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TR 349 Mouse Pathology Tables

NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Columbus                              TECHNICAL GRADE PENTACHLOROPHENOL                          DATE: 09/09/94       
EXPERIMENT: 05073 TEST: 01                                                                                     TIME: 05:37:16       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01-ES-38068          ROUTE: DOSED FEED                                                                  NTP C#: 55378        
PATHOLOGIST: R. PERSING                      S. EUSTIS                                                         CAS: 87-86-5         
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               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08    
LAB: Battelle Columbus                              TECHNICAL GRADE PENTACHLOROPHENOL                          DATE: 09/09/94      
EXPERIMENT: 05073 TEST: 01                                                                                     TIME: 05:37:16      
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                       
CONT: N01-ES-38068          ROUTE: DOSED FEED                                                                  NTP C#: 55378       
PATHOLOGIST: R. PERSING                      S. EUSTIS                                                         CAS: 87-86-5        
 
 
 
 
 
                                                    MICE(B6C3F1)
                                              ----------------------------
             FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
             IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
 
 
                                                    ----------------
 
                                                    Adrenal Gland
                                                    Bone Marrow
                                                    Brain
                                                    Epididymis
                                                    Gallbladder
                                                    Heart
                                                    Islets, Pancreatic
                                                    Kidney
                                                    Liver
                                                    Lung
                                                    Nose
                                                    Ovary
                                                    Pancreas
                                                    Parathyroid Gland
                                                    Pituitary Gland
                                                    Preputial Gland
                                                    Prostate
                                                    Salivary Glands
                                                    Spleen
                                                    Testes
                                                    Thymus
                                                    Thyroid Gland
                                                    Urinary Bladder
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Columbus                              TECHNICAL GRADE PENTACHLOROPHENOL                          DATE: 09/09/94       
EXPERIMENT: 05073 TEST: 01                                                                                     TIME: 05:37:16       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-38068          ROUTE: DOSED FEED                                                                  NTP C#: 55378        
PATHOLOGIST: R. PERSING                      S. EUSTIS                                                         CAS: 87-86-5         
 
 
 
 
 
                                     SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
                               IN THE ANALYSIS OF THE STUDY OF TECHNICAL GRADE PENTACHLOROPHENOL
 
              ====================================================================================================
 
                                                           MALE MICE
                                                          -------------
                                 ORGAN                               MORPHOLOGY
                                -------                             ------------
 
                             Adrenal Medulla               Pheochromocytoma Benign
                                                           Pheochromocytoma: Benign, Complex, Malignant, NOS
                             Liver                         Hepatocellular Adenoma
                                                           Hepatocellular Carcinoma
                                                           Hepatocellular Carcinoma or Hepatocellular Adenoma
                                                           Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
                             All Organs                    Benign Tumors
                                                           Malignant Tumors
                                                           Malignant and Benign Tumors
 
              ====================================================================================================
 
                                                           FEMALE MICE
                                                          -------------
                                 ORGAN                               MORPHOLOGY
                                -------                             ------------
 
                             Liver                         Hemangiosarcoma
                             Lung                          Alveolar/Bronchiolar Adenoma
                                                           Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma
                             Pituitary Gland: Pars Distalis or Unspecified Site
                                                           Adenoma
                                                           Carcinoma or Adenoma
                             Stomach, Forestomach          Squamous Cell Papilloma
                             All Organs                    Hemangiosarcoma
                                                           Hemangiosarcoma or Hemangioma
                                                           Malignant Lymphoma And Histiocytic Sarcoma
                                                           Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed,
                                                            NOS, or Undifferentiated Cell Type
                                                           Malignant Tumors
                                                           Malignant and Benign Tumors
 
              ====================================================================================================
         DATE: 09/09/94                     EXPERIMENT: 05073 TEST: 01                                                 PAGE   1
                      STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TECHNICAL GRADE PENTACHLOROPHENOL
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      0 PPM           100 PPM         200 PPM       |      0 PPM           100 PPM         200 PPM       |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma Benign                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     0/31 (0%)      10/45 (22%)     23/45 (51%)     |     0/33 (0%)       2/48 (4%)       1/49 (2%)      |
|ADJUSTED (b)           |      0.0%           37.9%           84.9%          |      0.0%            4.9%            3.1%          |
|TERMINAL (d)           |     0/12 (0%)       7/23 (30%)     18/22 (82%)     |     0/28 (0%)       2/41 (5%)       1/32 (3%)      |
|FIRST INCIDENCE (DAYS) |      ---             682             549           |      ---             729 (T)         729 (T)       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P<0.001 **      P=0.021 *       P<0.001 **     |     P=0.386         P=0.326         P=0.527        |
|INCIDENTAL TUMOR       |     P<0.001 **      P=0.021 *       P<0.001 **     |     P=0.386         P=0.326         P=0.527        |
|LOGISTIC REGRESSION    |     P<0.001 **      P=0.018 *       P<0.001 **     |     P=0.386         P=0.326         P=0.527        |
|COCHRAN-ARMITAGE       |     P<0.001 **                                     |     P=0.461                                        |
|FISHER EXACT           |                     P=0.003 **      P<0.001 **     |                     P=0.348         P=0.598        |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma Malignant                                                                                                  |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     0/31 (0%)       0/45 (0%)       0/45 (0%)      |     2/33 (6%)       0/48 (0%)       0/49 (0%)      |
|ADJUSTED (b)           |      0.0%            0.0%            0.0%          |      6.5%            0.0%            0.0%          |
|TERMINAL (d)           |     0/12 (0%)       0/23 (0%)       0/22 (0%)      |     1/28 (4%)       0/41 (0%)       0/32 (0%)      |
|FIRST INCIDENCE (DAYS) |      ---             ---             ---           |      605             ---             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |       (e)             (e)             (e)          |     P=0.069N        P=0.166N        P=0.195N       |
|INCIDENTAL TUMOR       |       (e)             (e)             (e)          |     P=0.111N        P=0.424N        P=0.225N       |
|LOGISTIC REGRESSION    |       (e)             (e)             (e)          |     P=0.058N        P=0.169N        P=0.154N       |
|COCHRAN-ARMITAGE       |       (e)                                          |     P=0.056N                                       |
|FISHER EXACT           |                       (e)             (e)          |                     P=0.163N        P=0.159N       |
|=================================================================================================================================|
 
         DATE: 09/09/94                     EXPERIMENT: 05073 TEST: 01                                                 PAGE   2
                      STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TECHNICAL GRADE PENTACHLOROPHENOL
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      0 PPM           100 PPM         200 PPM       |      0 PPM           100 PPM         200 PPM       |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma: Benign, Complex, Malignant, NOS                                                                           |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     0/31 (0%)      10/45 (22%)     23/45 (51%)     |     2/33 (6%)       2/48 (4%)       1/49 (2%)      |
|ADJUSTED (b)           |      0.0%           37.9%           84.9%          |      6.5%            4.9%            3.1%          |
|TERMINAL (d)           |     0/12 (0%)       7/23 (30%)     18/22 (82%)     |     1/28 (4%)       2/41 (5%)       1/32 (3%)      |
|FIRST INCIDENCE (DAYS) |      ---             682             549           |      605             729 (T)         729 (T)       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P<0.001 **      P=0.021 *       P<0.001 **     |     P=0.331N        P=0.555N        P=0.436N       |
|INCIDENTAL TUMOR       |     P<0.001 **      P=0.021 *       P<0.001 **     |     P=0.358N        P=0.632         P=0.469N       |
|LOGISTIC REGRESSION    |     P<0.001 **      P=0.018 *       P<0.001 **     |     P=0.263N        P=0.556N        P=0.364N       |
|COCHRAN-ARMITAGE       |     P<0.001 **                                     |     P=0.258N                                       |
|FISHER EXACT           |                     P=0.003 **      P<0.001 **     |                     P=0.540N        P=0.354N       |
|=================================================================================================================================|
|                                                                                                                                 |
|Bone Marrow                                                                                                                      |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     0/30 (0%)       0/15 (0%)       0/44 (0%)      |     0/35 (0%)       0/4 (0%)        2/49 (4%)      |
|ADJUSTED (b)           |      0.0%            0.0%            0.0%          |      0.0%            0.0%            5.9%          |
|TERMINAL (d)           |     0/12 (0%)       0/0             0/21 (0%)      |     0/29 (0%)       0/0             0/32 (0%)      |
|FIRST INCIDENCE (DAYS) |      ---             ---             ---           |      ---             ---             710           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |       (e)             (e)             (e)          |     P=0.099           (e)           P=0.272        |
|INCIDENTAL TUMOR       |       (e)             (e)             (e)          |     P=0.570           (e)           P=0.795        |
|LOGISTIC REGRESSION    |       (e)             (e)             (e)          |     P=0.186           (e)           P=0.304        |
|COCHRAN-ARMITAGE       |       (e)                                          |     P=0.190                                        |
|FISHER EXACT           |                       (e)             (e)          |                       (e)           P=0.337        |
|=================================================================================================================================|
 
         DATE: 09/09/94                     EXPERIMENT: 05073 TEST: 01                                                 PAGE   3
                      STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TECHNICAL GRADE PENTACHLOROPHENOL
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      0 PPM           100 PPM         200 PPM       |      0 PPM           100 PPM         200 PPM       |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Harderian Gland                                                                                                                  |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     1/35 (3%)       0/49 (0%)       2/49 (4%)      |     2/35 (6%)       0/50 (0%)       1/50 (2%)      |
|ADJUSTED (b)           |      5.6%            0.0%            9.1%          |      6.9%            0.0%            3.1%          |
|TERMINAL (d)           |     0/12 (0%)       0/24 (0%)       2/22 (9%)      |     2/29 (7%)       0/41 (0%)       1/32 (3%)      |
|FIRST INCIDENCE (DAYS) |      552             ---             729 (T)       |      729 (T)         ---             729 (T)       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.513         P=0.351N        P=0.714        |     P=0.329N        P=0.166N        P=0.465N       |
|INCIDENTAL TUMOR       |     P=0.555         P=0.362N        P=0.717N       |     P=0.329N        P=0.166N        P=0.465N       |
|LOGISTIC REGRESSION    |     P=0.494         P=0.460N        P=0.696        |     P=0.329N        P=0.166N        P=0.465N       |
|COCHRAN-ARMITAGE       |     P=0.446                                        |     P=0.268N                                       |
|FISHER EXACT           |                     P=0.417N        P=0.625        |                     P=0.167N        P=0.367N       |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     0/32 (0%)       2/47 (4%)       1/48 (2%)      |     0/33 (0%)       2/49 (4%)       4/50 (8%)      |
|ADJUSTED (b)           |      0.0%            8.3%            4.5%          |      0.0%            4.4%           11.4%          |
|TERMINAL (d)           |     0/12 (0%)       2/24 (8%)       1/22 (5%)      |     0/28 (0%)       1/41 (2%)       1/32 (3%)      |
|FIRST INCIDENCE (DAYS) |      ---             729 (T)         729 (T)       |      ---             424             694           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.505         P=0.400         P=0.621        |     P=0.047 *       P=0.328         P=0.089        |
|INCIDENTAL TUMOR       |     P=0.505         P=0.400         P=0.621        |     P=0.220         P=0.576         P=0.360        |
|LOGISTIC REGRESSION    |     P=0.505         P=0.400         P=0.621        |     P=0.075         P=0.246         P=0.115        |
|COCHRAN-ARMITAGE       |     P=0.464                                        |     P=0.073                                        |
|FISHER EXACT           |                     P=0.351         P=0.600        |                     P=0.354         P=0.125        |
|=================================================================================================================================|
 
         DATE: 09/09/94                     EXPERIMENT: 05073 TEST: 01                                                 PAGE   4
                      STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TECHNICAL GRADE PENTACHLOROPHENOL
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      0 PPM           100 PPM         200 PPM       |      0 PPM           100 PPM         200 PPM       |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Adenoma                                                                                                      |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     5/32 (16%)     20/47 (43%)     33/48 (69%)     |     3/33 (9%)       8/49 (16%)      8/50 (16%)     |
|ADJUSTED (b)           |     27.6%           65.2%           88.6%          |     10.7%           19.5%           24.0%          |
|TERMINAL (d)           |     2/12 (17%)     14/24 (58%)     18/22 (82%)     |     3/28 (11%)      8/41 (20%)      7/32 (22%)     |
|FIRST INCIDENCE (DAYS) |      330             413             376           |      729 (T)         729 (T)         682           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P<0.001 **      P=0.074         P<0.001 **     |     P=0.113         P=0.261         P=0.148        |
|INCIDENTAL TUMOR       |     P<0.001 **      P=0.041 *       P<0.001 **     |     P=0.147         P=0.261         P=0.198        |
|LOGISTIC REGRESSION    |     P<0.001 **      P=0.037 *       P<0.001 **     |     P=0.151         P=0.261         P=0.193        |
|COCHRAN-ARMITAGE       |     P<0.001 **                                     |     P=0.258                                        |
|FISHER EXACT           |                     P=0.010 *       P<0.001 **     |                     P=0.275         P=0.287        |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma                                                                                                    |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     2/32 (6%)      10/47 (21%)     12/48 (25%)     |     0/33 (0%)       1/49 (2%)       1/50 (2%)      |
|ADJUSTED (b)           |     11.4%           33.2%           39.7%          |      0.0%            2.4%            2.5%          |
|TERMINAL (d)           |     0/12 (0%)       5/24 (21%)      6/22 (27%)     |     0/28 (0%)       0/41 (0%)       0/32 (0%)      |
|FIRST INCIDENCE (DAYS) |      498             521             512           |      ---             707             673           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.068         P=0.189         P=0.087        |     P=0.369         P=0.574         P=0.557        |
|INCIDENTAL TUMOR       |     P=0.050         P=0.112         P=0.066        |     P=0.641N        P=0.773         P=0.923        |
|LOGISTIC REGRESSION    |     P=0.046 *       P=0.127         P=0.049 *      |     P=0.412         P=0.582         P=0.584        |
|COCHRAN-ARMITAGE       |     P=0.031 *                                      |     P=0.413                                        |
|FISHER EXACT           |                     P=0.062         P=0.027 *      |                     P=0.598         P=0.602        |
|=================================================================================================================================|
 
         DATE: 09/09/94                     EXPERIMENT: 05073 TEST: 01                                                 PAGE   5
                      STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TECHNICAL GRADE PENTACHLOROPHENOL
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      0 PPM           100 PPM         200 PPM       |      0 PPM           100 PPM         200 PPM       |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma or Hepatocellular Adenoma                                                                          |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     7/32 (22%)     26/47 (55%)     37/48 (77%)     |     3/33 (9%)       9/49 (18%)      9/50 (18%)     |
|ADJUSTED (b)           |     35.8%           75.7%           89.7%          |     10.7%           21.4%           25.9%          |
|TERMINAL (d)           |     2/12 (17%)     16/24 (67%)     18/22 (82%)     |     3/28 (11%)      8/41 (20%)      7/32 (22%)     |
|FIRST INCIDENCE (DAYS) |      330             413             376           |      729 (T)         707             673           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P<0.001 **      P=0.067         P=0.002 **     |     P=0.080         P=0.193         P=0.104        |
|INCIDENTAL TUMOR       |     P<0.001 **      P=0.015 *       P<0.001 **     |     P=0.170         P=0.227         P=0.185        |
|LOGISTIC REGRESSION    |     P<0.001 **      P=0.015 *       P<0.001 **     |     P=0.131         P=0.203         P=0.154        |
|COCHRAN-ARMITAGE       |     P<0.001 **                                     |     P=0.198                                        |
|FISHER EXACT           |                     P=0.003 **      P<0.001 **     |                     P=0.200         P=0.211        |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma                                                         |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     7/32 (22%)     26/47 (55%)     37/48 (77%)     |     3/33 (9%)       9/49 (18%)      9/50 (18%)     |
|ADJUSTED (b)           |     35.8%           75.7%           89.7%          |     10.7%           21.4%           25.9%          |
|TERMINAL (d)           |     2/12 (17%)     16/24 (67%)     18/22 (82%)     |     3/28 (11%)      8/41 (20%)      7/32 (22%)     |
|FIRST INCIDENCE (DAYS) |      330             413             376           |      729 (T)         707             673           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P<0.001 **      P=0.067         P=0.002 **     |     P=0.080         P=0.193         P=0.104        |
|INCIDENTAL TUMOR       |     P<0.001 **      P=0.015 *       P<0.001 **     |     P=0.170         P=0.227         P=0.185        |
|LOGISTIC REGRESSION    |     P<0.001 **      P=0.015 *       P<0.001 **     |     P=0.131         P=0.203         P=0.154        |
|COCHRAN-ARMITAGE       |     P<0.001 **                                     |     P=0.198                                        |
|FISHER EXACT           |                     P=0.003 **      P<0.001 **     |                     P=0.200         P=0.211        |
|=================================================================================================================================|
 
         DATE: 09/09/94                     EXPERIMENT: 05073 TEST: 01                                                 PAGE   6
                      STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TECHNICAL GRADE PENTACHLOROPHENOL
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      0 PPM           100 PPM         200 PPM       |      0 PPM           100 PPM         200 PPM       |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Adenoma                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     2/33 (6%)       1/18 (6%)       6/49 (12%)     |     0/35 (0%)       1/5 (20%)       2/50 (4%)      |
|ADJUSTED (b)           |     16.7%          100.0%           27.3%          |      0.0%          100.0%            6.3%          |
|TERMINAL (d)           |     2/12 (17%)      1/1 (100%)      6/22 (27%)     |     0/29 (0%)       1/1 (100%)      2/32 (6%)      |
|FIRST INCIDENCE (DAYS) |      729 (T)         729 (T)         729 (T)       |      ---             729 (T)         729 (T)       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.354         P=0.261         P=0.394        |     P=0.211         P=0.005 **      P=0.260        |
|INCIDENTAL TUMOR       |     P=0.354         P=0.261         P=0.394        |     P=0.211         P=0.005 **      P=0.260        |
|LOGISTIC REGRESSION    |     P=0.354         P=0.261         P=0.394        |     P=0.211         P=0.005 **      P=0.260        |
|COCHRAN-ARMITAGE       |     P=0.210                                        |     P=0.270                                        |
|FISHER EXACT           |                     P=0.718N        P=0.299        |                     P=0.125         P=0.343        |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma                                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     2/33 (6%)       2/18 (11%)      6/49 (12%)     |     1/35 (3%)       1/5 (20%)       3/50 (6%)      |
|ADJUSTED (b)           |     16.7%          100.0%           27.3%          |      3.4%          100.0%            8.9%          |
|TERMINAL (d)           |     2/12 (17%)      1/1 (100%)      6/22 (27%)     |     1/29 (3%)       1/1 (100%)      2/32 (6%)      |
|FIRST INCIDENCE (DAYS) |      729 (T)         543             729 (T)       |      729 (T)         729 (T)         694           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.388         P=0.174         P=0.394        |     P=0.275         P=0.041 *       P=0.353        |
|INCIDENTAL TUMOR       |     P=0.367         P=0.089         P=0.394        |     P=0.404         P=0.041 *       P=0.492        |
|LOGISTIC REGRESSION    |     P=0.424         P=0.162         P=0.394        |     P=0.334         P=0.041 *       P=0.400        |
|COCHRAN-ARMITAGE       |     P=0.239                                        |     P=0.374                                        |
|FISHER EXACT           |                     P=0.443         P=0.299        |                     P=0.237         P=0.453        |
|=================================================================================================================================|
 
         DATE: 09/09/94                     EXPERIMENT: 05073 TEST: 01                                                 PAGE   7
                      STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TECHNICAL GRADE PENTACHLOROPHENOL
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      0 PPM           100 PPM         200 PPM       |      0 PPM           100 PPM         200 PPM       |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     0/35 (0%)       0/49 (0%)       0/49 (0%)      |     3/35 (9%)       2/50 (4%)       2/50 (4%)      |
|ADJUSTED (b)           |      0.0%            0.0%            0.0%          |     10.3%            4.6%            5.1%          |
|TERMINAL (d)           |     0/12 (0%)       0/24 (0%)       0/22 (0%)      |     3/29 (10%)      1/41 (2%)       1/32 (3%)      |
|FIRST INCIDENCE (DAYS) |      ---             ---             ---           |      729 (T)         656             356           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |       (e)             (e)             (e)          |     P=0.333N        P=0.339N        P=0.429N       |
|INCIDENTAL TUMOR       |       (e)             (e)             (e)          |     P=0.278N        P=0.256N        P=0.464N       |
|LOGISTIC REGRESSION    |       (e)             (e)             (e)          |     P=0.261N        P=0.333N        P=0.337N       |
|COCHRAN-ARMITAGE       |       (e)                                          |     P=0.264N                                       |
|FISHER EXACT           |                       (e)             (e)          |                     P=0.334N        P=0.334N       |
|=================================================================================================================================|
|                                                                                                                                 |
|Ovary                                                                                                                            |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    |     2/30 (7%)       1/23 (4%)       0/48 (0%)      |
|ADJUSTED (b)           |                                                    |      7.7%            5.6%            0.0%          |
|TERMINAL (d)           |                                                    |     2/26 (8%)       1/18 (6%)       0/32 (0%)      |
|FIRST INCIDENCE (DAYS) |                                                    |      729 (T)         729 (T)         ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |     P=0.121N        P=0.629N        P=0.193N       |
|INCIDENTAL TUMOR       |                                                    |     P=0.121N        P=0.629N        P=0.193N       |
|LOGISTIC REGRESSION    |                                                    |     P=0.121N        P=0.629N        P=0.193N       |
|COCHRAN-ARMITAGE       |                                                    |     P=0.083N                                       |
|FISHER EXACT           |                                                    |                     P=0.600N        P=0.145N       |
|=================================================================================================================================|
 
         DATE: 09/09/94                     EXPERIMENT: 05073 TEST: 01                                                 PAGE   8
                      STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TECHNICAL GRADE PENTACHLOROPHENOL
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      0 PPM           100 PPM         200 PPM       |      0 PPM           100 PPM         200 PPM       |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Ovary                                                                                                                            |
|     Luteoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    |     1/30 (3%)       2/23 (9%)       1/48 (2%)      |
|ADJUSTED (b)           |                                                    |      3.8%           11.1%            3.1%          |
|TERMINAL (d)           |                                                    |     1/26 (4%)       2/18 (11%)      1/32 (3%)      |
|FIRST INCIDENCE (DAYS) |                                                    |      729 (T)         729 (T)         729 (T)       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |     P=0.543N        P=0.371         P=0.715N       |
|INCIDENTAL TUMOR       |                                                    |     P=0.543N        P=0.371         P=0.715N       |
|LOGISTIC REGRESSION    |                                                    |     P=0.543N        P=0.371         P=0.715N       |
|COCHRAN-ARMITAGE       |                                                    |     P=0.450N                                       |
|FISHER EXACT           |                                                    |                     P=0.400         P=0.624N       |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     0/29 (0%)       0/12 (0%)       0/41 (0%)      |    11/32 (34%)      8/14 (57%)      5/39 (13%)     |
|ADJUSTED (b)           |      0.0%            0.0%            0.0%          |     37.7%           72.7%           17.6%          |
|TERMINAL (d)           |     0/12 (0%)       0/0             0/21 (0%)      |    10/28 (36%)      8/11 (73%)      3/24 (13%)     |
|FIRST INCIDENCE (DAYS) |      ---             ---             ---           |      605             729 (T)         695           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |       (e)             (e)             (e)          |     P=0.118N        P=0.110         P=0.115N       |
|INCIDENTAL TUMOR       |       (e)             (e)             (e)          |     P=0.057N        P=0.044 *       P=0.042N*      |
|LOGISTIC REGRESSION    |       (e)             (e)             (e)          |     P=0.043N*       P=0.092         P=0.044N*      |
|COCHRAN-ARMITAGE       |       (e)                                          |     P=0.024N*                                      |
|FISHER EXACT           |                       (e)             (e)          |                     P=0.132         P=0.030N*      |
|=================================================================================================================================|
 
         DATE: 09/09/94                     EXPERIMENT: 05073 TEST: 01                                                 PAGE   9
                      STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TECHNICAL GRADE PENTACHLOROPHENOL
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      0 PPM           100 PPM         200 PPM       |      0 PPM           100 PPM         200 PPM       |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     0/29 (0%)       0/12 (0%)       0/41 (0%)      |    11/32 (34%)      8/14 (57%)      6/39 (15%)     |
|ADJUSTED (b)           |      0.0%            0.0%            0.0%          |     37.7%           72.7%           19.7%          |
|TERMINAL (d)           |     0/12 (0%)       0/0             0/21 (0%)      |    10/28 (36%)      8/11 (73%)      3/24 (13%)     |
|FIRST INCIDENCE (DAYS) |      ---             ---             ---           |      605             729 (T)         681           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |       (e)             (e)             (e)          |     P=0.180N        P=0.110         P=0.178N       |
|INCIDENTAL TUMOR       |       (e)             (e)             (e)          |     P=0.061N        P=0.044 *       P=0.042N*      |
|LOGISTIC REGRESSION    |       (e)             (e)             (e)          |     P=0.071N        P=0.092         P=0.077N       |
|COCHRAN-ARMITAGE       |       (e)                                          |     P=0.043N*                                      |
|FISHER EXACT           |                       (e)             (e)          |                     P=0.132         P=0.056N       |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin: Subcutaneous Tissue                                                                                                        |
|     Fibroma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     0/35 (0%)       2/49 (4%)       3/49 (6%)      |     0/35 (0%)       0/50 (0%)       0/50 (0%)      |
|ADJUSTED (b)           |      0.0%            7.6%           12.3%          |      0.0%            0.0%            0.0%          |
|TERMINAL (d)           |     0/12 (0%)       1/24 (4%)       2/22 (9%)      |     0/29 (0%)       0/41 (0%)       0/32 (0%)      |
|FIRST INCIDENCE (DAYS) |      ---             693             654           |      ---             ---             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.161         P=0.420         P=0.249        |       (e)             (e)             (e)          |
|INCIDENTAL TUMOR       |     P=0.153         P=0.435         P=0.254        |       (e)             (e)             (e)          |
|LOGISTIC REGRESSION    |     P=0.160         P=0.411         P=0.250        |       (e)             (e)             (e)          |
|COCHRAN-ARMITAGE       |     P=0.127                                        |       (e)                                          |
|FISHER EXACT           |                     P=0.337         P=0.193        |                       (e)             (e)          |
|=================================================================================================================================|
 
         DATE: 09/09/94                     EXPERIMENT: 05073 TEST: 01                                                 PAGE  10
                      STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TECHNICAL GRADE PENTACHLOROPHENOL
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      0 PPM           100 PPM         200 PPM       |      0 PPM           100 PPM         200 PPM       |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin: Subcutaneous Tissue                                                                                                        |
|     Fibrosarcoma                                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     2/35 (6%)      10/49 (20%)      3/49 (6%)      |     0/35 (0%)       1/50 (2%)       2/50 (4%)      |
|ADJUSTED (b)           |     14.4%           31.9%           12.9%          |      0.0%            2.3%            5.0%          |
|TERMINAL (d)           |     1/12 (8%)       5/24 (21%)      2/22 (9%)      |     0/29 (0%)       0/41 (0%)       0/32 (0%)      |
|FIRST INCIDENCE (DAYS) |      675             521             701           |      ---             705             658           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.338N        P=0.187         P=0.597N       |     P=0.170         P=0.579         P=0.305        |
|INCIDENTAL TUMOR       |     P=0.358N        P=0.110         P=0.588N       |     P=0.576         P=0.814         P=0.795        |
|LOGISTIC REGRESSION    |     P=0.347N        P=0.128         P=0.587N       |     P=0.194         P=0.574         P=0.320        |
|COCHRAN-ARMITAGE       |     P=0.489N                                       |     P=0.193                                        |
|FISHER EXACT           |                     P=0.053         P=0.657        |                     P=0.588         P=0.343        |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin: Subcutaneous Tissue                                                                                                        |
|     Neurofibrosarcoma, Fibrosarcoma, Sarcoma,                                                                                   |
|     Neurofibroma, or Fibroma                                                                                                    |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     4/35 (11%)     12/49 (24%)     10/49 (20%)     |     0/35 (0%)       1/50 (2%)       2/50 (4%)      |
|ADJUSTED (b)           |     24.2%           37.8%           36.1%          |      0.0%            2.3%            5.0%          |
|TERMINAL (d)           |     1/12 (8%)       6/24 (25%)      6/22 (27%)     |     0/29 (0%)       0/41 (0%)       0/32 (0%)      |
|FIRST INCIDENCE (DAYS) |      552             521             446           |      ---             705             658           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.406         P=0.358         P=0.415        |     P=0.170         P=0.579         P=0.305        |
|INCIDENTAL TUMOR       |     P=0.382         P=0.250         P=0.398        |     P=0.576         P=0.814         P=0.795        |
|LOGISTIC REGRESSION    |     P=0.349         P=0.239         P=0.350        |     P=0.194         P=0.574         P=0.320        |
|COCHRAN-ARMITAGE       |     P=0.222                                        |     P=0.193                                        |
|FISHER EXACT           |                     P=0.110         P=0.216        |                     P=0.588         P=0.343        |
|=================================================================================================================================|
 
         DATE: 09/09/94                     EXPERIMENT: 05073 TEST: 01                                                 PAGE  11
                      STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TECHNICAL GRADE PENTACHLOROPHENOL
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      0 PPM           100 PPM         200 PPM       |      0 PPM           100 PPM         200 PPM       |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin: Subcutaneous Tissue                                                                                                        |
|     Neurofibrosarcoma, Fibrosarcoma, or Sarcoma                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     4/35 (11%)     10/49 (20%)      7/49 (14%)     |     0/35 (0%)       1/50 (2%)       2/50 (4%)      |
|ADJUSTED (b)           |     24.2%           31.9%           25.4%          |      0.0%            2.3%            5.0%          |
|TERMINAL (d)           |     1/12 (8%)       5/24 (21%)      4/22 (18%)     |     0/29 (0%)       0/41 (0%)       0/32 (0%)      |
|FIRST INCIDENCE (DAYS) |      552             521             446           |      ---             705             658           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.467N        P=0.495         P=0.580N       |     P=0.170         P=0.579         P=0.305        |
|INCIDENTAL TUMOR       |     P=0.489N        P=0.373         P=0.601N       |     P=0.576         P=0.814         P=0.795        |
|LOGISTIC REGRESSION    |     P=0.533N        P=0.367         P=0.609        |     P=0.194         P=0.574         P=0.320        |
|COCHRAN-ARMITAGE       |     P=0.465                                        |     P=0.193                                        |
|FISHER EXACT           |                     P=0.216         P=0.484        |                     P=0.588         P=0.343        |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin: Subcutaneous Tissue                                                                                                        |
|     Sarcoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     2/35 (6%)       0/49 (0%)       4/49 (8%)      |     0/35 (0%)       0/50 (0%)       0/50 (0%)      |
|ADJUSTED (b)           |     11.5%            0.0%           13.5%          |      0.0%            0.0%            0.0%          |
|TERMINAL (d)           |     0/12 (0%)       0/24 (0%)       2/22 (9%)      |     0/29 (0%)       0/41 (0%)       0/32 (0%)      |
|FIRST INCIDENCE (DAYS) |      552             ---             446           |      ---             ---             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.417         P=0.094N        P=0.652        |       (e)             (e)             (e)          |
|INCIDENTAL TUMOR       |     P=0.415         P=0.091N        P=0.622        |       (e)             (e)             (e)          |
|LOGISTIC REGRESSION    |     P=0.315         P=0.167N        P=0.522        |       (e)             (e)             (e)          |
|COCHRAN-ARMITAGE       |     P=0.323                                        |       (e)                                          |
|FISHER EXACT           |                     P=0.171N        P=0.509        |                       (e)             (e)          |
|=================================================================================================================================|
 
         DATE: 09/09/94                     EXPERIMENT: 05073 TEST: 01                                                 PAGE  12
                      STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TECHNICAL GRADE PENTACHLOROPHENOL
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      0 PPM           100 PPM         200 PPM       |      0 PPM           100 PPM         200 PPM       |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     0/30 (0%)       0/23 (0%)       0/46 (0%)      |     0/33 (0%)       1/13 (8%)       3/47 (6%)      |
|ADJUSTED (b)           |      0.0%            0.0%            0.0%          |      0.0%           14.3%            8.8%          |
|TERMINAL (d)           |     0/12 (0%)       0/5 (0%)        0/22 (0%)      |     0/28 (0%)       1/7 (14%)       1/32 (3%)      |
|FIRST INCIDENCE (DAYS) |      ---             ---             ---           |      ---             729 (T)         710           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |       (e)             (e)             (e)          |     P=0.091         P=0.227         P=0.150        |
|INCIDENTAL TUMOR       |       (e)             (e)             (e)          |     P=0.261         P=0.227         P=0.407        |
|LOGISTIC REGRESSION    |       (e)             (e)             (e)          |     P=0.137         P=0.227         P=0.180        |
|COCHRAN-ARMITAGE       |       (e)                                          |     P=0.145                                        |
|FISHER EXACT           |                       (e)             (e)          |                     P=0.283         P=0.197        |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Squamous Cell Papilloma                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     0/35 (0%)       0/49 (0%)       1/49 (2%)      |     5/35 (14%)      0/50 (0%)       0/50 (0%)      |
|ADJUSTED (b)           |      0.0%            0.0%            4.5%          |     17.2%            0.0%            0.0%          |
|TERMINAL (d)           |     0/12 (0%)       0/24 (0%)       1/22 (5%)      |     5/29 (17%)      0/41 (0%)       0/32 (0%)      |
|FIRST INCIDENCE (DAYS) |      ---             ---             729 (T)       |      729 (T)         ---             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.330           (e)           P=0.621        |     P=0.003N**      P=0.012N*       P=0.025N*      |
|INCIDENTAL TUMOR       |     P=0.330           (e)           P=0.621        |     P=0.003N**      P=0.012N*       P=0.025N*      |
|LOGISTIC REGRESSION    |     P=0.330           (e)           P=0.621        |     P=0.003N**      P=0.012N*       P=0.025N*      |
|COCHRAN-ARMITAGE       |     P=0.307                                        |     P=0.002N**                                     |
|FISHER EXACT           |                       (e)           P=0.583        |                     P=0.010N**      P=0.010N**     |
|=================================================================================================================================|
 
         DATE: 09/09/94                     EXPERIMENT: 05073 TEST: 01                                                 PAGE  13
                      STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TECHNICAL GRADE PENTACHLOROPHENOL
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      0 PPM           100 PPM         200 PPM       |      0 PPM           100 PPM         200 PPM       |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Hemangioma                                                                                                                  |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     1/35 (3%)       0/49 (0%)       2/49 (4%)      |     0/35 (0%)       0/50 (0%)       0/50 (0%)      |
|ADJUSTED (b)           |      3.8%            0.0%            7.2%          |      0.0%            0.0%            0.0%          |
|TERMINAL (d)           |     0/12 (0%)       0/24 (0%)       0/22 (0%)      |     0/29 (0%)       0/41 (0%)       0/32 (0%)      |
|FIRST INCIDENCE (DAYS) |      426             ---             584           |      ---             ---             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.510         P=0.400N        P=0.706        |       (e)             (e)             (e)          |
|INCIDENTAL TUMOR       |     P=0.515         P=0.581N        P=0.707        |       (e)             (e)             (e)          |
|LOGISTIC REGRESSION    |     P=0.418         P=0.554N        P=0.608        |       (e)             (e)             (e)          |
|COCHRAN-ARMITAGE       |     P=0.446                                        |       (e)                                          |
|FISHER EXACT           |                     P=0.417N        P=0.625        |                       (e)             (e)          |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     0/35 (0%)       2/49 (4%)       1/49 (2%)      |     0/35 (0%)       3/50 (6%)       6/50 (12%)     |
|ADJUSTED (b)           |      0.0%            8.3%            4.5%          |      0.0%            6.8%           17.1%          |
|TERMINAL (d)           |     0/12 (0%)       2/24 (8%)       1/22 (5%)      |     0/29 (0%)       2/41 (5%)       3/32 (9%)      |
|FIRST INCIDENCE (DAYS) |      ---             729 (T)         729 (T)       |      ---             424             694           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.505         P=0.400         P=0.621        |     P=0.013 *       P=0.194         P=0.029 *      |
|INCIDENTAL TUMOR       |     P=0.505         P=0.400         P=0.621        |     P=0.054         P=0.317         P=0.106        |
|LOGISTIC REGRESSION    |     P=0.505         P=0.400         P=0.621        |     P=0.024 *       P=0.152         P=0.036 *      |
|COCHRAN-ARMITAGE       |     P=0.446                                        |     P=0.024 *                                      |
|FISHER EXACT           |                     P=0.337         P=0.583        |                     P=0.198         P=0.036 *      |
|=================================================================================================================================|
 
         DATE: 09/09/94                     EXPERIMENT: 05073 TEST: 01                                                 PAGE  14
                      STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TECHNICAL GRADE PENTACHLOROPHENOL
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      0 PPM           100 PPM         200 PPM       |      0 PPM           100 PPM         200 PPM       |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Hemangiosarcoma or Hemangioma                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     1/35 (3%)       2/49 (4%)       3/49 (6%)      |     0/35 (0%)       3/50 (6%)       6/50 (12%)     |
|ADJUSTED (b)           |      3.8%            8.3%           11.4%          |      0.0%            6.8%           17.1%          |
|TERMINAL (d)           |     0/12 (0%)       2/24 (8%)       1/22 (5%)      |     0/29 (0%)       2/41 (5%)       3/32 (9%)      |
|FIRST INCIDENCE (DAYS) |      426             729 (T)         584           |      ---             424             694           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.403         P=0.712         P=0.539        |     P=0.013 *       P=0.194         P=0.029 *      |
|INCIDENTAL TUMOR       |     P=0.407         P=0.612         P=0.538        |     P=0.054         P=0.317         P=0.106        |
|LOGISTIC REGRESSION    |     P=0.366         P=0.661         P=0.460        |     P=0.024 *       P=0.152         P=0.036 *      |
|COCHRAN-ARMITAGE       |     P=0.323                                        |     P=0.024 *                                      |
|FISHER EXACT           |                     P=0.625         P=0.444        |                     P=0.198         P=0.036 *      |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Lymphoma And Histiocytic Sarcoma                                                                                  |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     1/35 (3%)       2/49 (4%)       6/49 (12%)     |    14/35 (40%)      9/50 (18%)     18/50 (36%)     |
|ADJUSTED (b)           |      8.3%            6.6%           24.1%          |     45.0%           21.3%           44.5%          |
|TERMINAL (d)           |     1/12 (8%)       1/24 (4%)       4/22 (18%)     |    12/29 (41%)      8/41 (20%)     11/32 (34%)     |
|FIRST INCIDENCE (DAYS) |      729 (T)         545             640           |      635             692             224           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.093         P=0.726N        P=0.221        |     P=0.349         P=0.026N*       P=0.457        |
|INCIDENTAL TUMOR       |     P=0.093         P=0.612         P=0.238        |     P=0.509         P=0.055N        P=0.539N       |
|LOGISTIC REGRESSION    |     P=0.085         P=0.706         P=0.217        |     P=0.501N        P=0.019N*       P=0.445N       |
|COCHRAN-ARMITAGE       |     P=0.060                                        |     P=0.495N                                       |
|FISHER EXACT           |                     P=0.625         P=0.127        |                     P=0.023N*       P=0.440N       |
|=================================================================================================================================|
 
         DATE: 09/09/94                     EXPERIMENT: 05073 TEST: 01                                                 PAGE  15
                      STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TECHNICAL GRADE PENTACHLOROPHENOL
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      0 PPM           100 PPM         200 PPM       |      0 PPM           100 PPM         200 PPM       |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed,                                                                        |
|     NOS, or Undifferentiated Cell Type                                                                                          |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     1/35 (3%)       2/49 (4%)       6/49 (12%)     |    14/35 (40%)      9/50 (18%)     18/50 (36%)     |
|ADJUSTED (b)           |      8.3%            6.6%           24.1%          |     45.0%           21.3%           44.5%          |
|TERMINAL (d)           |     1/12 (8%)       1/24 (4%)       4/22 (18%)     |    12/29 (41%)      8/41 (20%)     11/32 (34%)     |
|FIRST INCIDENCE (DAYS) |      729 (T)         545             640           |      635             692             224           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.093         P=0.726N        P=0.221        |     P=0.349         P=0.026N*       P=0.457        |
|INCIDENTAL TUMOR       |     P=0.093         P=0.612         P=0.238        |     P=0.509         P=0.055N        P=0.539N       |
|LOGISTIC REGRESSION    |     P=0.085         P=0.706         P=0.217        |     P=0.501N        P=0.019N*       P=0.445N       |
|COCHRAN-ARMITAGE       |     P=0.060                                        |     P=0.495N                                       |
|FISHER EXACT           |                     P=0.625         P=0.127        |                     P=0.023N*       P=0.440N       |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Benign Tumors                                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |    11/35 (31%)     28/49 (57%)     38/49 (78%)     |    17/35 (49%)     17/50 (34%)     19/50 (38%)     |
|ADJUSTED (b)           |     56.4%           84.5%           97.3%          |     56.5%           41.5%           52.6%          |
|TERMINAL (d)           |     5/12 (42%)     19/24 (79%)     21/22 (95%)     |    16/29 (55%)     17/41 (41%)     15/32 (47%)     |
|FIRST INCIDENCE (DAYS) |      330             413             376           |      605             729 (T)         681           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.004 **      P=0.251         P=0.014 *      |     P=0.523         P=0.129N        P=0.581N       |
|INCIDENTAL TUMOR       |     P<0.001 **      P=0.109         P<0.001 **     |     P=0.391N        P=0.189N        P=0.333N       |
|LOGISTIC REGRESSION    |     P<0.001 **      P=0.122         P<0.001 **     |     P=0.363N        P=0.107N        P=0.352N       |
|COCHRAN-ARMITAGE       |     P<0.001 **                                     |     P=0.224N                                       |
|FISHER EXACT           |                     P=0.017 *       P<0.001 **     |                     P=0.130N        P=0.227N       |
|=================================================================================================================================|
 
         DATE: 09/09/94                     EXPERIMENT: 05073 TEST: 01                                                 PAGE  16
                      STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TECHNICAL GRADE PENTACHLOROPHENOL
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      0 PPM           100 PPM         200 PPM       |      0 PPM           100 PPM         200 PPM       |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Tumors                                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     8/35 (23%)     27/49 (55%)     26/49 (53%)     |    19/35 (54%)     17/50 (34%)     30/50 (60%)     |
|ADJUSTED (b)           |     41.6%           70.4%           75.5%          |     59.2%           36.0%           63.5%          |
|TERMINAL (d)           |     2/12 (17%)     13/24 (54%)     14/22 (64%)     |    16/29 (55%)     11/41 (27%)     15/32 (47%)     |
|FIRST INCIDENCE (DAYS) |      475             521             446           |      605             382             224           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.100         P=0.128         P=0.094        |     P=0.092         P=0.071N        P=0.152        |
|INCIDENTAL TUMOR       |     P=0.045 *       P=0.016 *       P=0.038 *      |     P=0.437         P=0.039N*       P=0.489        |
|LOGISTIC REGRESSION    |     P=0.043 *       P=0.024 *       P=0.024 *      |     P=0.431         P=0.049N*       P=0.578N       |
|COCHRAN-ARMITAGE       |     P=0.007 **                                     |     P=0.244                                        |
|FISHER EXACT           |                     P=0.003 **      P=0.005 **     |                     P=0.051N        P=0.381        |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant and Benign Tumors                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |    17/35 (49%)     38/49 (78%)     45/49 (92%)     |    28/35 (80%)     30/50 (60%)     37/50 (74%)     |
|ADJUSTED (b)           |     75.2%           90.4%          100.0%          |     87.5%           63.7%           77.0%          |
|TERMINAL (d)           |     7/12 (58%)     20/24 (83%)     22/22 (100%)    |    25/29 (86%)     24/41 (59%)     21/32 (66%)     |
|FIRST INCIDENCE (DAYS) |      330             413             376           |      605             382             224           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.044 *       P=0.407         P=0.077        |     P=0.208         P=0.069N        P=0.287        |
|INCIDENTAL TUMOR       |     P<0.001 **      P=0.038 *       P<0.001 **     |     P=0.332N        P=0.036N*       P=0.345N       |
|LOGISTIC REGRESSION    |     P<0.001 **      P=0.051         P<0.001 **     |     P=0.417N        P=0.031N*       P=0.363N       |
|COCHRAN-ARMITAGE       |     P<0.001 **                                     |     P=0.400N                                       |
|FISHER EXACT           |                     P=0.006 **      P<0.001 **     |                     P=0.042N*       P=0.354N       |
|=================================================================================================================================|
 
         DATE: 09/09/94                     EXPERIMENT: 05073 TEST: 01                                                 PAGE  17
                      STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- TECHNICAL GRADE PENTACHLOROPHENOL
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
 
 (a)  Number of tumor-bearing animals / number of animals examined at site.
 (b)  Kaplan-Meier estimated lifetime tumor incidence after adjustment for 
      intercurrent mortality.
 (d)  Observed incidence at terminal kill.
 (f)  Beneath the control incidence are the P-values associated with the trend 
      test.  Beneath the dosed group incidence are the P-values corresponding to 
      pairwise comparisons between the controls and that dosed group.  The life
      table analysis regards tumors in animals dying  prior to terminal kill as
      being (directly or indirectly) the cause of death.  The incidental tumor 
      test regards these lesions as non-fatal.  Logistic regression is an alternative
      method for analyzing the incidence of non-fatal tumors.  The Cochran-Armitage
      and Fisher's exact tests compare directly the overall incidence rates.  
      For all tests, a negative trend is indicated by "N".
 (e)  Value of Statistic cannot be computed. 
 (I)  Interim sacrifice
 (T)  Terminal sacrifice
  #   Tumor rates based on number of animals necropsied.
 
  *   To the right of any statistical result, indicates significance at (P<=0.05).
  **  To the right of any statistical result, indicates significance at (P<=0.01).

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