Multifocal          |                                                                          |      1  3.0|
      Duct, Cyst                           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |                      4                                                   |      3  3.7|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   6                                                               
NTP Experiment-Test: 05051-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           NITROFURANTOIN                                      Date: 05/06/97  
Route: DOSED FEED                                                                                                 Time: 13:25:52  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 0| 5| 1| 2| 3| 3| 3| 3| 3| 3| 2| 2| 2| 3| 3| 6| 6| 0| 2| 3|            |
                                           | 3| 5| 5| 5| 5| 2| 8| 9| 8| 5| 3| 5| 5| 5| 5| 8| 7| 9| 5| 5| 1| 6| 9| 0| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    UNTREATD                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Ulcer, Focal                         |                      4                                                   |      3  3.3|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Erosion                              |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis, Multifocal                 | 3  3  3  3        2        2  2  3  2  3  3        2  2  3  2  4        2|     33  2.5|
      Inflammation, Multifocal             |             3                                                            |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |             3                 3        3           3     3               |      6  3.0|
      Congestion                           |                         3                                                |      1  3.0|
      Cyst                                 |                                                                          |      1     |
      Degeneration, Fatty, Focal           |    3                             3                                       |      2  3.0|
      Hyperplasia, Focal                   |                                                                          |      3  2.3|
      Vacuolization Cytoplasmic, Diffuse   |                                                                          |      1  4.0|
      Vacuolization Cytoplasmic, Focal     |                      3                                            3      |      4  2.5|
      Extra Adrenal Tissue, Accessory      |                                                                          |            |
          Adrenal Cortical Nodule          |                            X                                             |      1     |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Angiectasis                          |                                                          3               |      1  3.0|
      Cyst, Multiple                       |    4                                                                     |      1  4.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Angiectasis           | 4        3        4     3  4  4        3  2           3     4  3  3  4   |     26  3.4|
      Pars Distalis, Cyst                  |       X     X                    X           X                          X|      8     |
      Pars Distalis, Cyst, Multiple        |    X                                                                     |      5     |
      Pars Distalis, Hemorrhage            |                      4                                                   |      1  4.0|
      Pars Distalis, Hyperplasia, Focal    |                                                                         3|      2  3.0|
      Pars Distalis, Necrosis              |                                                                          |      1  2.0|
      Pars Distalis, Pigmentation          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ultimobranchial Cyst                 |                                  X                                       |      1     |
      C-Cell, Hyperplasia, Focal           |                                     3     2                    2         |      5  2.4|
      C-Cell, Hyperplasia, Multifocal      |                         3                                                |      3  2.3|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   7                                                               
NTP Experiment-Test: 05051-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           NITROFURANTOIN                                      Date: 05/06/97  
Route: DOSED FEED                                                                                                 Time: 13:25:52  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 0| 5| 1| 2| 3| 3| 3| 3| 3| 3| 2| 2| 2| 3| 3| 6| 6| 0| 2| 3|            |
                                           | 3| 5| 5| 5| 5| 2| 8| 9| 8| 5| 3| 5| 5| 5| 5| 8| 7| 9| 5| 5| 1| 6| 9| 0| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    UNTREATD                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Follicle, Cyst                       |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|  44        |
      Inflammation, Suppurative            | 4  3                                                                     |      2  3.5|
      Duct, Cyst                           |    X              X                 X  X           X                    X|     12     |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                         X                                                |      2     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage, Chronic, Focal           |             2                                                            |      1  2.0|
      Cervix, Cyst                         |    X                                                                     |      2     |
      Cervix, Inflammation, Suppurative    |    3                                                                     |      1  3.0|
      Endometrium, Cyst                    |                                              X                           |      1     |
      Endometrium, Hyperplasia, Cystic     |       3              3           2                    3                  |      5  2.8|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                   +  +  +        +                 +           +         |   9        |
      Anemia                               |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I|  49        |
      Hyperplasia, Reticulum Cell          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inguinal, Hyperplasia, Lymphoid      |                                                                   3      |      1  3.0|
      Mediastinal, Congestion              |                                                                          |      1  4.0|
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +|  48        |
      Hyperplasia, Lymphoid                |                                                                   3      |      2  3.0|
      Inflammation, Suppurative            |                                                                   3      |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |          3                                                               |      1  3.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                                                          |      1  3.0|
      Hematopoietic Cell Proliferation     | 3                                                  4                    3|      4  3.3|
      Pigmentation, Hemosiderin            |                                                                      3   |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|  43        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   8                                                               
NTP Experiment-Test: 05051-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           NITROFURANTOIN                                      Date: 05/06/97  
Route: DOSED FEED                                                                                                 Time: 13:25:52  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 0| 5| 1| 2| 3| 3| 3| 3| 3| 3| 2| 2| 2| 3| 3| 6| 6| 0| 2| 3|            |
                                           | 3| 5| 5| 5| 5| 2| 8| 9| 8| 5| 3| 5| 5| 5| 5| 8| 7| 9| 5| 5| 1| 6| 9| 0| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    UNTREATD                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia, Cystic                  |                            4        4                                    |      5  3.0|
      Hyperplasia, Lobular                 |                      3                                                   |      5  2.6|
      Duct, Cyst                           |    X  X  X  X     X     X  X  X  X  X  X  X     X  X        X  X  X  X   |     38     |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst Epithelial Inclusion            |                                                                         X|      1     |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Osteopetrosis                        |                                                                         4|      1  4.0|
      Cranium, Hyperostosis                |                                                 2     2                 X|      4  2.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          |                               4                             X  X     X   |      6  3.7|
      Degeneration, Multifocal             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                                                2         |      1  2.0|
      Infiltration Cellular, Focal,        |                                                                          |            |
          Histiocyte                       |             2                                                            |      2  2.0|
      Inflammation, Chronic                |                                                                          |      4  2.3|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lumen, Foreign Body                  |                                                                          |      1  3.0|
      Lumen, Fungus                        |                                                                   X      |      2     |
      Lumen, Inflammation, Suppurative     | 3                                                                 4      |      4  3.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |    +        +  +                                   +  +              +   |  11        |
      Middle Ear, Inflammation, Suppurative|    4                                                                     |      1  4.0|
                                            __________________________________________________________________________|____________|
   Eye                                     |                +                                                         |   1        |
      Inflammation, Suppurative            |                3                                                         |      1  3.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                               +                                          |   1        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   9                                                               
NTP Experiment-Test: 05051-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           NITROFURANTOIN                                      Date: 05/06/97  
Route: DOSED FEED                                                                                                 Time: 13:25:52  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 0| 5| 1| 2| 3| 3| 3| 3| 3| 3| 2| 2| 2| 3| 3| 6| 6| 0| 2| 3|            |
                                           | 3| 5| 5| 5| 5| 2| 8| 9| 8| 5| 3| 5| 5| 5| 5| 8| 7| 9| 5| 5| 1| 6| 9| 0| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    UNTREATD                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Fibrosis                             |                               3                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization, Multifocal           |                                                                          |      1  1.0|
      Nephropathy, Chronic                 |    3  3  2  2     2  3  2  3  2  3  3  1  3  1  2     3  2  2  4  3  2  3|     44  2.4|
      Pelvis, Infiltration Cellular,       |                                                                          |            |
          Lymphocyte                       |                                           3                              |      1  3.0|
      Renal Tubule, Degeneration           |                               3                                          |      1  3.0|
      Renal Tubule, Pigmentation,          |                                                                          |            |
          Hemosiderin                      |                         4                                                |      1  4.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  10                                                               
NTP Experiment-Test: 05051-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           NITROFURANTOIN                                      Date: 05/06/97  
Route: DOSED FEED                                                                                                 Time: 13:25:52  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 7| 7| 7| 7| 5| 6| 7| 7| 7| 4| 5| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 9| 3| 3| 3| 3| 5| 4| 0| 3| 3| 9| 9| 3| 3| 3| 8| 0| 3| 3| 3| 1| 7| 3| 3| 3|             
                                           | 4| 3| 3| 3| 3| 4| 6| 0| 3| 3| 1| 8| 0| 0| 3| 6| 5| 0| 3| 3| 3| 7| 3| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.13%                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Parasite Metazoan                    |                               2                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus, Multiple           |    2  2                 2                 2                             2|             
      Clear Cell Focus                     |                                                 2                        |             
      Cytologic Alterations, Focal         |                                                       3                  |             
      Developmental Malformation           |                                                                          |             
      Focal Cellular Change                |             X                                                            |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Inflammation, Focal, Granulomatous   |          2  2                                                            |             
      Inflammation, Granulomatous,         |                                                                          |             
          Multifocal                       |                                     2                             2  2   |             
      Necrosis, Coagulative, Focal         |                                                                          |             
      Vacuolization Cytoplasmic, Diffuse   |                4                                               3         |             
      Vacuolization Cytoplasmic, Focal     |                                                                          |             
      Vacuolization Cytoplasmic, Multifocal|                                                                          |             
      Bile Duct, Hyperplasia               |             2  2                                                         |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +        +  +           +        +     +                              |             
      Hemorrhage, Focal                    |                            3                                             |             
      Fat, Fibrosis, Focal                 |                                                                          |             
      Fat, Necrosis, Focal                 |    2        3  4                    3     3                              |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Acinus, Atrophy, Focal               |                3              1                                   3     3|             
      Acinus, Atrophy                      |             2                                                            |             
      Acinus, Hyperplasia, Focal           |                                                                          |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                               +                                          |             
      Hyperplasia                          |                               3                                          |             
      Inflammation, Suppurative            |                               2                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                              4                           |             
      Hyperkeratosis                       |                                                                          |             
      Inflammation, Chronic                |                                              4                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  11                                                               
NTP Experiment-Test: 05051-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           NITROFURANTOIN                                      Date: 05/06/97  
Route: DOSED FEED                                                                                                 Time: 13:25:52  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 7| 7| 7| 7| 5| 6| 7| 7| 7| 4| 5| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 9| 3| 3| 3| 3| 5| 4| 0| 3| 3| 9| 9| 3| 3| 3| 8| 0| 3| 3| 3| 1| 7| 3| 3| 3|             
                                           | 4| 3| 3| 3| 3| 4| 6| 0| 3| 3| 1| 8| 0| 0| 3| 6| 5| 0| 3| 3| 3| 7| 3| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.13%                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Ulcer, Focal                         |                                              3                           |             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dysplasia, Focal                     |                                                             2            |             
      Erosion                              |                               3                             2            |             
      Mineralization                       |                                                    2                     |             
      Necrosis, Focal                      | 2                                                                        |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis, Multifocal                 |    3     3  2           3  2        2  2  3     3        2     3  2  2   |             
      Inflammation, Multifocal             |                                                    2                     |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                       3                  |             
      Degeneration, Fatty, Focal           |                   2                 3        2                 2        2|             
      Hyperplasia, Focal                   |                      2                                2                  |             
      Hypertrophy, Focal                   |                                                                      3   |             
      Vacuolization Cytoplasmic, Focal     |                                                                      3   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                       3                  |             
      Hyperplasia, Focal                   |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Hyperplasia                          |                         3                                                |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |    3     3  2     3  2           3  4     3  4     3  3        3  3  3  3|             
      Pars Distalis, Cyst                  |                   X                                         X            |             
      Pars Distalis, Cyst, Multiple        |                                                          X               |             
      Pars Distalis, Hyperplasia, Focal    |       3                       3                                      3   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia, Focal           |                                                                          |             
      C-Cell, Hyperplasia, Multifocal      |                                                                          |             
      Follicle, Hyperplasia, Cystic        |                                                       2                  |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                 +                        |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  M  +  +  +  M  +|             
      Inflammation, Suppurative            |                                                                          |             
      Duct, Cyst                           |                                           X                    X  X      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  12                                                               
NTP Experiment-Test: 05051-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           NITROFURANTOIN                                      Date: 05/06/97  
Route: DOSED FEED                                                                                                 Time: 13:25:52  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 7| 7| 7| 7| 5| 6| 7| 7| 7| 4| 5| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 9| 3| 3| 3| 3| 5| 4| 0| 3| 3| 9| 9| 3| 3| 3| 8| 0| 3| 3| 3| 1| 7| 3| 3| 3|             
                                           | 4| 3| 3| 3| 3| 4| 6| 0| 3| 3| 1| 8| 0| 0| 3| 6| 5| 0| 3| 3| 3| 7| 3| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.13%                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrometra                           |                         3                                                |             
      Cervix, Abscess                      |                                                                          |             
      Cervix, Cyst                         |                                                                          |             
      Cervix, Inflammation, Suppurative    |                                                                          |             
      Endometrium, Hyperplasia, Cystic     |                      2  2  3                 3                    3      |             
      Endometrium, Inflammation,           |                                                                          |             
          Suppurative                      |                      2                                                   |             
      Muscularis, Cyst                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                +  +  +     +                                +            |             
      Anisocytosis                         |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Reticulum Cell          | 3                                                                        |             
      Myelofibrosis                        |                3                                                         |             
      Myeloid Cell, Hyperplasia            |                               2                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Axillary, Hyperplasia, Lymphoid      |                                                                          |             
      Axillary, Infiltration Cellular,     |                                                                          |             
           Plasma Cell                     |                                                                          |             
      Axillary, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                                                                          |             
      Mediastinal, Erythrophagocytosis     |                               3                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erythrophagocytosis                  |                                                                          |             
      Hyperplasia, Lymphoid                |                                     3                                    |             
      Infiltration Cellular, Plasma Cell   |                            3        3                                    |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +|             
      Erythrophagocytosis                  |                                                                          |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                         3                                                |             
      Hematopoietic Cell Proliferation     |             3                 3              3                           |             
      Hemorrhage                           |             3                                                            |             
      Necrosis, Coagulative                |                                                             3            |             
      Pigmentation, Hemosiderin            |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  M  M  +  +  M  +  M  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  |          4     3     4        2     4     4     4                    3   |             
      Hyperplasia, Lobular                 |                                                    3           3         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  13                                                               
NTP Experiment-Test: 05051-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           NITROFURANTOIN                                      Date: 05/06/97  
Route: DOSED FEED                                                                                                 Time: 13:25:52  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 7| 7| 7| 7| 5| 6| 7| 7| 7| 4| 5| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 9| 3| 3| 3| 3| 5| 4| 0| 3| 3| 9| 9| 3| 3| 3| 8| 0| 3| 3| 3| 1| 7| 3| 3| 3|             
                                           | 4| 3| 3| 3| 3| 4| 6| 0| 3| 3| 1| 8| 0| 0| 3| 6| 5| 0| 3| 3| 3| 7| 3| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.13%                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Duct, Cyst                           |    X        X     X  X  X  X     X  X  X  X  X  X  X  X  X     X  X  X  X|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis, Focal                |                                        3                                 |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cranium, Hyperostosis                |                            2                    X                        |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                              4                           |             
      Degeneration, Multifocal             |                                                 3                        |             
      Hemorrhage, Multifocal               |                                                             3            |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                      2   |             
      Congestion                           |                         2                                         2      |             
      Infiltration Cellular, Focal,        |                                                                          |             
          Histiocyte                       |          2     3                                                         |             
      Inflammation, Chronic                |                                                                          |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                3              1                                          |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Multifocal                      |                                              3                           |             
      Bronchiole, Inflammation, Chronic    |                                                                          |             
          Active                           |                3                                                         |             
      Bronchiole, Inflammation, Suppurative|                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lumen, Foreign Body                  |                                                                2         |             
      Lumen, Fungus                        |                                              X                           |             
      Lumen, Inflammation, Suppurative     |                                              2     3           4         |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                                                                         3|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |             +  +                                                         |             
                                            __________________________________________________________________________|             
   Eye                                     |    +                             +                                   +  +|             
      Cataract                             |    3                                                                     |             
      Synechia                             |                                                                          |             
      Cornea, Edema                        |                                                                      2  2|             
      Retina, Degeneration                 |    4                                                                     |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  14                                                               
NTP Experiment-Test: 05051-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           NITROFURANTOIN                                      Date: 05/06/97  
Route: DOSED FEED                                                                                                 Time: 13:25:52  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 7| 7| 7| 7| 5| 6| 7| 7| 7| 4| 5| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 9| 3| 3| 3| 3| 5| 4| 0| 3| 3| 9| 9| 3| 3| 3| 8| 0| 3| 3| 3| 1| 7| 3| 3| 3|             
                                           | 4| 3| 3| 3| 3| 4| 6| 0| 3| 3| 1| 8| 0| 0| 3| 6| 5| 0| 3| 3| 3| 7| 3| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    0.13%                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy, Chronic                 |    3  2  3  1  2  1  1  4  2  1  2  1  1  2  2  3  2  2  1  1  2  2  2  2|             
      Renal Tubule, Hyperplasia, Focal     |          2                                                               |             
      Renal Tubule, Pigmentation,          |                                                                          |             
          Hemosiderin                      |                3           3                                             |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mucosa, Hyperplasia, Diffuse         | 2                                                                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  15                                                               
NTP Experiment-Test: 05051-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           NITROFURANTOIN                                      Date: 05/06/97  
Route: DOSED FEED                                                                                                 Time: 13:25:52  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 4| 4| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 6| 6| 6| 7| 7|            |
                             DAY ON TEST   | 9| 0| 3| 3| 3| 1| 4| 3| 3| 3| 3| 3| 3| 3| 3| 4| 7| 3| 3| 3| 2| 7| 9| 3| 3|            |
                                           | 3| 0| 3| 3| 3| 2| 8| 3| 3| 3| 3| 3| 3| 3| 3| 8| 8| 3| 3| 3| 4| 5| 9| 3| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    0.13%                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Parasite Metazoan                    |                      X                                                   |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Parasite Metazoan                    |                                     X                                    |      2  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  A  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Parasite Metazoan                    |                                              2                           |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus, Multiple           |             2                    2  2                 2                 2|     10  2.0|
      Clear Cell Focus                     |                                                                          |      1  2.0|
      Cytologic Alterations, Focal         |                                                                          |      1  3.0|
      Developmental Malformation           |                                                                         X|      1     |
      Focal Cellular Change                |                                                                          |      1     |
      Hematopoietic Cell Proliferation     |                                              2                           |      1  2.0|
      Inflammation, Focal, Granulomatous   |                                                                          |      2  2.0|
      Inflammation, Granulomatous,         |                                                                          |            |
          Multifocal                       |          2           2        2                    2                     |      7  2.0|
      Necrosis, Coagulative, Focal         |    3                                         1                           |      2  2.0|
      Vacuolization Cytoplasmic, Diffuse   |                                                                          |      2  3.5|
      Vacuolization Cytoplasmic, Focal     |                   3                                                      |      1  3.0|
      Vacuolization Cytoplasmic, Multifocal|                2                                                         |      1  2.0|
      Bile Duct, Hyperplasia               |                            2                             2               |      4  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                +           +                    +                       +|  10        |
      Hemorrhage, Focal                    |                                                                          |      1  3.0|
      Fat, Fibrosis, Focal                 |                                                                         3|      1  3.0|
      Fat, Necrosis, Focal                 |                3           3                                            3|      8  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Acinus, Atrophy, Focal               |                                     3  2  2                       2      |      8  2.4|
      Acinus, Atrophy                      |                                                                          |      1  2.0|
      Acinus, Hyperplasia, Focal           |                      3                                                   |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                                                          |   1        |
      Hyperplasia                          |                                                                          |      1  3.0|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  16                                                               
NTP Experiment-Test: 05051-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           NITROFURANTOIN                                      Date: 05/06/97  
Route: DOSED FEED                                                                                                 Time: 13:25:52  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 4| 4| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 6| 6| 6| 7| 7|            |
                             DAY ON TEST   | 9| 0| 3| 3| 3| 1| 4| 3| 3| 3| 3| 3| 3| 3| 3| 4| 7| 3| 3| 3| 2| 7| 9| 3| 3|            |
                                           | 3| 0| 3| 3| 3| 2| 8| 3| 3| 3| 3| 3| 3| 3| 3| 8| 8| 3| 3| 3| 4| 5| 9| 3| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    0.13%                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |                   3                                                      |      2  3.5|
      Hyperkeratosis                       |                   3                                                      |      1  3.0|
      Inflammation, Chronic                |                                                                          |      1  4.0|
      Ulcer, Focal                         |                                                                          |      1  3.0|
      Epithelium, Hyperplasia              |                   3                                                      |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Dysplasia, Focal                     |                                                                          |      1  2.0|
      Erosion                              |                                                                          |      2  2.5|
      Mineralization                       |    3                          2                                          |      3  2.3|
      Necrosis, Focal                      |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis, Multifocal                 |    2  3  2              2  2  2        3              3  3  3        2  2|     25  2.4|
      Inflammation, Multifocal             |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                          |      1  3.0|
      Degeneration, Fatty, Focal           |                         4                                               2|      7  2.4|
      Hyperplasia, Focal                   | 2                                2                          2           3|      6  2.2|
      Hypertrophy, Focal                   |                                                                          |      1  3.0|
      Vacuolization Cytoplasmic, Focal     |                2                                                         |      2  2.5|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                          |      1  3.0|
      Hyperplasia, Focal                   |                2                                                         |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Hyperplasia                          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  A  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Pars Distalis, Angiectasis           | 2     2                 3  4  3  4                       4     4  3  3  4|     26  3.1|
      Pars Distalis, Cyst                  |             X        X                                                   |      4     |
      Pars Distalis, Cyst, Multiple        |          X                                X                              |      3     |
      Pars Distalis, Hyperplasia, Focal    |       3                       2                                          |      5  2.8|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Hyperplasia, Focal           |       2                                   2        2              2      |      4  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  17                                                               
NTP Experiment-Test: 05051-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           NITROFURANTOIN                                      Date: 05/06/97  
Route: DOSED FEED                                                                                                 Time: 13:25:52  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 4| 4| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 6| 6| 6| 7| 7|            |
                             DAY ON TEST   | 9| 0| 3| 3| 3| 1| 4| 3| 3| 3| 3| 3| 3| 3| 3| 4| 7| 3| 3| 3| 2| 7| 9| 3| 3|            |
                                           | 3| 0| 3| 3| 3| 2| 8| 3| 3| 3| 3| 3| 3| 3| 3| 8| 8| 3| 3| 3| 4| 5| 9| 3| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    0.13%                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      C-Cell, Hyperplasia, Multifocal      |             2                 2                                          |      2  2.0|
      Follicle, Hyperplasia, Cystic        |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  42        |
      Inflammation, Suppurative            | 2                                                                        |      1  2.0|
      Duct, Cyst                           |    X                                X           X  4                     |      7  4.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hydrometra                           |    3                                                                     |      2  3.0|
      Cervix, Abscess                      |          3                    4                                          |      2  3.5|
      Cervix, Cyst                         |                                                    4                     |      1  4.0|
      Cervix, Inflammation, Suppurative    |                         3        3                 3                     |      3  3.0|
      Endometrium, Hyperplasia, Cystic     |       3     3                    3                             3     2   |     10  2.7|
      Endometrium, Inflammation,           |                                                                          |            |
          Suppurative                      |                                                                          |      1  2.0|
      Muscularis, Cyst                     |                   X                                                      |      1     |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   | +                                            +  +                        |   8        |
      Anisocytosis                         | X                                                                        |      1     |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Reticulum Cell          |                                                                         2|      2  2.5|
      Myelofibrosis                        |                                                                          |      1  3.0|
      Myeloid Cell, Hyperplasia            |                3                             3                    3      |      4  2.8|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Axillary, Hyperplasia, Lymphoid      |                                              3                           |      1  3.0|
      Axillary, Infiltration Cellular,     |                                                                          |            |
           Plasma Cell                     |                                              3                           |      1  3.0|
      Axillary, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                                              3                           |      1  3.0|
      Mediastinal, Erythrophagocytosis     |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Erythrophagocytosis                  |                   2                                                      |      1  2.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
      Infiltration Cellular, Plasma Cell   |                                                                          |      2  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  18                                                               
NTP Experiment-Test: 05051-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           NITROFURANTOIN                                      Date: 05/06/97  
Route: DOSED FEED                                                                                                 Time: 13:25:52  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 4| 4| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 6| 6| 6| 7| 7|            |
                             DAY ON TEST   | 9| 0| 3| 3| 3| 1| 4| 3| 3| 3| 3| 3| 3| 3| 3| 4| 7| 3| 3| 3| 2| 7| 9| 3| 3|            |
                                           | 3| 0| 3| 3| 3| 2| 8| 3| 3| 3| 3| 3| 3| 3| 3| 8| 8| 3| 3| 3| 4| 5| 9| 3| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    0.13%                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Erythrophagocytosis                  |                   3                                                      |      1  3.0|
      Infiltration Cellular, Histiocyte    |                                              3                           |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                                             3            |      2  3.0|
      Hematopoietic Cell Proliferation     |    3           4                             3              3     3      |      8  3.1|
      Hemorrhage                           |                                                                          |      1  3.0|
      Necrosis, Coagulative                |                                                                          |      1  3.0|
      Pigmentation, Hemosiderin            |                   3                                                      |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  M  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +|  40        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Cystic                  |    4                                         3        3                  |     11  3.5|
      Hyperplasia, Lobular                 | 2                                                                        |      3  2.7|
      Duct, Cyst                           |    X  X     X  X     X  X  X  X  X  X  X  X     X  X  X  X     X  X  X  X|     39     |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperkeratosis, Focal                |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cranium, Hyperostosis                |          X                          X                 X                  |      5  2.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          |                                                                          |      1  4.0|
      Degeneration, Multifocal             |                            2                    2                        |      3  2.3|
      Hemorrhage, Multifocal               |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |             2                                                            |      2  2.0|
      Congestion                           |                                                                      2  2|      4  2.0|
      Infiltration Cellular, Focal,        |                                                                          |            |
          Histiocyte                       |                2  1                          1                           |      5  1.8|
      Inflammation, Chronic                |                                              1                           |      1  1.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                                                                          |      2  2.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  19                                                               
NTP Experiment-Test: 05051-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           NITROFURANTOIN                                      Date: 05/06/97  
Route: DOSED FEED                                                                                                 Time: 13:25:52  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 4| 4| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 6| 6| 6| 7| 7|            |
                             DAY ON TEST   | 9| 0| 3| 3| 3| 1| 4| 3| 3| 3| 3| 3| 3| 3| 3| 4| 7| 3| 3| 3| 2| 7| 9| 3| 3|            |
                                           | 3| 0| 3| 3| 3| 2| 8| 3| 3| 3| 3| 3| 3| 3| 3| 8| 8| 3| 3| 3| 4| 5| 9| 3| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    0.13%                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
           Multifocal                      |                                                                          |      1  3.0|
      Bronchiole, Inflammation, Chronic    |                                                                          |            |
          Active                           |                                                                          |      1  3.0|
      Bronchiole, Inflammation, Suppurative|                   1                                                      |      1  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  47        |
      Lumen, Foreign Body                  |                                                                          |      1  2.0|
      Lumen, Fungus                        |                                                                          |      1     |
      Lumen, Inflammation, Suppurative     |                                                                          |      3  3.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |                                     3  4                 3               |      4  3.3|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                      +  +                                      +         |   5        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                          +     +         |   6        |
      Cataract                             |                                                                4         |      2  3.5|
      Synechia                             |                                                                4         |      1  4.0|
      Cornea, Edema                        |                                                                          |      2  2.0|
      Retina, Degeneration                 |                                                          2     4         |      3  3.3|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Nephropathy, Chronic                 | 1  1  3  3  3  2  1  2  2  3  1  3  2  4  2     1  2  3  3  1  3  1  2  2|     48  2.0|
      Renal Tubule, Hyperplasia, Focal     |                                                                          |      1  2.0|
      Renal Tubule, Pigmentation,          |                                                                          |            |
          Hemosiderin                      |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mucosa, Hyperplasia, Diffuse         |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  20                                                               
NTP Experiment-Test: 05051-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           NITROFURANTOIN                                      Date: 05/06/97  
Route: DOSED FEED                                                                                                 Time: 13:25:52  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 7| 7| 7| 4| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 6| 3| 3| 3| 2| 6| 3| 3| 3| 7| 2| 2| 3| 3| 6| 3| 3| 3| 3| 0| 2| 3| 3| 3|             
                                           | 5| 4| 4| 4| 4| 3| 7| 0| 4| 4| 0| 7| 8| 0| 4| 5| 4| 4| 4| 4| 1| 6| 0| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    0.06%                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | M  +  +  +  +  M  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Parasite Metazoan                    |                                        X                                 |             
      Mucosa, Mineralization               |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  M  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus, Multiple           |                      2                                               2   |             
      Developmental Malformation           |       X                    X     X                                       |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                                                                          |             
      Inflammation, Granulomatous,         |                                                                          |             
          Multifocal                       |                                                    3              2      |             
      Necrosis, Coagulative, Diffuse       |                                                                          |             
      Vacuolization Cytoplasmic, Diffuse   | 3              3                             4                           |             
      Vacuolization Cytoplasmic, Focal     |                                                                          |             
      Vacuolization Cytoplasmic, Multifocal|                                                                3         |             
      Bile Duct, Hyperplasia               | 3           2     2              3     2                                 |             
      Centrilobular, Congestion            |                                  2                                       |             
      Kupffer Cell, Pigmentation, Bile     |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |       +                 +  +                    +  +  +  +  +            |             
      Infiltration Cellular, Lymphocyte    |                                                    3                     |             
      Inflammation, Focal, Granulomatous   |                                                          3               |             
      Fat, Necrosis, Focal                 |       3                 3  3                    3     3     4            |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Acinus, Atrophy, Focal               |                                                             3        3   |             
      Acinus, Hyperplasia, Focal           |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Cyst                                 |                                              X                           |             
      Edema                                |                                              4                           |             
      Hyperkeratosis                       |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Mineralization                       |                                                                          |             
      Ulcer, Focal                         |                                              4                           |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  21                                                               
NTP Experiment-Test: 05051-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           NITROFURANTOIN                                      Date: 05/06/97  
Route: DOSED FEED                                                                                                 Time: 13:25:52  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 7| 7| 7| 4| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 6| 3| 3| 3| 2| 6| 3| 3| 3| 7| 2| 2| 3| 3| 6| 3| 3| 3| 3| 0| 2| 3| 3| 3|             
                                           | 5| 4| 4| 4| 4| 3| 7| 0| 4| 4| 0| 7| 8| 0| 4| 5| 4| 4| 4| 4| 1| 6| 0| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    0.06%                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic                |                                              4                           |             
      Mineralization                       |                                                                      2   |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
      Inflammation                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis, Multifocal                 |       2  2        3  3  2  2  3  4  2  2  3  3  2  2  3  3  3  3        3|             
      Inflammation, Multifocal             |                   2                                                      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Angiectasis                          |                            3                       4        4            |             
      Degeneration, Fatty, Focal           |                                           3                              |             
      Hemorrhage, Diffuse                  |                                                                          |             
      Hemorrhage, Focal                    |                                        2                                 |             
      Hyperplasia, Focal                   |                            2        2           2                        |             
      Necrosis                             |                                  3                                       |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Angiectasis                          |                                                                          |             
      Hyperplasia, Focal                   |       2                                                                  |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |       3  4           3     2     3  4     4  3           4           4  3|             
      Pars Distalis, Cyst                  |       X                                            X     X               |             
      Pars Distalis, Cyst, Multiple        |                                                                          |             
      Pars Distalis, Hemorrhage            |                               3                                          |             
      Pars Distalis, Hyperplasia, Focal    |                            3                    2                        |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 |                                                                          |             
      C-Cell, Hyperplasia, Focal           |    3  2                                2  1              3        2  2   |             
      C-Cell, Hyperplasia, Multifocal      |                         2                                                |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |       +                                                                  |             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  A  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  22                                                               
NTP Experiment-Test: 05051-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           NITROFURANTOIN                                      Date: 05/06/97  
Route: DOSED FEED                                                                                                 Time: 13:25:52  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 7| 7| 7| 4| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 6| 3| 3| 3| 2| 6| 3| 3| 3| 7| 2| 2| 3| 3| 6| 3| 3| 3| 3| 0| 2| 3| 3| 3|             
                                           | 5| 4| 4| 4| 4| 3| 7| 0| 4| 4| 0| 7| 8| 0| 4| 5| 4| 4| 4| 4| 1| 6| 0| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    0.06%                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Inflammation, Suppurative            |       3                                            3                     |             
      Duct, Cyst                           |             X        X        X           X                              |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrometra                           |                                                                          |             
      Cervix, Abscess                      |                                        3        3                        |             
      Cervix, Cyst                         |             X                                         X              X   |             
      Cervix, Cyst, Multiple               |                                                                          |             
      Cervix, Inflammation, Suppurative    |                                                       2              3   |             
      Endometrium, Hyperplasia, Cystic     |          4                       2                 3                 2  3|             
      Endometrium, Inflammation,           |                                                                          |             
          Suppurative                      |       2                                                                  |             
      Endometrium, Necrosis, Focal         |                                                                          |             
      Lumen, Inflammation, Suppurative     |                                                                4         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |             +                                                            |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Myelofibrosis                        |             3                                                            |             
      Myeloid Cell, Hyperplasia            |                                                    3              3      |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Axillary, Hyperplasia, Lymphoid      |                                                                          |             
      Iliac, Hyperplasia, Lymphoid         |             3                                                            |             
      Mediastinal, Congestion              |                                                                          |             
      Renal, Sinus, Ectasia                |             3                                                            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                      2   |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Atrophy                              |                                                                          |             
      Congestion                           |                                                       3                  |             
      Fibrosis                             |             3                                                            |             
      Hematopoietic Cell Proliferation     |                2                             3                    3      |             
      Hyperplasia, Focal, Lymphoid         |                                                    2                     |             
      Pigmentation, Hemosiderin            |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  M  +  +  M  M  +  +  M  M  M  M  +  +  +  +  +  M  +  M  +  M  +  +  M|             
      Congestion                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  23                                                               
NTP Experiment-Test: 05051-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           NITROFURANTOIN                                      Date: 05/06/97  
Route: DOSED FEED                                                                                                 Time: 13:25:52  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 7| 7| 7| 4| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 6| 3| 3| 3| 2| 6| 3| 3| 3| 7| 2| 2| 3| 3| 6| 3| 3| 3| 3| 0| 2| 3| 3| 3|             
                                           | 5| 4| 4| 4| 4| 3| 7| 0| 4| 4| 0| 7| 8| 0| 4| 5| 4| 4| 4| 4| 1| 6| 0| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    0.06%                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  |    2  4  3        3           4     3     3                          4  4|             
      Hyperplasia, Lobular                 |    3        2        2                                                   |             
      Duct, Cyst                           |       X  X  X        X  X  X     X  X  X  X  X  X  X  X  X     X  X  X  X|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                          |             
      Hyperkeratosis, Focal                |                      3                 3                                 |             
      Hyperplasia, Focal                   |                                        3                                 |             
      Subcutaneous Tissue, Cyst            |                                                                          |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Suppurative                     |                            4     4                                       |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cranium, Hyperostosis                |       2                                X              2                  |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                                                          |             
      Degeneration, Multifocal             |                                                                          |             
      Hemorrhage, Focal                    |                                                             2            |             
      Hemorrhage, Multifocal               |                                                                          |             
      Hydrocephalus                        |                                              3                           |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                  2                             3         |             
      Edema                                |                                                                          |             
      Infiltration Cellular, Focal,        |                                                                          |             
          Histiocyte                       |    1     1        2                                                      |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                                                          |             
      Interstitium, Edema                  |                2  2                                                      |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lumen, Foreign Body                  |                                                                          |             
      Lumen, Inflammation, Suppurative     |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     | 2                 1                                                      |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  24                                                               
NTP Experiment-Test: 05051-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           NITROFURANTOIN                                      Date: 05/06/97  
Route: DOSED FEED                                                                                                 Time: 13:25:52  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 7| 7| 7| 4| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 6| 3| 3| 3| 2| 6| 3| 3| 3| 7| 2| 2| 3| 3| 6| 3| 3| 3| 3| 0| 2| 3| 3| 3|             
                                           | 5| 4| 4| 4| 4| 3| 7| 0| 4| 4| 0| 7| 8| 0| 4| 5| 4| 4| 4| 4| 1| 6| 0| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    0.06%                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |       +  +  +              +              +        +  +  +           +  +|             
                                            __________________________________________________________________________|             
   Eye                                     |       +  +  +        +  +  +  +  +  +     +  +  +  +  +  +        +  +   |             
      Cataract                             |       4  4           3  3  3  3  3  3     2  3  4  3  2  2        3  3   |             
      Inflammation, Suppurative            |                                                                          |             
      Lens, Mineralization                 |          3                                         3                     |             
      Retina, Degeneration                 |       3  3  3        3  3  3  3  4  3     3  3  3  3  3  3        3  3   |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                            +        +                    +               |             
      Fibrosis                             |                            3        4                    3               |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization, Multifocal           |                                                                          |             
      Nephropathy, Chronic                 |    2  2  3  4  1  2  2  3  2  2  2  2  1  1  3  3     3  3  2  2  2  2  3|             
      Pigmentation, Hemosiderin            |                                        3                                 |             
      Cortex, Fibrosis, Focal              |                   3                                                      |             
      Pelvis, Hydronephrosis               |                                                                          |             
      Renal Tubule, Degeneration           |                      3              3                                    |             
      Renal Tubule, Hyperplasia, Focal     |                                                                          |             
      Renal Tubule, Pigmentation,          |                                                                          |             
          Hemosiderin                      |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  25                                                               
NTP Experiment-Test: 05051-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           NITROFURANTOIN                                      Date: 05/06/97  
Route: DOSED FEED                                                                                                 Time: 13:25:52  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 6| 7| 7| 5| 6| 7| 7| 7| 3| 6| 7| 7| 7| 4| 6| 7| 7| 7| 4| 7| 7| 7| 7|            |
                             DAY ON TEST   | 9| 2| 3| 3| 3| 5| 6| 3| 3| 3| 9| 8| 1| 3| 3| 9| 5| 1| 2| 3| 5| 2| 3| 3| 3|            |
                                           | 8| 1| 3| 0| 4| 4| 5| 0| 0| 4| 0| 7| 5| 4| 4| 1| 3| 4| 8| 4| 6| 0| 4| 4| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    0.06%                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Parasite Metazoan                    |                                     X                                    |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Parasite Metazoan                    |                                     X                    X               |      3     |
      Mucosa, Mineralization               |             3                                                            |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus, Multiple           |       2                             2  2  2     2                    2   |      8  2.0|
      Developmental Malformation           |                         X                                                |      4     |
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |       2                                                                  |      1  2.0|
      Inflammation, Granulomatous,         |                                                                          |            |
          Multifocal                       |                      3                                2           2      |      5  2.4|
      Necrosis, Coagulative, Diffuse       |                4                                                         |      1  4.0|
      Vacuolization Cytoplasmic, Diffuse   | 4                                                  4                     |      5  3.6|
      Vacuolization Cytoplasmic, Focal     |                                  2                                       |      1  2.0|
      Vacuolization Cytoplasmic, Multifocal|                                                       3                  |      2  3.0|
      Bile Duct, Hyperplasia               |                                           2                    2         |      7  2.3|
      Centrilobular, Congestion            |                                                                          |      1  2.0|
      Kupffer Cell, Pigmentation, Bile     |                2                                                         |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                   +      |   9        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  3.0|
      Inflammation, Focal, Granulomatous   |                                                                          |      1  3.0|
      Fat, Necrosis, Focal                 |                                                                   3      |      7  3.1|
                                            __________________________________________________________________________|____________|
   Pancreas                                | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Acinus, Atrophy, Focal               |                                     2           3        4               |      5  3.0|
      Acinus, Hyperplasia, Focal           |             2                                      2                     |      2  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +|  48        |
      Cyst                                 |                                                                          |      1     |
      Edema                                |                      4                             4                     |      3  4.0|
      Hyperkeratosis                       |                                                    3  4                  |      2  3.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  26                                                               
NTP Experiment-Test: 05051-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           NITROFURANTOIN                                      Date: 05/06/97  
Route: DOSED FEED                                                                                                 Time: 13:25:52  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 6| 7| 7| 5| 6| 7| 7| 7| 3| 6| 7| 7| 7| 4| 6| 7| 7| 7| 4| 7| 7| 7| 7|            |
                             DAY ON TEST   | 9| 2| 3| 3| 3| 5| 6| 3| 3| 3| 9| 8| 1| 3| 3| 9| 5| 1| 2| 3| 5| 2| 3| 3| 3|            |
                                           | 8| 1| 3| 0| 4| 4| 5| 0| 0| 4| 0| 7| 5| 4| 4| 1| 3| 4| 8| 4| 6| 0| 4| 4| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    0.06%                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia                          |                                                    3  3                  |      2  3.0|
      Inflammation, Chronic                |                            3                                             |      1  3.0|
      Mineralization                       |                            2                                             |      1  2.0|
      Ulcer, Focal                         |                      4                             4                     |      3  4.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +|  48        |
      Inflammation, Chronic                |                                                                          |      1  4.0|
      Mineralization                       |                                                 2                        |      2  2.0|
      Ulcer                                | 3                                                                        |      1  3.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  | +                                                                        |   1        |
      Inflammation                         | 3                                                                        |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis, Multifocal                 | 2           2        3  2  2     2  2  3  3     3     2  3     2     3  2|     34  2.5|
      Inflammation, Multifocal             |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Angiectasis                          |                               4                       4                  |      5  3.8|
      Degeneration, Fatty, Focal           |                         2                 2        4     2               |      5  2.6|
      Hemorrhage, Diffuse                  |                               4                                          |      1  4.0|
      Hemorrhage, Focal                    |                                                                          |      1  2.0|
      Hyperplasia, Focal                   |                                                                          |      3  2.0|
      Necrosis                             |                3                                                         |      2  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Angiectasis                          |                                                       4                  |      1  4.0|
      Hyperplasia, Focal                   |                                                                3         |      2  2.5|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |       2                                                                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Pars Distalis, Angiectasis           |    3     3  4     4  3  4        3  2              4  3  3        3     2|     24  3.3|
      Pars Distalis, Cyst                  |                X           X        X                    X     X         |      8     |
      Pars Distalis, Cyst, Multiple        |                                        X                                 |      1     |
      Pars Distalis, Hemorrhage            |                                                                          |      1  3.0|
      Pars Distalis, Hyperplasia, Focal    |                2           2        3        2                 2         |      7  2.3|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  27                                                               
NTP Experiment-Test: 05051-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           NITROFURANTOIN                                      Date: 05/06/97  
Route: DOSED FEED                                                                                                 Time: 13:25:52  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 6| 7| 7| 5| 6| 7| 7| 7| 3| 6| 7| 7| 7| 4| 6| 7| 7| 7| 4| 7| 7| 7| 7|            |
                             DAY ON TEST   | 9| 2| 3| 3| 3| 5| 6| 3| 3| 3| 9| 8| 1| 3| 3| 9| 5| 1| 2| 3| 5| 2| 3| 3| 3|            |
                                           | 8| 1| 3| 0| 4| 4| 5| 0| 0| 4| 0| 7| 5| 4| 4| 1| 3| 4| 8| 4| 6| 0| 4| 4| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    0.06%                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Ultimobranchial Cyst                 | X                                   X                 X                  |      3     |
      C-Cell, Hyperplasia, Focal           |                         2                          2                     |      9  2.1|
      C-Cell, Hyperplasia, Multifocal      |          2        2                 3                          2         |      5  2.2|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                     +                       +            |   3        |
      Hemorrhage                           |                                                             3            |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  M  M  M  +  +  M  M  +  M  +  +  +  +  +  +  M  +  +  M  +  +  +  +|  38        |
      Inflammation, Suppurative            |    3                       4              4                              |      5  3.4|
      Duct, Cyst                           |    4              X        X           X  X              X     X  X     X|     13  4.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                       X                  |      1     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hydrometra                           |                                           2  2                           |      2  2.0|
      Cervix, Abscess                      |                      3                          4                        |      4  3.3|
      Cervix, Cyst                         |       X                                X                                 |      5     |
      Cervix, Cyst, Multiple               |                                  X                                       |      1     |
      Cervix, Inflammation, Suppurative    |       2                          2                                       |      4  2.3|
      Endometrium, Hyperplasia, Cystic     |                            3        3     3        2              3      |     10  2.8|
      Endometrium, Inflammation,           |                                                                          |            |
          Suppurative                      |                                  2                                       |      2  2.0|
      Endometrium, Necrosis, Focal         |                                  3                                       |      1  3.0|
      Lumen, Inflammation, Suppurative     |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                +         |   2        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Myelofibrosis                        |                4                                                         |      2  3.5|
      Myeloid Cell, Hyperplasia            |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Axillary, Hyperplasia, Lymphoid      |                                                             3            |      1  3.0|
      Iliac, Hyperplasia, Lymphoid         |                                                                          |      1  3.0|
      Mediastinal, Congestion              |                                                             4            |      1  4.0|
      Renal, Sinus, Ectasia                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Hyperplasia, Lymphoid                |       3                                                                  |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  28                                                               
NTP Experiment-Test: 05051-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           NITROFURANTOIN                                      Date: 05/06/97  
Route: DOSED FEED                                                                                                 Time: 13:25:52  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 6| 7| 7| 5| 6| 7| 7| 7| 3| 6| 7| 7| 7| 4| 6| 7| 7| 7| 4| 7| 7| 7| 7|            |
                             DAY ON TEST   | 9| 2| 3| 3| 3| 5| 6| 3| 3| 3| 9| 8| 1| 3| 3| 9| 5| 1| 2| 3| 5| 2| 3| 3| 3|            |
                                           | 8| 1| 3| 0| 4| 4| 5| 0| 0| 4| 0| 7| 5| 4| 4| 1| 3| 4| 8| 4| 6| 0| 4| 4| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    0.06%                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Angiectasis                          |                                                    3                     |      1  3.0|
      Hyperplasia, Lymphoid                |       3                                                                  |      2  2.5|
      Infiltration Cellular, Histiocyte    |                3                                                         |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atrophy                              |                                                    3                     |      1  3.0|
      Congestion                           |                                           3           3              3   |      4  3.0|
      Fibrosis                             |                                                                          |      1  3.0|
      Hematopoietic Cell Proliferation     |                                  3  3  3                                 |      6  2.8|
      Hyperplasia, Focal, Lymphoid         |                                                                   4      |      2  3.0|
      Pigmentation, Hemosiderin            |             3                                                            |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  M  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +|  34        |
      Congestion                           |                                                             4            |      1  4.0|
      Hyperplasia, Lymphoid                |       3                                                                  |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Cystic                  |             4  2     3  4        3     3  3        3                 3  4|     20  3.3|
      Hyperplasia, Lobular                 |                      3           3                                       |      5  2.6|
      Duct, Cyst                           |    X     X  X     X     X  X     X     X  X     X     X  X     X  X      |     33     |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|  49        |
      Cyst Epithelial Inclusion            |                         X                                                |      1     |
      Hyperkeratosis, Focal                |                                                                          |      2  3.0|
      Hyperplasia, Focal                   |                                                                          |      1  3.0|
      Subcutaneous Tissue, Cyst            | X                                                                        |      1     |
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Suppurative                     |                                                                          |      2  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cranium, Hyperostosis                |                      2                                                   |      4  2.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          |                         3                             3                  |      2  3.0|
      Degeneration, Multifocal             |                2                                                         |      1  2.0|
      Hemorrhage, Focal                    |                                                                          |      1  2.0|
      Hemorrhage, Multifocal               |                               3                                          |      1  3.0|
      Hydrocephalus                        |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                    +                     |   1        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  29                                                               
NTP Experiment-Test: 05051-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           NITROFURANTOIN                                      Date: 05/06/97  
Route: DOSED FEED                                                                                                 Time: 13:25:52  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 6| 7| 7| 5| 6| 7| 7| 7| 3| 6| 7| 7| 7| 4| 6| 7| 7| 7| 4| 7| 7| 7| 7|            |
                             DAY ON TEST   | 9| 2| 3| 3| 3| 5| 6| 3| 3| 3| 9| 8| 1| 3| 3| 9| 5| 1| 2| 3| 5| 2| 3| 3| 3|            |
                                           | 8| 1| 3| 0| 4| 4| 5| 0| 0| 4| 0| 7| 5| 4| 4| 1| 3| 4| 8| 4| 6| 0| 4| 4| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    0.06%                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                   2                    2                                 |      4  2.3|
      Edema                                |                                                             4            |      1  4.0|
      Infiltration Cellular, Focal,        |                                                                          |            |
          Histiocyte                       |                                                                          |      3  1.3|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |       3                                                  2               |      2  2.5|
      Inflammation, Chronic                |                                                    2        4            |      2  3.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                                                                         1|      1  1.0|
      Interstitium, Edema                  |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Lumen, Foreign Body                  |                                                             3            |      1  3.0|
      Lumen, Inflammation, Suppurative     |                                                             3            |      1  3.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     | 3                       3                          2                     |      5  2.2|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |          +  +        +  +                 +           +           +     +|  18        |
                                            __________________________________________________________________________|____________|
   Eye                                     |    +                          +                                          |  19        |
      Cataract                             |                                                                          |     16  3.0|
      Inflammation, Suppurative            |    3                                                                     |      1  3.0|
      Lens, Mineralization                 |                                                                          |      2  3.0|
      Retina, Degeneration                 |                                                                          |     17  3.1|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |       +                    +     +              +  +                 +   |   9        |
      Fibrosis                             |                            3     3              4  3                 4   |      8  3.4|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |       2                                                                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |    +                                                                     |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization, Multifocal           |                            2                                             |      1  2.0|
      Nephropathy, Chronic                 | 1  2     2  2     1  4  2  1     2     2  1        4  2  1     2  2     3|     40  2.2|
      Pigmentation, Hemosiderin            |                                                                          |      1  3.0|
      Cortex, Fibrosis, Focal              |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  30                                                               
NTP Experiment-Test: 05051-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           NITROFURANTOIN                                      Date: 05/06/97  
Route: DOSED FEED                                                                                                 Time: 13:25:52  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 6| 7| 7| 5| 6| 7| 7| 7| 3| 6| 7| 7| 7| 4| 6| 7| 7| 7| 4| 7| 7| 7| 7|            |
                             DAY ON TEST   | 9| 2| 3| 3| 3| 5| 6| 3| 3| 3| 9| 8| 1| 3| 3| 9| 5| 1| 2| 3| 5| 2| 3| 3| 3|            |
                                           | 8| 1| 3| 0| 4| 4| 5| 0| 0| 4| 0| 7| 5| 4| 4| 1| 3| 4| 8| 4| 6| 0| 4| 4| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    0.06%                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Pelvis, Hydronephrosis               |                      2                                                   |      1  2.0|
      Renal Tubule, Degeneration           |                                                                          |      2  3.0|
      Renal Tubule, Hyperplasia, Focal     |                                                       2                  |      1  2.0|
      Renal Tubule, Pigmentation,          |                                                                          |            |
          Hemosiderin                      |                3                    3                                    |      2  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  31                                                               
NTP Experiment-Test: 05051-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           NITROFURANTOIN                                      Date: 05/06/97  
Route: DOSED FEED                                                                                                 Time: 13:25:52  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 5| 6| 7| 7| 7| 5| 5| 5| 6| 7| 7| 7| 7| 7| 7| 4| 5| 7| 7| 7|             
                             DAY ON TEST   | 3| 4| 1| 3| 3| 5| 9| 2| 3| 3| 0| 3| 9| 4| 3| 3| 3| 3| 3| 3| 5| 9| 3| 3| 3|             
                                           | 3| 3| 5| 4| 4| 4| 5| 9| 4| 4| 6| 3| 1| 5| 4| 0| 4| 4| 4| 4| 5| 1| 4| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATD                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                  X                                       |             
      Submucosa, Edema                     |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |          X  X                                               X            |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                   3                                                      |             
      Basophilic Focus                     |                               2                                          |             
      Cytologic Alterations, Focal         |       3                 3                                                |             
      Cytologic Alterations, Multifocal    |                                                       3                  |             
      Degeneration, Cystic, Focal          |       3                                                                  |             
      Hyperplasia, Nodular                 |    3                                                                     |             
      Necrosis, Coagulative, Multifocal    |                      3              3                    3               |             
      Vacuolization Cytoplasmic, Diffuse   |                                        4                                 |             
      Vacuolization Cytoplasmic, Focal     |                                                                          |             
      Vacuolization Cytoplasmic, Multifocal|                                                             2            |             
      Bile Duct, Hyperplasia               |          3        2     3                    3           3  2            |             
      Bile Duct, Hyperplasia, Multifocal   |                                                                          |             
      Centrilobular, Degeneration          |       3                                                                  |             
      Portal, Fibrosis                     |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |             +     +           +                                          |             
      Inflammation, Granulomatous          |                                                                          |             
      Fat, Edema                           |                                                                          |             
      Fat, Necrosis, Focal                 |             3                                                            |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |    3     4     2        4  3                             2               |             
      Adventitia, Edema                    |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +|             
      Edema                                |                                        4                                 |             
      Necrosis                             |                                                                          |             
      Ulcer, Focal                         |                                        3                                 |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +|             
      Mineralization                       |       4                                                                  |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  32                                                               
NTP Experiment-Test: 05051-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           NITROFURANTOIN                                      Date: 05/06/97  
Route: DOSED FEED                                                                                                 Time: 13:25:52  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 5| 6| 7| 7| 7| 5| 5| 5| 6| 7| 7| 7| 7| 7| 7| 4| 5| 7| 7| 7|             
                             DAY ON TEST   | 3| 4| 1| 3| 3| 5| 9| 2| 3| 3| 0| 3| 9| 4| 3| 3| 3| 3| 3| 3| 5| 9| 3| 3| 3|             
                                           | 3| 3| 5| 4| 4| 4| 5| 9| 4| 4| 6| 3| 1| 5| 4| 0| 4| 4| 4| 4| 5| 1| 4| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATD                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis, Multifocal                 | 3  3  3  3  3  2  3  2  3  3           2  2     2  3  2  3  2  2  3  3  3|             
      Atrium, Thrombosis                   |                      X                                                   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Cyst                                 |                                                                          |             
      Hyperplasia, Focal                   |    3              3                                                      |             
      Necrosis, Multifocal                 |                                        4                                 |             
      Vacuolization Cytoplasmic, Focal     |    3        3        4  3                    2                           |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |          3  3     3  3  3                                            3  2|             
      Hyperplasia, Multifocal              |                                                                          |             
      Mineralization                       |                                                          3               |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       3                                                                  |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |       2  3        3        3           4              3                  |             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia, Focal    |                2                 2              3                    2   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia, Focal           |          2                             2                                2|             
      C-Cell, Hyperplasia, Multifocal      |                                                                          |             
      Follicle, Cyst                       |                                                                          |             
      Follicle, Cyst, Multiple             |                                                                          |             
      Follicle, Hyperplasia, Cystic        |                                                    3                     |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Cellular                   | 4  2  3     3  2  4  3  3  4  3        4  3  4  4  4  4  4        4  4  4|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +|             
      Atrophy                              |                                                                3         |             
      Fibrosis                             |                4     3     3           3                                 |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Suppurative            |                               3  3  3                       3            |             
      Duct, Cyst                           |                         X              X  X                              |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  33                                                               
NTP Experiment-Test: 05051-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           NITROFURANTOIN                                      Date: 05/06/97  
Route: DOSED FEED                                                                                                 Time: 13:25:52  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 5| 6| 7| 7| 7| 5| 5| 5| 6| 7| 7| 7| 7| 7| 7| 4| 5| 7| 7| 7|             
                             DAY ON TEST   | 3| 4| 1| 3| 3| 5| 9| 2| 3| 3| 0| 3| 9| 4| 3| 3| 3| 3| 3| 3| 5| 9| 3| 3| 3|             
                                           | 3| 3| 5| 4| 4| 4| 5| 9| 4| 4| 6| 3| 1| 5| 4| 0| 4| 4| 4| 4| 5| 1| 4| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATD                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic, Focal         |                                                 2                        |             
      Inflammation, Chronic                |                                                             2            |             
      Inflammation, Suppurative            |    2  4  2        3              3     3  1        2  3        3  1  3  3|             
      Mineralization, Focal                |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Aspermatogenesis                     | 2     2     2  2  2  2  2  2  2        2  2     2  2  2  2        2  2  2|             
      Atrophy                              | 3  3  3  3  3  4  4  3  3  3  4     3  3  4  4  3  3  4  3           4  3|             
      Hemorrhage                           |                                                 3                        |             
      Mineralization                       |                                                       3                  |             
      Arteriole, Necrosis, Fibrinoid       |                                                                         2|             
      Interstitial Cell, Hyperplasia       |                                                                3         |             
      Perivascular, Infiltration Cellular, |                                                                          |             
           Mononuclear Cell                |                                                    2                    2|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |       +  +     +  +     +              M     +           +     +         |             
      Hypochromasia                        |       X                                                                  |             
      Polychromasia                        |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Reticulum Cell          |                3                                                         |             
      Myelofibrosis                        |                                                                         3|             
      Myeloid Cell, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inguinal, Hyperplasia, Lymphoid      |                                                                          |             
      Mediastinal, Congestion              |                                                                          |             
      Mediastinal, Pigmentation,           |                                                                          |             
          Hemosiderin                      |                               4                                          |             
      Pancreatic, Hyperplasia, Lymphoid    |                         3                                                |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +|             
      Cyst                                 |          X                                                               |             
      Hyperplasia, Lymphoid                |          3                 3                                             |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis, Focal                      |                                                                          |             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     |                      2        3                                          |             
      Necrosis                             |                4                                                         |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  M  M  +  +  +  +  M  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  34                                                               
NTP Experiment-Test: 05051-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           NITROFURANTOIN                                      Date: 05/06/97  
Route: DOSED FEED                                                                                                 Time: 13:25:52  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 5| 6| 7| 7| 7| 5| 5| 5| 6| 7| 7| 7| 7| 7| 7| 4| 5| 7| 7| 7|             
                             DAY ON TEST   | 3| 4| 1| 3| 3| 5| 9| 2| 3| 3| 0| 3| 9| 4| 3| 3| 3| 3| 3| 3| 5| 9| 3| 3| 3|             
                                           | 3| 3| 5| 4| 4| 4| 5| 9| 4| 4| 6| 3| 1| 5| 4| 0| 4| 4| 4| 4| 5| 1| 4| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATD                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Duct, Cyst                           |       X  X                                                              X|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alopecia                             |                            X                 X                           |             
      Cyst Epithelial Inclusion            |                                                                          |             
      Hyperkeratosis, Focal                |                                                                          |             
      Prepuce, Ulcer                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                               +                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                                                          |             
      Cerebellum, Hemorrhage, Focal        |                                        3                                 |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atelectasis                          |                      3                                                   |             
      Congestion                           |                                                       3                  |             
      Hemorrhage, Multifocal               |                2                                                         |             
      Infiltration Cellular, Histiocyte    |                2                                                         |             
      Arteriole, Hypertrophy               |                      3                                                   |             
      Interstitium, Infiltration Cellular, |                                                                          |             
           Diffuse, Histiocyte             |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lumen, Fungus                        |       X        2                                                         |             
      Lumen, Inflammation, Suppurative     |          3     2                                                         |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |    +                                +     +  +        +  +     +     +  +|             
                                            __________________________________________________________________________|             
   Eye                                     | +                                            +                       +  +|             
      Cataract                             |                                                                      2   |             
      Retina, Degeneration                 |                                                                      3  2|             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                        +                                 |             
      Fibrosis                             |                                        4                                 |             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          |                +                                                         |             
      Atrophy                              |                2                                                         |             
      Inflammation, Chronic                |                3                                                         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  35                                                               
NTP Experiment-Test: 05051-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           NITROFURANTOIN                                      Date: 05/06/97  
Route: DOSED FEED                                                                                                 Time: 13:25:52  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 5| 6| 7| 7| 7| 5| 5| 5| 6| 7| 7| 7| 7| 7| 7| 4| 5| 7| 7| 7|             
                             DAY ON TEST   | 3| 4| 1| 3| 3| 5| 9| 2| 3| 3| 0| 3| 9| 4| 3| 3| 3| 3| 3| 3| 5| 9| 3| 3| 3|             
                                           | 3| 3| 5| 4| 4| 4| 5| 9| 4| 4| 6| 3| 1| 5| 4| 0| 4| 4| 4| 4| 5| 1| 4| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATD                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                +                                                         |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy, Chronic                 | 3  2  4  3  3  2  3  4  4  4  2  2  3  2  3  2  3  3  4  3  2  3  3  4  3|             
      Cortex, Cyst                         |                                           X                              |             
      Cortex, Necrosis                     |                3                                                         |             
      Renal Tubule, Hyperplasia, Focal     |                         2                                                |             
      Renal Tubule, Pigmentation,          |                                                                          |             
          Hemosiderin                      |                               3                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  36                                                               
NTP Experiment-Test: 05051-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           NITROFURANTOIN                                      Date: 05/06/97  
Route: DOSED FEED                                                                                                 Time: 13:25:52  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 7| 7| 6| 6| 7| 7| 6| 6| 7| 7| 7| 7| 5| 5| 6| 6| 7| 3| 7| 7| 7| 7|            |
                             DAY ON TEST   | 0| 5| 3| 3| 3| 7| 7| 3| 3| 3| 2| 2| 3| 3| 3| 5| 7| 2| 5| 3| 8| 2| 2| 3| 3|            |
                                           | 1| 3| 0| 4| 4| 7| 8| 5| 5| 0| 1| 3| 5| 5| 5| 9| 9| 1| 9| 0| 7| 9| 9| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    UNTREATD                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                                                                          |      1     |
      Submucosa, Edema                     |                                                                   2      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                   X        X        X                                    |      6     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                             2            |      2  2.5|
      Basophilic Focus                     |                                                                          |      1  2.0|
      Cytologic Alterations, Focal         |                   3           2        3                                 |      5  2.8|
      Cytologic Alterations, Multifocal    |                                                                          |      1  3.0|
      Degeneration, Cystic, Focal          |                                           4           2           2      |      4  2.8|
      Hyperplasia, Nodular                 |                                                                          |      1  3.0|
      Necrosis, Coagulative, Multifocal    |                                                                          |      3  3.0|
      Vacuolization Cytoplasmic, Diffuse   |                                                                          |      1  4.0|
      Vacuolization Cytoplasmic, Focal     | 2           3                                      3                     |      3  2.7|
      Vacuolization Cytoplasmic, Multifocal|                                                 2                        |      2  2.0|
      Bile Duct, Hyperplasia               |       3     3     3                                                     3|     10  2.8|
      Bile Duct, Hyperplasia, Multifocal   |                                                       2                  |      1  2.0|
      Centrilobular, Degeneration          |                                                                          |      1  3.0|
      Portal, Fibrosis                     |                                              2                           |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                   +                       +  +                           |   6        |
      Inflammation, Granulomatous          |                                           3                              |      1  3.0|
      Fat, Edema                           |                   3                                                      |      1  3.0|
      Fat, Necrosis, Focal                 |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acinus, Atrophy                      |             3           3                             2                  |      9  2.9|
      Adventitia, Edema                    |                   3                                                      |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Edema                                |                                                    4                     |      2  4.0|
      Necrosis                             |                                                    4                     |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  37                                                               
NTP Experiment-Test: 05051-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           NITROFURANTOIN                                      Date: 05/06/97  
Route: DOSED FEED                                                                                                 Time: 13:25:52  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 7| 7| 6| 6| 7| 7| 6| 6| 7| 7| 7| 7| 5| 5| 6| 6| 7| 3| 7| 7| 7| 7|            |
                             DAY ON TEST   | 0| 5| 3| 3| 3| 7| 7| 3| 3| 3| 2| 2| 3| 3| 3| 5| 7| 2| 5| 3| 8| 2| 2| 3| 3|            |
                                           | 1| 3| 0| 4| 4| 7| 8| 5| 5| 0| 1| 3| 5| 5| 5| 9| 9| 1| 9| 0| 7| 9| 9| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    UNTREATD                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Ulcer, Focal                         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Mineralization                       |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis, Multifocal                 | 3  3  2  3  4  3  3  3  3  3  3     3     3  3  2  3  3  3  2  3  3  3  3|     44  2.8|
      Atrium, Thrombosis                   |             X                                                     X      |      3     |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                         3                                                |      1  3.0|
      Cyst                                 |                X                                                         |      1     |
      Hyperplasia, Focal                   |                                                             2            |      3  2.7|
      Necrosis, Multifocal                 |                                                                          |      1  4.0|
      Vacuolization Cytoplasmic, Focal     |          3  2  3                 3                    2     2            |     11  2.7|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Focal                   |          3                       3                       3               |     10  2.9|
      Hyperplasia, Multifocal              |             3                                                            |      1  3.0|
      Mineralization                       |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |                      2                 3                                 |      3  2.7|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Angiectasis           |                            3           3        4                        |      9  3.1|
      Pars Distalis, Cyst                  |          X                                                               |      1     |
      Pars Distalis, Hyperplasia, Focal    |          2                    2                                      2   |      7  2.1|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Hyperplasia, Focal           |                                  2  3                    2               |      6  2.2|
      C-Cell, Hyperplasia, Multifocal      |                                           3                              |      1  3.0|
      Follicle, Cyst                       |                                                                         X|      1     |
      Follicle, Cyst, Multiple             |                                                       X                  |      1     |
      Follicle, Hyperplasia, Cystic        |                                           3                              |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  38                                                               
NTP Experiment-Test: 05051-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           NITROFURANTOIN                                      Date: 05/06/97  
Route: DOSED FEED                                                                                                 Time: 13:25:52  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 7| 7| 6| 6| 7| 7| 6| 6| 7| 7| 7| 7| 5| 5| 6| 6| 7| 3| 7| 7| 7| 7|            |
                             DAY ON TEST   | 0| 5| 3| 3| 3| 7| 7| 3| 3| 3| 2| 2| 3| 3| 3| 5| 7| 2| 5| 3| 8| 2| 2| 3| 3|            |
                                           | 1| 3| 0| 4| 4| 7| 8| 5| 5| 0| 1| 3| 5| 5| 5| 9| 9| 1| 9| 0| 7| 9| 9| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    UNTREATD                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Coagulating Gland                       |                            +                                             |   1        |
      Inflammation, Chronic                |                            3                                             |      1  3.0|
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Depletion Cellular                   |    4  3  4  3     4  4  4     4  3  4  3  4     3  3  4  4     4  4  3  4|     40  3.6|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Atrophy                              |                                                                          |      1  3.0|
      Fibrosis                             |                                              3                    3  3   |      7  3.1|
      Hyperplasia                          |                         3                                                |      1  3.0|
      Inflammation, Suppurative            | 3     3  3  3        3  3     2                                          |     11  2.9|
      Duct, Cyst                           |             X  X  X           X  X                                      X|      9     |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic, Focal         |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                 2                 2      |      3  2.0|
      Inflammation, Suppurative            | 3        1     3  2  3              1  1     3        4  1  4            |     24  2.5|
      Mineralization, Focal                |                                           2                              |      1  2.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                      3                                                   |      1  3.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Aspermatogenesis                     |    4  2  2  2     2  2  2     4  2  2  2  3     3  3  3  3     3  3  3  3|     38  2.3|
      Atrophy                              | 3  4  4  4  4     4  3  3     4  4  4  4  3     3  4  3  3     4  3     4|     41  3.5|
      Hemorrhage                           |                                                                          |      1  3.0|
      Mineralization                       |                                                                          |      1  3.0|
      Arteriole, Necrosis, Fibrinoid       |                                                                          |      1  2.0|
      Interstitial Cell, Hyperplasia       |                3           2                    2                        |      4  2.5|
      Perivascular, Infiltration Cellular, |                                                                          |            |
           Mononuclear Cell                |                                        2                                 |      3  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |    +  +  +  +  +  +           +  +                    +        +         |  18        |
      Hypochromasia                        |                                                                          |      1     |
      Polychromasia                        |                                                                X         |      1     |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Reticulum Cell          |                                              3                           |      2  3.0|
      Myelofibrosis                        |                                                                          |      1  3.0|
      Myeloid Cell, Hyperplasia            |                                                             2            |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inguinal, Hyperplasia, Lymphoid      |                      4                                                   |      1  4.0|
      Mediastinal, Congestion              |                                              4                           |      1  4.0|
      Mediastinal, Pigmentation,           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  39                                                               
NTP Experiment-Test: 05051-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           NITROFURANTOIN                                      Date: 05/06/97  
Route: DOSED FEED                                                                                                 Time: 13:25:52  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 7| 7| 6| 6| 7| 7| 6| 6| 7| 7| 7| 7| 5| 5| 6| 6| 7| 3| 7| 7| 7| 7|            |
                             DAY ON TEST   | 0| 5| 3| 3| 3| 7| 7| 3| 3| 3| 2| 2| 3| 3| 3| 5| 7| 2| 5| 3| 8| 2| 2| 3| 3|            |
                                           | 1| 3| 0| 4| 4| 7| 8| 5| 5| 0| 1| 3| 5| 5| 5| 9| 9| 1| 9| 0| 7| 9| 9| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    UNTREATD                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
          Hemosiderin                      |                                                                          |      1  4.0|
      Pancreatic, Hyperplasia, Lymphoid    |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +|  46        |
      Cyst                                 |                                                                          |      1     |
      Hyperplasia, Lymphoid                |          3                             3                                 |      4  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  49        |
      Angiectasis                          |             3                                4                    3      |      3  3.3|
      Inflammation, Chronic                |                                              3                           |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis, Focal                      |                3                                                         |      1  3.0|
      Fibrosis                             |                                        3                                 |      1  3.0|
      Hematopoietic Cell Proliferation     |                                              2                           |      3  2.3|
      Necrosis                             |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  M  +  +  M  M  +  +  +  +  +|  40        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +|  46        |
      Duct, Cyst                           |                      X     X              X                              |      6     |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Alopecia                             |                                                                          |      2     |
      Cyst Epithelial Inclusion            |                                  X  X                                    |      2     |
      Hyperkeratosis, Focal                |    3  2                                                                  |      2  2.5|
      Prepuce, Ulcer                       |                            4                                             |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          |                                                 3                        |      1  3.0|
      Cerebellum, Hemorrhage, Focal        |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atelectasis                          |                                                                          |      1  3.0|
      Congestion                           |                                                 2                        |      2  2.5|
      Hemorrhage, Multifocal               |                                                                          |      1  2.0|
      Infiltration Cellular, Histiocyte    |                                              1           3               |      3  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  40                                                               
NTP Experiment-Test: 05051-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           NITROFURANTOIN                                      Date: 05/06/97  
Route: DOSED FEED                                                                                                 Time: 13:25:52  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 7| 7| 6| 6| 7| 7| 6| 6| 7| 7| 7| 7| 5| 5| 6| 6| 7| 3| 7| 7| 7| 7|            |
                             DAY ON TEST   | 0| 5| 3| 3| 3| 7| 7| 3| 3| 3| 2| 2| 3| 3| 3| 5| 7| 2| 5| 3| 8| 2| 2| 3| 3|            |
                                           | 1| 3| 0| 4| 4| 7| 8| 5| 5| 0| 1| 3| 5| 5| 5| 9| 9| 1| 9| 0| 7| 9| 9| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    UNTREATD                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Arteriole, Hypertrophy               |                                                                          |      1  3.0|
      Interstitium, Infiltration Cellular, |                                                                          |            |
           Diffuse, Histiocyte             |                                                                   2      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lumen, Fungus                        |                                                                          |      2  2.0|
      Lumen, Inflammation, Suppurative     |                                                                3         |      3  2.7|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |                                                    2                     |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |       +                                +  +        +  +  +     +         |  16        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   4        |
      Cataract                             |                                                                          |      1  2.0|
      Retina, Degeneration                 |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
      Fibrosis                             |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lacrimal Gland                          |                                                                          |   1        |
      Atrophy                              |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                       +                  |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Nephropathy, Chronic                 | 2  2  4  4  3  4  3  4  4  2  3  4  4  4  4  1  3  2  3  3  2  4  4  3  3|     50  3.1|
      Cortex, Cyst                         |                                     X                                    |      2     |
      Cortex, Necrosis                     |                                                                          |      1  3.0|
      Renal Tubule, Hyperplasia, Focal     |       2                                                                  |      2  2.0|
      Renal Tubule, Pigmentation,          |                                                                          |            |
          Hemosiderin                      |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  41                                                               
NTP Experiment-Test: 05051-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           NITROFURANTOIN                                      Date: 05/06/97  
Route: DOSED FEED                                                                                                 Time: 13:25:52  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 6| 7| 7| 7| 6| 6| 6| 7| 7|             
                             DAY ON TEST   | 8| 5| 0| 1| 2| 3| 3| 3| 3| 3| 1| 1| 3| 3| 3| 9| 4| 3| 3| 3| 3| 9| 9| 3| 3|             
                                           | 7| 9| 5| 6| 8| 3| 0| 0| 0| 0| 9| 9| 0| 0| 0| 3| 6| 0| 0| 0| 9| 7| 9| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.25%                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Parasite Metazoan                    |                      X                    X                              |             
      Submucosa, Edema                     |          4                                            3                  |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | M  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                   3                                                      |             
      Basophilic Focus                     |                                                                         X|             
      Cytologic Alterations, Focal         |                                                                   3     2|             
      Cytologic Alterations, Multifocal    |                   3                                                      |             
      Degeneration, Cystic, Focal          |                                  3                                       |             
      Developmental Malformation           |                                                                          |             
      Hyperplasia, Nodular                 |                                                                          |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                                                                          |             
      Inflammation, Granulomatous,         |                                                                          |             
          Multifocal                       |             3                                                     3      |             
      Mixed Cell Focus                     |          X                                                               |             
      Necrosis, Coagulative, Multifocal    |    2                          3                                          |             
      Vacuolization Cytoplasmic, Diffuse   | 3                                                                        |             
      Vacuolization Cytoplasmic, Focal     |                                              2                           |             
      Bile Duct, Hyperplasia               |    3  3  3                 2     3  2        2           3  3            |             
      Serosa, Fibrosis, Focal              |                                        3                                 |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                        +                 +               |             
      Fibrosis, Focal                      |                                        4                                 |             
      Pigmentation, Hematoidin, Hemosiderin|                                        3                                 |             
      Artery, Inflammation, Chronic        |                                                                          |             
      Artery, Mineralization               |                                                          3               |             
      Artery, Thrombosis                   |                                                          X               |             
      Fat, Necrosis, Focal                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                                   3      |             
      Pigmentation, Hematoidin, Hemosiderin|                                        3                                 |             
      Acinus, Atrophy                      |                   2  2  1        3     4           3                     |             
      Adventitia, Edema                    |          3                                                               |             
      Artery, Inflammation, Chronic        |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  42                                                               
NTP Experiment-Test: 05051-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           NITROFURANTOIN                                      Date: 05/06/97  
Route: DOSED FEED                                                                                                 Time: 13:25:52  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 6| 7| 7| 7| 6| 6| 6| 7| 7|             
                             DAY ON TEST   | 8| 5| 0| 1| 2| 3| 3| 3| 3| 3| 1| 1| 3| 3| 3| 9| 4| 3| 3| 3| 3| 9| 9| 3| 3|             
                                           | 7| 9| 5| 6| 8| 3| 0| 0| 0| 0| 9| 9| 0| 0| 0| 3| 6| 0| 0| 0| 9| 7| 9| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.25%                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Hyperplasia                          |                                                          3               |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                | 3                                                                        |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Mineralization                       |          2                                                               |             
      Ulcer, Focal                         | 2                                                                        |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                | 3                                                                        |             
      Mineralization                       |          3  3     2                       2        1     3  3     2      |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis, Multifocal                 |    3  3  3  4  3  3  2  3  3        2     2  2     2  3  3  3  3  3  2  3|             
      Inflammation, Suppurative            |                                                                          |             
      Atrium, Thrombosis                   |    X                                                                     |             
      Valve, Bacterium                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                        4                                 |             
      Vacuolization Cytoplasmic, Focal     |       3           3  3     2     2              2     2              2  2|             
      Vacuolization Cytoplasmic, Multifocal|                                                          3        2      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Hyperplasia, Focal                   |          3                                                               |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       3  4  3        4              3     3           4  4        3  3  3|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           | 3     3     3        4     3        3     4     3  3                    2|             
      Pars Distalis, Cyst                  |                         X                             X                  |             
      Pars Distalis, Cyst, Multiple        |                                                                   X  X   |             
      Pars Distalis, Hemorrhage            |                                                             4            |             
      Pars Distalis, Hyperplasia, Focal    |                                                                          |             
      Pars Distalis, Hyperplasia,          |                                                                          |             
          Multifocal                       |                                                                          |             
      Pars Distalis, Necrosis              |                                                             4            |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 |                                                                          |             
      C-Cell, Hyperplasia, Focal           |                                                 2                        |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  43                                                               
NTP Experiment-Test: 05051-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           NITROFURANTOIN                                      Date: 05/06/97  
Route: DOSED FEED                                                                                                 Time: 13:25:52  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 6| 7| 7| 7| 6| 6| 6| 7| 7|             
                             DAY ON TEST   | 8| 5| 0| 1| 2| 3| 3| 3| 3| 3| 1| 1| 3| 3| 3| 9| 4| 3| 3| 3| 3| 9| 9| 3| 3|             
                                           | 7| 9| 5| 6| 8| 3| 0| 0| 0| 0| 9| 9| 0| 0| 0| 3| 6| 0| 0| 0| 9| 7| 9| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.25%                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atypia Cellular                      | X     X     X  X  X  X  X              X  X     X     X  X               |             
      Degeneration                         |                                                                          |             
      Depletion Cellular                   | 4  3  4  3  4  4  4  4  3     4        4  4  4  4  4  4  4  4  4  4  4  4|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |          3                    3                          3  3     3      |             
      Duct, Cyst                           |                                                 X                        |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                      X                                                   |             
      Cyst, Multiple                       |                                                                          |             
      Inflammation, Suppurative            | 3  2  3  3  3  3  4  3  3  2  2  3     3     4  3  1        3     3  3   |             
      Mineralization, Multifocal           |                      3                                                   |             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |       4  4        3              2                 3                     |             
      Dilatation                           |                                                                          |             
      Epithelium, Hyperplasia              |       2     3        3  3                                                |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Aspermatogenesis                     | 3  3  4  4  4  4  4  4  4     4           4  3  3  3  4  4  3  3  4  4   |             
      Atrophy                              | 3  3  4  4  4  4  4  4  3  2  4  3  3  4  4  2  4  4  4  4  4  4  4  4  3|             
      Degeneration                         | 3     4  4  4  4  4  4  3     4           3  3  3     3  4  3  3  3  4   |             
      Arteriole, Necrosis, Fibrinoid       |       3           4  3                    3     2     3  2           3   |             
      Interstitial Cell, Hyperplasia       |             1                                                            |             
      Perivascular, Infiltration Cellular, |                                                                          |             
           Mononuclear Cell                |       3           3  3                    3     2     3  3     3     3   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                  +  +                                    |             
      Polychromasia                        |                                  X                                       |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Myelofibrosis                        |       3                                                                  |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inguinal, Hyperplasia, Lymphoid      |                                                                          |             
      Mediastinal, Angiectasis             |                                                                          |             
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |             
      Pancreatic, Hyperplasia, Lymphoid    |                                                                          |             
      Pancreatic, Inflammation,            |                                                                          |             
          Granulomatous                    |             3                                                            |             
      Pancreatic, Mineralization           |             2                                                            |             
      Renal, Angiectasis                   |                                                       3                  |             
      Renal, Hyperplasia, Lymphoid         |                                                 3                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Angiectasis                          |                               3                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  44                                                               
NTP Experiment-Test: 05051-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           NITROFURANTOIN                                      Date: 05/06/97  
Route: DOSED FEED                                                                                                 Time: 13:25:52  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 6| 7| 7| 7| 6| 6| 6| 7| 7|             
                             DAY ON TEST   | 8| 5| 0| 1| 2| 3| 3| 3| 3| 3| 1| 1| 3| 3| 3| 9| 4| 3| 3| 3| 3| 9| 9| 3| 3|             
                                           | 7| 9| 5| 6| 8| 3| 0| 0| 0| 0| 9| 9| 0| 0| 0| 3| 6| 0| 0| 0| 9| 7| 9| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.25%                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Cyst                                 |                      X                                                   |             
      Hyperplasia, Lymphoid                |       3              3              3           3                        |             
      Infiltration Cellular, Plasma Cell   |             3                                                            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Angiectasis                          |          4                    4                                          |             
      Hyperplasia, Lymphoid                |          3                          3           2                        |             
      Mineralization                       |          2                                                               |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                    2  3                  |             
      Fibrosis, Diffuse                    |                                                                          |             
      Fibrosis, Focal                      |             3                                            4               |             
      Hematopoietic Cell Proliferation     |    4                                                                     |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Pigmentation, Hemosiderin            |                                                          3               |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  M  +  +  M  +  M  M  M  M  +  +  +  M  +  +  +  +  M  +  +|             
      Artery, Inflammation                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  M  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Duct, Cyst                           |                   X  X                                            X      |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis, Focal                      |                                                          3               |             
      Hyperkeratosis, Focal                |                                                          3           3   |             
      Hyperplasia, Focal                   |                                                          3               |             
      Inflammation, Chronic                |                                                                      3   |             
      Ulcer, Focal                         |                                                                          |             
      Subcutaneous Tissue, Necrosis, Focal |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |       X  X                                               4        X      |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                                                          |             
      Cerebellum, Hemorrhage, Acute,       |                                                                          |             
          Multifocal                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atelectasis                          |                   2                                                      |             
      Congestion                           |                                                                      2   |             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                      3                                                   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  45                                                               
NTP Experiment-Test: 05051-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           NITROFURANTOIN                                      Date: 05/06/97  
Route: DOSED FEED                                                                                                 Time: 13:25:52  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 6| 7| 7| 7| 6| 6| 6| 7| 7|             
                             DAY ON TEST   | 8| 5| 0| 1| 2| 3| 3| 3| 3| 3| 1| 1| 3| 3| 3| 9| 4| 3| 3| 3| 3| 9| 9| 3| 3|             
                                           | 7| 9| 5| 6| 8| 3| 0| 0| 0| 0| 9| 9| 0| 0| 0| 3| 6| 0| 0| 0| 9| 7| 9| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.25%                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                        2                                 |             
      Alveolus, Edema                      |                                                                          |             
      Interstitium, Infiltration Cellular, |                                                                          |             
           Mononuclear Cell                |                                                       2                  |             
                                            __________________________________________________________________________|             
   Nose                                    | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lumen, Inflammation, Suppurative     |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |       +  +  +        +  +  +        +  +        +  +  +              +  +|             
                                            __________________________________________________________________________|             
   Eye                                     |          +        +     +  +     +  +  +  +     +  +  +           +  +  +|             
      Cataract                             |          3        3     3  3     3  3  3  3     2  3  3           3  3  3|             
      Anterior Chamber, Hemorrhage         |                                                                   3      |             
      Anterior Chamber, Inflammation,      |                                                                          |             
          Suppurative                      |                                                                          |             
      Cornea, Inflammation, Focal,         |                                                                          |             
          Granulomatous                    |                                                                          |             
      Lens, Mineralization                 |                                                                   3     4|             
      Retina, Degeneration                 |          4        3     3  3     3  3  3  3     3  3  3           4  3  3|             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                  +  +                       +  +         |             
      Atrophy                              |                                  3                                       |             
      Fibrosis                             |                                  3  3                       3  3         |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Embolus Bacterial, Multifocal        |                                                                          |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Mineralization                       |                                                             4     2      |             
      Nephropathy, Chronic                 | 3  3  4  4  4  4  4  4  4  3  4  3  4  4  4  1  4  3  4  4  4  3  4  4  3|             
      Cortex, Cyst                         |          X                                                               |             
      Cortex, Cyst, Multiple               |                                                                          |             
      Medulla, Congestion                  |                                                                          |             
      Pelvis, Hydronephrosis               |                                                                          |             
      Pelvis, Transitional Epithelium,     |                                                                          |             
           Hyperplasia                     |                                                                          |             
      Renal Tubule, Hyperplasia, Focal     |                                                                          |             
                                            __________________________________________________________________________|             
   Ureter                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  46                                                               
NTP Experiment-Test: 05051-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           NITROFURANTOIN                                      Date: 05/06/97  
Route: DOSED FEED                                                                                                 Time: 13:25:52  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 6| 7| 7| 7| 6| 6| 6| 7| 7|             
                             DAY ON TEST   | 8| 5| 0| 1| 2| 3| 3| 3| 3| 3| 1| 1| 3| 3| 3| 9| 4| 3| 3| 3| 3| 9| 9| 3| 3|             
                                           | 7| 9| 5| 6| 8| 3| 0| 0| 0| 0| 9| 9| 0| 0| 0| 3| 6| 0| 0| 0| 9| 7| 9| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.25%                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Dilatation                           |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mucosa, Hyperplasia                  |                                              2                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  47                                                               
NTP Experiment-Test: 05051-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           NITROFURANTOIN                                      Date: 05/06/97  
Route: DOSED FEED                                                                                                 Time: 13:25:52  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 3| 6| 7| 7| 7| 4| 5| 6| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7|            |
                             DAY ON TEST   | 2| 3| 3| 3| 3| 8| 3| 3| 3| 3| 1| 3| 7| 1| 3| 0| 3| 3| 3| 3| 3| 3| 7| 3| 3|            |
                                           | 8| 0| 0| 0| 0| 6| 2| 0| 0| 0| 3| 2| 0| 5| 0| 9| 0| 0| 0| 0| 5| 6| 0| 0| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    0.25%                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Parasite Metazoan                    |                                                                          |      2     |
      Submucosa, Edema                     |                         3                                                |      3  3.3|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Parasite Metazoan                    |    X              X                                                      |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                          |      1  3.0|
      Basophilic Focus                     |                                                                          |      1     |
      Cytologic Alterations, Focal         |                                           2              2               |      4  2.3|
      Cytologic Alterations, Multifocal    |                                                                   2      |      2  2.5|
      Degeneration, Cystic, Focal          |                                              2                           |      2  2.5|
      Developmental Malformation           |                                                          X               |      1     |
      Hyperplasia, Nodular                 |                   3                                                      |      1  3.0|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |       2                                                                  |      1  2.0|
      Inflammation, Granulomatous,         |                                                                          |            |
          Multifocal                       | 3                       3                                                |      4  3.0|
      Mixed Cell Focus                     |                                                                          |      1     |
      Necrosis, Coagulative, Multifocal    |                                              3                           |      3  2.7|
      Vacuolization Cytoplasmic, Diffuse   |                                                                          |      1  3.0|
      Vacuolization Cytoplasmic, Focal     |                                                                          |      1  2.0|
      Bile Duct, Hyperplasia               |          2  3     3     2           3  2  3     3  2  3     2           2|     21  2.6|
      Serosa, Fibrosis, Focal              |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                   +                       +           +           +      |   6        |
      Fibrosis, Focal                      |                                                                          |      1  4.0|
      Pigmentation, Hematoidin, Hemosiderin|                                                                          |      1  3.0|
      Artery, Inflammation, Chronic        |                   4                                                      |      1  4.0|
      Artery, Mineralization               |                                                                          |      1  3.0|
      Artery, Thrombosis                   |                                                                          |      1     |
      Fat, Necrosis, Focal                 |                                           3           3           2      |      3  2.7|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia, Focal                   |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  48                                                               
NTP Experiment-Test: 05051-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           NITROFURANTOIN                                      Date: 05/06/97  
Route: DOSED FEED                                                                                                 Time: 13:25:52  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 3| 6| 7| 7| 7| 4| 5| 6| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7|            |
                             DAY ON TEST   | 2| 3| 3| 3| 3| 8| 3| 3| 3| 3| 1| 3| 7| 1| 3| 0| 3| 3| 3| 3| 3| 3| 7| 3| 3|            |
                                           | 8| 0| 0| 0| 0| 6| 2| 0| 0| 0| 3| 2| 0| 5| 0| 9| 0| 0| 0| 0| 5| 6| 0| 0| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    0.25%                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Pigmentation, Hematoidin, Hemosiderin|                                                                          |      1  3.0|
      Acinus, Atrophy                      | 2  3     3  3  2     2                 2                 2        2      |     15  2.4|
      Adventitia, Edema                    |                                                                          |      1  3.0|
      Artery, Inflammation, Chronic        |                   4                                                      |      1  4.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Edema                                |                                              4                           |      2  3.5|
      Inflammation, Chronic                |    4                                                                     |      1  4.0|
      Inflammation, Suppurative            |                                              3                           |      1  3.0|
      Mineralization                       |    2                                                                    2|      3  2.0|
      Ulcer, Focal                         |                                              4                           |      2  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |                                                                          |      1  3.0|
      Mineralization                       | 3     3              1  3                 1                          3   |     14  2.4|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis, Multifocal                 |    3  3  2  2  2  3  3  3  3        3  3  3  3  3  3  3        3  3  3   |     39  2.8|
      Inflammation, Suppurative            |                                        4                                 |      1  4.0|
      Atrium, Thrombosis                   |                                                 3                        |      2  3.0|
      Valve, Bacterium                     |                                        4                                 |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             |                                                                          |      1  4.0|
      Vacuolization Cytoplasmic, Focal     |       2  3        3                       3                       3     2|     15  2.5|
      Vacuolization Cytoplasmic, Multifocal|                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                   4      |      1  4.0|
      Hyperplasia, Focal                   |    2     3  2                                   2  2                 2   |      7  2.3|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |       3  3  3        2  4  3        3     3  2     3                 3  3|     23  3.1|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Angiectasis           |       3                                      4                    4  3   |     14  3.2|
      Pars Distalis, Cyst                  |                                                                X         |      3     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  49                                                               
NTP Experiment-Test: 05051-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           NITROFURANTOIN                                      Date: 05/06/97  
Route: DOSED FEED                                                                                                 Time: 13:25:52  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 3| 6| 7| 7| 7| 4| 5| 6| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7|            |
                             DAY ON TEST   | 2| 3| 3| 3| 3| 8| 3| 3| 3| 3| 1| 3| 7| 1| 3| 0| 3| 3| 3| 3| 3| 3| 7| 3| 3|            |
                                           | 8| 0| 0| 0| 0| 6| 2| 0| 0| 0| 3| 2| 0| 5| 0| 9| 0| 0| 0| 0| 5| 6| 0| 0| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    0.25%                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Pars Distalis, Cyst, Multiple        |                                                                          |      2     |
      Pars Distalis, Hemorrhage            |                                                                          |      1  4.0|
      Pars Distalis, Hyperplasia, Focal    |    2                    2     3                 1              2         |      5  2.0|
      Pars Distalis, Hyperplasia,          |                                                                          |            |
          Multifocal                       |                                        2                                 |      1  2.0|
      Pars Distalis, Necrosis              |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ultimobranchial Cyst                 |                X                                         X               |      2     |
      C-Cell, Hyperplasia, Focal           |                            2              2     2                 2      |      5  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atypia Cellular                      |                                                                          |     12     |
      Degeneration                         |                                                          4               |      1  4.0|
      Depletion Cellular                   | 4  4  4  4  4  4  4  4  4  4  4  3  4  4  4  4  4  4  4     4  4  4  4  4|     46  3.9|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Fibrosis                             |                                                                          |      5  3.0|
      Duct, Cyst                           |                                              X  X                        |      3     |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|  49        |
      Cyst                                 |                                                                         X|      2     |
      Cyst, Multiple                       |          X                                X           X                  |      3     |
      Inflammation, Suppurative            | 2  3  3  3  3     4  3  3  2  3  3  3     2  2     3     2  2     3  2  3|     39  2.8|
      Mineralization, Multifocal           |                                                                          |      1  3.0|
      Epithelium, Hyperplasia              |                                              3                           |      1  3.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                            2                          2  2               |      8  2.8|
      Dilatation                           |                                                                         3|      1  3.0|
      Epithelium, Hyperplasia              |                                                                          |      4  2.8|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Aspermatogenesis                     | 4  4  4  4  3  3  4  4  4  3  3  3  4  4  4  4  3  4  3     3  3  3  4  4|     44  3.6|
      Atrophy                              | 4  4  4  4  3  3  4  4  4  4  3  3  4  4  4  4  4     3     3  3  4  4  4|     48  3.6|
      Degeneration                         | 3  4  3  3  3  3  3  3  3        3  3  3  3  3  3                 3  3  3|     36  3.3|
      Arteriole, Necrosis, Fibrinoid       |    2  3  2           3                    2  3                       3   |     15  2.7|
      Interstitial Cell, Hyperplasia       |             3                                                            |      2  2.0|
      Perivascular, Infiltration Cellular, |                                                                          |            |
           Mononuclear Cell                |    3  3              3     3  2     3     3  3                       3  3|     19  2.9|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  50                                                               
NTP Experiment-Test: 05051-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           NITROFURANTOIN                                      Date: 05/06/97  
Route: DOSED FEED                                                                                                 Time: 13:25:52  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 3| 6| 7| 7| 7| 4| 5| 6| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7|            |
                             DAY ON TEST   | 2| 3| 3| 3| 3| 8| 3| 3| 3| 3| 1| 3| 7| 1| 3| 0| 3| 3| 3| 3| 3| 3| 7| 3| 3|            |
                                           | 8| 0| 0| 0| 0| 6| 2| 0| 0| 0| 3| 2| 0| 5| 0| 9| 0| 0| 0| 0| 5| 6| 0| 0| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    0.25%                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |          +  +     +           M     +  +  +                    +  +      |  10        |
      Polychromasia                        |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                            4                                             |      1  4.0|
      Myelofibrosis                        |                                        4                                 |      2  3.5|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inguinal, Hyperplasia, Lymphoid      |             2                                                            |      1  2.0|
      Mediastinal, Angiectasis             |       3                 3                                                |      2  3.0|
      Mediastinal, Hyperplasia, Lymphoid   |                                        3        3                        |      2  3.0|
      Pancreatic, Hyperplasia, Lymphoid    |                                           3                              |      1  3.0|
      Pancreatic, Inflammation,            |                                                                          |            |
          Granulomatous                    |                                                                          |      1  3.0|
      Pancreatic, Mineralization           |                                                                          |      1  2.0|
      Renal, Angiectasis                   |                   3     4                    3                           |      4  3.3|
      Renal, Hyperplasia, Lymphoid         |       3                                   3                              |      3  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +|  47        |
      Angiectasis                          |                                                                          |      1  3.0|
      Cyst                                 |                                                                          |      1     |
      Hyperplasia, Lymphoid                |       4  3                             3        3  3  4                  |     10  3.2|
      Infiltration Cellular, Plasma Cell   |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Angiectasis                          |                   3                                                      |      3  3.7|
      Hyperplasia, Lymphoid                |                                           3                              |      4  2.8|
      Mineralization                       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                3                                   3                     |      4  2.8|
      Fibrosis, Diffuse                    |                                        3                                 |      1  3.0|
      Fibrosis, Focal                      |    4  3                 3                                      2         |      6  3.2|
      Hematopoietic Cell Proliferation     |                                              3                           |      2  3.5|
      Hyperplasia, Lymphoid                |       3                 3                                                |      2  3.0|
      Pigmentation, Hemosiderin            |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  M  M  +  +  +  M  M  +  M  M  +  +  +  M  +  +  M  +|  34        |
      Artery, Inflammation                 |                   3                                                      |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Duct, Cyst                           |       X           X                          X                       X   |      7     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  51                                                               
NTP Experiment-Test: 05051-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           NITROFURANTOIN                                      Date: 05/06/97  
Route: DOSED FEED                                                                                                 Time: 13:25:52  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 3| 6| 7| 7| 7| 4| 5| 6| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7|            |
                             DAY ON TEST   | 2| 3| 3| 3| 3| 8| 3| 3| 3| 3| 1| 3| 7| 1| 3| 0| 3| 3| 3| 3| 3| 3| 7| 3| 3|            |
                                           | 8| 0| 0| 0| 0| 6| 2| 0| 0| 0| 3| 2| 0| 5| 0| 9| 0| 0| 0| 0| 5| 6| 0| 0| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    0.25%                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis, Focal                      |                                                                          |      1  3.0|
      Hyperkeratosis, Focal                |                                                                          |      2  3.0|
      Hyperplasia, Focal                   |                                                                   4      |      2  3.5|
      Inflammation, Chronic                |          4                                                               |      2  3.5|
      Ulcer, Focal                         |          4                                                               |      1  4.0|
      Subcutaneous Tissue, Necrosis, Focal |                                                             4            |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrous Osteodystrophy               |                         3                                                |      5  3.5|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          |                                              3                    X      |      2  3.0|
      Cerebellum, Hemorrhage, Acute,       |                                                                          |            |
          Multifocal                       |                               3                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atelectasis                          |                                                 3                        |      2  2.5|
      Congestion                           |       2                                                                 2|      3  2.0|
      Infiltration Cellular, Focal,        |                                                                          |            |
          Lymphocyte                       |                                                                          |      1  3.0|
      Infiltration Cellular, Histiocyte    |                         3                       3                        |      2  3.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           | 2                                            3                           |      3  2.3|
      Alveolus, Edema                      |                                  4                                       |      1  4.0|
      Interstitium, Infiltration Cellular, |                                                                          |            |
           Mononuclear Cell                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Lumen, Inflammation, Suppurative     |                         3                                                |      1  3.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |                                     2                             3      |      2  2.5|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     | +  +  +  +           +  +  +     +  +                 +  +           +  +|  26        |
                                            __________________________________________________________________________|____________|
   Eye                                     |    +  +              +  +                                +        +  +  +|  22        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  52                                                               
NTP Experiment-Test: 05051-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           NITROFURANTOIN                                      Date: 05/06/97  
Route: DOSED FEED                                                                                                 Time: 13:25:52  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 3| 6| 7| 7| 7| 4| 5| 6| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7|            |
                             DAY ON TEST   | 2| 3| 3| 3| 3| 8| 3| 3| 3| 3| 1| 3| 7| 1| 3| 0| 3| 3| 3| 3| 3| 3| 7| 3| 3|            |
                                           | 8| 0| 0| 0| 0| 6| 2| 0| 0| 0| 3| 2| 0| 5| 0| 9| 0| 0| 0| 0| 5| 6| 0| 0| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    0.25%                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Cataract                             |                                                                          |     14  2.9|
      Anterior Chamber, Hemorrhage         |                                                                          |      1  3.0|
      Anterior Chamber, Inflammation,      |                                                                          |            |
          Suppurative                      |                                                                      3   |      1  3.0|
      Cornea, Inflammation, Focal,         |                                                                          |            |
          Granulomatous                    |       3                                                                  |      1  3.0|
      Lens, Mineralization                 |                                                                          |      2  3.5|
      Retina, Degeneration                 |                      1                                   2        2      |     17  2.9|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   4        |
      Atrophy                              |                                                                          |      1  3.0|
      Fibrosis                             |                                                                          |      4  3.0|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                  +                                       |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Embolus Bacterial, Multifocal        |                                        3                                 |      1  3.0|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |       3                                                                  |      1  3.0|
      Inflammation, Suppurative            |                                        3                                 |      1  3.0|
      Mineralization                       | 2                                                                        |      3  2.7|
      Nephropathy, Chronic                 | 4  4  4  3  4  2  3  4  4  4        4  3  4  4  3  4  4  3  1  2  3  4  4|     48  3.5|
      Cortex, Cyst                         | X                                                                        |      2     |
      Cortex, Cyst, Multiple               |                                           X                              |      1     |
      Medulla, Congestion                  |                                                 3                        |      1  3.0|
      Pelvis, Hydronephrosis               |                   3                 3                                    |      2  3.0|
      Pelvis, Transitional Epithelium,     |                                                                          |            |
           Hyperplasia                     |                   3                                      3               |      2  3.0|
      Renal Tubule, Hyperplasia, Focal     |                                                    2                     |      1  2.0|
                                            __________________________________________________________________________|____________|
   Ureter                                  |                   +                                                      |   1        |
      Dilatation                           |                   4                                                      |      1  4.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mucosa, Hyperplasia                  |                   2                                                      |      2  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  53                                                               
NTP Experiment-Test: 05051-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           NITROFURANTOIN                                      Date: 05/06/97  
Route: DOSED FEED                                                                                                 Time: 13:25:52  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 0| 2| 3| 3| 3| 9| 2| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 8| 0| 3| 3| 3|             
                                           | 1| 8| 0| 3| 3| 9| 0| 3| 3| 3| 0| 3| 3| 3| 3| 2| 4| 4| 4| 4| 9| 8| 4| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.13%                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Submucosa, Edema                     |       4                                                                  |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                               X                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                      X                                                   |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |          2                                               3               |             
      Congestion                           |    3                                                                     |             
      Cytologic Alterations, Focal         |                   2        2     3     2                                 |             
      Cytologic Alterations, Multifocal    | 2                                               2                        |             
      Degeneration, Cystic, Focal          |    2                                                                     |             
      Developmental Malformation           |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Inflammation, Granulomatous,         |                                                                          |             
          Multifocal                       |                                        2                                 |             
      Vacuolization Cytoplasmic, Focal     |                                                                          |             
      Bile Duct, Hyperplasia               |          2        3                 2        3           2  2     2      |             
      Portal, Fibrosis                     |                                                             2            |             
                                            __________________________________________________________________________|             
   Mesentery                               | +        +                                         +                    +|             
      Artery, Inflammation, Chronic        |                                                                          |             
      Fat, Necrosis, Focal                 | 3        3                                         3                    2|             
      Vein, Mineralization                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |       3           2     2     2  2           2     2  3                  |             
      Artery, Inflammation, Chronic        |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Mineralization                       |                   4                                                      |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                   4                                         3            |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                   +                                                      |             
      Aorta, Mineralization                |                   4                                                      |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  54                                                               
NTP Experiment-Test: 05051-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           NITROFURANTOIN                                      Date: 05/06/97  
Route: DOSED FEED                                                                                                 Time: 13:25:52  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 0| 2| 3| 3| 3| 9| 2| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 8| 0| 3| 3| 3|             
                                           | 1| 8| 0| 3| 3| 9| 0| 3| 3| 3| 0| 3| 3| 3| 3| 2| 4| 4| 4| 4| 9| 8| 4| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.13%                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Fibrosis, Multifocal                 | 3  3  3  2  2  3  3  3  3  3  3  4  3  3  3  3  3  3  3  3  2  2  3  3  2|             
      Mineralization, Multifocal           |                   3                                                      |             
      Atrium, Thrombosis                   |    4  2                                                                  |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Hyperplasia, Focal                   |                                                                          |             
      Hypertrophy, Focal                   |                   3                                                      |             
      Vacuolization Cytoplasmic, Diffuse   |                                                                          |             
      Vacuolization Cytoplasmic, Focal     | 3     4           3     2                                                |             
      Vacuolization Cytoplasmic, Multifocal|                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                       4                  |             
      Hyperplasia, Focal                   |             1        2     2                                             |             
      Hyperplasia, Multifocal              |    2                                                                     |             
      Mineralization                       |                                                       3                  |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       3           4  3  4                                   3           2|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                3        4  4  4  3              2                        |             
      Pars Distalis, Cyst                  |          X                          X                                    |             
      Pars Distalis, Cyst, Multiple        |                                                                          |             
      Pars Distalis, Hyperplasia, Focal    |          2           2                          2        2               |             
      Pars Nervosa, Infiltration Cellular  |                                                    2                     |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 |                      X                                                   |             
      C-Cell, Hyperplasia, Focal           |          2                                               2               |             
      C-Cell, Hyperplasia, Multifocal      |                                                                          |             
      Follicle, Cyst                       |                               X                                          |             
      Follicle, Hyperplasia, Cystic        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |                                                             +            |             
      Hyperplasia                          |                                                             3            |             
      Inflammation, Suppurative            |                                                             3            |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Cellular                   |    3  4  4  3  3  4  3     4  4  4  4  4  4     4  4  4  3  4  4  4  4  3|             
      Fibrosis                             |                                           3                              |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  55                                                               
NTP Experiment-Test: 05051-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           NITROFURANTOIN                                      Date: 05/06/97  
Route: DOSED FEED                                                                                                 Time: 13:25:52  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 0| 2| 3| 3| 3| 9| 2| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 8| 0| 3| 3| 3|             
                                           | 1| 8| 0| 3| 3| 9| 0| 3| 3| 3| 0| 3| 3| 3| 3| 2| 4| 4| 4| 4| 9| 8| 4| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.13%                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Inflammation, Granulomatous          |                                           3                              |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |    3                                                                     |             
      Hyperplasia                          |                                                                3         |             
      Inflammation, Suppurative            |    2                       3        2                       2     4      |             
      Duct, Cyst                           |                                  X                             X  X      |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                          X               |             
      Fibrosis                             | 3        3                             3                    3            |             
      Inflammation, Chronic                |                                                          1               |             
      Inflammation                         |                                                                      2   |             
      Inflammation, Suppurative            |                3     1  2  4  4  2        3        2  1     3     3      |             
      Epithelium, Hyperplasia              |                                                             3            |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                  3                                       |             
      Fibrosis                             |          3                                                               |             
      Mineralization                       |                   3                                                      |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Aspermatogenesis                     |    2  2  2  2     2        2  2  2  2  2  2     2  2  2  2  2  2  2  2  2|             
      Atrophy                              |    3  4  4  3  2  4  2  3  3     4  4  4  4  2  2  4  3  4  3  4  3  4   |             
      Arteriole, Necrosis, Fibrinoid       | 2              2  2  2     2                                             |             
      Interstitial Cell, Hyperplasia       | 1                                                                        |             
      Perivascular, Infiltration Cellular, |                                                                          |             
           Mononuclear Cell                | 2              2  2  2     2                                2            |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                              M        +  +     +        +|             
      Anemia                               |                                                                          |             
      Polychromasia                        |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myeloid Cell, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inguinal, Hyperplasia, Lymphoid      |          3                                                               |             
      Mediastinal, Congestion              |       3                                                                  |             
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |             
      Pancreatic, Hyperplasia, Lymphoid    |                                                                          |             
      Renal, Hyperplasia, Lymphoid         |                2                                                         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Cyst                                 |                      X                                                   |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Ectasia                              |                         1                                                |             
      Hyperplasia, Lymphoid                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  56                                                               
NTP Experiment-Test: 05051-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           NITROFURANTOIN                                      Date: 05/06/97  
Route: DOSED FEED                                                                                                 Time: 13:25:52  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 0| 2| 3| 3| 3| 9| 2| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 8| 0| 3| 3| 3|             
                                           | 1| 8| 0| 3| 3| 9| 0| 3| 3| 3| 0| 3| 3| 3| 3| 2| 4| 4| 4| 4| 9| 8| 4| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.13%                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Fibrosis, Focal                      |                                                 3                        |             
      Hematopoietic Cell Proliferation     |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  M  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Duct, Cyst                           | X           X  X        X     X  X                    X     X            |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                      X                                                   |             
      Fibrosis, Focal                      |                                                                          |             
      Hyperplasia, Focal                   |                                                                          |             
      Ulcer, Focal                         |                                                                          |             
      Subcutaneous Tissue, Mineralization, |                                                                          |             
           Focal                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                   3                                         3            |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          | 3              3                                                         |             
      Cerebellum, Degeneration             |                                                                          |             
      Cerebellum, Hemorrhage, Focal        |                                                                4         |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |             3                                                            |             
      Hemorrhage, Multifocal               |                                                                          |             
      Infiltration Cellular, Histiocyte    |       2                                         2           1            |             
      Inflammation, Suppurative            |                                                                          |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Multifocal                      |                      4                                                   |             
      Alveolus, Edema                      |                                                                          |             
      Alveolus, Mineralization, Multifocal |                   3                                                      |             
      Bronchiole, Foreign Body             |                                                                          |             
      Interstitium, Edema                  |                                                                          |             
      Mediastinum, Pigmentation,           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  57                                                               
NTP Experiment-Test: 05051-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           NITROFURANTOIN                                      Date: 05/06/97  
Route: DOSED FEED                                                                                                 Time: 13:25:52  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 0| 2| 3| 3| 3| 9| 2| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 8| 0| 3| 3| 3|             
                                           | 1| 8| 0| 3| 3| 9| 0| 3| 3| 3| 0| 3| 3| 3| 3| 2| 4| 4| 4| 4| 9| 8| 4| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.13%                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
          Hemosiderin                      |             2                                                            |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lumen, Foreign Body                  |                                                                         3|             
      Lumen, Inflammation, Suppurative     |                                                                         3|             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |       +  +                    +  +                       +               |             
                                            __________________________________________________________________________|             
   Eye                                     |                   +                                                      |             
      Anterior Chamber, Inflammation,      |                                                                          |             
          Suppurative                      |                   3                                                      |             
      Cornea, Infiltration Cellular,       |                                                                          |             
          Lymphocyte                       |                                                                          |             
      Cornea, Mineralization               |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                 +           +            |             
      Ectasia                              |                                                             2            |             
      Fibrosis                             |                                                 3                        |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                             3            |             
      Inflammation, Suppurative            |                                                             2            |             
      Mineralization                       |                   3           2                                          |             
      Nephropathy, Chronic                 | 4  3  4  3  3  3  4  4  4  3  3  3  3  3  3  4  3  3  3  4  4  3  3  3   |             
      Cortex, Cyst                         |                            X                                             |             
      Cortex, Cyst, Multiple               |       X           X                                                      |             
      Pelvis, Hydronephrosis               |                   3     4                                                |             
      Pelvis, Transitional Epithelium,     |                                                                          |             
           Hyperplasia                     |                               2                             3            |             
      Renal Tubule, Hyperplasia, Focal     |                                                                         2|             
      Renal Tubule, Pigmentation,          |                                                                          |             
          Hemosiderin                      |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mucosa, Hyperplasia                  |                                                             3            |             
      Mucosa, Inflammation, Chronic        |                                                             2            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  58                                                               
NTP Experiment-Test: 05051-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           NITROFURANTOIN                                      Date: 05/06/97  
Route: DOSED FEED                                                                                                 Time: 13:25:52  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 5| 6| 7| 7| 4| 7| 7| 7| 7| 6| 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 6| 7| 7|            |
                             DAY ON TEST   | 2| 6| 7| 3| 2| 8| 0| 1| 3| 3| 3| 8| 2| 2| 3| 4| 2| 3| 3| 3| 4| 5| 7| 3| 3|            |
                                           | 0| 1| 9| 4| 7| 3| 0| 2| 4| 4| 0| 7| 2| 6| 4| 8| 8| 0| 4| 4| 4| 6| 1| 0| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    0.13%                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Submucosa, Edema                     |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                X     X                       X        X                  |      5     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Parasite Metazoan                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                          |      2  2.5|
      Congestion                           |                                                             3            |      2  3.0|
      Cytologic Alterations, Focal         |          2                                                               |      5  2.2|
      Cytologic Alterations, Multifocal    |                                                                          |      2  2.0|
      Degeneration, Cystic, Focal          |                                        2                                 |      2  2.0|
      Developmental Malformation           |                                                                      X   |      1     |
      Hematopoietic Cell Proliferation     |                                     2                                    |      1  2.0|
      Inflammation, Granulomatous,         |                                                                          |            |
          Multifocal                       |                               3  2                                       |      3  2.3|
      Vacuolization Cytoplasmic, Focal     |                                              2                           |      1  2.0|
      Bile Duct, Hyperplasia               |    3     2           3     2           2        2        1              3|     15  2.3|
      Portal, Fibrosis                     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |       +                       +     +                    +        +      |   9        |
      Artery, Inflammation, Chronic        |                                                                   4      |      1  4.0|
      Fat, Necrosis, Focal                 |                                                          3               |      5  2.8|
      Vein, Mineralization                 |                                     3                                    |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acinus, Atrophy                      |                3        2                                                |     10  2.3|
      Artery, Inflammation, Chronic        |                                  4                       3               |      2  3.5|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |                3                 4  3                                    |      3  3.3|
      Mineralization                       |                                  3  3                                    |      3  3.3|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       |                            2     3  3     3                       2  2   |      8  2.8|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  59                                                               
NTP Experiment-Test: 05051-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           NITROFURANTOIN                                      Date: 05/06/97  
Route: DOSED FEED                                                                                                 Time: 13:25:52  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 5| 6| 7| 7| 4| 7| 7| 7| 7| 6| 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 6| 7| 7|            |
                             DAY ON TEST   | 2| 6| 7| 3| 2| 8| 0| 1| 3| 3| 3| 8| 2| 2| 3| 4| 2| 3| 3| 3| 4| 5| 7| 3| 3|            |
                                           | 0| 1| 9| 4| 7| 3| 0| 2| 4| 4| 0| 7| 2| 6| 4| 8| 8| 0| 4| 4| 4| 6| 1| 0| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    0.13%                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
      Aorta, Mineralization                |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis, Multifocal                 |    2  2  2  3  2  3  3  3  3  2  3  2  2        3  2     2  3  2  3  3   |     45  2.7|
      Mineralization, Multifocal           |                                                                          |      1  3.0|
      Atrium, Thrombosis                   |                                                    X                     |      3  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                    4                     |      1  4.0|
      Hyperplasia, Focal                   |                                  2                       2               |      2  2.0|
      Hypertrophy, Focal                   |                               3                                          |      2  3.0|
      Vacuolization Cytoplasmic, Diffuse   |                                              2                           |      1  2.0|
      Vacuolization Cytoplasmic, Focal     |                                                             2  2         |      6  2.7|
      Vacuolization Cytoplasmic, Multifocal|                                        2                                 |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                                          |      1  4.0|
      Hyperplasia, Focal                   |                      3  2        2     3                                3|      8  2.3|
      Hyperplasia, Multifocal              |                                                 3                        |      2  2.5|
      Mineralization                       |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|  47        |
      Hyperplasia                          |       2     3  2           3     4  3  3  2     3           3     4  4   |     18  3.1|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Angiectasis           |                                                             2            |      7  3.1|
      Pars Distalis, Cyst                  |                                                                          |      2     |
      Pars Distalis, Cyst, Multiple        |                                              X                           |      1     |
      Pars Distalis, Hyperplasia, Focal    |                                        2           2                     |      6  2.0|
      Pars Nervosa, Infiltration Cellular  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ultimobranchial Cyst                 |                                                                          |      1     |
      C-Cell, Hyperplasia, Focal           |                                                                          |      2  2.0|
      C-Cell, Hyperplasia, Multifocal      |                                                             4            |      1  4.0|
      Follicle, Cyst                       |                                                                          |      1     |
      Follicle, Hyperplasia, Cystic        |                   2                                                      |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  60                                                               
NTP Experiment-Test: 05051-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           NITROFURANTOIN                                      Date: 05/06/97  
Route: DOSED FEED                                                                                                 Time: 13:25:52  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 5| 6| 7| 7| 4| 7| 7| 7| 7| 6| 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 6| 7| 7|            |
                             DAY ON TEST   | 2| 6| 7| 3| 2| 8| 0| 1| 3| 3| 3| 8| 2| 2| 3| 4| 2| 3| 3| 3| 4| 5| 7| 3| 3|            |
                                           | 0| 1| 9| 4| 7| 3| 0| 2| 4| 4| 0| 7| 2| 6| 4| 8| 8| 0| 4| 4| 4| 6| 1| 0| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    0.13%                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Coagulating Gland                       |                                                                          |   1        |
      Hyperplasia                          |                                                                          |      1  3.0|
      Inflammation, Suppurative            |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Depletion Cellular                   |    3  3  4  4     4  4  4  4  4  4  4     4     4  4  4  4  4  4  4  4  4|     43  3.8|
      Fibrosis                             |                                                                          |      1  3.0|
      Inflammation, Granulomatous          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             |    3                                               3                     |      3  3.0|
      Hyperplasia                          |                                                                          |      1  3.0|
      Inflammation, Suppurative            |                                     4                                    |      6  2.8|
      Duct, Cyst                           | X                 X           X  X  X                 X     X     X  X  X|     13     |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                        X                                 |      2     |
      Fibrosis                             |                                                                          |      4  3.0|
      Inflammation, Chronic                |                                     2                                    |      2  1.5|
      Inflammation                         |                                                                          |      1  2.0|
      Inflammation, Suppurative            |    4                                   2           3     3  3     3  3  3|     19  2.7|
      Epithelium, Hyperplasia              |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                      3                          3  3  4  3        3  3   |      8  3.1|
      Fibrosis                             |                                                                          |      1  3.0|
      Mineralization                       |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Aspermatogenesis                     |       2  2  2     2  2  2  2  4  2  2     2     2  2  2  2  2  2  2  2  2|     40  2.1|
      Atrophy                              |    2  3  3  4     3  3  4  4  3  3  4     4  2  3  4  4  4  4  4  4  4  3|     44  3.4|
      Arteriole, Necrosis, Fibrinoid       |                                  1                          2     2      |      8  1.9|
      Interstitial Cell, Hyperplasia       | 2                                                           3            |      3  2.0|
      Perivascular, Infiltration Cellular, |                                                                          |            |
           Mononuclear Cell                |                                  2                          2     2      |      9  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |       +     +        +     +              +     +        +     +        +|  13        |
      Anemia                               |       X                                                                  |      1     |
      Polychromasia                        |       X                                                                  |      1     |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Myeloid Cell, Hyperplasia            |                3  3                                                      |      2  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inguinal, Hyperplasia, Lymphoid      |                                                                         3|      2  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  61                                                               
NTP Experiment-Test: 05051-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           NITROFURANTOIN                                      Date: 05/06/97  
Route: DOSED FEED                                                                                                 Time: 13:25:52  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 5| 6| 7| 7| 4| 7| 7| 7| 7| 6| 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 6| 7| 7|            |
                             DAY ON TEST   | 2| 6| 7| 3| 2| 8| 0| 1| 3| 3| 3| 8| 2| 2| 3| 4| 2| 3| 3| 3| 4| 5| 7| 3| 3|            |
                                           | 0| 1| 9| 4| 7| 3| 0| 2| 4| 4| 0| 7| 2| 6| 4| 8| 8| 0| 4| 4| 4| 6| 1| 0| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    0.13%                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Mediastinal, Congestion              |                                                                          |      1  3.0|
      Mediastinal, Hyperplasia, Lymphoid   |                                                             3            |      1  3.0|
      Pancreatic, Hyperplasia, Lymphoid    |                                  3                                       |      1  3.0|
      Renal, Hyperplasia, Lymphoid         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                               4                                          |      1  4.0|
      Cyst                                 |                                                                          |      1     |
      Hyperplasia, Lymphoid                |                                                             3           3|      2  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|  48        |
      Ectasia                              |             4                                                            |      2  2.5|
      Hyperplasia, Lymphoid                |       3                       3                                      3   |      3  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                   3                                3  3              2   |      4  2.8|
      Fibrosis, Focal                      |                                                                   4      |      2  3.5|
      Hematopoietic Cell Proliferation     |                               3                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  M  +  +  M  +  M  +  +  +  +  +  M  M  +  +  +  M  +  +  M  +  M  +  +|  36        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  49        |
      Duct, Cyst                           |       X  X                          X                                    |     11     |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst Epithelial Inclusion            |       X              X                                                   |      3     |
      Fibrosis, Focal                      |       3                                         4        3               |      3  3.3|
      Hyperplasia, Focal                   |                                                 4                        |      1  4.0|
      Ulcer, Focal                         |                                              3                           |      1  3.0|
      Subcutaneous Tissue, Mineralization, |                                                                          |            |
           Focal                           |       3                                                                  |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrous Osteodystrophy               |                                  3  2  3                                 |      5  2.8|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                               +                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          |                                                                          |      2  3.0|
      Cerebellum, Degeneration             |                                                                3         |      1  3.0|
      Cerebellum, Hemorrhage, Focal        |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                      +                       +                           |   2        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  62                                                               
NTP Experiment-Test: 05051-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           NITROFURANTOIN                                      Date: 05/06/97  
Route: DOSED FEED                                                                                                 Time: 13:25:52  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 5| 6| 7| 7| 4| 7| 7| 7| 7| 6| 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 6| 7| 7|            |
                             DAY ON TEST   | 2| 6| 7| 3| 2| 8| 0| 1| 3| 3| 3| 8| 2| 2| 3| 4| 2| 3| 3| 3| 4| 5| 7| 3| 3|            |
                                           | 0| 1| 9| 4| 7| 3| 0| 2| 4| 4| 0| 7| 2| 6| 4| 8| 8| 0| 4| 4| 4| 6| 1| 0| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    0.13%                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                                                      3   |      2  3.0|
      Hemorrhage, Multifocal               |                                        3                                 |      1  3.0|
      Infiltration Cellular, Histiocyte    |    1              2                 3  2                             2   |      8  1.9|
      Inflammation, Suppurative            |                2                                                         |      1  2.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                                                             2            |      1  2.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Multifocal                      |                                                                          |      1  4.0|
      Alveolus, Edema                      |                                     3                                    |      1  3.0|
      Alveolus, Mineralization, Multifocal |                                                                          |      1  3.0|
      Bronchiole, Foreign Body             |                2                                                         |      1  2.0|
      Interstitium, Edema                  |                2                                                         |      1  2.0|
      Mediastinum, Pigmentation,           |                                                                          |            |
          Hemosiderin                      |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Lumen, Foreign Body                  |                                                                          |      1  3.0|
      Lumen, Inflammation, Suppurative     |                                                                          |      1  3.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |                2                                            2        2  3|      4  2.3|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |          +           +  +                 +     +     +     +        +   |  13        |
                                            __________________________________________________________________________|____________|
   Eye                                     |          +                       +              +           +           +|   6        |
      Anterior Chamber, Inflammation,      |                                                                          |            |
          Suppurative                      |                                                                          |      1  3.0|
      Cornea, Infiltration Cellular,       |                                                                          |            |
          Lymphocyte                       |                                                             2            |      1  2.0|
      Cornea, Mineralization               |                                  4                                       |      1  4.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                +           +              +                              |   5        |
      Ectasia                              |                3                                                         |      2  2.5|
      Fibrosis                             |                            3              3                              |      3  3.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  63                                                               
NTP Experiment-Test: 05051-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           NITROFURANTOIN                                      Date: 05/06/97  
Route: DOSED FEED                                                                                                 Time: 13:25:52  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 5| 6| 7| 7| 4| 7| 7| 7| 7| 6| 6| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 6| 7| 7|            |
                             DAY ON TEST   | 2| 6| 7| 3| 2| 8| 0| 1| 3| 3| 3| 8| 2| 2| 3| 4| 2| 3| 3| 3| 4| 5| 7| 3| 3|            |
                                           | 0| 1| 9| 4| 7| 3| 0| 2| 4| 4| 0| 7| 2| 6| 4| 8| 8| 0| 4| 4| 4| 6| 1| 0| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    0.13%                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Suppurative            |                                                                          |      1  2.0|
      Mineralization                       |                                                                          |      2  2.5|
      Nephropathy, Chronic                 |    3  4  3  4  1  2  2  3  4  4  4  4  4  4  2  3  3  3  3  4  3  4  4  3|     48  3.3|
      Cortex, Cyst                         |                            X                                             |      2     |
      Cortex, Cyst, Multiple               |                                  X                                       |      3     |
      Pelvis, Hydronephrosis               |                            3           2  3                              |      5  3.0|
      Pelvis, Transitional Epithelium,     |                                                                          |            |
           Hyperplasia                     |                         2                 2           3                  |      5  2.4|
      Renal Tubule, Hyperplasia, Focal     |                                                                   2      |      2  2.0|
      Renal Tubule, Pigmentation,          |                                                                          |            |
          Hemosiderin                      |                               4                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mucosa, Hyperplasia                  |                                                                          |      1  3.0|
      Mucosa, Inflammation, Chronic        |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
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