National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/2479

TR 346 Rat Pathology Tables


                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                           ETHYL CHLORIDE


NTP Experiment-Test: 05078-01                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/10/94
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:04:19




       Facility:  Battelle Northwest

       Chemical CAS #:  75-00-3

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05078-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:04:19  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      15000 PP                                                            
                                                                M                                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50                                                               
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                19           24                                                               
    Natural Death                                                   4                                                               
  Survivors                                                                                                                         
    Terminal Sacrifice                                31           22                                                               
  Animals Examined Microscopically                    50           50                                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (50)         (48)                                                             
      Sarcoma, Metastatic, Bone                        1 (2%)                                                                       
   Intestine Large, Colon                             (50)         (49)                                                             
   Intestine Small, Ileum                             (47)         (43)                                                             
      Sarcoma, Metastatic, Tissue NOS                  1 (2%)                                                                       
   Liver                                              (50)         (50)                                                             
      Fibrous Histiocytoma, Metastatic, Uncertain                                                                                   
          Primary Site                                              1 (2%)                                                          
      Fibrous Histiocytoma, Metastatic, Skeletal                                                                                    
          Muscle                                                    1 (2%)                                                          
      Hepatocellular Carcinoma                         1 (2%)                                                                       
      Sarcoma, Metastatic, Bone                        1 (2%)                                                                       
   Mesentery                                          (1)          (2)                                                              
      Schwannoma Malignant, Metastatic, Stomach                     1 (50%)                                                         
   Pancreas                                           (49)         (50)                                                             
      Fibrous Histiocytoma, Metastatic, Uncertain                                                                                   
          Primary Site                                              1 (2%)                                                          
      Sarcoma, Metastatic, Tissue NOS                  1 (2%)                                                                       
      Schwannoma Malignant, Metastatic, Stomach                     1 (2%)                                                          
   Pharynx                                                         (2)                                                              
      Palate, Squamous Cell Papilloma                               1 (50%)                                                         
   Stomach, Forestomach                               (46)         (50)                                                             
      Schwannoma Malignant                                          1 (2%)                                                          
   Stomach, Glandular                                 (50)         (49)                                                             
   Tongue                                             (1)          (1)                                                              
      Squamous Cell Papilloma                          1 (100%)     1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   2                                                               
NTP Experiment-Test: 05078-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:04:19  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      15000 PP                                                            
                                                                M                                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)                                                             
      Fibrous Histiocytoma, Metastatic, Uncertain                                                                                   
          Primary Site                                              1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (50)         (50)                                                             
   Adrenal Gland, Cortex                              (50)         (50)                                                             
      Adenoma                                          2 (4%)       1 (2%)                                                          
      Fibrous Histiocytoma, Metastatic, Skeletal                                                                                    
          Muscle                                                    1 (2%)                                                          
      Sarcoma, Metastatic, Bone                        1 (2%)                                                                       
   Adrenal Gland, Medulla                             (35)         (40)                                                             
      Pheochromocytoma Malignant                                    1 (3%)                                                          
      Pheochromocytoma Benign                          1 (3%)       2 (5%)                                                          
      Sarcoma, Metastatic, Bone                        1 (3%)                                                                       
   Islets, Pancreatic                                 (49)         (50)                                                             
      Carcinoma                                        1 (2%)                                                                       
   Pituitary Gland                                    (49)         (50)                                                             
      Pars Distalis, Adenoma                          26 (53%)     30 (60%)                                                         
      Pars Distalis, Carcinoma                         6 (12%)      3 (6%)                                                          
      Pars Distalis, Carcinoma, Metastatic,                                                                                         
          Zymbal's Gland                                            1 (2%)                                                          
   Thyroid Gland                                      (49)         (48)                                                             
      C-Cell, Adenoma                                  5 (10%)      2 (4%)                                                          
      C-Cell, Carcinoma                                3 (6%)       1 (2%)                                                          
      Follicular Cell, Adenoma                         1 (2%)                                                                       
      Follicular Cell, Carcinoma                       2 (4%)       3 (6%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (1)                                                                           
      Sarcoma                                          1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (46)         (43)                                                             
      Adenoma                                          1 (2%)       4 (9%)                                                          
      Carcinoma                                        2 (4%)       1 (2%)                                                          
   Ovary                                              (49)         (50)                                                             
      Granulosa Cell Tumor Malignant                                1 (2%)                                                          
   Uterus                                             (49)         (50)                                                             
      Polyp Stromal                                    2 (4%)       7 (14%)                                                         
                                                             Page   3                                                               
NTP Experiment-Test: 05078-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:04:19  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      15000 PP                                                            
                                                                M                                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)                                                             
      Sarcoma, Metastatic, Bone                        1 (2%)                                                                       
   Lymph Node                                         (48)         (49)                                                             
   Lymph Node, Bronchial                              (47)         (47)                                                             
      Fibrous Histiocytoma, Metastatic, Uncertain                                                                                   
          Primary Site                                              1 (2%)                                                          
      Fibrous Histiocytoma, Metastatic, Skeletal                                                                                    
          Muscle                                                    1 (2%)                                                          
      Sarcoma, Metastatic, Bone                        1 (2%)                                                                       
      Mesenteric, Sarcoma, Metastatic, Tissue NOS      1 (2%)                                                                       
   Lymph Node, Mandibular                             (39)         (43)                                                             
   Spleen                                             (50)         (50)                                                             
      Fibrous Histiocytoma, Metastatic                              1 (2%)                                                          
      Hemangiosarcoma                                  1 (2%)                                                                       
   Thymus                                             (38)         (39)                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (48)         (50)                                                             
      Adenocarcinoma                                                1 (2%)                                                          
      Adenoma                                          2 (4%)       1 (2%)                                                          
      Fibroadenoma                                    11 (23%)      8 (16%)                                                         
      Fibroadenoma, Multiple                           1 (2%)       1 (2%)                                                          
   Skin                                               (47)         (49)                                                             
      Basal Cell Carcinoma                                          1 (2%)                                                          
      Subcutaneous Tissue, Fibroma                     1 (2%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)                                                             
      Fibrous Histiocytoma, Metastatic, Skeletal                                                                                    
          Muscle                                                    1 (2%)                                                          
      Osteosarcoma                                     1 (2%)                                                                       
   Skeletal Muscle                                                 (1)                                                              
      Fibrous Histiocytoma                                          1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   4                                                               
NTP Experiment-Test: 05078-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:04:19  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      15000 PP                                                            
                                                                M                                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)                                                             
      Astrocytoma Malignant                                         3 (6%)                                                          
      Carcinoma, Metastatic, Pituitary Gland           5 (10%)      2 (4%)                                                          
      Meninges, Carcinoma, Metastatic, Zymbal's                                                                                     
          Gland                                                     1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (50)         (49)                                                             
   Lung                                               (50)         (50)                                                             
      Basal Cell Carcinoma, Metastatic, Skin                        1 (2%)                                                          
      Carcinoma, Metastatic, Thyroid Gland             1 (2%)                                                                       
      Fibrous Histiocytoma, Metastatic, Uncertain                                                                                   
          Primary Site                                              1 (2%)                                                          
      Fibrous Histiocytoma, Metastatic, Skeletal                                                                                    
          Muscle                                                    1 (2%)                                                          
      Sarcoma, Metastatic, Bone                        1 (2%)                                                                       
      Sarcoma, Metastatic, Ear                                      1 (2%)                                                          
   Nose                                               (50)         (50)                                                             
   Trachea                                            (50)         (49)                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                             (2)                                                              
      Sarcoma                                                       1 (50%)                                                         
   Eye                                                (3)          (5)                                                              
   Zymbal's Gland                                                  (2)                                                              
      Adenoma                                                       1 (50%)                                                         
      Carcinoma                                                     1 (50%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)                                                             
      Fibrous Histiocytoma, Metastatic, Uncertain                                                                                   
          Primary Site                                              1 (2%)                                                          
      Sarcoma, Metastatic, Bone                        1 (2%)                                                                       
   Urinary Bladder                                    (49)         (49)                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)                                                             
      Leukemia Lymphocytic                                          1 (2%)                                                          
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   5                                                               
NTP Experiment-Test: 05078-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:04:19  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      15000 PP                                                            
                                                                M                                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SYSTEMIC LESIONS - cont                                                                                                            
   Multiple Organs                                   *(50)        *(50)                                                             
      Leukemia Mononuclear                            20 (40%)     25 (50%)                                                         
      Lymphoma Malignant Undifferentiated Cell         1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                             Page   6                                                               
NTP Experiment-Test: 05078-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:04:19  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      15000 PP                                                            
                                                                M                                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            45          48                                                               
     Total Primary Neoplasms                           95         105                                                               
                                                                                                                                    
   Total Animals with Benign Neoplasms                 37          38                                                               
     Total Benign Neoplasms                            56          60                                                               
                                                                                                                                    
   Total Animals with Malignant Neoplasms              33          35                                                               
     Total Malignant Neoplasms                         39          45                                                               
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              8           8                                                               
     Total Metastatic Neoplasm                         17          20                                                               
                                                                                                                                    
   Total Animals with Malignant Neoplasms                           1                                                               
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   7                                                               
NTP Experiment-Test: 05078-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:04:19  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      15000 PP                                                            
                                                                M                                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50                                                               
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                28           33                                                               
    Natural Death                                      6            9                                                               
  Survivors                                                                                                                         
    Terminal Sacrifice                                16            8                                                               
  Animals Examined Microscopically                    50           50                                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (50)         (45)                                                             
   Liver                                              (50)         (50)                                                             
      Hepatocellular Carcinoma                         1 (2%)                                                                       
      Neoplastic Nodule, Multiple                                   1 (2%)                                                          
   Mesentery                                          (1)          (1)                                                              
   Pancreas                                           (50)         (49)                                                             
   Stomach                                            (50)         (50)                                                             
   Stomach, Forestomach                               (48)         (49)                                                             
      Squamous Cell Papilloma                          1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)                                                             
      Schwannoma NOS                                   1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (50)                                                             
      Adenoma                                          1 (2%)                                                                       
   Adrenal Gland, Medulla                             (36)         (48)                                                             
      Pheochromocytoma Malignant                                    1 (2%)                                                          
      Pheochromocytoma Benign                          7 (19%)      2 (4%)                                                          
      Bilateral, Pheochromocytoma Benign               1 (3%)       7 (15%)                                                         
   Islets, Pancreatic                                 (48)         (48)                                                             
      Adenoma                                          6 (13%)      2 (4%)                                                          
      Adenoma, Multiple                                             1 (2%)                                                          
   Parathyroid Gland                                  (31)         (41)                                                             
      Adenoma                                          1 (3%)                                                                       
   Pituitary Gland                                    (49)         (50)                                                             
      Pars Distalis, Adenoma                          31 (63%)     25 (50%)                                                         
      Pars Distalis, Carcinoma                         1 (2%)                                                                       
                                                             Page   8                                                               
NTP Experiment-Test: 05078-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:04:19  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      15000 PP                                                            
                                                                M                                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
      Pars Intermedia, Adenoma                         1 (2%)                                                                       
   Thyroid Gland                                      (49)         (47)                                                             
      C-Cell, Adenoma                                  6 (12%)      1 (2%)                                                          
      C-Cell, Adenoma, Multiple                        1 (2%)                                                                       
      C-Cell, Carcinoma                                2 (4%)                                                                       
      Follicular Cell, Carcinoma                       2 (4%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (1)          (4)                                                              
      Chordoma                                                      1 (25%)                                                         
      Sarcoma                                                       1 (25%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Preputial Gland                                    (47)         (45)                                                             
      Adenoma                                          1 (2%)       1 (2%)                                                          
      Carcinoma                                        1 (2%)       2 (4%)                                                          
   Prostate                                           (50)         (48)                                                             
      Sarcoma, Metastatic, Uncertain Primary Site                   1 (2%)                                                          
   Seminal Vesicle                                    (7)          (6)                                                              
      Sarcoma, Metastatic, Uncertain Primary Site                   1 (17%)                                                         
   Testes                                             (50)         (50)                                                             
      Bilateral, Interstitial Cell, Adenoma           19 (38%)      8 (16%)                                                         
      Interstitial Cell, Adenoma                      10 (20%)     17 (34%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (48)                                                             
   Lymph Node                                         (49)         (50)                                                             
      Sarcoma, Metastatic, Uncertain Primary Site                   1 (2%)                                                          
   Lymph Node, Bronchial                              (42)         (48)                                                             
   Lymph Node, Mandibular                             (45)         (38)                                                             
   Spleen                                             (50)         (50)                                                             
      Hemangioma                                       1 (2%)                                                                       
   Thymus                                             (39)         (41)                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (13)         (14)                                                             
      Fibroadenoma                                     1 (8%)                                                                       
   Skin                                               (49)         (46)                                                             
      Basal Cell Carcinoma                                          3 (7%)                                                          
                                                             Page   9                                                               
NTP Experiment-Test: 05078-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:04:19  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      15000 PP                                                            
                                                                M                                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - cont                                                                                                         
      Keratoacanthoma                                  4 (8%)       2 (4%)                                                          
      Squamous Cell Carcinoma                                       1 (2%)                                                          
      Trichoepithelioma                                             1 (2%)                                                          
      Lip, Squamous Cell Carcinoma                                  1 (2%)                                                          
      Sebaceous Gland, Adenoma                                      1 (2%)                                                          
      Subcutaneous Tissue, Fibroma                     1 (2%)       2 (4%)                                                          
      Subcutaneous Tissue, Fibrous Histiocytoma                     1 (2%)                                                          
      Subcutaneous Tissue, Lipoma                                   1 (2%)                                                          
      Subcutaneous Tissue, Neurofibrosarcoma                        1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)                                                             
      Astrocytoma Malignant                                         1 (2%)                                                          
      Granular Cell Tumor Malignant                    1 (2%)                                                                       
      Oligodendroglioma Benign                                      1 (2%)                                                          
      Oligodendroglioma Malignant                      1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (49)         (44)                                                             
   Lung                                               (50)         (50)                                                             
      Sarcoma, Metastatic                                           1 (2%)                                                          
      Squamous Cell Carcinoma                                       1 (2%)                                                          
   Nose                                               (50)         (49)                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Zymbal's Gland                                     (1)                                                                           
      Carcinoma                                        1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)                                                             
      Lipoma, Moderate                                 1 (2%)                                                                       
      Renal Tubule, Carcinoma                                       1 (2%)                                                          
   Urinary Bladder                                    (50)         (49)                                                             
                                                             Page  10                                                               
NTP Experiment-Test: 05078-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:04:19  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      15000 PP                                                            
                                                                M                                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - cont                                                                                                               
      Sarcoma, Metastatic, Uncertain Primary Site                   1 (2%)                                                          
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)                                                             
      Leukemia Mononuclear                            33 (66%)     36 (72%)                                                         
      Lymphoma Malignant Histiocytic                   1 (2%)                                                                       
      Mesothelioma Benign                              1 (2%)                                                                       
      Mesothelioma Malignant                           2 (4%)       3 (6%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  11                                                               
NTP Experiment-Test: 05078-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 09/10/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:04:19  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      15000 PP                                                            
                                                                M                                                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            49          48                                                               
     Total Primary Neoplasms                          142         127                                                               
                                                                                                                                    
   Total Animals with Benign Neoplasms                 46          44                                                               
     Total Benign Neoplasms                            95          73                                                               
                                                                                                                                    
   Total Animals with Malignant Neoplasms              39          40                                                               
     Total Malignant Neoplasms                         46          54                                                               
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              1           3                                                               
     Total Metastatic Neoplasm                          4          13                                                               
                                                                                                                                    
   Total Animals with Malignant Neoplasms                           1                                                               
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                  1                                                                           
     Total Uncertain Neoplasms                          1                                                                           
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  12                                                               
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