National Toxicology Program

National Toxicology Program
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TR 349 Mouse Pathology Tables

NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11 
LAB: Battelle Columbus                                         DATE: 09/09/94   
EXP: 05073            TECHNICAL GRADE PENTACHLOROPHENOL        TIME: 05:37:17   
TEST: 01              CAGES FROM 0000 TO LAST CAGE             PAGE:   1        
TEST TYPE: CHRONIC          ROUTE: DOSED FEED                  NTP C#: 55378    
CONT: N01-ES-38068                                             CAS: 87-86-5     
PATHOLOGIST: R. PERSING                      S. EUSTIS                          
--------------------------------------------------------------------------------
                                                                                
                                                                                
                                                                                


REASONS FOR REMOVAL:                                                            
                                                                                
ALL                                                                             
                                                                                
                                                                                
REMOVAL DATE RANGE:                                                             


ALL                                                                             
                                                                                
TREATMENT GROUPS:                                                               
                                                                                
INCLUDE ALL                                                                     

NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11
LAB: Battelle Columbus                                         DATE: 09/09/94  
EXP: 05073            TECHNICAL GRADE PENTACHLOROPHENOL        TIME: 05:37:17  
TEST: 01              CAGES FROM 0000 TO LAST CAGE                             
TEST TYPE: CHRONIC          ROUTE: DOSED FEED                  NTP C#: 55378   
CONT: N01-ES-38068                                             CAS: 87-86-5    
PATHOLOGIST: R. PERSING                      S. EUSTIS                         

                         TECHNICAL GRADE PENTACHLOROPHENOL


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 0 PPM                                    |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 35     UNCENSORED DEATHS 23     CENSORED DEATHS 0    TERMINAL 12        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      102   126   187   265   286   330   349   363   417   426                 |
 |      427   427   475   498   510   542   544   552   598   604                 |
 |      675   678   679                                                           |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 100 PPM                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 26     CENSORED DEATHS 0    TERMINAL 24        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      189   315   336   349   350   413   492   521   538   543                 |
 |      545   556   577   587   626   628   635   636   656   664                 |
 |      682   689   693   704   705   708                                         |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 200 PPM                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 24     CENSORED DEATHS 4    TERMINAL 22        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      142   299   446   476   490   512   528   545   549   570                 |
 |      582   584   590   598   619   636   640   644   654   656                 |
 |      680   690   701   710                                                     |
 |  CENSORED DEATHS                                                               |
 |      376   376   376   376                                                     |
 |                                                                                |
 ==================================================================================

                         TECHNICAL GRADE PENTACHLOROPHENOL


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 729 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   729 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |0 PPM      |   100.0  94.3  88.6  77.1  74.3  62.9  51.4  42.9  42.9  34.3      |
 |           |                                                                    |
 |           |                                                                    |
 |100 PPM    |   100.0 100.0  98.0  90.0  88.0  88.0  78.0  72.0  60.0  48.0      |
 |           |                                                                    |
 |           |                                                                    |
 |200 PPM    |   100.0  98.0  98.0  96.0  96.0  91.6  82.9  69.8  56.7  48.0      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                    DOSE                        |
 |                                                                                |
 |                                0 PPM            100 PPM          200 PPM       |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       34.3%            48.0%            48.0%         |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.070N         P=0.078N         P=0.063N      |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       437.4            551.4            564.2         |
 |NATURAL DEATHS (C)      |       (35.1)           (28.2)           (26.5)        |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       537.4            636.7            621.7         |
 |(STANDARD ERROR)        |       (33.0)           (19.3)           (19.8)        |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                         TECHNICAL GRADE PENTACHLOROPHENOL


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 0 PPM                                    |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 35     UNCENSORED DEATHS 6      CENSORED DEATHS 0    TERMINAL 29        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      153   183   605   635   635   674                                         |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 100 PPM                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 9      CENSORED DEATHS 0    TERMINAL 41        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      382   424   453   476   656   675   692   705   707                       |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 200 PPM                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 18     CENSORED DEATHS 0    TERMINAL 32        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      224   356   413   430   495   547   618   634   658   661                 |
 |      673   675   681   682   694   695   710   711                             |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================

                         TECHNICAL GRADE PENTACHLOROPHENOL


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 729 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   729 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |0 PPM      |   100.0  97.1  94.3  94.3  94.3  94.3  94.3  91.4  85.7  82.9      |
 |           |                                                                    |
 |           |                                                                    |
 |100 PPM    |   100.0 100.0 100.0 100.0  96.0  92.0  92.0  92.0  90.0  82.0      |
 |           |                                                                    |
 |           |                                                                    |
 |200 PPM    |   100.0 100.0  98.0  96.0  94.0  92.0  90.0  88.0  80.0  64.0      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                    DOSE                        |
 |                                                                                |
 |                                0 PPM            100 PPM          200 PPM       |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       82.9%            82.0%            64.0%         |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.055          P=1.000          P=0.122       |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       480.8            574.4            586.5         |
 |NATURAL DEATHS (C)      |       (99.4)           (45.5)           (33.8)        |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       686.5            701.2            677.7         |
 |(STANDARD ERROR)        |       (22.5)           (11.5)           (15.4)        |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                                 TECHNICAL GRADE PENTACHLOROPHENOL
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        0 PPM            = 1
                                                        100 PPM          = 2
                                                        200 PPM          = 3

------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1                1     3      2
      |                  1  1  3      2                3  2
      |                     1         1                3  2  2 2              3    3
      |                               1           1                                3 3
   90 +                                                        2         2           3   3
      |                                           1  1                   2            2  3  3
P     |                                              1       1                        2    2323
E     |                                                      1 1                             223
R  80 +                                                        1 1                             3  3
C     |                                                          1        1                   2 2 3 3
E     |                                                                   11                    2  22 3
N     |                                                                                             2 33   2
T  70 +                                                                                                3  3
      |                                                                                                   322
S     |                                                                    1       1                        23 2
U     |                                                                            1   1                       2 2
R  60 +                                                                                11                    3 3 2  2
V     |                                                                                 1     1                3    22
I     |                                                                                                             32 2
V     |                                                                                       11                     3 3
A  50 +                                                                                                                22
L     |                                                                                        1       1                2   2
      |                                                                                                11
      |                                                                                                 1          1
   40 +
      |
      |                                                                                                            1        1
      |
   30 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 16 obs hidden.

                                                 TECHNICAL GRADE PENTACHLOROPHENOL
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        0 PPM            = 1
                                                        100 PPM          = 2
                                                        200 PPM          = 3

----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1                       1          3                         2
      |
      |                                    3                    3    2     2
      |                         1     1
   96 +                                                         3        3 2    2
      |
      |                               1                                  3  3   2  2                    1
      |
   92 +                                                                     3      2  3                        2
      |                                                                                                 1   1
P     |                                                                               3        3               2   2
E     |
R  88 +                                                                                        3          3        2 2
C     |
E     |                                                                                                   3 1      1 2 2
N     |
T  84 +                                                                                                     3  3
      |                                                                                                            1        1
S     |                                                                                                        3 3     2    2
U     |
R  80 +                                                                                                          3 3
V     |
I     |
V     |
A  76 +                                                                                                            33
L     |
      |
      |
   72 +                                                                                                             3 3
      |
      |
      |
   68 +                                                                                                               3 3
      |
      |
      |
   64 +                                                                                                                 3   3
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 3 obs hidden.

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