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TR 346 Rat Pathology Tables

NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11 
LAB: Battelle Northwest                                        DATE: 09/10/94   
EXP: 05078                      ETHYL CHLORIDE                 TIME: 13:14:15   
TEST: 01              CAGES FROM 0000 TO LAST CAGE             PAGE:   1        
TEST TYPE: CHRONIC          ROUTE: RESPIRATORY EXPOSURE WHOLE  NTP C#: 06224    
CONT: N01ES38061                                               CAS: 75-00-3     
PATHOLOGIST: R. MILLER                                                          
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NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11
LAB: Battelle Northwest                                        DATE: 09/10/94  
EXP: 05078                      ETHYL CHLORIDE                 TIME: 13:14:15  
TEST: 01              CAGES FROM 0000 TO LAST CAGE                             
TEST TYPE: CHRONIC          ROUTE: RESPIRATORY EXPOSURE WHOLE  NTP C#: 06224   
CONT: N01ES38061                                               CAS: 75-00-3    
PATHOLOGIST: R. MILLER                                                         

                                  ETHYL CHLORIDE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = CONTROL                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 34     CENSORED DEATHS 0    TERMINAL 16        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      485   500   512   517   526   526   542   545   567   570                 |
 |      570   587   611   641   645   646   654   654   658   665                 |
 |      668   671   672   675   682   682   689   692   696   696                 |
 |      698   699   717   720                                                     |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 15000 PPM                                |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 42     CENSORED DEATHS 0    TERMINAL 8         |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      414   437   471   479   519   526   549   552   562   577                 |
 |      577   581   587   587   602   608   611   613   621   626                 |
 |      626   626   633   646   646   664   671   678   678   689                 |
 |      700   701   704   706   707   709   709   713   716   717                 |
 |      727   728                                                                 |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================

                                  ETHYL CHLORIDE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   729 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |CONTROL    |   100.0 100.0 100.0 100.0 100.0  98.0  84.0  76.0  60.0  32.0      |
 |           |                                                                    |
 |           |                                                                    |
 |15000 PPM  |   100.0 100.0 100.0 100.0  98.0  92.0  88.0  70.0  48.0  16.0      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                        DOSE                    |
 |                                                                                |
 |                                CONTROL                   15000 PPM             |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       32.0%                     16.0%                 |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.161                   P=0.161               |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       625.8                     623.6                 |
 |NATURAL DEATHS (C)      |       (12.4)                    (12.7)                |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       658.8                     640.5                 |
 |(STANDARD ERROR)        |       (10.8)                    (12.0)                |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                  ETHYL CHLORIDE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = CONTROL                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 19     CENSORED DEATHS 0    TERMINAL 31        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      251   540   545   568   574   587   611   630   633   643                 |
 |      654   657   659   659   661   668   688   703   716                       |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 15000 PPM                                |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 28     CENSORED DEATHS 0    TERMINAL 22        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      364   490   535   545   546   559   563   573   573   574                 |
 |      588   594   599   608   612   622   623   629   643   650                 |
 |      672   679   688   688   689   707   714   720                             |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================

                                  ETHYL CHLORIDE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   729 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |CONTROL    |   100.0 100.0  98.0  98.0  98.0  98.0  94.0  88.0  70.0  62.0      |
 |           |                                                                    |
 |           |                                                                    |
 |15000 PPM  |   100.0 100.0 100.0  98.0  98.0  98.0  92.0  74.0  60.0  44.0      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                        DOSE                    |
 |                                                                                |
 |                                CONTROL                   15000 PPM             |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       62.0%                     44.0%                 |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.083                   P=0.083               |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       613.0                     608.8                 |
 |NATURAL DEATHS (C)      |       (23.2)                    (14.6)                |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       684.9                     661.7                 |
 |(STANDARD ERROR)        |       (11.8)                    (11.8)                |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                                           ETHYL CHLORIDE
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        CONTROL          = 1
                                                        15000 PPM        = 2

------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1                                                                 2          1
      |                                                                   2  2       1 1
      |                                                                      2     22  1 1
      |                                                                             2    1 21
   90 +                                                                                    22
      |                                                                                     1 12
      |                                                                                       12 1
      |                                                                                          112
   80 +
      |                                                                                           1 1
P     |                                                                                            21    1   1
E     |                                                                                             2  2     11
R  70 +                                                                                                22
C     |                                                                                                 22    11
E     |                                                                                                  22
N     |                                                                                                   22   1 1
T  60 +                                                                                                          11
      |
S     |                                                                                                    22 2   11
U     |                                                                                                            11
R  50 +                                                                                                       2  2
V     |                                                                                                          22 11
I     |                                                                                                           22 11
V     |                                                                                                            2 2
A  40 +                                                                                                              22
L     |                                                                                                               22
      |                                                                                                               1  1
      |                                                                                                                  1  1
   30 +                                                                                                                22
      |
      |                                                                                                                 22
      |
   20 +                                                                                                                  22
      |
      |                                                                                                                   2 2
      |
   10 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 8 obs hidden.

                                                           ETHYL CHLORIDE
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        CONTROL          = 1
                                                        15000 PPM        = 2

----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1                                       1                2
      |                                         1                2                   2        1
      |                                                                              2       21   1
      |
P  90 +                                                                                       2 2 1 1
E     |                                                                                         22  1    1
R     |                                                                                          22      1 11
C     |                                                                                                     11
E  80 +                                                                                           2 2        1 1
N     |                                                                                             2 2
T     |                                                                                               222      1 1
      |                                                                                                 22
S  70 +                                                                                                  22      11
U     |                                                                                                           1  1
R     |                                                                                                   22 2       1 1 1
V     |                                                                                                      22          1  1
I  60 +                                                                                                       2   2
V     |                                                                                                           22
A     |                                                                                                            2 2
L     |
   50 +                                                                                                              2 2
      |                                                                                                                22
      |                                                                                                                 22  2
      |
   40 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 8 obs hidden.

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