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TR 346 Rat Pathology Tables

NTP Experiment-Test: 05078-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 05/05/97
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:10:54




       Facility:  Battelle Northwest

       Chemical CAS #:  75-00-3

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































Note:  Animals arranged according to CID number

                                                              Page   1

NTP Experiment-Test: 05078-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 05/05/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:10:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 2| 7| 6| 7| 6| 7| 7| 6| 6| 6| 7| 7|             
                             DAY ON TEST   | 2| 1| 6| 2| 2| 2| 2| 2| 1| 2| 2| 2| 6| 5| 2| 5| 2| 5| 2| 2| 5| 3| 5| 2| 2|             
                                           | 9| 1| 8| 9| 9| 9| 9| 9| 6| 9| 9| 9| 8| 1| 9| 9| 9| 4| 9| 9| 9| 3| 7| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Sarcoma, Metastatic, Bone            |                                                                   X      |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  I  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Sarcoma, Metastatic, Tissue NOS      |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma             |                                                                          |             
      Leukemia Mononuclear                 | X     X                 X     X              X  X  X        X           X|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                        X                                 |             
      Sarcoma, Metastatic, Bone            |                                                                   X      |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X                                            X                     |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                        X                                 |             
      Sarcoma, Metastatic, Tissue NOS      |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
      Squamous Cell Papilloma              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X                                         X  X                     |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Lymphoma Malignant          |                                                                          |             
          Undifferentiated Cell Type       |                                        X                                 |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                            X                                             |             
      Leukemia Mononuclear                 |       X                 X                       X           X            |             
      Sarcoma, Metastatic, Bone            |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05078-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 05/05/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:10:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 2| 7| 6| 7| 6| 7| 7| 6| 6| 6| 7| 7|             
                             DAY ON TEST   | 2| 1| 6| 2| 2| 2| 2| 2| 1| 2| 2| 2| 6| 5| 2| 5| 2| 5| 2| 2| 5| 3| 5| 2| 2|             
                                           | 9| 1| 8| 9| 9| 9| 9| 9| 6| 9| 9| 9| 8| 1| 9| 9| 9| 4| 9| 9| 9| 3| 7| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | M  M  +  +  +  M  +  +  +  +  +  I  +  +  +  +  M  +  +  +  M  +  +  M  M|             
      Leukemia Mononuclear                 |       X                                            X                     |             
      Pheochromocytoma Benign              |                                                                          |             
      Sarcoma, Metastatic, Bone            |                                                                   X      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                   X                                                      |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  M  +  +  +  +  +  +  +  I  +  M  M  +  +  +  M  +  M  +  M  +  M  M  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               | X  X           X  X     X        X  X                 X  X  X     X  X  X|             
      Pars Distalis, Carcinoma             |             X                                X                 X         |             
      Pars Distalis, Leukemia Mononuclear  |                                                             X            |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                        X                                 |             
      C-Cell, Adenoma                      | X                                                        X               |             
      C-Cell, Carcinoma                    |                                  X           X                           |             
      Follicular Cell, Adenoma             |                                                                          |             
      Follicular Cell, Carcinoma           |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
      Sarcoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  M  +  +|             
      Adenoma                              |                            X                                             |             
      Carcinoma                            |                                     X                                X   |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Leukemia Mononuclear                 |                                                 X           X            |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                        X                                 |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Leukemia Mononuclear                 |                                                    X        X            |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                        X                                 |             
      Polyp Stromal                        |                      X                                                   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X                                                                  |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                        X                                 |             
      Sarcoma, Metastatic, Bone            |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05078-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 05/05/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:10:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 2| 7| 6| 7| 6| 7| 7| 6| 6| 6| 7| 7|             
                             DAY ON TEST   | 2| 1| 6| 2| 2| 2| 2| 2| 1| 2| 2| 2| 6| 5| 2| 5| 2| 5| 2| 2| 5| 3| 5| 2| 2|             
                                           | 9| 1| 8| 9| 9| 9| 9| 9| 6| 9| 9| 9| 8| 1| 9| 9| 9| 4| 9| 9| 9| 3| 7| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                        X                                 |             
      Mediastinal, Leukemia Mononuclear    |                                                                          |             
      Mesenteric, Leukemia Mononuclear     |       X                                                                  |             
      Mesenteric, Lymphoma Malignant       |                                                                          |             
          Undifferentiated Cell Type       |                                        X                                 |             
      Pancreatic, Leukemia Mononuclear     |                                                    X                     |             
      Renal, Lymphoma Malignant            |                                                                          |             
          Undifferentiated Cell Type       |                                        X                                 |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +|             
      Leukemia Mononuclear                 |       X                                      X                           |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                        X                                 |             
      Sarcoma, Metastatic, Bone            |                                                                   X      |             
      Mesenteric, Sarcoma, Metastatic,     |                                                                          |             
           Tissue NOS                      |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  M  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  M  I  M  +|             
      Leukemia Mononuclear                 |       X                                         X                        |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                        X                                 |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                                          |             
      Leukemia Mononuclear                 | X     X                 X     X              X  X  X        X           X|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                        X                                 |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +  +  +  +  +  M  +  M  +  +  +  +  +  M  +  +  M  +  +  M  +  +  I|             
      Leukemia Mononuclear                 |       X                                            X                     |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                        X                                 |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Fibroadenoma                         |             X                       X           X                 X  X  X|             
      Fibroadenoma, Multiple               |             X                                                            |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Fibroma         |                            X                                             |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Osteosarcoma                         |                                                                   X      |             
      Periosteum, Leukemia Mononuclear     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05078-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 05/05/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:10:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 2| 7| 6| 7| 6| 7| 7| 6| 6| 6| 7| 7|             
                             DAY ON TEST   | 2| 1| 6| 2| 2| 2| 2| 2| 1| 2| 2| 2| 6| 5| 2| 5| 2| 5| 2| 2| 5| 3| 5| 2| 2|             
                                           | 9| 1| 8| 9| 9| 9| 9| 9| 6| 9| 9| 9| 8| 1| 9| 9| 9| 4| 9| 9| 9| 3| 7| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Pituitary     |                                                                          |             
          Gland                            |             X                                X                 X         |             
      Leukemia Mononuclear                 |       X                                                                  |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Thyroid Gland |                                  X                                       |             
      Leukemia Mononuclear                 | X     X                 X                    X  X  X        X           X|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                        X                                 |             
      Sarcoma, Metastatic, Bone            |                                                                   X      |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X                                      X              X            |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                         +|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X                                      X     X        X            |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                        X                                 |             
      Sarcoma, Metastatic, Bone            |                                                                   X      |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X     X                 X     X              X  X  X        X           X|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                        X                                 |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05078-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 05/05/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:10:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 7| 7| 7| 7| 6| 7| 5| 5| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 5| 7| 7| 7|            |
                             DAY ON TEST   | 6| 3| 2| 2| 2| 2| 2| 8| 2| 8| 4| 2| 2| 2| 2| 4| 2| 0| 7| 2| 2| 4| 2| 2| 2|            |
                                           | 1| 0| 9| 9| 9| 9| 9| 8| 9| 7| 0| 9| 9| 9| 9| 3| 9| 3| 4| 9| 9| 5| 9| 9| 9|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|     A      |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Sarcoma, Metastatic, Bone            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  47        |
      Sarcoma, Metastatic, Tissue NOS      |                      X                                                   |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hepatocellular Carcinoma             |                                                             X            |          1 |
      Leukemia Mononuclear                 | X  X     X  X              X        X  X           X  X     X            |         19 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
      Sarcoma, Metastatic, Bone            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                       +                  |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +|  49        |
      Leukemia Mononuclear                 | X        X                 X           X                                 |          6 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
      Sarcoma, Metastatic, Tissue NOS      |                      X                                                   |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|  46        |
      Leukemia Mononuclear                 | X        X                                            X                  |          3 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 | X        X                                            X                  |          3 |
                                            __________________________________________________________________________|____________|
   Tongue                                  |                      +                                                   |   1        |
      Squamous Cell Papilloma              |                      X                                                   |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 | X  X     X  X              X           X              X                  |         10 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Capsule, Lymphoma Malignant          |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page   6                                                               
NTP Experiment-Test: 05078-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 05/05/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:10:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 7| 7| 7| 7| 6| 7| 5| 5| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 5| 7| 7| 7|            |
                             DAY ON TEST   | 6| 3| 2| 2| 2| 2| 2| 8| 2| 8| 4| 2| 2| 2| 2| 4| 2| 0| 7| 2| 2| 4| 2| 2| 2|            |
                                           | 1| 0| 9| 9| 9| 9| 9| 8| 9| 7| 0| 9| 9| 9| 9| 3| 9| 3| 4| 9| 9| 5| 9| 9| 9|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|     A      |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
          Undifferentiated Cell Type       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenoma                              | X                                                                        |          2 |
      Leukemia Mononuclear                 |             X              X                                             |          6 |
      Sarcoma, Metastatic, Bone            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  M  +  M  +  +  +  +  +  +  I  +  +  +  M  +  +  +  I  +  +  M  I|  35        |
      Leukemia Mononuclear                 | X           X              X           X              X                  |          7 |
      Pheochromocytoma Benign              |                                           X                              |          1 |
      Sarcoma, Metastatic, Bone            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|  49        |
      Carcinoma                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  M  +  +  +  +  +  +  +  M  M  M  +  +  +  +  +  +  +  +  M  +  M  +|  34        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Pars Distalis, Adenoma               |          X  X     X  X     X  X  X        X     X        X  X     X  X   |         26 |
      Pars Distalis, Carcinoma             |                                              X     X           X         |          6 |
      Pars Distalis, Leukemia Mononuclear  | X                                      X              X                  |          4 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |          X                                                               |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
      C-Cell, Adenoma                      |       X     X                          X                                 |          5 |
      C-Cell, Carcinoma                    |                   X                                                      |          3 |
      Follicular Cell, Adenoma             |                                              X                           |          1 |
      Follicular Cell, Carcinoma           |                                        X                                 |          2 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                      +                                                   |   1        |
      Sarcoma                              |                      X                                                   |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Adenoma                              |                                                                          |          1 |
      Carcinoma                            |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 | X        X  X                                         X                  |          6 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 | X        X                                            X                  |          5 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page   7                                                               
NTP Experiment-Test: 05078-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 05/05/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:10:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 7| 7| 7| 7| 6| 7| 5| 5| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 5| 7| 7| 7|            |
                             DAY ON TEST   | 6| 3| 2| 2| 2| 2| 2| 8| 2| 8| 4| 2| 2| 2| 2| 4| 2| 0| 7| 2| 2| 4| 2| 2| 2|            |
                                           | 1| 0| 9| 9| 9| 9| 9| 8| 9| 7| 0| 9| 9| 9| 9| 3| 9| 3| 4| 9| 9| 5| 9| 9| 9|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|     A      |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
      Polyp Stromal                        |                               X                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                            X                                             |          2 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
      Sarcoma, Metastatic, Bone            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|  48        |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
      Mediastinal, Leukemia Mononuclear    |          X                                                               |          1 |
      Mesenteric, Leukemia Mononuclear     | X                                                                        |          2 |
      Mesenteric, Lymphoma Malignant       |                                                                          |            |
          Undifferentiated Cell Type       |                                                                          |          1 |
      Pancreatic, Leukemia Mononuclear     |                                                                          |          1 |
      Renal, Lymphoma Malignant            |                                                                          |            |
          Undifferentiated Cell Type       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|  47        |
      Leukemia Mononuclear                 | X        X  X              X           X              X                  |          8 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
      Sarcoma, Metastatic, Bone            |                                                                          |          1 |
      Mesenteric, Sarcoma, Metastatic,     |                                                                          |            |
           Tissue NOS                      |                      X                                                   |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  M  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  M  M  +  +  +|  39        |
      Leukemia Mononuclear                 | X        X                                            X                  |          5 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemangiosarcoma                      |                                                             X            |          1 |
      Leukemia Mononuclear                 | X  X     X  X              X     X  X  X           X  X                  |         19 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  M  M  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  M|  38        |
      Leukemia Mononuclear                 | X        X                 X                                             |          5 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page   8                                                               
NTP Experiment-Test: 05078-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 05/05/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:10:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 7| 7| 7| 7| 6| 7| 5| 5| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 5| 7| 7| 7|            |
                             DAY ON TEST   | 6| 3| 2| 2| 2| 2| 2| 8| 2| 8| 4| 2| 2| 2| 2| 4| 2| 0| 7| 2| 2| 4| 2| 2| 2|            |
                                           | 1| 0| 9| 9| 9| 9| 9| 8| 9| 7| 0| 9| 9| 9| 9| 3| 9| 3| 4| 9| 9| 5| 9| 9| 9|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|     A      |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Adenoma                              |          X  X                                                            |          2 |
      Fibroadenoma                         |                                     X        X        X  X     X         |         11 |
      Fibroadenoma, Multiple               |                                                                          |          1 |
      Leukemia Mononuclear                 |                            X                                             |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Subcutaneous Tissue, Fibroma         |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Osteosarcoma                         |                                                                          |          1 |
      Periosteum, Leukemia Mononuclear     | X        X                 X                                             |          3 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Carcinoma, Metastatic, Pituitary     |                                                                          |            |
          Gland                            |                                              X                 X         |          5 |
      Leukemia Mononuclear                 | X                                                     X                  |          3 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Carcinoma, Metastatic, Thyroid Gland |                                                                          |          1 |
      Leukemia Mononuclear                 | X  X     X  X              X           X              X                  |         15 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
      Sarcoma, Metastatic, Bone            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                  +  M                          +         |   3        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page   9                                                               
NTP Experiment-Test: 05078-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 05/05/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:10:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 7| 7| 7| 7| 6| 7| 5| 5| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 5| 7| 7| 7|            |
                             DAY ON TEST   | 6| 3| 2| 2| 2| 2| 2| 8| 2| 8| 4| 2| 2| 2| 2| 4| 2| 0| 7| 2| 2| 4| 2| 2| 2|            |
                                           | 1| 0| 9| 9| 9| 9| 9| 8| 9| 7| 0| 9| 9| 9| 9| 3| 9| 3| 4| 9| 9| 5| 9| 9| 9|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|     A      |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Leukemia Mononuclear                 |             X                                         X                  |          6 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
      Sarcoma, Metastatic, Bone            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 | X        X                 X                                             |          3 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 | X  X     X  X              X     X  X  X           X  X     X            |         20 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  10                                                               
NTP Experiment-Test: 05078-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 05/05/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:10:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 5| 7| 6| 5| 5| 7| 7| 7| 6| 6| 5| 5| 7| 6| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 2| 2| 3| 8| 9| 0| 8| 7| 5| 3| 3| 3| 8| 1| 9| 7| 3| 5| 3|             
                                           | 0| 0| 0| 0| 0| 0| 0| 3| 0| 8| 4| 7| 9| 4| 9| 0| 0| 0| 8| 2| 9| 3| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    15000 PP                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    M                                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Leukemia Mononuclear                 |                X                                                         |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  A  M  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  A  A  +  +  +  +|             
      Leukemia Mononuclear                 |                X                                                         |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Histiocytoma, Metastatic,    |                                                                          |             
           Uncertain Primary Site          |                                           X                              |             
      Fibrous Histiocytoma, Metastatic,    |                                                                          |             
           Skeletal Muscle                 |                                                                          |             
      Leukemia Lymphocytic                 |                                                                          |             
      Leukemia Mononuclear                 | X  X  X  X  X  X  X  X     X     X              X  X     X  X     X     X|             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Schwannoma Malignant, Metastatic,    |                                                                          |             
           Stomach                         |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Histiocytoma, Metastatic,    |                                                                          |             
           Uncertain Primary Site          |                                           X                              |             
      Leukemia Mononuclear                 |                X  X  X                                                   |             
      Schwannoma Malignant, Metastatic,    |                                                                          |             
           Stomach                         |                                                                          |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                +                                                         |             
      Palate, Squamous Cell Papilloma      |                X                                                         |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Schwannoma Malignant                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                          X               |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                        +                                 |             
      Squamous Cell Papilloma              |                                        X                                 |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                    +                     |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Histiocytoma, Metastatic,    |                                                                          |             
           Uncertain Primary Site          |                                           X                              |             
      Leukemia Lymphocytic                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  11                                                               
NTP Experiment-Test: 05078-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 05/05/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:10:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 5| 7| 6| 5| 5| 7| 7| 7| 6| 6| 5| 5| 7| 6| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 2| 2| 3| 8| 9| 0| 8| 7| 5| 3| 3| 3| 8| 1| 9| 7| 3| 5| 3|             
                                           | 0| 0| 0| 0| 0| 0| 0| 3| 0| 8| 4| 7| 9| 4| 9| 0| 0| 0| 8| 2| 9| 3| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    15000 PP                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    M                                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Leukemia Mononuclear                 |                X  X  X     X                             X               |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Leukemia Lymphocytic        |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Fibrous Histiocytoma, Metastatic,    |                                                                          |             
           Skeletal Muscle                 |                                                                          |             
      Leukemia Mononuclear                 |                   X  X     X                             X  X            |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | I  M  +  +  +  +  +  +  +  +  M  +  +  +  M  +  I  M  +  M  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X     X     X                                             |             
      Pheochromocytoma Malignant           |                                                                          |             
      Pheochromocytoma Benign              |          X              X                                                |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M  +  +  +  +  M  +  M  M  M  +  +  +  +  +  +  +  M  M  M  M  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               | X  X  X  X     X  X     X  X  X     X  X     X  X  X        X  X         |             
      Pars Distalis, Carcinoma             |                                                       X           X      |             
      Pars Distalis, Carcinoma, Metastatic,|                                                                          |             
           Zymbal's Gland                  |                                                                          |             
      Pars Distalis, Leukemia Mononuclear  |                            X                             X               |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      C-Cell, Adenoma                      |                                                                   X      |             
      C-Cell, Carcinoma                    |                                                                          |             
      Follicular Cell, Carcinoma           |                                  X                                X      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  I  +  +  M  M  +  +  +  +  +  M  +  +  M  +  +|             
      Adenoma                              |                   X                          X                          X|             
      Carcinoma                            |                                                    X                     |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granulosa Cell Tumor Malignant       |             X                                                            |             
      Leukemia Mononuclear                 |                            X                             X  X            |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                            X                             X               |             
      Polyp Stromal                        | X                       X     X                                X         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                          X               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  12                                                               
NTP Experiment-Test: 05078-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 05/05/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:10:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 5| 7| 6| 5| 5| 7| 7| 7| 6| 6| 5| 5| 7| 6| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 2| 2| 3| 8| 9| 0| 8| 7| 5| 3| 3| 3| 8| 1| 9| 7| 3| 5| 3|             
                                           | 0| 0| 0| 0| 0| 0| 0| 3| 0| 8| 4| 7| 9| 4| 9| 0| 0| 0| 8| 2| 9| 3| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    15000 PP                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    M                                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesenteric, Leukemia Mononuclear     |                                                          X               |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Fibrous Histiocytoma, Metastatic,    |                                                                          |             
           Uncertain Primary Site          |                                           X                              |             
      Fibrous Histiocytoma, Metastatic,    |                                                                          |             
           Skeletal Muscle                 |                                                                          |             
      Leukemia Mononuclear                 |             X  X  X  X     X     X                       X               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Leukemia Lymphocytic                 |                                                                          |             
      Leukemia Mononuclear                 |    X        X  X  X        X                             X               |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Histiocytoma, Metastatic     |                                           X                              |             
      Leukemia Mononuclear                 | X  X  X  X  X  X  X  X     X     X                 X     X  X     X     X|             
                                            __________________________________________________________________________|             
   Thymus                                  | M  M  +  +  +  +  +  +  M  +  +  M  +  +  M  +  +  M  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                   X        X                                             |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma                       |                                                                          |             
      Adenoma                              |                                                    X                     |             
      Fibroadenoma                         |                   X                    X           X              X  X   |             
      Fibroadenoma, Multiple               |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Basal Cell Carcinoma                 |                         X                                                |             
      Subcutaneous Tissue, Fibroma         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Histiocytoma, Metastatic,    |                                                                          |             
           Skeletal Muscle                 |                                                                          |             
      Periosteum, Leukemia Mononuclear     |                X  X        X                                             |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Fibrous Histiocytoma                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Astrocytoma Malignant                |                                                                      X   |             
      Carcinoma, Metastatic, Pituitary     |                                                                          |             
          Gland                            |                                                       X                  |             
      Leukemia Mononuclear                 |                                                          X               |             
      Meninges, Carcinoma, Metastatic,     |                                                                          |             
           Zymbal's Gland                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  13                                                               
NTP Experiment-Test: 05078-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 05/05/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:10:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 5| 7| 6| 5| 5| 7| 7| 7| 6| 6| 5| 5| 7| 6| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 2| 2| 3| 8| 9| 0| 8| 7| 5| 3| 3| 3| 8| 1| 9| 7| 3| 5| 3|             
                                           | 0| 0| 0| 0| 0| 0| 0| 3| 0| 8| 4| 7| 9| 4| 9| 0| 0| 0| 8| 2| 9| 3| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    15000 PP                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    M                                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Leukemia Lymphocytic                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basal Cell Carcinoma, Metastatic,    |                                                                          |             
           Skin                            |                         X                                                |             
      Fibrous Histiocytoma, Metastatic,    |                                                                          |             
           Uncertain Primary Site          |                                           X                              |             
      Fibrous Histiocytoma, Metastatic,    |                                                                          |             
           Skeletal Muscle                 |                                                                          |             
      Leukemia Mononuclear                 |       X     X     X  X     X     X                 X     X  X           X|             
      Sarcoma, Metastatic, Ear             |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Lymphocytic                 |                                                                          |             
      Leukemia Mononuclear                 |                            X                                             |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Leukemia Lymphocytic                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
      Sarcoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     | +  +                                                     +               |             
      Leukemia Mononuclear                 |                                                          X               |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |    +                                                                     |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                            +                                             |             
      Adenoma                              |                            X                                             |             
      Carcinoma                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Histiocytoma, Metastatic,    |                                                                          |             
           Uncertain Primary Site          |                                           X                              |             
      Leukemia Lymphocytic                 |                                                                          |             
      Leukemia Mononuclear                 |                X  X  X     X                             X  X            |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Leukemia Mononuclear                 |                   X        X                             X               |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Lymphocytic                 |                                                                          |             
      Leukemia Mononuclear                 | X  X  X  X  X  X  X  X     X     X              X  X     X  X     X     X|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  14                                                               
NTP Experiment-Test: 05078-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 05/05/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:10:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 6| 5| 7| 7| 6| 7| 6| 6| 5| 6| 7| 7| 7| 5| 7| 4| 3| 6| 7| 7| 7| 5| 5|            |
                             DAY ON TEST   | 4| 3| 0| 7| 3| 3| 7| 3| 2| 7| 8| 4| 3| 3| 3| 3| 3| 9| 6| 2| 3| 1| 3| 4| 6|            |
                                           | 5| 0| 8| 3| 0| 0| 9| 0| 2| 2| 8| 3| 0| 0| 0| 5| 0| 0| 4| 9| 0| 4| 0| 6| 3|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|     A      |
    15000 PP                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|     L      |
    M                                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  43        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrous Histiocytoma, Metastatic,    |                                                                          |            |
           Uncertain Primary Site          |                                                                          |          1 |
      Fibrous Histiocytoma, Metastatic,    |                                                                          |            |
           Skeletal Muscle                 |       X                                                                  |          1 |
      Leukemia Lymphocytic                 |    X                                                                     |          1 |
      Leukemia Mononuclear                 |             X  X           X     X        X  X           X  X           X|         25 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                    +        +            |   2        |
      Schwannoma Malignant, Metastatic,    |                                                                          |            |
           Stomach                         |                                                    X                     |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrous Histiocytoma, Metastatic,    |                                                                          |            |
           Uncertain Primary Site          |                                                                          |          1 |
      Leukemia Mononuclear                 |                            X                                             |          4 |
      Schwannoma Malignant, Metastatic,    |                                                                          |            |
           Stomach                         |                                                    X                     |          1 |
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                                             +            |   2        |
      Palate, Squamous Cell Papilloma      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Schwannoma Malignant                 |                                                    X                     |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
      Squamous Cell Papilloma              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  15                                                               
NTP Experiment-Test: 05078-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 05/05/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:10:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 6| 5| 7| 7| 6| 7| 6| 6| 5| 6| 7| 7| 7| 5| 7| 4| 3| 6| 7| 7| 7| 5| 5|            |
                             DAY ON TEST   | 4| 3| 0| 7| 3| 3| 7| 3| 2| 7| 8| 4| 3| 3| 3| 3| 3| 9| 6| 2| 3| 1| 3| 4| 6|            |
                                           | 5| 0| 8| 3| 0| 0| 9| 0| 2| 2| 8| 3| 0| 0| 0| 5| 0| 0| 4| 9| 0| 4| 0| 6| 3|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|     A      |
    15000 PP                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|     L      |
    M                                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrous Histiocytoma, Metastatic,    |                                                                          |            |
           Uncertain Primary Site          |                                                                          |          1 |
      Leukemia Lymphocytic                 |    X                                                                     |          1 |
      Leukemia Mononuclear                 |                            X     X           X                           |          8 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Capsule, Leukemia Lymphocytic        |    X                                                                     |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenoma                              |             X                                                            |          1 |
      Fibrous Histiocytoma, Metastatic,    |                                                                          |            |
           Skeletal Muscle                 |       X                                                                  |          1 |
      Leukemia Mononuclear                 |                                  X           X           X               |          8 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  I  +  +  +  +  +  +  M  +|  40        |
      Leukemia Mononuclear                 |                            X     X           X                           |          6 |
      Pheochromocytoma Malignant           |                                                             X            |          1 |
      Pheochromocytoma Benign              |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  M  +  +  +  +  +  M  M  M  +  +  +  I  M  +  M  +  +  M  M  +  +  +|  31        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Adenoma               |    X  X           X     X  X  X  X     X        X  X        X     X  X  X|         30 |
      Pars Distalis, Carcinoma             |                                                          X               |          3 |
      Pars Distalis, Carcinoma, Metastatic,|                                                                          |            |
           Zymbal's Gland                  |                         X                                                |          1 |
      Pars Distalis, Leukemia Mononuclear  |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      C-Cell, Adenoma                      |                                           X                              |          2 |
      C-Cell, Carcinoma                    |                                  X                                       |          1 |
      Follicular Cell, Carcinoma           |             X                                                            |          3 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  43        |
      Adenoma                              |                            X                                             |          4 |
      Carcinoma                            |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  16                                                               
NTP Experiment-Test: 05078-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 05/05/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:10:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 6| 5| 7| 7| 6| 7| 6| 6| 5| 6| 7| 7| 7| 5| 7| 4| 3| 6| 7| 7| 7| 5| 5|            |
                             DAY ON TEST   | 4| 3| 0| 7| 3| 3| 7| 3| 2| 7| 8| 4| 3| 3| 3| 3| 3| 9| 6| 2| 3| 1| 3| 4| 6|            |
                                           | 5| 0| 8| 3| 0| 0| 9| 0| 2| 2| 8| 3| 0| 0| 0| 5| 0| 0| 4| 9| 0| 4| 0| 6| 3|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|     A      |
    15000 PP                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|     L      |
    M                                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Granulosa Cell Tumor Malignant       |                                                                          |          1 |
      Leukemia Mononuclear                 |                            X     X           X                           |          6 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                                          |          2 |
      Polyp Stromal                        |                   X              X              X                        |          7 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|  49        |
      Mesenteric, Leukemia Mononuclear     |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|  47        |
      Fibrous Histiocytoma, Metastatic,    |                                                                          |            |
           Uncertain Primary Site          |                                                                          |          1 |
      Fibrous Histiocytoma, Metastatic,    |                                                                          |            |
           Skeletal Muscle                 |       X                                                                  |          1 |
      Leukemia Mononuclear                 |                            X     X                       X              X|         11 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  M  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  M  +  +  +  M|  43        |
      Leukemia Lymphocytic                 |    X                                                                     |          1 |
      Leukemia Mononuclear                 |                            X                 X                           |          8 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrous Histiocytoma, Metastatic     |                                                                          |          1 |
      Leukemia Mononuclear                 |             X  X           X     X           X           X  X           X|         23 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  M  M  M  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|  39        |
      Leukemia Mononuclear                 |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenocarcinoma                       |                                           X                              |          1 |
      Adenoma                              |                                                                          |          1 |
      Fibroadenoma                         |                      X        X                                X         |          8 |
      Fibroadenoma, Multiple               |                                                                X         |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Basal Cell Carcinoma                 |                                                                          |          1 |
      Subcutaneous Tissue, Fibroma         |                                     X                                    |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  17                                                               
NTP Experiment-Test: 05078-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 05/05/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:10:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 6| 5| 7| 7| 6| 7| 6| 6| 5| 6| 7| 7| 7| 5| 7| 4| 3| 6| 7| 7| 7| 5| 5|            |
                             DAY ON TEST   | 4| 3| 0| 7| 3| 3| 7| 3| 2| 7| 8| 4| 3| 3| 3| 3| 3| 9| 6| 2| 3| 1| 3| 4| 6|            |
                                           | 5| 0| 8| 3| 0| 0| 9| 0| 2| 2| 8| 3| 0| 0| 0| 5| 0| 0| 4| 9| 0| 4| 0| 6| 3|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|     A      |
    15000 PP                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|     L      |
    M                                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
      Fibrous Histiocytoma, Metastatic,    |                                                                          |            |
           Skeletal Muscle                 |       X                                                                  |          1 |
      Periosteum, Leukemia Mononuclear     |                                           X                              |          4 |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |       +                                                                  |   1        |
      Fibrous Histiocytoma                 |       X                                                                  |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Astrocytoma Malignant                |                                                       X        X         |          3 |
      Carcinoma, Metastatic, Pituitary     |                                                                          |            |
          Gland                            |                                                          X               |          2 |
      Leukemia Mononuclear                 |                                  X           X                           |          3 |
      Meninges, Carcinoma, Metastatic,     |                                                                          |            |
           Zymbal's Gland                  |                         X                                                |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Lymphocytic                 |    X                                                                     |          1 |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basal Cell Carcinoma, Metastatic,    |                                                                          |            |
           Skin                            |                                                                          |          1 |
      Fibrous Histiocytoma, Metastatic,    |                                                                          |            |
           Uncertain Primary Site          |                                                                          |          1 |
      Fibrous Histiocytoma, Metastatic,    |                                                                          |            |
           Skeletal Muscle                 |       X                                                                  |          1 |
      Leukemia Mononuclear                 |             X              X     X           X           X              X|         16 |
      Sarcoma, Metastatic, Ear             |          X                                                               |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Lymphocytic                 |    X                                                                     |          1 |
      Leukemia Mononuclear                 |                                  X           X                           |          3 |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Lymphocytic                 |    X                                                                     |          1 |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |          +              +                                                |   2        |
      Sarcoma                              |          X                                                               |          1 |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                 +                    +   |   5        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  18                                                               
NTP Experiment-Test: 05078-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 05/05/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:10:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 6| 5| 7| 7| 6| 7| 6| 6| 5| 6| 7| 7| 7| 5| 7| 4| 3| 6| 7| 7| 7| 5| 5|            |
                             DAY ON TEST   | 4| 3| 0| 7| 3| 3| 7| 3| 2| 7| 8| 4| 3| 3| 3| 3| 3| 9| 6| 2| 3| 1| 3| 4| 6|            |
                                           | 5| 0| 8| 3| 0| 0| 9| 0| 2| 2| 8| 3| 0| 0| 0| 5| 0| 0| 4| 9| 0| 4| 0| 6| 3|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|     A      |
    15000 PP                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|     L      |
    M                                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                         +                                                |   2        |
      Adenoma                              |                                                                          |          1 |
      Carcinoma                            |                         X                                                |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrous Histiocytoma, Metastatic,    |                                                                          |            |
           Uncertain Primary Site          |                                                                          |          1 |
      Leukemia Lymphocytic                 |    X                                                                     |          1 |
      Leukemia Mononuclear                 |                            X                 X                           |          8 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |                                                                          |          3 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Lymphocytic                 |    X                                                                     |          1 |
      Leukemia Mononuclear                 |             X  X           X     X        X  X           X  X           X|         25 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  19                                                               
NTP Experiment-Test: 05078-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 05/05/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:10:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 6| 6| 6| 7| 6| 5| 6| 4| 6| 7| 6| 6| 6| 5| 7| 6| 7| 7| 7| 6| 5| 7|             
                             DAY ON TEST   | 8| 9| 3| 9| 8| 6| 3| 9| 7| 7| 8| 5| 3| 4| 7| 5| 7| 3| 9| 3| 3| 3| 6| 2| 2|             
                                           | 2| 6| 0| 6| 2| 8| 0| 8| 0| 1| 5| 8| 0| 5| 5| 4| 0| 0| 9| 0| 0| 0| 5| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  M  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma             |                            X                                             |             
      Leukemia Mononuclear                 | X  X  X  X  X  X  X     X  X     X  X  X     X  X  X     X              X|             
      Lymphoma Malignant Histiocytic       |                                                                      X   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                   +      |             
      Mesothelioma Malignant, Metastatic,  |                                                                          |             
           Testes                          |                                                                   X      |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X                       X  X        X                           |             
      Mesothelioma Malignant               |                                                                          |             
      Mesothelioma Malignant, Metastatic,  |                                                                          |             
           Testes                          |                                                                   X      |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  I  +  +  +  +|             
      Squamous Cell Papilloma              |                                                                X         |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                         +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X  X  X  X        X  X     X  X        X                          X|             
      Schwannoma NOS                       |             X                                                            |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Leukemia Mononuclear                 |    X     X  X  X        X  X     X     X     X  X                       X|             
      Lymphoma Malignant Histiocytic       |                                                                      X   |             
      Mesothelioma Malignant, Metastatic,  |                                                                          |             
           Testes                          |                                                                   X      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  M  +  +  +  M  +  +  M  +  +  M  M  M  +  +  +  +  +  +  +  M  +|             
      Leukemia Mononuclear                 |    X        X  X        X        X                                      X|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  20                                                               
NTP Experiment-Test: 05078-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 05/05/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:10:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 6| 6| 6| 7| 6| 5| 6| 4| 6| 7| 6| 6| 6| 5| 7| 6| 7| 7| 7| 6| 5| 7|             
                             DAY ON TEST   | 8| 9| 3| 9| 8| 6| 3| 9| 7| 7| 8| 5| 3| 4| 7| 5| 7| 3| 9| 3| 3| 3| 6| 2| 2|             
                                           | 2| 6| 0| 6| 2| 8| 0| 8| 0| 1| 5| 8| 0| 5| 5| 4| 0| 0| 9| 0| 0| 0| 5| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pheochromocytoma Benign              |       X                             X                       X            |             
      Bilateral, Pheochromocytoma Benign   |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Adenoma                              | X                       X                                               X|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  M  M  M  +  +  M  M  +  +  M  M  M  M  +  +  +  +  +  +  M  +  +  +  +|             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X  X  X        X                                                |             
      Pars Distalis, Adenoma               | X     X  X        X        X  X  X  X  X  X  X     X  X        X     X   |             
      Pars Distalis, Carcinoma             |                                                                          |             
      Pars Distalis, Leukemia Mononuclear  |                                        X     X  X                        |             
      Pars Intermedia, Adenoma             |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      |                                                       X        X         |             
      C-Cell, Adenoma, Multiple            | X                                                                        |             
      C-Cell, Carcinoma                    |                                              X                           |             
      Follicular Cell, Carcinoma           |                   X                                                      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                       +                  |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  M  +  M  M  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  I  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Carcinoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |          +     +                 +                                       |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X  X                             X                          X|             
      Mesothelioma Malignant               |                                                                   X      |             
      Bilateral, Interstitial Cell, Adenoma|    X  X     X  X  X              X  X              X        X           X|             
      Interstitial Cell, Adenoma           |                         X                    X                 X  X      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                              X  X                        |             
      Lymphoma Malignant Histiocytic       |                                                                      X   |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesenteric, Leukemia Mononuclear     |                                        X        X                        |             
      Pancreatic, Leukemia Mononuclear     |                            X                                             |             
      Renal, Leukemia Mononuclear          |                            X                    X                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X  X  X  X        X  X        X  X        X        X              X|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  21                                                               
NTP Experiment-Test: 05078-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 05/05/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:10:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 6| 6| 6| 7| 6| 5| 6| 4| 6| 7| 6| 6| 6| 5| 7| 6| 7| 7| 7| 6| 5| 7|             
                             DAY ON TEST   | 8| 9| 3| 9| 8| 6| 3| 9| 7| 7| 8| 5| 3| 4| 7| 5| 7| 3| 9| 3| 3| 3| 6| 2| 2|             
                                           | 2| 6| 0| 6| 2| 8| 0| 8| 0| 1| 5| 8| 0| 5| 5| 4| 0| 0| 9| 0| 0| 0| 5| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  I  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X  X  X  X  X           X        X  X     X           X               |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangioma                           |                                                                          |             
      Leukemia Mononuclear                 | X  X  X  X  X  X  X     X  X     X  X  X     X  X  X     X              X|             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +  M  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  M  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X                                X                        |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  +  M  M  M  +  M  M  M  +  +  M  M  M  M  M  M  M  M  M  M  M  M  +|             
      Fibroadenoma                         |                               X                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Keratoacanthoma                      | X                                                                        |             
      Subcutaneous Tissue, Fibroma         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granular Cell Tumor Malignant        |                                                                          |             
      Leukemia Mononuclear                 |                X                             X                           |             
      Oligodendroglioma Malignant          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X  X  X  X  X  X        X  X     X  X  X     X  X        X              X|             
      Mediastinum, Mesothelioma Benign     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X  X  X                 X           X                           |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |    M                       +                                             |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                         +|             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
      Carcinoma                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X     X  X  X        X              X     X  X        X              X|             
      Lipoma, Moderate                     |                                                 X                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  22                                                               
NTP Experiment-Test: 05078-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 05/05/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:10:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 6| 6| 6| 7| 6| 5| 6| 4| 6| 7| 6| 6| 6| 5| 7| 6| 7| 7| 7| 6| 5| 7|             
                             DAY ON TEST   | 8| 9| 3| 9| 8| 6| 3| 9| 7| 7| 8| 5| 3| 4| 7| 5| 7| 3| 9| 3| 3| 3| 6| 2| 2|             
                                           | 2| 6| 0| 6| 2| 8| 0| 8| 0| 1| 5| 8| 0| 5| 5| 4| 0| 0| 9| 0| 0| 0| 5| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant Histiocytic       |                                                                      X   |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                           +                              |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                  X                                       |             
      Mesothelioma Malignant, Metastatic,  |                                                                          |             
           Testes                          |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X  X  X  X  X  X  X     X  X     X  X  X     X  X  X     X              X|             
      Lymphoma Malignant Histiocytic       |                                                                      X   |             
      Mesothelioma Benign                  |                                                                          |             
      Mesothelioma Malignant               |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  23                                                               
NTP Experiment-Test: 05078-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 05/05/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:10:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 6| 7| 6| 7| 7| 6| 5| 7| 6| 7| 5| 6| 7| 5| 6| 5| 5| 5| 7| 5| 6|            |
                             DAY ON TEST   | 3| 2| 3| 1| 7| 3| 1| 3| 3| 8| 0| 3| 4| 3| 1| 5| 3| 4| 9| 6| 4| 8| 3| 1| 4|            |
                                           | 0| 6| 0| 7| 2| 0| 1| 0| 0| 9| 0| 0| 6| 0| 2| 4| 0| 2| 2| 7| 5| 7| 0| 7| 1|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     A      |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hepatocellular Carcinoma             |                                                                          |          1 |
      Leukemia Mononuclear                 | X     X     X  X  X  X  X  X           X     X     X        X        X  X|         31 |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
      Mesothelioma Malignant, Metastatic,  |                                                                          |            |
           Testes                          |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                                          |          4 |
      Mesothelioma Malignant               |                X                                                         |          1 |
      Mesothelioma Malignant, Metastatic,  |                                                                          |            |
           Testes                          |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                           +           +                  |   2        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Squamous Cell Papilloma              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Tooth                                   | +                                                                       +|   3        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                   X                                                  X   |         12 |
      Schwannoma NOS                       |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenoma                              | X                                                                        |          1 |
      Leukemia Mononuclear                 | X                 X                                                  X   |         14 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  24                                                               
NTP Experiment-Test: 05078-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 05/05/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:10:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 6| 7| 6| 7| 7| 6| 5| 7| 6| 7| 5| 6| 7| 5| 6| 5| 5| 5| 7| 5| 6|            |
                             DAY ON TEST   | 3| 2| 3| 1| 7| 3| 1| 3| 3| 8| 0| 3| 4| 3| 1| 5| 3| 4| 9| 6| 4| 8| 3| 1| 4|            |
                                           | 0| 6| 0| 7| 2| 0| 1| 0| 0| 9| 0| 0| 6| 0| 2| 4| 0| 2| 2| 7| 5| 7| 0| 7| 1|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     A      |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Mesothelioma Malignant, Metastatic,  |                                                                          |            |
           Testes                          |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  I  +  +  +  M  I  +  +  M  +  M  +  M  M  +  +  +  +  +  +  +  +  +  +|  36        |
      Leukemia Mononuclear                 | X                                                                    X   |          8 |
      Pheochromocytoma Benign              |                         X     X              X                    X      |          7 |
      Bilateral, Pheochromocytoma Benign   |                      X                                                   |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  48        |
      Adenoma                              |             X  X                       X                                 |          6 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  M  M  +  +  M  +  +  +  M  +  +  +  +  +  M  +  +  +  M  M  +  +  +|  31        |
      Adenoma                              |                                                                         X|          1 |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 | X                 X                                                  X   |          7 |
      Pars Distalis, Adenoma               | X     X  X        X  X     X  X     X  X     X        X  X  X     X  X  X|         31 |
      Pars Distalis, Carcinoma             |                                  X                                       |          1 |
      Pars Distalis, Leukemia Mononuclear  |                                                                          |          3 |
      Pars Intermedia, Adenoma             |                                                          X               |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      C-Cell, Adenoma                      |                X                 X     X                       X         |          6 |
      C-Cell, Adenoma, Multiple            |                                                                          |          1 |
      C-Cell, Carcinoma                    |       X                                                                  |          2 |
      Follicular Cell, Carcinoma           |       X                                                                  |          2 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  I  +  +  M  +  +  M  +  M  M  +  +  +  +  M  +  M  +  M  +  +  +  +|  37        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  47        |
      Adenoma                              |                                                 X                        |          1 |
      Carcinoma                            |                                                       X                  |          1 |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |          +     +  +  +                                                   |   7        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                                          |          4 |
      Mesothelioma Malignant               |                                                                          |          1 |
      Bilateral, Interstitial Cell, Adenoma|       X     X           X  X  X                 X              X  X     X|         19 |
      Interstitial Cell, Adenoma           |          X     X  X              X     X              X                  |         10 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  25                                                               
NTP Experiment-Test: 05078-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 05/05/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:10:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 6| 7| 6| 7| 7| 6| 5| 7| 6| 7| 5| 6| 7| 5| 6| 5| 5| 5| 7| 5| 6|            |
                             DAY ON TEST   | 3| 2| 3| 1| 7| 3| 1| 3| 3| 8| 0| 3| 4| 3| 1| 5| 3| 4| 9| 6| 4| 8| 3| 1| 4|            |
                                           | 0| 6| 0| 7| 2| 0| 1| 0| 0| 9| 0| 0| 6| 0| 2| 4| 0| 2| 2| 7| 5| 7| 0| 7| 1|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     A      |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                                          |          2 |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Mesenteric, Leukemia Mononuclear     |                                                                          |          2 |
      Pancreatic, Leukemia Mononuclear     |                                                                          |          1 |
      Renal, Leukemia Mononuclear          |                                                                      X   |          3 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +  M  +  +  +  +  M  +  +  M  +  M  +  +  +  +  M  +  +  +  +|  42        |
      Leukemia Mononuclear                 | X                 X  X                                               X   |         15 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  45        |
      Leukemia Mononuclear                 | X                 X  X                                               X   |         14 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemangioma                           |                      X                                                   |          1 |
      Leukemia Mononuclear                 | X     X        X  X  X  X  X           X     X  X  X                 X  X|         30 |
      Mesothelioma Malignant               |                X                                                         |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  M  +  +  +  M  +  +  +  +  +  M  +  +  M  M  +  +  +  +  +  M  +  +|  39        |
      Leukemia Mononuclear                 | X                                                                        |          3 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  +  M  M  M  M  M  M  M  M  M  +  M  M  M  +  +  M  M  M  M  +  +  +  +|  13        |
      Fibroadenoma                         |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Keratoacanthoma                      |                                        X              X           X      |          4 |
      Subcutaneous Tissue, Fibroma         |    X                                                                     |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Granular Cell Tumor Malignant        |                            X                                             |          1 |
      Leukemia Mononuclear                 |                                                                          |          2 |
      Oligodendroglioma Malignant          |                                                          X               |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 | X              X  X  X     X                 X     X           X     X   |         24 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  26                                                               
NTP Experiment-Test: 05078-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 05/05/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:10:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 6| 7| 6| 7| 7| 6| 5| 7| 6| 7| 5| 6| 7| 5| 6| 5| 5| 5| 7| 5| 6|            |
                             DAY ON TEST   | 3| 2| 3| 1| 7| 3| 1| 3| 3| 8| 0| 3| 4| 3| 1| 5| 3| 4| 9| 6| 4| 8| 3| 1| 4|            |
                                           | 0| 6| 0| 7| 2| 0| 1| 0| 0| 9| 0| 0| 6| 0| 2| 4| 0| 2| 2| 7| 5| 7| 0| 7| 1|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     A      |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Mediastinum, Mesothelioma Benign     |                                                 X                        |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                   X                                                      |          6 |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                           +                              |   1        |
      Carcinoma                            |                                           X                              |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 | X                 X                                                      |         12 |
      Lipoma, Moderate                     |                                                                          |          1 |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urethra                                 |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Mesothelioma Malignant, Metastatic,  |                                                                          |            |
           Testes                          |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 | X     X     X  X  X  X  X  X           X     X  X  X        X  X     X  X|         33 |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Mesothelioma Benign                  |                                                 X                        |          1 |
      Mesothelioma Malignant               |                X                                                         |          2 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  27                                                               
NTP Experiment-Test: 05078-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 05/05/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:10:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 6| 5| 7| 7| 7| 7| 6| 6| 7| 7| 6| 5| 7| 6| 5| 6| 6| 5| 7| 6| 7| 5| 7|             
                             DAY ON TEST   | 2| 7| 7| 5| 2| 1| 2| 0| 2| 6| 2| 2| 8| 8| 0| 4| 8| 2| 1| 4| 2| 3| 1| 1| 0|             
                                           | 9| 9| 1| 2| 9| 6| 9| 9| 6| 4| 9| 9| 9| 1| 1| 6| 7| 1| 1| 9| 7| 3| 3| 9| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    15000 PP                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    M                                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +     +  A|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +     +  A|             
      Mesothelioma Malignant, Metastatic,  |                                                                          |             
           Testes                          |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  A  A  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  A  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  M  A  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  A|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X     X  X     X     X  X  X  X  X           X  X     X  X        X|             
      Mesothelioma Malignant, Metastatic,  |                                                                          |             
           Testes                          |                                                                          |             
      Neoplastic Nodule, Multiple          |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Mesothelioma Malignant, Metastatic,  |                                                                          |             
           Testes                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Leukemia Mononuclear                 |                      X           X                                       |             
      Mesothelioma Malignant, Metastatic,  |                                                                          |             
           Testes                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                           +                              |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cortex, Leukemia Mononuclear         |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Serosa, Mesothelioma Malignant,      |                                                                          |             
          Metastatic, Testes               |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                            X     X     X           X                    X|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X  X     X     X     X                 X           X        X|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X              X     X                             X        X|             
      Pheochromocytoma Malignant           |                                                                          |             
      Pheochromocytoma Benign              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  28                                                               
NTP Experiment-Test: 05078-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 05/05/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:10:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 6| 5| 7| 7| 7| 7| 6| 6| 7| 7| 6| 5| 7| 6| 5| 6| 6| 5| 7| 6| 7| 5| 7|             
                             DAY ON TEST   | 2| 7| 7| 5| 2| 1| 2| 0| 2| 6| 2| 2| 8| 8| 0| 4| 8| 2| 1| 4| 2| 3| 1| 1| 0|             
                                           | 9| 9| 1| 2| 9| 6| 9| 9| 6| 4| 9| 9| 9| 1| 1| 6| 7| 1| 1| 9| 7| 3| 3| 9| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    15000 PP                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    M                                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Bilateral, Pheochromocytoma Benign   |                            X     X                                X      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Adenoma                              |                                           X                              |             
      Adenoma, Multiple                    |             X                                                            |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                      X     X     X                 X                     |             
      Pars Distalis, Adenoma               | X     X  X  X           X     X     X        X  X  X        X  X  X  X  X|             
      Pars Distalis, Leukemia Mononuclear  |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  A  +  +  +  +|             
      C-Cell, Adenoma                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |       +                                                                  |             
      Chordoma                             |       X                                                                  |             
      Leukemia Mononuclear                 |                                                                          |             
      Sarcoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  M  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Carcinoma                            |                                                                X         |             
                                            __________________________________________________________________________|             
   Prostate                                | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Sarcoma, Metastatic, Uncertain       |                                                                          |             
          Primary Site                     |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |    +           +                                +     +                  |             
      Sarcoma, Metastatic, Uncertain       |                                                                          |             
          Primary Site                     |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                      X     X                                             |             
      Bilateral, Interstitial Cell, Adenoma|             X     X              X     X  X                              |             
      Interstitial Cell, Adenoma           |    X  X  X     X     X     X  X              X        X                  |             
      Tunic, Mesothelioma Malignant        |                         X                                                |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Leukemia Mononuclear                 |                            X           X                                 |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Sarcoma, Metastatic, Uncertain       |                                                                          |             
          Primary Site                     |                                                                          |             
      Mesenteric, Leukemia Mononuclear     |                            X                                             |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  29                                                               
NTP Experiment-Test: 05078-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 05/05/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:10:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 6| 5| 7| 7| 7| 7| 6| 6| 7| 7| 6| 5| 7| 6| 5| 6| 6| 5| 7| 6| 7| 5| 7|             
                             DAY ON TEST   | 2| 7| 7| 5| 2| 1| 2| 0| 2| 6| 2| 2| 8| 8| 0| 4| 8| 2| 1| 4| 2| 3| 1| 1| 0|             
                                           | 9| 9| 1| 2| 9| 6| 9| 9| 6| 4| 9| 9| 9| 1| 1| 6| 7| 1| 1| 9| 7| 3| 3| 9| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    15000 PP                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    M                                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Leukemia Mononuclear                 |             X  X           X     X                                       |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  M  +  +  +  +  +  +  +  I  +|             
      Leukemia Mononuclear                 |             X        X           X                                       |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X  X  X  X  X  X     X  X  X  X  X           X  X     X  X        X|             
      Mesothelioma Malignant, Metastatic,  |                                                                          |             
           Testes                          |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  M|             
      Leukemia Mononuclear                 |                                  X                                       |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  +  M  M  M  M  M  M  M  +  M  M  +  +  M  M  +  +  M  M  +  +  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Basal Cell Carcinoma                 |                   X                                                      |             
      Keratoacanthoma                      |                                                                          |             
      Squamous Cell Carcinoma              |                                                                          |             
      Trichoepithelioma                    |                X                                                         |             
      Lip, Squamous Cell Carcinoma         |                                           X                              |             
      Sebaceous Gland, Adenoma             |                                                                          |             
      Subcutaneous Tissue, Fibroma         |          X                                            X                  |             
      Subcutaneous Tissue, Fibrous         |                                                                          |             
          Histiocytoma                     |                                                                          |             
      Subcutaneous Tissue, Lipoma          |                                                                          |             
      Subcutaneous Tissue,                 |                                                                          |             
          Neurofibrosarcoma                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Astrocytoma Malignant                |                                                                          |             
      Leukemia Mononuclear                 |                            X                       X                     |             
      Oligodendroglioma Benign             |                                                                X         |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  I  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X  X     X     X     X  X  X           X        X  X        X|             
      Sarcoma, Metastatic                  |                                                                          |             
      Squamous Cell Carcinoma              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  30                                                               
NTP Experiment-Test: 05078-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 05/05/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:10:54  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 6| 5| 7| 7| 7| 7| 6| 6| 7| 7| 6| 5| 7| 6| 5| 6| 6| 5| 7| 6| 7| 5| 7|             
                             DAY ON TEST   | 2| 7| 7| 5| 2| 1| 2| 0| 2| 6| 2| 2| 8| 8| 0| 4| 8| 2| 1| 4| 2| 3| 1| 1| 0|             
                                           | 9| 9| 1| 2| 9| 6| 9| 9| 6| 4| 9| 9| 9| 1| 1| 6| 7| 1| 1| 9| 7| 3| 3| 9| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    15000 PP                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    M                                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Leukemia Mononuclear                 |                X     X     X                                             |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     | +                                   +     +                          +   |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X  X     X     X     X                 X                    X|             
      Renal Tubule, Carcinoma              |                      X                                                   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X              X     X                                       |             
      Mesothelioma Malignant, Metastatic,  |                                                                          |             
           Testes                          |                                                                          |             
      Sarcoma, Metastatic, Uncertain       |                                                                          |             
          Primary Site                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X  X  X  X  X  X     X  X  X  X  X           X  X     X  X        X|             
      Mesothelioma Malignant               |                         X                                                |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  31                                                               
NTP Experiment-Test: 05078-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 05/05/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:10:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 7| 5| 6| 6| 7| 7| 7| 5| 7| 6| 7| 6| 6| 7| 5| 6| 6| 5| 4| 5| 6| 4|            |
                             DAY ON TEST   | 2| 1| 0| 0| 7| 7| 2| 2| 2| 2| 7| 0| 0| 1| 1| 7| 0| 2| 4| 2| 6| 3| 8| 0| 7|            |
                                           | 8| 4| 7| 0| 7| 8| 6| 9| 9| 9| 7| 4| 2| 7| 3| 8| 9| 6| 6| 6| 2| 7| 7| 8| 1|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     A      |
    15000 PP                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|     L      |
    M                                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +|  43        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  A  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +|  45        |
      Mesothelioma Malignant, Metastatic,  |                                                                          |            |
           Testes                          |                                                 X                        |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +|  43        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  A  +  +  +|  40        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 | X     X  X     X     X  X  X  X  X  X  X  X  X  X  X  X  X  X  X     X   |         34 |
      Mesothelioma Malignant, Metastatic,  |                                                                          |            |
           Testes                          |                                                 X                        |          1 |
      Neoplastic Nodule, Multiple          |                            X                                             |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                 +                        |   1        |
      Mesothelioma Malignant, Metastatic,  |                                                                          |            |
           Testes                          |                                                 X                        |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 | X     X                                         X              X     X   |          7 |
      Mesothelioma Malignant, Metastatic,  |                                                                          |            |
           Testes                          |                                                 X                        |          1 |
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cortex, Leukemia Mononuclear         |                                                                X         |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Serosa, Mesothelioma Malignant,      |                                                                          |            |
          Metastatic, Testes               |                               X                 X                        |          2 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 | X     X                 X     X     X     X           X        X     X   |         14 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  32                                                               
NTP Experiment-Test: 05078-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 05/05/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:10:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 7| 5| 6| 6| 7| 7| 7| 5| 7| 6| 7| 6| 6| 7| 5| 6| 6| 5| 4| 5| 6| 4|            |
                             DAY ON TEST   | 2| 1| 0| 0| 7| 7| 2| 2| 2| 2| 7| 0| 0| 1| 1| 7| 0| 2| 4| 2| 6| 3| 8| 0| 7|            |
                                           | 8| 4| 7| 0| 7| 8| 6| 9| 9| 9| 7| 4| 2| 7| 3| 8| 9| 6| 6| 6| 2| 7| 7| 8| 1|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     A      |
    15000 PP                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|     L      |
    M                                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Leukemia Mononuclear                 | X     X                 X     X                 X     X              X   |         15 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Leukemia Mononuclear                 | X                             X     X  X        X                        |         10 |
      Pheochromocytoma Malignant           |                                                                      X   |          1 |
      Pheochromocytoma Benign              |                                           X                 X            |          2 |
      Bilateral, Pheochromocytoma Benign   |                X     X     X                 X                           |          7 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  48        |
      Adenoma                              |                                  X                                       |          2 |
      Adenoma, Multiple                    |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  M  +  M|  41        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 | X                                                                    X   |          6 |
      Pars Distalis, Adenoma               |                X  X  X     X  X  X     X                 X  X     X      |         25 |
      Pars Distalis, Leukemia Mononuclear  |                                                                X         |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  47        |
      C-Cell, Adenoma                      |                                                 X                        |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                  +                             +        +|   4        |
      Chordoma                             |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                X         |          1 |
      Sarcoma                              |                                                                         X|          1 |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  M  M  +  +  I  +  +  +  +  +  +  +  +  +  M  +  +  +|  42        |
                                            __________________________________________________________________________|____________|
   Penis                                   |                                  +                                       |   1        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
      Adenoma                              |                                                 X                        |          1 |
      Carcinoma                            |                      X                                                   |          2 |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +|  48        |
      Sarcoma, Metastatic, Uncertain       |                                                                          |            |
          Primary Site                     |                                                                         X|          1 |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                                              +                          +|   6        |
      Sarcoma, Metastatic, Uncertain       |                                                                          |            |
          Primary Site                     |                                                                         X|          1 |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                                          |          2 |
      Bilateral, Interstitial Cell, Adenoma|          X                                      X                    X   |          8 |
      Interstitial Cell, Adenoma           | X           X           X  X  X  X     X              X                  |         17 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  33                                                               
NTP Experiment-Test: 05078-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 05/05/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:10:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 7| 5| 6| 6| 7| 7| 7| 5| 7| 6| 7| 6| 6| 7| 5| 6| 6| 5| 4| 5| 6| 4|            |
                             DAY ON TEST   | 2| 1| 0| 0| 7| 7| 2| 2| 2| 2| 7| 0| 0| 1| 1| 7| 0| 2| 4| 2| 6| 3| 8| 0| 7|            |
                                           | 8| 4| 7| 0| 7| 8| 6| 9| 9| 9| 7| 4| 2| 7| 3| 8| 9| 6| 6| 6| 2| 7| 7| 8| 1|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     A      |
    15000 PP                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|     L      |
    M                                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Tunic, Mesothelioma Malignant        |                               X                 X                        |          3 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                  +  +  +     +                           |   4        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Leukemia Mononuclear                 |       X                                      X  X     X              X   |          7 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Sarcoma, Metastatic, Uncertain       |                                                                          |            |
          Primary Site                     |                                                                         X|          1 |
      Mesenteric, Leukemia Mononuclear     |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Leukemia Mononuclear                 | X     X                             X  X        X     X        X     X   |         12 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  M  M  M  +  M  +  +  +  +  +  +  +  +  M  +  M  M  +  +  +  M|  38        |
      Leukemia Mononuclear                 |       X                       X                 X     X              X   |          8 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 | X     X  X     X     X  X     X  X  X  X  X  X  X  X  X  X  X  X     X   |         35 |
      Mesothelioma Malignant, Metastatic,  |                                                                          |            |
           Testes                          |                                                 X                        |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | I  +  M  +  +  M  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  41        |
      Leukemia Mononuclear                 |                                                       X                  |          2 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  +  +  M  M  M  M  M  M  M  M  M  +  +  M  M  M  M  M  M  +  M  +  M  M|  14        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +|  46        |
      Basal Cell Carcinoma                 | X                                            X                           |          3 |
      Keratoacanthoma                      | X              X                                                         |          2 |
      Squamous Cell Carcinoma              |             X                                                            |          1 |
      Trichoepithelioma                    |                                                                          |          1 |
      Lip, Squamous Cell Carcinoma         |                                                                          |          1 |
      Sebaceous Gland, Adenoma             |                                                 X                        |          1 |
      Subcutaneous Tissue, Fibroma         |                                                                          |          2 |
      Subcutaneous Tissue, Fibrous         |                                                                          |            |
          Histiocytoma                     |                         X                                                |          1 |
      Subcutaneous Tissue, Lipoma          |       X                                                                  |          1 |
      Subcutaneous Tissue,                 |                                                                          |            |
          Neurofibrosarcoma                |                X                                                         |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  34                                                               
NTP Experiment-Test: 05078-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 05/05/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:10:54  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 7| 5| 6| 6| 7| 7| 7| 5| 7| 6| 7| 6| 6| 7| 5| 6| 6| 5| 4| 5| 6| 4|            |
                             DAY ON TEST   | 2| 1| 0| 0| 7| 7| 2| 2| 2| 2| 7| 0| 0| 1| 1| 7| 0| 2| 4| 2| 6| 3| 8| 0| 7|            |
                                           | 8| 4| 7| 0| 7| 8| 6| 9| 9| 9| 7| 4| 2| 7| 3| 8| 9| 6| 6| 6| 2| 7| 7| 8| 1|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     A      |
    15000 PP                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|     L      |
    M                                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Astrocytoma Malignant                |                         X                                                |          1 |
      Leukemia Mononuclear                 |       X                                                        X         |          4 |
      Oligodendroglioma Benign             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                  +                                       |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  I  +  +  +  +  +  +|  44        |
      Leukemia Mononuclear                 |                X                                                         |          1 |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 | X     X  X           X  X     X  X  X  X     X     X  X  X  X  X     X   |         27 |
      Sarcoma, Metastatic                  |                                                                         X|          1 |
      Squamous Cell Carcinoma              |          X                                                               |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |                                                                X         |          4 |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                  +           +     +                     |   7        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |       X                 X     X     X  X              X              X   |         14 |
      Renal Tubule, Carcinoma              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |                                                       X                  |          4 |
      Mesothelioma Malignant, Metastatic,  |                                                                          |            |
           Testes                          |                                                 X                        |          1 |
      Sarcoma, Metastatic, Uncertain       |                                                                          |            |
          Primary Site                     |                                                                         X|          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 | X     X  X     X     X  X  X  X  X  X  X  X  X  X  X  X  X  X  X     X   |         36 |
      Mesothelioma Malignant               |                               X                 X                        |          3 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  35                                                               
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