National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/2099

TR 349 Mouse Pathology Tables

NTP Experiment-Test: 05073-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 PENTACHLOROPHENOL, TECHNICAL GRADE                            Date: 05/05/97
Route: DOSED FEED                                                                                                 Time: 13:53:04




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  87-86-5

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































Note:  Animals arranged according to CID number

                                                              Page   1

NTP Experiment-Test: 05073-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 PENTACHLOROPHENOL, TECHNICAL GRADE                            Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 13:53:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 2| 3| 3| 2| 3| 2| 5| 3| 3| 3| 2| 3| 3| 3| 2| 3| 3| 3| 3| 2| 7| 2| 3| 3|             
                                           | 0| 9| 0| 0| 9| 0| 9| 3| 1| 0| 1| 9| 5| 1| 1| 9| 1| 0| 1| 0| 9| 4| 9| 0| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  A  M  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Adenoma               |                X              X                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                      X   |             
      Sarcoma, Metastatic, Uncertain       |                                                                          |             
          Primary Site                     |    X                                                                     |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +                                            +                        |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Sarcoma, Metastatic, Uncertain       |                                                                          |             
          Primary Site                     |    X                                                                     |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                               X                                          |             
      Sarcoma, Metastatic, Uncertain       |                                                                          |             
          Primary Site                     |    X                                                                     |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Squamous Cell Papilloma              |                               X              X                    X      |             
      Squamous Cell Papilloma, Multiple    |                                                                         X|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Sarcoma, Metastatic, Uncertain       |                                                                          |             
          Primary Site                     |    X                                                                     |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                        X                                 |             
      Sarcoma, Metastatic, Uncertain       |                                                                          |             
          Primary Site                     |    X                                                                     |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pheochromocytoma Malignant           |                                                             X            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05073-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 PENTACHLOROPHENOL, TECHNICAL GRADE                            Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 13:53:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 2| 3| 3| 2| 3| 2| 5| 3| 3| 3| 2| 3| 3| 3| 2| 3| 3| 3| 3| 2| 7| 2| 3| 3|             
                                           | 0| 9| 0| 0| 9| 0| 9| 3| 1| 0| 1| 9| 5| 1| 1| 9| 1| 0| 1| 0| 9| 4| 9| 0| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Pars Distalis, Adenoma               |       X        X  X           X        X        X  X                     |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  M  +  +  +  I  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                  X                                       |             
      Luteoma                              |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                               X                    X                     |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Sarcoma, Metastatic, Uncertain       |                                                                          |             
          Primary Site                     |    X                                                                     |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femoral, Lymphoma Malignant          |                                                                          |             
          Lymphocytic                      |                               X                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bronchial, Lymphoma Malignant        |                                                                          |             
          Lymphocytic                      |                                        X                                 |             
      Inguinal, Lymphoma Malignant         |                                                                          |             
          Lymphocytic                      |                                     X                                    |             
      Lumbar, Lymphoma Malignant           |                                                                          |             
          Lymphocytic                      |                         X                                                |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Histiocytic                      |                                                                          |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Lymphocytic                      |                                     X  X                                 |             
      Mediastinal, Lymphoma Malignant Mixed|                                                                          |             
      Mediastinal, Sarcoma, Metastatic,    |                                                                          |             
           Uncertain Primary Site          |    X                                                                     |             
      Mesenteric, Lymphoma Malignant       |                                                                          |             
          Histiocytic                      |                                                                          |             
      Mesenteric, Lymphoma Malignant       |                                                                          |             
          Lymphocytic                      |       X                       X     X  X                                 |             
      Pancreatic, Lymphoma Malignant       |                                                                          |             
          Lymphocytic                      |                                                    X                     |             
      Renal, Lymphoma Malignant Histiocytic|                                                                          |             
      Renal, Lymphoma Malignant Lymphocytic|                                     X                                    |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05073-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 PENTACHLOROPHENOL, TECHNICAL GRADE                            Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 13:53:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 2| 3| 3| 2| 3| 2| 5| 3| 3| 3| 2| 3| 3| 3| 2| 3| 3| 3| 3| 2| 7| 2| 3| 3|             
                                           | 0| 9| 0| 0| 9| 0| 9| 3| 1| 0| 1| 9| 5| 1| 1| 9| 1| 0| 1| 0| 9| 4| 9| 0| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Renal, Lymphoma Malignant Mixed      |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |       X                 X     X     X  X           X                 X   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |       X                 X  X  X     X  X           X                 X   |             
      Sarcoma, Metastatic, Uncertain       |                                                                          |             
          Primary Site                     |    X                                                                     |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  M  M  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                         X                                                |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma                       |                         X                 X        X                     |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Carcinoma       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Sarcoma, Metastatic, Uncertain       |                                                                          |             
          Primary Site                     |    X                                                                     |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |             X                                                            |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                         X     X        X                                 |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Sarcoma, Metastatic, Uncertain       |                                                                          |             
          Primary Site                     |    X                                                                     |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Sarcoma, Metastatic, Uncertain       |                                                                          |             
          Primary Site                     |    X                                                                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05073-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 PENTACHLOROPHENOL, TECHNICAL GRADE                            Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 13:53:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 2| 3| 3| 2| 3| 2| 5| 3| 3| 3| 2| 3| 3| 3| 2| 3| 3| 3| 3| 2| 7| 2| 3| 3|             
                                           | 0| 9| 0| 0| 9| 0| 9| 3| 1| 0| 1| 9| 5| 1| 1| 9| 1| 0| 1| 0| 9| 4| 9| 0| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |       X                 X  X  X     X  X           X                 X   |             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05073-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 PENTACHLOROPHENOL, TECHNICAL GRADE                            Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 13:53:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 7| 6| 1| 7| 7|                                            |            |
                             DAY ON TEST   | 2| 3| 2| 0| 2| 3| 3| 8| 3| 3|                                            |            |
                                           | 9| 1| 9| 5| 9| 0| 5| 3| 0| 1|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |     A      |
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  A  M  +  +                                             |  33        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  A  A  +  +  A  A  +  +                                             |  29        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  A  +  +  +  M  +  +  +                                             |  32        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  A  +  +  +  M  +  +  +                                             |  30        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  A  +  +  +  M  +  +  +                                             |  32        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  A  +  +  +  M  +  +  +                                             |  31        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  A  +  +  +  M  +  +  +                                             |  32        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  A  +  +  +  M  +  +  +                                             |  32        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  A  +  +  +  M  +  +  +                                             |  31        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  A  +  +  +  M  +  +  +                                             |  32        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  A  +  +  +  A  +  +  +                                             |  33        |
      Hepatocellular Adenoma               |                            X                                             |          3 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Sarcoma, Metastatic, Uncertain       |                                                                          |            |
          Primary Site                     |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               | +                                                                        |   3        |
      Lymphoma Malignant Lymphocytic       | X                                                                        |          1 |
      Sarcoma, Metastatic, Uncertain       |                                                                          |            |
          Primary Site                     |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  A  I  +  +  M  +  +  +                                             |  31        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Sarcoma, Metastatic, Uncertain       |                                                                          |            |
          Primary Site                     |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  A  +  +  +  +  M  +  +                                             |  33        |
      Lymphoma Malignant Lymphocytic       |    X        X                                                            |          2 |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  A  +  +  +  M  +  +  +                                             |  32        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  A  +  +  +  M  +  +  +                                             |  32        |
      Squamous Cell Papilloma              |                            X                                             |          4 |
      Squamous Cell Papilloma, Multiple    |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  A  +  +  +  M  +  +  +                                             |  32        |
      Sarcoma, Metastatic, Uncertain       |                                                                          |            |
          Primary Site                     |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  35        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  M  +  +  +                                             |  34        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  A  +  +  +  M  +  +  +                                             |  33        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page   6                                                               
NTP Experiment-Test: 05073-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 PENTACHLOROPHENOL, TECHNICAL GRADE                            Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 13:53:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 7| 6| 1| 7| 7|                                            |            |
                             DAY ON TEST   | 2| 3| 2| 0| 2| 3| 3| 8| 3| 3|                                            |            |
                                           | 9| 1| 9| 5| 9| 0| 5| 3| 0| 1|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |     A      |
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Adenoma                              |                                                                          |          1 |
      Sarcoma, Metastatic, Uncertain       |                                                                          |            |
          Primary Site                     |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  A  +  +  +  M  +  +  +                                             |  33        |
      Pheochromocytoma Malignant           |          X                                                               |          2 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  A  I  +  +  M  +  +  +                                             |  31        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  M  M  +  +                                             |  30        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  M  +  +  +                                             |  32        |
      Pars Distalis, Adenoma               |       X  X  X              X                                             |         11 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  M  M  +  +                                             |  33        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  A  +  +  +  M  +  +  +                                             |  30        |
      Adenoma                              |                            X                                             |          2 |
      Luteoma                              |                         X                                                |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  A  +  +  +  M  +  +  +                                             |  33        |
      Sarcoma, Metastatic, Uncertain       |                                                                          |            |
          Primary Site                     |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  35        |
      Femoral, Lymphoma Malignant          |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  M  +  +  +  +  M  +  +                                             |  33        |
      Bronchial, Lymphoma Malignant        |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
      Inguinal, Lymphoma Malignant         |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
      Lumbar, Lymphoma Malignant           |                                                                          |            |
          Lymphocytic                      |                X                                                         |          2 |
      Mediastinal, Lymphoma Malignant      |                                                                          |            |
          Histiocytic                      |                   X                                                      |          1 |
      Mediastinal, Lymphoma Malignant      |                                                                          |            |
          Lymphocytic                      |             X  X                                                         |          4 |
      Mediastinal, Lymphoma Malignant Mixed|                         X                                                |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page   7                                                               
NTP Experiment-Test: 05073-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 PENTACHLOROPHENOL, TECHNICAL GRADE                            Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 13:53:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 7| 6| 1| 7| 7|                                            |            |
                             DAY ON TEST   | 2| 3| 2| 0| 2| 3| 3| 8| 3| 3|                                            |            |
                                           | 9| 1| 9| 5| 9| 0| 5| 3| 0| 1|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |     A      |
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Mediastinal, Sarcoma, Metastatic,    |                                                                          |            |
           Uncertain Primary Site          |                                                                          |          1 |
      Mesenteric, Lymphoma Malignant       |                                                                          |            |
          Histiocytic                      |                   X                                                      |          1 |
      Mesenteric, Lymphoma Malignant       |                                                                          |            |
          Lymphocytic                      | X           X  X                                                         |          7 |
      Pancreatic, Lymphoma Malignant       |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
      Renal, Lymphoma Malignant Histiocytic|                   X                                                      |          1 |
      Renal, Lymphoma Malignant Lymphocytic|                X                                                         |          2 |
      Renal, Lymphoma Malignant Mixed      |                         X                                                |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  M  +  +  +  +  M  +  +                                             |  33        |
      Lymphoma Malignant Histiocytic       |                   X                                                      |          1 |
      Lymphoma Malignant Lymphocytic       | X  X        X  X                                                         |         11 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  A  +  +  +  A  +  +  +                                             |  33        |
      Lymphoma Malignant Lymphocytic       | X  X        X  X                                                         |         12 |
      Sarcoma, Metastatic, Uncertain       |                                                                          |            |
          Primary Site                     |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  M  +  +  +  +  M  M  +                                             |  28        |
      Lymphoma Malignant Histiocytic       |                   X                                                      |          1 |
      Lymphoma Malignant Lymphocytic       |             X  X                                                         |          3 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  A  +  +  +  M  M  +  +                                             |  30        |
      Adenocarcinoma                       |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  A  +  +  +  A  +  +  +                                             |  33        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  35        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  A  +  +  +  A  +  +  +                                             |  33        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  35        |
      Alveolar/Bronchiolar Carcinoma       |       X                                                                  |          1 |
      Lymphoma Malignant Lymphocytic       |             X                                                            |          1 |
      Sarcoma, Metastatic, Uncertain       |                                                                          |            |
          Primary Site                     |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page   8                                                               
NTP Experiment-Test: 05073-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 PENTACHLOROPHENOL, TECHNICAL GRADE                            Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 13:53:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 7| 6| 1| 7| 7|                                            |            |
                             DAY ON TEST   | 2| 3| 2| 0| 2| 3| 3| 8| 3| 3|                                            |            |
                                           | 9| 1| 9| 5| 9| 0| 5| 3| 0| 1|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |     A      |
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  35        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  A  M  +  +                                             |  33        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +  +  A  +  +  +  +  +  +  +                                             |  32        |
      Adenoma                              |             X                                                            |          2 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  A  +  +  +  A  +  +  +                                             |  33        |
      Lymphoma Malignant Lymphocytic       |    X        X  X                                                         |          6 |
      Lymphoma Malignant Mixed             |                         X                                                |          1 |
      Sarcoma, Metastatic, Uncertain       |                                                                          |            |
          Primary Site                     |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  A  +  +  +  M  +  +  +                                             |  32        |
      Sarcoma, Metastatic, Uncertain       |                                                                          |            |
          Primary Site                     |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +                                             |  35        |
      Lymphoma Malignant Histiocytic       |                   X                                                      |          1 |
      Lymphoma Malignant Lymphocytic       | X  X        X  X                                                         |         12 |
      Lymphoma Malignant Mixed             |                         X                                                |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page   9                                                               
NTP Experiment-Test: 05073-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 PENTACHLOROPHENOL, TECHNICAL GRADE                            Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 13:53:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 3| 3| 3| 3| 2| 3| 3| 7| 3| 3| 2| 2| 2| 3| 2| 3| 3| 5| 3| 3| 3| 2| 3| 3|             
                                           | 9| 0| 1| 0| 1| 9| 0| 1| 5| 0| 0| 9| 9| 9| 1| 9| 0| 1| 6| 0| 1| 0| 9| 0| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    100 PPM                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |                                                                          |             
                                            __________________________________________________________________________|             
   Gallbladder                             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         |                   +                                                      |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |                   +                                                      |             
      Peyer's Patch, Lymphoma Malignant    |                                                                          |             
          Lymphocytic                      |                   X                                                      |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                   +                                                      |             
      Peyer's Patch, Lymphoma Malignant    |                                                                          |             
          Lymphocytic                      |                   X                                                      |             
      Peyer's Patch, Lymphoma Malignant    |                                                                          |             
          Mixed                            |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosarcoma, Metastatic             |                                                                          |             
      Hemangiosarcoma, Multiple            | X                                                                        |             
      Hepatocellular Carcinoma             |                                                                          |             
      Hepatocellular Adenoma               |    X                          X        X                             X  X|             
      Hepatocellular Adenoma, Multiple     |                X                                                         |             
      Ito Cell Tumor Benign, Multiple      | X                                                                        |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Fibrosarcoma, Metastatic             |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |                                                       +                  |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pheochromocytoma Benign              |                                        X                                 |             
      Bilateral, Pheochromocytoma Benign   |                   X                                                      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  10                                                               
NTP Experiment-Test: 05073-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 PENTACHLOROPHENOL, TECHNICAL GRADE                            Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 13:53:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 3| 3| 3| 3| 2| 3| 3| 7| 3| 3| 2| 2| 2| 3| 2| 3| 3| 5| 3| 3| 3| 2| 3| 3|             
                                           | 9| 0| 1| 0| 1| 9| 0| 1| 5| 0| 0| 9| 9| 9| 1| 9| 0| 1| 6| 0| 1| 0| 9| 0| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    100 PPM                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |          +  +  +  +           +  +                    +        +        +|             
      Pars Distalis, Adenoma               |          X     X  X           X  X                             X        X|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +     +     +  +  +  +  +  +  I     +     +  +              +            |             
      Adenoma                              |                                                             X            |             
      Carcinoma                            |                                                                          |             
      Luteoma                              |             X                                                            |             
                                            __________________________________________________________________________|             
   Uterus                                  |    +  +  +  +     +  +     +           +  +  +  +  +  +  +  +     +  +  +|             
      Polyp Stromal                        |          X                                                               |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +           +        +                                                   |             
      Mesenteric, Lymphoma Malignant       |                                                                          |             
          Histiocytic                      |                                                                          |             
      Mesenteric, Lymphoma Malignant       |                                                                          |             
          Lymphocytic                      |                      X                                                   |             
      Mesenteric, Lymphoma Malignant Mixed |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +              +        +                             +                  |             
      Fibrosarcoma                         | X                                                                        |             
      Hemangiosarcoma                      |                X                                                         |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |                                                                          |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |                                     +                 +                  |             
      Adenocarcinoma                       |                                     X                 X                  |             
                                            __________________________________________________________________________|             
   Skin                                    |                                                                          |             
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  11                                                               
NTP Experiment-Test: 05073-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 PENTACHLOROPHENOL, TECHNICAL GRADE                            Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 13:53:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 3| 3| 3| 3| 2| 3| 3| 7| 3| 3| 2| 2| 2| 3| 2| 3| 3| 5| 3| 3| 3| 2| 3| 3|             
                                           | 9| 0| 1| 0| 1| 9| 0| 1| 5| 0| 0| 9| 9| 9| 1| 9| 0| 1| 6| 0| 1| 0| 9| 0| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    100 PPM                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |                                              +                           |             
      Alveolar/Bronchiolar Adenoma         |                                              X                           |             
                                            __________________________________________________________________________|             
   Nose                                    |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                   X  X                                                   |             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  12                                                               
NTP Experiment-Test: 05073-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 PENTACHLOROPHENOL, TECHNICAL GRADE                            Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 13:53:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 7| 7| 7| 6| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 4|            |
                             DAY ON TEST   | 2| 2| 3| 3| 2| 3| 9| 3| 2| 8| 3| 2| 3| 2| 3| 0| 3| 2| 3| 0| 3| 5| 3| 3| 7|            |
                                           | 9| 4| 0| 0| 9| 1| 2| 1| 9| 2| 1| 9| 1| 9| 0| 5| 1| 9| 1| 7| 1| 3| 0| 0| 6|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     A      |
    100 PPM                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |    +                       +                                   +        +|   4        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |    A                       A                                   M        A|            |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |    A                       +                                   +        +|   3        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |    A                       +                                   +        A|   2        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |    A                       +                                   +        +|   3        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |    A                       +                                   M        +|   2        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |    A                       +              +                    +        +|   5        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |    A                       +                                   +        +|   3        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |    A                       A                                   M        A|   1        |
      Peyer's Patch, Lymphoma Malignant    |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |    A                       +              +                    +        +|   5        |
      Peyer's Patch, Lymphoma Malignant    |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
      Peyer's Patch, Lymphoma Malignant    |                                                                          |            |
          Mixed                            |                                           X                              |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Fibrosarcoma, Metastatic             |                                              X                           |          1 |
      Hemangiosarcoma, Multiple            |    X                                                                     |          2 |
      Hepatocellular Carcinoma             |                                                          X               |          1 |
      Hepatocellular Adenoma               |                               X     X                                    |          7 |
      Hepatocellular Adenoma, Multiple     |                                                                          |          1 |
      Ito Cell Tumor Benign, Multiple      |                                                                          |          1 |
      Lymphoma Malignant Histiocytic       |                   X                                                      |          1 |
      Lymphoma Malignant Lymphocytic       |             X                                                            |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                              +                           |   1        |
      Fibrosarcoma, Metastatic             |                                              X                           |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                |    A                       +                                   +        +|   4        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |    +                       +                                   +        +|   4        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |    A                       +                                   +        +|   3        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |    A                       +                                   +        +|   3        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |    A                       +                                   +        +|   3        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |    +                       +                                   +        +|   4        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  13                                                               
NTP Experiment-Test: 05073-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 PENTACHLOROPHENOL, TECHNICAL GRADE                            Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 13:53:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 7| 7| 7| 6| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 4|            |
                             DAY ON TEST   | 2| 2| 3| 3| 2| 3| 9| 3| 2| 8| 3| 2| 3| 2| 3| 0| 3| 2| 3| 0| 3| 5| 3| 3| 7|            |
                                           | 9| 4| 0| 0| 9| 1| 2| 1| 9| 2| 1| 9| 1| 9| 0| 5| 1| 9| 1| 7| 1| 3| 0| 0| 6|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     A      |
    100 PPM                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Pheochromocytoma Benign              |                                                                          |          1 |
      Bilateral, Pheochromocytoma Benign   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |    A                       +                                   +        +|   3        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |    +                       +                                   +        +|   4        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |    M  +                 +  M        +                          +        +|  14        |
      Pars Distalis, Adenoma               |                                     X                                    |          8 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |    +                       +                                   +        +|   4        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   |    +  +     +  +        +  +           +        +  +           +        +|  23        |
      Adenoma                              |                                                                          |          1 |
      Carcinoma                            |                            X                                             |          1 |
      Luteoma                              |                         X                                                |          2 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +     +     +  +  +  +  +        +  +  +     +  +  +     +|  37        |
      Polyp Stromal                        |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |    +                       +                                   +        +|   4        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +              +        +        +     +                    +  +     +|  12        |
      Mesenteric, Lymphoma Malignant       |                                                                          |            |
          Histiocytic                      |                   X                                                      |          1 |
      Mesenteric, Lymphoma Malignant       |                                                                          |            |
          Lymphocytic                      | X                                                                 X      |          3 |
      Mesenteric, Lymphoma Malignant Mixed |                                           X                              |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |    +                       +                                   +        +|   4        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +        +              +              +        +           +  +     +|  13        |
      Fibrosarcoma                         |                                                                          |          1 |
      Hemangiosarcoma                      |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       | X           X                                      X              X      |          4 |
      Lymphoma Malignant Mixed             |                                           X                              |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  |    M              +        M                                   +        M|   2        |
      Lymphoma Malignant Histiocytic       |                   X                                                      |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |    M                       M                                   +        M|   3        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  14                                                               
NTP Experiment-Test: 05073-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 PENTACHLOROPHENOL, TECHNICAL GRADE                            Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 13:53:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 7| 7| 7| 6| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 4|            |
                             DAY ON TEST   | 2| 2| 3| 3| 2| 3| 9| 3| 2| 8| 3| 2| 3| 2| 3| 0| 3| 2| 3| 0| 3| 5| 3| 3| 7|            |
                                           | 9| 4| 0| 0| 9| 1| 2| 1| 9| 2| 1| 9| 1| 9| 0| 5| 1| 9| 1| 7| 1| 3| 0| 0| 6|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     A      |
    100 PPM                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Adenocarcinoma                       |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Skin                                    |    +                       +                 +                 +        +|   5        |
      Subcutaneous Tissue, Fibrosarcoma    |                                              X                           |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |    +                       +                                   +        +|   4        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |    +              A        +                                   +        +|   4        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |    +                       +                                   +        +|   5        |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    |    +                       +                                   +        +|   4        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |    +                       +                                   +        +|   4        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |    +                       +                                   +        +|   4        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +              +        +        +                          +        +|   7        |
      Lymphoma Malignant Lymphocytic       | X                                                                        |          1 |
      Lymphoma Malignant Mixed             |                                     X                                    |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |    A                       +                                   +        +|   3        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Histiocytic       |                   X                                                      |          1 |
      Lymphoma Malignant Lymphocytic       | X           X                                      X              X      |          6 |
      Lymphoma Malignant Mixed             |                                     X     X                              |          2 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  15                                                               
NTP Experiment-Test: 05073-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 PENTACHLOROPHENOL, TECHNICAL GRADE                            Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 13:53:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 4| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 3| 3| 2| 1| 7| 1| 3| 3| 3| 3| 3| 9| 8| 3| 2| 9| 2| 3| 1| 2| 2| 3| 3| 9| 3|             
                                           | 4| 1| 9| 0| 3| 8| 0| 0| 1| 0| 1| 5| 2| 0| 9| 4| 9| 0| 1| 9| 9| 1| 0| 5| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    200 PPM                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | A  +  +  +  +  A  +  +  +  +  +  A  A  +  +  +  +  M  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Peyer's Patch, Lymphoma Malignant    |                                                                          |             
          Mixed                            |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                                          |             
      Hemangiosarcoma, Multiple            |          X                                   X        X                  |             
      Hepatocellular Carcinoma             |             X                                                            |             
      Hepatocellular Adenoma               |                   X                 X                       X     X      |             
      Hepatocellular Adenoma, Multiple     |                                                                          |             
      Lymphoma Malignant Histiocytic       | X                                         X                              |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                        X                                 |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                        X                                 |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pheochromocytoma Benign              |       X                                                                  |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  M  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  M  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | M  +  +  +  +  +  +  +  M  +  +  +  +  I  +  +  +  +  +  +  M  +  M  +  M|             
      Pars Distalis, Adenoma               |                               X                       X              X   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  16                                                               
NTP Experiment-Test: 05073-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 PENTACHLOROPHENOL, TECHNICAL GRADE                            Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 13:53:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 4| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 3| 3| 2| 1| 7| 1| 3| 3| 3| 3| 3| 9| 8| 3| 2| 9| 2| 3| 1| 2| 2| 3| 3| 9| 3|             
                                           | 4| 1| 9| 0| 3| 8| 0| 0| 1| 0| 1| 5| 2| 0| 9| 4| 9| 0| 1| 9| 9| 1| 0| 5| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    200 PPM                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Distalis, Carcinoma             |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      C-Cell, Adenoma                      |                                                                   X      |             
      Follicular Cell, Adenoma             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              | +                                                                        |             
      Lymphoma Malignant Histiocytic       | X                                                                        |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granulosa Cell Tumor Malignant       |                      X                                                   |             
      Hemangiosarcoma                      |                                                                          |             
      Luteoma                              |                                                                   X      |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                        X                                 |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Polyp Stromal                        |                                           X                              |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                    +                     |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femoral, Hemangiosarcoma             |          X                                            X                  |             
      Femoral, Lymphoma Malignant          |                                                                          |             
          Histiocytic                      |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bronchial, Lymphoma Malignant        |                                                                          |             
          Histiocytic                      | X                                                                        |             
      Inguinal, Lymphoma Malignant Mixed   |                                                                          |             
      Lumbar, Lymphoma Malignant           |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Lumbar, Lymphoma Malignant Mixed     |                                                                          |             
      Mediastinal, Alveolar/Bronchiolar    |                                                                          |             
          Carcinoma, Metastatic, Lung      |                                              X                           |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Histiocytic                      | X                                                                        |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Lymphocytic                      |                                        X                                 |             
      Mediastinal, Lymphoma Malignant Mixed|                                              X                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  17                                                               
NTP Experiment-Test: 05073-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 PENTACHLOROPHENOL, TECHNICAL GRADE                            Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 13:53:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 4| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 3| 3| 2| 1| 7| 1| 3| 3| 3| 3| 3| 9| 8| 3| 2| 9| 2| 3| 1| 2| 2| 3| 3| 9| 3|             
                                           | 4| 1| 9| 0| 3| 8| 0| 0| 1| 0| 1| 5| 2| 0| 9| 4| 9| 0| 1| 9| 9| 1| 0| 5| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    200 PPM                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Mesenteric, Lymphoma Malignant       |                                                                          |             
          Histiocytic                      | X                                                                        |             
      Mesenteric, Lymphoma Malignant       |                                                                          |             
          Lymphocytic                      |                               X                                          |             
      Mesenteric, Lymphoma Malignant Mixed |                                              X                           |             
      Renal, Lymphoma Malignant Lymphocytic|                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                       X                  |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                               X        X                                 |             
      Lymphoma Malignant Mixed             |                                              X                           |             
                                            __________________________________________________________________________|             
   Spleen                                  | A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |          X        X                                   X                  |             
      Lymphoma Malignant Histiocytic       |                                           X                              |             
      Lymphoma Malignant Lymphocytic       |                                        X                                 |             
      Lymphoma Malignant Mixed             |                                              X                           |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  M  +  M  M  M  +  +  +  +  +  M  M  +  +  +  M  M  +  +  +  +  +  M  +|             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic, Lung                 |                                              X                           |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  +  M  M  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +|             
      Adenoacanthoma                       |                                                    X                     |             
      Adenocarcinoma                       |                                                                          |             
      Carcinoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Squamous Cell Carcinoma              |                X                                                         |             
      Subcutaneous Tissue, Fibrosarcoma    |                                     X                                    |             
      Subcutaneous Tissue, Hemangiosarcoma |          X                                                               |             
      Subcutaneous Tissue, Lymphoma        |                                                                          |             
          Malignant Histiocytic            |                                                                          |             
      Subcutaneous Tissue, Lymphoma        |                                                                          |             
          Malignant Lymphocytic            |                                                                          |             
      Subcutaneous Tissue, Lymphoma        |                                                                          |             
          Malignant Mixed                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lumbar, Vertebra, Osteosarcoma       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  18                                                               
NTP Experiment-Test: 05073-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 PENTACHLOROPHENOL, TECHNICAL GRADE                            Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 13:53:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 4| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 3| 3| 2| 1| 7| 1| 3| 3| 3| 3| 3| 9| 8| 3| 2| 9| 2| 3| 1| 2| 2| 3| 3| 9| 3|             
                                           | 4| 1| 9| 0| 3| 8| 0| 0| 1| 0| 1| 5| 2| 0| 9| 4| 9| 0| 1| 9| 9| 1| 0| 5| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    200 PPM                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
      Osteosarcoma, Metastatic, Bone       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoacanthoma, Metastatic, Mammary  |                                                                          |             
          Gland                            |                                                    X                     |             
      Alveolar/Bronchiolar Adenoma         |                                        X                                 |             
      Alveolar/Bronchiolar Carcinoma       |                                              X                           |             
      Fibrosarcoma, Metastatic, Skin       |                                                                          |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Mediastinum, Alveolar/Bronchiolar    |                                                                          |             
          Carcinoma, Metastatic, Lung      |                                              X                           |             
      Mediastinum, Lymphoma Malignant      |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Mediastinum, Lymphoma Malignant Mixed|                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |    X                                                                     |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                        X                                 |             
      Lymphoma Malignant Mixed             |                                              X                           |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | A  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       | X                                         X                              |             
      Lymphoma Malignant Lymphocytic       |                               X        X                                 |             
      Lymphoma Malignant Mixed             |                                              X                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  19                                                               
NTP Experiment-Test: 05073-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 PENTACHLOROPHENOL, TECHNICAL GRADE                            Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 13:53:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 4| 6| 2| 7| 6| 7| 7| 7| 7| 7| 7| 4| 3| 6| 7| 5| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 2| 2| 3| 7| 2| 2| 6| 3| 3| 2| 3| 3| 2| 1| 5| 8| 3| 4| 5| 3| 2| 2|            |
                                           | 1| 1| 1| 9| 9| 0| 5| 4| 9| 1| 0| 1| 9| 0| 0| 9| 3| 6| 1| 0| 7| 8| 1| 9| 9|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|     A      |
    200 PPM                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  A  A  +  +  +  A  +  +  +|  39        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  45        |
      Peyer's Patch, Lymphoma Malignant    |                                                                          |            |
          Mixed                            |                                                                      X   |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  A  +  +  +  +  M  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  A  +  +  +  +  M  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemangiosarcoma                      |       X                                                                  |          1 |
      Hemangiosarcoma, Multiple            |                                                                          |          3 |
      Hepatocellular Carcinoma             |                                                                          |          1 |
      Hepatocellular Adenoma               |    X                                X     X                              |          7 |
      Hepatocellular Adenoma, Multiple     |                                                                   X      |          1 |
      Lymphoma Malignant Histiocytic       |                X                                                         |          3 |
      Lymphoma Malignant Lymphocytic       |                      X        X  X                    X     X            |          5 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Lymphoma Malignant Lymphocytic       |                                     X                                    |          2 |
      Lymphoma Malignant Mixed             |                                                                         X|          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Lymphoma Malignant Lymphocytic       |                               X     X        X              X            |          5 |
      Lymphoma Malignant Mixed             |                                                          X              X|          2 |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  47        |
      Lymphoma Malignant Mixed             |                                                                         X|          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Lymphocytic       |                      X              X                                    |          2 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  20                                                               
NTP Experiment-Test: 05073-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 PENTACHLOROPHENOL, TECHNICAL GRADE                            Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 13:53:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 4| 6| 2| 7| 6| 7| 7| 7| 7| 7| 7| 4| 3| 6| 7| 5| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 2| 2| 3| 7| 2| 2| 6| 3| 3| 2| 3| 3| 2| 1| 5| 8| 3| 4| 5| 3| 2| 2|            |
                                           | 1| 1| 1| 9| 9| 0| 5| 4| 9| 1| 0| 1| 9| 0| 0| 9| 3| 6| 1| 0| 7| 8| 1| 9| 9|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|     A      |
    200 PPM                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Pheochromocytoma Benign              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  M  +  M  +  +  M  +  M  +  +  M  +  +  M  M  +  +  +  +  M  +  +  +|  35        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | M  M  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|  39        |
      Pars Distalis, Adenoma               |                                              X                          X|          5 |
      Pars Distalis, Carcinoma             |                                                       X                  |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Lymphoma Malignant Lymphocytic       |                                     X                                    |          1 |
      C-Cell, Adenoma                      |                                                                          |          1 |
      Follicular Cell, Adenoma             |                                                       X                  |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|  48        |
      Granulosa Cell Tumor Malignant       |                                                                          |          1 |
      Hemangiosarcoma                      |                               X                                          |          1 |
      Luteoma                              |                                                                          |          1 |
      Lymphoma Malignant Histiocytic       |                X                                                         |          1 |
      Lymphoma Malignant Lymphocytic       |                               X  X  X                       X            |          5 |
      Lymphoma Malignant Mixed             |    X                                                     X              X|          3 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Lymphoma Malignant Histiocytic       |                X                                                         |          1 |
      Lymphoma Malignant Lymphocytic       |                                     X                 X                  |          2 |
      Lymphoma Malignant Mixed             |                                                                         X|          1 |
      Polyp Stromal                        |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |             +                                                            |   2        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Femoral, Hemangiosarcoma             |                                                                          |          2 |
      Femoral, Lymphoma Malignant          |                                                                          |            |
          Histiocytic                      |                X           X                                             |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  M  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Bronchial, Lymphoma Malignant        |                                                                          |            |
          Histiocytic                      |                                                                          |          1 |
      Inguinal, Lymphoma Malignant Mixed   |                                                                         X|          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  21                                                               
NTP Experiment-Test: 05073-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 PENTACHLOROPHENOL, TECHNICAL GRADE                            Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 13:53:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 4| 6| 2| 7| 6| 7| 7| 7| 7| 7| 7| 4| 3| 6| 7| 5| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 2| 2| 3| 7| 2| 2| 6| 3| 3| 2| 3| 3| 2| 1| 5| 8| 3| 4| 5| 3| 2| 2|            |
                                           | 1| 1| 1| 9| 9| 0| 5| 4| 9| 1| 0| 1| 9| 0| 0| 9| 3| 6| 1| 0| 7| 8| 1| 9| 9|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|     A      |
    200 PPM                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Lumbar, Lymphoma Malignant           |                                                                          |            |
          Lymphocytic                      |                                                       X                  |          1 |
      Lumbar, Lymphoma Malignant Mixed     |                                                          X               |          1 |
      Mediastinal, Alveolar/Bronchiolar    |                                                                          |            |
          Carcinoma, Metastatic, Lung      |                                                                          |          1 |
      Mediastinal, Lymphoma Malignant      |                                                                          |            |
          Histiocytic                      |                            X                                             |          2 |
      Mediastinal, Lymphoma Malignant      |                                                                          |            |
          Lymphocytic                      |                               X                       X                  |          3 |
      Mediastinal, Lymphoma Malignant Mixed|                                                          X              X|          3 |
      Mesenteric, Lymphoma Malignant       |                                                                          |            |
          Histiocytic                      |                            X                                             |          2 |
      Mesenteric, Lymphoma Malignant       |                                                                          |            |
          Lymphocytic                      |                               X                       X     X            |          4 |
      Mesenteric, Lymphoma Malignant Mixed |                                                          X               |          2 |
      Renal, Lymphoma Malignant Lymphocytic|                                                       X                  |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  M  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
      Hemangiosarcoma                      |                                                                          |          1 |
      Lymphoma Malignant Histiocytic       |                            X                                             |          1 |
      Lymphoma Malignant Lymphocytic       |                               X  X  X        X        X     X            |          8 |
      Lymphoma Malignant Mixed             |    X                                                     X              X|          4 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Hemangiosarcoma                      |                                                                          |          3 |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                               X  X  X        X        X                  |          6 |
      Lymphoma Malignant Mixed             |    X                                                     X           X   |          4 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  M  M  +  +  M  +  M  +  +  +  +  +  M  +  +  +  M  M  +  +  +  +  +  +|  33        |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Metastatic, Lung                 |                                                                          |          1 |
      Lymphoma Malignant Histiocytic       |                            X                                             |          1 |
      Lymphoma Malignant Lymphocytic       |                                     X                                    |          1 |
      Lymphoma Malignant Mixed             |                                                          X               |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  M  +  +  +  M  +  M  +  +  M  +  M  +  M  +  +  +  +  +  +  +  M|  34        |
      Adenoacanthoma                       |                                                                          |          1 |
      Adenocarcinoma                       |       X                                                                  |          1 |
      Carcinoma                            |                                                    X                     |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  22                                                               
NTP Experiment-Test: 05073-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 PENTACHLOROPHENOL, TECHNICAL GRADE                            Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 13:53:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 4| 6| 2| 7| 6| 7| 7| 7| 7| 7| 7| 4| 3| 6| 7| 5| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 2| 2| 3| 7| 2| 2| 6| 3| 3| 2| 3| 3| 2| 1| 5| 8| 3| 4| 5| 3| 2| 2|            |
                                           | 1| 1| 1| 9| 9| 0| 5| 4| 9| 1| 0| 1| 9| 0| 0| 9| 3| 6| 1| 0| 7| 8| 1| 9| 9|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|     A      |
    200 PPM                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Squamous Cell Carcinoma              |                                                                          |          1 |
      Subcutaneous Tissue, Fibrosarcoma    |                                                                X         |          2 |
      Subcutaneous Tissue, Hemangiosarcoma |                                                                          |          1 |
      Subcutaneous Tissue, Lymphoma        |                                                                          |            |
          Malignant Histiocytic            |                X           X                                             |          2 |
      Subcutaneous Tissue, Lymphoma        |                                                                          |            |
          Malignant Lymphocytic            |                                     X                                    |          1 |
      Subcutaneous Tissue, Lymphoma        |                                                                          |            |
          Malignant Mixed                  |                                                                         X|          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Lumbar, Vertebra, Osteosarcoma       |                   X                                                      |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Lymphoma Malignant Lymphocytic       |                               X                             X            |          2 |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                   +                                                      |   1        |
      Osteosarcoma, Metastatic, Bone       |                   X                                                      |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenoacanthoma, Metastatic, Mammary  |                                                                          |            |
          Gland                            |                                                                          |          1 |
      Alveolar/Bronchiolar Adenoma         |                                  X                                       |          2 |
      Alveolar/Bronchiolar Carcinoma       |                                                                          |          1 |
      Fibrosarcoma, Metastatic, Skin       |                                                                X         |          1 |
      Lymphoma Malignant Histiocytic       |                X           X                                             |          2 |
      Lymphoma Malignant Lymphocytic       |                      X        X  X  X                                    |          4 |
      Lymphoma Malignant Mixed             |                                                          X               |          1 |
      Mediastinum, Alveolar/Bronchiolar    |                                                                          |            |
          Carcinoma, Metastatic, Lung      |                                                                          |          1 |
      Mediastinum, Lymphoma Malignant      |                                                                          |            |
          Lymphocytic                      |                      X                                                   |          1 |
      Mediastinum, Lymphoma Malignant Mixed|                                                                         X|          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Lymphoma Malignant Lymphocytic       |                                                             X            |          1 |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  23                                                               
NTP Experiment-Test: 05073-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 PENTACHLOROPHENOL, TECHNICAL GRADE                            Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 13:53:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 4| 6| 2| 7| 6| 7| 7| 7| 7| 7| 7| 4| 3| 6| 7| 5| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 2| 2| 3| 7| 2| 2| 6| 3| 3| 2| 3| 3| 2| 1| 5| 8| 3| 4| 5| 3| 2| 2|            |
                                           | 1| 1| 1| 9| 9| 0| 5| 4| 9| 1| 0| 1| 9| 0| 0| 9| 3| 6| 1| 0| 7| 8| 1| 9| 9|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|     A      |
    200 PPM                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Adenoma                              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Lymphoma Malignant Histiocytic       |                X           X                                             |          2 |
      Lymphoma Malignant Lymphocytic       |                               X  X  X        X        X     X            |          7 |
      Lymphoma Malignant Mixed             |                                                          X              X|          3 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Lymphoma Malignant Lymphocytic       |                               X     X        X        X                  |          4 |
      Lymphoma Malignant Mixed             |                                                          X              X|          2 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Histiocytic       |                X           X                                             |          4 |
      Lymphoma Malignant Lymphocytic       |                      X        X  X  X        X        X     X            |          9 |
      Lymphoma Malignant Mixed             |    X                                                     X           X  X|          5 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  24                                                               
NTP Experiment-Test: 05073-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 PENTACHLOROPHENOL, TECHNICAL GRADE                            Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 13:53:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 7| 4| 1| 7| 4| 1| 6| 4| 7| 7| 3| 5| 1| 5| 7| 2| 3| 4| 2| 3| 7|             
                             DAY ON TEST   | 3| 3| 2| 9| 2| 2| 8| 3| 2| 2| 7| 1| 3| 3| 3| 9| 0| 5| 3| 8| 6| 7| 6| 4| 3|             
                                           | 1| 1| 9| 8| 9| 7| 7| 1| 6| 6| 9| 7| 0| 0| 0| 8| 2| 2| 0| 6| 3| 5| 5| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    0 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  M  M  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  A  +  +  M  +  +  A  A  A  +  +  +  A  A  A  +  A  +  +  A  M  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  A  +  A  +  +  A  A  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  M  A  +  +  A  +  +  +  +  +  A  M  A  +  A  +  +  A  A  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  A  A  +  A  +  +  A  A  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  A  M  A  +  A  +  +  A  A  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  A  +  A  +  A  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  M  A  +  +  A  +  +  +  +  +  A  A  A  +  A  +  +  A  M  +|             
      Polyp Adenomatous                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  M  A  +  +  A  +  +  +  +  M  A  M  A  +  A  +  +  A  A  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  A  M  A  +  A  +  +  A  A  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  A  M  +|             
      Hepatocellular Carcinoma             |                                                                          |             
      Hepatocellular Carcinoma, Multiple   |          X                                                               |             
      Hepatocellular Adenoma               |    X                             X     X  X                              |             
      Lymphoma Malignant Mixed             |                                     X                                    |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                             +            |             
      Fibrosarcoma, Metastatic, Skin       |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  M  A  +  A  +  +  M  M  +|             
      Fibrosarcoma, Metastatic, Skin       |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  M  M  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  A  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  A  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  A  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                +         |             
      Peridontal Tissue, Sarcoma           |                                                                X         |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  M  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  A  +  +  +  +  +  M  +|             
      Capsule, Fibrosarcoma, Metastatic,   |                                                                          |             
           Skin                            |                                                                          |             
      Capsule, Sarcoma, Metastatic, Skin   |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  A  +  +  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  A  +  +  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  M  A  +  A  +  +  A  M  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  I  M  +  +  +  M  +  A  M  M  +  +  M  +  M  M  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  M  +  M  +  +  M  M  +|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  A  +  +  +  +  +  +  M  M  +|             
      Follicular Cell, Adenoma             |       X                                                                  |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  25                                                               
NTP Experiment-Test: 05073-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 PENTACHLOROPHENOL, TECHNICAL GRADE                            Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 13:53:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 7| 4| 1| 7| 4| 1| 6| 4| 7| 7| 3| 5| 1| 5| 7| 2| 3| 4| 2| 3| 7|             
                             DAY ON TEST   | 3| 3| 2| 9| 2| 2| 8| 3| 2| 2| 7| 1| 3| 3| 3| 9| 0| 5| 3| 8| 6| 7| 6| 4| 3|             
                                           | 1| 1| 9| 8| 9| 7| 7| 1| 6| 6| 9| 7| 0| 0| 0| 8| 2| 2| 0| 6| 3| 5| 5| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    0 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Penis                                   |                                                             +        +   |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |          +                    +           +                 +        +   |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                         +     +  +  +                 +                  |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  A  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  A  M  A  +  A  +  +  M  M  +|             
      Axillary, Inguinal, Fibrosarcoma,    |                                                                          |             
           Metastatic, Skin                |                                                                          |             
      Mesenteric, Lymphoma Malignant Mixed |                                     X                                    |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  A  M  A  +  A  +  +  M  M  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  M  A  +  +  +  +  A  M  +|             
      Lymphoma Malignant Mixed             |                                     X                                    |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  M  +  +  M  M  +  +  M  +  M  M  +  M  M  M  +  M  M  +  M  M  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +|             
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |             
      Subcutaneous Tissue, Fibrosarcoma,   |                                                                          |             
           Multiple                        |                                                                          |             
      Subcutaneous Tissue, Mast Cell Tumor |                                                                          |             
          Benign                           |                                                                          |             
      Subcutaneous Tissue, Sarcoma         |                                                    X                     |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  A  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  M  +|             
      Alveolar/Bronchiolar Adenoma         |                      X                                                  X|             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |          X                                                               |             
      Sarcoma, Metastatic, Skin            |                                                                          |             
      Sarcoma, Metastatic, Tooth           |                                                                X         |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  A  +  +  +  +  +  +  M  M  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  26                                                               
NTP Experiment-Test: 05073-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 PENTACHLOROPHENOL, TECHNICAL GRADE                            Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 13:53:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 7| 4| 1| 7| 4| 1| 6| 4| 7| 7| 3| 5| 1| 5| 7| 2| 3| 4| 2| 3| 7|             
                             DAY ON TEST   | 3| 3| 2| 9| 2| 2| 8| 3| 2| 2| 7| 1| 3| 3| 3| 9| 0| 5| 3| 8| 6| 7| 6| 4| 3|             
                                           | 1| 1| 9| 8| 9| 7| 7| 1| 6| 6| 9| 7| 0| 0| 0| 8| 2| 2| 0| 6| 3| 5| 5| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    0 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                 +                        |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  M  A  +|             
      Adenoma                              |                                                    X                     |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +|             
      Fibrosarcoma, Metastatic, Skin       |                                                                          |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                  +              +        +  +        +   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Hemangioma                           |                         X                                                |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                     X                                    |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  27                                                               
NTP Experiment-Test: 05073-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 PENTACHLOROPHENOL, TECHNICAL GRADE                            Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 13:53:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 7| 5| 4| 5| 6| 6| 7|                                            |            |
                             DAY ON TEST   | 4| 7| 3| 3| 4| 2| 1| 0| 7| 3|                                            |            |
                                           | 4| 8| 1| 1| 2| 7| 0| 4| 5| 1|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|                                            |     A      |
    0 PPM                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|                                            |     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  32        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  M  +  A  A  A  +  +                                             |  20        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +                                             |  29        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  A  A  +  +  +                                             |  24        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  M  +  +  +                                             |  27        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  A  M  +  +  +                                             |  25        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +                                             |  29        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  A  A  +  +  +                                             |  24        |
      Polyp Adenomatous                    |                         X                                                |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  A  M  +  +  +                                             |  23        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  A  +  +  +                                             |  26        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  32        |
      Hepatocellular Carcinoma             |    X                                                                     |          1 |
      Hepatocellular Carcinoma, Multiple   |                                                                          |          1 |
      Hepatocellular Adenoma               |                         X                                                |          5 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                         +                                                |   2        |
      Fibrosarcoma, Metastatic, Skin       |                         X                                                |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  A  +  +  +                                             |  27        |
      Fibrosarcoma, Metastatic, Skin       |                         X                                                |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  32        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +                                             |  31        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  31        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  31        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
      Peridontal Tissue, Sarcoma           |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  33        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  31        |
      Capsule, Fibrosarcoma, Metastatic,   |                                                                          |            |
           Skin                            |                         X                                                |          1 |
      Capsule, Sarcoma, Metastatic, Skin   |                      X                                                   |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +                                             |  31        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +                                             |  31        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  A  +  +  +                                             |  27        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  +  +  +  M  +  +  +  +                                             |  24        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  28                                                               
NTP Experiment-Test: 05073-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 PENTACHLOROPHENOL, TECHNICAL GRADE                            Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 13:53:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 7| 5| 4| 5| 6| 6| 7|                                            |            |
                             DAY ON TEST   | 4| 7| 3| 3| 4| 2| 1| 0| 7| 3|                                            |            |
                                           | 4| 8| 1| 1| 2| 7| 0| 4| 5| 1|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|                                            |     A      |
    0 PPM                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|                                            |     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  29        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  31        |
      Follicular Cell, Adenoma             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  34        |
                                            __________________________________________________________________________|____________|
   Penis                                   |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                   +                                                      |   6        |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +                                             |  34        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +           +                                                            |   7        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  34        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   | +                    +                                                   |   2        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | A  +  +  +  +  +  +  +  +  +                                             |  30        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  M  +  +  +  +  +  +  +  +                                             |  27        |
      Axillary, Inguinal, Fibrosarcoma,    |                                                                          |            |
           Metastatic, Skin                |          X                                                               |          1 |
      Mesenteric, Lymphoma Malignant Mixed |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  M  +  +  +  +  +  +  +  +                                             |  27        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  30        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  M  +  M  +     M  M  M  +                                             |  16        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M                                             |            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  33        |
      Subcutaneous Tissue, Fibrosarcoma    |                         X                                                |          1 |
      Subcutaneous Tissue, Fibrosarcoma,   |                                                                          |            |
           Multiple                        |          X                                                               |          1 |
      Subcutaneous Tissue, Mast Cell Tumor |                                                                          |            |
          Benign                           | X                                                                        |          1 |
      Subcutaneous Tissue, Sarcoma         |                      X                                                   |          2 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  35        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  29                                                               
NTP Experiment-Test: 05073-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 PENTACHLOROPHENOL, TECHNICAL GRADE                            Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 13:53:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 7| 5| 4| 5| 6| 6| 7|                                            |            |
                             DAY ON TEST   | 4| 7| 3| 3| 4| 2| 1| 0| 7| 3|                                            |            |
                                           | 4| 8| 1| 1| 2| 7| 0| 4| 5| 1|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|                                            |     A      |
    0 PPM                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|                                            |     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  A  +  +  +                                             |  31        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  33        |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          2 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                                          |          1 |
      Sarcoma, Metastatic, Skin            |                      X                                                   |          1 |
      Sarcoma, Metastatic, Tooth           |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  35        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  31        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                +                                                         |   2        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  M  +  +  +  +  +                                             |  29        |
      Adenoma                              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  33        |
      Fibrosarcoma, Metastatic, Skin       |                         X                                                |          1 |
                                            __________________________________________________________________________|____________|
   Urethra                                 |                   +                                                      |   6        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  34        |
      Hemangioma                           |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +                                             |  35        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  30                                                               
NTP Experiment-Test: 05073-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 PENTACHLOROPHENOL, TECHNICAL GRADE                            Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 13:53:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 6| 3| 5| 7| 7| 5| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 3| 5| 3|             
                             DAY ON TEST   | 3| 2| 2| 2| 5| 8| 3| 0| 5| 3| 3| 2| 0| 2| 6| 3| 3| 3| 3| 3| 3| 2| 1| 7| 4|             
                                           | 6| 9| 9| 8| 0| 7| 1| 5| 6| 0| 8| 9| 8| 9| 4| 0| 1| 1| 0| 1| 0| 1| 5| 7| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6|             
    100 PPM                                | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |          +  +  +        +     +                                +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             |          A  A  +        +     +                                A  A  +  A|             
                                            __________________________________________________________________________|             
   Intestine Large                         |          A  +  +        +     +                                +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |          A  A  +        +     +                                +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |          A  +  +        +     +                                +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |          A  A  M        +     +                                +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         |          A  A  +        +     +                                +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |          A  A  +        +     +                                +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |          A  A  +        +     +                                +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |          A  A  +        +     +                                +  A  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   |    +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Cholangiocarcinoma                   |                                           X                              |             
      Hemangiosarcoma                      |                                                                          |             
      Hemangiosarcoma, Multiple            |                                              X                           |             
      Hepatocellular Carcinoma             |       X              X           X  X              X           X         |             
      Hepatocellular Carcinoma, Multiple   |                                                                          |             
      Hepatocellular Adenoma               |       X        X           X           X  X        X                 X   |             
      Hepatocellular Adenoma, Multiple     |                   X                                   X                  |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |          A  +  +        +     +                                +  A  +  +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         |          A  +  +        +     +                                +  A  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 |          A  +  +        +     +                                +  A  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |          A  +  +        +     +                                +  A  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |          A  +  +        +     +                                +  A  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |          +  +  +        +     +     +                          +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |    +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Capsule, Adenoma                     |                   X                                                      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |    +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |    +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Pheochromocytoma Benign              |                      X              X  X                 X               |             
      Bilateral, Pheochromocytoma Benign   |                                  X                          X            |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |          A  +  +        +     +                                +  A  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |          A  +  +        +     +                                +  M  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |          M  +  +        +     +                                +  A  +  +|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |          A  +  +        +     +                                +  M  +  +|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  31                                                               
NTP Experiment-Test: 05073-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 PENTACHLOROPHENOL, TECHNICAL GRADE                            Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 13:53:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 6| 3| 5| 7| 7| 5| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 3| 5| 3|             
                             DAY ON TEST   | 3| 2| 2| 2| 5| 8| 3| 0| 5| 3| 3| 2| 0| 2| 6| 3| 3| 3| 3| 3| 3| 2| 1| 7| 4|             
                                           | 6| 9| 9| 8| 0| 7| 1| 5| 6| 0| 8| 9| 8| 9| 4| 0| 1| 1| 0| 1| 0| 1| 5| 7| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6|             
    100 PPM                                | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |          +  +  +  +     +     +                                +  A  +  +|             
                                            __________________________________________________________________________|             
   Penis                                   |             +                                                            |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |             +                                                        +   |             
      Carcinoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                |          A  +  +        +     +                                +  A  +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                                                                +  +     +|             
                                            __________________________________________________________________________|             
   Testes                                  |          +  +  +        +     +                                +  A  +  +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |          A  +  +        +     +                                +  A  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |          A  M  +  +     +  +  +     +           +              +  M  +  +|             
      Lumbar, Lymphoma Malignant           |                                                                          |             
          Histiocytic                      |                                                                          |             
      Mediastinal, Alveolar/Bronchiolar    |                                                                          |             
          Carcinoma, Metastatic, Lung      |                                                                          |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Histiocytic                      |                                                                          |             
      Mesenteric, Lymphoma Malignant       |                                                                          |             
          Histiocytic                      |                                                                          |             
      Mesenteric, Lymphoma Malignant Mixed |                                                                          |             
      Pancreatic, Lymphoma Malignant       |                                                                          |             
          Histiocytic                      |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |          A  M  +        +     +                                +  M  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  |       +  A  +  +        +  +  +              +                 +  M  +  +|             
                                            __________________________________________________________________________|             
   Thymus                                  |          M  +  +        M     M                                M  A  +  M|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |          M  M  M        M     M                                M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    |       +  A  +  +  +     +  +  +                          +  +  +  +  +  I|             
      Basosquamous Tumor Malignant         |                                                                          |             
      Carcinoma                            |                         X                                                |             
      Subcutaneous Tissue, Fibroma         |                                                          X               |             
      Subcutaneous Tissue, Fibrosarcoma    |       X           X        X  X                                X         |             
      Subcutaneous Tissue, Fibrosarcoma,   |                                                                          |             
           Multiple                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |          +  +  +     +  +  +  +           +  +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                         +                                                |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |          A  +  +        +     +                                +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  32                                                               
NTP Experiment-Test: 05073-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 PENTACHLOROPHENOL, TECHNICAL GRADE                            Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 13:53:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 6| 3| 5| 7| 7| 5| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 3| 5| 3|             
                             DAY ON TEST   | 3| 2| 2| 2| 5| 8| 3| 0| 5| 3| 3| 2| 0| 2| 6| 3| 3| 3| 3| 3| 3| 2| 1| 7| 4|             
                                           | 6| 9| 9| 8| 0| 7| 1| 5| 6| 0| 8| 9| 8| 9| 4| 0| 1| 1| 0| 1| 0| 1| 5| 7| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6|             
    100 PPM                                | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |          +  +  +        +     +                             +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                             X            |             
      Alveolar/Bronchiolar Carcinoma       |                                                                          |             
      Fibrosarcoma, Metastatic, Skin       |                               X                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |          +  +  +        +     +                                +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 |          +  +  +        +     +                                +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |          M  +  M        +     +                                +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |          A  +  +     +  +     +                                +  +  +  +|             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |          A  +  +        +     +                                +  A  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  33                                                               
NTP Experiment-Test: 05073-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 PENTACHLOROPHENOL, TECHNICAL GRADE                            Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 13:53:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 4| 7| 6| 7| 7| 7| 7| 6| 5| 7| 5| 7| 6| 7| 6| 3| 1| 7| 7| 7| 7| 6| 7|            |
                             DAY ON TEST   | 1| 8| 9| 0| 8| 3| 2| 2| 3| 2| 4| 3| 4| 3| 3| 3| 5| 3| 8| 3| 3| 2| 2| 9| 2|            |
                                           | 3| 9| 2| 4| 2| 1| 9| 9| 1| 6| 5| 0| 3| 1| 5| 1| 6| 6| 9| 1| 0| 9| 9| 3| 9|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9|     A      |
    100 PPM                                | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +     +                    +  +     +     +        +  +                  |  17        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +     A                    +  +     A     A        +  A                  |   8        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +     +                    +  +     +     +        +  +                  |  15        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +     +                    +  +     A     +        +  A                  |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +     +                    +  +     +     +        +  +                  |  15        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +     +                    +  +     +     +        +  A                  |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +     +                    +  +     A     +        +  +                  |  13        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +     +                    +  +     A     +        +  A                  |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +     +                    +  +     A     +        +  +                  |  13        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +     +                    +  +     A     +        +  +                  |  13        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Cholangiocarcinoma                   |                                                                          |          1 |
      Hemangiosarcoma                      |                      X                                                   |          1 |
      Hemangiosarcoma, Multiple            |                                                                          |          1 |
      Hepatocellular Carcinoma             |             X  X                                            X            |          9 |
      Hepatocellular Carcinoma, Multiple   |                                                 X                        |          1 |
      Hepatocellular Adenoma               | X                                      X     X           X           X   |         12 |
      Hepatocellular Adenoma, Multiple     |                X  X  X                          X              X  X      |          8 |
      Lymphoma Malignant Histiocytic       |                               X                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +     +                    +  +     +     +        +  +                  |  15        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +     +                    +  +     +     +        +  +                  |  15        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +     +                    +  +     A     +        +  +                  |  14        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +     +                    +  +     A     +        +  +                  |  14        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +     +                    +  +     A     +        +  +                  |  14        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +     +                    +  +     +     +        +  +                  |  18        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Capsule, Adenoma                     |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  I  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|  45        |
      Pheochromocytoma Benign              |                                                                          |          4 |
      Bilateral, Pheochromocytoma Benign   |             X  X                 X                          X            |          6 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +     +                    +  +     +     +        +  +                  |  15        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M     +                    +  +     +     M        +  +                  |  12        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +     I                    +  +     M     +        +  M                  |  12        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +     +                    +  +     +     +        +  +                  |  15        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  34                                                               
NTP Experiment-Test: 05073-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 PENTACHLOROPHENOL, TECHNICAL GRADE                            Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 13:53:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 4| 7| 6| 7| 7| 7| 7| 6| 5| 7| 5| 7| 6| 7| 6| 3| 1| 7| 7| 7| 7| 6| 7|            |
                             DAY ON TEST   | 1| 8| 9| 0| 8| 3| 2| 2| 3| 2| 4| 3| 4| 3| 3| 3| 5| 3| 8| 3| 3| 2| 2| 9| 2|            |
                                           | 3| 9| 2| 4| 2| 1| 9| 9| 1| 6| 5| 0| 3| 1| 5| 1| 6| 6| 9| 1| 0| 9| 9| 3| 9|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9|     A      |
    100 PPM                                | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +     +                    +  +     +     +        +  +                  |  17        |
                                            __________________________________________________________________________|____________|
   Penis                                   | +           +                                         +              +   |   5        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                   +                             +  +                 +   |   6        |
      Carcinoma                            |                   X                                                      |          1 |
                                            __________________________________________________________________________|____________|
   Prostate                                | +     +                    +  +     +     +        +  +                  |  15        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +                                                                        |   4        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +     +                    +  +     +     +        +  +  +               |  17        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                   +      |   1        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +     +                    +  +     +     +        +  +                  |  15        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +     +        +  +        +  +     +     +        +  +     +  +  +     +|  24        |
      Lumbar, Lymphoma Malignant           |                                                                          |            |
          Histiocytic                      |                               X                                          |          1 |
      Mediastinal, Alveolar/Bronchiolar    |                                                                          |            |
          Carcinoma, Metastatic, Lung      |                                     X                                    |          1 |
      Mediastinal, Lymphoma Malignant      |                                                                          |            |
          Histiocytic                      |                               X                                          |          1 |
      Mesenteric, Lymphoma Malignant       |                                                                          |            |
          Histiocytic                      |                               X                                          |          1 |
      Mesenteric, Lymphoma Malignant Mixed |                                                                X         |          1 |
      Pancreatic, Lymphoma Malignant       |                                                                          |            |
          Histiocytic                      |                               X                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +     +                    +  +           +           +                  |  12        |
      Lymphoma Malignant Histiocytic       |                               X                                          |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +              +  +     +     +  +     +  +           +      |  23        |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +     M                    I  +     M     I        +  +                  |   7        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M     M                    M  M     M     M        M  M                  |            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +                 +  +     +     +  +  +  +  +  +        +  +   |  27        |
      Basosquamous Tumor Malignant         |                                           X                              |          1 |
      Carcinoma                            |                                                                          |          1 |
      Subcutaneous Tissue, Fibroma         |                                                                      X   |          2 |
      Subcutaneous Tissue, Fibrosarcoma    |          X                 X                             X        X      |          9 |
      Subcutaneous Tissue, Fibrosarcoma,   |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  35                                                               
NTP Experiment-Test: 05073-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 PENTACHLOROPHENOL, TECHNICAL GRADE                            Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 13:53:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 4| 7| 6| 7| 7| 7| 7| 6| 5| 7| 5| 7| 6| 7| 6| 3| 1| 7| 7| 7| 7| 6| 7|            |
                             DAY ON TEST   | 1| 8| 9| 0| 8| 3| 2| 2| 3| 2| 4| 3| 4| 3| 3| 3| 5| 3| 8| 3| 3| 2| 2| 9| 2|            |
                                           | 3| 9| 2| 4| 2| 1| 9| 9| 1| 6| 5| 0| 3| 1| 5| 1| 6| 6| 9| 1| 0| 9| 9| 3| 9|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9|     A      |
    100 PPM                                | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
           Multiple                        |    X                                                                     |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +     +  +     +  I  +     +  +     +     +        +  +                  |  28        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +     +                    +  +     +     +        +  +                  |  16        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +     +                    +  +     +     +        +  +                  |  18        |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          1 |
      Alveolar/Bronchiolar Carcinoma       |                                     X                                    |          1 |
      Fibrosarcoma, Metastatic, Skin       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +     +                    +  +     +     +        +  +                  |  17        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +     +                    +  +     +     +        +  +                  |  17        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +     +                    +  +     +     +        M  M                  |  12        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +     +                    +  +     +     +  +     +  +                  |  18        |
                                            __________________________________________________________________________|____________|
   Urethra                                 | +                                                     +                  |   2        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +     +                    +  +     +     +        +  A              +   |  15        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Lymphoma Malignant Histiocytic       |                               X                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                X         |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  36                                                               
NTP Experiment-Test: 05073-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 PENTACHLOROPHENOL, TECHNICAL GRADE                            Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 13:53:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 7| 5| 4| 6| 7| 5| 5| 7| 1| 7| 5| 3| 2| 3| 3| 3| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 1| 2| 8| 9| 2| 2| 9| 5| 0| 8| 8| 3| 4| 3| 7| 7| 9| 7| 7| 7| 4| 3| 3| 3| 2|             
                                           | 0| 9| 0| 0| 9| 8| 0| 6| 1| 2| 4| 1| 2| 0| 0| 6| 9| 6| 6| 6| 5| 0| 1| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|             
    200 PPM                                | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | M  +  A  A  +  M  A  A  +  A  A  +  +  +  A  +  A  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |    X                                                                     |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  A  +  A  A  M  +  M  A  +  +  M  A  +  M  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  A  +  A  +  +  A  +  +  +  A  +  A  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | M  +  +  A  +  M  A  A  +  A  A  +  +  +  M  +  M  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  A  +  +  A  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  A  +  A  A  M  +  M  +  +  M  +  +  +  A  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  A  +  A  A  M  +  A  A  +  +  +  A  +  M  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  A  +  A  A  M  +  A  A  +  +  +  A  +  A  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangioma                           |                               X                                          |             
      Hemangiosarcoma                      |                                                                          |             
      Hepatocellular Carcinoma             | X           X  X                          X                              |             
      Hepatocellular Carcinoma, Multiple   |                                                                          |             
      Hepatocellular Adenoma               |       X  X           X  X  X                 X     X  X     X           X|             
      Hepatocellular Adenoma, Multiple     | X  X        X     X           X  X     X                       X  X      |             
      Hepatocholangiocarcinoma             |       X                                                                  |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |    X                                                                     |             
      Sarcoma, Metastatic, Skin            |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |       +                                      +                           |             
      Hepatocholangiocarcinoma, Metastatic,|                                                                          |             
           Liver                           |       X                                                                  |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  M  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Squamous Cell Papilloma              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   |                                  +     +                                 |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocholangiocarcinoma, Metastatic,|                                                                          |             
           Liver                           |       X                                                                  |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  A  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pheochromocytoma Benign              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  37                                                               
NTP Experiment-Test: 05073-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 PENTACHLOROPHENOL, TECHNICAL GRADE                            Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 13:53:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 7| 5| 4| 6| 7| 5| 5| 7| 1| 7| 5| 3| 2| 3| 3| 3| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 1| 2| 8| 9| 2| 2| 9| 5| 0| 8| 8| 3| 4| 3| 7| 7| 9| 7| 7| 7| 4| 3| 3| 3| 2|             
                                           | 0| 9| 0| 0| 9| 8| 0| 6| 1| 2| 4| 1| 2| 0| 0| 6| 9| 6| 6| 6| 5| 0| 1| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|             
    200 PPM                                | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Bilateral, Pheochromocytoma Benign   | X  X        X           X        X     X                       X  X  X   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  M  M  +  +  +  M  +  +  +  +  M  M  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  M  +  +  A  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Follicular Cell, Adenoma             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Penis                                   |                                                 M                        |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +                                            +        +  +               |             
      Carcinoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                   +              +        +     +                        |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Axillary, Lymphoma Malignant         |                                                                          |             
          Histiocytic                      |                                                                          |             
      Inguinal, Lymphoma Malignant         |                                                                          |             
          Histiocytic                      |                                                                          |             
      Inguinal, Sarcoma, Metastatic, Skin  |                                                                          |             
      Lumbar, Lymphoma Malignant           |                                                                          |             
          Histiocytic                      |                                                                          |             
      Mediastinal, Lymphoma Malignant Mixed|    X                                                                     |             
      Mesenteric, Lymphoma Malignant       |                                                                          |             
          Histiocytic                      |                                                                          |             
      Mesenteric, Lymphoma Malignant       |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Mesenteric, Lymphoma Malignant Mixed |    X                                                                     |             
      Renal, Lymphoma Malignant Histiocytic|                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |    X                                                                     |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangioma                           | X                                                                        |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |    X                                                                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  38                                                               
NTP Experiment-Test: 05073-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 PENTACHLOROPHENOL, TECHNICAL GRADE                            Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 13:53:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 7| 5| 4| 6| 7| 5| 5| 7| 1| 7| 5| 3| 2| 3| 3| 3| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 1| 2| 8| 9| 2| 2| 9| 5| 0| 8| 8| 3| 4| 3| 7| 7| 9| 7| 7| 7| 4| 3| 3| 3| 2|             
                                           | 0| 9| 0| 0| 9| 8| 0| 6| 1| 2| 4| 1| 2| 0| 0| 6| 9| 6| 6| 6| 5| 0| 1| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|             
    200 PPM                                | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  M  M  +  M  M  M  M  M  M  M  M  M  M  +  M  +  +  +  M  +  +  M  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Squamous Cell Carcinoma              |                                                                          |             
      Subcutaneous Tissue, Fibroma         |    X                                                                     |             
      Subcutaneous Tissue, Fibrosarcoma    |                         X                                                |             
      Subcutaneous Tissue,                 |                                                                          |             
          Hepatocholangiocarcinoma,        |                                                                          |             
          Metastatic, Liver                |       X                                                                  |             
      Subcutaneous Tissue, Sarcoma         |                                                             X        X  X|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                                X  X      |             
      Alveolar/Bronchiolar Adenoma,        |                                                                          |             
          Multiple                         |                                                                         X|             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
      Lymphoma Malignant Mixed             |    X                                                                     |             
      Sarcoma, Metastatic, Skin            |                                                             X            |             
      Mediastinum,                         |                                                                          |             
          Hepatocholangiocarcinoma,        |                                                                          |             
          Metastatic, Liver                |       X                                                                  |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     | +                                                                        |             
                                            __________________________________________________________________________|             
   Eye                                     |                                        +                                 |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  M  +  +  +  +|             
      Adenoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocholangiocarcinoma, Metastatic,|                                                                          |             
           Liver                           |       X                                                                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  39                                                               
NTP Experiment-Test: 05073-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 PENTACHLOROPHENOL, TECHNICAL GRADE                            Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 13:53:04  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 7| 5| 4| 6| 7| 5| 5| 7| 1| 7| 5| 3| 2| 3| 3| 3| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 1| 2| 8| 9| 2| 2| 9| 5| 0| 8| 8| 3| 4| 3| 7| 7| 9| 7| 7| 7| 4| 3| 3| 3| 2|             
                                           | 0| 9| 0| 0| 9| 8| 0| 6| 1| 2| 4| 1| 2| 0| 0| 6| 9| 6| 6| 6| 5| 0| 1| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|             
    200 PPM                                | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Lymphoma Malignant Mixed             |    X                                                                     |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |    X                                                                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  40                                                               
NTP Experiment-Test: 05073-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 PENTACHLOROPHENOL, TECHNICAL GRADE                            Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 13:53:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 5| 7| 5| 7| 4| 6| 7| 5| 7| 7| 7| 6| 4| 6| 6| 7| 7| 6| 7| 7|            |
                             DAY ON TEST   | 3| 3| 4| 2| 3| 4| 3| 9| 3| 4| 9| 3| 1| 2| 3| 2| 5| 7| 4| 1| 3| 2| 3| 2| 3|            |
                                           | 0| 0| 0| 9| 1| 9| 0| 8| 1| 6| 0| 1| 2| 9| 0| 9| 4| 6| 4| 9| 1| 9| 6| 9| 0|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5|     A      |
    200 PPM                                | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +     +  +|  48        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  A  +  A  A  +  A  +  +  +  A  A  +  A  +  +     +  +|  32        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  A  +  +     +  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  A  +  +  M  +  A  +  +  +  +  A  +  A  +  +     +  +|  35        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  A  +  +     +  +|  41        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  A  +  +  M  +  M  +  +  +  +  A  +  A  +  +     +  +|  35        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  A  +  +     +  +|  43        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  A  +  A  +  +     +  +|  38        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  A  +  +  +  +  M  +  +  +  +  A  +  A  +  +     +  +|  37        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  A  +  A  +  +     +  +|  37        |
      Lymphoma Malignant Mixed             |       X                                                                  |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +     +  +|  48        |
      Hemangioma                           |                                                                          |          1 |
      Hemangiosarcoma                      |                                                             X            |          1 |
      Hepatocellular Carcinoma             | X  X           X        X           X  X        X                        |         11 |
      Hepatocellular Carcinoma, Multiple   |             X                                                            |          1 |
      Hepatocellular Adenoma               |          X           X                 X        X  X                     |         15 |
      Hepatocellular Adenoma, Multiple     | X  X        X     X     X        X                             X     X  X|         18 |
      Hepatocholangiocarcinoma             |                                                                          |          1 |
      Lymphoma Malignant Histiocytic       |                               X                                          |          1 |
      Lymphoma Malignant Mixed             |       X                                                                  |          2 |
      Sarcoma, Metastatic, Skin            |                            X                                             |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   2        |
      Hepatocholangiocarcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  A  +  +     +  +|  44        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +     +  +|  48        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  A  +  +     +  +|  44        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  A  +  +     +  +|  43        |
      Squamous Cell Papilloma              |          X                                                               |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  A  +  +     +  +|  42        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |       +                                                                  |   3        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +|  49        |
      Hepatocholangiocarcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  41                                                               
NTP Experiment-Test: 05073-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 PENTACHLOROPHENOL, TECHNICAL GRADE                            Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 13:53:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 5| 7| 5| 7| 4| 6| 7| 5| 7| 7| 7| 6| 4| 6| 6| 7| 7| 6| 7| 7|            |
                             DAY ON TEST   | 3| 3| 4| 2| 3| 4| 3| 9| 3| 4| 9| 3| 1| 2| 3| 2| 5| 7| 4| 1| 3| 2| 3| 2| 3|            |
                                           | 0| 0| 0| 9| 1| 9| 0| 8| 1| 6| 0| 1| 2| 9| 0| 9| 4| 6| 4| 9| 1| 9| 6| 9| 0|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5|     A      |
    200 PPM                                | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +     +  +|  46        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +     +  +|  46        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +     +  +|  45        |
      Pheochromocytoma Benign              |          X     X                          X                          X   |          4 |
      Bilateral, Pheochromocytoma Benign   | X  X        X     X     X        X     X     X  X     X                  |         19 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  A  +  +     +  +|  44        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +     +  +|  42        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  M  +  +  +  +  A  +  +  M  +  +  +  +  +  +  +  +  M  +  +     +  +|  41        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +     +  +|  47        |
      Follicular Cell, Adenoma             |    X                                                                     |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                        +                                 |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +     +  +|  47        |
                                            __________________________________________________________________________|____________|
   Penis                                   |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +                       +        +                    +                  |   8        |
      Carcinoma                            | X                                                                        |          1 |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +     +  +|  45        |
      Lymphoma Malignant Mixed             |       X                                                                  |          1 |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |       +                                            +  +                  |   7        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +     +  +|  47        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  A  +  M     +  +|  44        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  M  +  +     +  +|  44        |
      Axillary, Lymphoma Malignant         |                                                                          |            |
          Histiocytic                      |                                  X                                       |          1 |
      Inguinal, Lymphoma Malignant         |                                                                          |            |
          Histiocytic                      |                                  X                                       |          1 |
      Inguinal, Sarcoma, Metastatic, Skin  |                            X                                             |          1 |
      Lumbar, Lymphoma Malignant           |                                                                          |            |
          Histiocytic                      |                                  X                                       |          1 |
      Mediastinal, Lymphoma Malignant Mixed|                                                                          |          1 |
      Mesenteric, Lymphoma Malignant       |                                                                          |            |
          Histiocytic                      |                                  X                                       |          1 |
      Mesenteric, Lymphoma Malignant       |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  42                                                               
NTP Experiment-Test: 05073-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 PENTACHLOROPHENOL, TECHNICAL GRADE                            Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 13:53:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 5| 7| 5| 7| 4| 6| 7| 5| 7| 7| 7| 6| 4| 6| 6| 7| 7| 6| 7| 7|            |
                             DAY ON TEST   | 3| 3| 4| 2| 3| 4| 3| 9| 3| 4| 9| 3| 1| 2| 3| 2| 5| 7| 4| 1| 3| 2| 3| 2| 3|            |
                                           | 0| 0| 0| 9| 1| 9| 0| 8| 1| 6| 0| 1| 2| 9| 0| 9| 4| 6| 4| 9| 1| 9| 6| 9| 0|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5|     A      |
    200 PPM                                | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
          Lymphocytic                      |                   X                                                      |          1 |
      Mesenteric, Lymphoma Malignant Mixed |       X                                                                  |          2 |
      Renal, Lymphoma Malignant Histiocytic|                                  X                                       |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  M  +  +     +  +|  43        |
      Lymphoma Malignant Histiocytic       |                                  X                                       |          1 |
      Lymphoma Malignant Mixed             |       X                                                                  |          2 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +     +  +|  46        |
      Hemangioma                           |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                        X                                 |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  M  +  M  M  M  M  +  M  +  M  +  M  M  M  M  M  M  M  +  +     M  +|  18        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M     M  M|            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +|  49        |
      Squamous Cell Carcinoma              |                         X                                                |          1 |
      Subcutaneous Tissue, Fibroma         |    X                                            X                        |          3 |
      Subcutaneous Tissue, Fibrosarcoma    |                                                                      X  X|          3 |
      Subcutaneous Tissue,                 |                                                                          |            |
          Hepatocholangiocarcinoma,        |                                                                          |            |
          Metastatic, Liver                |                                                                          |          1 |
      Subcutaneous Tissue, Sarcoma         |                            X                                             |          4 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M     +  +|  48        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +     +  +|  48        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +|  49        |
      Alveolar/Bronchiolar Adenoma         |    X                    X                    X                           |          5 |
      Alveolar/Bronchiolar Adenoma,        |                                                                          |            |
          Multiple                         |                                                                          |          1 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |             X                                                            |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Sarcoma, Metastatic, Skin            |                            X                                             |          2 |
      Mediastinum,                         |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  43                                                               
NTP Experiment-Test: 05073-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                 PENTACHLOROPHENOL, TECHNICAL GRADE                            Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 13:53:04  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 5| 7| 5| 7| 4| 6| 7| 5| 7| 7| 7| 6| 4| 6| 6| 7| 7| 6| 7| 7|            |
                             DAY ON TEST   | 3| 3| 4| 2| 3| 4| 3| 9| 3| 4| 9| 3| 1| 2| 3| 2| 5| 7| 4| 1| 3| 2| 3| 2| 3|            |
                                           | 0| 0| 0| 9| 1| 9| 0| 8| 1| 6| 0| 1| 2| 9| 0| 9| 4| 6| 4| 9| 1| 9| 6| 9| 0|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5|     A      |
    200 PPM                                | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
          Hepatocholangiocarcinoma,        |                                                                          |            |
          Metastatic, Liver                |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +|  49        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +     +  +|  48        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  M  +     +  +|  43        |
      Adenoma                              |             X           X                                                |          2 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +     +  +|  47        |
      Hepatocholangiocarcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                                          |          1 |
      Lymphoma Malignant Mixed             |       X                                                                  |          2 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  A  +  +     +  +|  43        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +|  49        |
      Lymphoma Malignant Histiocytic       |                               X  X                                       |          2 |
      Lymphoma Malignant Lymphocytic       |                   X                    X                                 |          2 |
      Lymphoma Malignant Mixed             |       X                                                                  |          2 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  44                                                               
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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.