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TR 349 Mouse Pathology Tables


                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                 TECHNICAL GRADE PENTACHLOROPHENOL


NTP Experiment-Test: 05073-01                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/09/94
Route: DOSED FEED                                                                                                 Time: 05:28:16




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  87-86-5

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05073-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                 TECHNICAL GRADE PENTACHLOROPHENOL                             Date: 09/09/94  
Route: DOSED FEED                                                                                                 Time: 05:28:16  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 PPM        100 PPM      200 PPM                                                
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          35           50           50                                                  
  Early Deaths                                                                                                                      
    Natural Death                                      6            8           13                                                  
    Moribund Sacrifice                                              1            5                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                28           41           30                                                  
    Natural Death                                      1                         2                                                  
  Animals Examined Microscopically                    35           50           50                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (30)         (2)          (45)                                                
   Intestine Small, Ileum                             (31)         (1)          (45)                                                
   Intestine Small, Jejunum                           (32)         (5)          (46)                                                
   Liver                                              (33)         (49)         (50)                                                
      Fibrosarcoma, Metastatic                                      1 (2%)                                                          
      Hemangiosarcoma                                                            1 (2%)                                             
      Hemangiosarcoma, Multiple                                     2 (4%)       3 (6%)                                             
      Hepatocellular Carcinoma                                      1 (2%)       1 (2%)                                             
      Hepatocellular Adenoma                           3 (9%)       7 (14%)      7 (14%)                                            
      Hepatocellular Adenoma, Multiple                              1 (2%)       1 (2%)                                             
      Ito Cell Tumor Benign, Multiple                               1 (2%)                                                          
      Sarcoma, Metastatic, Uncertain Primary Site      1 (3%)                                                                       
   Mesentery                                          (3)          (1)                                                              
      Fibrosarcoma, Metastatic                                      1 (100%)                                                        
      Sarcoma, Metastatic, Uncertain Primary Site      1 (33%)                                                                      
   Pancreas                                           (31)         (4)          (48)                                                
      Sarcoma, Metastatic, Uncertain Primary Site      1 (3%)                                                                       
   Salivary Glands                                    (33)         (4)          (47)                                                
   Stomach, Forestomach                               (32)         (3)          (46)                                                
      Squamous Cell Papilloma                          4 (13%)                                                                      
      Squamous Cell Papilloma, Multiple                1 (3%)                                                                       
   Stomach, Glandular                                 (32)         (3)          (47)                                                
      Sarcoma, Metastatic, Uncertain Primary Site      1 (3%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (35)         (4)          (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   2                                                               
NTP Experiment-Test: 05073-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                 TECHNICAL GRADE PENTACHLOROPHENOL                             Date: 09/09/94  
Route: DOSED FEED                                                                                                 Time: 05:28:16  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 PPM        100 PPM      200 PPM                                                
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (33)         (48)         (49)                                                
      Adenoma                                          1 (3%)                                                                       
      Sarcoma, Metastatic, Uncertain Primary Site      1 (3%)                                                                       
   Adrenal Gland, Medulla                             (33)         (48)         (49)                                                
      Pheochromocytoma Malignant                       2 (6%)                                                                       
      Pheochromocytoma Benign                                       1 (2%)       1 (2%)                                             
      Bilateral, Pheochromocytoma Benign                            1 (2%)                                                          
   Pituitary Gland                                    (32)         (14)         (39)                                                
      Pars Distalis, Adenoma                          11 (34%)      8 (57%)      5 (13%)                                            
      Pars Distalis, Carcinoma                                                   1 (3%)                                             
   Thyroid Gland                                      (33)         (4)          (48)                                                
      C-Cell, Adenoma                                                            1 (2%)                                             
      Follicular Cell, Adenoma                                                   1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                                                   (1)                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (30)         (23)         (48)                                                
      Adenoma                                          2 (7%)       1 (4%)                                                          
      Carcinoma                                                     1 (4%)                                                          
      Granulosa Cell Tumor Malignant                                             1 (2%)                                             
      Hemangiosarcoma                                                            1 (2%)                                             
      Luteoma                                          1 (3%)       2 (9%)       1 (2%)                                             
   Uterus                                             (33)         (37)         (48)                                                
      Polyp Stromal                                                 1 (3%)       1 (2%)                                             
      Sarcoma, Metastatic, Uncertain Primary Site      1 (3%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (35)         (4)          (49)                                                
      Femoral, Hemangiosarcoma                                                   2 (4%)                                             
   Lymph Node                                         (33)         (12)         (46)                                                
      Mediastinal, Alveolar/Bronchiolar Carcinoma,                                                                                  
           Metastatic, Lung                                                      1 (2%)                                             
      Mediastinal, Sarcoma, Metastatic, Uncertain                                                                                   
          Primary Site                                 1 (3%)                                                                       
   Lymph Node, Mandibular                             (33)         (4)          (45)                                                
      Hemangiosarcoma                                                            1 (2%)                                             
   Spleen                                             (33)         (13)         (47)                                                
      Fibrosarcoma                                                  1 (8%)                                                          
                                                             Page   3                                                               
NTP Experiment-Test: 05073-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                 TECHNICAL GRADE PENTACHLOROPHENOL                             Date: 09/09/94  
Route: DOSED FEED                                                                                                 Time: 05:28:16  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 PPM        100 PPM      200 PPM                                                
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
      Hemangiosarcoma                                               1 (8%)       3 (6%)                                             
      Sarcoma, Metastatic, Uncertain Primary Site      1 (3%)                                                                       
   Thymus                                             (28)         (2)          (33)                                                
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                  1 (3%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (30)         (3)          (34)                                                
      Adenoacanthoma                                                             1 (3%)                                             
      Adenocarcinoma                                   3 (10%)      2 (67%)      1 (3%)                                             
      Carcinoma                                                                  1 (3%)                                             
   Skin                                               (33)         (5)          (48)                                                
      Squamous Cell Carcinoma                                                    1 (2%)                                             
      Subcutaneous Tissue, Fibrosarcoma                             1 (20%)      2 (4%)                                             
      Subcutaneous Tissue, Hemangiosarcoma                                       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (35)         (4)          (49)                                                
      Lumbar, Vertebra, Osteosarcoma                                             1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (33)         (4)          (49)                                                
   Spinal Cord                                                                  (1)                                                 
      Osteosarcoma, Metastatic, Bone                                             1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (35)         (5)          (50)                                                
      Adenoacanthoma, Metastatic, Mammary Gland                                  1 (2%)                                             
      Alveolar/Bronchiolar Adenoma                                  1 (20%)      2 (4%)                                             
      Alveolar/Bronchiolar Carcinoma                   1 (3%)                    1 (2%)                                             
      Fibrosarcoma, Metastatic, Skin                                             1 (2%)                                             
      Sarcoma, Metastatic, Uncertain Primary Site      1 (3%)                                                                       
      Mediastinum, Alveolar/Bronchiolar Carcinoma,                                                                                  
           Metastatic, Lung                                                      1 (2%)                                             
   Nose                                               (35)         (4)          (49)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   4                                                               
NTP Experiment-Test: 05073-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                 TECHNICAL GRADE PENTACHLOROPHENOL                             Date: 09/09/94  
Route: DOSED FEED                                                                                                 Time: 05:28:16  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 PPM        100 PPM      200 PPM                                                
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (32)         (4)          (49)                                                
      Adenoma                                          2 (6%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (33)         (7)          (49)                                                
      Sarcoma, Metastatic, Uncertain Primary Site      1 (3%)                                                                       
   Urinary Bladder                                    (32)         (3)          (47)                                                
      Sarcoma, Metastatic, Uncertain Primary Site      1 (3%)                                                                       
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(35)        *(50)        *(50)                                                
      Lymphoma Malignant Histiocytic                   1 (3%)       1 (2%)       4 (8%)                                             
      Lymphoma Malignant Lymphocytic                  12 (34%)      6 (12%)      9 (18%)                                            
      Lymphoma Malignant Mixed                         1 (3%)       2 (4%)       5 (10%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   5                                                               
NTP Experiment-Test: 05073-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                 TECHNICAL GRADE PENTACHLOROPHENOL                             Date: 09/09/94  
Route: DOSED FEED                                                                                                 Time: 05:28:16  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 PPM        100 PPM      200 PPM                                                
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            27          30          37                                                   
     Total Primary Neoplasms                           45          42          62                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 17          17          19                                                   
     Total Benign Neoplasms                            25          24          21                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              18          17          30                                                   
     Total Malignant Neoplasms                         20          18          41                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              1           1           4                                                   
     Total Metastatic Neoplasm                         11           2           6                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms               1                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   6                                                               
NTP Experiment-Test: 05073-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                 TECHNICAL GRADE PENTACHLOROPHENOL                             Date: 09/09/94  
Route: DOSED FEED                                                                                                 Time: 05:28:16  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 PPM        100 PPM      200 PPM                                                
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          35           50           50                                                  
  Early Deaths                                                                                                                      
    Natural Death                                     18           14           21                                                  
    Moribund Sacrifice                                 5           12            3                                                  
    Drowned                                                                      4                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                12           24           22                                                  
  Animals Examined Microscopically                    35           49           49                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (20)         (8)          (32)                                                
   Intestine Small, Duodenum                          (24)         (12)         (38)                                                
      Polyp Adenomatous                                1 (4%)                                                                       
   Intestine Small, Jejunum                           (26)         (13)         (37)                                                
   Liver                                              (32)         (47)         (48)                                                
      Cholangiocarcinoma                                            1 (2%)                                                          
      Hemangioma                                                                 1 (2%)                                             
      Hemangiosarcoma                                               1 (2%)       1 (2%)                                             
      Hemangiosarcoma, Multiple                                     1 (2%)                                                          
      Hepatocellular Carcinoma                         1 (3%)       9 (19%)     11 (23%)                                            
      Hepatocellular Carcinoma, Multiple               1 (3%)       1 (2%)       1 (2%)                                             
      Hepatocellular Adenoma                           5 (16%)     12 (26%)     15 (31%)                                            
      Hepatocellular Adenoma, Multiple                              8 (17%)     18 (38%)                                            
      Hepatocholangiocarcinoma                                                   1 (2%)                                             
      Sarcoma, Metastatic, Skin                                                  1 (2%)                                             
   Mesentery                                          (2)                       (2)                                                 
      Fibrosarcoma, Metastatic, Skin                   1 (50%)                                                                      
      Hepatocholangiocarcinoma, Metastatic, Liver                                1 (50%)                                            
   Pancreas                                           (27)         (15)         (44)                                                
      Fibrosarcoma, Metastatic, Skin                   1 (4%)                                                                       
   Stomach, Forestomach                               (31)         (14)         (43)                                                
      Squamous Cell Papilloma                                                    1 (2%)                                             
   Tooth                                              (1)                       (3)                                                 
      Peridontal Tissue, Sarcoma                       1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (33)         (18)         (49)                                                
      Hepatocholangiocarcinoma, Metastatic, Liver                                1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   7                                                               
NTP Experiment-Test: 05073-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                 TECHNICAL GRADE PENTACHLOROPHENOL                             Date: 09/09/94  
Route: DOSED FEED                                                                                                 Time: 05:28:16  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 PPM        100 PPM      200 PPM                                                
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (31)         (47)         (46)                                                
      Capsule, Adenoma                                              1 (2%)                                                          
      Capsule, Fibrosarcoma, Metastatic, Skin          1 (3%)                                                                       
      Capsule, Sarcoma, Metastatic, Skin               1 (3%)                                                                       
   Adrenal Gland, Medulla                             (31)         (45)         (45)                                                
      Pheochromocytoma Benign                                       4 (9%)       4 (9%)                                             
      Bilateral, Pheochromocytoma Benign                            6 (13%)     19 (42%)                                            
   Thyroid Gland                                      (31)         (15)         (47)                                                
      Follicular Cell, Adenoma                         1 (3%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Preputial Gland                                    (6)          (6)          (8)                                                 
      Carcinoma                                                     1 (17%)      1 (13%)                                            
   Prostate                                           (34)         (15)         (45)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node                                         (27)         (24)         (44)                                                
      Axillary, Inguinal, Fibrosarcoma, Metastatic,                                                                                 
           Skin                                        1 (4%)                                                                       
      Inguinal, Sarcoma, Metastatic, Skin                                        1 (2%)                                             
      Mediastinal, Alveolar/Bronchiolar Carcinoma,                                                                                  
           Metastatic, Lung                                         1 (4%)                                                          
   Lymph Node, Mandibular                             (27)         (12)         (43)                                                
   Spleen                                             (30)         (23)         (46)                                                
      Hemangioma                                                                 1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (33)         (27)         (49)                                                
      Basosquamous Tumor Malignant                                  1 (4%)                                                          
      Carcinoma                                                     1 (4%)                                                          
      Squamous Cell Carcinoma                                                    1 (2%)                                             
      Subcutaneous Tissue, Fibroma                                  2 (7%)       3 (6%)                                             
      Subcutaneous Tissue, Fibrosarcoma                1 (3%)       9 (33%)      3 (6%)                                             
      Subcutaneous Tissue, Fibrosarcoma, Multiple      1 (3%)       1 (4%)                                                          
      Subcutaneous Tissue,                                                                                                          
                                                             Page   8                                                               
NTP Experiment-Test: 05073-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                 TECHNICAL GRADE PENTACHLOROPHENOL                             Date: 09/09/94  
Route: DOSED FEED                                                                                                 Time: 05:28:16  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 PPM        100 PPM      200 PPM                                                
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - cont                                                                                                         
          Hepatocholangiocarcinoma, Metastatic,                                                                                     
           Liver                                                                 1 (2%)                                             
      Subcutaneous Tissue, Mast Cell Tumor Benign      1 (3%)                                                                       
      Subcutaneous Tissue, Sarcoma                     2 (6%)                    4 (8%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (33)         (18)         (49)                                                
      Alveolar/Bronchiolar Adenoma                     2 (6%)       1 (6%)       5 (10%)                                            
      Alveolar/Bronchiolar Adenoma, Multiple                                     1 (2%)                                             
      Alveolar/Bronchiolar Carcinoma                                1 (6%)                                                          
      Fibrosarcoma, Metastatic, Skin                                1 (6%)                                                          
      Hepatocellular Carcinoma, Metastatic, Liver      1 (3%)                    1 (2%)                                             
      Sarcoma, Metastatic, Skin                        1 (3%)                    2 (4%)                                             
      Sarcoma, Metastatic, Tooth                       1 (3%)                                                                       
      Mediastinum, Hepatocholangiocarcinoma,                                                                                        
          Metastatic, Liver                                                      1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (29)         (12)         (43)                                                
      Adenoma                                          1 (3%)                    2 (5%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (33)         (18)         (47)                                                
      Fibrosarcoma, Metastatic, Skin                   1 (3%)                                                                       
      Hepatocholangiocarcinoma, Metastatic, Liver                                1 (2%)                                             
   Urinary Bladder                                    (34)         (15)         (43)                                                
                                                             Page   9                                                               
NTP Experiment-Test: 05073-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                 TECHNICAL GRADE PENTACHLOROPHENOL                             Date: 09/09/94  
Route: DOSED FEED                                                                                                 Time: 05:28:16  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 PPM        100 PPM      200 PPM                                                
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - cont                                                                                                               
      Hemangioma                                       1 (3%)                                                                       
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(35)        *(49)        *(49)                                                
      Lymphoma Malignant Histiocytic                                1 (2%)       2 (4%)                                             
      Lymphoma Malignant Lymphocytic                                             2 (4%)                                             
      Lymphoma Malignant Mixed                         1 (3%)       1 (2%)       2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  10                                                               
NTP Experiment-Test: 05073-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                 TECHNICAL GRADE PENTACHLOROPHENOL                             Date: 09/09/94  
Route: DOSED FEED                                                                                                 Time: 05:28:16  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 PPM        100 PPM      200 PPM                                                
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            17          38          45                                                   
     Total Primary Neoplasms                           20          63         100                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 11          28          38                                                   
     Total Benign Neoplasms                            12          34          71                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms               8          27          26                                                   
     Total Malignant Neoplasms                          8          29          29                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              5           2           4                                                   
     Total Metastatic Neoplasm                          9           2          10                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  11                                                               
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