TR 346 Rat Pathology Tables
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
ETHYL CHLORIDE
NTP Experiment-Test: 05078-01 Report: PEIRPT05
Study Type: CHRONIC Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:04:19
Facility: Battelle Northwest
Chemical CAS #: 75-00-3
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05078-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ETHYL CHLORIDE Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:04:19
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 15000 PP
M
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50
Early Deaths
Moribund Sacrifice 19 24
Natural Death 4
Survivors
Terminal Sacrifice 31 22
Animals Examined Microscopically 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (50) (48)
Sarcoma, Metastatic, Bone 1 (2%)
Intestine Large, Colon (50) (49)
Intestine Small, Ileum (47) (43)
Sarcoma, Metastatic, Tissue NOS 1 (2%)
Liver (50) (50)
Fibrous Histiocytoma, Metastatic, Uncertain
Primary Site 1 (2%)
Fibrous Histiocytoma, Metastatic, Skeletal
Muscle 1 (2%)
Hepatocellular Carcinoma 1 (2%)
Sarcoma, Metastatic, Bone 1 (2%)
Mesentery (1) (2)
Schwannoma Malignant, Metastatic, Stomach 1 (50%)
Pancreas (49) (50)
Fibrous Histiocytoma, Metastatic, Uncertain
Primary Site 1 (2%)
Sarcoma, Metastatic, Tissue NOS 1 (2%)
Schwannoma Malignant, Metastatic, Stomach 1 (2%)
Pharynx (2)
Palate, Squamous Cell Papilloma 1 (50%)
Stomach, Forestomach (46) (50)
Schwannoma Malignant 1 (2%)
Stomach, Glandular (50) (49)
Tongue (1) (1)
Squamous Cell Papilloma 1 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
Page 2
NTP Experiment-Test: 05078-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ETHYL CHLORIDE Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:04:19
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 15000 PP
M
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50)
Fibrous Histiocytoma, Metastatic, Uncertain
Primary Site 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (50) (50)
Adrenal Gland, Cortex (50) (50)
Adenoma 2 (4%) 1 (2%)
Fibrous Histiocytoma, Metastatic, Skeletal
Muscle 1 (2%)
Sarcoma, Metastatic, Bone 1 (2%)
Adrenal Gland, Medulla (35) (40)
Pheochromocytoma Malignant 1 (3%)
Pheochromocytoma Benign 1 (3%) 2 (5%)
Sarcoma, Metastatic, Bone 1 (3%)
Islets, Pancreatic (49) (50)
Carcinoma 1 (2%)
Pituitary Gland (49) (50)
Pars Distalis, Adenoma 26 (53%) 30 (60%)
Pars Distalis, Carcinoma 6 (12%) 3 (6%)
Pars Distalis, Carcinoma, Metastatic,
Zymbal's Gland 1 (2%)
Thyroid Gland (49) (48)
C-Cell, Adenoma 5 (10%) 2 (4%)
C-Cell, Carcinoma 3 (6%) 1 (2%)
Follicular Cell, Adenoma 1 (2%)
Follicular Cell, Carcinoma 2 (4%) 3 (6%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (1)
Sarcoma 1 (100%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (46) (43)
Adenoma 1 (2%) 4 (9%)
Carcinoma 2 (4%) 1 (2%)
Ovary (49) (50)
Granulosa Cell Tumor Malignant 1 (2%)
Uterus (49) (50)
Polyp Stromal 2 (4%) 7 (14%)
Page 3
NTP Experiment-Test: 05078-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ETHYL CHLORIDE Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:04:19
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 15000 PP
M
____________________________________________________________________________________________________________________________________
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50)
Sarcoma, Metastatic, Bone 1 (2%)
Lymph Node (48) (49)
Lymph Node, Bronchial (47) (47)
Fibrous Histiocytoma, Metastatic, Uncertain
Primary Site 1 (2%)
Fibrous Histiocytoma, Metastatic, Skeletal
Muscle 1 (2%)
Sarcoma, Metastatic, Bone 1 (2%)
Mesenteric, Sarcoma, Metastatic, Tissue NOS 1 (2%)
Lymph Node, Mandibular (39) (43)
Spleen (50) (50)
Fibrous Histiocytoma, Metastatic 1 (2%)
Hemangiosarcoma 1 (2%)
Thymus (38) (39)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (48) (50)
Adenocarcinoma 1 (2%)
Adenoma 2 (4%) 1 (2%)
Fibroadenoma 11 (23%) 8 (16%)
Fibroadenoma, Multiple 1 (2%) 1 (2%)
Skin (47) (49)
Basal Cell Carcinoma 1 (2%)
Subcutaneous Tissue, Fibroma 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50)
Fibrous Histiocytoma, Metastatic, Skeletal
Muscle 1 (2%)
Osteosarcoma 1 (2%)
Skeletal Muscle (1)
Fibrous Histiocytoma 1 (100%)
____________________________________________________________________________________________________________________________________
Page 4
NTP Experiment-Test: 05078-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ETHYL CHLORIDE Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:04:19
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 15000 PP
M
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50)
Astrocytoma Malignant 3 (6%)
Carcinoma, Metastatic, Pituitary Gland 5 (10%) 2 (4%)
Meninges, Carcinoma, Metastatic, Zymbal's
Gland 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (50) (49)
Lung (50) (50)
Basal Cell Carcinoma, Metastatic, Skin 1 (2%)
Carcinoma, Metastatic, Thyroid Gland 1 (2%)
Fibrous Histiocytoma, Metastatic, Uncertain
Primary Site 1 (2%)
Fibrous Histiocytoma, Metastatic, Skeletal
Muscle 1 (2%)
Sarcoma, Metastatic, Bone 1 (2%)
Sarcoma, Metastatic, Ear 1 (2%)
Nose (50) (50)
Trachea (50) (49)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Ear (2)
Sarcoma 1 (50%)
Eye (3) (5)
Zymbal's Gland (2)
Adenoma 1 (50%)
Carcinoma 1 (50%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50)
Fibrous Histiocytoma, Metastatic, Uncertain
Primary Site 1 (2%)
Sarcoma, Metastatic, Bone 1 (2%)
Urinary Bladder (49) (49)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50)
Leukemia Lymphocytic 1 (2%)
* Number of animals with any tissue examined microscopically
Page 5
NTP Experiment-Test: 05078-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ETHYL CHLORIDE Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:04:19
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 15000 PP
M
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS - cont
Multiple Organs *(50) *(50)
Leukemia Mononuclear 20 (40%) 25 (50%)
Lymphoma Malignant Undifferentiated Cell 1 (2%)
____________________________________________________________________________________________________________________________________
Page 6
NTP Experiment-Test: 05078-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ETHYL CHLORIDE Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:04:19
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 15000 PP
M
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 45 48
Total Primary Neoplasms 95 105
Total Animals with Benign Neoplasms 37 38
Total Benign Neoplasms 56 60
Total Animals with Malignant Neoplasms 33 35
Total Malignant Neoplasms 39 45
Total Animals with Metastatic Neoplasms 8 8
Total Metastatic Neoplasm 17 20
Total Animals with Malignant Neoplasms 1
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 7
NTP Experiment-Test: 05078-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ETHYL CHLORIDE Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:04:19
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 15000 PP
M
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50
Early Deaths
Moribund Sacrifice 28 33
Natural Death 6 9
Survivors
Terminal Sacrifice 16 8
Animals Examined Microscopically 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (50) (45)
Liver (50) (50)
Hepatocellular Carcinoma 1 (2%)
Neoplastic Nodule, Multiple 1 (2%)
Mesentery (1) (1)
Pancreas (50) (49)
Stomach (50) (50)
Stomach, Forestomach (48) (49)
Squamous Cell Papilloma 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50)
Schwannoma NOS 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (50)
Adenoma 1 (2%)
Adrenal Gland, Medulla (36) (48)
Pheochromocytoma Malignant 1 (2%)
Pheochromocytoma Benign 7 (19%) 2 (4%)
Bilateral, Pheochromocytoma Benign 1 (3%) 7 (15%)
Islets, Pancreatic (48) (48)
Adenoma 6 (13%) 2 (4%)
Adenoma, Multiple 1 (2%)
Parathyroid Gland (31) (41)
Adenoma 1 (3%)
Pituitary Gland (49) (50)
Pars Distalis, Adenoma 31 (63%) 25 (50%)
Pars Distalis, Carcinoma 1 (2%)
Page 8
NTP Experiment-Test: 05078-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ETHYL CHLORIDE Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:04:19
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 15000 PP
M
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont
Pars Intermedia, Adenoma 1 (2%)
Thyroid Gland (49) (47)
C-Cell, Adenoma 6 (12%) 1 (2%)
C-Cell, Adenoma, Multiple 1 (2%)
C-Cell, Carcinoma 2 (4%)
Follicular Cell, Carcinoma 2 (4%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (1) (4)
Chordoma 1 (25%)
Sarcoma 1 (25%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Preputial Gland (47) (45)
Adenoma 1 (2%) 1 (2%)
Carcinoma 1 (2%) 2 (4%)
Prostate (50) (48)
Sarcoma, Metastatic, Uncertain Primary Site 1 (2%)
Seminal Vesicle (7) (6)
Sarcoma, Metastatic, Uncertain Primary Site 1 (17%)
Testes (50) (50)
Bilateral, Interstitial Cell, Adenoma 19 (38%) 8 (16%)
Interstitial Cell, Adenoma 10 (20%) 17 (34%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (48)
Lymph Node (49) (50)
Sarcoma, Metastatic, Uncertain Primary Site 1 (2%)
Lymph Node, Bronchial (42) (48)
Lymph Node, Mandibular (45) (38)
Spleen (50) (50)
Hemangioma 1 (2%)
Thymus (39) (41)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (13) (14)
Fibroadenoma 1 (8%)
Skin (49) (46)
Basal Cell Carcinoma 3 (7%)
Page 9
NTP Experiment-Test: 05078-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ETHYL CHLORIDE Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:04:19
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 15000 PP
M
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont
Keratoacanthoma 4 (8%) 2 (4%)
Squamous Cell Carcinoma 1 (2%)
Trichoepithelioma 1 (2%)
Lip, Squamous Cell Carcinoma 1 (2%)
Sebaceous Gland, Adenoma 1 (2%)
Subcutaneous Tissue, Fibroma 1 (2%) 2 (4%)
Subcutaneous Tissue, Fibrous Histiocytoma 1 (2%)
Subcutaneous Tissue, Lipoma 1 (2%)
Subcutaneous Tissue, Neurofibrosarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50)
Astrocytoma Malignant 1 (2%)
Granular Cell Tumor Malignant 1 (2%)
Oligodendroglioma Benign 1 (2%)
Oligodendroglioma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (49) (44)
Lung (50) (50)
Sarcoma, Metastatic 1 (2%)
Squamous Cell Carcinoma 1 (2%)
Nose (50) (49)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Zymbal's Gland (1)
Carcinoma 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50)
Lipoma, Moderate 1 (2%)
Renal Tubule, Carcinoma 1 (2%)
Urinary Bladder (50) (49)
Page 10
NTP Experiment-Test: 05078-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ETHYL CHLORIDE Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:04:19
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 15000 PP
M
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont
Sarcoma, Metastatic, Uncertain Primary Site 1 (2%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50)
Leukemia Mononuclear 33 (66%) 36 (72%)
Lymphoma Malignant Histiocytic 1 (2%)
Mesothelioma Benign 1 (2%)
Mesothelioma Malignant 2 (4%) 3 (6%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 11
NTP Experiment-Test: 05078-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC ETHYL CHLORIDE Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:04:19
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 15000 PP
M
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 49 48
Total Primary Neoplasms 142 127
Total Animals with Benign Neoplasms 46 44
Total Benign Neoplasms 95 73
Total Animals with Malignant Neoplasms 39 40
Total Malignant Neoplasms 46 54
Total Animals with Metastatic Neoplasms 1 3
Total Metastatic Neoplasm 4 13
Total Animals with Malignant Neoplasms 1
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant 1
Total Uncertain Neoplasms 1
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 12
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