National Toxicology Program

National Toxicology Program
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TR 346 Mouse Pathology Tables

NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11 
LAB: Battelle Northwest                                        DATE: 09/10/94   
EXP: 05078                      ETHYL CHLORIDE                 TIME: 14:19:25   
TEST: 02              CAGES FROM 0000 TO LAST CAGE             PAGE:   1        
TEST TYPE: CHRONIC          ROUTE: RESPIRATORY EXPOSURE WHOLE  NTP C#: 06224    
CONT: N01ES38061                                               CAS: 75-00-3     
PATHOLOGIST: R. BUSCH                                                           
--------------------------------------------------------------------------------
                                                                                
                                                                                
                                                                                


REASONS FOR REMOVAL:                                                            
                                                                                
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INCLUDE ALL                                                                     

NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11
LAB: Battelle Northwest                                        DATE: 09/10/94  
EXP: 05078                      ETHYL CHLORIDE                 TIME: 14:19:25  
TEST: 02              CAGES FROM 0000 TO LAST CAGE                             
TEST TYPE: CHRONIC          ROUTE: RESPIRATORY EXPOSURE WHOLE  NTP C#: 06224   
CONT: N01ES38061                                               CAS: 75-00-3    
PATHOLOGIST: R. BUSCH                                                          

                                  ETHYL CHLORIDE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 700 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = CONTROL                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 22     CENSORED DEATHS 0    TERMINAL 28        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      17    409   409   413   479   486   516   524   526   526                 |
 |      560   560   570   578   587   610   629   646   654   658                 |
 |      668   682                                                                 |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 15000 PPM                                |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 39     CENSORED DEATHS 0    TERMINAL 11        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      226   257   261   269   278   294   308   329   330   357                 |
 |      358   360   360   360   363   363   398   409   409   409                 |
 |      434   448   465   486   502   507   519   524   526   526                 |
 |      526   559   577   587   596   610   638   671   673                       |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================

                                  ETHYL CHLORIDE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 700 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   700 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |CONTROL    |    98.0  98.0  98.0  98.0  92.0  90.0  80.0  70.0  60.0  56.0      |
 |           |                                                                    |
 |           |                                                                    |
 |15000 PPM  |   100.0 100.0  92.0  68.0  60.0  54.0  38.0  30.0  26.0  22.0      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                        DOSE                    |
 |                                                                                |
 |                                CONTROL                   15000 PPM             |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       56.0%                     22.0%                 |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P<0.001                   P<0.001               |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       532.1                     437.7                 |
 |NATURAL DEATHS (C)      |       (30.3)                    (19.8)                |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       626.1                     495.4                 |
 |(STANDARD ERROR)        |       (17.7)                    (21.9)                |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                  ETHYL CHLORIDE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 700 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = CONTROL                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 15     CENSORED DEATHS 3    TERMINAL 32        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      132   166   500   587   597   651   658   663   665   668                 |
 |      671   682   688   692   696                                               |
 |  CENSORED DEATHS                                                               |
 |      52    329   657                                                           |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 15000 PPM                                |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 48     CENSORED DEATHS 0    TERMINAL 2         |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      325   469   486   510   533   535   551   552   559   570                 |
 |      574   574   574   581   582   583   590   594   596   608                 |
 |      610   611   616   618   622   626   626   629   633   636                 |
 |      642   643   644   645   651   652   653   654   654   656                 |
 |      661   667   668   668   669   685   689   689                             |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================

                                  ETHYL CHLORIDE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 700 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   700 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |CONTROL    |   100.0  95.9  95.9  95.9  95.9  95.9  93.8  89.7  81.2  68.4      |
 |           |                                                                    |
 |           |                                                                    |
 |15000 PPM  |   100.0 100.0 100.0  98.0  98.0  96.0  88.0  62.0  18.0   4.0      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                        DOSE                    |
 |                                                                                |
 |                                CONTROL                   15000 PPM             |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       68.4%                      4.0%                 |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P<0.001                   P<0.001               |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       581.1                     605.5                 |
 |NATURAL DEATHS (C)      |       (47.2)                    ( 9.6)                |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       643.1                     609.3                 |
 |(STANDARD ERROR)        |       (21.0)                    ( 9.6)                |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                                           ETHYL CHLORIDE
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        CONTROL          = 1
                                                        15000 PPM        = 2

------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

  104 +
      |
      |  1   1                                   2
      |      1                                   2   2                          1
   96 +                                              2 2
      |                                                22
      |                                                 22                      1           1
      |                                                  2 2                                11
   88 +                                                    2  2                              1    1
      |                                                       2  2                                11
      |                                                          2 2                               11
      |                                                            2  2
   80 +                                                               22                            1    1
      |
P     |                                                                                                  1 1
E     |                                                                                                    1 1
R  72 +                                                                                                      11
C     |                                                                                                       1    1
E     |                                                                2     2                                     1 1
N     |                                                                      2  2                                    1   1
T  64 +                                                                                                                  11
      |
S     |                                                                         2  2                                      1 1
U     |                                                                            2  2                                     1  1
R  56 +                                                                               2  2                                     1 1
V     |                                                                                  2   2
I     |                                                                                      2 2
V     |                                                                                        2 2
A  48 +                                                                                          2 2
L     |
      |                                                                                            22
      |
   40 +
      |                                                                                             2    2
      |                                                                                                  2   2
      |                                                                                                      22
   32 +                                                                                                       2 2
      |                                                                                                         2  2
      |                                                                                                            2   2
      |                                                                                                                2    2
   24 +                                                                                                                     22
      |                                                                                                                      2   2
      |
      |
   16 +
      ---+-----------+-----------+-----------+-----------+-----------+-----------+-----------+-----------+-----------+-----------+--
         0          10          20          30          40          50          60          70          80          90          100

                                                                   WEEK

NOTE: 1 obs hidden.

                                                           ETHYL CHLORIDE
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        CONTROL          = 1
                                                        15000 PPM        = 2

----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 +  1                      1                                2
      |                         1     1                          2                       2
      |                               1                                                  2   2 1 2            1
      |                                                                                          2   2        1 1
   90 +                                                                                                         1        1
      |                                                                                              2  2                11
      |                                                                                                 22                11
      |                                                                                                  2 2
   80 +                                                                                                                    11
      |                                                                                                                     1  1
      |                                                                                                    2 2                 11
      |                                                                                                      22
P  70 +                                                                                                                         11
E     |                                                                                                       22                 1
R     |                                                                                                        22
C     |                                                                                                         22
E  60 +                                                                                                          2 2
N     |
T     |                                                                                                            22
      |
S  50 +                                                                                                             22
U     |
R     |                                                                                                              22
V     |
I  40 +                                                                                                               22
V     |
A     |                                                                                                                2 2
L     |
   30 +                                                                                                                  22
      |
      |
      |
   20 +                                                                                                                   22
      |                                                                                                                    22
      |
      |
   10 +                                                                                                                     2  2
      |                                                                                                                        22
      |                                                                                                                         22
      |
    0 +
      |
      ---+-----------+-----------+-----------+-----------+-----------+-----------+-----------+-----------+-----------+-----------+--
         0          10          20          30          40          50          60          70          80          90          100

                                                                   WEEK

NOTE: 3 obs hidden.

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