TR 346 Rat Pathology Tables
NTP Experiment-Test: 05078-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:29:24
Facility: Battelle Northwest
Chemical CAS #: 75-00-3
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05078-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:29:24
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 2| 7| 6| 7| 6| 7| 7| 6| 6| 6| 7| 7|
DAY ON TEST | 2| 1| 6| 2| 2| 2| 2| 2| 1| 2| 2| 2| 6| 5| 2| 5| 2| 5| 2| 2| 5| 3| 5| 2| 2|
| 9| 1| 8| 9| 9| 9| 9| 9| 6| 9| 9| 9| 8| 1| 9| 9| 9| 4| 9| 9| 9| 3| 7| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + M + + + + + + + + + + + + + + M M + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X X X|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + M + + + + + + + I + + +|
Parasite Metazoan | X X X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | I + + + + + + + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Intestine Small, Ileum | + + M + + + + + + + + + + M + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + M + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | 1 1 1 1 1 1 1 2 2 1 1 1 1 1 1|
Degeneration, Fatty | 2 1 3 2 3 2 |
Degeneration | 2 |
Hematopoietic Cell Proliferation | 1 |
Hepatodiaphragmatic Nodule | X X |
Inflammation, Focal, Granulomatous | 1 2 2 1 1 1 1 1 1 |
Leukocytosis | 2 1 |
Necrosis | 1 1 |
Thrombosis | |
Bile Duct, Hyperplasia | 1 1 1 1 |
Hepatocyte, Hyperplasia | 3 |
__________________________________________________________________________|
Mesentery | |
Fat, Inflammation, Chronic | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 2 1 1 2 2 2 |
Cytomegaly | 1|
Inflammation | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Suppurative | 2 |
Duct, Hyperplasia | 1 1 1|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + M + + M + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
Inflammation, Suppurative | |
Ulcer | |
Epithelium, Hyperplasia | 2 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tongue | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05078-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:29:24
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 2| 7| 6| 7| 6| 7| 7| 6| 6| 6| 7| 7|
DAY ON TEST | 2| 1| 6| 2| 2| 2| 2| 2| 1| 2| 2| 2| 6| 5| 2| 5| 2| 5| 2| 2| 5| 3| 5| 2| 2|
| 9| 1| 8| 9| 9| 9| 9| 9| 6| 9| 9| 9| 8| 1| 9| 9| 9| 4| 9| 9| 9| 3| 7| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 1 2 1 2 2 2 2 1 2 1 2 2 1 1 1 2 1 2 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Fatty | 1 2 1 1 2 3 3 |
Focal Cellular Change | 2 |
Hematopoietic Cell Proliferation | |
Hyperplasia | 2 3 2 2 |
Hypertrophy | |
Necrosis | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | M M + + + M + + + + + I + + + + M + + + M + + M M|
Hyperplasia | 3 |
Necrosis | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Parathyroid Gland | M M + + + + + + + I + M M + + + M + M + M + M M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + I + + + + + + + + + + +|
Pars Distalis, Cyst | 2 |
Pars Distalis, Hyperplasia | 1 3 2 2 2 |
Pars Distalis, Metaplasia, Osseous | 3 |
Pars Distalis, Pigmentation, | |
Hemosiderin | |
__________________________________________________________________________|
Thyroid Gland | + M + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 1 3 1 2 2 3 3 1 1 1 1 2 1 2 1 2|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | M + + + + + + + + + + + + M + + + M + + + + M + +|
Cyst | 3 |
Hyperplasia | 2 |
Inflammation, Suppurative | 1 2 1 |
Duct, Hyperplasia | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Cyst | X |
Interstitium, Hyperplasia | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 4 |
Inflammation, Suppurative | |
Endometrium, Hyperplasia, Cystic | 1 |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05078-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:29:24
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 2| 7| 6| 7| 6| 7| 7| 6| 6| 6| 7| 7|
DAY ON TEST | 2| 1| 6| 2| 2| 2| 2| 2| 1| 2| 2| 2| 6| 5| 2| 5| 2| 5| 2| 2| 5| 3| 5| 2| 2|
| 9| 1| 8| 9| 9| 9| 9| 9| 6| 9| 9| 9| 8| 1| 9| 9| 9| 4| 9| 9| 9| 3| 7| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Endometrium, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + M + + +|
Mesenteric, Angiectasis | |
Mesenteric, Inflammation, | |
Granulomatous | |
Renal, Inflammation, Granulomatous | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + M + + M + + +|
Congestion | |
Hyperplasia | 2 |
Inflammation, Granulomatous | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + M + + + + M + + M + + + + + + + + M I M +|
Angiectasis | |
Hyperplasia | 2 2 2|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Hematopoietic Cell Proliferation | |
Inflammation, Focal, Granulomatous | 1 |
__________________________________________________________________________|
Thymus | + M + + + + + M + M + + + + + M + + M + + M + + I|
Epithelial Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + M + + + + + + M + + + +|
Hyperplasia | 2 2 2 2 1 2 2 2 2 2 2 1 2 2 2 2 2 2 2 1|
__________________________________________________________________________|
Skin | + + + + + + M M + + + + + + + + + M + + + + + + +|
Acanthosis | 2 |
Inflammation | 1 |
Subcutaneous Tissue, Inflammation, | |
Chronic | |
Subcutaneous Tissue, Inflammation, | |
Granulomatous | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Focal | |
Necrosis, Focal | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05078-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:29:24
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 2| 7| 6| 7| 6| 7| 7| 6| 6| 6| 7| 7|
DAY ON TEST | 2| 1| 6| 2| 2| 2| 2| 2| 1| 2| 2| 2| 6| 5| 2| 5| 2| 5| 2| 2| 5| 3| 5| 2| 2|
| 9| 1| 8| 9| 9| 9| 9| 9| 6| 9| 9| 9| 8| 1| 9| 9| 9| 4| 9| 9| 9| 3| 7| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 1 1 |
Metaplasia, Squamous | |
Submucosa, Inflammation | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
Foreign Body | 1 |
Infiltration Cellular, Histiocyte | 1 2 2 |
Inflammation, Chronic, Diffuse | |
Inflammation, Chronic, Focal | 1 3 2 |
Inflammation, Granulomatous | 2 |
Alveolar Epithelium, Hyperplasia | 1 |
Mediastinum, Infiltration Cellular, | |
Mononuclear Cell | 2 |
Perivascular, Infiltration Cellular, | |
Mononuclear Cell | 2 2 1 1 1 2 1 1 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 2 2|
Thrombosis | 2 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 1 3 2 1 1 3 |
Respiratory Epithelium, Hyperplasia | 2 2|
Respiratory Epithelium, Metaplasia, | |
Squamous | 3 1|
Submucosa, Inflammation | 2 1 2 1 1 1 1 3 1 2 3|
Vomeronasal Organ, Inflammation, | |
Suppurative | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | +|
Cataract | |
Synechia | |
Bilateral, Cataract | 3|
Retina, Atrophy | 3|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 |
Nephropathy | 2 3 2 2 3 1 2 2 3 2 2 3 2 2 1 2 1 3 1 4 2 3 2|
Renal Tubule, Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05078-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:29:24
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 7| 7| 6| 7| 5| 5| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 5| 7| 7| 7| |
DAY ON TEST | 6| 3| 2| 2| 2| 2| 2| 8| 2| 8| 4| 2| 2| 2| 2| 4| 2| 0| 7| 2| 2| 4| 2| 2| 2| |
| 1| 0| 9| 9| 9| 9| 9| 8| 9| 7| 0| 9| 9| 9| 9| 3| 9| 3| 4| 9| 9| 5| 9| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + M + + + + + + + M +| 45 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X X | 7 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | X X X | 4 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Parasite Metazoan | X X X | 6 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + M + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 3 | 1 3.0|
Basophilic Focus | 1 2 1 2 1 1 1 1 1 1 2 2 1 1 | 29 1.2|
Degeneration, Fatty | 3 2 2 3 | 10 2.3|
Degeneration | 2 | 2 2.0|
Hematopoietic Cell Proliferation | 2 1 | 3 1.3|
Hepatodiaphragmatic Nodule | X | 3 |
Inflammation, Focal, Granulomatous | 2 2 2 1 1 1 1 2 1 1 | 19 1.3|
Leukocytosis | 2 | 3 1.7|
Necrosis | | 2 1.0|
Thrombosis | 3 1 | 2 2.0|
Bile Duct, Hyperplasia | 2 2 1 | 7 1.3|
Hepatocyte, Hyperplasia | 4 | 2 3.5|
__________________________________________________________________________|____________|
Mesentery | + | 1 |
Fat, Inflammation, Chronic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + I + + + +| 49 |
Atrophy | 1 1 2 1 3 1 1 1 | 15 1.5|
Cytomegaly | | 1 1.0|
Inflammation | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + M + + + + + + M + + + + + + + + + + + + +| 48 |
Inflammation, Chronic, Suppurative | | 1 2.0|
Duct, Hyperplasia | 2 | 4 1.3|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + M + + + + + + + + + + + + + M + +| 46 |
Inflammation, Chronic | 2 | 2 2.0|
Inflammation, Suppurative | 3 | 1 3.0|
Ulcer | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 6
NTP Experiment-Test: 05078-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:29:24
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 7| 7| 6| 7| 5| 5| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 5| 7| 7| 7| |
DAY ON TEST | 6| 3| 2| 2| 2| 2| 2| 8| 2| 8| 4| 2| 2| 2| 2| 4| 2| 0| 7| 2| 2| 4| 2| 2| 2| |
| 1| 0| 9| 9| 9| 9| 9| 8| 9| 7| 0| 9| 9| 9| 9| 3| 9| 3| 4| 9| 9| 5| 9| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Epithelium, Hyperplasia | 3 1 3 2 | 6 2.3|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Tongue | + | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 2 1 1 1 2 2 2 2 1 1 2 3 2 1 2 1 2 2 1 2 2 2| 42 1.6|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Fatty | 1 1 1 3 1 2| 13 1.7|
Focal Cellular Change | | 1 2.0|
Hematopoietic Cell Proliferation | 2 2 2 3 1| 5 2.0|
Hyperplasia | 2 2 | 6 2.2|
Hypertrophy | 3 | 1 3.0|
Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + M + M + + + + + + I + + + M + + + I + + M I| 35 |
Hyperplasia | 1 1 3 | 4 2.0|
Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + M + + + +| 49 |
Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + M + + + + + + + M M M + + + + + + + + M + M +| 34 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Pars Distalis, Cyst | X 4 | 3 3.0|
Pars Distalis, Hyperplasia | 2 2 3 1 2 | 10 2.0|
Pars Distalis, Metaplasia, Osseous | | 1 3.0|
Pars Distalis, Pigmentation, | | |
Hemosiderin | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
C-Cell, Hyperplasia | 2 2 1 3 2 1 1 1 2 2 2 2 1 1 1 1| 33 1.6|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
Cyst | 3 | 2 3.0|
Hyperplasia | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 7
NTP Experiment-Test: 05078-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:29:24
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 7| 7| 6| 7| 5| 5| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 5| 7| 7| 7| |
DAY ON TEST | 6| 3| 2| 2| 2| 2| 2| 8| 2| 8| 4| 2| 2| 2| 2| 4| 2| 0| 7| 2| 2| 4| 2| 2| 2| |
| 1| 0| 9| 9| 9| 9| 9| 8| 9| 7| 0| 9| 9| 9| 9| 3| 9| 3| 4| 9| 9| 5| 9| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Inflammation, Suppurative | 2 | 4 1.5|
Duct, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | | 1 2.0|
Cyst | 2 | 2 2.0|
Interstitium, Hyperplasia | 2 1 | 2 1.5|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hemorrhage | | 1 4.0|
Inflammation, Suppurative | 1 | 1 1.0|
Endometrium, Hyperplasia, Cystic | | 1 1.0|
Endometrium, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Myelofibrosis | 2 | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + M + + + +| 48 |
Mesenteric, Angiectasis | 2 | 1 2.0|
Mesenteric, Inflammation, | | |
Granulomatous | 2 | 1 2.0|
Renal, Inflammation, Granulomatous | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + M + + + +| 47 |
Congestion | 4 | 1 4.0|
Hyperplasia | | 1 2.0|
Inflammation, Granulomatous | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + M + + + + + M M + + + + + + + + M M + + +| 39 |
Angiectasis | 2 | 1 2.0|
Hyperplasia | 2 2 2 2 3 2| 9 2.1|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 2 | 1 2.0|
Hematopoietic Cell Proliferation | 2 | 1 2.0|
Inflammation, Focal, Granulomatous | | 1 1.0|
__________________________________________________________________________|____________|
Thymus | + + + + + M M + + + + + + M + + + + + + M + + + M| 38 |
Epithelial Cell, Hyperplasia | | 1 1.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia | 2 1 1 1 2 2 1 2 2 2 1 1 1 2 2 1 2 2 1 2 1 2 2 2 1| 45 1.7|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Acanthosis | 3 | 2 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 05078-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:29:24
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 7| 7| 6| 7| 5| 5| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 5| 7| 7| 7| |
DAY ON TEST | 6| 3| 2| 2| 2| 2| 2| 8| 2| 8| 4| 2| 2| 2| 2| 4| 2| 0| 7| 2| 2| 4| 2| 2| 2| |
| 1| 0| 9| 9| 9| 9| 9| 8| 9| 7| 0| 9| 9| 9| 9| 3| 9| 3| 4| 9| 9| 5| 9| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Inflammation | | 1 1.0|
Subcutaneous Tissue, Inflammation, | | |
Chronic | 2 | 1 2.0|
Subcutaneous Tissue, Inflammation, | | |
Granulomatous | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage, Focal | 2 2 | 2 2.0|
Necrosis, Focal | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 1 1 1 2 1 2 1| 10 1.3|
Metaplasia, Squamous | 1 | 1 1.0|
Submucosa, Inflammation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | | 1 2.0|
Foreign Body | | 1 1.0|
Infiltration Cellular, Histiocyte | 2 1 2 2 1 | 8 1.6|
Inflammation, Chronic, Diffuse | 2 | 1 2.0|
Inflammation, Chronic, Focal | 2 | 4 2.0|
Inflammation, Granulomatous | | 1 2.0|
Alveolar Epithelium, Hyperplasia | 2 1 4 | 4 2.0|
Mediastinum, Infiltration Cellular, | | |
Mononuclear Cell | | 1 2.0|
Perivascular, Infiltration Cellular, | | |
Mononuclear Cell | 1 2 2 1 1 1 2 1 1 1 1 1 | 21 1.3|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 1 1 1 | 6 1.3|
Thrombosis | 3 | 2 2.5|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 1 3 1 1 1 1| 12 1.6|
Respiratory Epithelium, Hyperplasia | 1 1 | 4 1.5|
Respiratory Epithelium, Metaplasia, | | |
Squamous | | 2 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 05078-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:29:24
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 7| 7| 6| 7| 5| 5| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 5| 7| 7| 7| |
DAY ON TEST | 6| 3| 2| 2| 2| 2| 2| 8| 2| 8| 4| 2| 2| 2| 2| 4| 2| 0| 7| 2| 2| 4| 2| 2| 2| |
| 1| 0| 9| 9| 9| 9| 9| 8| 9| 7| 0| 9| 9| 9| 9| 3| 9| 3| 4| 9| 9| 5| 9| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Submucosa, Inflammation | 1 1 2 1 2 3 2 2 2 1 2 1 1 1| 25 1.6|
Vomeronasal Organ, Inflammation, | | |
Suppurative | 1 | 1 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 1 | 2 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + M + | 3 |
Cataract | 2 | 1 2.0|
Synechia | 2 | 1 2.0|
Bilateral, Cataract | | 1 3.0|
Retina, Atrophy | | 1 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 1 | 2 1.5|
Nephropathy | 2 1 2 2 2 1 3 3 3 1 3 3 1 1 3 2 2 1 2 3 3 3 3 2| 47 2.2|
Renal Tubule, Hyperplasia, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 05078-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:29:24
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 5| 7| 6| 5| 5| 7| 7| 7| 6| 6| 5| 5| 7| 6| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 2| 2| 3| 8| 9| 0| 8| 7| 5| 3| 3| 3| 8| 1| 9| 7| 3| 5| 3|
| 0| 0| 0| 0| 0| 0| 0| 3| 0| 8| 4| 7| 9| 4| 9| 0| 0| 0| 8| 2| 9| 3| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
15000 PP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
M | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + A + + + +|
Anus, Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + A + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + A + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + M + + + + + M A M + + +|
Parasite Metazoan | X X X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + M + M + + + + + + + A A + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + A A + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | 1 2 1 1 1 1 1 2 1 2 2|
Congestion | 2 |
Degeneration, Fatty | 2 2 1 2 |
Degeneration | 3 |
Hematopoietic Cell Proliferation | 2 2 1 |
Inflammation, Focal, Granulomatous | 2 1 1 1 2 1 1 1 1 1 1 |
Leukocytosis | 2 |
Necrosis | 1 1 1 1|
Pigmentation | 2 |
Bile Duct, Hyperplasia | 1 1 1 1 2 2 1 1 1 1 |
__________________________________________________________________________|
Mesentery | |
Fat, Inflammation, Chronic | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 1 2 1 1 3 |
Cytomegaly | 1 |
Hyperplasia | |
Artery, Mineralization | 2 |
__________________________________________________________________________|
Pharynx | + |
Palate, Inflammation, Chronic | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
Duct, Hyperplasia | 1 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 3 |
Ulcer | 2 |
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 05078-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:29:24
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 5| 7| 6| 5| 5| 7| 7| 7| 6| 6| 5| 5| 7| 6| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 2| 2| 3| 8| 9| 0| 8| 7| 5| 3| 3| 3| 8| 1| 9| 7| 3| 5| 3|
| 0| 0| 0| 0| 0| 0| 0| 3| 0| 8| 4| 7| 9| 4| 9| 0| 0| 0| 8| 2| 9| 3| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
15000 PP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
M | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Tongue | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
Inflammation | 2 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 2 1 2 2 2 2 1 2 1 3 1 2 2 2 1 2 1 2 2 |
Artery, Mineralization | 3 |
Atrium, Thrombosis | 1 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Fatty | 2 1 2 1 2 3 1 1 2 2 |
Degeneration | 3 |
Hematopoietic Cell Proliferation | 1 1 2 1 1 |
Hemorrhage | 2 |
Hyperplasia | 2 2 1 2|
Hypertrophy | 3 |
__________________________________________________________________________|
Adrenal Gland, Medulla | I M + + + + + + + + M + + + M + I M + M + + + + +|
Hyperplasia | 2 4 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + M + + + + M + M M M + + + + + + + M M M M + +|
Hyperplasia | 4 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | X X |
Pars Distalis, Hemorrhage | 2 |
Pars Distalis, Hyperplasia | 3 4 2 2 2 |
Pars Distalis, Infiltration Cellular,| |
Mixed Cell | 1 |
Pars Distalis, Pigmentation, | |
Hemosiderin | 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + M + + + + + + + + + A + + + +|
Mineralization | 1 |
C-Cell, Hyperplasia | 4 1 1 1 2 2 2 1 1 1 1 2 1 2 2 2|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + I + + M M + + + + + M + + M + +|
Hyperplasia | |
Inflammation, Suppurative | 1 1 |
Duct, Hyperplasia | 4 |
_____________________________________________________________________________________________________________________|
Page 12
NTP Experiment-Test: 05078-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:29:24
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 5| 7| 6| 5| 5| 7| 7| 7| 6| 6| 5| 5| 7| 6| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 2| 2| 3| 8| 9| 0| 8| 7| 5| 3| 3| 3| 8| 1| 9| 7| 3| 5| 3|
| 0| 0| 0| 0| 0| 0| 0| 3| 0| 8| 4| 7| 9| 4| 9| 0| 0| 0| 8| 2| 9| 3| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
15000 PP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
M | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 2 2 3 |
Cyst | 2 1|
Interstitium, Hyperplasia | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Endometrium, Hyperplasia, Cystic | 4 |
Endometrium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + M + + + + + + + + +|
Congestion | 3 |
Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + M + + + + + + + + + + + + + + + + M|
Depletion Cellular | 4 |
Hyperplasia | 2 2 2 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematocyst | 2 |
Hematopoietic Cell Proliferation | 3 2 3 3 |
Inflammation, Focal, Granulomatous | 2 1 |
Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Thymus | M M + + + + + + M + + M + + M + + M + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 1 1 2 1 2 1 2 1 2 2 2 1 1 2 2 1 2 2 1 2 2 2|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + M + +|
Acanthosis | 4 2 |
Inflammation, Suppurative | 2 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 3 |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Gliosis | 2 |
Hemorrhage, Focal | 3 1 |
Inflammation | |
Necrosis, Focal | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 13
NTP Experiment-Test: 05078-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:29:24
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 5| 7| 6| 5| 5| 7| 7| 7| 6| 6| 5| 5| 7| 6| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 2| 2| 3| 8| 9| 0| 8| 7| 5| 3| 3| 3| 8| 1| 9| 7| 3| 5| 3|
| 0| 0| 0| 0| 0| 0| 0| 3| 0| 8| 4| 7| 9| 4| 9| 0| 0| 0| 8| 2| 9| 3| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
15000 PP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
M | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + M + + + + +|
Inflammation, Suppurative | 2 1 1 1 1 |
Epithelium, Hyperplasia | 1 2 |
Submucosa, Inflammation | 2 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Edema | 2 |
Hemorrhage | 2 3 1 |
Infiltration Cellular, Histiocyte | 2 2 3 1 |
Inflammation, Chronic, Diffuse | 2 |
Inflammation, Chronic, Focal | 2 |
Mineralization | 2 |
Necrosis | 1 |
Thrombosis | 1 |
Alveolar Epithelium, Hyperplasia | 1 1 2 1 |
Bronchiole, Epithelium, Hyperplasia | |
Perivascular, Infiltration Cellular, | |
Mononuclear Cell | 1 1 1 2 1 2 1 2 2 2 1 1|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 |
Thrombosis | 1 2 3 3 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 1 1 1 |
Respiratory Epithelium, Hyperplasia | 1 1 1 2 1 |
Respiratory Epithelium, Metaplasia, | |
Squamous | 2 |
Submucosa, Inflammation | 2 1 1 1 1 1 2 2 1 3 2 1 1 1 1 1 1 |
Vomeronasal Organ, Inflammation, | |
Suppurative | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + A + + + + +|
Inflammation, Suppurative | 1 |
Epithelium, Hyperplasia | |
Submucosa, Inflammation | 2 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + + + |
Cataract | 2 |
Hemorrhage | 2 |
Inflammation, Chronic | |
Synechia | 4 |
Bilateral, Cataract | 4 |
Retina, Atrophy | 4 2 |
_____________________________________________________________________________________________________________________|
Page 14
NTP Experiment-Test: 05078-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:29:24
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 5| 7| 6| 5| 5| 7| 7| 7| 6| 6| 5| 5| 7| 6| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 2| 2| 3| 8| 9| 0| 8| 7| 5| 3| 3| 3| 8| 1| 9| 7| 3| 5| 3|
| 0| 0| 0| 0| 0| 0| 0| 3| 0| 8| 4| 7| 9| 4| 9| 0| 0| 0| 8| 2| 9| 3| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
15000 PP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
M | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Harderian Gland | + |
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | |
Mineralization | 2 |
Nephropathy | 3 3 2 3 2 2 1 2 1 1 3 2 4 2 3 2 2 1 2 1 2 1 2|
Renal Tubule, Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + M + + +|
Hemorrhage | 2 |
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05078-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:29:24
__________________________________________________________________________________________________________________________________
| 5| 7| 6| 5| 7| 7| 6| 7| 6| 6| 5| 6| 7| 7| 7| 5| 7| 4| 3| 6| 7| 7| 7| 5| 5| |
DAY ON TEST | 4| 3| 0| 7| 3| 3| 7| 3| 2| 7| 8| 4| 3| 3| 3| 3| 3| 9| 6| 2| 3| 1| 3| 4| 6| |
| 5| 0| 8| 3| 0| 0| 9| 0| 2| 2| 8| 3| 0| 0| 0| 5| 0| 0| 4| 9| 0| 4| 0| 6| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
15000 PP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
M | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Anus, Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + A + + +| 48 |
Parasite Metazoan | X X X X X| 6 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Parasite Metazoan | X X X X X | 7 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + M + + + + + + + + + + + + + + A + + + + + +| 44 |
Parasite Metazoan | | 3 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + A + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + A + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + M + + M + + + + + + + + A + + + + + +| 43 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + A + + + + + +| 47 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 1 | 1 1.0|
Basophilic Focus | 1 1 1 1 1 1 1 1 1 2 1 | 22 1.2|
Congestion | | 1 2.0|
Degeneration, Fatty | 3 2 | 6 2.0|
Degeneration | 2 | 2 2.5|
Hematopoietic Cell Proliferation | 2 2 | 5 1.8|
Inflammation, Focal, Granulomatous | 2 1 1 1 1 1 2 1 2 1 | 21 1.2|
Leukocytosis | | 1 2.0|
Necrosis | 1 1 1 2| 8 1.1|
Pigmentation | | 1 2.0|
Bile Duct, Hyperplasia | 1 2 | 12 1.3|
__________________________________________________________________________|____________|
Mesentery | + + | 2 |
Fat, Inflammation, Chronic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 1 3 1 | 9 1.7|
Cytomegaly | 1 | 2 1.0|
Hyperplasia | 3 | 1 3.0|
Artery, Mineralization | | 1 2.0|
__________________________________________________________________________|____________|
Pharynx | + | 2 |
Palate, Inflammation, Chronic | 3 | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | | 1 2.0|
Duct, Hyperplasia | 1 2 2 1 | 6 1.3|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 16
NTP Experiment-Test: 05078-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:29:24
__________________________________________________________________________________________________________________________________
| 5| 7| 6| 5| 7| 7| 6| 7| 6| 6| 5| 6| 7| 7| 7| 5| 7| 4| 3| 6| 7| 7| 7| 5| 5| |
DAY ON TEST | 4| 3| 0| 7| 3| 3| 7| 3| 2| 7| 8| 4| 3| 3| 3| 3| 3| 9| 6| 2| 3| 1| 3| 4| 6| |
| 5| 0| 8| 3| 0| 0| 9| 0| 2| 2| 8| 3| 0| 0| 0| 5| 0| 0| 4| 9| 0| 4| 0| 6| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
15000 PP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
M | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Ulcer | 4 | 1 4.0|
Epithelium, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + M + + + + + + + +| 49 |
Mineralization | | 1 3.0|
Ulcer | | 1 2.0|
__________________________________________________________________________|____________|
Tongue | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
Inflammation | | 1 2.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 2 1 1 2 2 2 2 3 1 1 1 2 1 2 2 2 1 2 2 2 1 | 41 1.7|
Artery, Mineralization | | 1 3.0|
Atrium, Thrombosis | | 2 1.5|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Fatty | 2 3 3 1 2 2 3 1 | 18 1.9|
Degeneration | | 1 3.0|
Hematopoietic Cell Proliferation | 2| 6 1.3|
Hemorrhage | | 1 2.0|
Hyperplasia | 1 2 2 2 2 | 9 1.8|
Hypertrophy | | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + M + I + + + + + + M +| 40 |
Hyperplasia | 2 | 3 2.7|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + M + + + + + M M M + + + I M + M + + M M + + +| 31 |
Hyperplasia | | 1 4.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Cyst | 2 2 | 4 2.0|
Pars Distalis, Hemorrhage | | 1 2.0|
Pars Distalis, Hyperplasia | 2 3 3 2 3 1 | 11 2.5|
Pars Distalis, Infiltration Cellular,| | |
Mixed Cell | | 1 1.0|
Pars Distalis, Pigmentation, | | |
Hemosiderin | | 2 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Mineralization | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 17
NTP Experiment-Test: 05078-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:29:24
__________________________________________________________________________________________________________________________________
| 5| 7| 6| 5| 7| 7| 6| 7| 6| 6| 5| 6| 7| 7| 7| 5| 7| 4| 3| 6| 7| 7| 7| 5| 5| |
DAY ON TEST | 4| 3| 0| 7| 3| 3| 7| 3| 2| 7| 8| 4| 3| 3| 3| 3| 3| 9| 6| 2| 3| 1| 3| 4| 6| |
| 5| 0| 8| 3| 0| 0| 9| 0| 2| 2| 8| 3| 0| 0| 0| 5| 0| 0| 4| 9| 0| 4| 0| 6| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
15000 PP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
M | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
C-Cell, Hyperplasia | 2 1 3 1 1 2 2 2 1 1 1 1 1 1 1 | 31 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + M + M + + + + + + + + + + + + + + + +| 43 |
Hyperplasia | 4 | 1 4.0|
Inflammation, Suppurative | 3 | 3 1.7|
Duct, Hyperplasia | | 1 4.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 4 2.5|
Cyst | 1 2 1 | 5 1.4|
Interstitium, Hyperplasia | 4 | 1 4.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Endometrium, Hyperplasia, Cystic | | 1 4.0|
Endometrium, Hyperplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Histiocyte | 4 | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + M + + + +| 49 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | I + + + + + + + + + + + + + + + + + + + M + + + +| 47 |
Congestion | | 1 3.0|
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + M + + + + + + + M M + + + + + + + + M + + + M| 43 |
Depletion Cellular | | 1 4.0|
Hyperplasia | 2 2 3 2 | 8 2.1|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematocyst | | 1 2.0|
Hematopoietic Cell Proliferation | 2 2 2 | 7 2.4|
Inflammation, Focal, Granulomatous | | 2 1.5|
Pigmentation, Hemosiderin | 1 2 | 2 1.5|
__________________________________________________________________________|____________|
Thymus | + + + + + + M M M M + + + M + + + + + + + + + + +| 39 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 1 1 1 2 1 2 1 2 2 2 2 2 2 2 1 2 2 4 2 2 2 2| 47 1.7|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 18
NTP Experiment-Test: 05078-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:29:24
__________________________________________________________________________________________________________________________________
| 5| 7| 6| 5| 7| 7| 6| 7| 6| 6| 5| 6| 7| 7| 7| 5| 7| 4| 3| 6| 7| 7| 7| 5| 5| |
DAY ON TEST | 4| 3| 0| 7| 3| 3| 7| 3| 2| 7| 8| 4| 3| 3| 3| 3| 3| 9| 6| 2| 3| 1| 3| 4| 6| |
| 5| 0| 8| 3| 0| 0| 9| 0| 2| 2| 8| 3| 0| 0| 0| 5| 0| 0| 4| 9| 0| 4| 0| 6| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
15000 PP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
M | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Acanthosis | | 2 3.0|
Inflammation, Suppurative | 2 | 3 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | | 1 3.0|
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Gliosis | | 1 2.0|
Hemorrhage, Focal | | 2 2.0|
Inflammation | 1 | 1 1.0|
Necrosis, Focal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Suppurative | 1 1 | 7 1.1|
Epithelium, Hyperplasia | | 2 1.5|
Submucosa, Inflammation | | 1 2.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 4 3 | 2 3.5|
Edema | 2 | 2 2.0|
Hemorrhage | 1 | 4 1.8|
Infiltration Cellular, Histiocyte | 1 1 2 1 2 1 1 1 1| 13 1.5|
Inflammation, Chronic, Diffuse | | 1 2.0|
Inflammation, Chronic, Focal | 2 1 2| 4 1.8|
Mineralization | | 1 2.0|
Necrosis | | 1 1.0|
Thrombosis | | 1 1.0|
Alveolar Epithelium, Hyperplasia | 4 2 1 2 | 8 1.8|
Bronchiole, Epithelium, Hyperplasia | 2 | 1 2.0|
Perivascular, Infiltration Cellular, | | |
Mononuclear Cell | 1 2 1 1 1 2 1 | 19 1.4|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 2 1 2 1 1 | 6 1.3|
Thrombosis | 1 | 5 2.0|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 3 3 1 2 2 2 | 10 1.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 19
NTP Experiment-Test: 05078-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:29:24
__________________________________________________________________________________________________________________________________
| 5| 7| 6| 5| 7| 7| 6| 7| 6| 6| 5| 6| 7| 7| 7| 5| 7| 4| 3| 6| 7| 7| 7| 5| 5| |
DAY ON TEST | 4| 3| 0| 7| 3| 3| 7| 3| 2| 7| 8| 4| 3| 3| 3| 3| 3| 9| 6| 2| 3| 1| 3| 4| 6| |
| 5| 0| 8| 3| 0| 0| 9| 0| 2| 2| 8| 3| 0| 0| 0| 5| 0| 0| 4| 9| 0| 4| 0| 6| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
15000 PP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
M | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Respiratory Epithelium, Hyperplasia | 2 1 1 2 1 | 10 1.3|
Respiratory Epithelium, Metaplasia, | | |
Squamous | | 1 2.0|
Submucosa, Inflammation | 1 2 1 1 1 1 2 1 2 2 2 1 2 2 1 1 1| 34 1.4|
Vomeronasal Organ, Inflammation, | | |
Suppurative | | 1 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Suppurative | | 1 1.0|
Epithelium, Hyperplasia | 2 | 1 2.0|
Submucosa, Inflammation | 1 | 2 1.5|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + + | 2 |
__________________________________________________________________________|____________|
Eye | + + | 5 |
Cataract | 4 | 2 3.0|
Hemorrhage | | 1 2.0|
Inflammation, Chronic | 4 | 1 4.0|
Synechia | | 1 4.0|
Bilateral, Cataract | | 1 4.0|
Retina, Atrophy | | 2 3.0|
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
Inflammation, Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Zymbal's Gland | + | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hydronephrosis | 1 | 1 1.0|
Mineralization | | 1 2.0|
Nephropathy | 2 3 2 2 1 2 1 1 2 2 2 1 2 1 3 2 2 2 1| 42 1.9|
Renal Tubule, Hyperplasia, Focal | 3 | 2 2.5|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hemorrhage | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 20
NTP Experiment-Test: 05078-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:29:24
_____________________________________________________________________________________________________________________
| 6| 6| 7| 6| 6| 6| 7| 6| 5| 6| 4| 6| 7| 6| 6| 6| 5| 7| 6| 7| 7| 7| 6| 5| 7|
DAY ON TEST | 8| 9| 3| 9| 8| 6| 3| 9| 7| 7| 8| 5| 3| 4| 7| 5| 7| 3| 9| 3| 3| 3| 6| 2| 2|
| 2| 6| 0| 6| 2| 8| 0| 8| 0| 1| 5| 8| 0| 5| 5| 4| 0| 0| 9| 0| 0| 0| 5| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + M + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X X|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + M + + + + + + + + + + + + + + + + + + + M + +|
Parasite Metazoan | X X X |
Serosa, Inflammation, Chronic | 4 |
Serosa, Thrombosis | 4 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + M + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + M + + + + + M + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + A + + + + M + + + A + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 1 1 1 1 1 1 |
Clear Cell Focus | 2 |
Degeneration, Cystic | 1|
Degeneration, Fatty | 1 2 3 2 |
Degeneration | 4 1 |
Fibrosis | 2 |
Hemorrhage | |
Hepatodiaphragmatic Nodule | X X |
Inflammation, Focal, Granulomatous | 1 |
Necrosis | 2 2 1 1 1 1 2 |
Bile Duct, Hyperplasia | 2 3 2 2 3 2 2 2 2 2 3 2 1 2 2 2 1 2 2 1 1 2|
Hepatocyte, Hyperplasia | 3 3 |
__________________________________________________________________________|
Mesentery | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 1 3 1 1 1 1 1 2 2 2 1 4 |
Cytomegaly | 1 1 |
Pigmentation, Hemosiderin | 3 |
Artery, Intima, Hyperplasia | |
__________________________________________________________________________|
Pharynx | |
Palate, Inflammation, Chronic | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Hyperplasia | 1 1 1 |
Duct, Inflammation, Suppurative | 1 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + M + + + + + I + + + +|
Inflammation, Chronic | 4 |
Inflammation, Suppurative | 3 1 2 |
Ulcer | 3 1 3 |
Epithelium, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05078-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:29:24
_____________________________________________________________________________________________________________________
| 6| 6| 7| 6| 6| 6| 7| 6| 5| 6| 4| 6| 7| 6| 6| 6| 5| 7| 6| 7| 7| 7| 6| 5| 7|
DAY ON TEST | 8| 9| 3| 9| 8| 6| 3| 9| 7| 7| 8| 5| 3| 4| 7| 5| 7| 3| 9| 3| 3| 3| 6| 2| 2|
| 2| 6| 0| 6| 2| 8| 0| 8| 0| 1| 5| 8| 0| 5| 5| 4| 0| 0| 9| 0| 0| 0| 5| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | +|
Gingiva, Hyperplasia, | |
Pseudoepitheliomatous | 4|
Peridontal Tissue, Inflammation, | |
Chronic, Suppurative | 3|
Pulp, Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 3 2 2 2 2 2 2 1 3 2 2 2 1 2 2 2 2 2 2 2|
Atrium, Thrombosis | 2 3 |
Perivascular, Inflammation | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Fatty | 2 1 1 2 1 1 1 2 1 2 2 1 2 |
Hematopoietic Cell Proliferation | 2 |
Hyperplasia | 2 1 3 2 1 2 |
Hypertrophy | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + M + + + M + + M + + M M M + + + + + + + M +|
Hyperplasia | 4 3 2 1 4 4 1 3 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + M + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Parathyroid Gland | M M M M + + M M + + M M M M + + + + + + M + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + M + + + + +|
Pars Distalis, Cyst | |
Pars Distalis, Hemorrhage | 4 |
Pars Distalis, Hyperplasia | 4 1 3 1 |
Pars Distalis, Necrosis | 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + M + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 1 2 4 2 3 4|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
Inflammation, Chronic | 2 |
Necrosis | 3 |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + M + M M + + M + + + + M + + + + + + +|
Inflammation, Chronic | |
Mineralization | 3 |
Vacuolization Cytoplasmic | 2 3 2 1 2 3 3 4|
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05078-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:29:24
_____________________________________________________________________________________________________________________
| 6| 6| 7| 6| 6| 6| 7| 6| 5| 6| 4| 6| 7| 6| 6| 6| 5| 7| 6| 7| 7| 7| 6| 5| 7|
DAY ON TEST | 8| 9| 3| 9| 8| 6| 3| 9| 7| 7| 8| 5| 3| 4| 7| 5| 7| 3| 9| 3| 3| 3| 6| 2| 2|
| 2| 6| 0| 6| 2| 8| 0| 8| 0| 1| 5| 8| 0| 5| 5| 4| 0| 0| 9| 0| 0| 0| 5| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + I + M + + + + + + + + + + +|
Cyst | X |
Inflammation, Suppurative | 2 1 1 2 2 1 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 4 |
Inflammation, Chronic | 3 |
Inflammation, Suppurative | 3 2 1 1 1 4 2 2 2 1 |
__________________________________________________________________________|
Seminal Vesicle | + + + |
Inflammation, Suppurative | 2 2 1 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 3 4 4 4 3 4 3 3 4 1 3 4 3|
Interstitial Cell, Hyperplasia | 1 2 1 1 1 |
Perivascular, Inflammation | 2 1 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | 1 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mesenteric, Hematopoietic Cell | |
Proliferation | 2 |
Pancreatic, Hyperplasia | 2 |
Renal, Hematopoietic Cell | |
Proliferation | 2 |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + M M + + + + + + + M + + + + + + + + +|
Hyperplasia | 2 |
Pigmentation, Hemosiderin | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + I + M + + + + + M + + + + + + + +|
Angiectasis | 2 |
Hyperplasia | 2 2 2 2 2 2 3 3 2 2|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 4 2 |
Hematopoietic Cell Proliferation | 2 3 |
__________________________________________________________________________|
Thymus | M + + M + + + + + + + + M M + + + + + M + + + + +|
Epithelial Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M + M M M + M M M + + M M M M M M M M M M M M +|
Hyperplasia | 1 2 2|
__________________________________________________________________________|
Skin | + + + M + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
Inflammation, Chronic | |
Pigmentation, Hemosiderin | |
Prepuce, Abscess | |
Prepuce, Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 23
NTP Experiment-Test: 05078-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:29:24
_____________________________________________________________________________________________________________________
| 6| 6| 7| 6| 6| 6| 7| 6| 5| 6| 4| 6| 7| 6| 6| 6| 5| 7| 6| 7| 7| 7| 6| 5| 7|
DAY ON TEST | 8| 9| 3| 9| 8| 6| 3| 9| 7| 7| 8| 5| 3| 4| 7| 5| 7| 3| 9| 3| 3| 3| 6| 2| 2|
| 2| 6| 0| 6| 2| 8| 0| 8| 0| 1| 5| 8| 0| 5| 5| 4| 0| 0| 9| 0| 0| 0| 5| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Focal | 2 2 3 |
Hydrocephalus | |
Necrosis, Focal | 2 2 |
Meninges, Hemorrhage | 2 |
Meninges, Inflammation, Suppurative | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + I + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 1 1 1 1 2 1 1|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Edema | 3 |
Hemorrhage | 3 1 1 |
Infiltration Cellular, Histiocyte | 2 1 1 |
Infiltration Cellular, Mixed Cell | 3 |
Inflammation, Chronic, Focal | 2 1 1 |
Metaplasia, Osseous | |
Alveolar Epithelium, Hyperplasia | 3 2 1 4 |
Perivascular, Infiltration Cellular, | |
Mononuclear Cell | 1 1 1 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 1 |
Inflammation, Suppurative | 1 2 1 2 1 1 2 2 1|
Thrombosis | 1 2 2 3 2 4 1|
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 2 2 2 1 2 2 2 2 |
Respiratory Epithelium, Hyperplasia | 2 2 1 3 3 2 3 |
Respiratory Epithelium, Metaplasia, | |
Squamous | 1 |
Submucosa, Inflammation | 1 1 2 1 2 2 3 2 2 2 3 2 3 |
Vomeronasal Organ, Inflammation, | |
Suppurative | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | M + |
__________________________________________________________________________|
Eye | +|
_____________________________________________________________________________________________________________________|
Page 24
NTP Experiment-Test: 05078-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:29:24
_____________________________________________________________________________________________________________________
| 6| 6| 7| 6| 6| 6| 7| 6| 5| 6| 4| 6| 7| 6| 6| 6| 5| 7| 6| 7| 7| 7| 6| 5| 7|
DAY ON TEST | 8| 9| 3| 9| 8| 6| 3| 9| 7| 7| 8| 5| 3| 4| 7| 5| 7| 3| 9| 3| 3| 3| 6| 2| 2|
| 2| 6| 0| 6| 2| 8| 0| 8| 0| 1| 5| 8| 0| 5| 5| 4| 0| 0| 9| 0| 0| 0| 5| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
Degeneration | 4|
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fatty Change | |
Hematopoietic Cell Proliferation | 1 2 |
Inflammation, Suppurative | 1 1 1 |
Nephropathy | 3 3 3 3 3 2 2 4 1 4 2 1 3 2 4 3 1 3 2 2 3 4 1 2 2|
Pelvis, Inflammation, Suppurative | 2 |
Pelvis, Necrosis | 2 |
Pelvis, Epithelium, Hyperplasia | |
__________________________________________________________________________|
Urethra | + |
Inflammation, Suppurative | 2 |
Epithelium, Hyperplasia | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 4 |
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 25
NTP Experiment-Test: 05078-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:29:24
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 6| 7| 6| 7| 7| 6| 5| 7| 6| 7| 5| 6| 7| 5| 6| 5| 5| 5| 7| 5| 6| |
DAY ON TEST | 3| 2| 3| 1| 7| 3| 1| 3| 3| 8| 0| 3| 4| 3| 1| 5| 3| 4| 9| 6| 4| 8| 3| 1| 4| |
| 0| 6| 0| 7| 2| 0| 1| 0| 0| 9| 0| 0| 6| 0| 2| 4| 0| 2| 2| 7| 5| 7| 0| 7| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + M + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 |
Parasite Metazoan | X X X X | 8 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | | 5 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + M + + + + + + + + + + + + + + + +| 47 |
Parasite Metazoan | X | 4 |
Serosa, Inflammation, Chronic | | 1 4.0|
Serosa, Thrombosis | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + M + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + A + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | 2 3 1 2 1 1 1 1 1 1 1 1| 18 1.2|
Clear Cell Focus | 1 2 | 3 1.7|
Degeneration, Cystic | 1 1 | 3 1.0|
Degeneration, Fatty | 1 1 2 1 2 | 9 1.7|
Degeneration | | 2 2.5|
Fibrosis | | 1 2.0|
Hemorrhage | 2 | 1 2.0|
Hepatodiaphragmatic Nodule | | 2 |
Inflammation, Focal, Granulomatous | 1 1 2 2 1 | 6 1.3|
Necrosis | | 7 1.4|
Bile Duct, Hyperplasia | 1 2 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 44 1.5|
Hepatocyte, Hyperplasia | 1 | 3 2.3|
__________________________________________________________________________|____________|
Mesentery | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 1 1 2 2 2 1 2 1 2 1 1 | 24 1.5|
Cytomegaly | | 2 1.0|
Pigmentation, Hemosiderin | | 1 3.0|
Artery, Intima, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pharynx | + + | 2 |
Palate, Inflammation, Chronic | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Duct, Hyperplasia | 1 1 1 1 1 1 2 | 10 1.1|
Duct, Inflammation, Suppurative | | 2 1.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 26
NTP Experiment-Test: 05078-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:29:24
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 6| 7| 6| 7| 7| 6| 5| 7| 6| 7| 5| 6| 7| 5| 6| 5| 5| 5| 7| 5| 6| |
DAY ON TEST | 3| 2| 3| 1| 7| 3| 1| 3| 3| 8| 0| 3| 4| 3| 1| 5| 3| 4| 9| 6| 4| 8| 3| 1| 4| |
| 0| 6| 0| 7| 2| 0| 1| 0| 0| 9| 0| 0| 6| 0| 2| 4| 0| 2| 2| 7| 5| 7| 0| 7| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Inflammation, Chronic | 3 | 2 3.5|
Inflammation, Suppurative | | 3 2.0|
Ulcer | 3 | 4 2.5|
Epithelium, Hyperplasia | 2 | 2 2.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Tooth | + +| 3 |
Gingiva, Hyperplasia, | | |
Pseudoepitheliomatous | | 1 4.0|
Peridontal Tissue, Inflammation, | | |
Chronic, Suppurative | 2 | 2 2.5|
Pulp, Inflammation, Suppurative | 2| 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 2 2 1 2 2 2 2 2 3 1 1 1 2 2 2 1 1 3 1 2 4 2 2| 43 1.9|
Atrium, Thrombosis | | 2 2.5|
Perivascular, Inflammation | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Fatty | 1 2 1 1 2 2 1 2 2 2 | 23 1.5|
Hematopoietic Cell Proliferation | 1 | 2 1.5|
Hyperplasia | 3 4 2 3 1 3 3 | 13 2.3|
Hypertrophy | 3 | 2 2.5|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + I + + + M I + + M + M + M M + + + + + + + + + +| 36 |
Hyperplasia | 3 1 | 11 2.5|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + M| 48 |
Hyperplasia | 1 1 | 3 1.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + M M M + + M + + + M + + + + + M + + + M M + + +| 31 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Pars Distalis, Cyst | X | 1 |
Pars Distalis, Hemorrhage | | 1 4.0|
Pars Distalis, Hyperplasia | 1 1 2 3 2 2 | 10 2.0|
Pars Distalis, Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
C-Cell, Hyperplasia | 3 3 2 1 1 1 1 1 1 2 1 1 | 19 1.9|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 27
NTP Experiment-Test: 05078-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:29:24
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 6| 7| 6| 7| 7| 6| 5| 7| 6| 7| 5| 6| 7| 5| 6| 5| 5| 5| 7| 5| 6| |
DAY ON TEST | 3| 2| 3| 1| 7| 3| 1| 3| 3| 8| 0| 3| 4| 3| 1| 5| 3| 4| 9| 6| 4| 8| 3| 1| 4| |
| 0| 6| 0| 7| 2| 0| 1| 0| 0| 9| 0| 0| 6| 0| 2| 4| 0| 2| 2| 7| 5| 7| 0| 7| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
Inflammation, Chronic | | 1 2.0|
Necrosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + I + + M + + M + M M + + + + M + M + M + + + +| 37 |
Inflammation, Chronic | 2 | 1 2.0|
Mineralization | | 1 3.0|
Vacuolization Cytoplasmic | 1 2 3 3 2 3| 14 2.4|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + M + + + + + + + + +| 47 |
Cyst | | 1 |
Inflammation, Suppurative | 1 1 4 2| 10 1.7|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 | 4 2.3|
Inflammation, Chronic | | 1 3.0|
Inflammation, Suppurative | 4 2 1 2 2 2| 16 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + | 7 |
Inflammation, Suppurative | 2 2 2 2 | 7 1.9|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 4 3 2 4 3 2 3 2 3 2 2 3 2| 27 3.0|
Interstitial Cell, Hyperplasia | 1 1 4 1 1 1 1 | 12 1.3|
Perivascular, Inflammation | | 3 1.7|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Myelofibrosis | | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + M + + + + + + + + + + + + + +| 49 |
Mesenteric, Hematopoietic Cell | | |
Proliferation | | 1 2.0|
Pancreatic, Hyperplasia | | 1 2.0|
Renal, Hematopoietic Cell | | |
Proliferation | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + M + + + + M + + M + M + + + + M + + + +| 42 |
Hyperplasia | 1 | 2 1.5|
Pigmentation, Hemosiderin | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + M + + + + + + + + + + + + + M| 45 |
Angiectasis | | 1 2.0|
Hyperplasia | 2 2 2 2 2 2 2 2 1 | 19 2.1|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 28
NTP Experiment-Test: 05078-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:29:24
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 6| 7| 6| 7| 7| 6| 5| 7| 6| 7| 5| 6| 7| 5| 6| 5| 5| 5| 7| 5| 6| |
DAY ON TEST | 3| 2| 3| 1| 7| 3| 1| 3| 3| 8| 0| 3| 4| 3| 1| 5| 3| 4| 9| 6| 4| 8| 3| 1| 4| |
| 0| 6| 0| 7| 2| 0| 1| 0| 0| 9| 0| 0| 6| 0| 2| 4| 0| 2| 2| 7| 5| 7| 0| 7| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 2 | 3 2.7|
Hematopoietic Cell Proliferation | | 2 2.5|
__________________________________________________________________________|____________|
Thymus | + + M + + + M + + + + + M + + M M + + + + + M + +| 39 |
Epithelial Cell, Hyperplasia | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M + M M M M M M M M M + M M M + + M M M M + + + +| 13 |
Hyperplasia | 1 2 1 1 2| 8 1.5|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Acanthosis | 2 | 1 2.0|
Inflammation, Chronic | 3 | 1 3.0|
Pigmentation, Hemosiderin | 1 | 1 1.0|
Prepuce, Abscess | 3 | 1 3.0|
Prepuce, Epithelium, Hyperplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage, Focal | | 3 2.3|
Hydrocephalus | 3 | 1 3.0|
Necrosis, Focal | | 2 2.0|
Meninges, Hemorrhage | | 1 2.0|
Meninges, Inflammation, Suppurative | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Suppurative | 1 1 1 1 1 1| 14 1.1|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | | 1 3.0|
Edema | | 1 3.0|
Hemorrhage | 1 | 4 1.5|
Infiltration Cellular, Histiocyte | 1 2 | 5 1.4|
Infiltration Cellular, Mixed Cell | | 1 3.0|
Inflammation, Chronic, Focal | 3 | 4 1.8|
Metaplasia, Osseous | 1 | 1 1.0|
Alveolar Epithelium, Hyperplasia | 1 2 | 6 2.2|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 29
NTP Experiment-Test: 05078-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:29:24
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 6| 7| 6| 7| 7| 6| 5| 7| 6| 7| 5| 6| 7| 5| 6| 5| 5| 5| 7| 5| 6| |
DAY ON TEST | 3| 2| 3| 1| 7| 3| 1| 3| 3| 8| 0| 3| 4| 3| 1| 5| 3| 4| 9| 6| 4| 8| 3| 1| 4| |
| 0| 6| 0| 7| 2| 0| 1| 0| 0| 9| 0| 0| 6| 0| 2| 4| 0| 2| 2| 7| 5| 7| 0| 7| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Perivascular, Infiltration Cellular, | | |
Mononuclear Cell | 2 1 1 1 1 | 9 1.2|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | | 1 1.0|
Inflammation, Suppurative | 1 2 4 | 12 1.7|
Thrombosis | 2 | 8 2.1|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 1 3 3 | 12 2.0|
Respiratory Epithelium, Hyperplasia | 1 2 | 9 2.1|
Respiratory Epithelium, Metaplasia, | | |
Squamous | | 1 1.0|
Submucosa, Inflammation | 1 1 2 1 1 2 1 2 1 | 22 1.7|
Vomeronasal Organ, Inflammation, | | |
Suppurative | 2| 2 1.5|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 1 | 2 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Eye | | 1 |
Degeneration | | 1 4.0|
__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fatty Change | 4 | 1 4.0|
Hematopoietic Cell Proliferation | | 2 1.5|
Inflammation, Suppurative | 1 | 4 1.0|
Nephropathy | 3 1 3 3 3 2 2 3 3 4 2 4 3 3 1 3 3 2 1 2 3 4 3 3| 49 2.6|
Pelvis, Inflammation, Suppurative | 2 | 2 2.0|
Pelvis, Necrosis | | 1 2.0|
Pelvis, Epithelium, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Urethra | | 1 |
Inflammation, Suppurative | | 1 2.0|
Epithelium, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 2 | 2 3.0|
Transitional Epithelium, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 30
NTP Experiment-Test: 05078-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:29:24
_____________________________________________________________________________________________________________________
| 7| 4| 6| 5| 7| 7| 7| 7| 6| 6| 7| 7| 6| 5| 7| 6| 5| 6| 6| 5| 7| 6| 7| 5| 7|
DAY ON TEST | 2| 7| 7| 5| 2| 1| 2| 0| 2| 6| 2| 2| 8| 8| 0| 4| 8| 2| 1| 4| 2| 3| 1| 1| 0|
| 9| 9| 1| 2| 9| 6| 9| 9| 6| 4| 9| 9| 9| 1| 1| 6| 7| 1| 1| 9| 7| 3| 3| 9| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
15000 PP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
M | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | M M + + + + + + + + + + + + + + M + M + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + A + + A|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + A + + A|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + M A A + + +|
Parasite Metazoan | X X |
Serosa, Inflammation, Chronic | 1 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + A + + + M + + + + + + + + + + + + + A A + M A +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + M + + + + + + + + + + + A A + + + A|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Basophilic Focus | 1 1 1 1 |
Clear Cell Focus | 1 |
Congestion | 3 3 |
Degeneration, Cystic | 1 1 3 2 2 |
Degeneration, Fatty | 1 1 3 |
Degeneration | 2 |
Hematopoietic Cell Proliferation | 2 1 |
Hepatodiaphragmatic Nodule | X |
Inflammation, Focal, Granulomatous | 2 |
Necrosis | 2 |
Pigmentation | |
Bile Duct, Hyperplasia | 2 2 1 1 3 1 2 1 2 2 2 2 2 1 1 2 2|
Hepatocyte, Hyperplasia | 1 3 2 |
__________________________________________________________________________|
Mesentery | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + A + + + +|
Atrophy | 1 2 1 2 1 1 1 2 |
Cytomegaly | 1 |
Inflammation | 1 |
Pigmentation, Hemosiderin | |
Perivascular, Inflammation | 3 |
__________________________________________________________________________|
Pharynx | + |
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Hyperplasia | 1 1 1 1 1 1 1 1 |
Duct, Inflammation, Suppurative | 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
Inflammation, Suppurative | 2 |
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05078-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:29:24
_____________________________________________________________________________________________________________________
| 7| 4| 6| 5| 7| 7| 7| 7| 6| 6| 7| 7| 6| 5| 7| 6| 5| 6| 6| 5| 7| 6| 7| 5| 7|
DAY ON TEST | 2| 7| 7| 5| 2| 1| 2| 0| 2| 6| 2| 2| 8| 8| 0| 4| 8| 2| 1| 4| 2| 3| 1| 1| 0|
| 9| 9| 1| 2| 9| 6| 9| 9| 6| 4| 9| 9| 9| 1| 1| 6| 7| 1| 1| 9| 7| 3| 3| 9| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
15000 PP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
M | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Ulcer | 3 |
Epithelium, Hyperplasia | 3 |
Serosa, Inflammation, Chronic | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 1 1 2 |
Hyperplasia, Lymphoid | |
Mineralization | 3 |
Epithelium, Hyperplasia | |
Serosa, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 1 2 2 2 2 3 1 2 1 2 2 2 2 1 3 2 1 2 2 2 3 2 2|
Artery, Mineralization | 2 |
Atrium, Thrombosis | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Fatty | 1 1 2 2 1 1 2 2 2 1 1 1 1 2 2 1|
Hematopoietic Cell Proliferation | 1 |
Hyperplasia | 4 3 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + M + + + + + + +|
Hematopoietic Cell Proliferation | 1 |
Hyperplasia | 4 1 1 2 1 1 2 4 3 2 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + A + + + +|
Hyperplasia | 3 1 1 |
__________________________________________________________________________|
Parathyroid Gland | + M + + + + + + + + + + + + + + M + M M + + + + +|
Hyperplasia | 2 3 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | X |
Pars Distalis, Hemorrhage | |
Pars Distalis, Hyperplasia | 3 1 2 |
Pars Distalis, Inflammation, | |
Suppurative | |
Pars Distalis, Pigmentation, | |
Hemosiderin | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + M A + + + +|
C-Cell, Hyperplasia | 1 1 1 3 1 2 1 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
Inflammation, Chronic | |
Necrosis | |
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05078-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:29:24
_____________________________________________________________________________________________________________________
| 7| 4| 6| 5| 7| 7| 7| 7| 6| 6| 7| 7| 6| 5| 7| 6| 5| 6| 6| 5| 7| 6| 7| 5| 7|
DAY ON TEST | 2| 7| 7| 5| 2| 1| 2| 0| 2| 6| 2| 2| 8| 8| 0| 4| 8| 2| 1| 4| 2| 3| 1| 1| 0|
| 9| 9| 1| 2| 9| 6| 9| 9| 6| 4| 9| 9| 9| 1| 1| 6| 7| 1| 1| 9| 7| 3| 3| 9| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
15000 PP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
M | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + M + + + M + M + + + + + + + + + + + + M +|
Granuloma Sperm | |
Vacuolization Cytoplasmic | 2 1 2 1 1 2 2 2 2 2 |
__________________________________________________________________________|
Penis | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Preputial Gland | M + + + + + + + M + + + + + + M + M + + + + + + +|
Cyst | 3 |
Inflammation, Suppurative | 2 1 |
Duct, Hyperplasia | |
__________________________________________________________________________|
Prostate | + M + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 2 2 1 2 |
Inflammation, Suppurative | 1 1 2 1 3 2 2|
__________________________________________________________________________|
Seminal Vesicle | + + + + |
Inflammation, Suppurative | 1 1 1 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 4 2 1 2 4 2 2 2 2 2 3 2 3 3|
Interstitial Cell, Hyperplasia | 3 1 2 2 1|
Perivascular, Inflammation | 3 2 2 3 2 2 |
Tunic, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + A + + + +|
Hyperplasia | 2 |
Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mesenteric, Inflammation, | |
Granulomatous | 1 |
__________________________________________________________________________|
Lymph Node, Bronchial | M + + + + + + + + + + + + + + + + + + + M + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + M M + + + + + M + + + + + + + I +|
Angiectasis | |
Hyperplasia | 3 2 2 2 2 3 2|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 1 2 2 2 1 2|
Hematocyst | 3|
Hematopoietic Cell Proliferation | 3 |
__________________________________________________________________________|
Thymus | + + + + + + M + + + M + + + + + + + + + + M + + M|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M + M M M M M M M + M M + + M M + + M M + + M M|
Galactocele | 1 1 |
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05078-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:29:24
_____________________________________________________________________________________________________________________
| 7| 4| 6| 5| 7| 7| 7| 7| 6| 6| 7| 7| 6| 5| 7| 6| 5| 6| 6| 5| 7| 6| 7| 5| 7|
DAY ON TEST | 2| 7| 7| 5| 2| 1| 2| 0| 2| 6| 2| 2| 8| 8| 0| 4| 8| 2| 1| 4| 2| 3| 1| 1| 0|
| 9| 9| 1| 2| 9| 6| 9| 9| 6| 4| 9| 9| 9| 1| 1| 6| 7| 1| 1| 9| 7| 3| 3| 9| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
15000 PP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
M | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Hyperplasia | 2 1 1 1 2 1 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + M + + + + + + + +|
Ectopic Tissue | |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 2 2 |
Hyperostosis | 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Focal | 1 |
Meninges, Pigmentation, Hemosiderin | 1 |
__________________________________________________________________________|
Spinal Cord | |
Degeneration | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + I + + + + + + + + + + A + + A + + I +|
Inflammation, Suppurative | 2 2 1 1 2 1 1 1 1 1 1 1|
Metaplasia, Squamous | 1 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 2 3 3 |
Edema | 2 3 |
Erythrophagocytosis | 2 |
Hemorrhage | 3 1 2 |
Infiltration Cellular, Histiocyte | 2 2 2|
Infiltration Cellular, Mixed Cell | |
Inflammation, Chronic, Focal | 2 2|
Metaplasia, Osseous | 1 1 |
Alveolar Epithelium, Hyperplasia | 2 1 4 |
Artery, Mediastinum, Mineralization | 2 |
Bronchiole, Inflammation, Suppurative| 2 |
Perivascular, Infiltration Cellular, | |
Mononuclear Cell | 1 1 1 2 1 1 1 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + A + + + +|
Inflammation, Suppurative | 2 1 1 1 1 1 1 2 |
Thrombosis | 3 2 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 2 1 4 |
Respiratory Epithelium, Hyperplasia | 1 1 1 1 1 1 |
Submucosa, Inflammation | 2 1 2 2 1 1 2 2 1 2 3 2 |
Vomeronasal Organ, Inflammation, | |
Suppurative | 1 |
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05078-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:29:24
_____________________________________________________________________________________________________________________
| 7| 4| 6| 5| 7| 7| 7| 7| 6| 6| 7| 7| 6| 5| 7| 6| 5| 6| 6| 5| 7| 6| 7| 5| 7|
DAY ON TEST | 2| 7| 7| 5| 2| 1| 2| 0| 2| 6| 2| 2| 8| 8| 0| 4| 8| 2| 1| 4| 2| 3| 1| 1| 0|
| 9| 9| 1| 2| 9| 6| 9| 9| 6| 4| 9| 9| 9| 1| 1| 6| 7| 1| 1| 9| 7| 3| 3| 9| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
15000 PP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
M | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + A + + + + + + +|
Inflammation, Suppurative | 1 1 1 2 |
Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + + |
Cataract | |
Degeneration | 4 |
Inflammation, Chronic | |
Synechia | 2 3 |
Bilateral, Cataract | 3 2 |
Retina, Atrophy | 4 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 |
Hydronephrosis | |
Inflammation, Suppurative | 1 2 2 |
Nephropathy | 3 2 3 1 3 3 3 3 3 3 4 4 4 2 3 4 2 1 3 2 3 1 4 3 3|
Pelvis, Epithelium, Hyperplasia | 2 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + M + + + + + + +|
Hemorrhage | |
Inflammation | |
Inflammation, Suppurative | 1 |
Transitional Epithelium, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 05078-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:29:24
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 5| 6| 6| 7| 7| 7| 5| 7| 6| 7| 6| 6| 7| 5| 6| 6| 5| 4| 5| 6| 4| |
DAY ON TEST | 2| 1| 0| 0| 7| 7| 2| 2| 2| 2| 7| 0| 0| 1| 1| 7| 0| 2| 4| 2| 6| 3| 8| 0| 7| |
| 8| 4| 7| 0| 7| 8| 6| 9| 9| 9| 7| 4| 2| 7| 3| 8| 9| 6| 6| 6| 2| 7| 7| 8| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
15000 PP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
M | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + M + + + + + + + + + + + M M + + + + +| 43 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + A + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + M + + + + A + + +| 45 |
Parasite Metazoan | X X | 4 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + A + A + + +| 45 |
Parasite Metazoan | X X X | 5 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + M + + + + + + + + + + + M + + + + + + M + + +| 43 |
Parasite Metazoan | X X X | 5 |
Serosa, Inflammation, Chronic | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | M + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + M + + + + + + + M + + + + M + + + + A + + +| 40 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + A + + +| 45 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 3.0|
Basophilic Focus | 1 1 1 | 7 1.0|
Clear Cell Focus | 1 | 2 1.0|
Congestion | | 2 3.0|
Degeneration, Cystic | 1 2 1 1 | 9 1.6|
Degeneration, Fatty | 1 2 | 5 1.6|
Degeneration | 2 | 2 2.0|
Hematopoietic Cell Proliferation | 1 | 3 1.3|
Hepatodiaphragmatic Nodule | X | 2 |
Inflammation, Focal, Granulomatous | 2 1 1 1| 5 1.4|
Necrosis | 1 2 2 | 4 1.8|
Pigmentation | 2 | 1 2.0|
Bile Duct, Hyperplasia | 1 2 3 1 2 1 2 2 2 2 2 2 1 1 2 3 1| 34 1.7|
Hepatocyte, Hyperplasia | 2 4 2 3 2 | 8 2.4|
__________________________________________________________________________|____________|
Mesentery | + | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | 1 2 1 1 1 1 2 2 4 | 17 1.5|
Cytomegaly | | 1 1.0|
Inflammation | | 1 1.0|
Pigmentation, Hemosiderin | 2 | 1 2.0|
Perivascular, Inflammation | 2 1 | 3 2.0|
__________________________________________________________________________|____________|
Pharynx | | 1 |
Inflammation, Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Duct, Hyperplasia | 1 1 1 1 1 1 1 | 15 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 36
NTP Experiment-Test: 05078-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:29:24
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 5| 6| 6| 7| 7| 7| 5| 7| 6| 7| 6| 6| 7| 5| 6| 6| 5| 4| 5| 6| 4| |
DAY ON TEST | 2| 1| 0| 0| 7| 7| 2| 2| 2| 2| 7| 0| 0| 1| 1| 7| 0| 2| 4| 2| 6| 3| 8| 0| 7| |
| 8| 4| 7| 0| 7| 8| 6| 9| 9| 9| 7| 4| 2| 7| 3| 8| 9| 6| 6| 6| 2| 7| 7| 8| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
15000 PP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
M | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Duct, Inflammation, Suppurative | | 1 1.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + M + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperkeratosis | 2 | 1 2.0|
Inflammation, Suppurative | | 1 2.0|
Ulcer | | 1 3.0|
Epithelium, Hyperplasia | 4 | 2 3.5|
Serosa, Inflammation, Chronic | 4 | 1 4.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion | | 3 1.3|
Hyperplasia, Lymphoid | 2 | 1 2.0|
Mineralization | 2 | 2 2.5|
Epithelium, Hyperplasia | 1 | 1 1.0|
Serosa, Inflammation, Chronic | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 1 1 1 1 2 2 3 2 2 2 2 3 1 3 2 2 2 1 2 3 1 1| 46 1.9|
Artery, Mineralization | | 1 2.0|
Atrium, Thrombosis | 3 | 2 2.5|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Fatty | 1 2 3 2 1 1 2 1 1 2 | 26 1.5|
Hematopoietic Cell Proliferation | 2 | 2 1.5|
Hyperplasia | 1 2 3 | 6 2.5|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + M + + + + + + + + + + + + + + + +| 48 |
Hematopoietic Cell Proliferation | | 1 1.0|
Hyperplasia | 2 2 3 3 3 | 16 2.3|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + M + + + + +| 48 |
Hyperplasia | 2 | 4 1.8|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + M + + + + + + + + + M + M + + + M + M| 41 |
Hyperplasia | 1 | 3 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Cyst | 2 | 2 2.0|
Pars Distalis, Hemorrhage | 2 | 1 2.0|
Pars Distalis, Hyperplasia | 4 2 2 2 4 1 2 | 10 2.3|
Pars Distalis, Inflammation, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 37
NTP Experiment-Test: 05078-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:29:24
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 5| 6| 6| 7| 7| 7| 5| 7| 6| 7| 6| 6| 7| 5| 6| 6| 5| 4| 5| 6| 4| |
DAY ON TEST | 2| 1| 0| 0| 7| 7| 2| 2| 2| 2| 7| 0| 0| 1| 1| 7| 0| 2| 4| 2| 6| 3| 8| 0| 7| |
| 8| 4| 7| 0| 7| 8| 6| 9| 9| 9| 7| 4| 2| 7| 3| 8| 9| 6| 6| 6| 2| 7| 7| 8| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
15000 PP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
M | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Suppurative | 2 | 1 2.0|
Pars Distalis, Pigmentation, | | |
Hemosiderin | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + M| 47 |
C-Cell, Hyperplasia | 1 3 1 1 1 1 3 4 1 2 2 2 1 | 23 1.6|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + + +| 4 |
Inflammation, Chronic | 3 | 1 3.0|
Necrosis | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + M M + + I + + + + + + + + + M + + +| 42 |
Granuloma Sperm | 2| 1 2.0|
Vacuolization Cytoplasmic | 1 2 3 3 2 | 15 1.9|
__________________________________________________________________________|____________|
Penis | + | 1 |
Inflammation, Suppurative | 2 | 1 2.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + M + + + + + + + + + + + + + + +| 45 |
Cyst | | 1 3.0|
Inflammation, Suppurative | 1 | 3 1.3|
Duct, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + I + + + + +| 48 |
Hyperplasia | 1 1 1 2 1 | 11 1.5|
Inflammation, Suppurative | 2 2 1 2 2 1 | 13 1.7|
__________________________________________________________________________|____________|
Seminal Vesicle | + +| 6 |
Inflammation, Suppurative | 3 | 5 1.6|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 3 2 4 4 1 4 1 4 2 3 3 4 3| 29 2.7|
Interstitial Cell, Hyperplasia | 1 1 1 1 2 1 1 1 1 1 | 15 1.3|
Perivascular, Inflammation | 1 2 | 8 2.1|
Tunic, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + + + | 4 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + M + + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia | | 1 2.0|
Myelofibrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mesenteric, Inflammation, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 38
NTP Experiment-Test: 05078-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:29:24
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 5| 6| 6| 7| 7| 7| 5| 7| 6| 7| 6| 6| 7| 5| 6| 6| 5| 4| 5| 6| 4| |
DAY ON TEST | 2| 1| 0| 0| 7| 7| 2| 2| 2| 2| 7| 0| 0| 1| 1| 7| 0| 2| 4| 2| 6| 3| 8| 0| 7| |
| 8| 4| 7| 0| 7| 8| 6| 9| 9| 9| 7| 4| 2| 7| 3| 8| 9| 6| 6| 6| 2| 7| 7| 8| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
15000 PP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
M | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Granulomatous | | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia | 2| 2 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + M M M + M + + + + + + + + M + M M + + + M| 38 |
Angiectasis | 2 2 | 2 2.0|
Hyperplasia | 2 2 2 1 | 11 2.1|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 2 2 1 | 9 1.7|
Hematocyst | | 1 3.0|
Hematopoietic Cell Proliferation | 2 | 2 2.5|
__________________________________________________________________________|____________|
Thymus | I + M + + M + + + M + + + + + + M + + + + + + + +| 41 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M + + M M M M M M M M M + + M M M M M M + M + M M| 14 |
Galactocele | 1 | 3 1.0|
Hyperplasia | 1 1 2 1 | 10 1.3|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + M M + + + + + + + + + + + M + +| 46 |
Ectopic Tissue | X | 1 |
Inflammation, Chronic | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Fibrous Osteodystrophy | 2 2 | 4 2.0|
Hyperostosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage, Focal | 1 3 | 3 1.7|
Meninges, Pigmentation, Hemosiderin | | 1 1.0|
__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
Degeneration | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + I + + + + + +| 44 |
Inflammation, Suppurative | 1 1 1 1 1 1 2 1 1 | 21 1.2|
Metaplasia, Squamous | | 1 1.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 3 | 5 2.8|
Edema | | 2 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 39
NTP Experiment-Test: 05078-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:29:24
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 5| 6| 6| 7| 7| 7| 5| 7| 6| 7| 6| 6| 7| 5| 6| 6| 5| 4| 5| 6| 4| |
DAY ON TEST | 2| 1| 0| 0| 7| 7| 2| 2| 2| 2| 7| 0| 0| 1| 1| 7| 0| 2| 4| 2| 6| 3| 8| 0| 7| |
| 8| 4| 7| 0| 7| 8| 6| 9| 9| 9| 7| 4| 2| 7| 3| 8| 9| 6| 6| 6| 2| 7| 7| 8| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
15000 PP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
M | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Erythrophagocytosis | | 1 2.0|
Hemorrhage | | 3 2.0|
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 2 1 3 1 | 13 1.5|
Infiltration Cellular, Mixed Cell | 2 | 1 2.0|
Inflammation, Chronic, Focal | | 2 2.0|
Metaplasia, Osseous | | 2 1.0|
Alveolar Epithelium, Hyperplasia | 4 4 2 4 | 7 3.0|
Artery, Mediastinum, Mineralization | | 1 2.0|
Bronchiole, Inflammation, Suppurative| | 1 2.0|
Perivascular, Infiltration Cellular, | | |
Mononuclear Cell | 1 1 1 1 1 1 | 14 1.1|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Suppurative | 1 1 1 1 2| 13 1.2|
Thrombosis | 1 2 2 2 1| 7 1.9|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 2 1 2 1 | 8 1.9|
Respiratory Epithelium, Hyperplasia | 1 1 1 1 2 1 1 1| 14 1.1|
Submucosa, Inflammation | 2 1 2 1 2 1 1 2 1 1 2| 23 1.6|
Vomeronasal Organ, Inflammation, | | |
Suppurative | | 1 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Suppurative | 1 1 1 | 7 1.1|
Epithelium, Hyperplasia | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + + | 7 |
Cataract | 3 | 1 3.0|
Degeneration | | 1 4.0|
Inflammation, Chronic | 4 | 1 4.0|
Synechia | 3 4 | 4 3.0|
Bilateral, Cataract | 3 | 3 2.7|
Retina, Atrophy | 3 4 | 3 3.7|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 1 1 | 3 1.3|
Hydronephrosis | 2| 1 2.0|
Inflammation, Suppurative | | 3 1.7|
Nephropathy | 3 2 2 2 2 4 3 4 4 2 2 1 3 2 3 3 2 2 3 2 2 3 2 1| 49 2.6|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 40
NTP Experiment-Test: 05078-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC ETHYL CHLORIDE Date: 05/05/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 15:29:24
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 5| 6| 6| 7| 7| 7| 5| 7| 6| 7| 6| 6| 7| 5| 6| 6| 5| 4| 5| 6| 4| |
DAY ON TEST | 2| 1| 0| 0| 7| 7| 2| 2| 2| 2| 7| 0| 0| 1| 1| 7| 0| 2| 4| 2| 6| 3| 8| 0| 7| |
| 8| 4| 7| 0| 7| 8| 6| 9| 9| 9| 7| 4| 2| 7| 3| 8| 9| 6| 6| 6| 2| 7| 7| 8| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
15000 PP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
M | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Pelvis, Epithelium, Hyperplasia | 2 | 3 2.3|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hemorrhage | 2 | 1 2.0|
Inflammation | 2 | 1 2.0|
Inflammation, Suppurative | | 1 1.0|
Transitional Epithelium, Hyperplasia | 2 | 2 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 41
------------------------------------------------------------
---------- END OF REPORT ----------
------------------------------------------------------------
--multipart-boundary
Content-type: text/plain
Range: bytes 379923-379923/379923
--multipart-boundary--