National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/2475

TR 346 Rat Pathology Tables


                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                           ETHYL CHLORIDE


NTP Experiment-Test: 05078-01                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:04:15




       Facility:  Battelle Northwest

       Chemical CAS #:  75-00-3

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05078-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:04:15  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   CONTROL      15000 PP                                                            
                                                                M                                                                   
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           50                                                               
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                19           24                                                               
    Natural Death                                                   4                                                               
  Survivors                                                                                                                         
    Terminal Sacrifice                                31           22                                                               
  Animals Examined Microscopically                    50           50                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large                                    (50)         (49)                                                             
      Anus, Parasite Metazoan                                       1 (2%)                                                          
   Intestine Large, Cecum                             (50)         (48)                                                             
      Parasite Metazoan                                7 (14%)      6 (13%)                                                         
   Intestine Large, Colon                             (50)         (49)                                                             
      Parasite Metazoan                                4 (8%)       7 (14%)                                                         
   Intestine Large, Rectum                            (48)         (44)                                                             
      Parasite Metazoan                                6 (13%)      3 (7%)                                                          
   Liver                                              (50)         (50)                                                             
      Angiectasis                                      1 (2%)       1 (2%)                                                          
      Basophilic Focus                                29 (58%)     22 (44%)                                                         
      Congestion                                                    1 (2%)                                                          
      Degeneration                                     2 (4%)       2 (4%)                                                          
      Degeneration, Fatty                             10 (20%)      6 (12%)                                                         
      Hematopoietic Cell Proliferation                 3 (6%)       5 (10%)                                                         
      Hepatodiaphragmatic Nodule                       3 (6%)                                                                       
      Inflammation, Focal, Granulomatous              19 (38%)     21 (42%)                                                         
      Leukocytosis                                     3 (6%)       1 (2%)                                                          
      Necrosis                                         2 (4%)       8 (16%)                                                         
      Pigmentation                                                  1 (2%)                                                          
      Thrombosis                                       2 (4%)                                                                       
      Bile Duct, Hyperplasia                           7 (14%)     12 (24%)                                                         
      Hepatocyte, Hyperplasia                          2 (4%)                                                                       
   Mesentery                                          (1)          (2)                                                              
      Fat, Inflammation, Chronic                       1 (100%)     1 (50%)                                                         
   Pancreas                                           (49)         (50)                                                             
      Atrophy                                         15 (31%)      9 (18%)                                                         
      Cytomegaly                                       1 (2%)       2 (4%)                                                          
      Hyperplasia                                                   1 (2%)                                                          
      Inflammation                                     1 (2%)                                                                       
      Artery, Mineralization                                        1 (2%)                                                          
   Pharynx                                                         (2)                                                              
      Palate, Inflammation, Chronic                                 1 (50%)                                                         
   Salivary Glands                                    (48)         (50)                                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05078-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:04:15  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   CONTROL      15000 PP                                                            
                                                                M                                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Inflammation, Chronic                                         1 (2%)                                                          
      Inflammation, Chronic, Suppurative               1 (2%)                                                                       
      Duct, Hyperplasia                                4 (8%)       6 (12%)                                                         
   Stomach, Forestomach                               (46)         (50)                                                             
      Inflammation, Chronic                            2 (4%)                                                                       
      Inflammation, Suppurative                        1 (2%)                                                                       
      Ulcer                                            1 (2%)       1 (2%)                                                          
      Epithelium, Hyperplasia                          6 (13%)      1 (2%)                                                          
   Stomach, Glandular                                 (50)         (49)                                                             
      Mineralization                                                1 (2%)                                                          
      Ulcer                                                         1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                                    (1)                                                              
      Inflammation                                                  1 (100%)                                                        
   Heart                                              (50)         (50)                                                             
      Inflammation, Chronic                           42 (84%)     41 (82%)                                                         
      Artery, Mineralization                                        1 (2%)                                                          
      Atrium, Thrombosis                                            2 (4%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (50)                                                             
      Degeneration                                                  1 (2%)                                                          
      Degeneration, Fatty                             13 (26%)     18 (36%)                                                         
      Focal Cellular Change                            1 (2%)                                                                       
      Hematopoietic Cell Proliferation                 5 (10%)      6 (12%)                                                         
      Hemorrhage                                                    1 (2%)                                                          
      Hyperplasia                                      6 (12%)      9 (18%)                                                         
      Hypertrophy                                      1 (2%)       1 (2%)                                                          
      Necrosis                                         1 (2%)                                                                       
   Adrenal Gland, Medulla                             (35)         (40)                                                             
      Hyperplasia                                      4 (11%)      3 (8%)                                                          
      Necrosis                                         1 (3%)                                                                       
   Islets, Pancreatic                                 (49)         (50)                                                             
      Hyperplasia                                      1 (2%)                                                                       
   Parathyroid Gland                                  (34)         (31)                                                             
      Hyperplasia                                                   1 (3%)                                                          
   Pituitary Gland                                    (49)         (50)                                                             
      Pars Distalis, Cyst                              3 (6%)       4 (8%)                                                          
      Pars Distalis, Hemorrhage                                     1 (2%)                                                          
      Pars Distalis, Hyperplasia                      10 (20%)     11 (22%)                                                         
      Pars Distalis, Infiltration Cellular, Mixed                                                                                   
          Cell                                                      1 (2%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05078-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:04:15  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   CONTROL      15000 PP                                                            
                                                                M                                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Pars Distalis, Metaplasia, Osseous               1 (2%)                                                                       
      Pars Distalis, Pigmentation, Hemosiderin         1 (2%)       2 (4%)                                                          
   Thyroid Gland                                      (49)         (48)                                                             
      Mineralization                                                1 (2%)                                                          
      C-Cell, Hyperplasia                             33 (67%)     31 (65%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (46)         (43)                                                             
      Cyst                                             2 (4%)                                                                       
      Hyperplasia                                      1 (2%)       1 (2%)                                                          
      Inflammation, Suppurative                        4 (9%)       3 (7%)                                                          
      Duct, Hyperplasia                                1 (2%)       1 (2%)                                                          
   Ovary                                              (49)         (50)                                                             
      Atrophy                                          1 (2%)       4 (8%)                                                          
      Cyst                                             2 (4%)       5 (10%)                                                         
      Interstitium, Hyperplasia                        2 (4%)       1 (2%)                                                          
   Uterus                                             (49)         (50)                                                             
      Hemorrhage                                       1 (2%)                                                                       
      Inflammation, Suppurative                        1 (2%)                                                                       
      Endometrium, Hyperplasia                         1 (2%)       1 (2%)                                                          
      Endometrium, Hyperplasia, Cystic                 1 (2%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)                                                             
      Infiltration Cellular, Histiocyte                             1 (2%)                                                          
      Myelofibrosis                                    2 (4%)                                                                       
   Lymph Node                                         (48)         (49)                                                             
      Mesenteric, Angiectasis                          1 (2%)                                                                       
      Mesenteric, Inflammation, Granulomatous          1 (2%)                                                                       
      Renal, Inflammation, Granulomatous               1 (2%)                                                                       
   Lymph Node, Bronchial                              (47)         (47)                                                             
      Congestion                                       1 (2%)       1 (2%)                                                          
      Hyperplasia                                      1 (2%)       1 (2%)                                                          
      Inflammation, Granulomatous                      1 (2%)                                                                       
   Lymph Node, Mandibular                             (39)         (43)                                                             
      Angiectasis                                      1 (3%)                                                                       
      Depletion Cellular                                            1 (2%)                                                          
      Hyperplasia                                      9 (23%)      8 (19%)                                                         
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05078-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:04:15  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   CONTROL      15000 PP                                                            
                                                                M                                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
   Spleen                                             (50)         (50)                                                             
      Fibrosis                                         1 (2%)                                                                       
      Hematocyst                                                    1 (2%)                                                          
      Hematopoietic Cell Proliferation                 1 (2%)       7 (14%)                                                         
      Inflammation, Focal, Granulomatous               1 (2%)       2 (4%)                                                          
      Pigmentation, Hemosiderin                                     2 (4%)                                                          
   Thymus                                             (38)         (39)                                                             
      Epithelial Cell, Hyperplasia                     1 (3%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (48)         (50)                                                             
      Hyperplasia                                     45 (94%)     47 (94%)                                                         
   Skin                                               (47)         (49)                                                             
      Acanthosis                                       2 (4%)       2 (4%)                                                          
      Inflammation                                     1 (2%)                                                                       
      Inflammation, Suppurative                                     3 (6%)                                                          
      Subcutaneous Tissue, Inflammation, Chronic       1 (2%)                                                                       
      Subcutaneous Tissue, Inflammation,                                                                                            
          Granulomatous                                1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)                                                             
      Fibrous Osteodystrophy                                        1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)                                                             
      Gliosis                                                       1 (2%)                                                          
      Hemorrhage, Focal                                2 (4%)       2 (4%)                                                          
      Inflammation                                                  1 (2%)                                                          
      Necrosis, Focal                                  1 (2%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (50)         (49)                                                             
      Inflammation, Suppurative                       10 (20%)      7 (14%)                                                         
      Metaplasia, Squamous                             1 (2%)                                                                       
      Epithelium, Hyperplasia                                       2 (4%)                                                          
      Submucosa, Inflammation                          1 (2%)       1 (2%)                                                          
   Lung                                               (50)         (50)                                                             
      Congestion                                                    2 (4%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05078-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:04:15  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   CONTROL      15000 PP                                                            
                                                                M                                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Edema                                            1 (2%)       2 (4%)                                                          
      Foreign Body                                     1 (2%)                                                                       
      Hemorrhage                                                    4 (8%)                                                          
      Infiltration Cellular, Histiocyte                8 (16%)     13 (26%)                                                         
      Inflammation, Chronic, Diffuse                   1 (2%)       1 (2%)                                                          
      Inflammation, Chronic, Focal                     4 (8%)       4 (8%)                                                          
      Inflammation, Granulomatous                      1 (2%)                                                                       
      Mineralization                                                1 (2%)                                                          
      Necrosis                                                      1 (2%)                                                          
      Thrombosis                                                    1 (2%)                                                          
      Alveolar Epithelium, Hyperplasia                 4 (8%)       8 (16%)                                                         
      Bronchiole, Epithelium, Hyperplasia                           1 (2%)                                                          
      Mediastinum, Infiltration Cellular,                                                                                           
          Mononuclear Cell                             1 (2%)                                                                       
      Perivascular, Infiltration Cellular,                                                                                          
          Mononuclear Cell                            21 (42%)     19 (38%)                                                         
   Nose                                               (50)         (50)                                                             
      Inflammation, Suppurative                        6 (12%)      6 (12%)                                                         
      Thrombosis                                       2 (4%)       5 (10%)                                                         
      Nasolacrimal Duct, Inflammation, Suppurative    12 (24%)     10 (20%)                                                         
      Respiratory Epithelium, Hyperplasia              4 (8%)      10 (20%)                                                         
      Respiratory Epithelium, Metaplasia, Squamous     2 (4%)       1 (2%)                                                          
      Submucosa, Inflammation                         25 (50%)     34 (68%)                                                         
      Vomeronasal Organ, Inflammation, Suppurative     1 (2%)       1 (2%)                                                          
   Trachea                                            (50)         (49)                                                             
      Inflammation, Suppurative                        2 (4%)       1 (2%)                                                          
      Epithelium, Hyperplasia                                       1 (2%)                                                          
      Submucosa, Inflammation                                       2 (4%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (3)          (5)                                                              
      Cataract                                         1 (33%)      2 (40%)                                                         
      Hemorrhage                                                    1 (20%)                                                         
      Inflammation, Chronic                                         1 (20%)                                                         
      Synechia                                         1 (33%)      1 (20%)                                                         
      Bilateral, Cataract                              1 (33%)      1 (20%)                                                         
      Retina, Atrophy                                  1 (33%)      2 (40%)                                                         
   Harderian Gland                                                 (1)                                                              
      Inflammation, Suppurative                                     1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05078-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:04:15  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   CONTROL      15000 PP                                                            
                                                                M                                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)                                                             
      Hydronephrosis                                                1 (2%)                                                          
      Inflammation, Suppurative                        2 (4%)                                                                       
      Mineralization                                                1 (2%)                                                          
      Nephropathy                                     47 (94%)     42 (84%)                                                         
      Renal Tubule, Hyperplasia, Focal                 1 (2%)       2 (4%)                                                          
   Urinary Bladder                                    (49)         (49)                                                             
      Hemorrhage                                                    1 (2%)                                                          
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05078-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:04:15  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      15000 PP                                                            
                                                                M                                                                   
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           50                                                               
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                28           33                                                               
    Natural Death                                      6            9                                                               
  Survivors                                                                                                                         
    Terminal Sacrifice                                16            8                                                               
  Animals Examined Microscopically                    50           50                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (49)         (45)                                                             
      Parasite Metazoan                                8 (16%)      4 (9%)                                                          
   Intestine Large, Colon                             (50)         (45)                                                             
      Parasite Metazoan                                5 (10%)      5 (11%)                                                         
   Intestine Large, Rectum                            (47)         (43)                                                             
      Parasite Metazoan                                4 (9%)       5 (12%)                                                         
      Serosa, Inflammation, Chronic                    1 (2%)       1 (2%)                                                          
      Serosa, Thrombosis                               1 (2%)                                                                       
   Liver                                              (50)         (50)                                                             
      Angiectasis                                                   1 (2%)                                                          
      Basophilic Focus                                18 (36%)      7 (14%)                                                         
      Clear Cell Focus                                 3 (6%)       2 (4%)                                                          
      Congestion                                                    2 (4%)                                                          
      Degeneration                                     2 (4%)       2 (4%)                                                          
      Degeneration, Cystic                             3 (6%)       9 (18%)                                                         
      Degeneration, Fatty                              9 (18%)      5 (10%)                                                         
      Fibrosis                                         1 (2%)                                                                       
      Hematopoietic Cell Proliferation                              3 (6%)                                                          
      Hemorrhage                                       1 (2%)                                                                       
      Hepatodiaphragmatic Nodule                       2 (4%)       2 (4%)                                                          
      Inflammation, Focal, Granulomatous               6 (12%)      5 (10%)                                                         
      Necrosis                                         7 (14%)      4 (8%)                                                          
      Pigmentation                                                  1 (2%)                                                          
      Bile Duct, Hyperplasia                          44 (88%)     34 (68%)                                                         
      Hepatocyte, Hyperplasia                          3 (6%)       8 (16%)                                                         
   Pancreas                                           (50)         (49)                                                             
      Atrophy                                         24 (48%)     17 (35%)                                                         
      Cytomegaly                                       2 (4%)       1 (2%)                                                          
      Inflammation                                                  1 (2%)                                                          
      Pigmentation, Hemosiderin                        1 (2%)       1 (2%)                                                          
      Artery, Intima, Hyperplasia                      1 (2%)                                                                       
      Perivascular, Inflammation                                    3 (6%)                                                          
   Pharynx                                            (2)          (1)                                                              
      Inflammation, Suppurative                                     1 (100%)                                                        
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05078-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:04:15  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      15000 PP                                                            
                                                                M                                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Palate, Inflammation, Chronic                    2 (100%)                                                                     
   Salivary Glands                                    (50)         (50)                                                             
      Duct, Hyperplasia                               10 (20%)     15 (30%)                                                         
      Duct, Inflammation, Suppurative                  2 (4%)       1 (2%)                                                          
   Stomach, Forestomach                               (48)         (49)                                                             
      Hyperkeratosis                                                1 (2%)                                                          
      Inflammation, Chronic                            2 (4%)                                                                       
      Inflammation, Suppurative                        3 (6%)       1 (2%)                                                          
      Ulcer                                            4 (8%)       1 (2%)                                                          
      Epithelium, Hyperplasia                          2 (4%)       2 (4%)                                                          
      Serosa, Inflammation, Chronic                                 1 (2%)                                                          
   Stomach, Glandular                                 (50)         (50)                                                             
      Erosion                                                       3 (6%)                                                          
      Hyperplasia, Lymphoid                                         1 (2%)                                                          
      Mineralization                                                2 (4%)                                                          
      Epithelium, Hyperplasia                                       1 (2%)                                                          
      Serosa, Inflammation, Chronic                                 1 (2%)                                                          
   Tooth                                              (3)                                                                           
      Gingiva, Hyperplasia, Pseudoepitheliomatous      1 (33%)                                                                      
      Peridontal Tissue, Inflammation, Chronic,                                                                                     
           Suppurative                                 2 (67%)                                                                      
      Pulp, Inflammation, Suppurative                  1 (33%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)                                                             
      Inflammation, Chronic                           43 (86%)     46 (92%)                                                         
      Artery, Mineralization                                        1 (2%)                                                          
      Atrium, Thrombosis                               2 (4%)       2 (4%)                                                          
      Perivascular, Inflammation                       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (50)                                                             
      Degeneration, Fatty                             23 (46%)     26 (52%)                                                         
      Hematopoietic Cell Proliferation                 2 (4%)       2 (4%)                                                          
      Hyperplasia                                     13 (26%)      6 (12%)                                                         
      Hypertrophy                                      2 (4%)                                                                       
   Adrenal Gland, Medulla                             (36)         (48)                                                             
      Hematopoietic Cell Proliferation                              1 (2%)                                                          
      Hyperplasia                                     11 (31%)     16 (33%)                                                         
   Islets, Pancreatic                                 (48)         (48)                                                             
      Hyperplasia                                      3 (6%)       4 (8%)                                                          
   Parathyroid Gland                                  (31)         (41)                                                             
      Hyperplasia                                                   3 (7%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05078-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:04:15  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      15000 PP                                                            
                                                                M                                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
   Pituitary Gland                                    (49)         (50)                                                             
      Pars Distalis, Cyst                              1 (2%)       2 (4%)                                                          
      Pars Distalis, Hemorrhage                        1 (2%)       1 (2%)                                                          
      Pars Distalis, Hyperplasia                      10 (20%)     10 (20%)                                                         
      Pars Distalis, Inflammation, Suppurative                      1 (2%)                                                          
      Pars Distalis, Necrosis                          1 (2%)                                                                       
      Pars Distalis, Pigmentation, Hemosiderin                      1 (2%)                                                          
   Thyroid Gland                                      (49)         (47)                                                             
      C-Cell, Hyperplasia                             19 (39%)     23 (49%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (1)          (4)                                                              
      Inflammation, Chronic                            1 (100%)     1 (25%)                                                         
      Necrosis                                         1 (100%)     1 (25%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (37)         (42)                                                             
      Granuloma Sperm                                               1 (2%)                                                          
      Inflammation, Chronic                            1 (3%)                                                                       
      Mineralization                                   1 (3%)                                                                       
      Vacuolization Cytoplasmic                       14 (38%)     15 (36%)                                                         
   Penis                                                           (1)                                                              
      Inflammation, Suppurative                                     1 (100%)                                                        
   Preputial Gland                                    (47)         (45)                                                             
      Cyst                                             1 (2%)       1 (2%)                                                          
      Inflammation, Suppurative                       10 (21%)      3 (7%)                                                          
      Duct, Hyperplasia                                             1 (2%)                                                          
   Prostate                                           (50)         (48)                                                             
      Hyperplasia                                      4 (8%)      11 (23%)                                                         
      Inflammation, Chronic                            1 (2%)                                                                       
      Inflammation, Suppurative                       16 (32%)     13 (27%)                                                         
   Seminal Vesicle                                    (7)          (6)                                                              
      Inflammation, Suppurative                        7 (100%)     5 (83%)                                                         
   Testes                                             (50)         (50)                                                             
      Atrophy                                         27 (54%)     29 (58%)                                                         
      Interstitial Cell, Hyperplasia                  12 (24%)     15 (30%)                                                         
      Perivascular, Inflammation                       3 (6%)       8 (16%)                                                         
      Tunic, Hyperplasia                                            1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05078-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:04:15  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      15000 PP                                                            
                                                                M                                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (48)                                                             
      Hyperplasia                                                   1 (2%)                                                          
      Myelofibrosis                                    1 (2%)       1 (2%)                                                          
   Lymph Node                                         (49)         (50)                                                             
      Mesenteric, Hematopoietic Cell Proliferation     1 (2%)                                                                       
      Mesenteric, Inflammation, Granulomatous                       1 (2%)                                                          
      Pancreatic, Hyperplasia                          1 (2%)                                                                       
      Renal, Hematopoietic Cell Proliferation          1 (2%)                                                                       
   Lymph Node, Bronchial                              (42)         (48)                                                             
      Hyperplasia                                      2 (5%)       2 (4%)                                                          
      Pigmentation, Hemosiderin                        1 (2%)                                                                       
   Lymph Node, Mandibular                             (45)         (38)                                                             
      Angiectasis                                      1 (2%)       2 (5%)                                                          
      Hyperplasia                                     19 (42%)     11 (29%)                                                         
   Spleen                                             (50)         (50)                                                             
      Fibrosis                                         3 (6%)       9 (18%)                                                         
      Hematocyst                                                    1 (2%)                                                          
      Hematopoietic Cell Proliferation                 2 (4%)       2 (4%)                                                          
   Thymus                                             (39)         (41)                                                             
      Epithelial Cell, Hyperplasia                     1 (3%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (13)         (14)                                                             
      Galactocele                                                   3 (21%)                                                         
      Hyperplasia                                      8 (62%)     10 (71%)                                                         
   Skin                                               (49)         (46)                                                             
      Acanthosis                                       1 (2%)                                                                       
      Ectopic Tissue                                                1 (2%)                                                          
      Inflammation, Chronic                            1 (2%)       1 (2%)                                                          
      Pigmentation, Hemosiderin                        1 (2%)                                                                       
      Prepuce, Abscess                                 1 (2%)                                                                       
      Prepuce, Epithelium, Hyperplasia                 1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (49)                                                             
      Fibrous Osteodystrophy                                        4 (8%)                                                          
      Hyperostosis                                                  1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
NTP Experiment-Test: 05078-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:04:15  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      15000 PP                                                            
                                                                M                                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)                                                             
      Hemorrhage, Focal                                3 (6%)       3 (6%)                                                          
      Hydrocephalus                                    1 (2%)                                                                       
      Necrosis, Focal                                  2 (4%)                                                                       
      Meninges, Hemorrhage                             1 (2%)                                                                       
      Meninges, Inflammation, Suppurative              1 (2%)                                                                       
      Meninges, Pigmentation, Hemosiderin                           1 (2%)                                                          
   Spinal Cord                                                     (1)                                                              
      Degeneration                                                  1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (49)         (44)                                                             
      Inflammation, Suppurative                       14 (29%)     21 (48%)                                                         
      Metaplasia, Squamous                                          1 (2%)                                                          
   Lung                                               (50)         (50)                                                             
      Congestion                                       1 (2%)       5 (10%)                                                         
      Edema                                            1 (2%)       2 (4%)                                                          
      Erythrophagocytosis                                           1 (2%)                                                          
      Hemorrhage                                       4 (8%)       3 (6%)                                                          
      Infiltration Cellular, Histiocyte                5 (10%)     13 (26%)                                                         
      Infiltration Cellular, Mixed Cell                1 (2%)       1 (2%)                                                          
      Inflammation, Chronic, Focal                     4 (8%)       2 (4%)                                                          
      Metaplasia, Osseous                              1 (2%)       2 (4%)                                                          
      Alveolar Epithelium, Hyperplasia                 6 (12%)      7 (14%)                                                         
      Artery, Mediastinum, Mineralization                           1 (2%)                                                          
      Bronchiole, Inflammation, Suppurative                         1 (2%)                                                          
      Perivascular, Infiltration Cellular,                                                                                          
          Mononuclear Cell                             9 (18%)     14 (28%)                                                         
   Nose                                               (50)         (49)                                                             
      Edema                                            1 (2%)                                                                       
      Inflammation, Suppurative                       12 (24%)     13 (27%)                                                         
      Thrombosis                                       8 (16%)      7 (14%)                                                         
      Nasolacrimal Duct, Inflammation, Suppurative    12 (24%)      8 (16%)                                                         
      Respiratory Epithelium, Hyperplasia              9 (18%)     14 (29%)                                                         
      Respiratory Epithelium, Metaplasia, Squamous     1 (2%)                                                                       
      Submucosa, Inflammation                         22 (44%)     23 (47%)                                                         
      Vomeronasal Organ, Inflammation, Suppurative     2 (4%)       1 (2%)                                                          
   Trachea                                            (50)         (49)                                                             
      Inflammation, Suppurative                        2 (4%)       7 (14%)                                                         
      Epithelium, Hyperplasia                                       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   12                                                              
NTP Experiment-Test: 05078-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:04:15  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      15000 PP                                                            
                                                                M                                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (1)          (7)                                                              
      Cataract                                                      1 (14%)                                                         
      Degeneration                                     1 (100%)     1 (14%)                                                         
      Inflammation, Chronic                                         1 (14%)                                                         
      Synechia                                                      4 (57%)                                                         
      Bilateral, Cataract                                           3 (43%)                                                         
      Retina, Atrophy                                               3 (43%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)                                                             
      Fatty Change                                     1 (2%)                                                                       
      Hematopoietic Cell Proliferation                 2 (4%)       3 (6%)                                                          
      Hydronephrosis                                                1 (2%)                                                          
      Inflammation, Suppurative                        4 (8%)       3 (6%)                                                          
      Nephropathy                                     49 (98%)     49 (98%)                                                         
      Pelvis, Inflammation, Suppurative                2 (4%)                                                                       
      Pelvis, Necrosis                                 1 (2%)                                                                       
      Pelvis, Epithelium, Hyperplasia                  1 (2%)       3 (6%)                                                          
   Urethra                                            (1)                                                                           
      Inflammation, Suppurative                        1 (100%)                                                                     
      Epithelium, Hyperplasia                          1 (100%)                                                                     
   Urinary Bladder                                    (50)         (49)                                                             
      Hemorrhage                                                    1 (2%)                                                          
      Inflammation                                                  1 (2%)                                                          
      Inflammation, Suppurative                        2 (4%)       1 (2%)                                                          
      Transitional Epithelium, Hyperplasia             1 (2%)       2 (4%)                                                          
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   13                                                              
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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.