National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/2467

TR 346 Mouse Pathology Tables


                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                           ETHYL CHLORIDE


NTP Experiment-Test: 05078-02                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:10:54




       Facility:  Battelle Northwest

       Chemical CAS #:  75-00-3

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05078-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:10:54  
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         B6C3F1 MICE FEMALE                        CONTROL      15000 PP                                                            
                                                                M                                                                   
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DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50                                                               
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 9           30                                                               
    Natural Death                                      6           18                                                               
    Accidently Killed                                  2                                                                            
  Survivors                                                                                                                         
    Terminal Sacrifice                                32            2                                                               
  Missing                                              1                                                                            
  Animals Examined Microscopically                    49           50                                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (39)         (32)                                                             
      Carcinoma, Metastatic                                         1 (3%)                                                          
      Carcinoma, Metastatic, Uterus                                 1 (3%)                                                          
   Intestine Large, Cecum                             (41)         (41)                                                             
   Intestine Large, Colon                             (47)         (44)                                                             
      Carcinoma, Metastatic, Uterus                                 2 (5%)                                                          
   Intestine Large, Rectum                            (46)         (44)                                                             
   Intestine Small, Duodenum                          (44)         (41)                                                             
   Intestine Small, Ileum                             (44)         (42)                                                             
      Carcinoma, Metastatic, Uterus                                 1 (2%)                                                          
   Intestine Small, Jejunum                           (44)         (40)                                                             
   Liver                                              (49)         (48)                                                             
      Carcinoma, Metastatic, Uterus                                 1 (2%)                                                          
      Hepatocellular Carcinoma                         3 (6%)       5 (10%)                                                         
      Hepatocellular Carcinoma, Multiple                            2 (4%)                                                          
      Hepatocellular Adenoma                                        1 (2%)                                                          
   Mesentery                                                       (12)                                                             
      Carcinoma, Multiple, Metastatic, Uterus                       2 (17%)                                                         
      Carcinoma, Metastatic, Uncertain Primary Site                 1 (8%)                                                          
      Carcinoma, Metastatic, Uterus                                 5 (42%)                                                         
   Pancreas                                           (48)         (49)                                                             
      Carcinoma, Metastatic, Uterus                                 7 (14%)                                                         
   Salivary Glands                                    (48)         (47)                                                             
   Stomach, Forestomach                               (48)         (48)                                                             
      Squamous Cell Papilloma                                       2 (4%)                                                          
   Stomach, Glandular                                 (49)         (47)                                                             
      Carcinoma, Metastatic, Uterus                                 1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   2                                                               
NTP Experiment-Test: 05078-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:10:54  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      15000 PP                                                            
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 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (49)         (50)                                                             
      Carcinoma, Multiple, Metastatic, Uterus                       1 (2%)                                                          
      Carcinoma, Metastatic, Uterus                                 3 (6%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (49)         (48)                                                             
      Capsule, Carcinoma, Metastatic, Uterus                        4 (8%)                                                          
   Adrenal Gland, Cortex                              (49)         (48)                                                             
      Carcinoma, Metastatic, Uterus                                 4 (8%)                                                          
   Adrenal Gland, Medulla                             (49)         (47)                                                             
      Carcinoma, Metastatic, Uterus                                 1 (2%)                                                          
      Pheochromocytoma NOS                             1 (2%)       2 (4%)                                                          
   Islets, Pancreatic                                 (48)         (49)                                                             
   Pituitary Gland                                    (49)         (45)                                                             
      Pars Distalis, Adenoma                          11 (22%)      1 (2%)                                                          
   Thyroid Gland                                      (48)         (48)                                                             
      Follicular Cell, Adenoma                                      2 (4%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (2)          (4)                                                              
      Adenoacanthoma, Metastatic, Mammary Gland        1 (50%)                                                                      
      Carcinoma, Metastatic, Uterus                                 2 (50%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (49)         (48)                                                             
      Adenocarcinoma                                                1 (2%)                                                          
      Carcinoma, Multiple, Metastatic, Uterus                       1 (2%)                                                          
      Carcinoma, Metastatic, Uterus                                21 (44%)                                                         
   Uterus                                             (49)         (50)                                                             
      Carcinoma                                        1 (2%)      42 (84%)                                                         
      Carcinoma, Multiple                                           1 (2%)                                                          
      Fibrosarcoma                                                  1 (2%)                                                          
      Cervix, Polyp                                    1 (2%)                                                                       
      Endometrium, Polyp Stromal                       1 (2%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   3                                                               
NTP Experiment-Test: 05078-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:10:54  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      15000 PP                                                            
                                                                M                                                                   
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 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (49)         (50)                                                             
   Lymph Node                                         (46)         (45)                                                             
      Carcinoma, Metastatic, Uterus                                 1 (2%)                                                          
      Mesenteric, Carcinoma, Metastatic, Uterus                     1 (2%)                                                          
      Renal, Carcinoma, Metastatic, Uterus                          2 (4%)                                                          
   Lymph Node, Bronchial                              (37)         (38)                                                             
      Adenoacanthoma, Metastatic, Mammary Gland        1 (3%)                                                                       
      Carcinoma, Multiple, Metastatic, Uterus                       1 (3%)                                                          
      Carcinoma, Metastatic, Uterus                                13 (34%)                                                         
   Lymph Node, Mandibular                             (41)         (26)                                                             
   Spleen                                             (49)         (49)                                                             
      Carcinoma, Metastatic, Uterus                                 5 (10%)                                                         
   Thymus                                             (39)         (25)                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (42)         (38)                                                             
      Adenoacanthoma                                   1 (2%)       1 (3%)                                                          
      Adenocarcinoma                                   2 (5%)                                                                       
   Skin                                               (48)         (50)                                                             
      Sarcoma                                          1 (2%)                                                                       
      Subcutaneous Tissue, Hemangiosarcoma             1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (49)         (50)                                                             
      Cranium, Osteosarcoma                            1 (2%)                                                                       
   Skeletal Muscle                                    (2)          (2)                                                              
      Adenoacanthoma, Metastatic, Mammary Gland        1 (50%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (49)         (50)                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (46)         (49)                                                             
   Lung                                               (49)         (50)                                                             
      Adenoacanthoma, Multiple, Metastatic,                                                                                         
          Mammary Gland                                1 (2%)                                                                       
      Alveolar/Bronchiolar Adenoma                     1 (2%)       2 (4%)                                                          
      Alveolar/Bronchiolar Adenoma, Multiple           1 (2%)                                                                       
                                                             Page   4                                                               
NTP Experiment-Test: 05078-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:10:54  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      15000 PP                                                            
                                                                M                                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - cont                                                                                                           
      Alveolar/Bronchiolar Carcinoma                   2 (4%)       2 (4%)                                                          
      Alveolar/Bronchiolar Carcinoma, Multiple         1 (2%)                                                                       
      Carcinoma, Multiple, Metastatic, Uncertain                                                                                    
          Primary Site                                              1 (2%)                                                          
      Carcinoma, Multiple, Metastatic, Uterus                      11 (22%)                                                         
      Carcinoma, Metastatic, Uterus                                12 (24%)                                                         
   Nose                                               (49)         (50)                                                             
      Mucosa, Adenocarcinoma                                        1 (2%)                                                          
   Trachea                                            (46)         (49)                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                (3)                                                                           
      Squamous Cell Carcinoma                          1 (33%)                                                                      
      Pinna, Fibrosarcoma                              1 (33%)                                                                      
   Harderian Gland                                    (2)          (2)                                                              
      Adenocarcinoma                                                2 (100%)                                                        
      Adenoma                                          2 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (49)         (47)                                                             
      Carcinoma, Metastatic, Uterus                                 8 (17%)                                                         
   Ureter                                                          (2)                                                              
      Carcinoma, Metastatic, Uterus                                 1 (50%)                                                         
   Urinary Bladder                                    (46)         (43)                                                             
      Carcinoma, Metastatic, Uterus                                 7 (16%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(49)        *(50)                                                             
      Leukemia Granulocytic                                         1 (2%)                                                          
      Lymphoma Malignant                               1 (2%)       1 (2%)                                                          
      Lymphoma Malignant Histiocytic                                2 (4%)                                                          
      Lymphoma Malignant Lymphocytic                   2 (4%)       2 (4%)                                                          
      Lymphoma Malignant Mixed                         1 (2%)       3 (6%)                                                          
      Lymphoma Malignant Undifferentiated Cell         1 (2%)       2 (4%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   5                                                               
NTP Experiment-Test: 05078-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:10:54  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      15000 PP                                                            
                                                                M                                                                   
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TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            28          47                                                               
     Total Primary Neoplasms                           38          80                                                               
                                                                                                                                    
   Total Animals with Benign Neoplasms                 15           9                                                               
     Total Benign Neoplasms                            17           9                                                               
                                                                                                                                    
   Total Animals with Malignant Neoplasms              18          47                                                               
     Total Malignant Neoplasms                         20          69                                                               
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              1          35                                                               
     Total Metastatic Neoplasm                          4         122                                                               
                                                                                                                                    
   Total Animals with Malignant Neoplasms                           1                                                               
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                  1           2                                                               
     Total Uncertain Neoplasms                          1           2                                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   6                                                               
NTP Experiment-Test: 05078-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:10:54  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      15000 PP                                                            
                                                                M                                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50                                                               
  Early Deaths                                                                                                                      
    Natural Death                                      7           14                                                               
    Moribund Sacrifice                                15           25                                                               
  Survivors                                                                                                                         
    Terminal Sacrifice                                28           11                                                               
  Animals Examined Microscopically                    50           50                                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (50)         (48)                                                             
      Squamous Cell Carcinoma                          1 (2%)                                                                       
   Intestine Large, Colon                             (46)         (45)                                                             
   Intestine Small, Duodenum                          (45)         (42)                                                             
      Hepatocellular Carcinoma, Metastatic                          1 (2%)                                                          
   Intestine Small, Ileum                             (44)         (43)                                                             
   Liver                                              (50)         (47)                                                             
      Hemangiosarcoma                                               1 (2%)                                                          
      Hepatocellular Carcinoma                         5 (10%)      6 (13%)                                                         
      Hepatocellular Carcinoma, Multiple               4 (8%)       3 (6%)                                                          
      Hepatocellular Adenoma                           5 (10%)      2 (4%)                                                          
      Hepatocellular Adenoma, Multiple                 1 (2%)                                                                       
   Pancreas                                           (49)         (47)                                                             
   Stomach, Forestomach                               (49)         (48)                                                             
   Stomach, Glandular                                 (49)         (48)                                                             
   Tooth                                              (2)                                                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (48)                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (47)         (47)                                                             
   Adrenal Gland, Cortex                              (46)         (46)                                                             
      Adenoma                                          1 (2%)                                                                       
   Islets, Pancreatic                                 (49)         (48)                                                             
      Adenoma                                          1 (2%)                                                                       
   Thyroid Gland                                      (49)         (48)                                                             
      Follicular Cell, Adenoma                                      1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                             Page   7                                                               
NTP Experiment-Test: 05078-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:10:54  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      15000 PP                                                            
                                                                M                                                                   
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 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (46)         (39)                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node                                         (38)         (39)                                                             
   Lymph Node, Bronchial                              (29)         (30)                                                             
      Fibrosarcoma, Metastatic, Skin                   1 (3%)                                                                       
      Hepatocellular Carcinoma, Metastatic, Liver      1 (3%)                                                                       
   Spleen                                             (49)         (48)                                                             
      Hemangiosarcoma                                               1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (49)                                                             
      Hemangiosarcoma                                               1 (2%)                                                          
      Prepuce, Fibrous Histiocytoma                    1 (2%)                                                                       
      Subcutaneous Tissue, Lipoma                                   1 (2%)                                                          
      Subcutaneous Tissue, Head, Fibrosarcoma          1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (48)                                                             
      Cranium, Sternum, Fibrosarcoma, Metastatic,                                                                                   
           Skin                                        1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (48)                                                             
      Alveolar/Bronchiolar Adenoma                     3 (6%)       8 (17%)                                                         
      Alveolar/Bronchiolar Carcinoma                   2 (4%)       1 (2%)                                                          
      Alveolar/Bronchiolar Carcinoma, Multiple                      1 (2%)                                                          
                                                             Page   8                                                               
NTP Experiment-Test: 05078-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:10:54  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      15000 PP                                                            
                                                                M                                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - cont                                                                                                           
      Carcinoma, Metastatic, Harderian Gland           1 (2%)                                                                       
      Fibrosarcoma, Metastatic, Skin                   1 (2%)                                                                       
      Hepatocellular Carcinoma, Multiple,                                                                                           
          Metastatic, Liver                            1 (2%)                                                                       
      Hepatocellular Carcinoma, Metastatic, Liver      1 (2%)                                                                       
   Nose                                               (50)         (49)                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                (1)          (4)                                                              
      Fibrosarcoma                                                  1 (25%)                                                         
      Pinna, Squamous Cell Carcinoma                   1 (100%)                                                                     
   Harderian Gland                                    (5)          (4)                                                              
      Adenocarcinoma                                   1 (20%)                                                                      
      Adenoma                                          2 (40%)      4 (100%)                                                        
      Carcinoma                                        1 (20%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (49)                                                             
   Ureter                                             (1)          (1)                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)                                                             
      Lymphoma Malignant Mixed                                      2 (4%)                                                          
      Lymphoma Malignant Undifferentiated Cell         1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   9                                                               
NTP Experiment-Test: 05078-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:10:54  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      15000 PP                                                            
                                                                M                                                                   
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TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            27          20                                                               
     Total Primary Neoplasms                           31          34                                                               
                                                                                                                                    
   Total Animals with Benign Neoplasms                 12          11                                                               
     Total Benign Neoplasms                            13          17                                                               
                                                                                                                                    
   Total Animals with Malignant Neoplasms              17          13                                                               
     Total Malignant Neoplasms                         18          17                                                               
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              3           1                                                               
     Total Metastatic Neoplasm                          7           1                                                               
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  10                                                               
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