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https://ntp.niehs.nih.gov/go/2463

TR 346 Mouse Pathology Tables


                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                           ETHYL CHLORIDE


NTP Experiment-Test: 05078-02                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:10:53




       Facility:  Battelle Northwest

       Chemical CAS #:  75-00-3

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05078-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:10:53  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        CONTROL      15000 PP                                                            
                                                                M                                                                   
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           50                                                               
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 9           30                                                               
    Natural Death                                      6           18                                                               
    Accidently Killed                                  2                                                                            
  Survivors                                                                                                                         
    Terminal Sacrifice                                32            2                                                               
  Missing                                              1                                                                            
  Animals Examined Microscopically                    49           50                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (49)         (50)                                                             
      Hyperkeratosis                                   1 (2%)                                                                       
   Gallbladder                                        (39)         (32)                                                             
      Inflammation, Chronic                            2 (5%)                                                                       
      Inflammation, Suppurative                                     1 (3%)                                                          
      Wall, Necrosis                                                1 (3%)                                                          
   Intestine Large                                    (48)         (45)                                                             
      Anus, Ulcer                                      1 (2%)                                                                       
   Intestine Large, Cecum                             (41)         (41)                                                             
      Inflammation, Acute                                           1 (2%)                                                          
      Inflammation, Necrotizing                                     1 (2%)                                                          
   Intestine Large, Colon                             (47)         (44)                                                             
      Inflammation, Necrotizing                                     1 (2%)                                                          
   Intestine Small, Duodenum                          (44)         (41)                                                             
      Fibrosis                                                      1 (2%)                                                          
   Intestine Small, Ileum                             (44)         (42)                                                             
      Atrophy                                                       1 (2%)                                                          
   Liver                                              (49)         (48)                                                             
      Basophilic Focus                                 1 (2%)                                                                       
      Eosinophilic Focus                                            2 (4%)                                                          
      Focal Cellular Change                                         2 (4%)                                                          
      Hematopoietic Cell Proliferation                 7 (14%)      3 (6%)                                                          
      Inclusion Body Intranuclear                                   2 (4%)                                                          
      Infarct                                                       1 (2%)                                                          
      Inflammation, Chronic                            1 (2%)                                                                       
      Necrosis                                         1 (2%)       7 (15%)                                                         
   Pancreas                                           (48)         (49)                                                             
      Atrophy                                          2 (4%)       1 (2%)                                                          
      Fibrosis                                                      2 (4%)                                                          
      Inflammation, Chronic                            4 (8%)       2 (4%)                                                          
      Inflammation, Necrotizing                                     2 (4%)                                                          
      Karyomegaly                                                   2 (4%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05078-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:10:53  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        CONTROL      15000 PP                                                            
                                                                M                                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
   Salivary Glands                                    (48)         (47)                                                             
      Inflammation, Chronic                           12 (25%)      3 (6%)                                                          
   Stomach, Forestomach                               (48)         (48)                                                             
      Acanthosis                                                    1 (2%)                                                          
      Hemorrhage, Acute                                             1 (2%)                                                          
      Hyperkeratosis                                   1 (2%)       9 (19%)                                                         
   Stomach, Glandular                                 (49)         (47)                                                             
      Cyst                                             1 (2%)                                                                       
      Metaplasia, Focal, Squamous                      1 (2%)       1 (2%)                                                          
      Necrosis, Coagulative                                         1 (2%)                                                          
      Ulcer                                            1 (2%)                                                                       
      Mucosa, Dilatation                                            1 (2%)                                                          
   Tooth                                              (1)                                                                           
      Peridontal Tissue, Abscess                       1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (49)         (50)                                                             
      Coronary Artery, Inflammation, Chronic           1 (2%)       1 (2%)                                                          
      Endocardium, Thrombosis                                       1 (2%)                                                          
      Myocardium, Fibrosis                                          2 (4%)                                                          
      Myocardium, Mineralization                                    1 (2%)                                                          
      Myocardium, Necrosis                                          1 (2%)                                                          
      Valve, Degeneration, Mucoid                      7 (14%)      7 (14%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (49)         (48)                                                             
      Capsule, Inflammation, Necrotizing               1 (2%)       1 (2%)                                                          
      Subcapsular, Hyperplasia                        45 (92%)     45 (94%)                                                         
   Adrenal Gland, Cortex                              (49)         (48)                                                             
      Accessory Adrenal Cortical Nodule                             1 (2%)                                                          
      Atrophy                                          1 (2%)                                                                       
      Congestion                                                    1 (2%)                                                          
      Cyst                                                          1 (2%)                                                          
      Degeneration                                    40 (82%)     25 (52%)                                                         
      Fibrosis                                        40 (82%)     21 (44%)                                                         
      Hematopoietic Cell Proliferation                              3 (6%)                                                          
      Hemorrhage, Acute                                             1 (2%)                                                          
      Hyperplasia                                      2 (4%)                                                                       
      Inflammation, Chronic                                         1 (2%)                                                          
      Inflammation, Suppurative                                     1 (2%)                                                          
   Adrenal Gland, Medulla                             (49)         (47)                                                             
      Cyst                                                          2 (4%)                                                          
      Hyperplasia                                      1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05078-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:10:53  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        CONTROL      15000 PP                                                            
                                                                M                                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
   Islets, Pancreatic                                 (48)         (49)                                                             
      Atrophy                                                       3 (6%)                                                          
      Inflammation, Chronic                            1 (2%)                                                                       
   Pituitary Gland                                    (49)         (45)                                                             
      Cyst                                                          1 (2%)                                                          
      Pars Distalis, Cyst                                           1 (2%)                                                          
      Pars Distalis, Hemorrhage                        1 (2%)                                                                       
      Pars Distalis, Hyperplasia                      10 (20%)      4 (9%)                                                          
      Pars Distalis, Hyperplasia, Focal                2 (4%)                                                                       
   Thyroid Gland                                      (48)         (48)                                                             
      Atrophy                                          1 (2%)                                                                       
      Follicular Cell, Hyperplasia                     2 (4%)                                                                       
      Follicular Cell, Hyperplasia, Focal              2 (4%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (1)                                                                           
      Cyst Multilocular                                1 (100%)                                                                     
   Ovary                                              (49)         (48)                                                             
      Abscess                                          1 (2%)                                                                       
      Atrophy                                          1 (2%)                                                                       
      Cyst                                            17 (35%)     12 (25%)                                                         
      Inflammation, Chronic                            1 (2%)       1 (2%)                                                          
      Inflammation, Suppurative                        1 (2%)                                                                       
      Necrosis, Liquifactive                           1 (2%)                                                                       
      Corpus Luteum, Cyst                                           1 (2%)                                                          
      Periovarian Tissue, Inflammation, Chronic        4 (8%)       1 (2%)                                                          
   Uterus                                             (49)         (50)                                                             
      Inflammation, Necrotizing                                     1 (2%)                                                          
      Endometrium, Hyperplasia                         2 (4%)                                                                       
      Endometrium, Hyperplasia, Cystic                39 (80%)      6 (12%)                                                         
      Endometrium, Inflammation, Chronic               1 (2%)                                                                       
      Endometrium, Inflammation, Suppurative           3 (6%)       2 (4%)                                                          
      Lymphatic, Ectasia                                            1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05078-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:10:53  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        CONTROL      15000 PP                                                            
                                                                M                                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (49)         (50)                                                             
      Hyperplasia                                                   2 (4%)                                                          
      Myelofibrosis                                   36 (73%)      6 (12%)                                                         
   Lymph Node                                         (46)         (45)                                                             
      Infiltration Cellular, Histiocyte                1 (2%)                                                                       
      Mediastinal, Hyperplasia, Chronic, Lymphoid      1 (2%)                                                                       
      Mesenteric, Edema, Acute                         1 (2%)                                                                       
      Mesenteric, Hemorrhage, Acute                    1 (2%)                                                                       
      Mesenteric, Infiltration Cellular, Histiocyte    1 (2%)                                                                       
      Sinus, Ectasia                                                1 (2%)                                                          
   Lymph Node, Bronchial                              (37)         (38)                                                             
      Erythrophagocytosis                                           1 (3%)                                                          
      Hemorrhage                                                    1 (3%)                                                          
      Hyperplasia, Lymphoid                            3 (8%)       2 (5%)                                                          
      Infiltration Cellular, Histiocyte                2 (5%)       2 (5%)                                                          
   Lymph Node, Mandibular                             (41)         (26)                                                             
      Ectasia                                          1 (2%)                                                                       
      Erythrophagocytosis                                           2 (8%)                                                          
      Hyperplasia, Lymphoid                            3 (7%)                                                                       
      Infiltration Cellular, Histiocyte               14 (34%)      4 (15%)                                                         
      Inflammation, Chronic                                         1 (4%)                                                          
      Inflammation, Subacute                                        1 (4%)                                                          
   Spleen                                             (49)         (49)                                                             
      Atrophy                                          1 (2%)                                                                       
      Erythrophagocytosis                              2 (4%)                                                                       
      Hematopoietic Cell Proliferation                11 (22%)     17 (35%)                                                         
      Hyperplasia, Lymphoid                            4 (8%)       2 (4%)                                                          
   Thymus                                             (39)         (25)                                                             
      Cyst                                             1 (3%)       1 (4%)                                                          
      Infiltration Cellular                                         1 (4%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (42)         (38)                                                             
      Inflammation                                     2 (5%)       2 (5%)                                                          
      Duct, Ectasia                                    3 (7%)       3 (8%)                                                          
   Skin                                               (48)         (50)                                                             
      Epidermis, Atrophy                               1 (2%)       1 (2%)                                                          
      Hair Follicle, Atrophy                          14 (29%)     19 (38%)                                                         
      Subcutaneous Tissue, Edema                                    1 (2%)                                                          
      Subcutaneous Tissue, Infiltration Cellular,                                                                                   
           Histiocyte                                               1 (2%)                                                          
      Subcutaneous Tissue, Inflammation, Chronic                    1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05078-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:10:53  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        CONTROL      15000 PP                                                            
                                                                M                                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (49)         (50)                                                             
      Cranium, Developmental Malformation              1 (2%)                                                                       
   Skeletal Muscle                                    (2)          (2)                                                              
      Intercostal, Abscess                             1 (50%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (49)         (50)                                                             
      Hemorrhage, Acute                                1 (2%)                                                                       
      Inflammation, Chronic                                         1 (2%)                                                          
      Cerebrum, Infiltration Cellular, Histiocyte      1 (2%)                                                                       
      Thalamus, Mineralization                         9 (18%)     10 (20%)                                                         
      Ventricle, Dilatation                            1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (46)         (49)                                                             
      Epithelium, Hyperplasia, Focal                                1 (2%)                                                          
   Lung                                               (49)         (50)                                                             
      Hemorrhage                                                    5 (10%)                                                         
      Inflammation, Acute                              1 (2%)      12 (24%)                                                         
      Inflammation, Chronic, Multifocal               23 (47%)      1 (2%)                                                          
      Inflammation, Subacute                                        1 (2%)                                                          
      Metaplasia, Osseous                                           1 (2%)                                                          
      Thrombosis                                                    2 (4%)                                                          
      Alveolar Epithelium, Hyperplasia, Diffuse                     1 (2%)                                                          
      Alveolus, Adenomatosis, Focal                                 2 (4%)                                                          
      Alveolus, Edema                                               1 (2%)                                                          
      Alveolus, Erythrophagocytosis                                 2 (4%)                                                          
      Alveolus, Infiltration Cellular, Histiocyte      1 (2%)       6 (12%)                                                         
      Bronchiole, Hyperplasia, Multifocal              1 (2%)       1 (2%)                                                          
      Bronchus, Inflammation, Suppurative              1 (2%)                                                                       
      Glands, Ectasia                                  2 (4%)       1 (2%)                                                          
      Interstitium, Inflammation, Chronic                           1 (2%)                                                          
      Interstitium, Inflammation, Subacute                          1 (2%)                                                          
      Pleura, Inflammation, Chronic                                 1 (2%)                                                          
      Vein, Metaplasia, Focal, Osseous                 1 (2%)                                                                       
   Nose                                               (49)         (50)                                                             
      Glands, Dilatation                                            2 (4%)                                                          
      Mucosa, Hyperplasia                                           1 (2%)                                                          
      Mucosa, Inflammation, Suppurative                2 (4%)       1 (2%)                                                          
      Nasolacrimal Duct, Hyperplasia                                1 (2%)                                                          
      Nasolacrimal Duct, Inflammation, Suppurative                  1 (2%)                                                          
      Respiratory Epithelium, Hyperplasia              2 (4%)       2 (4%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05078-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:10:53  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        CONTROL      15000 PP                                                            
                                                                M                                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Respiratory Epithelium, Metaplasia, Squamous     1 (2%)       2 (4%)                                                          
      Submucosa, Inflammation, Chronic, Diffuse                     1 (2%)                                                          
   Trachea                                            (46)         (49)                                                             
      Glands, Dilatation                               1 (2%)       1 (2%)                                                          
      Submucosa, Inflammation, Chronic                 1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (49)         (47)                                                             
      Cyst                                                          1 (2%)                                                          
      Hematopoietic Cell Proliferation                 1 (2%)       1 (2%)                                                          
      Hydronephrosis                                                6 (13%)                                                         
      Hypoplasia                                       1 (2%)                                                                       
      Inflammation, Chronic                            8 (16%)                                                                      
      Inflammation, Suppurative                        2 (4%)                                                                       
      Nephropathy                                     10 (20%)     20 (43%)                                                         
      Capsule, Inflammation, Suppurative               1 (2%)                                                                       
      Glomerulus, Amyloid Deposition                                1 (2%)                                                          
      Renal Tubule, Karyomegaly                                     5 (11%)                                                         
      Renal Tubule, Mineralization                                  1 (2%)                                                          
      Renal Tubule, Pigmentation, Bile                              2 (4%)                                                          
   Ureter                                                          (2)                                                              
      Transitional Epithelium, Necrosis                             1 (50%)                                                         
   Urinary Bladder                                    (46)         (43)                                                             
      Edema                                                         1 (2%)                                                          
      Inflammation, Chronic                           17 (37%)      5 (12%)                                                         
      Inflammation, Necrotizing                                     1 (2%)                                                          
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05078-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:10:53  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          CONTROL      15000 PP                                                            
                                                                M                                                                   
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           50                                                               
  Early Deaths                                                                                                                      
    Natural Death                                      7           14                                                               
    Moribund Sacrifice                                15           25                                                               
  Survivors                                                                                                                         
    Terminal Sacrifice                                28           11                                                               
  Animals Examined Microscopically                    50           50                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (50)         (48)                                                             
      Hyperkeratosis                                                1 (2%)                                                          
   Gallbladder                                        (40)         (31)                                                             
      Inflammation, Chronic                            1 (3%)                                                                       
      Mucosa, Hyperplasia                                           1 (3%)                                                          
   Intestine Large                                    (46)         (45)                                                             
      Anus, Necrosis, Focal                                         1 (2%)                                                          
   Intestine Small, Duodenum                          (45)         (42)                                                             
      Ulcer                                                         1 (2%)                                                          
   Intestine Small, Ileum                             (44)         (43)                                                             
      Inflammation, Subacute                                        1 (2%)                                                          
   Liver                                              (50)         (47)                                                             
      Basophilic Focus                                              1 (2%)                                                          
      Hematopoietic Cell Proliferation                 2 (4%)       3 (6%)                                                          
      Infiltration Cellular, Focal, Histiocyte         1 (2%)                                                                       
      Inflammation, Acute                                           1 (2%)                                                          
      Mineralization, Focal                                         1 (2%)                                                          
      Necrosis                                         2 (4%)       5 (11%)                                                         
      Hepatocyte, Cytomegaly                           1 (2%)                                                                       
   Mesentery                                                       (3)                                                              
      Inflammation, Suppurative                                     1 (33%)                                                         
   Pancreas                                           (49)         (47)                                                             
      Hyperplasia                                                   2 (4%)                                                          
   Salivary Glands                                    (49)         (48)                                                             
      Inflammation, Chronic                            7 (14%)      7 (15%)                                                         
   Stomach, Forestomach                               (49)         (48)                                                             
      Hyperkeratosis                                   1 (2%)       2 (4%)                                                          
      Epithelium, Hyperplasia                                       2 (4%)                                                          
   Stomach, Glandular                                 (49)         (48)                                                             
      Atrophy                                          1 (2%)                                                                       
      Cyst                                             1 (2%)       1 (2%)                                                          
      Hyperplasia                                      1 (2%)                                                                       
      Inflammation, Chronic                                         1 (2%)                                                          
      Metaplasia, Squamous                             1 (2%)       4 (8%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05078-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:10:53  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          CONTROL      15000 PP                                                            
                                                                M                                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Mineralization                                                1 (2%)                                                          
      Mucosa, Necrosis                                 1 (2%)                                                                       
   Tooth                                              (2)                                                                           
      Abscess                                          1 (50%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (48)                                                             
      Coronary Artery, Inflammation, Chronic           2 (4%)                                                                       
      Coronary Artery, Mineralization                  1 (2%)                                                                       
      Valve, Degeneration                                           2 (4%)                                                          
      Valve, Degeneration, Mucoid                      7 (14%)      8 (17%)                                                         
      Valve, Mineralization                                         1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (47)         (47)                                                             
      Capsule, Inflammation, Necrotizing               1 (2%)                                                                       
      Subcapsular, Hyperplasia                        23 (49%)     27 (57%)                                                         
   Adrenal Gland, Cortex                              (46)         (46)                                                             
      Degeneration, Focal                                           1 (2%)                                                          
      Hematopoietic Cell Proliferation                              1 (2%)                                                          
      Hyperplasia, Focal                               1 (2%)       2 (4%)                                                          
      Hypertrophy, Focal                                            1 (2%)                                                          
   Adrenal Gland, Medulla                             (47)         (47)                                                             
      Cyst                                                          1 (2%)                                                          
   Islets, Pancreatic                                 (49)         (48)                                                             
      Atrophy                                                       1 (2%)                                                          
   Pituitary Gland                                    (47)         (44)                                                             
      Pars Distalis, Hyperplasia                       1 (2%)                                                                       
   Thyroid Gland                                      (49)         (48)                                                             
      Cyst                                             1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (1)          (3)                                                              
      Hemorrhage, Focal                                1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05078-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:10:53  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          CONTROL      15000 PP                                                            
                                                                M                                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (46)         (39)                                                             
      Inflammation, Necrotizing                        1 (2%)                                                                       
   Penis                                              (3)          (8)                                                              
      Inflammation, Suppurative                        1 (33%)      2 (25%)                                                         
      Necrosis                                         2 (67%)      6 (75%)                                                         
      Endothelium, Hyperplasia,                                                                                                     
          Pseudoepitheliomatous                                     1 (13%)                                                         
   Preputial Gland                                    (19)         (24)                                                             
      Abscess                                          3 (16%)      1 (4%)                                                          
      Cyst                                             6 (32%)     11 (46%)                                                         
      Hyperplasia                                                   2 (8%)                                                          
      Inflammation, Chronic                            1 (5%)       4 (17%)                                                         
      Inflammation, Necrotizing                                     3 (13%)                                                         
      Inflammation, Suppurative                                     5 (21%)                                                         
   Prostate                                           (49)         (43)                                                             
      Inflammation, Chronic                            1 (2%)       2 (5%)                                                          
      Inflammation, Suppurative                        1 (2%)       2 (5%)                                                          
   Seminal Vesicle                                    (46)         (41)                                                             
      Dilatation                                       3 (7%)      10 (24%)                                                         
      Inflammation, Chronic                                         2 (5%)                                                          
      Inflammation, Necrotizing                        1 (2%)                                                                       
      Inflammation, Suppurative                        1 (2%)       1 (2%)                                                          
   Testes                                             (48)         (47)                                                             
      Atrophy                                          4 (8%)       9 (19%)                                                         
      Inflammation, Suppurative                                     1 (2%)                                                          
      Vein, Angiectasis                                1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node                                         (38)         (39)                                                             
      Infiltration Cellular, Histiocyte                1 (3%)                                                                       
      Mediastinal, Sinus, Infiltration Cellular                     1 (3%)                                                          
      Mesenteric, Infiltration Cellular, Histiocyte                 1 (3%)                                                          
      Renal, Inflammation, Acute                                    1 (3%)                                                          
   Lymph Node, Bronchial                              (29)         (30)                                                             
      Infiltration Cellular, Histiocyte                1 (3%)       2 (7%)                                                          
   Lymph Node, Mandibular                             (19)         (22)                                                             
      Ectasia                                          1 (5%)                                                                       
      Erythrophagocytosis                                           1 (5%)                                                          
      Hyperplasia                                                   1 (5%)                                                          
      Hyperplasia, Lymphoid                                         1 (5%)                                                          
      Infiltration Cellular, Histiocyte                4 (21%)      3 (14%)                                                         
   Spleen                                             (49)         (48)                                                             
      Atrophy                                          1 (2%)       1 (2%)                                                          
      Congestion, Acute                                             1 (2%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05078-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:10:53  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          CONTROL      15000 PP                                                            
                                                                M                                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Fibrosis                                         1 (2%)                                                                       
      Hematopoietic Cell Proliferation                 6 (12%)      9 (19%)                                                         
      Hemorrhage                                       1 (2%)                                                                       
      Hemorrhage, Chronic                              1 (2%)                                                                       
      Hyperplasia, Lymphoid                            2 (4%)                                                                       
   Thymus                                             (33)         (33)                                                             
      Cyst                                                          1 (3%)                                                          
      Necrosis, Multiple                               1 (3%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (18)         (15)                                                             
      Inflammation, Chronic                            1 (6%)                                                                       
      Duct, Ectasia                                    1 (6%)                                                                       
   Skin                                               (50)         (49)                                                             
      Hyperplasia, Lymphoid                                         1 (2%)                                                          
      Hair Follicle, Atrophy                          11 (22%)      6 (12%)                                                         
      Hair Follicle, Degeneration                      1 (2%)                                                                       
      Hair Follicle, Ectasia                           1 (2%)                                                                       
      Prepuce, Abscess                                 3 (6%)                                                                       
      Prepuce, Cyst                                                 1 (2%)                                                          
      Prepuce, Hyperkeratosis                                       1 (2%)                                                          
      Prepuce, Inflammation, Chronic                                3 (6%)                                                          
      Prepuce, Inflammation, Necrotizing               1 (2%)       2 (4%)                                                          
      Prepuce, Inflammation, Suppurative               1 (2%)       4 (8%)                                                          
      Prepuce, Ulcer                                  10 (20%)     18 (37%)                                                         
      Subcutaneous Tissue, Hyperplasia, Lymphoid       1 (2%)       1 (2%)                                                          
      Subcutaneous Tissue, Infiltration Cellular,                                                                                   
           Histiocyte                                  1 (2%)                                                                       
      Subcutaneous Tissue, Inflammation, Acute                      1 (2%)                                                          
      Subcutaneous Tissue, Inflammation, Chronic       1 (2%)       1 (2%)                                                          
      Subcutaneous Tissue, Inflammation,                                                                                            
          Suppurative                                  1 (2%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                    (2)                                                                           
      Inflammation, Necrotizing                        1 (50%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
NTP Experiment-Test: 05078-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:10:53  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          CONTROL      15000 PP                                                            
                                                                M                                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (48)                                                             
      Infiltration Cellular, Focal, Lymphocyte         1 (2%)                                                                       
      Inflammation, Suppurative                                     1 (2%)                                                          
      Thalamus, Mineralization                        19 (38%)     17 (35%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (50)         (48)                                                             
      Dilatation                                       1 (2%)                                                                       
      Submucosa, Cyst                                               1 (2%)                                                          
      Submucosa, Inflammation, Chronic                 1 (2%)                                                                       
   Lung                                               (50)         (48)                                                             
      Bronchiectasis                                   1 (2%)                                                                       
      Hemorrhage                                       1 (2%)       1 (2%)                                                          
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
      Inflammation, Acute                              1 (2%)       1 (2%)                                                          
      Inflammation, Chronic, Multifocal                9 (18%)      2 (4%)                                                          
      Inflammation, Chronic Active                     1 (2%)                                                                       
      Alveolar Epithelium, Hyperplasia, Focal                       1 (2%)                                                          
      Alveolus, Adenomatosis, Focal                    1 (2%)                                                                       
      Alveolus, Infiltration Cellular, Histiocyte      1 (2%)                                                                       
      Bronchiole, Hyperplasia, Multifocal                           1 (2%)                                                          
      Glands, Ectasia                                  3 (6%)       4 (8%)                                                          
      Interstitium, Inflammation, Chronic                           1 (2%)                                                          
      Submucosa, Bronchus, Glands, Ectasia                          1 (2%)                                                          
   Nose                                               (50)         (49)                                                             
      Glands, Cyst                                     2 (4%)       1 (2%)                                                          
      Glands, Hyperplasia                              1 (2%)                                                                       
      Nasolacrimal Duct, Inflammation, Suppurative     1 (2%)                                                                       
      Olfactory Epithelium, Hyperplasia                             1 (2%)                                                          
      Septum, Developmental Malformation                            1 (2%)                                                          
      Submucosa, Inflammation, Chronic                              3 (6%)                                                          
   Trachea                                            (50)         (47)                                                             
      Glands, Dilatation                                            4 (9%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (2)          (2)                                                              
      Cornea, Inflammation, Subacute                   1 (50%)                                                                      
      Cornea, Necrosis, Focal                          1 (50%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   12                                                              
NTP Experiment-Test: 05078-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:10:53  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          CONTROL      15000 PP                                                            
                                                                M                                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (49)                                                             
      Cyst                                             1 (2%)                                                                       
      Hydronephrosis                                                1 (2%)                                                          
      Infarct                                                       2 (4%)                                                          
      Inflammation, Chronic                            1 (2%)       2 (4%)                                                          
      Inflammation, Suppurative                        2 (4%)       8 (16%)                                                         
      Necrosis                                                      3 (6%)                                                          
      Nephropathy                                     27 (54%)     21 (43%)                                                         
      Capsule, Inflammation, Necrotizing               1 (2%)                                                                       
      Pelvis, Inflammation, Suppurative                2 (4%)       1 (2%)                                                          
      Renal Tubule, Karyomegaly                                    40 (82%)                                                         
      Renal Tubule, Mineralization                                  1 (2%)                                                          
   Ureter                                             (1)          (1)                                                              
      Mucosa, Inflammation, Chronic                                 1 (100%)                                                        
   Urinary Bladder                                    (47)         (47)                                                             
      Inflammation, Acute                              1 (2%)       2 (4%)                                                          
      Inflammation, Chronic                            2 (4%)       3 (6%)                                                          
      Inflammation, Necrotizing                                     1 (2%)                                                          
      Inflammation, Suppurative                        2 (4%)       2 (4%)                                                          
      Lumen, Concretion                                             1 (2%)                                                          
      Transitional Epithelium, Hyperplasia             1 (2%)       2 (4%)                                                          
      Transitional Epithelium, Necrosis                             6 (13%)                                                         
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   13                                                              
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