National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/2109

TR 349 Mouse Pathology Tables


                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                  DOWICIDE EC-7 PENTACHLOROPHENOL


NTP Experiment-Test: 05074-01                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 09/09/94
Route: DOSED FEED                                                                                                 Time: 06:47:16




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  87-86-5

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05074-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                  DOWICIDE EC-7 PENTACHLOROPHENOL                              Date: 09/09/94  
Route: DOSED FEED                                                                                                 Time: 06:47:16  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0 PPM        100 PPM      200 PPM      600 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          35           50           50           50                                     
  Early Deaths                                                                                                                      
    Natural Death                                      3           15           10           11                                     
    Moribund Sacrifice                                 3            6            2                                                  
    Drowned                                                         1                                                               
  Survivors                                                                                                                         
    Terminal Sacrifice                                29           28           38           39                                     
  Animals Examined Microscopically                    35           50           50           49                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (34)         (10)         (3)          (45)                                   
      Peyer's Patch, Hyperplasia, Lymphoid                                                    1 (2%)                                
   Intestine Large, Colon                             (34)         (13)         (4)          (47)                                   
      Parasite Metazoan                                                          1 (25%)                                            
   Intestine Small, Ileum                             (34)         (10)         (3)          (46)                                   
      Peyer's Patch, Hyperplasia, Lymphoid                                                    1 (2%)                                
   Liver                                              (34)         (50)         (49)         (48)                                   
      Basophilic Focus                                 1 (3%)                    1 (2%)                                             
      Clear Cell Focus                                 1 (3%)       2 (4%)       1 (2%)      13 (27%)                               
      Clear Cell Focus, Multiple                                                12 (24%)     13 (27%)                               
      Cytomegaly, Diffuse                                                                     1 (2%)                                
      Degeneration, Cystic                                                       6 (12%)      1 (2%)                                
      Hematopoietic Cell Proliferation, Multifocal    20 (59%)     37 (74%)     35 (71%)     45 (94%)                               
      Infarct                                          2 (6%)       2 (4%)                                                          
      Inflammation, Chronic Active, Diffuse                         4 (8%)      29 (59%)     47 (98%)                               
      Inflammation, Chronic Active, Focal                                        1 (2%)                                             
      Pigmentation, Multifocal                                      4 (8%)      32 (65%)     48 (100%)                              
      Bile Duct, Cyst                                                            1 (2%)       2 (4%)                                
      Bile Duct, Cyst, Multiple                                                  1 (2%)                                             
      Bile Duct, Hyperplasia, Multifocal                                         1 (2%)      40 (83%)                               
      Hepatocyte, Cytomegaly, Diffuse                              37 (74%)     49 (100%)    47 (98%)                               
      Hepatocyte, Cytomegaly, Focal                                 1 (2%)                                                          
      Hepatocyte, Necrosis, Acute, Diffuse                         21 (42%)     49 (100%)    48 (100%)                              
      Hepatocyte, Necrosis, Acute, Focal               2 (6%)       4 (8%)                                                          
   Mesentery                                                       (4)          (1)          (2)                                    
      Inflammation, Acute                                                        1 (100%)                                           
      Inflammation, Chronic Active                                  3 (75%)                                                         
   Pancreas                                           (34)         (16)         (7)          (46)                                   
      Hyperplasia, Lymphoid                                         1 (6%)                                                          
      Acinus, Atrophy                                  5 (15%)      1 (6%)                                                          
      Duct, Cyst                                       1 (3%)       1 (6%)                                                          
      Duct, Ectasia                                    2 (6%)                    1 (14%)                                            
      Duct, Hyperplasia                                1 (3%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05074-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                  DOWICIDE EC-7 PENTACHLOROPHENOL                              Date: 09/09/94  
Route: DOSED FEED                                                                                                 Time: 06:47:16  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0 PPM        100 PPM      200 PPM      600 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Duct, Inflammation, Chronic                      1 (3%)                                                                       
   Salivary Glands                                    (35)         (12)         (3)          (46)                                   
      Hyperplasia, Lymphoid                                                                   1 (2%)                                
   Stomach, Glandular                                 (33)         (13)         (5)          (47)                                   
      Necrosis, Acute, Focal                                        1 (8%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (35)         (14)         (5)          (48)                                   
      Inflammation, Chronic                            1 (3%)                                 1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (35)         (50)         (47)         (49)                                   
      Capsule, Cyst                                    1 (3%)                    1 (2%)                                             
      Capsule, Hyperplasia                            35 (100%)    49 (98%)     47 (100%)    49 (100%)                              
      Corticomedullary Junction, Cyst                                            2 (4%)                                             
   Adrenal Gland, Cortex                              (35)         (49)         (47)         (49)                                   
      Accessory Adrenal Cortical Nodule                             1 (2%)                                                          
      Cyst                                                          1 (2%)                                                          
      Degeneration, Fatty                                                                     2 (4%)                                
      Hematopoietic Cell Proliferation                 1 (3%)       1 (2%)                                                          
      Hyperplasia                                      2 (6%)       1 (2%)                                                          
      Hypertrophy                                      6 (17%)      2 (4%)       5 (11%)                                            
      Hypertrophy, Focal                                                         1 (2%)                                             
   Adrenal Gland, Medulla                             (35)         (49)         (46)         (49)                                   
      Hyperplasia                                      2 (6%)       1 (2%)       5 (11%)     17 (35%)                               
   Pituitary Gland                                    (32)         (17)         (9)          (44)                                   
      Pars Distalis, Cyst                              1 (3%)                                                                       
      Pars Distalis, Hyperplasia                      16 (50%)                   2 (22%)     19 (43%)                               
   Thyroid Gland                                      (34)         (14)         (4)          (46)                                   
      Inflammation, Chronic                            1 (3%)                                 1 (2%)                                
      Ultimobranchial Cyst                                                                    1 (2%)                                
      Follicle, Cyst                                   2 (6%)                    1 (25%)      2 (4%)                                
      Follicular Cell, Hyperplasia                     5 (15%)                                5 (11%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05074-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                  DOWICIDE EC-7 PENTACHLOROPHENOL                              Date: 09/09/94  
Route: DOSED FEED                                                                                                 Time: 06:47:16  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0 PPM        100 PPM      200 PPM      600 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (34)         (24)         (17)         (48)                                   
      Angiectasis                                      2 (6%)                                                                       
      Hyperplasia, Tubular                                                       1 (6%)                                             
      Inflammation, Chronic Active                     3 (9%)       8 (33%)      4 (24%)                                            
      Follicle, Cyst                                  11 (32%)      7 (29%)     10 (59%)     12 (25%)                               
      Periovarian Tissue, Cyst                         3 (9%)       3 (13%)      5 (29%)      3 (6%)                                
   Uterus                                             (34)         (36)         (41)         (47)                                   
      Angiectasis                                                   1 (3%)                                                          
      Inflammation, Acute                                           4 (11%)      4 (10%)                                            
      Inflammation, Chronic Active                                  1 (3%)                    1 (2%)                                
      Thrombosis                                       2 (6%)                                                                       
      Endometrium, Hyperplasia, Cystic, Glandular,                                                                                  
           Multifocal                                 31 (91%)     30 (83%)     37 (90%)     40 (85%)                               
      Endometrium, Hyperplasia, Cystic, Multifocal,                                                                                 
           Reticulum Cell                                                        1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Blood                                                           (1)                                                              
      Lymphocytosis                                                 1 (100%)                                                        
   Bone Marrow                                        (35)         (13)         (5)          (48)                                   
      Femoral, Hyperplasia, Diffuse, Neutrophil                                  1 (20%)                                            
      Femoral, Hyperplasia, Neutrophil                              3 (23%)      1 (20%)                                            
      Femoral, Myelofibrosis                          13 (37%)                   1 (20%)     20 (42%)                               
   Lymph Node                                         (34)         (23)         (11)         (44)                                   
      Lumbar, Hematopoietic Cell Proliferation                                                1 (2%)                                
      Mediastinal, Hyperplasia, Lymphoid                            1 (4%)                                                          
      Mediastinal, Inflammation, Acute                              1 (4%)                                                          
      Mesenteric, Hematopoietic Cell Proliferation                  1 (4%)       4 (36%)      4 (9%)                                
      Mesenteric, Hematopoietic Cell Proliferation,                                                                                 
           Multifocal                                                                         3 (7%)                                
      Mesenteric, Hyperplasia, Lymphoid                1 (3%)                                                                       
      Renal, Hematopoietic Cell Proliferation                                                 1 (2%)                                
      Renal, Hyperplasia, Lymphoid                     1 (3%)                                                                       
   Lymph Node, Mandibular                             (33)         (16)         (4)          (42)                                   
      Hyperplasia, Lymphoid                            1 (3%)       1 (6%)                    2 (5%)                                
      Pigmentation, Diffuse                            1 (3%)                                                                       
   Spleen                                             (34)         (26)         (17)         (47)                                   
      Depletion Lymphoid                                                                      1 (2%)                                
      Hemorrhage                                                                 1 (6%)                                             
      Hyperplasia, Lymphoid                                         1 (4%)                    2 (4%)                                
      Necrosis                                         1 (3%)                    1 (6%)                                             
      Red Pulp, Hematopoietic Cell Proliferation,                                                                                   
           Diffuse                                     1 (3%)       8 (31%)      5 (29%)      5 (11%)                               
   Thymus                                             (30)         (9)          (5)          (43)                                   
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05074-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                  DOWICIDE EC-7 PENTACHLOROPHENOL                              Date: 09/09/94  
Route: DOSED FEED                                                                                                 Time: 06:47:16  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0 PPM        100 PPM      200 PPM      600 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Degeneration, Acute                              1 (3%)                                                                       
      Inflammation, Acute                                                        1 (20%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (33)         (6)          (7)          (40)                                   
      Hyperplasia, Cystic                             19 (58%)      2 (33%)                  31 (78%)                               
   Skin                                               (35)         (22)         (18)         (46)                                   
      Alopecia                                         5 (14%)      1 (5%)       7 (39%)      2 (4%)                                
      Ulcer                                                                                   1 (2%)                                
      Sebaceous Gland, Hyperplasia                                                            1 (2%)                                
      Subcutaneous Tissue, Inflammation, Chronic                                                                                    
          Active                                                                              1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (35)         (14)         (5)          (49)                                   
      Femur, Hyperostosis                                                                     1 (2%)                                
      Joint, Tarsal, Hyperostosis                                                1 (20%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (35)         (14)         (5)          (47)                                   
      Compression                                      1 (3%)                                                                       
      Meninges, Infiltration Cellular, Lymphocyte      6 (17%)                                5 (11%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (35)         (15)         (6)          (48)                                   
      Hyperplasia, Lymphoid                                                                   2 (4%)                                
      Alveolar Epithelium, Hyperplasia                 1 (3%)                                 1 (2%)                                
      Interstitium, Inflammation, Chronic Active                                 1 (17%)                                            
      Mediastinum, Inflammation, Acute                                           2 (33%)                                            
   Nose                                               (35)         (14)         (5)          (48)                                   
      Glands, Inflammation, Acute, Focal                                         2 (40%)     46 (96%)                               
      Olfactory Epithelium, Metaplasia, Focal          1 (3%)                    2 (40%)     45 (94%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05074-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                  DOWICIDE EC-7 PENTACHLOROPHENOL                              Date: 09/09/94  
Route: DOSED FEED                                                                                                 Time: 06:47:16  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0 PPM        100 PPM      200 PPM      600 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                             (1)                                                              
      Atrophy                                                       1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (34)         (15)         (8)          (48)                                   
      Infarct                                                                                 1 (2%)                                
      Nephropathy, Chronic                             3 (9%)                                 3 (6%)                                
      Glomerulus, Amyloid Deposition, Diffuse                       1 (7%)                                                          
      Glomerulus, Inflammation, Chronic, Diffuse                                              1 (2%)                                
      Renal Tubule, Dilatation                                      1 (7%)                                                          
      Renal Tubule, Regeneration                       2 (6%)                                 5 (10%)                               
   Urinary Bladder                                    (34)         (12)         (5)          (47)                                   
      Dilatation                                                    1 (8%)                                                          
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05074-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                  DOWICIDE EC-7 PENTACHLOROPHENOL                              Date: 09/09/94  
Route: DOSED FEED                                                                                                 Time: 06:47:16  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0 PPM        100 PPM      200 PPM      600 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          35           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 2            3            4            6                                     
    Natural Death                                      8           19           17            9                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                25           28           29           35                                     
  Animals Examined Microscopically                    35           50           50           49                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Rectum                            (31)         (6)          (8)          (47)                                   
      Prolapse                                                                                1 (2%)                                
   Liver                                              (35)         (48)         (48)         (49)                                   
      Basophilic Focus                                 1 (3%)       3 (6%)                    2 (4%)                                
      Clear Cell Focus                                              2 (4%)                    4 (8%)                                
      Clear Cell Focus, Multiple                                   17 (35%)     21 (44%)     15 (31%)                               
      Degeneration, Cystic                                          2 (4%)       1 (2%)                                             
      Hematopoietic Cell Proliferation, Diffuse                     1 (2%)                                                          
      Hematopoietic Cell Proliferation, Multifocal     1 (3%)      20 (42%)     16 (33%)     40 (82%)                               
      Hyperplasia, Focal                                            2 (4%)       3 (6%)                                             
      Infarct                                          2 (6%)       1 (2%)       1 (2%)       2 (4%)                                
      Inflammation, Acute                              1 (3%)                                                                       
      Inflammation, Chronic Active, Diffuse                        36 (75%)     44 (92%)     43 (88%)                               
      Pigmentation, Multifocal                                     40 (83%)     37 (77%)     45 (92%)                               
      Thrombosis, Multiple                                          1 (2%)                                                          
      Bile Canaliculi, Hyperplasia, Atypical,                                                                                       
          Diffuse                                                   1 (2%)                                                          
      Bile Duct, Cyst                                               2 (4%)       3 (6%)       1 (2%)                                
      Bile Duct, Cyst, Multifocal                                                2 (4%)                                             
      Bile Duct, Cyst, Multiple                                     2 (4%)                                                          
      Bile Duct, Hyperplasia, Multifocal               1 (3%)       3 (6%)       5 (10%)     32 (65%)                               
      Hepatocyte, Cytomegaly, Diffuse                              48 (100%)    48 (100%)    47 (96%)                               
      Hepatocyte, Necrosis, Acute, Diffuse                         47 (98%)     47 (98%)     46 (94%)                               
      Hepatocyte, Necrosis, Acute, Focal               1 (3%)                                                                       
   Pancreas                                           (34)         (12)         (14)         (49)                                   
      Acinus, Atrophy                                  2 (6%)       1 (8%)                                                          
      Acinus, Degeneration                                                                    1 (2%)                                
      Acinus, Inflammation, Chronic                                                           1 (2%)                                
      Duct, Ectasia                                                 1 (8%)                                                          
   Stomach, Forestomach                               (33)         (11)         (15)         (49)                                   
      Acanthosis                                                    1 (9%)                    2 (4%)                                
      Hyperkeratosis                                                1 (9%)                                                          
      Inflammation, Acute                              1 (3%)                                                                       
      Inflammation, Chronic Active                                                            1 (2%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05074-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                  DOWICIDE EC-7 PENTACHLOROPHENOL                              Date: 09/09/94  
Route: DOSED FEED                                                                                                 Time: 06:47:16  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0 PPM        100 PPM      200 PPM      600 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Ulcer                                                         1 (9%)                    1 (2%)                                
   Stomach, Glandular                                 (33)         (11)         (15)         (49)                                   
      Dysplasia                                                                               3 (6%)                                
      Ulcer, Acute                                     1 (3%)                                                                       
   Tooth                                                                                     (3)                                    
      Developmental Malformation                                                              1 (33%)                               
      Peridontal Tissue, Inflammation, Chronic                                                                                      
          Active                                                                              2 (67%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (35)         (13)         (17)         (49)                                   
      Degeneration, Chronic                                                      1 (6%)                                             
      Mineralization                                   1 (3%)                                                                       
      Atrium, Thrombosis                                                         1 (6%)       2 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (34)         (48)         (49)         (49)                                   
      Capsule, Ectopic Tissue                          3 (9%)                                                                       
      Capsule, Hyperplasia                            30 (88%)     34 (71%)     34 (69%)     29 (59%)                               
   Adrenal Gland, Cortex                              (34)         (48)         (48)         (49)                                   
      Cyst                                             1 (3%)                                                                       
      Cytoplasmic Alteration                                        1 (2%)                                                          
      Hematopoietic Cell Proliferation                              1 (2%)                                                          
      Hyperplasia                                      6 (18%)      7 (15%)      1 (2%)       1 (2%)                                
      Hypertrophy                                      4 (12%)      3 (6%)       6 (13%)      1 (2%)                                
   Adrenal Gland, Medulla                             (34)         (48)         (48)         (49)                                   
      Hyperplasia                                      1 (3%)      19 (40%)     13 (27%)      1 (2%)                                
   Pituitary Gland                                    (29)         (9)          (14)         (38)                                   
      Pars Distalis, Cyst                              1 (3%)                                                                       
   Thyroid Gland                                      (35)         (11)         (14)         (48)                                   
      Follicle, Cyst                                   1 (3%)                                                                       
      Follicular Cell, Hyperplasia                     3 (9%)                                 2 (4%)                                
      Follicular Cell, Hypertrophy                                  1 (9%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05074-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                  DOWICIDE EC-7 PENTACHLOROPHENOL                              Date: 09/09/94  
Route: DOSED FEED                                                                                                 Time: 06:47:16  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0 PPM        100 PPM      200 PPM      600 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (35)         (13)         (18)         (49)                                   
      Granuloma Sperm                                                                         1 (2%)                                
      Spermatocele                                                  1 (8%)                                                          
   Penis                                              (6)          (6)          (1)          (4)                                    
      Inflammation, Acute                                                                     1 (25%)                               
      Inflammation, Chronic Active                     3 (50%)      1 (17%)      1 (100%)                                           
   Preputial Gland                                    (3)          (8)          (4)          (4)                                    
      Dilatation                                                    1 (13%)                                                         
      Hyperplasia                                                   1 (13%)                                                         
      Inflammation, Chronic Active                     1 (33%)      6 (75%)      4 (100%)     4 (100%)                              
      Duct, Dilatation                                 2 (67%)      2 (25%)                   2 (50%)                               
   Prostate                                           (34)         (11)         (15)         (49)                                   
      Inflammation, Acute                                           1 (9%)       3 (20%)                                            
      Inflammation, Chronic Active                     1 (3%)       1 (9%)       1 (7%)                                             
   Seminal Vesicle                                    (1)          (3)          (2)          (1)                                    
      Dilatation                                                    2 (67%)                                                         
      Inflammation, Chronic Active                     1 (100%)     1 (33%)                                                         
   Testes                                             (35)         (12)         (18)         (49)                                   
      Inflammation, Chronic Active                     1 (3%)                                                                       
      Germinal Epithelium, Degeneration                                                       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Blood                                              (3)                       (1)                                                 
      Neutrophilia                                     3 (100%)                  1 (100%)                                           
   Bone Marrow                                        (35)         (10)         (14)         (49)                                   
      Femoral, Hyperplasia, Diffuse, Neutrophil                     1 (10%)                                                         
      Femoral, Hyperplasia, Neutrophil                 2 (6%)       1 (10%)      1 (7%)                                             
   Lymph Node                                         (31)         (14)         (22)         (47)                                   
      Angiectasis                                                   1 (7%)                                                          
      Hyperplasia, Plasma Cell                                      1 (7%)                                                          
      Lumbar, Hyperplasia, Lymphoid                    1 (3%)                                                                       
      Mesenteric, Hematopoietic Cell Proliferation     5 (16%)      4 (29%)     10 (45%)     10 (21%)                               
      Mesenteric, Hematopoietic Cell Proliferation,                                                                                 
           Multifocal                                  1 (3%)       1 (7%)                                                          
      Mesenteric, Hyperplasia, Lymphoid                                                       1 (2%)                                
      Pancreatic, Inflammation, Chronic Active         1 (3%)                                                                       
   Lymph Node, Mandibular                             (31)         (8)          (13)         (47)                                   
      Depletion Lymphoid                                                         1 (8%)                                             
      Hyperplasia, Lymphoid                                                                   1 (2%)                                
      Necrosis                                                                   1 (8%)                                             
   Spleen                                             (34)         (19)         (20)         (49)                                   
      Angiectasis                                      1 (3%)                                                                       
      Cyst                                                          1 (5%)                                                          
      Depletion Lymphoid                               5 (15%)      3 (16%)      6 (30%)      2 (4%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05074-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                  DOWICIDE EC-7 PENTACHLOROPHENOL                              Date: 09/09/94  
Route: DOSED FEED                                                                                                 Time: 06:47:16  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0 PPM        100 PPM      200 PPM      600 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Necrosis                                                                   1 (5%)                                             
      Red Pulp, Hematopoietic Cell Proliferation,                                                                                   
           Diffuse                                     5 (15%)      8 (42%)      7 (35%)      7 (14%)                               
   Thymus                                             (21)         (5)          (11)         (27)                                   
      Necrosis, Acute                                                                         1 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (34)         (32)         (26)         (49)                                   
      Acanthosis                                       3 (9%)       3 (9%)       1 (4%)      10 (20%)                               
      Alopecia                                         5 (15%)      8 (25%)      2 (8%)      12 (24%)                               
      Cyst Epithelial Inclusion                                     1 (3%)                                                          
      Hyperkeratosis                                                1 (3%)                                                          
      Inflammation, Acute                              1 (3%)                                                                       
      Inflammation, Chronic Active                                               1 (4%)                                             
      Metaplasia, Focal, Osseous                       1 (3%)                                                                       
      Necrosis                                         1 (3%)                                                                       
      Ulcer                                            2 (6%)       5 (16%)      4 (15%)      5 (10%)                               
      Ulcer, Focal                                                               1 (4%)                                             
      Subcutaneous Tissue, Fibrosis                                                           1 (2%)                                
      Subcutaneous Tissue, Inflammation, Acute                                   2 (8%)       2 (4%)                                
      Subcutaneous Tissue, Inflammation, Chronic                    1 (3%)                                                          
      Subcutaneous Tissue, Inflammation, Chronic                                                                                    
          Active                                       2 (6%)       3 (9%)       5 (19%)      2 (4%)                                
      Subcutaneous Tissue, Mineralization                                                     1 (2%)                                
      Subcutaneous Tissue, Necrosis, Acute                                       1 (4%)                                             
      Subcutaneous Tissue, Lymphatic, Dilatation       3 (9%)                                 1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (35)         (36)         (29)         (49)                                   
      Joint, Tarsal, Hyperostosis                     18 (51%)     26 (72%)     14 (48%)     12 (24%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (35)         (12)         (16)         (49)                                   
      Cyst Epithelial Inclusion                        1 (3%)                                                                       
      Meninges, Infiltration Cellular, Lymphocyte      1 (3%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05074-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                  DOWICIDE EC-7 PENTACHLOROPHENOL                              Date: 09/09/94  
Route: DOSED FEED                                                                                                 Time: 06:47:16  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0 PPM        100 PPM      200 PPM      600 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (35)         (15)         (19)         (49)                                   
      Alveolar Epithelium, Hyperplasia                 1 (3%)       1 (7%)                    2 (4%)                                
      Alveolar Epithelium, Hyperplasia, Focal                       1 (7%)                                                          
      Alveolar Epithelium, Bronchiole, Hyperplasia                                            1 (2%)                                
      Peribronchiolar, Glands, Inflammation, Acute                                            1 (2%)                                
      Perivascular, Infiltration Cellular,                                                                                          
          Lymphocyte                                                                          2 (4%)                                
   Nose                                               (35)         (13)         (16)         (49)                                   
      Glands, Inflammation, Acute, Focal               4 (11%)      1 (8%)       3 (19%)     47 (96%)                               
      Nasolacrimal Duct, Inflammation, Acute, Focal                 1 (8%)                    2 (4%)                                
      Olfactory Epithelium, Atrophy                                              1 (6%)                                             
      Olfactory Epithelium, Metaplasia, Focal          2 (6%)       1 (8%)       2 (13%)     46 (94%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                             (1)                       (1)                                    
      Cornea, Hyperplasia, Focal                                    1 (100%)                                                        
      Lens, Cataract                                                                          1 (100%)                              
   Harderian Gland                                    (27)         (12)         (13)         (35)                                   
      Inflammation, Chronic Active                                                            1 (3%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (35)         (14)         (20)         (49)                                   
      Cyst                                                                                    4 (8%)                                
      Hydronephrosis                                   1 (3%)       1 (7%)       1 (5%)                                             
      Infarct                                          1 (3%)                                                                       
      Inflammation, Acute                                           2 (14%)      1 (5%)                                             
      Inflammation, Chronic Active                     3 (9%)                    2 (10%)                                            
      Nephropathy, Chronic                             1 (3%)                                 1 (2%)                                
      Capsule, Fibrosis                                1 (3%)                                                                       
      Pelvis, Inflammation, Acute                                                1 (5%)                                             
      Renal Tubule, Dilatation                         3 (9%)                    2 (10%)      1 (2%)                                
      Renal Tubule, Dilatation, Diffuse                                          1 (5%)                                             
      Renal Tubule, Metaplasia, Osseous                                          1 (5%)                                             
      Renal Tubule, Mineralization                                               1 (5%)                                             
      Renal Tubule, Regeneration                      12 (34%)                               17 (35%)                               
   Urethra                                            (3)          (2)          (4)                                                 
      Calculus Micro Observation Only                  2 (67%)      1 (50%)      2 (50%)                                            
      Inflammation, Acute                                           1 (50%)      3 (75%)                                            
      Inflammation, Chronic Active                     1 (33%)                                                                      
   Urinary Bladder                                    (33)         (11)         (15)         (49)                                   
      Calculus Micro Observation Only                  1 (3%)                                                                       
      Dilatation                                       5 (15%)      3 (27%)      8 (53%)      3 (6%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
NTP Experiment-Test: 05074-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                  DOWICIDE EC-7 PENTACHLOROPHENOL                              Date: 09/09/94  
Route: DOSED FEED                                                                                                 Time: 06:47:16  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0 PPM        100 PPM      200 PPM      600 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Inflammation, Acute                                           1 (9%)                                                          
      Inflammation, Chronic Active                     1 (3%)                    1 (7%)                                             
      Mucosa, Hyperplasia                              1 (3%)       1 (9%)       1 (7%)                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   12                                                              
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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.