National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/2483

TR 346 Rat Pathology Tables

NTP Experiment-Test: 05078-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 05/05/97
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:29:24




       Facility:  Battelle Northwest

       Chemical CAS #:  75-00-3

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All






































                                                              Page   1

NTP Experiment-Test: 05078-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 05/05/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:29:24  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 2| 7| 6| 7| 6| 7| 7| 6| 6| 6| 7| 7|             
                             DAY ON TEST   | 2| 1| 6| 2| 2| 2| 2| 2| 1| 2| 2| 2| 6| 5| 2| 5| 2| 5| 2| 2| 5| 3| 5| 2| 2|             
                                           | 9| 1| 8| 9| 9| 9| 9| 9| 6| 9| 9| 9| 8| 1| 9| 9| 9| 4| 9| 9| 9| 3| 7| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                X                                X     X  X              X|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |             X                                                            |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  I  +  +  +|             
      Parasite Metazoan                    |                X              X                 X                        |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     |    1  1  1  1  1  1  1     2  2     1     1           1           1  1  1|             
      Degeneration, Fatty                  | 2                       1              3     2              3  2         |             
      Degeneration                         |                                                    2                     |             
      Hematopoietic Cell Proliferation     |                                     1                                    |             
      Hepatodiaphragmatic Nodule           |                                  X                       X               |             
      Inflammation, Focal, Granulomatous   |    1     2  2  1  1  1        1                       1  1               |             
      Leukocytosis                         |                      2                                               1   |             
      Necrosis                             |       1              1                                                   |             
      Thrombosis                           |                                                                          |             
      Bile Duct, Hyperplasia               |                               1           1        1           1         |             
      Hepatocyte, Hyperplasia              |                            3                                             |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Fat, Inflammation, Chronic           |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |    1     2     1              1                    2     2  2            |             
      Cytomegaly                           |                                                                         1|             
      Inflammation                         |                                                          2               |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic, Suppurative   |                                  2                                       |             
      Duct, Hyperplasia                    |                                                 1                 1     1|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                2         |             
      Inflammation, Suppurative            |                                                                          |             
      Ulcer                                |                                                                          |             
      Epithelium, Hyperplasia              |                                        2                       3         |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05078-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 05/05/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:29:24  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 2| 7| 6| 7| 6| 7| 7| 6| 6| 6| 7| 7|             
                             DAY ON TEST   | 2| 1| 6| 2| 2| 2| 2| 2| 1| 2| 2| 2| 6| 5| 2| 5| 2| 5| 2| 2| 5| 3| 5| 2| 2|             
                                           | 9| 1| 8| 9| 9| 9| 9| 9| 6| 9| 9| 9| 8| 1| 9| 9| 9| 4| 9| 9| 9| 3| 7| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                | 2  1  2  1  2  2  2  2  1     2  1        2  2  1  1  1  2     1     2  1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Fatty                  |    1        2              1                       1  2  3     3         |             
      Focal Cellular Change                |                                                       2                  |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia                          | 2                             3  2        2                              |             
      Hypertrophy                          |                                                                          |             
      Necrosis                             |       2                                                                  |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | M  M  +  +  +  M  +  +  +  +  +  I  +  +  +  +  M  +  +  +  M  +  +  M  M|             
      Hyperplasia                          |                      3                                                   |             
      Necrosis                             |                         2                                                |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |          1                                                               |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  M  +  +  +  +  +  +  +  I  +  M  M  +  +  +  M  +  M  +  M  +  M  M  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |       2                                                                  |             
      Pars Distalis, Hyperplasia           |       1  3           2     2  2                                          |             
      Pars Distalis, Metaplasia, Osseous   |                                                          3               |             
      Pars Distalis, Pigmentation,         |                                                                          |             
          Hemosiderin                      |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |       2  1  3  1  2  2  3  3  1     1     1     1  2           1  2  1  2|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  M  +  +|             
      Cyst                                 |                                              3                           |             
      Hyperplasia                          |                                              2                           |             
      Inflammation, Suppurative            |    1                                         2                 1         |             
      Duct, Hyperplasia                    |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Atrophy                              |                         2                                                |             
      Cyst                                 |                                                          X               |             
      Interstitium, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Hemorrhage                           |                         4                                                |             
      Inflammation, Suppurative            |                                                                          |             
      Endometrium, Hyperplasia, Cystic     |                                                    1                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05078-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 05/05/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:29:24  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 2| 7| 6| 7| 6| 7| 7| 6| 6| 6| 7| 7|             
                             DAY ON TEST   | 2| 1| 6| 2| 2| 2| 2| 2| 1| 2| 2| 2| 6| 5| 2| 5| 2| 5| 2| 2| 5| 3| 5| 2| 2|             
                                           | 9| 1| 8| 9| 9| 9| 9| 9| 6| 9| 9| 9| 8| 1| 9| 9| 9| 4| 9| 9| 9| 3| 7| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Endometrium, Hyperplasia             |                                                                   2      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myelofibrosis                        |       2                                                                  |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Mesenteric, Angiectasis              |                                                                          |             
      Mesenteric, Inflammation,            |                                                                          |             
          Granulomatous                    |                                                                          |             
      Renal, Inflammation, Granulomatous   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +|             
      Congestion                           |                                                                          |             
      Hyperplasia                          |             2                                                            |             
      Inflammation, Granulomatous          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  M  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  M  I  M  +|             
      Angiectasis                          |                                                                          |             
      Hyperplasia                          |                         2        2                                      2|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Inflammation, Focal, Granulomatous   |                               1                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +  +  +  +  +  M  +  M  +  +  +  +  +  M  +  +  M  +  +  M  +  +  I|             
      Epithelial Cell, Hyperplasia         |                               1                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +|             
      Hyperplasia                          | 2  2  2  2     1  2  2  2  2  2  2        1  2     2  2  2     2  2  2  1|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Acanthosis                           |                                     2                                    |             
      Inflammation                         |                                     1                                    |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic                         |                                                                          |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Granulomatous                   |          2                                                               |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage, Focal                    |                                                                          |             
      Necrosis, Focal                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05078-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 05/05/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:29:24  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 2| 7| 6| 7| 6| 7| 7| 6| 6| 6| 7| 7|             
                             DAY ON TEST   | 2| 1| 6| 2| 2| 2| 2| 2| 1| 2| 2| 2| 6| 5| 2| 5| 2| 5| 2| 2| 5| 3| 5| 2| 2|             
                                           | 9| 1| 8| 9| 9| 9| 9| 9| 6| 9| 9| 9| 8| 1| 9| 9| 9| 4| 9| 9| 9| 3| 7| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            | 2                                                        1     1         |             
      Metaplasia, Squamous                 |                                                                          |             
      Submucosa, Inflammation              |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                   2      |             
      Foreign Body                         |                                                    1                     |             
      Infiltration Cellular, Histiocyte    |    1                                            2                 2      |             
      Inflammation, Chronic, Diffuse       |                                                                          |             
      Inflammation, Chronic, Focal         |                      1                          3  2                     |             
      Inflammation, Granulomatous          |                                                    2                     |             
      Alveolar Epithelium, Hyperplasia     |                                                 1                        |             
      Mediastinum, Infiltration Cellular,  |                                                                          |             
           Mononuclear Cell                |          2                                                               |             
      Perivascular, Infiltration Cellular, |                                                                          |             
           Mononuclear Cell                |    2           2  1        1  1  2  1                    1           2   |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |          1                                         2                    2|             
      Thrombosis                           |       2                                                                  |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |             1           3  2           1     1                 3         |             
      Respiratory Epithelium, Hyperplasia  |                                                    2                    2|             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                                                    3                    1|             
      Submucosa, Inflammation              |             2        1        2  1  1     1     1  3  1  2              3|             
      Vomeronasal Organ, Inflammation,     |                                                                          |             
           Suppurative                     |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                        1                                 |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                         +|             
      Cataract                             |                                                                          |             
      Synechia                             |                                                                          |             
      Bilateral, Cataract                  |                                                                         3|             
      Retina, Atrophy                      |                                                                         3|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |       2                                                                  |             
      Nephropathy                          | 2  3  2  2  3  1  2  2  3  2  2  3        2  2  1  2  1  3  1  4  2  3  2|             
      Renal Tubule, Hyperplasia, Focal     |                                                                      2   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05078-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 05/05/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:29:24  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 7| 7| 7| 7| 6| 7| 5| 5| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 5| 7| 7| 7|            |
                             DAY ON TEST   | 6| 3| 2| 2| 2| 2| 2| 8| 2| 8| 4| 2| 2| 2| 2| 4| 2| 0| 7| 2| 2| 4| 2| 2| 2|            |
                                           | 1| 0| 9| 9| 9| 9| 9| 8| 9| 7| 0| 9| 9| 9| 9| 3| 9| 3| 4| 9| 9| 5| 9| 9| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |          X                                                     X         |      7     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |          X        X                             X                        |      4     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Parasite Metazoan                    |          X     X                                            X            |      6     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                      3                                                   |      1  3.0|
      Basophilic Focus                     | 1     2     1  2  1  1  1           1     1     1        2  2     1  1   |     29  1.2|
      Degeneration, Fatty                  |    3        2                          2              3                  |     10  2.3|
      Degeneration                         | 2                                                                        |      2  2.0|
      Hematopoietic Cell Proliferation     |                      2                                      1            |      3  1.3|
      Hepatodiaphragmatic Nodule           |                                  X                                       |      3     |
      Inflammation, Focal, Granulomatous   |                2  2     2     1  1  1        1           2     1     1   |     19  1.3|
      Leukocytosis                         |                   2                                                      |      3  1.7|
      Necrosis                             |                                                                          |      2  1.0|
      Thrombosis                           |                                        3  1                              |      2  2.0|
      Bile Duct, Hyperplasia               | 2        2     1                                                         |      7  1.3|
      Hepatocyte, Hyperplasia              |          4                                                               |      2  3.5|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                       +                  |   1        |
      Fat, Inflammation, Chronic           |                                                       2                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +|  49        |
      Atrophy                              |                1     1  2     1        3     1     1                 1   |     15  1.5|
      Cytomegaly                           |                                                                          |      1  1.0|
      Inflammation                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Inflammation, Chronic, Suppurative   |                                                                          |      1  2.0|
      Duct, Hyperplasia                    |                                        2                                 |      4  1.3|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|  46        |
      Inflammation, Chronic                |                            2                                             |      2  2.0|
      Inflammation, Suppurative            |                                                       3                  |      1  3.0|
      Ulcer                                |                                                       3                  |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   6                                                               
NTP Experiment-Test: 05078-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 05/05/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:29:24  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 7| 7| 7| 7| 6| 7| 5| 5| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 5| 7| 7| 7|            |
                             DAY ON TEST   | 6| 3| 2| 2| 2| 2| 2| 8| 2| 8| 4| 2| 2| 2| 2| 4| 2| 0| 7| 2| 2| 4| 2| 2| 2|            |
                                           | 1| 0| 9| 9| 9| 9| 9| 8| 9| 7| 0| 9| 9| 9| 9| 3| 9| 3| 4| 9| 9| 5| 9| 9| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Epithelium, Hyperplasia              |                            3                       1  3              2   |      6  2.3|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Tongue                                  |                      +                                                   |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                | 2  1  1  1  2  2  2  2  1  1     2  3  2  1     2  1     2  2  1  2  2  2|     42  1.6|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Degeneration, Fatty                  |       1           1        1                          3        1        2|     13  1.7|
      Focal Cellular Change                |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |    2        2        2                                3                 1|      5  2.0|
      Hyperplasia                          |                                     2                          2         |      6  2.2|
      Hypertrophy                          |                                                          3               |      1  3.0|
      Necrosis                             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  M  +  M  +  +  +  +  +  +  I  +  +  +  M  +  +  +  I  +  +  M  I|  35        |
      Hyperplasia                          |                                  1                 1              3      |      4  2.0|
      Necrosis                             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|  49        |
      Hyperplasia                          |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  M  +  +  +  +  +  +  +  M  M  M  +  +  +  +  +  +  +  +  M  +  M  +|  34        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Pars Distalis, Cyst                  |          X              4                                                |      3  3.0|
      Pars Distalis, Hyperplasia           | 2     2        3        1           2                                    |     10  2.0|
      Pars Distalis, Metaplasia, Osseous   |                                                                          |      1  3.0|
      Pars Distalis, Pigmentation,         |                                                                          |            |
          Hemosiderin                      | 2                                                                        |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      C-Cell, Hyperplasia                  | 2  2     1     3     2     1     1  1     2  2  2  2  1        1     1  1|     33  1.6|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                      +                                                   |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Cyst                                 | 3                                                                        |      2  3.0|
      Hyperplasia                          |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   7                                                               
NTP Experiment-Test: 05078-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 05/05/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:29:24  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 7| 7| 7| 7| 6| 7| 5| 5| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 5| 7| 7| 7|            |
                             DAY ON TEST   | 6| 3| 2| 2| 2| 2| 2| 8| 2| 8| 4| 2| 2| 2| 2| 4| 2| 0| 7| 2| 2| 4| 2| 2| 2|            |
                                           | 1| 0| 9| 9| 9| 9| 9| 8| 9| 7| 0| 9| 9| 9| 9| 3| 9| 3| 4| 9| 9| 5| 9| 9| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Suppurative            |                                        2                                 |      4  1.5|
      Duct, Hyperplasia                    | 3                                                                        |      1  3.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atrophy                              |                                                                          |      1  2.0|
      Cyst                                 |                                                 2                        |      2  2.0|
      Interstitium, Hyperplasia            |                                                    2              1      |      2  1.5|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hemorrhage                           |                                                                          |      1  4.0|
      Inflammation, Suppurative            |                                                       1                  |      1  1.0|
      Endometrium, Hyperplasia, Cystic     |                                                                          |      1  1.0|
      Endometrium, Hyperplasia             |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Myelofibrosis                        | 2                                                                        |      2  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|  48        |
      Mesenteric, Angiectasis              |                                                                2         |      1  2.0|
      Mesenteric, Inflammation,            |                                                                          |            |
          Granulomatous                    |                                                                2         |      1  2.0|
      Renal, Inflammation, Granulomatous   |                               2                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|  47        |
      Congestion                           |                      4                                                   |      1  4.0|
      Hyperplasia                          |                                                                          |      1  2.0|
      Inflammation, Granulomatous          |                                                                      2   |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  M  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  M  M  +  +  +|  39        |
      Angiectasis                          |                         2                                                |      1  2.0|
      Hyperplasia                          |       2              2                 2        2        3              2|      9  2.1|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             |                            2                                             |      1  2.0|
      Hematopoietic Cell Proliferation     |                      2                                                   |      1  2.0|
      Inflammation, Focal, Granulomatous   |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  M  M  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  M|  38        |
      Epithelial Cell, Hyperplasia         |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hyperplasia                          | 2  1  1  1  2  2  1  2  2  2  1  1  1  2  2  1  2  2  1  2  1  2  2  2  1|     45  1.7|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Acanthosis                           | 3                                                                        |      2  2.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   8                                                               
NTP Experiment-Test: 05078-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 05/05/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:29:24  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 7| 7| 7| 7| 6| 7| 5| 5| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 5| 7| 7| 7|            |
                             DAY ON TEST   | 6| 3| 2| 2| 2| 2| 2| 8| 2| 8| 4| 2| 2| 2| 2| 4| 2| 0| 7| 2| 2| 4| 2| 2| 2|            |
                                           | 1| 0| 9| 9| 9| 9| 9| 8| 9| 7| 0| 9| 9| 9| 9| 3| 9| 3| 4| 9| 9| 5| 9| 9| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Inflammation                         |                                                                          |      1  1.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Chronic                         |                                                    2                     |      1  2.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Granulomatous                   |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage, Focal                    |                                                    2  2                  |      2  2.0|
      Necrosis, Focal                      |                                                       2                  |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            | 1     1           1     2                 1        2                    1|     10  1.3|
      Metaplasia, Squamous                 |                                                                1         |      1  1.0|
      Submucosa, Inflammation              |                                                                2         |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |                                                                          |      1  2.0|
      Foreign Body                         |                                                                          |      1  1.0|
      Infiltration Cellular, Histiocyte    |             2  1           2                                2        1   |      8  1.6|
      Inflammation, Chronic, Diffuse       |                                                             2            |      1  2.0|
      Inflammation, Chronic, Focal         |             2                                                            |      4  2.0|
      Inflammation, Granulomatous          |                                                                          |      1  2.0|
      Alveolar Epithelium, Hyperplasia     |             2  1                                                  4      |      4  2.0|
      Mediastinum, Infiltration Cellular,  |                                                                          |            |
           Mononuclear Cell                |                                                                          |      1  2.0|
      Perivascular, Infiltration Cellular, |                                                                          |            |
           Mononuclear Cell                |       1        2  2  1  1     1  2           1  1        1        1  1   |     21  1.3|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |                      1                       1     1                     |      6  1.3|
      Thrombosis                           |    3                                                                     |      2  2.5|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |                      1           3     1           1                 1  1|     12  1.6|
      Respiratory Epithelium, Hyperplasia  |                            1                             1               |      4  1.5|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        |                                                                          |      2  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   9                                                               
NTP Experiment-Test: 05078-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 05/05/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:29:24  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 7| 7| 7| 7| 6| 7| 5| 5| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 5| 7| 7| 7|            |
                             DAY ON TEST   | 6| 3| 2| 2| 2| 2| 2| 8| 2| 8| 4| 2| 2| 2| 2| 4| 2| 0| 7| 2| 2| 4| 2| 2| 2|            |
                                           | 1| 0| 9| 9| 9| 9| 9| 8| 9| 7| 0| 9| 9| 9| 9| 3| 9| 3| 4| 9| 9| 5| 9| 9| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Submucosa, Inflammation              |       1  1        2  1  2     3  2        2     2  1     2     1  1     1|     25  1.6|
      Vomeronasal Organ, Inflammation,     |                                                                          |            |
           Suppurative                     |                                                    1                     |      1  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |                                                    1                     |      2  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                  +  M                          +         |   3        |
      Cataract                             |                                  2                                       |      1  2.0|
      Synechia                             |                                                                2         |      1  2.0|
      Bilateral, Cataract                  |                                                                          |      1  3.0|
      Retina, Atrophy                      |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |                      1                                                   |      2  1.5|
      Nephropathy                          | 2  1  2  2  2  1  3  3  3  1     3  3  1  1  3  2  2  1  2  3  3  3  3  2|     47  2.2|
      Renal Tubule, Hyperplasia, Focal     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  10                                                               
NTP Experiment-Test: 05078-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 05/05/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:29:24  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 5| 7| 6| 5| 5| 7| 7| 7| 6| 6| 5| 5| 7| 6| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 2| 2| 3| 8| 9| 0| 8| 7| 5| 3| 3| 3| 8| 1| 9| 7| 3| 5| 3|             
                                           | 0| 0| 0| 0| 0| 0| 0| 3| 0| 8| 4| 7| 9| 4| 9| 0| 0| 0| 8| 2| 9| 3| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    15000 PP                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    M                                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Anus, Parasite Metazoan              |                                                                X         |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Parasite Metazoan                    | X                                                                        |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Parasite Metazoan                    |                                  X              X                        |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  A  M  +  +  +|             
      Parasite Metazoan                    |       X     X                 X                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  A  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     | 1           2  1  1  1  1        1                 2           1     2  2|             
      Congestion                           |                   2                                                      |             
      Degeneration, Fatty                  |                   2              2  1  2                                 |             
      Degeneration                         |                                                          3               |             
      Hematopoietic Cell Proliferation     |                               2        2                       1         |             
      Inflammation, Focal, Granulomatous   | 2  1  1  1     2        1              1        1  1  1        1         |             
      Leukocytosis                         |                                                       2                  |             
      Necrosis                             |                      1        1        1                                1|             
      Pigmentation                         |             2                                                            |             
      Bile Duct, Hyperplasia               |       1  1  1  1  2        2     1     1                 1     1         |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Fat, Inflammation, Chronic           |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                      2     1                 2  1     1              3   |             
      Cytomegaly                           |       1                                                                  |             
      Hyperplasia                          |                                                                          |             
      Artery, Mineralization               |                                        2                                 |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                +                                                         |             
      Palate, Inflammation, Chronic        |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                 2                        |             
      Duct, Hyperplasia                    |                                  1           1                           |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                                          |             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                        3                                 |             
      Ulcer                                |                                                          2               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  11                                                               
NTP Experiment-Test: 05078-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 05/05/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:29:24  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 5| 7| 6| 5| 5| 7| 7| 7| 6| 6| 5| 5| 7| 6| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 2| 2| 3| 8| 9| 0| 8| 7| 5| 3| 3| 3| 8| 1| 9| 7| 3| 5| 3|             
                                           | 0| 0| 0| 0| 0| 0| 0| 3| 0| 8| 4| 7| 9| 4| 9| 0| 0| 0| 8| 2| 9| 3| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    15000 PP                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    M                                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                        +                                 |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                    +                     |             
      Inflammation                         |                                                    2                     |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                | 2  2  1  2  2  2     2  1  2  1        3     1  2  2  2  1  2  1  2  2   |             
      Artery, Mineralization               |                                        3                                 |             
      Atrium, Thrombosis                   |                            1     2                                       |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Fatty                  |    2     1  2  1           2     3                 1           1  2  2   |             
      Degeneration                         |                                        3                                 |             
      Hematopoietic Cell Proliferation     |    1  1                                         2           1  1         |             
      Hemorrhage                           |                                        2                                 |             
      Hyperplasia                          |                                  2  2           1                       2|             
      Hypertrophy                          |    3                                                                     |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | I  M  +  +  +  +  +  +  +  +  M  +  +  +  M  +  I  M  +  M  +  +  +  +  +|             
      Hyperplasia                          |                   2        4                                             |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M  +  +  +  +  M  +  M  M  M  +  +  +  +  +  +  +  M  M  M  M  +  +|             
      Hyperplasia                          |                                        4                                 |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                         X     X                                          |             
      Pars Distalis, Hemorrhage            |                                                          2               |             
      Pars Distalis, Hyperplasia           |             3        4           2        2                          2   |             
      Pars Distalis, Infiltration Cellular,|                                                                          |             
           Mixed Cell                      |                                                    1                     |             
      Pars Distalis, Pigmentation,         |                                                                          |             
          Hemosiderin                      |                                  2        2                              |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Mineralization                       |                                        1                                 |             
      C-Cell, Hyperplasia                  |    4  1  1  1  2  2     2        1  1  1  1  2  1  2  2                 2|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  I  +  +  M  M  +  +  +  +  +  M  +  +  M  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Suppurative            |          1     1                                                         |             
      Duct, Hyperplasia                    |             4                                                            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  12                                                               
NTP Experiment-Test: 05078-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 05/05/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:29:24  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 5| 7| 6| 5| 5| 7| 7| 7| 6| 6| 5| 5| 7| 6| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 2| 2| 3| 8| 9| 0| 8| 7| 5| 3| 3| 3| 8| 1| 9| 7| 3| 5| 3|             
                                           | 0| 0| 0| 0| 0| 0| 0| 3| 0| 8| 4| 7| 9| 4| 9| 0| 0| 0| 8| 2| 9| 3| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    15000 PP                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    M                                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |             3     2              2                 3                     |             
      Cyst                                 |                                                                      2  1|             
      Interstitium, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Endometrium, Hyperplasia, Cystic     |             4                                                            |             
      Endometrium, Hyperplasia             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Histiocyte    |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                        3                                 |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Depletion Cellular                   |                            4                                             |             
      Hyperplasia                          |          2                             2        2                 2      |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematocyst                           |                                                             2            |             
      Hematopoietic Cell Proliferation     |                               3        2  3                    3         |             
      Inflammation, Focal, Granulomatous   | 2  1                                                                     |             
      Pigmentation, Hemosiderin            |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  M  +  +  +  +  +  +  M  +  +  M  +  +  M  +  +  M  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2  2  1  1  2  1  2  1     2  1  2  2  2  1  1  2  2  1  2  2  1  2  2  2|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Acanthosis                           |                                                       4        2         |             
      Inflammation, Suppurative            |                                                       2        2         |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                                        3                                 |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Gliosis                              |                                                 2                        |             
      Hemorrhage, Focal                    |                                                          3  1            |             
      Inflammation                         |                                                                          |             
      Necrosis, Focal                      |                                                          2               |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  13                                                               
NTP Experiment-Test: 05078-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 05/05/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:29:24  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 5| 7| 6| 5| 5| 7| 7| 7| 6| 6| 5| 5| 7| 6| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 2| 2| 3| 8| 9| 0| 8| 7| 5| 3| 3| 3| 8| 1| 9| 7| 3| 5| 3|             
                                           | 0| 0| 0| 0| 0| 0| 0| 3| 0| 8| 4| 7| 9| 4| 9| 0| 0| 0| 8| 2| 9| 3| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    15000 PP                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    M                                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Inflammation, Suppurative            |    2     1        1                 1                             1      |             
      Epithelium, Hyperplasia              |                                     1                          2         |             
      Submucosa, Inflammation              |                                                                2         |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Edema                                |                                           2                              |             
      Hemorrhage                           |                                        2  3           1                  |             
      Infiltration Cellular, Histiocyte    |                            2           2  3                          1   |             
      Inflammation, Chronic, Diffuse       |                                        2                                 |             
      Inflammation, Chronic, Focal         |                            2                                             |             
      Mineralization                       |                                        2                                 |             
      Necrosis                             |                                           1                              |             
      Thrombosis                           |                                  1                                       |             
      Alveolar Epithelium, Hyperplasia     |                            1        1                          2     1   |             
      Bronchiole, Epithelium, Hyperplasia  |                                                                          |             
      Perivascular, Infiltration Cellular, |                                                                          |             
           Mononuclear Cell                | 1  1     1           2  1           2        1  2     2        2     1  1|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                              1                           |             
      Thrombosis                           |                      1           2        3              3               |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |    2                             1        1                          1   |             
      Respiratory Epithelium, Hyperplasia  |                      1     1     1     2     1                           |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                                        2                                 |             
      Submucosa, Inflammation              | 2  1  1        1     1  1     2  2  1  3     2  1  1  1        1  1  1   |             
      Vomeronasal Organ, Inflammation,     |                                                                          |             
           Suppurative                     |    1                                                                     |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Inflammation, Suppurative            | 1                                                                        |             
      Epithelium, Hyperplasia              |                                                                          |             
      Submucosa, Inflammation              |                                                                      2   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     | +  +                                                     +               |             
      Cataract                             |                                                          2               |             
      Hemorrhage                           |                                                          2               |             
      Inflammation, Chronic                |                                                                          |             
      Synechia                             | 4                                                                        |             
      Bilateral, Cataract                  | 4                                                                        |             
      Retina, Atrophy                      | 4  2                                                                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  14                                                               
NTP Experiment-Test: 05078-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 05/05/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:29:24  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 5| 7| 6| 5| 5| 7| 7| 7| 6| 6| 5| 5| 7| 6| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 2| 2| 3| 8| 9| 0| 8| 7| 5| 3| 3| 3| 8| 1| 9| 7| 3| 5| 3|             
                                           | 0| 0| 0| 0| 0| 0| 0| 3| 0| 8| 4| 7| 9| 4| 9| 0| 0| 0| 8| 2| 9| 3| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    15000 PP                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    M                                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |    +                                                                     |             
      Inflammation, Suppurative            |    2                                                                     |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                            +                                             |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydronephrosis                       |                                                                          |             
      Mineralization                       |                                        2                                 |             
      Nephropathy                          | 3  3  2  3     2  2  1  2  1  1  3  2  4     2  3  2  2  1  2  1  2  1  2|             
      Renal Tubule, Hyperplasia, Focal     | 2                                                                        |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Hemorrhage                           |                                                          2               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  15                                                               
NTP Experiment-Test: 05078-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 05/05/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:29:24  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 6| 5| 7| 7| 6| 7| 6| 6| 5| 6| 7| 7| 7| 5| 7| 4| 3| 6| 7| 7| 7| 5| 5|            |
                             DAY ON TEST   | 4| 3| 0| 7| 3| 3| 7| 3| 2| 7| 8| 4| 3| 3| 3| 3| 3| 9| 6| 2| 3| 1| 3| 4| 6|            |
                                           | 5| 0| 8| 3| 0| 0| 9| 0| 2| 2| 8| 3| 0| 0| 0| 5| 0| 0| 4| 9| 0| 4| 0| 6| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    15000 PP                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    M                                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Anus, Parasite Metazoan              |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|  48        |
      Parasite Metazoan                    |       X                       X           X           X                 X|      6     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Parasite Metazoan                    |                X  X  X     X                 X                           |      7     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  44        |
      Parasite Metazoan                    |                                                                          |      3     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  43        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                  1                                       |      1  1.0|
      Basophilic Focus                     |    1  1  1     1  1  1        1        1  1                 2  1         |     22  1.2|
      Congestion                           |                                                                          |      1  2.0|
      Degeneration, Fatty                  |                         3                                      2         |      6  2.0|
      Degeneration                         |                            2                                             |      2  2.5|
      Hematopoietic Cell Proliferation     |          2                                         2                     |      5  1.8|
      Inflammation, Focal, Granulomatous   | 2  1     1                    1     1           1           2  1  2  1   |     21  1.2|
      Leukocytosis                         |                                                                          |      1  2.0|
      Necrosis                             |                         1                    1           1              2|      8  1.1|
      Pigmentation                         |                                                                          |      1  2.0|
      Bile Duct, Hyperplasia               |                            1     2                                       |     12  1.3|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                    +        +            |   2        |
      Fat, Inflammation, Chronic           |                                                             2            |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |          1                                               3  1            |      9  1.7|
      Cytomegaly                           | 1                                                                        |      2  1.0|
      Hyperplasia                          |                                              3                           |      1  3.0|
      Artery, Mineralization               |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                                             +            |   2        |
      Palate, Inflammation, Chronic        |                                                             3            |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Duct, Hyperplasia                    |                   1              2           2              1            |      6  1.3|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  16                                                               
NTP Experiment-Test: 05078-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 05/05/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:29:24  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 6| 5| 7| 7| 6| 7| 6| 6| 5| 6| 7| 7| 7| 5| 7| 4| 3| 6| 7| 7| 7| 5| 5|            |
                             DAY ON TEST   | 4| 3| 0| 7| 3| 3| 7| 3| 2| 7| 8| 4| 3| 3| 3| 3| 3| 9| 6| 2| 3| 1| 3| 4| 6|            |
                                           | 5| 0| 8| 3| 0| 0| 9| 0| 2| 2| 8| 3| 0| 0| 0| 5| 0| 0| 4| 9| 0| 4| 0| 6| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    15000 PP                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    M                                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Ulcer                                |                                                    4                     |      1  4.0|
      Epithelium, Hyperplasia              |                         3                                                |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  49        |
      Mineralization                       |                                                                          |      1  3.0|
      Ulcer                                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
      Inflammation                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |    2  1  1  2  2  2  2     3  1  1  1  2  1     2  2  2  1  2  2  2  1   |     41  1.7|
      Artery, Mineralization               |                                                                          |      1  3.0|
      Atrium, Thrombosis                   |                                                                          |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Degeneration, Fatty                  |                   2        3           3  1        2        2  3  1      |     18  1.9|
      Degeneration                         |                                                                          |      1  3.0|
      Hematopoietic Cell Proliferation     |                                                                         2|      6  1.3|
      Hemorrhage                           |                                                                          |      1  2.0|
      Hyperplasia                          |                      1  2                       2           2     2      |      9  1.8|
      Hypertrophy                          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  I  +  +  +  +  +  +  M  +|  40        |
      Hyperplasia                          |                         2                                                |      3  2.7|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  M  +  +  +  +  +  M  M  M  +  +  +  I  M  +  M  +  +  M  M  +  +  +|  31        |
      Hyperplasia                          |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Cyst                  |                                              2     2                     |      4  2.0|
      Pars Distalis, Hemorrhage            |                                                                          |      1  2.0|
      Pars Distalis, Hyperplasia           | 2        3     3                    2     3           1                  |     11  2.5|
      Pars Distalis, Infiltration Cellular,|                                                                          |            |
           Mixed Cell                      |                                                                          |      1  1.0|
      Pars Distalis, Pigmentation,         |                                                                          |            |
          Hemosiderin                      |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Mineralization                       |                                                                          |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  17                                                               
NTP Experiment-Test: 05078-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 05/05/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:29:24  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 6| 5| 7| 7| 6| 7| 6| 6| 5| 6| 7| 7| 7| 5| 7| 4| 3| 6| 7| 7| 7| 5| 5|            |
                             DAY ON TEST   | 4| 3| 0| 7| 3| 3| 7| 3| 2| 7| 8| 4| 3| 3| 3| 3| 3| 9| 6| 2| 3| 1| 3| 4| 6|            |
                                           | 5| 0| 8| 3| 0| 0| 9| 0| 2| 2| 8| 3| 0| 0| 0| 5| 0| 0| 4| 9| 0| 4| 0| 6| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    15000 PP                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    M                                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      C-Cell, Hyperplasia                  | 2  1  3  1  1  2  2     2  1  1     1  1        1           1     1      |     31  1.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  43        |
      Hyperplasia                          |                                                                      4   |      1  4.0|
      Inflammation, Suppurative            |                                                                      3   |      3  1.7|
      Duct, Hyperplasia                    |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                                          |      4  2.5|
      Cyst                                 |                1     2           1                                       |      5  1.4|
      Interstitium, Hyperplasia            | 4                                                                        |      1  4.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Endometrium, Hyperplasia, Cystic     |                                                                          |      1  4.0|
      Endometrium, Hyperplasia             |                      2                                                   |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infiltration Cellular, Histiocyte    |                                                                4         |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|  47        |
      Congestion                           |                                                                          |      1  3.0|
      Hyperplasia                          |             2                                                            |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  M  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  M  +  +  +  M|  43        |
      Depletion Cellular                   |                                                                          |      1  4.0|
      Hyperplasia                          |          2  2           3                       2                        |      8  2.1|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hematocyst                           |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |          2                                         2           2         |      7  2.4|
      Inflammation, Focal, Granulomatous   |                                                                          |      2  1.5|
      Pigmentation, Hemosiderin            |                                                       1           2      |      2  1.5|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  M  M  M  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|  39        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          | 2  1  1  1  2  1  2  1  2  2  2  2  2  2  2  1  2  2     4  2     2  2  2|     47  1.7|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  18                                                               
NTP Experiment-Test: 05078-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 05/05/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:29:24  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 6| 5| 7| 7| 6| 7| 6| 6| 5| 6| 7| 7| 7| 5| 7| 4| 3| 6| 7| 7| 7| 5| 5|            |
                             DAY ON TEST   | 4| 3| 0| 7| 3| 3| 7| 3| 2| 7| 8| 4| 3| 3| 3| 3| 3| 9| 6| 2| 3| 1| 3| 4| 6|            |
                                           | 5| 0| 8| 3| 0| 0| 9| 0| 2| 2| 8| 3| 0| 0| 0| 5| 0| 0| 4| 9| 0| 4| 0| 6| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    15000 PP                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    M                                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Acanthosis                           |                                                                          |      2  3.0|
      Inflammation, Suppurative            |                         2                                                |      3  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrous Osteodystrophy               |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |       +                                                                  |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Gliosis                              |                                                                          |      1  2.0|
      Hemorrhage, Focal                    |                                                                          |      2  2.0|
      Inflammation                         | 1                                                                        |      1  1.0|
      Necrosis, Focal                      |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Suppurative            |    1  1                                                                  |      7  1.1|
      Epithelium, Hyperplasia              |                                                                          |      2  1.5|
      Submucosa, Inflammation              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                                       4              3   |      2  3.5|
      Edema                                |                                                       2                  |      2  2.0|
      Hemorrhage                           |                            1                                             |      4  1.8|
      Infiltration Cellular, Histiocyte    | 1        1  2           1  2     1  1              1                    1|     13  1.5|
      Inflammation, Chronic, Diffuse       |                                                                          |      1  2.0|
      Inflammation, Chronic, Focal         |             2                       1                                   2|      4  1.8|
      Mineralization                       |                                                                          |      1  2.0|
      Necrosis                             |                                                                          |      1  1.0|
      Thrombosis                           |                                                                          |      1  1.0|
      Alveolar Epithelium, Hyperplasia     |    4  2                             1           2                        |      8  1.8|
      Bronchiole, Epithelium, Hyperplasia  | 2                                                                        |      1  2.0|
      Perivascular, Infiltration Cellular, |                                                                          |            |
           Mononuclear Cell                |    1              2           1     1  1  2                 1            |     19  1.4|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |    2  1                                   2                    1  1      |      6  1.3|
      Thrombosis                           |                            1                                             |      5  2.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |                   3     3                 1              2     2     2   |     10  1.8|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  19                                                               
NTP Experiment-Test: 05078-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 05/05/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:29:24  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 6| 5| 7| 7| 6| 7| 6| 6| 5| 6| 7| 7| 7| 5| 7| 4| 3| 6| 7| 7| 7| 5| 5|            |
                             DAY ON TEST   | 4| 3| 0| 7| 3| 3| 7| 3| 2| 7| 8| 4| 3| 3| 3| 3| 3| 9| 6| 2| 3| 1| 3| 4| 6|            |
                                           | 5| 0| 8| 3| 0| 0| 9| 0| 2| 2| 8| 3| 0| 0| 0| 5| 0| 0| 4| 9| 0| 4| 0| 6| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    15000 PP                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    M                                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Respiratory Epithelium, Hyperplasia  |    2                             1        1                    2     1   |     10  1.3|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        |                                                                          |      1  2.0|
      Submucosa, Inflammation              | 1  2  1     1  1  1     2  1        2  2  2     1           2  2  1  1  1|     34  1.4|
      Vomeronasal Organ, Inflammation,     |                                                                          |            |
           Suppurative                     |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Suppurative            |                                                                          |      1  1.0|
      Epithelium, Hyperplasia              |             2                                                            |      1  2.0|
      Submucosa, Inflammation              |             1                                                            |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |          +              +                                                |   2        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                 +                    +   |   5        |
      Cataract                             |                                                 4                        |      2  3.0|
      Hemorrhage                           |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                 4                        |      1  4.0|
      Synechia                             |                                                                          |      1  4.0|
      Bilateral, Cataract                  |                                                                          |      1  4.0|
      Retina, Atrophy                      |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
      Inflammation, Suppurative            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                         +                                                |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hydronephrosis                       |       1                                                                  |      1  1.0|
      Mineralization                       |                                                                          |      1  2.0|
      Nephropathy                          |    2        3  2  2  1  2  1  1  2     2  2  1  2        1  3  2  2  2  1|     42  1.9|
      Renal Tubule, Hyperplasia, Focal     |                3                                                         |      2  2.5|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hemorrhage                           |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  20                                                               
NTP Experiment-Test: 05078-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 05/05/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:29:24  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 6| 6| 6| 7| 6| 5| 6| 4| 6| 7| 6| 6| 6| 5| 7| 6| 7| 7| 7| 6| 5| 7|             
                             DAY ON TEST   | 8| 9| 3| 9| 8| 6| 3| 9| 7| 7| 8| 5| 3| 4| 7| 5| 7| 3| 9| 3| 3| 3| 6| 2| 2|             
                                           | 2| 6| 0| 6| 2| 8| 0| 8| 0| 1| 5| 8| 0| 5| 5| 4| 0| 0| 9| 0| 0| 0| 5| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                               X              X              X           X|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |       X  X  X              X  X                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Parasite Metazoan                    |                               X                    X        X            |             
      Serosa, Inflammation, Chronic        | 4                                                                        |             
      Serosa, Thrombosis                   | 4                                                                        |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  M  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | 1  1                 1              1              1           1         |             
      Clear Cell Focus                     |                                                             2            |             
      Degeneration, Cystic                 |                                                                         1|             
      Degeneration, Fatty                  |                                           1  2                    3  2   |             
      Degeneration                         |                                  4              1                        |             
      Fibrosis                             |    2                                                                     |             
      Hemorrhage                           |                                                                          |             
      Hepatodiaphragmatic Nodule           |                            X                          X                  |             
      Inflammation, Focal, Granulomatous   |                                                       1                  |             
      Necrosis                             | 2  2        1  1           1                                      1  2   |             
      Bile Duct, Hyperplasia               | 2  3  2  2  3  2     2  2  2  2  3  2  1  2  2  2  1  2  2  1  1        2|             
      Hepatocyte, Hyperplasia              |       3     3                                                            |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                   +      |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |    1  1  3     1  1     1        1  1        2  2  2           1  4      |             
      Cytomegaly                           | 1     1                                                                  |             
      Pigmentation, Hemosiderin            |                                                                   3      |             
      Artery, Intima, Hyperplasia          |                                                                          |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                                          |             
      Palate, Inflammation, Chronic        |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Duct, Hyperplasia                    |    1        1        1                                                   |             
      Duct, Inflammation, Suppurative      |                      1                                         1         |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  I  +  +  +  +|             
      Inflammation, Chronic                |                                                                4         |             
      Inflammation, Suppurative            |                                              3                    1  2   |             
      Ulcer                                |                                              3                    1  3   |             
      Epithelium, Hyperplasia              |                                              3                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  21                                                               
NTP Experiment-Test: 05078-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 05/05/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:29:24  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 6| 6| 6| 7| 6| 5| 6| 4| 6| 7| 6| 6| 6| 5| 7| 6| 7| 7| 7| 6| 5| 7|             
                             DAY ON TEST   | 8| 9| 3| 9| 8| 6| 3| 9| 7| 7| 8| 5| 3| 4| 7| 5| 7| 3| 9| 3| 3| 3| 6| 2| 2|             
                                           | 2| 6| 0| 6| 2| 8| 0| 8| 0| 1| 5| 8| 0| 5| 5| 4| 0| 0| 9| 0| 0| 0| 5| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                         +|             
      Gingiva, Hyperplasia,                |                                                                          |             
          Pseudoepitheliomatous            |                                                                         4|             
      Peridontal Tissue, Inflammation,     |                                                                          |             
           Chronic, Suppurative            |                                                                         3|             
      Pulp, Inflammation, Suppurative      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                | 3     2        2  2        2  2  2  1  3  2  2  2  1  2  2  2  2  2  2  2|             
      Atrium, Thrombosis                   |                                  2                                3      |             
      Perivascular, Inflammation           |                                                             2            |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Fatty                  | 2  1     1  2        1           1        1  2  1     2  2  1  2         |             
      Hematopoietic Cell Proliferation     |                                     2                                    |             
      Hyperplasia                          | 2        1     3           2     1                          2            |             
      Hypertrophy                          |                            2                                             |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  M  +  +  +  M  +  +  M  +  +  M  M  M  +  +  +  +  +  +  +  M  +|             
      Hyperplasia                          | 4  3                       2     1              4  4  1  3        2      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Hyperplasia                          |                                                       1                  |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  M  M  M  +  +  M  M  +  +  M  M  M  M  +  +  +  +  +  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hemorrhage            |                      4                                                   |             
      Pars Distalis, Hyperplasia           |                4        1                       3                 1      |             
      Pars Distalis, Necrosis              |                      3                                                   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |    2     1  2              4              2        3                    4|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                       +                  |             
      Inflammation, Chronic                |                                                       2                  |             
      Necrosis                             |                                                       3                  |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  M  +  M  M  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Mineralization                       |    3                                                                     |             
      Vacuolization Cytoplasmic            |    2     3  2  1                       2  3  3                          4|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  22                                                               
NTP Experiment-Test: 05078-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 05/05/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:29:24  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 6| 6| 6| 7| 6| 5| 6| 4| 6| 7| 6| 6| 6| 5| 7| 6| 7| 7| 7| 6| 5| 7|             
                             DAY ON TEST   | 8| 9| 3| 9| 8| 6| 3| 9| 7| 7| 8| 5| 3| 4| 7| 5| 7| 3| 9| 3| 3| 3| 6| 2| 2|             
                                           | 2| 6| 0| 6| 2| 8| 0| 8| 0| 1| 5| 8| 0| 5| 5| 4| 0| 0| 9| 0| 0| 0| 5| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  I  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                     X                                    |             
      Inflammation, Suppurative            | 2        1           1                    2        2        1            |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |             2     2                       4                              |             
      Inflammation, Chronic                |                                           3                              |             
      Inflammation, Suppurative            | 3  2              1  1     1              4  2     2     2  1            |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |          +     +                 +                                       |             
      Inflammation, Suppurative            |          2     2                 1                                       |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |    2  3     4  4  4        3     4  3              3  4  1  3     4     3|             
      Interstitial Cell, Hyperplasia       | 1        2                    1                 1        1               |             
      Perivascular, Inflammation           |                      2                                1        2         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myelofibrosis                        |    1                                                                     |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesenteric, Hematopoietic Cell       |                                                                          |             
          Proliferation                    |                                                 2                        |             
      Pancreatic, Hyperplasia              |                            2                                             |             
      Renal, Hematopoietic Cell            |                                                                          |             
          Proliferation                    |                                                 2                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2                                                                        |             
      Pigmentation, Hemosiderin            |                                                                   2      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  I  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                     2                                    |             
      Hyperplasia                          | 2                    2     2     2                 2  2     3  3     2  2|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |    4                                      2                              |             
      Hematopoietic Cell Proliferation     |                                                                   2  3   |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +  M  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  M  +  +  +  +  +|             
      Epithelial Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  +  M  M  M  +  M  M  M  +  +  M  M  M  M  M  M  M  M  M  M  M  M  +|             
      Hyperplasia                          |       1           2                                                     2|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Pigmentation, Hemosiderin            |                                                                          |             
      Prepuce, Abscess                     |                                                                          |             
      Prepuce, Epithelium, Hyperplasia     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  23                                                               
NTP Experiment-Test: 05078-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 05/05/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:29:24  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 6| 6| 6| 7| 6| 5| 6| 4| 6| 7| 6| 6| 6| 5| 7| 6| 7| 7| 7| 6| 5| 7|             
                             DAY ON TEST   | 8| 9| 3| 9| 8| 6| 3| 9| 7| 7| 8| 5| 3| 4| 7| 5| 7| 3| 9| 3| 3| 3| 6| 2| 2|             
                                           | 2| 6| 0| 6| 2| 8| 0| 8| 0| 1| 5| 8| 0| 5| 5| 4| 0| 0| 9| 0| 0| 0| 5| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage, Focal                    |                2                       2     3                           |             
      Hydrocephalus                        |                                                                          |             
      Necrosis, Focal                      |                2                             2                           |             
      Meninges, Hemorrhage                 |                      2                                                   |             
      Meninges, Inflammation, Suppurative  |                      2                                                   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |             1           1              1     1  1     2        1        1|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                               3                                          |             
      Edema                                |                                        3                                 |             
      Hemorrhage                           |                                        3     1  1                        |             
      Infiltration Cellular, Histiocyte    |          2                       1                    1                  |             
      Infiltration Cellular, Mixed Cell    |                                                                   3      |             
      Inflammation, Chronic, Focal         | 2  1                                                     1               |             
      Metaplasia, Osseous                  |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |          3                       2                    1     4            |             
      Perivascular, Infiltration Cellular, |                                                                          |             
           Mononuclear Cell                |                      1        1                             1  2         |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                        1                                 |             
      Inflammation, Suppurative            | 1                                2        1     2     1     1  2     2  1|             
      Thrombosis                           |          1  2  2                 3        2                       4     1|             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |             2        2     2     2  1     2  2        2           2      |             
      Respiratory Epithelium, Hyperplasia  |                      2           2     1        3           3  2     3   |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                                                 1                        |             
      Submucosa, Inflammation              | 1                 1  2        1  2  2           3  2  2  2  3  2     3   |             
      Vomeronasal Organ, Inflammation,     |                                                                          |             
           Suppurative                     |                                                                      1   |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                              1                           |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |    M                       +                                             |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                         +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  24                                                               
NTP Experiment-Test: 05078-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 05/05/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:29:24  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 6| 6| 6| 7| 6| 5| 6| 4| 6| 7| 6| 6| 6| 5| 7| 6| 7| 7| 7| 6| 5| 7|             
                             DAY ON TEST   | 8| 9| 3| 9| 8| 6| 3| 9| 7| 7| 8| 5| 3| 4| 7| 5| 7| 3| 9| 3| 3| 3| 6| 2| 2|             
                                           | 2| 6| 0| 6| 2| 8| 0| 8| 0| 1| 5| 8| 0| 5| 5| 4| 0| 0| 9| 0| 0| 0| 5| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Degeneration                         |                                                                         4|             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fatty Change                         |                                                                          |             
      Hematopoietic Cell Proliferation     |                                     1                                2   |             
      Inflammation, Suppurative            | 1                                                  1        1            |             
      Nephropathy                          | 3  3  3  3  3  2  2  4  1  4  2  1  3  2  4  3  1  3  2  2  3  4  1  2  2|             
      Pelvis, Inflammation, Suppurative    |                                           2                              |             
      Pelvis, Necrosis                     |                                           2                              |             
      Pelvis, Epithelium, Hyperplasia      |                                                                          |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                           +                              |             
      Inflammation, Suppurative            |                                           2                              |             
      Epithelium, Hyperplasia              |                                           3                              |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                           4                              |             
      Transitional Epithelium, Hyperplasia |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  25                                                               
NTP Experiment-Test: 05078-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 05/05/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:29:24  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 6| 7| 6| 7| 7| 6| 5| 7| 6| 7| 5| 6| 7| 5| 6| 5| 5| 5| 7| 5| 6|            |
                             DAY ON TEST   | 3| 2| 3| 1| 7| 3| 1| 3| 3| 8| 0| 3| 4| 3| 1| 5| 3| 4| 9| 6| 4| 8| 3| 1| 4|            |
                                           | 0| 6| 0| 7| 2| 0| 1| 0| 0| 9| 0| 0| 6| 0| 2| 4| 0| 2| 2| 7| 5| 7| 0| 7| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  49        |
      Parasite Metazoan                    |    X                                   X           X        X            |      8     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                                                                          |      5     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Parasite Metazoan                    |       X                                                                  |      4     |
      Serosa, Inflammation, Chronic        |                                                                          |      1  4.0|
      Serosa, Thrombosis                   |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |       2  3  1           2  1     1  1  1     1  1              1        1|     18  1.2|
      Clear Cell Focus                     |                                  1              2                        |      3  1.7|
      Degeneration, Cystic                 |                         1  1                                             |      3  1.0|
      Degeneration, Fatty                  | 1     1                                      2              1        2   |      9  1.7|
      Degeneration                         |                                                                          |      2  2.5|
      Fibrosis                             |                                                                          |      1  2.0|
      Hemorrhage                           |                                                                      2   |      1  2.0|
      Hepatodiaphragmatic Nodule           |                                                                          |      2     |
      Inflammation, Focal, Granulomatous   |          1  1                       2                       2  1         |      6  1.3|
      Necrosis                             |                                                                          |      7  1.4|
      Bile Duct, Hyperplasia               | 1     2  1  1  1  1  2  1  1  1  1  1  1     1  1  1  1  1     1  1  1  1|     44  1.5|
      Hepatocyte, Hyperplasia              |                            1                                             |      3  2.3|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              | 1     1              2  2        2     1        2  1  2  1        1      |     24  1.5|
      Cytomegaly                           |                                                                          |      2  1.0|
      Pigmentation, Hemosiderin            |                                                                          |      1  3.0|
      Artery, Intima, Hyperplasia          |                         2                                                |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                           +           +                  |   2        |
      Palate, Inflammation, Chronic        |                                           2           2                  |      2  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Duct, Hyperplasia                    | 1        1                             1           1  1  1        2      |     10  1.1|
      Duct, Inflammation, Suppurative      |                                                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  26                                                               
NTP Experiment-Test: 05078-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 05/05/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:29:24  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 6| 7| 6| 7| 7| 6| 5| 7| 6| 7| 5| 6| 7| 5| 6| 5| 5| 5| 7| 5| 6|            |
                             DAY ON TEST   | 3| 2| 3| 1| 7| 3| 1| 3| 3| 8| 0| 3| 4| 3| 1| 5| 3| 4| 9| 6| 4| 8| 3| 1| 4|            |
                                           | 0| 6| 0| 7| 2| 0| 1| 0| 0| 9| 0| 0| 6| 0| 2| 4| 0| 2| 2| 7| 5| 7| 0| 7| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Inflammation, Chronic                |                                                                      3   |      2  3.5|
      Inflammation, Suppurative            |                                                                          |      3  2.0|
      Ulcer                                |                                                                      3   |      4  2.5|
      Epithelium, Hyperplasia              |                                                                      2   |      2  2.5|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Tooth                                   | +                                                                       +|   3        |
      Gingiva, Hyperplasia,                |                                                                          |            |
          Pseudoepitheliomatous            |                                                                          |      1  4.0|
      Peridontal Tissue, Inflammation,     |                                                                          |            |
           Chronic, Suppurative            | 2                                                                        |      2  2.5|
      Pulp, Inflammation, Suppurative      |                                                                         2|      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                | 2  2  1  2  2  2  2  2  3  1     1  1  2     2  2  1  1  3  1  2  4  2  2|     43  1.9|
      Atrium, Thrombosis                   |                                                                          |      2  2.5|
      Perivascular, Inflammation           |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Degeneration, Fatty                  | 1        2           1  1           2                    2  1  2  2  2   |     23  1.5|
      Hematopoietic Cell Proliferation     |       1                                                                  |      2  1.5|
      Hyperplasia                          |                      3              4     2  3                 1  3  3   |     13  2.3|
      Hypertrophy                          |                                        3                                 |      2  2.5|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  I  +  +  +  M  I  +  +  M  +  M  +  M  M  +  +  +  +  +  +  +  +  +  +|  36        |
      Hyperplasia                          | 3        1                                                               |     11  2.5|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  48        |
      Hyperplasia                          |                               1                    1                     |      3  1.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  M  M  +  +  M  +  +  +  M  +  +  +  +  +  M  +  +  +  M  M  +  +  +|  31        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Pars Distalis, Cyst                  |             X                                                            |      1     |
      Pars Distalis, Hemorrhage            |                                                                          |      1  4.0|
      Pars Distalis, Hyperplasia           |    1        1  2        3                       2              2         |     10  2.0|
      Pars Distalis, Necrosis              |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      C-Cell, Hyperplasia                  |          3  3        2  1  1        1     1     1        1  2     1  1   |     19  1.9|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  27                                                               
NTP Experiment-Test: 05078-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 05/05/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:29:24  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 6| 7| 6| 7| 7| 6| 5| 7| 6| 7| 5| 6| 7| 5| 6| 5| 5| 5| 7| 5| 6|            |
                             DAY ON TEST   | 3| 2| 3| 1| 7| 3| 1| 3| 3| 8| 0| 3| 4| 3| 1| 5| 3| 4| 9| 6| 4| 8| 3| 1| 4|            |
                                           | 0| 6| 0| 7| 2| 0| 1| 0| 0| 9| 0| 0| 6| 0| 2| 4| 0| 2| 2| 7| 5| 7| 0| 7| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 GENERAL BODY SYSTEM - cont                |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Necrosis                             |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  I  +  +  M  +  +  M  +  M  M  +  +  +  +  M  +  M  +  M  +  +  +  +|  37        |
      Inflammation, Chronic                |                   2                                                      |      1  2.0|
      Mineralization                       |                                                                          |      1  3.0|
      Vacuolization Cytoplasmic            |             1              2        3        3                 2        3|     14  2.4|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  47        |
      Cyst                                 |                                                                          |      1     |
      Inflammation, Suppurative            |    1        1                    4                                      2|     10  1.7|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                  1                                       |      4  2.3|
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Inflammation, Suppurative            |                            4     2  1  2                          2     2|     16  2.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |          +     +  +  +                                                   |   7        |
      Inflammation, Suppurative            |          2     2  2  2                                                   |      7  1.9|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |       4  3  2     4     3  2     3     2        3     2        2  3     2|     27  3.0|
      Interstitial Cell, Hyperplasia       | 1  1           4     1                    1        1     1               |     12  1.3|
      Perivascular, Inflammation           |                                                                          |      3  1.7|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Myelofibrosis                        |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Mesenteric, Hematopoietic Cell       |                                                                          |            |
          Proliferation                    |                                                                          |      1  2.0|
      Pancreatic, Hyperplasia              |                                                                          |      1  2.0|
      Renal, Hematopoietic Cell            |                                                                          |            |
          Proliferation                    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +  M  +  +  +  +  M  +  +  M  +  M  +  +  +  +  M  +  +  +  +|  42        |
      Hyperplasia                          |                            1                                             |      2  1.5|
      Pigmentation, Hemosiderin            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  45        |
      Angiectasis                          |                                                                          |      1  2.0|
      Hyperplasia                          |       2  2              2  2     2     2     2  2        1               |     19  2.1|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  28                                                               
NTP Experiment-Test: 05078-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 05/05/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:29:24  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 6| 7| 6| 7| 7| 6| 5| 7| 6| 7| 5| 6| 7| 5| 6| 5| 5| 5| 7| 5| 6|            |
                             DAY ON TEST   | 3| 2| 3| 1| 7| 3| 1| 3| 3| 8| 0| 3| 4| 3| 1| 5| 3| 4| 9| 6| 4| 8| 3| 1| 4|            |
                                           | 0| 6| 0| 7| 2| 0| 1| 0| 0| 9| 0| 0| 6| 0| 2| 4| 0| 2| 2| 7| 5| 7| 0| 7| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             |       2                                                                  |      3  2.7|
      Hematopoietic Cell Proliferation     |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  M  +  +  +  M  +  +  +  +  +  M  +  +  M  M  +  +  +  +  +  M  +  +|  39        |
      Epithelial Cell, Hyperplasia         |                4                                                         |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  +  M  M  M  M  M  M  M  M  M  +  M  M  M  +  +  M  M  M  M  +  +  +  +|  13        |
      Hyperplasia                          |                                  1           2                    1  1  2|      8  1.5|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Acanthosis                           |                               2                                          |      1  2.0|
      Inflammation, Chronic                |                               3                                          |      1  3.0|
      Pigmentation, Hemosiderin            |                               1                                          |      1  1.0|
      Prepuce, Abscess                     | 3                                                                        |      1  3.0|
      Prepuce, Epithelium, Hyperplasia     |       2                                                                  |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage, Focal                    |                                                                          |      3  2.3|
      Hydrocephalus                        |                                                          3               |      1  3.0|
      Necrosis, Focal                      |                                                                          |      2  2.0|
      Meninges, Hemorrhage                 |                                                                          |      1  2.0|
      Meninges, Inflammation, Suppurative  |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Suppurative            |             1           1     1        1                       1        1|     14  1.1|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                                                          |      1  3.0|
      Edema                                |                                                                          |      1  3.0|
      Hemorrhage                           |    1                                                                     |      4  1.5|
      Infiltration Cellular, Histiocyte    |                1     2                                                   |      5  1.4|
      Infiltration Cellular, Mixed Cell    |                                                                          |      1  3.0|
      Inflammation, Chronic, Focal         |                      3                                                   |      4  1.8|
      Metaplasia, Osseous                  |                                  1                                       |      1  1.0|
      Alveolar Epithelium, Hyperplasia     |                1     2                                                   |      6  2.2|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  29                                                               
NTP Experiment-Test: 05078-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 05/05/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:29:24  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 6| 7| 6| 7| 7| 6| 5| 7| 6| 7| 5| 6| 7| 5| 6| 5| 5| 5| 7| 5| 6|            |
                             DAY ON TEST   | 3| 2| 3| 1| 7| 3| 1| 3| 3| 8| 0| 3| 4| 3| 1| 5| 3| 4| 9| 6| 4| 8| 3| 1| 4|            |
                                           | 0| 6| 0| 7| 2| 0| 1| 0| 0| 9| 0| 0| 6| 0| 2| 4| 0| 2| 2| 7| 5| 7| 0| 7| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Perivascular, Infiltration Cellular, |                                                                          |            |
           Mononuclear Cell                |    2                    1           1                 1  1               |      9  1.2|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |                                                                          |      1  1.0|
      Inflammation, Suppurative            |                               1           2                    4         |     12  1.7|
      Thrombosis                           |                   2                                                      |      8  2.1|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |             1                       3     3                              |     12  2.0|
      Respiratory Epithelium, Hyperplasia  |                   1                                            2         |      9  2.1|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        |                                                                          |      1  1.0|
      Submucosa, Inflammation              |          1  1  2        1  1           2        1        2        1      |     22  1.7|
      Vomeronasal Organ, Inflammation,     |                                                                          |            |
           Suppurative                     |                                                                         2|      2  1.5|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |                                                                1         |      2  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
      Degeneration                         |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                           +                              |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fatty Change                         |                                                       4                  |      1  4.0|
      Hematopoietic Cell Proliferation     |                                                                          |      2  1.5|
      Inflammation, Suppurative            |                                                 1                        |      4  1.0|
      Nephropathy                          | 3  1  3  3  3  2  2  3  3  4  2  4  3  3  1  3  3     2  1  2  3  4  3  3|     49  2.6|
      Pelvis, Inflammation, Suppurative    |                            2                                             |      2  2.0|
      Pelvis, Necrosis                     |                                                                          |      1  2.0|
      Pelvis, Epithelium, Hyperplasia      |                            3                                             |      1  3.0|
                                            __________________________________________________________________________|____________|
   Urethra                                 |                                                                          |   1        |
      Inflammation, Suppurative            |                                                                          |      1  2.0|
      Epithelium, Hyperplasia              |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |                            2                                             |      2  3.0|
      Transitional Epithelium, Hyperplasia |                            2                                             |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  30                                                               
NTP Experiment-Test: 05078-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 05/05/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:29:24  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 6| 5| 7| 7| 7| 7| 6| 6| 7| 7| 6| 5| 7| 6| 5| 6| 6| 5| 7| 6| 7| 5| 7|             
                             DAY ON TEST   | 2| 7| 7| 5| 2| 1| 2| 0| 2| 6| 2| 2| 8| 8| 0| 4| 8| 2| 1| 4| 2| 3| 1| 1| 0|             
                                           | 9| 9| 1| 2| 9| 6| 9| 9| 6| 4| 9| 9| 9| 1| 1| 6| 7| 1| 1| 9| 7| 3| 3| 9| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    15000 PP                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    M                                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +     +  A|             
      Parasite Metazoan                    |    X                                         X                           |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +     +  A|             
      Parasite Metazoan                    |             X                          X                                 |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  A  A  +     +  +|             
      Parasite Metazoan                    |    X                                                           X         |             
      Serosa, Inflammation, Chronic        |       1                                                                  |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  A  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  M  A  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  A|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |             3                                                            |             
      Basophilic Focus                     | 1                 1              1                                1      |             
      Clear Cell Focus                     | 1                                                                        |             
      Congestion                           |    3                                                                 3   |             
      Degeneration, Cystic                 | 1                    1     3                 2              2            |             
      Degeneration, Fatty                  |                         1     1                    3                     |             
      Degeneration                         |                            2                                             |             
      Hematopoietic Cell Proliferation     |          2                                                     1         |             
      Hepatodiaphragmatic Nodule           |                      X                                                   |             
      Inflammation, Focal, Granulomatous   |                                                                   2      |             
      Necrosis                             |                                                          2               |             
      Pigmentation                         |                                                                          |             
      Bile Duct, Hyperplasia               |                2  2  1  1  3  1  2  1  2  2  2  2  2     1  1  2        2|             
      Hepatocyte, Hyperplasia              | 1              3                                                  2      |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Atrophy                              |       1        2  1  2           1        1  1  2                        |             
      Cytomegaly                           |                      1                                                   |             
      Inflammation                         |       1                                                                  |             
      Pigmentation, Hemosiderin            |                                                                          |             
      Perivascular, Inflammation           |                                              3                           |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                           +                              |             
      Inflammation, Suppurative            |                                           2                              |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Duct, Hyperplasia                    | 1                 1  1  1     1     1        1        1                  |             
      Duct, Inflammation, Suppurative      |                   1                                                      |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                                                          |             
      Inflammation, Suppurative            |       2                                                                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  31                                                               
NTP Experiment-Test: 05078-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 05/05/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:29:24  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 6| 5| 7| 7| 7| 7| 6| 6| 7| 7| 6| 5| 7| 6| 5| 6| 6| 5| 7| 6| 7| 5| 7|             
                             DAY ON TEST   | 2| 7| 7| 5| 2| 1| 2| 0| 2| 6| 2| 2| 8| 8| 0| 4| 8| 2| 1| 4| 2| 3| 1| 1| 0|             
                                           | 9| 9| 1| 2| 9| 6| 9| 9| 6| 4| 9| 9| 9| 1| 1| 6| 7| 1| 1| 9| 7| 3| 3| 9| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    15000 PP                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    M                                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Ulcer                                |       3                                                                  |             
      Epithelium, Hyperplasia              |       3                                                                  |             
      Serosa, Inflammation, Chronic        |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                            1                       1     2               |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Mineralization                       |                                                                   3      |             
      Epithelium, Hyperplasia              |                                                                          |             
      Serosa, Inflammation, Chronic        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                | 2  1  2  2  2  2  3  1  2  1  2  2  2  2  1  3     2  1  2  2  2  3  2  2|             
      Artery, Mineralization               |                                                                   2      |             
      Atrium, Thrombosis                   |                                                    2                     |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Fatty                  | 1  1  2     2     1  1     2  2     2  1     1  1  1        2     2     1|             
      Hematopoietic Cell Proliferation     |          1                                                               |             
      Hyperplasia                          |                4              3                             2            |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |          1                                                               |             
      Hyperplasia                          | 4     1     1     2  1  1     2     4        3        2     3            |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Hyperplasia                          |                3                 1     1                                 |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  M  +  +  +  +  +|             
      Hyperplasia                          |                                  2                                3      |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |             X                                                            |             
      Pars Distalis, Hemorrhage            |                                                                          |             
      Pars Distalis, Hyperplasia           |                      3                                1  2               |             
      Pars Distalis, Inflammation,         |                                                                          |             
          Suppurative                      |                                                                          |             
      Pars Distalis, Pigmentation,         |                                                                          |             
          Hemosiderin                      |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  A  +  +  +  +|             
      C-Cell, Hyperplasia                  |          1  1  1        3        1  2  1  1  1                 1         |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |       +                                                                  |             
      Inflammation, Chronic                |                                                                          |             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  32                                                               
NTP Experiment-Test: 05078-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 05/05/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:29:24  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 6| 5| 7| 7| 7| 7| 6| 6| 7| 7| 6| 5| 7| 6| 5| 6| 6| 5| 7| 6| 7| 5| 7|             
                             DAY ON TEST   | 2| 7| 7| 5| 2| 1| 2| 0| 2| 6| 2| 2| 8| 8| 0| 4| 8| 2| 1| 4| 2| 3| 1| 1| 0|             
                                           | 9| 9| 1| 2| 9| 6| 9| 9| 6| 4| 9| 9| 9| 1| 1| 6| 7| 1| 1| 9| 7| 3| 3| 9| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    15000 PP                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    M                                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM - cont                |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  M  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Granuloma Sperm                      |                                                                          |             
      Vacuolization Cytoplasmic            | 2  1              2  1           1  2     2  2        2        2         |             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                   3      |             
      Inflammation, Suppurative            |                            2              1                              |             
      Duct, Hyperplasia                    |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2                 1           2     2     1                 2            |             
      Inflammation, Suppurative            |                1     1              2     1              3        2     2|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |    +           +                                +     +                  |             
      Inflammation, Suppurative            |    1           1                                1     2                  |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 3     4  2  1  2        4  2  2  2        2  2  3     2              3  3|             
      Interstitial Cell, Hyperplasia       |       3                             1           2        2              1|             
      Perivascular, Inflammation           | 3           2                 2     3        2                    2      |             
      Tunic, Hyperplasia                   |                                  2                                       |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Hyperplasia                          |          2                                                               |             
      Myelofibrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesenteric, Inflammation,            |                                                                          |             
          Granulomatous                    |    1                                                                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Hyperplasia                          |          2                                                               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  M  +  +  +  +  +  +  +  I  +|             
      Angiectasis                          |                                                                          |             
      Hyperplasia                          | 3                 2           2     2  2  3                             2|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                   1        2     2     2              1                 2|             
      Hematocyst                           |                                                                         3|             
      Hematopoietic Cell Proliferation     |          3                                                               |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  M|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  +  M  M  M  M  M  M  M  +  M  M  +  +  M  M  +  +  M  M  +  +  M  M|             
      Galactocele                          |       1                       1                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  33                                                               
NTP Experiment-Test: 05078-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 05/05/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:29:24  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 6| 5| 7| 7| 7| 7| 6| 6| 7| 7| 6| 5| 7| 6| 5| 6| 6| 5| 7| 6| 7| 5| 7|             
                             DAY ON TEST   | 2| 7| 7| 5| 2| 1| 2| 0| 2| 6| 2| 2| 8| 8| 0| 4| 8| 2| 1| 4| 2| 3| 1| 1| 0|             
                                           | 9| 9| 1| 2| 9| 6| 9| 9| 6| 4| 9| 9| 9| 1| 1| 6| 7| 1| 1| 9| 7| 3| 3| 9| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    15000 PP                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    M                                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hyperplasia                          |                                        2  1        1  1        2  1      |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Ectopic Tissue                       |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                                              2                    2      |             
      Hyperostosis                         |                                                                2         |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage, Focal                    |                            1                                             |             
      Meninges, Pigmentation, Hemosiderin  | 1                                                                        |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
      Degeneration                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  I  +|             
      Inflammation, Suppurative            |    2     2     1     1        2  1           1  1     1  1     1        1|             
      Metaplasia, Squamous                 |    1                                                                     |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           | 3  2                                                     3           3   |             
      Edema                                |                                              2                       3   |             
      Erythrophagocytosis                  |                                              2                           |             
      Hemorrhage                           |                                              3                 1  2      |             
      Infiltration Cellular, Histiocyte    |                                              2                    2     2|             
      Infiltration Cellular, Mixed Cell    |                                                                          |             
      Inflammation, Chronic, Focal         |                                              2                          2|             
      Metaplasia, Osseous                  |                                           1  1                           |             
      Alveolar Epithelium, Hyperplasia     | 2                                            1                    4      |             
      Artery, Mediastinum, Mineralization  |                                                                   2      |             
      Bronchiole, Inflammation, Suppurative|                                              2                           |             
      Perivascular, Infiltration Cellular, |                                                                          |             
           Mononuclear Cell                |       1  1        1           2        1        1     1        1         |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Inflammation, Suppurative            | 2                                   1     1     1     1        1  1  2   |             
      Thrombosis                           |                            3                       2                     |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |       2                                            2     1     4         |             
      Respiratory Epithelium, Hyperplasia  |          1                 1                 1                 1  1  1   |             
      Submucosa, Inflammation              | 2                 1     2     2  1  1  2  2     1     2        3     2   |             
      Vomeronasal Organ, Inflammation,     |                                                                          |             
           Suppurative                     |                                                                   1      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  34                                                               
NTP Experiment-Test: 05078-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 05/05/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:29:24  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 6| 5| 7| 7| 7| 7| 6| 6| 7| 7| 6| 5| 7| 6| 5| 6| 6| 5| 7| 6| 7| 5| 7|             
                             DAY ON TEST   | 2| 7| 7| 5| 2| 1| 2| 0| 2| 6| 2| 2| 8| 8| 0| 4| 8| 2| 1| 4| 2| 3| 1| 1| 0|             
                                           | 9| 9| 1| 2| 9| 6| 9| 9| 6| 4| 9| 9| 9| 1| 1| 6| 7| 1| 1| 9| 7| 3| 3| 9| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    15000 PP                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    M                                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            | 1                    1                 1                          2      |             
      Epithelium, Hyperplasia              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     | +                                   +     +                          +   |             
      Cataract                             |                                                                          |             
      Degeneration                         | 4                                                                        |             
      Inflammation, Chronic                |                                                                          |             
      Synechia                             | 2                                   3                                    |             
      Bilateral, Cataract                  | 3                                   2                                    |             
      Retina, Atrophy                      |                                     4                                    |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |          2                                                               |             
      Hydronephrosis                       |                                                                          |             
      Inflammation, Suppurative            |       1                       2           2                              |             
      Nephropathy                          | 3  2  3  1  3  3  3  3  3  3  4  4  4  2  3  4  2  1  3  2  3  1  4  3  3|             
      Pelvis, Epithelium, Hyperplasia      |                            2                 3                           |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Inflammation                         |                                                                          |             
      Inflammation, Suppurative            |                                                                   1      |             
      Transitional Epithelium, Hyperplasia |                                                                   2      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  35                                                               
NTP Experiment-Test: 05078-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 05/05/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:29:24  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 7| 5| 6| 6| 7| 7| 7| 5| 7| 6| 7| 6| 6| 7| 5| 6| 6| 5| 4| 5| 6| 4|            |
                             DAY ON TEST   | 2| 1| 0| 0| 7| 7| 2| 2| 2| 2| 7| 0| 0| 1| 1| 7| 0| 2| 4| 2| 6| 3| 8| 0| 7|            |
                                           | 8| 4| 7| 0| 7| 8| 6| 9| 9| 9| 7| 4| 2| 7| 3| 8| 9| 6| 6| 6| 2| 7| 7| 8| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    15000 PP                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    M                                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +|  43        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  A  +  +  +|  45        |
      Parasite Metazoan                    |                            X                          X                  |      4     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +|  45        |
      Parasite Metazoan                    |                            X  X                       X                  |      5     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +|  43        |
      Parasite Metazoan                    |                                                             X     X  X   |      5     |
      Serosa, Inflammation, Chronic        |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  A  +  +  +|  40        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                          |      1  3.0|
      Basophilic Focus                     |          1           1     1                                             |      7  1.0|
      Clear Cell Focus                     |                      1                                                   |      2  1.0|
      Congestion                           |                                                                          |      2  3.0|
      Degeneration, Cystic                 | 1                    2           1     1                                 |      9  1.6|
      Degeneration, Fatty                  |          1        2                                                      |      5  1.6|
      Degeneration                         |       2                                                                  |      2  2.0|
      Hematopoietic Cell Proliferation     |    1                                                                     |      3  1.3|
      Hepatodiaphragmatic Nodule           |                                                 X                        |      2     |
      Inflammation, Focal, Granulomatous   |                      2                                      1     1     1|      5  1.4|
      Necrosis                             | 1                                               2              2         |      4  1.8|
      Pigmentation                         |       2                                                                  |      1  2.0|
      Bile Duct, Hyperplasia               | 1  2  3     1        2  1     2  2  2     2        2  2  1  1  2     3  1|     34  1.7|
      Hepatocyte, Hyperplasia              |                      2        4        2  3  2                           |      8  2.4|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                 +                        |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atrophy                              | 1  2     1  1           1  1                 2  2                    4   |     17  1.5|
      Cytomegaly                           |                                                                          |      1  1.0|
      Inflammation                         |                                                                          |      1  1.0|
      Pigmentation, Hemosiderin            |                               2                                          |      1  2.0|
      Perivascular, Inflammation           |                            2              1                              |      3  2.0|
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                                                          |   1        |
      Inflammation, Suppurative            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Duct, Hyperplasia                    |       1  1              1        1                       1  1  1         |     15  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  36                                                               
NTP Experiment-Test: 05078-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 05/05/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:29:24  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 7| 5| 6| 6| 7| 7| 7| 5| 7| 6| 7| 6| 6| 7| 5| 6| 6| 5| 4| 5| 6| 4|            |
                             DAY ON TEST   | 2| 1| 0| 0| 7| 7| 2| 2| 2| 2| 7| 0| 0| 1| 1| 7| 0| 2| 4| 2| 6| 3| 8| 0| 7|            |
                                           | 8| 4| 7| 0| 7| 8| 6| 9| 9| 9| 7| 4| 2| 7| 3| 8| 9| 6| 6| 6| 2| 7| 7| 8| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    15000 PP                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    M                                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Duct, Inflammation, Suppurative      |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperkeratosis                       |                                                                2         |      1  2.0|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
      Ulcer                                |                                                                          |      1  3.0|
      Epithelium, Hyperplasia              |                   4                                                      |      2  3.5|
      Serosa, Inflammation, Chronic        |                   4                                                      |      1  4.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Erosion                              |                                                                          |      3  1.3|
      Hyperplasia, Lymphoid                |                                        2                                 |      1  2.0|
      Mineralization                       |                            2                                             |      2  2.5|
      Epithelium, Hyperplasia              |                                        1                                 |      1  1.0|
      Serosa, Inflammation, Chronic        |                   4                                                      |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                | 1  1  1  1  2     2  3  2  2  2  2  3  1  3  2  2  2  1     2  3  1     1|     46  1.9|
      Artery, Mineralization               |                                                                          |      1  2.0|
      Atrium, Thrombosis                   |                                                 3                        |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Degeneration, Fatty                  | 1              2  3  2     1        1  2        1        1     2         |     26  1.5|
      Hematopoietic Cell Proliferation     |          2                                                               |      2  1.5|
      Hyperplasia                          |    1           2                       3                                 |      6  2.5|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hematopoietic Cell Proliferation     |                                                                          |      1  1.0|
      Hyperplasia                          | 2     2                                         3     3              3   |     16  2.3|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  48        |
      Hyperplasia                          |                      2                                                   |      4  1.8|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  M  +  M|  41        |
      Hyperplasia                          |                            1                                             |      3  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Cyst                  |                                           2                              |      2  2.0|
      Pars Distalis, Hemorrhage            |       2                                                                  |      1  2.0|
      Pars Distalis, Hyperplasia           | 4     2                                   2  2  4  1                 2   |     10  2.3|
      Pars Distalis, Inflammation,         |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  37                                                               
NTP Experiment-Test: 05078-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 05/05/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:29:24  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 7| 5| 6| 6| 7| 7| 7| 5| 7| 6| 7| 6| 6| 7| 5| 6| 6| 5| 4| 5| 6| 4|            |
                             DAY ON TEST   | 2| 1| 0| 0| 7| 7| 2| 2| 2| 2| 7| 0| 0| 1| 1| 7| 0| 2| 4| 2| 6| 3| 8| 0| 7|            |
                                           | 8| 4| 7| 0| 7| 8| 6| 9| 9| 9| 7| 4| 2| 7| 3| 8| 9| 6| 6| 6| 2| 7| 7| 8| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    15000 PP                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    M                                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
          Suppurative                      |                            2                                             |      1  2.0|
      Pars Distalis, Pigmentation,         |                                                                          |            |
          Hemosiderin                      |                                  2                                       |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  47        |
      C-Cell, Hyperplasia                  | 1           3  1  1  1  1  3  4     1        2           2  2     1      |     23  1.6|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                  +                             +        +|   4        |
      Inflammation, Chronic                |                                                                3         |      1  3.0|
      Necrosis                             |                                                                3         |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  M  M  +  +  I  +  +  +  +  +  +  +  +  +  M  +  +  +|  42        |
      Granuloma Sperm                      |                                                                         2|      1  2.0|
      Vacuolization Cytoplasmic            | 1        2                                      3     3  2               |     15  1.9|
                                            __________________________________________________________________________|____________|
   Penis                                   |                                  +                                       |   1        |
      Inflammation, Suppurative            |                                  2                                       |      1  2.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
      Cyst                                 |                                                                          |      1  3.0|
      Inflammation, Suppurative            |                                     1                                    |      3  1.3|
      Duct, Hyperplasia                    |                                           2                              |      1  2.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +|  48        |
      Hyperplasia                          |                            1  1  1              2           1            |     11  1.5|
      Inflammation, Suppurative            |       2                    2  1     2  2                          1      |     13  1.7|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                                              +                          +|   6        |
      Inflammation, Suppurative            |                                              3                           |      5  1.6|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              | 2        3  2     4     4  1  4  1  4  2        3     3        4        3|     29  2.7|
      Interstitial Cell, Hyperplasia       |    1  1        1     1              2     1  1     1           1  1      |     15  1.3|
      Perivascular, Inflammation           |                   1        2                                             |      8  2.1|
      Tunic, Hyperplasia                   |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                  +  +  +     +                           |   4        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hyperplasia                          |                                                                          |      1  2.0|
      Myelofibrosis                        |                                                       2                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mesenteric, Inflammation,            |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  38                                                               
NTP Experiment-Test: 05078-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 05/05/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:29:24  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 7| 5| 6| 6| 7| 7| 7| 5| 7| 6| 7| 6| 6| 7| 5| 6| 6| 5| 4| 5| 6| 4|            |
                             DAY ON TEST   | 2| 1| 0| 0| 7| 7| 2| 2| 2| 2| 7| 0| 0| 1| 1| 7| 0| 2| 4| 2| 6| 3| 8| 0| 7|            |
                                           | 8| 4| 7| 0| 7| 8| 6| 9| 9| 9| 7| 4| 2| 7| 3| 8| 9| 6| 6| 6| 2| 7| 7| 8| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    15000 PP                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    M                                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
          Granulomatous                    |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hyperplasia                          |                                                                         2|      2  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  M  M  M  +  M  +  +  +  +  +  +  +  +  M  +  M  M  +  +  +  M|  38        |
      Angiectasis                          |          2                             2                                 |      2  2.0|
      Hyperplasia                          |                                  2     2                       2  1      |     11  2.1|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             | 2        2                    1                                          |      9  1.7|
      Hematocyst                           |                                                                          |      1  3.0|
      Hematopoietic Cell Proliferation     |    2                                                                     |      2  2.5|
                                            __________________________________________________________________________|____________|
   Thymus                                  | I  +  M  +  +  M  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  41        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  +  +  M  M  M  M  M  M  M  M  M  +  +  M  M  M  M  M  M  +  M  +  M  M|  14        |
      Galactocele                          |                                                             1            |      3  1.0|
      Hyperplasia                          |    1  1                                2                          1      |     10  1.3|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +|  46        |
      Ectopic Tissue                       |                   X                                                      |      1     |
      Inflammation, Chronic                |    4                                                                     |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +|  49        |
      Fibrous Osteodystrophy               |                            2                                   2         |      4  2.0|
      Hyperostosis                         |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage, Focal                    |       1                                                        3         |      3  1.7|
      Meninges, Pigmentation, Hemosiderin  |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                  +                                       |   1        |
      Degeneration                         |                                  2                                       |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  I  +  +  +  +  +  +|  44        |
      Inflammation, Suppurative            |    1  1     1  1     1     1  2           1     1                        |     21  1.2|
      Metaplasia, Squamous                 |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                           3                              |      5  2.8|
      Edema                                |                                                                          |      2  2.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  39                                                               
NTP Experiment-Test: 05078-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 05/05/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:29:24  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 7| 5| 6| 6| 7| 7| 7| 5| 7| 6| 7| 6| 6| 7| 5| 6| 6| 5| 4| 5| 6| 4|            |
                             DAY ON TEST   | 2| 1| 0| 0| 7| 7| 2| 2| 2| 2| 7| 0| 0| 1| 1| 7| 0| 2| 4| 2| 6| 3| 8| 0| 7|            |
                                           | 8| 4| 7| 0| 7| 8| 6| 9| 9| 9| 7| 4| 2| 7| 3| 8| 9| 6| 6| 6| 2| 7| 7| 8| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    15000 PP                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    M                                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Erythrophagocytosis                  |                                                                          |      1  2.0|
      Hemorrhage                           |                                                                          |      3  2.0|
      Infiltration Cellular, Histiocyte    | 1     1  1           1     1     1     2        1     3     1            |     13  1.5|
      Infiltration Cellular, Mixed Cell    |    2                                                                     |      1  2.0|
      Inflammation, Chronic, Focal         |                                                                          |      2  2.0|
      Metaplasia, Osseous                  |                                                                          |      2  1.0|
      Alveolar Epithelium, Hyperplasia     |                      4                       4  2        4               |      7  3.0|
      Artery, Mediastinum, Mineralization  |                                                                          |      1  2.0|
      Bronchiole, Inflammation, Suppurative|                                                                          |      1  2.0|
      Perivascular, Infiltration Cellular, |                                                                          |            |
           Mononuclear Cell                |    1  1     1     1        1              1                              |     14  1.1|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Suppurative            |             1  1     1     1                                            2|     13  1.2|
      Thrombosis                           |       1                                         2     2        2        1|      7  1.9|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |       2                                1        2                    1   |      8  1.9|
      Respiratory Epithelium, Hyperplasia  |       1              1  1  1           2     1                 1        1|     14  1.1|
      Submucosa, Inflammation              | 2           1  2     1  2  1              1  2     1        1           2|     23  1.6|
      Vomeronasal Organ, Inflammation,     |                                                                          |            |
           Suppurative                     |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Suppurative            |                1        1        1                                       |      7  1.1|
      Epithelium, Hyperplasia              |                1                                                         |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                  +           +     +                     |   7        |
      Cataract                             |                                              3                           |      1  3.0|
      Degeneration                         |                                                                          |      1  4.0|
      Inflammation, Chronic                |                                                    4                     |      1  4.0|
      Synechia                             |                                  3           4                           |      4  3.0|
      Bilateral, Cataract                  |                                  3                                       |      3  2.7|
      Retina, Atrophy                      |                                  3           4                           |      3  3.7|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hematopoietic Cell Proliferation     | 1                       1                                                |      3  1.3|
      Hydronephrosis                       |                                                                         2|      1  2.0|
      Inflammation, Suppurative            |                                                                          |      3  1.7|
      Nephropathy                          | 3     2  2  2  2  4  3  4  4  2  2  1  3  2  3  3  2  2  3  2  2  3  2  1|     49  2.6|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  40                                                               
NTP Experiment-Test: 05078-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           ETHYL CHLORIDE                                      Date: 05/05/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:29:24  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 7| 5| 6| 6| 7| 7| 7| 5| 7| 6| 7| 6| 6| 7| 5| 6| 6| 5| 4| 5| 6| 4|            |
                             DAY ON TEST   | 2| 1| 0| 0| 7| 7| 2| 2| 2| 2| 7| 0| 0| 1| 1| 7| 0| 2| 4| 2| 6| 3| 8| 0| 7|            |
                                           | 8| 4| 7| 0| 7| 8| 6| 9| 9| 9| 7| 4| 2| 7| 3| 8| 9| 6| 6| 6| 2| 7| 7| 8| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    15000 PP                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    M                                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Pelvis, Epithelium, Hyperplasia      |                      2                                                   |      3  2.3|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hemorrhage                           |                                  2                                       |      1  2.0|
      Inflammation                         |                                  2                                       |      1  2.0|
      Inflammation, Suppurative            |                                                                          |      1  1.0|
      Transitional Epithelium, Hyperplasia |                                  2                                       |      2  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  41                                                               
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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.