National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/2471

TR 346 Mouse Pathology Tables

NTP Experiment-Test: 05078-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 05/05/97
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:49:45




       Facility:  Battelle Northwest

       Chemical CAS #:  75-00-3

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All






































                                                              Page   1

NTP Experiment-Test: 05078-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 05/05/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:49:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 1| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 5|             
                             DAY ON TEST   | 0| 0| 9| 0| 3| 0| 9| 0| 0| 0| 0| 6| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 2| 0| 0|             
                                           | 1| 1| 2| 1| 2| 1| 6| 1| 1| 1| 1| 5| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 9| 1| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                                                          |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                2                                                         |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Anus, Ulcer                          |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | M  M  +  M  +  +  +  M  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                                          |             
      Hematopoietic Cell Proliferation     |                                     2                             1     2|             
      Inflammation, Chronic                |                                                                          |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Atrophy                              |                                                                          |             
      Inflammation, Chronic                |    2                                                                     |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |    2           2                    2        2     2        2  1         |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                      1                                                   |             
      Metaplasia, Focal, Squamous          |                                                       2                  |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                             +            |             
      Peridontal Tissue, Abscess           |                                                             3            |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Coronary Artery, Inflammation,       |                                                                          |             
          Chronic                          |                         3                                                |             
      Valve, Degeneration, Mucoid          |                2     2              1     1                             2|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Inflammation, Necrotizing   |                                                                         4|             
      Subcapsular, Hyperplasia             | 3  3  2  2     2  2  2  2  2  2  2  2  2  3  2  2  3  3  2  2  2  2     2|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05078-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 05/05/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:49:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 1| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 5|             
                             DAY ON TEST   | 0| 0| 9| 0| 3| 0| 9| 0| 0| 0| 0| 6| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 2| 0| 0|             
                                           | 1| 1| 2| 1| 2| 1| 6| 1| 1| 1| 1| 5| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 9| 1| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Atrophy                              |                                                                      4   |             
      Degeneration                         | 2  1  1  2     2  1  2  1  1  2        1  1  2  2  1  2  2  1  1        2|             
      Fibrosis                             | 2  1  1  1     1  1  2  1  1  1        1  1  1  1  1  2  2  1  1        2|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |    3                                                                     |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M  +  +  +  M  +  +  M  M  M  +  M  M  +  +  +  M  +  +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Hemorrhage            |                      2                                                   |             
      Pars Distalis, Hyperplasia, Focal    |       2  1                                                               |             
      Pars Distalis, Hyperplasia           |                2     2                       3  3                        |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Follicular Cell, Hyperplasia, Focal  |       2                                                                  |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |       +     +                                                            |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |                                                                          |             
      Cyst Multilocular                    |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                          |             
      Atrophy                              |                                        2                                 |             
      Cyst                                 |          2  2        2  2           2     2  2  2           2            |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Necrosis, Liquifactive               |                                                                         4|             
      Periovarian Tissue, Inflammation,    |                                                                          |             
           Chronic                         |                2                                                         |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Endometrium, Hyperplasia, Cystic     | 2  2  2  2        2  2  1     2     1  2  2  2  2  3  2  2  3  2  2  2  2|             
      Endometrium, Hyperplasia             |                                                                          |             
      Endometrium, Inflammation, Chronic   |                                                                          |             
      Endometrium, Inflammation,           |                                                                          |             
          Suppurative                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myelofibrosis                        | 2  1  2  3     2  1  3  2     2     2  3  3  1  2  3     3  2        2   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05078-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 05/05/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:49:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 1| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 5|             
                             DAY ON TEST   | 0| 0| 9| 0| 3| 0| 9| 0| 0| 0| 0| 6| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 2| 0| 0|             
                                           | 1| 1| 2| 1| 2| 1| 6| 1| 1| 1| 1| 5| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 9| 1| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +|             
      Infiltration Cellular, Histiocyte    |                                     1                                    |             
      Mediastinal, Hyperplasia, Chronic,   |                                                                          |             
           Lymphoid                        |                                                                          |             
      Mesenteric, Edema, Acute             |                         3                                                |             
      Mesenteric, Hemorrhage, Acute        |                         3                                                |             
      Mesenteric, Infiltration Cellular,   |                                                                          |             
           Histiocyte                      |                         1                                                |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  M  M  M  +  M  +  M  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                         3|             
      Infiltration Cellular, Histiocyte    |    2                                                                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +|             
      Ectasia                              |                                              1                           |             
      Hyperplasia, Lymphoid                |    2                    3                 2                              |             
      Infiltration Cellular, Histiocyte    |                      2     1                          1     2           2|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Erythrophagocytosis                  |                                                                          |             
      Hematopoietic Cell Proliferation     |             2     2                                            1        3|             
      Hyperplasia, Lymphoid                |    2                                               2                     |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  M  M  +  +  +|             
      Inflammation                         |                                                                         2|             
      Duct, Ectasia                        |                   3                                                     3|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epidermis, Atrophy                   |                                           3                              |             
      Hair Follicle, Atrophy               | 2        2  2              2  3     2  2  3  3              3            |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cranium, Developmental Malformation  |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |             +                                                            |             
      Intercostal, Abscess                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage, Acute                    |                                                                   3      |             
      Cerebrum, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                                  1                                       |             
      Thalamus, Mineralization             | 2        2              2  2        2                                   2|             
      Ventricle, Dilatation                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05078-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 05/05/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:49:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 1| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 5|             
                             DAY ON TEST   | 0| 0| 9| 0| 3| 0| 9| 0| 0| 0| 0| 6| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 2| 0| 0|             
                                           | 1| 1| 2| 1| 2| 1| 6| 1| 1| 1| 1| 5| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 9| 1| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                                         3|             
      Inflammation, Chronic, Multifocal    | 2                          2        3  2  2  2     2  2  1  2  2         |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                                                                          |             
      Bronchiole, Hyperplasia, Multifocal  |                                                                          |             
      Bronchus, Inflammation, Suppurative  |                                                                          |             
      Glands, Ectasia                      |                                                 2                       2|             
      Vein, Metaplasia, Focal, Osseous     |                                                                2         |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mucosa, Inflammation, Suppurative    |                                                                          |             
      Respiratory Epithelium, Hyperplasia  |                                                                          |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Glands, Dilatation                   |                               2                                          |             
      Submucosa, Inflammation, Chronic     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                +                                                         |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                             +            |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                            +        +                                    |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hypoplasia                           |                   4                                                      |             
      Inflammation, Chronic                |    2                 2     2           2     2        2  2               |             
      Inflammation, Suppurative            |                                                                          |             
      Nephropathy                          |          1           1              2                          2     1  2|             
      Capsule, Inflammation, Suppurative   |                                                                         2|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Inflammation, Chronic                | 2              2  2                 2  1  1     2           2            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05078-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 05/05/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:49:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 1| 7| 6| 7| 7| 6| 6| 5| 7| 7| 7| 6| 5| 7| 6| 0| 7| 7| 7| 7| 7| 6| 6|            |
                             DAY ON TEST   | 5| 0| 6| 0| 7| 0| 0| 8| 5| 9| 0| 0| 0| 6| 8| 0| 8| 5| 0| 0| 0| 0| 0| 6| 5|            |
                                           | 7| 1| 6| 1| 1| 1| 1| 2| 1| 7| 1| 1| 1| 3| 7| 1| 8| 2| 1| 1| 1| 1| 1| 8| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|  49        |
      Hyperkeratosis                       |       3                                                                  |      1  3.0|
                                            __________________________________________________________________________|____________|
   Gallbladder                             | M  +  A  +  A  A  M  A  A  +  +  M  +  +  A  +  +     +  +  M  +  +  +  +|  39        |
      Inflammation, Chronic                |    1                                                                     |      2  1.5|
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|  48        |
      Anus, Ulcer                          |                      2                                                   |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +     +  +  +  +  +  +  M|  41        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +     +  +  +  +  +  A  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  M  +  +  +  +  +  A  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  M  +  A  +  +  +  A  +  +  +  +  +  +  +  +     +  +  +  +  +  A  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  M  +  A  +  +  +  A  +  +  +  +  +  +  +  +     +  +  +  +  +  A  +|  44        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  M  +  A  +  +  +  A  +  +  +  +  +  +  +  +     +  +  +  +  +  A  +|  44        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  M  +  A  +  +  +  A  +  +  +  +  +  +  +  +     +  +  +  +  +  A  +|  44        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|  49        |
      Basophilic Focus                     |                            2                                             |      1  2.0|
      Hematopoietic Cell Proliferation     |    1     2                 2                             1               |      7  1.6|
      Inflammation, Chronic                |                                                                      2   |      1  2.0|
      Necrosis                             |                                           2                              |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|  48        |
      Atrophy                              |                         3              4                                 |      2  3.5|
      Inflammation, Chronic                |                      2                                   1           2   |      4  1.8|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +     +  +  +  +  +  +  +|  48        |
      Inflammation, Chronic                | 2  2     2           2                                            2      |     12  1.9|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|  48        |
      Hyperkeratosis                       |       3                                                                  |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|  49        |
      Cyst                                 |                                                                          |      1  1.0|
      Metaplasia, Focal, Squamous          |                                                                          |      1  2.0|
      Ulcer                                |                                                 2                        |      1  2.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
      Peridontal Tissue, Abscess           |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|  49        |
      Coronary Artery, Inflammation,       |                                                                          |            |
          Chronic                          |                                                                          |      1  3.0|
      Valve, Degeneration, Mucoid          |                                              1  2                        |      7  1.6|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   6                                                               
NTP Experiment-Test: 05078-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 05/05/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:49:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 1| 7| 6| 7| 7| 6| 6| 5| 7| 7| 7| 6| 5| 7| 6| 0| 7| 7| 7| 7| 7| 6| 6|            |
                             DAY ON TEST   | 5| 0| 6| 0| 7| 0| 0| 8| 5| 9| 0| 0| 0| 6| 8| 0| 8| 5| 0| 0| 0| 0| 0| 6| 5|            |
                                           | 7| 1| 6| 1| 1| 1| 1| 2| 1| 7| 1| 1| 1| 3| 7| 1| 8| 2| 1| 1| 1| 1| 1| 8| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|  49        |
      Capsule, Inflammation, Necrotizing   |                                                                          |      1  4.0|
      Subcapsular, Hyperplasia             | 3  2  2  2     2  2  1  2  2  3  2  2     2  1  2     2  3  3  2  2  2  2|     45  2.2|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|  49        |
      Atrophy                              |                                                                          |      1  4.0|
      Degeneration                         | 1  1     2     2  1  1  2     2  2  2     2  2  2     2  2  2  2  1  2  1|     40  1.6|
      Fibrosis                             | 1  1     1     2  1  1  1     2  2  1     1  2  2     2  2  2  1  1  1  1|     40  1.3|
      Hyperplasia                          |                         2                                   1            |      2  1.5|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |                                  3                                       |      1  3.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +     +  +  +  +  +  +  +|  48        |
      Inflammation, Chronic                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  M  +  M  +  +  M  M  M  +  M  M  M  +  M  M     +  +  +  +  M  +  M|  27        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|  49        |
      Pars Distalis, Hemorrhage            |                                                                          |      1  2.0|
      Pars Distalis, Hyperplasia, Focal    |                                                                          |      2  1.5|
      Pars Distalis, Hyperplasia           |    2     2        2           3  3           2                           |     10  2.4|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|  48        |
      Atrophy                              |                                                       2                  |      1  2.0|
      Follicular Cell, Hyperplasia, Focal  |                                     1                                    |      2  1.5|
      Follicular Cell, Hyperplasia         |                      2                                   2               |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |                      +                                                   |   1        |
      Cyst Multilocular                    |                      3                                                   |      1  3.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|  49        |
      Abscess                              |                                                                      4   |      1  4.0|
      Atrophy                              |                                                                          |      1  2.0|
      Cyst                                 |                   4  2  2        2        4  2                    3  3   |     17  2.4|
      Inflammation, Chronic                |                2                                                         |      1  2.0|
      Inflammation, Suppurative            |                            4                                             |      1  4.0|
      Necrosis, Liquifactive               |                                                                          |      1  4.0|
      Periovarian Tissue, Inflammation,    |                                                                          |            |
           Chronic                         | 2                                            2  2                        |      4  2.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   7                                                               
NTP Experiment-Test: 05078-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 05/05/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:49:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 1| 7| 6| 7| 7| 6| 6| 5| 7| 7| 7| 6| 5| 7| 6| 0| 7| 7| 7| 7| 7| 6| 6|            |
                             DAY ON TEST   | 5| 0| 6| 0| 7| 0| 0| 8| 5| 9| 0| 0| 0| 6| 8| 0| 8| 5| 0| 0| 0| 0| 0| 6| 5|            |
                                           | 7| 1| 6| 1| 1| 1| 1| 2| 1| 7| 1| 1| 1| 3| 7| 1| 8| 2| 1| 1| 1| 1| 1| 8| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Endometrium, Hyperplasia, Cystic     | 2  2           2  2     2  2  2  2  3  2     2  2     2  4  2  1  2     2|     39  2.1|
      Endometrium, Hyperplasia             |          2           2                                                   |      2  2.0|
      Endometrium, Inflammation, Chronic   |       1                                                                  |      1  1.0|
      Endometrium, Inflammation,           |                                                                          |            |
          Suppurative                      | 3                                                        2           4   |      3  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|  49        |
      Myelofibrosis                        | 2  2     2     3     2  1     2  2  2     2  2  2     1  1  2  2  2     1|     36  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|  46        |
      Infiltration Cellular, Histiocyte    |                                                                          |      1  1.0|
      Mediastinal, Hyperplasia, Chronic,   |                                                                          |            |
           Lymphoid                        | 2                                                                        |      1  2.0|
      Mesenteric, Edema, Acute             |                                                                          |      1  3.0|
      Mesenteric, Hemorrhage, Acute        |                                                                          |      1  3.0|
      Mesenteric, Infiltration Cellular,   |                                                                          |            |
           Histiocyte                      |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +     +  M  +  +  +  +  I|  37        |
      Hyperplasia, Lymphoid                |                            4                                         2   |      3  3.0|
      Infiltration Cellular, Histiocyte    |                                                       1                  |      2  1.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  M  +  +  +  +  +  +  M  +  +  M  +  +  +  +     M  +  +  +  +  +  +|  41        |
      Ectasia                              |                                                                          |      1  1.0|
      Hyperplasia, Lymphoid                |                                                                          |      3  2.3|
      Infiltration Cellular, Histiocyte    |                2  1  2        2  2           1  2        2              2|     14  1.7|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|  49        |
      Atrophy                              |       3                                                                  |      1  3.0|
      Erythrophagocytosis                  |                                                 2     2                  |      2  2.0|
      Hematopoietic Cell Proliferation     |             3           3  2  3        3  2                          3   |     11  2.5|
      Hyperplasia, Lymphoid                |                               4                             3            |      4  2.8|
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  +  M  +  +  +  +  +  +  M  +  +  +  M  +  +  +     M  +  +  +  M  M  M|  39        |
      Cyst                                 |                                                 2                        |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|  42        |
      Inflammation                         |                                        2                                 |      2  2.0|
      Duct, Ectasia                        |                                           2                              |      3  2.7|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|  48        |
      Epidermis, Atrophy                   |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   8                                                               
NTP Experiment-Test: 05078-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 05/05/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:49:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 1| 7| 6| 7| 7| 6| 6| 5| 7| 7| 7| 6| 5| 7| 6| 0| 7| 7| 7| 7| 7| 6| 6|            |
                             DAY ON TEST   | 5| 0| 6| 0| 7| 0| 0| 8| 5| 9| 0| 0| 0| 6| 8| 0| 8| 5| 0| 0| 0| 0| 0| 6| 5|            |
                                           | 7| 1| 6| 1| 1| 1| 1| 2| 1| 7| 1| 1| 1| 3| 7| 1| 8| 2| 1| 1| 1| 1| 1| 8| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hair Follicle, Atrophy               |                   2     2     2        2                                 |     14  2.3|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|  49        |
      Cranium, Developmental Malformation  |                               3                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                            +                                             |   2        |
      Intercostal, Abscess                 |                            2                                             |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|  49        |
      Hemorrhage, Acute                    |                                                                          |      1  3.0|
      Cerebrum, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                                                                          |      1  1.0|
      Thalamus, Mineralization             |             2                       1     2                              |      9  1.9|
      Ventricle, Dilatation                |                                                                         3|      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  I  +  +  +  M  +  +  +  +  +  +  +  +  +  +     +  I  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|  49        |
      Inflammation, Acute                  |                                                                          |      1  3.0|
      Inflammation, Chronic, Multifocal    | 2  2     2  2  2     2              2     2           2  2  1     2      |     23  2.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                                                       3                  |      1  3.0|
      Bronchiole, Hyperplasia, Multifocal  |                                                       3                  |      1  3.0|
      Bronchus, Inflammation, Suppurative  |                            2                                             |      1  2.0|
      Glands, Ectasia                      |                                                                          |      2  2.0|
      Vein, Metaplasia, Focal, Osseous     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|  49        |
      Mucosa, Inflammation, Suppurative    |             2                                         3                  |      2  2.5|
      Respiratory Epithelium, Hyperplasia  |             3                                                           2|      2  2.5|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        |             2                                                            |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  I  +  +  +  +  +  I  +  +  +  +  +  +  I  +     +  +  +  +  +  +  +|  46        |
      Glands, Dilatation                   |                                                                          |      1  2.0|
      Submucosa, Inflammation, Chronic     | 2                                                                        |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |             +           +                                                |   3        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   9                                                               
NTP Experiment-Test: 05078-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 05/05/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:49:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 1| 7| 6| 7| 7| 6| 6| 5| 7| 7| 7| 6| 5| 7| 6| 0| 7| 7| 7| 7| 7| 6| 6|            |
                             DAY ON TEST   | 5| 0| 6| 0| 7| 0| 0| 8| 5| 9| 0| 0| 0| 6| 8| 0| 8| 5| 0| 0| 0| 0| 0| 6| 5|            |
                                           | 7| 1| 6| 1| 1| 1| 1| 2| 1| 7| 1| 1| 1| 3| 7| 1| 8| 2| 1| 1| 1| 1| 1| 8| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|  49        |
      Hematopoietic Cell Proliferation     |                                           2                              |      1  2.0|
      Hypoplasia                           |                                                                          |      1  4.0|
      Inflammation, Chronic                |                                              1                           |      8  1.9|
      Inflammation, Suppurative            |       3                    2                                             |      2  2.5|
      Nephropathy                          |          1        1                          1           1               |     10  1.3|
      Capsule, Inflammation, Suppurative   |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  M  +  +  +  +  +  I  +  +  +  +  +  +     +  +  +  +  +  +  +|  46        |
      Inflammation, Chronic                | 2  2  2  2           1  2                    2        1     1            |     17  1.7|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  10                                                               
NTP Experiment-Test: 05078-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 05/05/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:49:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 6| 5| 6| 6| 6| 6| 5| 6| 5| 6| 6| 6| 6| 6| 5| 6| 6| 5| 4| 6| 6| 6|             
                             DAY ON TEST   | 8| 0| 8| 4| 5| 2| 1| 5| 6| 1| 4| 8| 8| 6| 4| 5| 4| 5| 3| 5| 7| 8| 1| 5| 2|             
                                           | 5| 0| 9| 5| 2| 6| 0| 4| 7| 0| 3| 3| 9| 8| 2| 1| 4| 1| 3| 6| 4| 6| 6| 4| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    15000 PP                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    M                                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  I  +  +  A  +  A  +  +  +  M  +  +  A  +  M  +  +  +  A  A|             
      Inflammation, Suppurative            | 3                                                                        |             
      Wall, Necrosis                       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  M|             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Necrotizing            |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +|             
      Inflammation, Necrotizing            |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  M  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |       1                                                                  |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                     3                                    |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  A  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Eosinophilic Focus                   |                                                       3                  |             
      Focal Cellular Change                |                                                                   2      |             
      Hematopoietic Cell Proliferation     |                4                                                         |             
      Inclusion Body Intranuclear          |                2                                                         |             
      Infarct                              |                         4                                                |             
      Necrosis                             | 1              4                                         4  3           3|             
                                            __________________________________________________________________________|             
   Mesentery                               |          +           +                       +  +     +     +           +|             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Fibrosis                             |                                                                      2   |             
      Inflammation, Chronic                |                                                                      2  2|             
      Inflammation, Necrotizing            |                                                                          |             
      Karyomegaly                          |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M|             
      Inflammation, Chronic                |       1                                         2                        |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                              2                           |             
      Hemorrhage, Acute                    |                                                                          |             
      Hyperkeratosis                       |             2                    1     2     2     2        3        3   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Metaplasia, Focal, Squamous          |                                                                          |             
      Necrosis, Coagulative                |                                  2                                       |             
      Mucosa, Dilatation                   |    2                                                                     |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  11                                                               
NTP Experiment-Test: 05078-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 05/05/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:49:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 6| 5| 6| 6| 6| 6| 5| 6| 5| 6| 6| 6| 6| 6| 5| 6| 6| 5| 4| 6| 6| 6|             
                             DAY ON TEST   | 8| 0| 8| 4| 5| 2| 1| 5| 6| 1| 4| 8| 8| 6| 4| 5| 4| 5| 3| 5| 7| 8| 1| 5| 2|             
                                           | 5| 0| 9| 5| 2| 6| 0| 4| 7| 0| 3| 3| 9| 8| 2| 1| 4| 1| 3| 6| 4| 6| 6| 4| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    15000 PP                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    M                                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Coronary Artery, Inflammation,       |                                                                          |             
          Chronic                          |                                  2                                       |             
      Endocardium, Thrombosis              | 3                                                                        |             
      Myocardium, Fibrosis                 |                                                                          |             
      Myocardium, Mineralization           |                                                                          |             
      Myocardium, Necrosis                 |                                                                          |             
      Valve, Degeneration, Mucoid          |             2  2        1  2                                             |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Inflammation, Necrotizing   |                                                                          |             
      Subcapsular, Hyperplasia             | 2  2  3  3  2  2  2  2  2  1     2  2  1     2  2  2  2  2  2  2  2  2  3|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                                                          |             
      Congestion                           |                                                                          |             
      Cyst                                 |                                                                          |             
      Degeneration                         |    1     1  2  1     2  2        1  2        1  1  2  2  2  1           2|             
      Fibrosis                             |    1        1  1        1        1  1        1  1  2  1  2              1|             
      Hematopoietic Cell Proliferation     |                                                                   2      |             
      Hemorrhage, Acute                    |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Suppurative            |                            3                                             |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                         3|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  M  M  M  M  +  M  +  M  M  +  M  M  +  M  M  M  M  +  +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                        X                                 |             
      Pars Distalis, Cyst                  |                                                                   2      |             
      Pars Distalis, Hyperplasia           |                1                                                         |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  A  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |       +  +                          +                                    |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |    X              X  X           X           X  2                 X      |             
      Inflammation, Chronic                |                                                                          |             
      Corpus Luteum, Cyst                  |                                                                          |             
      Periovarian Tissue, Inflammation,    |                                                                          |             
           Chronic                         |                         2                                                |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  12                                                               
NTP Experiment-Test: 05078-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 05/05/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:49:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 6| 5| 6| 6| 6| 6| 5| 6| 5| 6| 6| 6| 6| 6| 5| 6| 6| 5| 4| 6| 6| 6|             
                             DAY ON TEST   | 8| 0| 8| 4| 5| 2| 1| 5| 6| 1| 4| 8| 8| 6| 4| 5| 4| 5| 3| 5| 7| 8| 1| 5| 2|             
                                           | 5| 0| 9| 5| 2| 6| 0| 4| 7| 0| 3| 3| 9| 8| 2| 1| 4| 1| 3| 6| 4| 6| 6| 4| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    15000 PP                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    M                                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Necrotizing            |                                                                          |             
      Endometrium, Hyperplasia, Cystic     |                                  2                 2           3         |             
      Endometrium, Inflammation,           |                                                                          |             
          Suppurative                      |                                                                          |             
      Lymphatic, Ectasia                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                2                                                         |             
      Myelofibrosis                        |       1                                         2                        |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  M  +  +  +  +  M  +  +|             
      Sinus, Ectasia                       |                                                                         4|             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  M  +  +  +  A  +  +  +  +  +  +  M  +  +  I  +  M  +  M|             
      Erythrophagocytosis                  |                                              1                           |             
      Hemorrhage                           | 2                                                                        |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Infiltration Cellular, Histiocyte    |                         2                                                |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  M  M  +  A  M  M  +  +  +  M  M  I  +  M  +  M  M  M|             
      Erythrophagocytosis                  |       1                                      2                           |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Subacute               |                            2                                             |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 2  2  2        4     3     3        3  3                             3  2|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  M  M  +  M  M  M  M  +  A  +  +  M  M  +  +  +  M  +  +  +  +  I  M|             
      Cyst                                 |                            X                                             |             
      Infiltration Cellular                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  +  +  M  +  M  +  +  M  +  +  +  +  M  +  +  +  M  +  M  +  +  M  +  +|             
      Inflammation                         |                                                                2         |             
      Duct, Ectasia                        |                                  2           2                 2         |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epidermis, Atrophy                   |                                                             4            |             
      Hair Follicle, Atrophy               | 2  3  1              3  3  3        2  3     3     2     3  4           2|             
      Subcutaneous Tissue, Edema           |                                                                          |             
      Subcutaneous Tissue, Infiltration    |                                                                          |             
          Cellular, Histiocyte             |                                                                         1|             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  13                                                               
NTP Experiment-Test: 05078-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 05/05/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:49:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 6| 5| 6| 6| 6| 6| 5| 6| 5| 6| 6| 6| 6| 6| 5| 6| 6| 5| 4| 6| 6| 6|             
                             DAY ON TEST   | 8| 0| 8| 4| 5| 2| 1| 5| 6| 1| 4| 8| 8| 6| 4| 5| 4| 5| 3| 5| 7| 8| 1| 5| 2|             
                                           | 5| 0| 9| 5| 2| 6| 0| 4| 7| 0| 3| 3| 9| 8| 2| 1| 4| 1| 3| 6| 4| 6| 6| 4| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    15000 PP                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    M                                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |          +                                                     +         |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                | 1                                                                        |             
      Thalamus, Mineralization             |                      1  2              2  2  2  2              2         |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Epithelium, Hyperplasia, Focal       |                                     2                                    |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |             3        4                                      2            |             
      Inflammation, Acute                  |                2  2        2  3                             3        3   |             
      Inflammation, Chronic, Multifocal    |                                                                          |             
      Inflammation, Subacute               |                                                                          |             
      Metaplasia, Osseous                  |                                                                          |             
      Thrombosis                           | 3     X                                                                  |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Diffuse                         |                                                                          |             
      Alveolus, Adenomatosis, Focal        |                            1                                             |             
      Alveolus, Edema                      |                                                                          |             
      Alveolus, Erythrophagocytosis        |             3                                               3            |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |    3        3                                               3            |             
      Bronchiole, Hyperplasia, Multifocal  |                                                                          |             
      Glands, Ectasia                      |                                                       3                  |             
      Interstitium, Inflammation, Chronic  | 2                                                                        |             
      Interstitium, Inflammation, Subacute |                                           2                              |             
      Pleura, Inflammation, Chronic        |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Glands, Dilatation                   |                                                                          |             
      Mucosa, Hyperplasia                  |                                                                          |             
      Mucosa, Inflammation, Suppurative    |                                                       2                  |             
      Nasolacrimal Duct, Hyperplasia       |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                                                                          |             
      Respiratory Epithelium, Hyperplasia  |                                  1                             2         |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |             2                                                  2         |             
      Submucosa, Inflammation, Chronic,    |                                                                          |             
           Diffuse                         |                                                                2         |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  14                                                               
NTP Experiment-Test: 05078-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 05/05/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:49:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 6| 5| 6| 6| 6| 6| 5| 6| 5| 6| 6| 6| 6| 6| 5| 6| 6| 5| 4| 6| 6| 6|             
                             DAY ON TEST   | 8| 0| 8| 4| 5| 2| 1| 5| 6| 1| 4| 8| 8| 6| 4| 5| 4| 5| 3| 5| 7| 8| 1| 5| 2|             
                                           | 5| 0| 9| 5| 2| 6| 0| 4| 7| 0| 3| 3| 9| 8| 2| 1| 4| 1| 3| 6| 4| 6| 6| 4| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    15000 PP                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    M                                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Glands, Dilatation                   |                                                                   2      |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     | +                                                                        |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                       2                  |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hydronephrosis                       |                            3                                3            |             
      Nephropathy                          | 2              3  3  2  3  2           2              2     2            |             
      Glomerulus, Amyloid Deposition       |                                                                          |             
      Renal Tubule, Karyomegaly            |          1  1  1        1                                                |             
      Renal Tubule, Mineralization         |                                                                         3|             
      Renal Tubule, Pigmentation, Bile     |                2                       3                                 |             
                                            __________________________________________________________________________|             
   Ureter                                  |                                                                          |             
      Transitional Epithelium, Necrosis    |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Inflammation, Chronic                | 1     2                                1                                 |             
      Inflammation, Necrotizing            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  15                                                               
NTP Experiment-Test: 05078-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 05/05/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:49:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 6| 5| 6| 5| 5| 6| 6| 6| 6| 7| 5| 6| 5| 5| 5| 6| 6| 6| 3| 5| 4| 5| 5|            |
                             DAY ON TEST   | 9| 5| 2| 5| 6| 3| 7| 6| 1| 0| 5| 0| 7| 6| 9| 7| 3| 1| 2| 3| 2| 8| 6| 8| 9|            |
                                           | 0| 3| 9| 9| 8| 3| 4| 1| 1| 8| 2| 0| 4| 9| 4| 0| 5| 8| 2| 6| 5| 2| 9| 1| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    15000 PP                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    M                                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | A  +  M  +  +  M  A  +  +  +  M  +  +  A  +  M  +  M  M  A  +  +  +  +  +|  32        |
      Inflammation, Suppurative            |                                                                          |      1  3.0|
      Wall, Necrosis                       |          4                                                               |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         | A  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | M  +  +  +  +  A  A  +  +  A  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +|  41        |
      Inflammation, Acute                  |                         2                                                |      1  2.0|
      Inflammation, Necrotizing            |          4                                                               |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | A  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  44        |
      Inflammation, Necrotizing            |          4                                                               |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | A  +  +  A  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | A  +  +  A  +  A  A  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  42        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | A  +  +  A  +  A  A  +  +  A  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  41        |
      Fibrosis                             |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | A  +  +  A  +  A  A  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  42        |
      Atrophy                              |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | A  +  +  A  +  A  A  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  40        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  48        |
      Eosinophilic Focus                   |    1                                                                     |      2  2.0|
      Focal Cellular Change                |    1                                                                     |      2  1.5|
      Hematopoietic Cell Proliferation     |          1                                                     1         |      3  2.0|
      Inclusion Body Intranuclear          |                                                       2                  |      2  2.0|
      Infarct                              |                                                                          |      1  4.0|
      Necrosis                             |                         2              3                                 |      7  2.9|
                                            __________________________________________________________________________|____________|
   Mesentery                               |       +              +  +  +                             +               |  12        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atrophy                              |          3                                                               |      1  3.0|
      Fibrosis                             |                                                                2         |      2  2.0|
      Inflammation, Chronic                |                                                                          |      2  2.0|
      Inflammation, Necrotizing            |          4     4                                                         |      2  4.0|
      Karyomegaly                          |                                        3              2                  |      2  2.5|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Inflammation, Chronic                |                                                                   2      |      3  1.7|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Acanthosis                           |                                                                          |      1  2.0|
      Hemorrhage, Acute                    |                2                                                         |      1  2.0|
      Hyperkeratosis                       |       3                                                        2         |      9  2.2|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|  47        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  16                                                               
NTP Experiment-Test: 05078-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 05/05/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:49:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 6| 5| 6| 5| 5| 6| 6| 6| 6| 7| 5| 6| 5| 5| 5| 6| 6| 6| 3| 5| 4| 5| 5|            |
                             DAY ON TEST   | 9| 5| 2| 5| 6| 3| 7| 6| 1| 0| 5| 0| 7| 6| 9| 7| 3| 1| 2| 3| 2| 8| 6| 8| 9|            |
                                           | 0| 3| 9| 9| 8| 3| 4| 1| 1| 8| 2| 0| 4| 9| 4| 0| 5| 8| 2| 6| 5| 2| 9| 1| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    15000 PP                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    M                                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Metaplasia, Focal, Squamous          |                                              2                           |      1  2.0|
      Necrosis, Coagulative                |                                                                          |      1  2.0|
      Mucosa, Dilatation                   |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Coronary Artery, Inflammation,       |                                                                          |            |
          Chronic                          |                                                                          |      1  2.0|
      Endocardium, Thrombosis              |                                                                          |      1  3.0|
      Myocardium, Fibrosis                 |                               2        1                                 |      2  1.5|
      Myocardium, Mineralization           |                                           2                              |      1  2.0|
      Myocardium, Necrosis                 |                                           3                              |      1  3.0|
      Valve, Degeneration, Mucoid          |                                        2                    1     1      |      7  1.6|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Capsule, Inflammation, Necrotizing   |          4                                                               |      1  4.0|
      Subcapsular, Hyperplasia             | 2  2     3  1  2  2  2  2     2  2  3  2  2     2  2  2  2  3  3  2  2  2|     45  2.1|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Accessory Adrenal Cortical Nodule    |                                                       X                  |      1     |
      Congestion                           |                                        2                                 |      1  2.0|
      Cyst                                 |                               2                                          |      1  2.0|
      Degeneration                         | 2           2           1     1  1  2     2     2     2              2   |     25  1.6|
      Fibrosis                             | 1           2           1     1  1  1     2     2     2                  |     21  1.3|
      Hematopoietic Cell Proliferation     |          2                                                     2         |      3  2.0|
      Hemorrhage, Acute                    |                4                                                         |      1  4.0|
      Inflammation, Chronic                |                                                       2                  |      1  2.0|
      Inflammation, Suppurative            |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  47        |
      Cyst                                 |    3                                                        2            |      2  2.5|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atrophy                              |          3                                            2                  |      3  2.7|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  M  +  M  M  M  M  M  +  M  +  +  +  +  M  +  M  M  +  M  +  M  M  M  M|  19        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  M  +  I  +  +  +  +  +|  45        |
      Cyst                                 |                                                                          |      1     |
      Pars Distalis, Cyst                  |                                                                          |      1  2.0|
      Pars Distalis, Hyperplasia           |       3                                                     2        2   |      4  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  17                                                               
NTP Experiment-Test: 05078-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 05/05/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:49:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 6| 5| 6| 5| 5| 6| 6| 6| 6| 7| 5| 6| 5| 5| 5| 6| 6| 6| 3| 5| 4| 5| 5|            |
                             DAY ON TEST   | 9| 5| 2| 5| 6| 3| 7| 6| 1| 0| 5| 0| 7| 6| 9| 7| 3| 1| 2| 3| 2| 8| 6| 8| 9|            |
                                           | 0| 3| 9| 9| 8| 3| 4| 1| 1| 8| 2| 0| 4| 9| 4| 0| 5| 8| 2| 6| 5| 2| 9| 1| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    15000 PP                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    M                                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 GENERAL BODY SYSTEM - cont                |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                +                                                         |   4        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  48        |
      Cyst                                 |             4                    2  X  X              4                  |     12  3.0|
      Inflammation, Chronic                |          4                                                               |      1  4.0|
      Corpus Luteum, Cyst                  |    X                                                                     |      1     |
      Periovarian Tissue, Inflammation,    |                                                                          |            |
           Chronic                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Necrotizing            |                4                                                         |      1  4.0|
      Endometrium, Hyperplasia, Cystic     |                3        3                                   1            |      6  2.3|
      Endometrium, Inflammation,           |                                                                          |            |
          Suppurative                      |          2                                      3                        |      2  2.5|
      Lymphatic, Ectasia                   |             3                                                            |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                 3                        |      2  2.5|
      Myelofibrosis                        |    2                             2     2           2                     |      6  1.8|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  45        |
      Sinus, Ectasia                       |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | M  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  M|  38        |
      Erythrophagocytosis                  |                                                                          |      1  1.0|
      Hemorrhage                           |                                                                          |      1  2.0|
      Hyperplasia, Lymphoid                |                                           2        2                     |      2  2.0|
      Infiltration Cellular, Histiocyte    |                                     2                                    |      2  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  +  M  +  +  M  +  +  +  M  +  +  +  M  M  +  +  M  +  +  M  M  M  M  M|  26        |
      Erythrophagocytosis                  |                                                                          |      2  1.5|
      Infiltration Cellular, Histiocyte    |    2        1     2                                      1               |      4  1.5|
      Inflammation, Chronic                |                                                       2                  |      1  2.0|
      Inflammation, Subacute               |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hematopoietic Cell Proliferation     |          2  2  3     3              2                 2                 3|     17  2.6|
      Hyperplasia, Lymphoid                |                                  2                                   2   |      2  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  I  +  M  +  M  I  M  +  I  +  M  +  +  +  I  +  +  M  +  +  I  M  M|  25        |
      Cyst                                 |                                                                          |      1     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  18                                                               
NTP Experiment-Test: 05078-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 05/05/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:49:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 6| 5| 6| 5| 5| 6| 6| 6| 6| 7| 5| 6| 5| 5| 5| 6| 6| 6| 3| 5| 4| 5| 5|            |
                             DAY ON TEST   | 9| 5| 2| 5| 6| 3| 7| 6| 1| 0| 5| 0| 7| 6| 9| 7| 3| 1| 2| 3| 2| 8| 6| 8| 9|            |
                                           | 0| 3| 9| 9| 8| 3| 4| 1| 1| 8| 2| 0| 4| 9| 4| 0| 5| 8| 2| 6| 5| 2| 9| 1| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    15000 PP                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    M                                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Infiltration Cellular                |          4                                                               |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +|  38        |
      Inflammation                         |                                                          2               |      2  2.0|
      Duct, Ectasia                        |                                                                          |      3  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Epidermis, Atrophy                   |                                                                          |      1  4.0|
      Hair Follicle, Atrophy               |       3        2  2  2  3                                4               |     19  2.6|
      Subcutaneous Tissue, Edema           |                                                          3               |      1  3.0|
      Subcutaneous Tissue, Infiltration    |                                                                          |            |
          Cellular, Histiocyte             |                                                                          |      1  1.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Chronic                         |                                                          2               |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Thalamus, Mineralization             |    2                                2                             2      |     10  1.9|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Epithelium, Hyperplasia, Focal       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |       2              3                                                   |      5  2.8|
      Inflammation, Acute                  |       2  3                 2  2        2                 3               |     12  2.4|
      Inflammation, Chronic, Multifocal    |                                                                      2   |      1  2.0|
      Inflammation, Subacute               |             3                                                            |      1  3.0|
      Metaplasia, Osseous                  |                                                             1            |      1  1.0|
      Thrombosis                           |                                                                          |      2  3.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Diffuse                         |             3                                                            |      1  3.0|
      Alveolus, Adenomatosis, Focal        |                         2                                                |      2  1.5|
      Alveolus, Edema                      |    3                                                                     |      1  3.0|
      Alveolus, Erythrophagocytosis        |                                                                          |      2  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  19                                                               
NTP Experiment-Test: 05078-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 05/05/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:49:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 6| 5| 6| 5| 5| 6| 6| 6| 6| 7| 5| 6| 5| 5| 5| 6| 6| 6| 3| 5| 4| 5| 5|            |
                             DAY ON TEST   | 9| 5| 2| 5| 6| 3| 7| 6| 1| 0| 5| 0| 7| 6| 9| 7| 3| 1| 2| 3| 2| 8| 6| 8| 9|            |
                                           | 0| 3| 9| 9| 8| 3| 4| 1| 1| 8| 2| 0| 4| 9| 4| 0| 5| 8| 2| 6| 5| 2| 9| 1| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    15000 PP                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    M                                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |       3     3                                         2                  |      6  2.8|
      Bronchiole, Hyperplasia, Multifocal  |                                     2                                    |      1  2.0|
      Glands, Ectasia                      |                                                                          |      1  3.0|
      Interstitium, Inflammation, Chronic  |                                                                          |      1  2.0|
      Interstitium, Inflammation, Subacute |                                                                          |      1  2.0|
      Pleura, Inflammation, Chronic        |                                                                      2   |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Glands, Dilatation                   |       2                                                  3               |      2  2.5|
      Mucosa, Hyperplasia                  | 2                                                                        |      1  2.0|
      Mucosa, Inflammation, Suppurative    |                                                                          |      1  2.0|
      Nasolacrimal Duct, Hyperplasia       | 2                                                                        |      1  2.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |                                                    2                     |      1  2.0|
      Respiratory Epithelium, Hyperplasia  |                                                                          |      2  1.5|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        |                                                                          |      2  2.0|
      Submucosa, Inflammation, Chronic,    |                                                                          |            |
           Diffuse                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Glands, Dilatation                   |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +                                                                    +   |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Cyst                                 |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |          2                                                               |      1  2.0|
      Hydronephrosis                       |    3                          2           2        2                     |      6  2.5|
      Nephropathy                          | 3  3  3                       2  2  2     2        2  2  2              3|     20  2.4|
      Glomerulus, Amyloid Deposition       |                                                                      3   |      1  3.0|
      Renal Tubule, Karyomegaly            |                                                                   1      |      5  1.0|
      Renal Tubule, Mineralization         |                                                                          |      1  3.0|
      Renal Tubule, Pigmentation, Bile     |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Ureter                                  |                +                                      +                  |   2        |
      Transitional Epithelium, Necrosis    |                                                       4                  |      1  4.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  A  M  +  M  +  +  +  A  +  +  +  +  +  A  +  +  +  +  +|  43        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  20                                                               
NTP Experiment-Test: 05078-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 05/05/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:49:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 6| 5| 6| 5| 5| 6| 6| 6| 6| 7| 5| 6| 5| 5| 5| 6| 6| 6| 3| 5| 4| 5| 5|            |
                             DAY ON TEST   | 9| 5| 2| 5| 6| 3| 7| 6| 1| 0| 5| 0| 7| 6| 9| 7| 3| 1| 2| 3| 2| 8| 6| 8| 9|            |
                                           | 0| 3| 9| 9| 8| 3| 4| 1| 1| 8| 2| 0| 4| 9| 4| 0| 5| 8| 2| 6| 5| 2| 9| 1| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    15000 PP                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    M                                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Edema                                |                               4                                          |      1  4.0|
      Inflammation, Chronic                |    2  1                                                                  |      5  1.4|
      Inflammation, Necrotizing            |                3                                                         |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  21                                                               
NTP Experiment-Test: 05078-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 05/05/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:49:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 6| 7| 7| 7| 6| 6| 5| 6| 7| 6| 5| 7| 7| 5| 7| 7| 4| 7| 4| 7| 7|             
                             DAY ON TEST   | 0| 0| 0| 7| 4| 0| 0| 0| 5| 2| 1| 5| 0| 1| 8| 0| 0| 2| 0| 0| 0| 0| 8| 0| 0|             
                                           | 0| 0| 0| 9| 6| 0| 0| 0| 4| 9| 6| 8| 0| 0| 7| 0| 0| 4| 0| 0| 9| 0| 6| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  M  +  +  +  +  +  A  +  +  +  M  +  +  +  M  +  M  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  M  M  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  M  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                          2               |             
      Infiltration Cellular, Focal,        |                                                                          |             
          Histiocyte                       |    3                                                                     |             
      Necrosis                             |                         4                                                |             
      Hepatocyte, Cytomegaly               |             3                                                            |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                | 1     2                 2                             2                  |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                                                   2      |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                         2|             
      Cyst                                 |                                                                   2      |             
      Hyperplasia                          |                                                                   2      |             
      Metaplasia, Squamous                 |                                                             1            |             
      Mucosa, Necrosis                     |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |       +                                                                  |             
      Abscess                              |       2                                                                  |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Coronary Artery, Inflammation,       |                                                                          |             
          Chronic                          |    3           2                                                         |             
      Coronary Artery, Mineralization      |                2                                                         |             
      Valve, Degeneration, Mucoid          |       1  2     2                          2                       2      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  I  +  A  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +|             
      Capsule, Inflammation, Necrotizing   |                                                                          |             
      Subcapsular, Hyperplasia             | 1  1     2  1  2  2              1        2  1  1        1  1     2      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +     I  +  A  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  22                                                               
NTP Experiment-Test: 05078-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 05/05/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:49:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 6| 7| 7| 7| 6| 6| 5| 6| 7| 6| 5| 7| 7| 5| 7| 7| 4| 7| 4| 7| 7|             
                             DAY ON TEST   | 0| 0| 0| 7| 4| 0| 0| 0| 5| 2| 1| 5| 0| 1| 8| 0| 0| 2| 0| 0| 0| 0| 8| 0| 0|             
                                           | 0| 0| 0| 9| 6| 0| 0| 0| 4| 9| 6| 8| 0| 0| 7| 0| 0| 4| 0| 0| 9| 0| 6| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Focal                   |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  I  +  A  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  M  M  +  +  +  M  I  M  +  +  M  M  +  +  M  +  +  M  M  M  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +|             
      Pars Distalis, Hyperplasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                +         |             
      Hemorrhage, Focal                    |                                                                3         |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | M  +  M  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Inflammation, Necrotizing            |                                                                          |             
                                            __________________________________________________________________________|             
   Penis                                   |                +        +                          +                     |             
      Inflammation, Suppurative            |                                                    4                     |             
      Necrosis                             |                4        3                                                |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |    +           +     +        +  +           +                    +  +  +|             
      Abscess                              |                      4           4                                       |             
      Cyst                                 |                X              3              4                       3  3|             
      Inflammation, Chronic                |                                              4                           |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Suppurative            |                                                    4                     |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  A  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                4                                                         |             
      Inflammation, Necrotizing            |                                                                          |             
      Inflammation, Suppurative            |                                                    4                     |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                     2           2              3         |             
      Vein, Angiectasis                    |                                  2                                       |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  M  M  +  +  +  +  I  M  +  +  +  M  +  +  +  +  +  +  M  +  M  I|             
      Infiltration Cellular, Histiocyte    |                                                 1                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  M  M  M  +  +  +  M  M  M  +  +  M  +  +  +  +  M  +  M  +  M  I|             
      Infiltration Cellular, Histiocyte    |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  M  M  +  +  I  M  I  M  +  +  M  M  M  +  M  M  +  M  M  M  M  M|             
      Ectasia                              |                                                                          |             
      Infiltration Cellular, Histiocyte    |                   1                                      1               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  23                                                               
NTP Experiment-Test: 05078-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 05/05/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:49:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 6| 7| 7| 7| 6| 6| 5| 6| 7| 6| 5| 7| 7| 5| 7| 7| 4| 7| 4| 7| 7|             
                             DAY ON TEST   | 0| 0| 0| 7| 4| 0| 0| 0| 5| 2| 1| 5| 0| 1| 8| 0| 0| 2| 0| 0| 0| 0| 8| 0| 0|             
                                           | 0| 0| 0| 9| 6| 0| 0| 0| 4| 9| 6| 8| 0| 0| 7| 0| 0| 4| 0| 0| 9| 0| 6| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |    1                                                                     |             
      Fibrosis                             |       3                                                                  |             
      Hematopoietic Cell Proliferation     |             1           2        2     3                                 |             
      Hemorrhage, Chronic                  |       3                                                                  |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                       2  3               |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +  M  M  +  +  +  I  M  +  M  +  M  +  +  +  +  +  +  M  +  M  +  M|             
      Necrosis, Multiple                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  M  M  M  M  +  +  +  +  M  M  M  +  M  +  M  +  M  M  +  +  M  M  M  M|             
      Inflammation, Chronic                |                                           3                              |             
      Duct, Ectasia                        |                                           3                              |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hair Follicle, Atrophy               |                2        3                                      3        2|             
      Hair Follicle, Degeneration          |                                                                3         |             
      Hair Follicle, Ectasia               |                                                                3         |             
      Prepuce, Abscess                     |                                  4                                       |             
      Prepuce, Inflammation, Necrotizing   |                                                    4                     |             
      Prepuce, Inflammation, Suppurative   |                                                                          |             
      Prepuce, Ulcer                       |             4  4        4              4                    4     3      |             
      Subcutaneous Tissue, Hyperplasia,    |                                                                          |             
           Lymphoid                        |                      4                                                   |             
      Subcutaneous Tissue, Infiltration    |                                                                          |             
          Cellular, Histiocyte             |                            2                                             |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic                         |                                           3                              |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Suppurative                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                           +                              |             
      Inflammation, Necrotizing            |                                           4                              |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |          2                                                               |             
      Thalamus, Mineralization             |    2                 2  2  2        2  2     2  2  2        2  2  2     2|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  24                                                               
NTP Experiment-Test: 05078-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 05/05/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:49:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 6| 7| 7| 7| 6| 6| 5| 6| 7| 6| 5| 7| 7| 5| 7| 7| 4| 7| 4| 7| 7|             
                             DAY ON TEST   | 0| 0| 0| 7| 4| 0| 0| 0| 5| 2| 1| 5| 0| 1| 8| 0| 0| 2| 0| 0| 0| 0| 8| 0| 0|             
                                           | 0| 0| 0| 9| 6| 0| 0| 0| 4| 9| 6| 8| 0| 0| 7| 0| 0| 4| 0| 0| 9| 0| 6| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Dilatation                           |                                                                          |             
      Submucosa, Inflammation, Chronic     |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bronchiectasis                       |                                                                          |             
      Hemorrhage                           |          2                                                               |             
      Hyperplasia, Lymphoid                | 1                                                                        |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic, Multifocal    |                         2                                2     2         |             
      Inflammation, Chronic Active         |                                           4                              |             
      Alveolus, Adenomatosis, Focal        |                                                                          |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                                                                          |             
      Glands, Ectasia                      |       2        2                                            2            |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Glands, Cyst                         |                                                                          |             
      Glands, Hyperplasia                  |                                                                      2   |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |       2                                                                  |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |       +                                                                  |             
      Cornea, Inflammation, Subacute       |       2                                                                  |             
      Cornea, Necrosis, Focal              |       2                                                                  |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |       +                                                  +               |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Suppurative            |                               4        4                                 |             
      Nephropathy                          | 1  1  2        1  1  1  1        3  1        1        1  1  1  3  2     2|             
      Capsule, Inflammation, Necrotizing   |                                                                          |             
      Pelvis, Inflammation, Suppurative    |                                                    3              3      |             
                                            __________________________________________________________________________|             
   Ureter                                  |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                        4                                 |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Suppurative            |                                                    4              3      |             
      Transitional Epithelium, Hyperplasia |                                                                   3      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  25                                                               
NTP Experiment-Test: 05078-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 05/05/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:49:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 6| 7| 7| 7| 7| 4| 0| 4| 7| 7| 7| 5| 7| 7| 7| 6| 7| 5| 7| 5| 5| 5|            |
                             DAY ON TEST   | 6| 0| 0| 6| 0| 0| 0| 0| 1| 1| 0| 0| 0| 0| 7| 0| 0| 0| 8| 0| 2| 0| 2| 6| 7|            |
                                           | 0| 0| 0| 8| 0| 0| 0| 0| 3| 7| 9| 0| 0| 0| 8| 0| 0| 0| 2| 0| 6| 0| 6| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  M  +  +  +  I  M  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +|  40        |
      Inflammation, Chronic                |                                                       2                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  M  +  +  +  +  +  M  +  +  +  +  A  +  +  +  M  +  M  +  +  +  +|  41        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  M  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  M  +  +  +  +  +  +  +  M  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  M  +  +  +  +  +  +  +  M  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hematopoietic Cell Proliferation     |                                                       1                  |      2  1.5|
      Infiltration Cellular, Focal,        |                                                                          |            |
          Histiocyte                       |                                                                          |      1  3.0|
      Necrosis                             | 3                                                                        |      2  3.5|
      Hepatocyte, Cytomegaly               |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Chronic                |          2  2                                      2                     |      7  1.9|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperkeratosis                       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atrophy                              |                                                                          |      1  2.0|
      Cyst                                 |                                                                          |      1  2.0|
      Hyperplasia                          |                                                                          |      1  2.0|
      Metaplasia, Squamous                 |                                                                          |      1  1.0|
      Mucosa, Necrosis                     |          2                                                               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                           +                              |   2        |
      Abscess                              |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Coronary Artery, Inflammation,       |                                                                          |            |
          Chronic                          |                                                                          |      2  2.5|
      Coronary Artery, Mineralization      |                                                                          |      1  2.0|
      Valve, Degeneration, Mucoid          |                         2                             2                  |      7  1.9|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  26                                                               
NTP Experiment-Test: 05078-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 05/05/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:49:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 6| 7| 7| 7| 7| 4| 0| 4| 7| 7| 7| 5| 7| 7| 7| 6| 7| 5| 7| 5| 5| 5|            |
                             DAY ON TEST   | 6| 0| 0| 6| 0| 0| 0| 0| 1| 1| 0| 0| 0| 0| 7| 0| 0| 0| 8| 0| 2| 0| 2| 6| 7|            |
                                           | 0| 0| 0| 8| 0| 0| 0| 0| 3| 7| 9| 0| 0| 0| 8| 0| 0| 0| 2| 0| 6| 0| 6| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Capsule, Inflammation, Necrotizing   |                                                       4                  |      1  4.0|
      Subcapsular, Hyperplasia             |    2     1              2     1  2           2           1     2  2  2   |     23  1.5|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Hyperplasia, Focal                   |                                                 3                        |      1  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  M  I  M  +  M  +  +  +  M  M  M  +  M  M  +  M  M  M  +  +  +  M  M  M|  21        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +|  47        |
      Pars Distalis, Hyperplasia           |             2                                                            |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cyst                                 |                                              2                           |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
      Hemorrhage, Focal                    |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Inflammation, Necrotizing            |                                                       4                  |      1  4.0|
                                            __________________________________________________________________________|____________|
   Penis                                   |                                                                          |   3        |
      Inflammation, Suppurative            |                                                                          |      1  4.0|
      Necrosis                             |                                                                          |      2  3.5|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +     +  +           +           +                          +  +  +  +|  19        |
      Abscess                              |    4                                                                     |      3  4.0|
      Cyst                                 |                         3                                                |      6  3.2|
      Inflammation, Chronic                |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Chronic                |                                                             2            |      1  2.0|
      Inflammation, Suppurative            |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +|  46        |
      Dilatation                           |                         3                                         2      |      3  3.0|
      Inflammation, Necrotizing            |                                                       4                  |      1  4.0|
      Inflammation, Suppurative            |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Atrophy                              |                                                                         1|      4  2.0|
      Vein, Angiectasis                    |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  27                                                               
NTP Experiment-Test: 05078-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 05/05/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:49:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 6| 7| 7| 7| 7| 4| 0| 4| 7| 7| 7| 5| 7| 7| 7| 6| 7| 5| 7| 5| 5| 5|            |
                             DAY ON TEST   | 6| 0| 0| 6| 0| 0| 0| 0| 1| 1| 0| 0| 0| 0| 7| 0| 0| 0| 8| 0| 2| 0| 2| 6| 7|            |
                                           | 0| 0| 0| 8| 0| 0| 0| 0| 3| 7| 9| 0| 0| 0| 8| 0| 0| 0| 2| 0| 6| 0| 6| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  M  +  +  I  I  +  +  +  +  I  +  +  +  +  +  +|  38        |
      Infiltration Cellular, Histiocyte    |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  M  +  +  I  M  M  +  M  +  M  I  I  +  +  +  I  I  +  +  +  +  +  +|  29        |
      Infiltration Cellular, Histiocyte    |          2                                                               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  M  +  M  M  +  +  +  +  M  +  +  M  I  M  M  M  +  I  I  M  +  M  M  M|  19        |
      Ectasia                              |                                  3                                       |      1  3.0|
      Infiltration Cellular, Histiocyte    |                      2           2                                       |      4  1.5|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atrophy                              |                                                                          |      1  1.0|
      Fibrosis                             |                                                                          |      1  3.0|
      Hematopoietic Cell Proliferation     |          2                                            2                  |      6  2.0|
      Hemorrhage, Chronic                  |                                                                          |      1  3.0|
      Hemorrhage                           |                                                             3            |      1  3.0|
      Hyperplasia, Lymphoid                |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  +  +  +  +  +  +  +  +  +  M  +  I  +  I  +  M  +  M  +  M  +  +  +  +|  33        |
      Necrosis, Multiple                   |                            2                                             |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  M  M  M  M  M  M  M  M  M  M  M  M  M  +  M  M  +  M  M  +  +  +  +|  18        |
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Duct, Ectasia                        |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hair Follicle, Atrophy               | 2     3     3                    2     2                 3     2         |     11  2.5|
      Hair Follicle, Degeneration          |                                                                          |      1  3.0|
      Hair Follicle, Ectasia               |                                                                          |      1  3.0|
      Prepuce, Abscess                     |                         3                                               3|      3  3.3|
      Prepuce, Inflammation, Necrotizing   |                                                                          |      1  4.0|
      Prepuce, Inflammation, Suppurative   | 3                                                                        |      1  3.0|
      Prepuce, Ulcer                       |    3     3                                                        3  3   |     10  3.5|
      Subcutaneous Tissue, Hyperplasia,    |                                                                          |            |
           Lymphoid                        |                                                                          |      1  4.0|
      Subcutaneous Tissue, Infiltration    |                                                                          |            |
          Cellular, Histiocyte             |                                                                          |      1  2.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Chronic                         |                                                                          |      1  3.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  28                                                               
NTP Experiment-Test: 05078-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 05/05/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:49:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 6| 7| 7| 7| 7| 4| 0| 4| 7| 7| 7| 5| 7| 7| 7| 6| 7| 5| 7| 5| 5| 5|            |
                             DAY ON TEST   | 6| 0| 0| 6| 0| 0| 0| 0| 1| 1| 0| 0| 0| 0| 7| 0| 0| 0| 8| 0| 2| 0| 2| 6| 7|            |
                                           | 0| 0| 0| 8| 0| 0| 0| 0| 3| 7| 9| 0| 0| 0| 8| 0| 0| 0| 2| 0| 6| 0| 6| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
           Suppurative                     |                                                                         2|      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                      +                                                   |   2        |
      Inflammation, Necrotizing            |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Focal,        |                                                                          |            |
          Lymphocyte                       |                                                                          |      1  2.0|
      Thalamus, Mineralization             |          2     2              2                    2     2              2|     19  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Dilatation                           |          3                                                               |      1  3.0|
      Submucosa, Inflammation, Chronic     |                                  2                                       |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Bronchiectasis                       |                      3                                                   |      1  3.0|
      Hemorrhage                           |                                                                          |      1  2.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  1.0|
      Inflammation, Acute                  |          2                                                               |      1  2.0|
      Inflammation, Chronic, Multifocal    |    2                                   2        2  2  2  2               |      9  2.0|
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
      Alveolus, Adenomatosis, Focal        |                         2                                                |      1  2.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                                                 2                        |      1  2.0|
      Glands, Ectasia                      |                                                                          |      3  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Glands, Cyst                         |                2                             2                           |      2  2.0|
      Glands, Hyperplasia                  |                                                                          |      1  2.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                  +                                       |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                            +                                             |   2        |
      Cornea, Inflammation, Subacute       |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  29                                                               
NTP Experiment-Test: 05078-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 05/05/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:49:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 6| 7| 7| 7| 7| 4| 0| 4| 7| 7| 7| 5| 7| 7| 7| 6| 7| 5| 7| 5| 5| 5|            |
                             DAY ON TEST   | 6| 0| 0| 6| 0| 0| 0| 0| 1| 1| 0| 0| 0| 0| 7| 0| 0| 0| 8| 0| 2| 0| 2| 6| 7|            |
                                           | 0| 0| 0| 8| 0| 0| 0| 0| 3| 7| 9| 0| 0| 0| 8| 0| 0| 0| 2| 0| 6| 0| 6| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Cornea, Necrosis, Focal              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |             +                 +           +                              |   5        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                      2                                                   |      1  2.0|
      Inflammation, Chronic                |    2                                                                     |      1  2.0|
      Inflammation, Suppurative            |                                                                          |      2  4.0|
      Nephropathy                          |       1        1     2           1  2           2     2  1  1  1     1   |     27  1.4|
      Capsule, Inflammation, Necrotizing   |                                                       4                  |      1  4.0|
      Pelvis, Inflammation, Suppurative    |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Ureter                                  |                                           +                              |   1        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Inflammation, Acute                  |                                                                          |      1  4.0|
      Inflammation, Chronic                |                                                          1  2            |      2  1.5|
      Inflammation, Suppurative            |                                                                          |      2  3.5|
      Transitional Epithelium, Hyperplasia |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  30                                                               
NTP Experiment-Test: 05078-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 05/05/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:49:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 3| 5| 5| 5| 3| 4| 3| 2| 2| 2| 2| 3| 7| 4| 3| 6| 3| 7| 6| 5|             
                             DAY ON TEST   | 0| 0| 0| 0| 0| 0| 2| 9| 0| 6| 0| 9| 7| 6| 5| 6| 6| 0| 8| 6| 3| 5| 0| 7| 7|             
                                           | 0| 0| 0| 0| 0| 8| 6| 6| 7| 0| 9| 8| 8| 1| 7| 9| 0| 0| 6| 0| 8| 7| 0| 1| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    15000 PP                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    M                                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                                                          |             
                                            __________________________________________________________________________|             
   Gallbladder                             | M  M  M  I  M  M  +  +  +  +  +  +  +  +  A  +  M  +  M  M  A  A  M  +  +|             
      Mucosa, Hyperplasia                  |                                  2                                       |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  A  +  +  +  +|             
      Anus, Necrosis, Focal                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  M  A  A  +  +  +  +  +  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  M  A  A  +  +  +  +  +  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  M  A  A  +  +  +  +  +  A  +  +  +  +|             
      Ulcer                                |             3                                                            |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  M  A  A  +  +  +  +  +  A  +  +  +  +|             
      Inflammation, Subacute               |                                                    3                     |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  M  A  A  +  +  +  +  +  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                                          |             
      Hematopoietic Cell Proliferation     | 1                                                                    2   |             
      Inflammation, Acute                  |                                                                      2   |             
      Mineralization, Focal                |                                        1                                 |             
      Necrosis                             |          4  4                    3                                       |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                        +     +                           |             
      Inflammation, Suppurative            |                                              3                           |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                  2                       2               |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                 2        2               |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                   2                                                      |             
      Epithelium, Hyperplasia              |                   2                                   2                  |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |          X                                                               |             
      Inflammation, Chronic                |                                                                          |             
      Metaplasia, Squamous                 |                               2                          1               |             
      Mineralization                       |                                                 1                        |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Valve, Degeneration                  |                               2  2                                       |             
      Valve, Degeneration, Mucoid          |          1  1                                   1        2     1         |             
      Valve, Mineralization                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  31                                                               
NTP Experiment-Test: 05078-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 05/05/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:49:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 3| 5| 5| 5| 3| 4| 3| 2| 2| 2| 2| 3| 7| 4| 3| 6| 3| 7| 6| 5|             
                             DAY ON TEST   | 0| 0| 0| 0| 0| 0| 2| 9| 0| 6| 0| 9| 7| 6| 5| 6| 6| 0| 8| 6| 3| 5| 0| 7| 7|             
                                           | 0| 0| 0| 0| 0| 8| 6| 6| 7| 0| 9| 8| 8| 1| 7| 9| 0| 0| 6| 0| 8| 7| 0| 1| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    15000 PP                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    M                                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  M  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Subcapsular, Hyperplasia             |       2  2  1  2     2  2  1                 2  2     2  1  2     2  1   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  M  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Focal                  |                                                                   2      |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia, Focal                   |                                        2                          2      |             
      Hypertrophy, Focal                   |                                                    2                     |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  +  M  M  M  M  M  M  M  M  +  +  M  M  +  M  M  +  M  +  M  M  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  I  +  +  +  +  +  +  +  +  +  +  +  M  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |    +                             +                                       |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  M  M  +  M  +  +  +  +  +  +  +  +  +  A  +  +  +     +  +  +  M     +|             
                                            __________________________________________________________________________|             
   Penis                                   | +                       +                    +                       +   |             
      Inflammation, Suppurative            |                                                                      4   |             
      Necrosis                             | 4                       2                    4                       4   |             
      Endothelium, Hyperplasia,            |                                                                          |             
          Pseudoepitheliomatous            |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                   +        +                       +  +  +  +  +     +  +|             
      Abscess                              |                                                                          |             
      Cyst                                 |                            X                       1  4  X     X         |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Necrotizing            |                                                                         4|             
      Inflammation, Suppurative            |                                                       4                  |             
                                            __________________________________________________________________________|             
   Prostate                                | I  +  +  +  +  M  +  +  +  +  +  M  +  +  A  +  +  +  +  +  A  +  +  +  M|             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Suppurative            |                                     3                                    |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  M   |             
      Dilatation                           | 4                                         3  2           2               |             
      Inflammation, Chronic                |                                     2                                    |             
      Inflammation, Suppurative            |                3                                                         |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 2  3     2  2                                                     2  2   |             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  32                                                               
NTP Experiment-Test: 05078-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 05/05/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:49:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 3| 5| 5| 5| 3| 4| 3| 2| 2| 2| 2| 3| 7| 4| 3| 6| 3| 7| 6| 5|             
                             DAY ON TEST   | 0| 0| 0| 0| 0| 0| 2| 9| 0| 6| 0| 9| 7| 6| 5| 6| 6| 0| 8| 6| 3| 5| 0| 7| 7|             
                                           | 0| 0| 0| 0| 0| 8| 6| 6| 7| 0| 9| 8| 8| 1| 7| 9| 0| 0| 6| 0| 8| 7| 0| 1| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    15000 PP                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    M                                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  M  M  M  +  M  M  +|             
      Mediastinal, Sinus, Infiltration     |                                                                          |             
          Cellular                         |                                  2                                       |             
      Mesenteric, Infiltration Cellular,   |                                                                          |             
           Histiocyte                      |                                           2                              |             
      Renal, Inflammation, Acute           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  M  M  M  M  M  M  +|             
      Infiltration Cellular, Histiocyte    |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  M  M  M  +  M  +  +  +  +  +  M  M  M  A  M  M  +  M  M  M  +  M  M  M|             
      Erythrophagocytosis                  | 2                                                                        |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia                          |                   3                                                      |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                    3                     |             
      Congestion, Acute                    |                                                                          |             
      Hematopoietic Cell Proliferation     |          2                                   2  2                    2   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  I  M  +  M  +  +  M  +  M  M  M  +  A  +  +  +  +  +  A  +  +  +  +|             
      Cyst                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  +  M  M  M     M  M  M  M  M  M  M  M  M  M  +  M  M  M  +  +  M  +|             
                                            __________________________________________________________________________|             
   Mammary Gland, Mandibular               |                   +                                                      |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                   3                                                      |             
      Hair Follicle, Atrophy               |       3  2                                                               |             
      Prepuce, Cyst                        | X                                                                        |             
      Prepuce, Hyperkeratosis              |                      4                                                   |             
      Prepuce, Inflammation, Chronic       |                            1                             2               |             
      Prepuce, Inflammation, Necrotizing   |                                                                         4|             
      Prepuce, Inflammation, Suppurative   |                                                       4                  |             
      Prepuce, Ulcer                       |                   2  3  3                    3              3  4     4   |             
      Subcutaneous Tissue, Hyperplasia,    |                                                                          |             
           Lymphoid                        |                                                                3         |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Acute                           |                                                                          |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic                         |                                                                          |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Suppurative                     |                                        2                                 |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  33                                                               
NTP Experiment-Test: 05078-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 05/05/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:49:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 3| 5| 5| 5| 3| 4| 3| 2| 2| 2| 2| 3| 7| 4| 3| 6| 3| 7| 6| 5|             
                             DAY ON TEST   | 0| 0| 0| 0| 0| 0| 2| 9| 0| 6| 0| 9| 7| 6| 5| 6| 6| 0| 8| 6| 3| 5| 0| 7| 7|             
                                           | 0| 0| 0| 0| 0| 8| 6| 6| 7| 0| 9| 8| 8| 1| 7| 9| 0| 0| 6| 0| 8| 7| 0| 1| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    15000 PP                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    M                                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
      Thalamus, Mineralization             |    2        2     2  2  2  2                             2  2            |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                +                                                         |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Submucosa, Cyst                      |       X                                                                  |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                 2                        |             
      Inflammation, Acute                  |                                                                         3|             
      Inflammation, Chronic, Multifocal    |                                                                          |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                     2                                    |             
      Bronchiole, Hyperplasia, Multifocal  |          2                                                               |             
      Glands, Ectasia                      |       2                                                                  |             
      Interstitium, Inflammation, Chronic  |       2                                                                  |             
      Submucosa, Bronchus, Glands, Ectasia |                         2                                                |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Glands, Cyst                         |          X                                                               |             
      Olfactory Epithelium, Hyperplasia    |                                  2                                       |             
      Septum, Developmental Malformation   |                                                                   X      |             
      Submucosa, Inflammation, Chronic     |                                                 1                        |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Glands, Dilatation                   |                                                    1                     |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                  +                    +                  |             
                                            __________________________________________________________________________|             
   Eye                                     |             +                                      +                     |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |             +                                      +                     |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydronephrosis                       |                                                                         1|             
      Infarct                              |                                     3     3                              |             
      Inflammation, Chronic                |                            1                    2                        |             
      Inflammation, Suppurative            |                4                 4  3     2                              |             
      Necrosis                             |                                  4        2                              |             
      Nephropathy                          | 1  1  2  1  4     1     1                    1     1  2           2  1   |             
      Pelvis, Inflammation, Suppurative    |                                                                          |             
      Renal Tubule, Karyomegaly            | 2  2  1  1        1  1  1  2  2  2     2     2  2  1  2  2     1  1  1  2|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  34                                                               
NTP Experiment-Test: 05078-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 05/05/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:49:45  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 3| 5| 5| 5| 3| 4| 3| 2| 2| 2| 2| 3| 7| 4| 3| 6| 3| 7| 6| 5|             
                             DAY ON TEST   | 0| 0| 0| 0| 0| 0| 2| 9| 0| 6| 0| 9| 7| 6| 5| 6| 6| 0| 8| 6| 3| 5| 0| 7| 7|             
                                           | 0| 0| 0| 0| 0| 8| 6| 6| 7| 0| 9| 8| 8| 1| 7| 9| 0| 0| 6| 0| 8| 7| 0| 1| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    15000 PP                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    M                                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Renal Tubule, Mineralization         |                                        1                                 |             
                                            __________________________________________________________________________|             
   Ureter                                  |                                                                          |             
      Mucosa, Inflammation, Chronic        |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +  +|             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Necrotizing            |                                  4                                       |             
      Inflammation, Suppurative            |                3                             2                           |             
      Lumen, Concretion                    |                                                                         2|             
      Transitional Epithelium, Hyperplasia |                                                          1               |             
      Transitional Epithelium, Necrosis    |                4        1        4                                      2|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  35                                                               
NTP Experiment-Test: 05078-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 05/05/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:49:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 3| 7| 3| 7| 4| 3| 7| 5| 7| 5| 5| 6| 5| 2| 3| 4| 6| 5| 4| 5| 3| 4| 5| 4|            |
                             DAY ON TEST   | 9| 2| 0| 5| 0| 6| 6| 0| 2| 0| 2| 8| 1| 0| 2| 6| 0| 7| 5| 3| 1| 3| 4| 2| 0|            |
                                           | 4| 9| 0| 8| 0| 5| 3| 0| 6| 0| 6| 7| 0| 2| 6| 3| 9| 3| 9| 4| 9| 0| 8| 4| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    15000 PP                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    M                                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  48        |
      Hyperkeratosis                       |                                                             3            |      1  3.0|
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  M  +  M  +  +  +  +  +  +  +  A  +  M  +  +  A  +  +  +  M  +  +  +|  31        |
      Mucosa, Hyperplasia                  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +  +|  45        |
      Anus, Necrosis, Focal                |                                                                2         |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  M  +  A  +  +  +  +  +  A  +  +  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  A  +  +  +  +|  43        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  M  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  A  +  +  +  +|  42        |
      Ulcer                                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  A  +  +  +  +|  43        |
      Inflammation, Subacute               |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  A  +  +  +  +|  43        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  47        |
      Basophilic Focus                     |          2                                                               |      1  2.0|
      Hematopoietic Cell Proliferation     |                                                                      2   |      3  1.7|
      Inflammation, Acute                  |                                                                          |      1  2.0|
      Mineralization, Focal                |                                                                          |      1  1.0|
      Necrosis                             | 1                          3                                             |      5  3.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                           A     +                        |   3        |
      Inflammation, Suppurative            |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  47        |
      Hyperplasia                          |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  48        |
      Inflammation, Chronic                |          2  2     2     2     2                                          |      7  2.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  48        |
      Hyperkeratosis                       |                                                             2            |      2  2.0|
      Epithelium, Hyperplasia              |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  48        |
      Cyst                                 |                                                                          |      1     |
      Inflammation, Chronic                |          2                                                               |      1  2.0|
      Metaplasia, Squamous                 |                                        2        2                        |      4  1.8|
      Mineralization                       |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  48        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  36                                                               
NTP Experiment-Test: 05078-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 05/05/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:49:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 3| 7| 3| 7| 4| 3| 7| 5| 7| 5| 5| 6| 5| 2| 3| 4| 6| 5| 4| 5| 3| 4| 5| 4|            |
                             DAY ON TEST   | 9| 2| 0| 5| 0| 6| 6| 0| 2| 0| 2| 8| 1| 0| 2| 6| 0| 7| 5| 3| 1| 3| 4| 2| 0|            |
                                           | 4| 9| 0| 8| 0| 5| 3| 0| 6| 0| 6| 7| 0| 2| 6| 3| 9| 3| 9| 4| 9| 0| 8| 4| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    15000 PP                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    M                                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Valve, Degeneration                  |                                                                          |      2  2.0|
      Valve, Degeneration, Mucoid          |                                              2           2     2         |      8  1.5|
      Valve, Mineralization                |                      1                                                   |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  47        |
      Subcapsular, Hyperplasia             |    2     2     2  2     2     2              2  1     1  1     1  1  2   |     27  1.7|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  M  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  46        |
      Degeneration, Focal                  |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |                                     3                                    |      1  3.0|
      Hyperplasia, Focal                   |                                                                          |      2  2.0|
      Hypertrophy, Focal                   |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  47        |
      Cyst                                 |                                                          3               |      1  3.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  48        |
      Atrophy                              |                                                    4                     |      1  4.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  +  M  M  +  +  M  M  M  +  +  M  M  M  M  M  M  +  M  +  M  M  M  M|  17        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  M  A  +  +  A  +  +  +  +  +  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  48        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                      +   |   3        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  M  M  +  +  +  +  +  +     +  A  +  +  +  +  +  +  +  +  +  +|  39        |
                                            __________________________________________________________________________|____________|
   Penis                                   |                   +              +     +                                +|   8        |
      Inflammation, Suppurative            |                   2                                                      |      2  3.0|
      Necrosis                             |                                        2                                2|      6  3.0|
      Endothelium, Hyperplasia,            |                                                                          |            |
          Pseudoepitheliomatous            |                                  3                                       |      1  3.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |    +     +     +  +     +  +  +  +           +        +  +  +     +  +  +|  24        |
      Abscess                              |          3                                                               |      1  3.0|
      Cyst                                 |          X                    2  4           3              2     3      |     11  2.7|
      Hyperplasia                          |          2                                                        3      |      2  2.5|
      Inflammation, Chronic                |          2                    2                             4     2      |      4  2.5|
      Inflammation, Necrotizing            |                4           4                                             |      3  4.0|
      Inflammation, Suppurative            |    2              3     4                                               3|      5  3.2|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  43        |
      Inflammation, Chronic                |                                        3     3                           |      2  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  37                                                               
NTP Experiment-Test: 05078-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 05/05/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:49:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 3| 7| 3| 7| 4| 3| 7| 5| 7| 5| 5| 6| 5| 2| 3| 4| 6| 5| 4| 5| 3| 4| 5| 4|            |
                             DAY ON TEST   | 9| 2| 0| 5| 0| 6| 6| 0| 2| 0| 2| 8| 1| 0| 2| 6| 0| 7| 5| 3| 1| 3| 4| 2| 0|            |
                                           | 4| 9| 0| 8| 0| 5| 3| 0| 6| 0| 6| 7| 0| 2| 6| 3| 9| 3| 9| 4| 9| 0| 8| 4| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    15000 PP                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    M                                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Suppurative            |                                                                      2   |      2  2.5|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +     +  +     +  +  +  +  +  +  +  +  +  A  +  +  +     +  +     +  +  +|  41        |
      Dilatation                           | 3                                4  3        3     3     2               |     10  2.9|
      Inflammation, Chronic                |                                        3                                 |      2  2.5|
      Inflammation, Suppurative            |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  47        |
      Atrophy                              |       3              2           1                                       |      9  2.1|
      Inflammation, Suppurative            |                                                       3                  |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  M  M  +  +  +  +  +  +  A  M  +  +  +  +  +  M  +  +  +|  39        |
      Mediastinal, Sinus, Infiltration     |                                                                          |            |
          Cellular                         |                                                                          |      1  2.0|
      Mesenteric, Infiltration Cellular,   |                                                                          |            |
           Histiocyte                      |                                                                          |      1  2.0|
      Renal, Inflammation, Acute           |                                        2                                 |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | M  +  +  +  M  +  M  M  M  +  +  M  +  +  A  M  M  +  +  +  M  M  M  M  +|  30        |
      Infiltration Cellular, Histiocyte    |                                     3                                   1|      2  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  M  +  M  M  M  +  +  +  +  M  M  A  M  +  M  +  +  +  M  M  +  M|  22        |
      Erythrophagocytosis                  |                                                                          |      1  2.0|
      Hyperplasia, Lymphoid                |                               2                                          |      1  2.0|
      Hyperplasia                          |                                                                          |      1  3.0|
      Infiltration Cellular, Histiocyte    |                         2  1                    2                        |      3  1.7|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  48        |
      Atrophy                              |                                                                          |      1  3.0|
      Congestion, Acute                    |          2                                                               |      1  2.0|
      Hematopoietic Cell Proliferation     | 2                                2           2        2              2   |      9  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  M  +  +  +  +  M  +  M  M  +  +  M  M  +  M  +  +  +  +  M  +  +  +|  33        |
      Cyst                                 |                                                          1               |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  +  +  M  +  +  M  M  +  M  M  M  +  M  +  +  M  M  M  M  +  +|  15        |
                                            __________________________________________________________________________|____________|
   Mammary Gland, Mandibular               |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
      Hair Follicle, Atrophy               | 4     2                                      2     3                     |      6  2.7|
      Prepuce, Cyst                        |                                                                          |      1     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  38                                                               
NTP Experiment-Test: 05078-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 05/05/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:49:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 3| 7| 3| 7| 4| 3| 7| 5| 7| 5| 5| 6| 5| 2| 3| 4| 6| 5| 4| 5| 3| 4| 5| 4|            |
                             DAY ON TEST   | 9| 2| 0| 5| 0| 6| 6| 0| 2| 0| 2| 8| 1| 0| 2| 6| 0| 7| 5| 3| 1| 3| 4| 2| 0|            |
                                           | 4| 9| 0| 8| 0| 5| 3| 0| 6| 0| 6| 7| 0| 2| 6| 3| 9| 3| 9| 4| 9| 0| 8| 4| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    15000 PP                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    M                                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Prepuce, Hyperkeratosis              |                                                                          |      1  4.0|
      Prepuce, Inflammation, Chronic       |                                                                   3      |      3  2.0|
      Prepuce, Inflammation, Necrotizing   |                                                                      4   |      2  4.0|
      Prepuce, Inflammation, Suppurative   |          3                       4                    4                  |      4  3.8|
      Prepuce, Ulcer                       |                4  3     4     3  3     4     3        4  4  4           3|     18  3.4|
      Subcutaneous Tissue, Hyperplasia,    |                                                                          |            |
           Lymphoid                        |                                                                          |      1  3.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Acute                           |                                                    2                     |      1  2.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Chronic                         |                                                                         2|      1  2.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Suppurative                     |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  48        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  48        |
      Inflammation, Suppurative            |                                                                      2   |      1  2.0|
      Thalamus, Mineralization             |             2  2  2        2  2     2  2     2                       2   |     17  2.0|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  48        |
      Submucosa, Cyst                      |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  48        |
      Hemorrhage                           |                                                                          |      1  2.0|
      Inflammation, Acute                  |                                                                          |      1  3.0|
      Inflammation, Chronic, Multifocal    |             1        2                                                   |      2  1.5|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                                                                          |      1  2.0|
      Bronchiole, Hyperplasia, Multifocal  |                                                                          |      1  2.0|
      Glands, Ectasia                      |             2                                         2                 2|      4  2.0|
      Interstitium, Inflammation, Chronic  |                                                                          |      1  2.0|
      Submucosa, Bronchus, Glands, Ectasia |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  49        |
      Glands, Cyst                         |                                                                          |      1     |
      Olfactory Epithelium, Hyperplasia    |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  39                                                               
NTP Experiment-Test: 05078-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 05/05/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:49:45  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 3| 7| 3| 7| 4| 3| 7| 5| 7| 5| 5| 6| 5| 2| 3| 4| 6| 5| 4| 5| 3| 4| 5| 4|            |
                             DAY ON TEST   | 9| 2| 0| 5| 0| 6| 6| 0| 2| 0| 2| 8| 1| 0| 2| 6| 0| 7| 5| 3| 1| 3| 4| 2| 0|            |
                                           | 4| 9| 0| 8| 0| 5| 3| 0| 6| 0| 6| 7| 0| 2| 6| 3| 9| 3| 9| 4| 9| 0| 8| 4| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    15000 PP                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    M                                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Septum, Developmental Malformation   |                                                                          |      1     |
      Submucosa, Inflammation, Chronic     |          1                                   1                           |      3  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  M  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  47        |
      Glands, Dilatation                   |                            2     2     2                                 |      4  1.8|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                            +        +                                    |   4        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |       +                    +                                             |   4        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  49        |
      Hydronephrosis                       |                                                                          |      1  1.0|
      Infarct                              |                                                                          |      2  3.0|
      Inflammation, Chronic                |                                                                          |      2  1.5|
      Inflammation, Suppurative            | 4                                      2     3                 3         |      8  3.1|
      Necrosis                             | 4                                                                        |      3  3.3|
      Nephropathy                          |       2     1        1  1     1  1              1     2           2      |     21  1.4|
      Pelvis, Inflammation, Suppurative    |    1                                                                     |      1  1.0|
      Renal Tubule, Karyomegaly            | 2  2  2     2  2  2  1  1  1  1  2  1  2        2     2  1  2     1  2  1|     40  1.6|
      Renal Tubule, Mineralization         |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Ureter                                  | +                                                                        |   1        |
      Mucosa, Inflammation, Chronic        | 3                                                                        |      1  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  47        |
      Inflammation, Acute                  |    2                                         4                           |      2  3.0|
      Inflammation, Chronic                | 3                                      4                       3         |      3  3.3|
      Inflammation, Necrotizing            |                                                                          |      1  4.0|
      Inflammation, Suppurative            |                                                                          |      2  2.5|
      Lumen, Concretion                    |                                                                          |      1  2.0|
      Transitional Epithelium, Hyperplasia | 2                                                                        |      2  1.5|
      Transitional Epithelium, Necrosis    |                                        4     4                           |      6  3.2|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  40                                                               
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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.