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TR 349 Mouse Pathology Tables

NTP Experiment-Test: 05074-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  PENTACHLOROPHENOL, DOWICIDE EC7                              Date: 05/05/97
Route: DOSED FEED                                                                                                 Time: 14:43:51




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  87-86-5

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































Note:  Animals arranged according to CID number

                                                              Page   1

NTP Experiment-Test: 05074-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  PENTACHLOROPHENOL, DOWICIDE EC7                              Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 14:43:51  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 2| 2| 2| 8| 2| 3| 2| 2| 2| 2| 3| 2| 4| 2| 2| 2| 2| 2| 3| 2| 3| 2| 2| 3| 9|             
                                           | 7| 2| 8| 5| 8| 0| 9| 9| 8| 9| 0| 8| 3| 8| 8| 7| 7| 8| 0| 8| 0| 8| 7| 0| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leiomyoma                            |                                              X                           |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Peyer's Patch, Lymphoma Malignant    |                                                                          |             
          Histiocytic                      |                                                                          |             
      Peyer's Patch, Lymphoma Malignant    |                                                                          |             
          Lymphocytic                      |                      X                          X     X                  |             
      Peyer's Patch, Lymphoma Malignant    |                                                                          |             
          Mixed                            |                                           X                              |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Adenoma               |                                                                          |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                               X                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |       X                 X                                X               |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +     +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Squamous Cell Papilloma              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +     +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               |    X                    X                    X     X              X  X   |             
      Pars Distalis, Adenoma, Multiple     |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Adenoma             |                         X                          X                     |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05074-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  PENTACHLOROPHENOL, DOWICIDE EC7                              Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 14:43:51  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 2| 2| 2| 8| 2| 3| 2| 2| 2| 2| 3| 2| 4| 2| 2| 2| 2| 2| 3| 2| 3| 2| 2| 3| 9|             
                                           | 7| 2| 8| 5| 8| 0| 9| 9| 8| 9| 0| 8| 3| 8| 8| 7| 7| 8| 0| 8| 0| 8| 7| 0| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Periovarian Tissue, Lymphoma         |                                                                          |             
          Malignant Mixed                  |                                           X                              |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |          X                                                               |             
      Lumbar, Lymphoma Malignant           |                                                                          |             
          Histiocytic                      |                                                                          |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Histiocytic                      |                                                                          |             
      Mediastinal, Lymphoma Malignant Mixed|                                                    X                     |             
      Mesenteric, Lymphoma Malignant       |                                                                          |             
          Histiocytic                      |                                                                          |             
      Mesenteric, Lymphoma Malignant Mixed |                                           X        X                     |             
      Renal, Lymphoma Malignant Histiocytic|                                                                          |             
      Renal, Lymphoma Malignant Mixed      |                                                    X                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +     +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |       X        X     X  X     X                 X     X  X               |             
      Lymphoma Malignant Mixed             |                                           X                 X            |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |       X  X     X        X     X                 X     X  X               |             
      Lymphoma Malignant Mixed             |                                           X                 X            |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  M  M  M  +  +  +  +  +  +  +  +  M  +  +|             
      Lymphoma Malignant Mixed             |                                           X                              |             
      Thymoma Malignant                    |                                                    X                     |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Adenocarcinoma                       |                               X                                      X   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05074-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  PENTACHLOROPHENOL, DOWICIDE EC7                              Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 14:43:51  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 2| 2| 2| 8| 2| 3| 2| 2| 2| 2| 3| 2| 4| 2| 2| 2| 2| 2| 3| 2| 3| 2| 2| 3| 9|             
                                           | 7| 2| 8| 5| 8| 0| 9| 9| 8| 9| 0| 8| 3| 8| 8| 7| 7| 8| 0| 8| 0| 8| 7| 0| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma, Metastatic, Mammary  |                                                                          |             
          Gland                            |                                                                      X   |             
      Alveolar/Bronchiolar Adenoma         |                                           X                              |             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Multiple                         |                                                                          |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Mediastinum, Lymphoma Malignant      |                                                                          |             
          Lymphocytic                      |          X                                                               |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +     +  M  +  M  +  +  +  +|             
      Adenoma                              |                                              X                           |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |       X  X     X        X     X                       X  X               |             
      Lymphoma Malignant Mixed             |                                           X                              |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                    X                     |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |       X  X     X     X  X     X                 X     X  X               |             
      Lymphoma Malignant Mixed             |                                           X        X        X            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05074-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  PENTACHLOROPHENOL, DOWICIDE EC7                              Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 14:43:51  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 1| 2| 2| 3| 3| 2| 2| 2| 2| 2|                                            |            |
                                           | 7| 8| 0| 0| 0| 7| 7| 8| 7| 9|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |     A      |
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  34        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  M  +                                             |  32        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +                                             |  34        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  34        |
      Leiomyoma                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  34        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  34        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +                                             |  34        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  34        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  34        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  34        |
      Peyer's Patch, Lymphoma Malignant    |                                                                          |            |
          Histiocytic                      |       X                                                                  |          1 |
      Peyer's Patch, Lymphoma Malignant    |                                                                          |            |
          Lymphocytic                      |                      X                                                   |          4 |
      Peyer's Patch, Lymphoma Malignant    |                                                                          |            |
          Mixed                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  34        |
      Hepatocellular Adenoma               |                            X                                             |          1 |
      Lymphoma Malignant Histiocytic       |       X                                                                  |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  34        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  35        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +                                             |  34        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  33        |
      Squamous Cell Papilloma              |                X                                                         |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  33        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  35        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  35        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +                                             |  35        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +                                             |  35        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  34        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +                                             |  35        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | M  +  +  +  I  +  +  +  +  +                                             |  32        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page   5                                                               
NTP Experiment-Test: 05074-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  PENTACHLOROPHENOL, DOWICIDE EC7                              Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 14:43:51  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 1| 2| 2| 3| 3| 2| 2| 2| 2| 2|                                            |            |
                                           | 7| 8| 0| 0| 0| 7| 7| 8| 7| 9|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |     A      |
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Pars Distalis, Adenoma               |    X           X           X                                             |          9 |
      Pars Distalis, Adenoma, Multiple     |       X                                                                  |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  34        |
      Follicular Cell, Adenoma             |          X                                                               |          3 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  34        |
      Periovarian Tissue, Lymphoma         |                                                                          |            |
          Malignant Mixed                  |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  34        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  35        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +                                             |  34        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lumbar, Lymphoma Malignant           |                                                                          |            |
          Histiocytic                      |       X                                                                  |          1 |
      Mediastinal, Lymphoma Malignant      |                                                                          |            |
          Histiocytic                      |       X                                                                  |          1 |
      Mediastinal, Lymphoma Malignant Mixed|                                                                          |          1 |
      Mesenteric, Lymphoma Malignant       |                                                                          |            |
          Histiocytic                      |       X                                                                  |          1 |
      Mesenteric, Lymphoma Malignant Mixed |                                                                          |          2 |
      Renal, Lymphoma Malignant Histiocytic|       X                                                                  |          1 |
      Renal, Lymphoma Malignant Mixed      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  33        |
      Lymphoma Malignant Histiocytic       |       X                                                                  |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          8 |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  34        |
      Lymphoma Malignant Histiocytic       |       X                                                                  |          1 |
      Lymphoma Malignant Lymphocytic       |                   X  X                                                   |         10 |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +     +  +                                             |  30        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Thymoma Malignant                    |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page   6                                                               
NTP Experiment-Test: 05074-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  PENTACHLOROPHENOL, DOWICIDE EC7                              Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 14:43:51  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 1| 2| 2| 3| 3| 2| 2| 2| 2| 2|                                            |            |
                                           | 7| 8| 0| 0| 0| 7| 7| 8| 7| 9|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |     A      |
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  +  +  +  +  +  +  +  +  +                                             |  33        |
      Adenocarcinoma                       |    X                                                                     |          3 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  35        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  35        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                      +                                                   |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  35        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  35        |
      Adenocarcinoma, Metastatic, Mammary  |                                                                          |            |
          Gland                            |                                                                          |          1 |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          1 |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Multiple                         |          X                                                               |          1 |
      Lymphoma Malignant Histiocytic       |       X                                                                  |          1 |
      Mediastinum, Lymphoma Malignant      |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  35        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  34        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +  +  M  +  +  +  +  +  +  +                                             |  29        |
      Adenoma                              |             X                                                            |          2 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  34        |
      Lymphoma Malignant Lymphocytic       |                   X                                                      |          8 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  34        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +                                             |  35        |
      Lymphoma Malignant Histiocytic       |       X                                                                  |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page   7                                                               
NTP Experiment-Test: 05074-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  PENTACHLOROPHENOL, DOWICIDE EC7                              Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 14:43:51  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 1| 2| 2| 3| 3| 2| 2| 2| 2| 2|                                            |            |
                                           | 7| 8| 0| 0| 0| 7| 7| 8| 7| 9|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |     A      |
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Lymphoma Malignant Lymphocytic       |                   X  X                                                   |         11 |
      Lymphoma Malignant Mixed             |                                                                          |          3 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page   8                                                               
NTP Experiment-Test: 05074-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  PENTACHLOROPHENOL, DOWICIDE EC7                              Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 14:43:51  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 5| 6| 5| 7| 7| 4| 7| 4| 3| 7| 7| 7| 6|             
                             DAY ON TEST   | 5| 2| 2| 2| 0| 2| 3| 2| 2| 3| 2| 2| 6| 2| 9| 3| 2| 4| 2| 8| 2| 2| 2| 2| 4|             
                                           | 4| 8| 9| 8| 1| 7| 0| 7| 8| 0| 1| 7| 6| 9| 6| 0| 7| 3| 7| 3| 1| 7| 9| 7| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    100 PPM                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +                             +     +  +  +        +     +  +            |             
                                            __________________________________________________________________________|             
   Gallbladder                             | A                             +     +  A  +        +     +  +            |             
                                            __________________________________________________________________________|             
   Intestine Large                         | A                             +     +  +  +        +     +  +            |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | A                             +     +  A  +        +     A  +            |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | A                             +     +  +  +        +     +  +            |             
      Leiomyoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | A                             +     +  +  M        +     +  +            |             
                                            __________________________________________________________________________|             
   Intestine Small                         | A                             +     +  +  +        +     A  +            |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | A                             A     +  +  +        +     A  +            |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | A                             +     +  A  +        +     A  +            |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | A                             +     +  A  +        +     A  +            |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma, Multiple            |                                                                          |             
      Hepatocellular Carcinoma             |                                                                          |             
      Hepatocellular Adenoma               |       X                                               X                  |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                           X              X               |             
      Lymphoma Malignant                   | X                                                                        |             
      Lymphoma Malignant Mixed             |                X                 X                                       |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                     +  +                                 |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +                             +     +  +  +        +     +  +            |             
      Lymphoma Malignant Lymphocytic       |                                           X                              |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | M                             +     +  +  +        +     +  +            |             
                                            __________________________________________________________________________|             
   Stomach                                 | +                             +     +  +  +        +     +  +            |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +                             +     +  +  +        +     +  +            |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +                             +     A  +  +        +     +  +            |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +                             +     +  +  +        +     +  +            |             
      Lymphoma Malignant                   | X                                                                        |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Adenoma                     |                                              X                           |             
      Capsule, Carcinoma                   |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                          X               |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   9                                                               
NTP Experiment-Test: 05074-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  PENTACHLOROPHENOL, DOWICIDE EC7                              Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 14:43:51  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 5| 6| 5| 7| 7| 4| 7| 4| 3| 7| 7| 7| 6|             
                             DAY ON TEST   | 5| 2| 2| 2| 0| 2| 3| 2| 2| 3| 2| 2| 6| 2| 9| 3| 2| 4| 2| 8| 2| 2| 2| 2| 4|             
                                           | 4| 8| 9| 8| 1| 7| 0| 7| 8| 0| 1| 7| 6| 9| 6| 0| 7| 3| 7| 3| 1| 7| 9| 7| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    100 PPM                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pheochromocytoma Malignant           |                                                                          |             
      Pheochromocytoma Benign              |                                  X                                       |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +                          +  +     +  +  +        +     +  +            |             
      Carcinoma                            |                            X                                             |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M                             +     +  +  +        M     +  +            |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +     +                       +     +  +  +        +  +  +  +            |             
      Pars Distalis, Adenoma               |       X                                               X                  |             
      Pars Intermedia, Adenoma             |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +                             +     +  +  +        +     +  +            |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +           +  +  +           +     +  +  +        +     +  +        +  +|             
      Lymphoma Malignant Mixed             |                X                                                         |             
      Periovarian Tissue, Lymphoma         |                                                                          |             
          Malignant Lymphocytic            |                                                          X               |             
      Periovarian Tissue, Lymphoma         |                                                                          |             
          Malignant                        | X                                                                        |             
      Periovarian Tissue, Lymphoma         |                                                                          |             
          Malignant Mixed                  |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +        +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +     +  +   |             
      Lymphoma Malignant Lymphocytic       |                                                          X               |             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                          +               |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | A                             +     +  +  +        +     +  +            |             
      Lymphoma Malignant Lymphocytic       |                                           X                              |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +              +        +     +     +  +  +  +     +     +  +            |             
      Lymphoma Malignant                   | X                                                                        |             
      Axillary, Lymphoma Malignant         |                                                                          |             
          Histiocytic                      |                                                                          |             
      Deep Cervical, Lymphoma Malignant    |                                                                          |             
          Mixed                            |                                                                          |             
      Inguinal, Lymphoma Malignant         |                                                                          |             
          Lymphocytic                      |                                                          X               |             
      Inguinal, Lymphoma Malignant         | X                                                                        |             
      Inguinal, Lymphoma Malignant Mixed   |                                                                          |             
      Lumbar, Lymphoma Malignant           |                                                                          |             
          Histiocytic                      |                                                                          |             
      Lumbar, Lymphoma Malignant           |                                                                          |             
          Lymphocytic                      |                                                          X               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  10                                                               
NTP Experiment-Test: 05074-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  PENTACHLOROPHENOL, DOWICIDE EC7                              Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 14:43:51  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 5| 6| 5| 7| 7| 4| 7| 4| 3| 7| 7| 7| 6|             
                             DAY ON TEST   | 5| 2| 2| 2| 0| 2| 3| 2| 2| 3| 2| 2| 6| 2| 9| 3| 2| 4| 2| 8| 2| 2| 2| 2| 4|             
                                           | 4| 8| 9| 8| 1| 7| 0| 7| 8| 0| 1| 7| 6| 9| 6| 0| 7| 3| 7| 3| 1| 7| 9| 7| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    100 PPM                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Lymphocytic                      |                                                          X               |             
      Mediastinal, Lymphoma Malignant Mixed|                X                                                         |             
      Mesenteric, Lymphoma Malignant       |                                                                          |             
          Histiocytic                      |                                                                          |             
      Mesenteric, Lymphoma Malignant       |                                                                          |             
          Lymphocytic                      |                                                          X               |             
      Mesenteric, Lymphoma Malignant Mixed |                X        X                                                |             
      Pancreatic, Lymphoma Malignant       |                                                                          |             
          Histiocytic                      |                                                                          |             
      Renal, Lymphoma Malignant Histiocytic|                                                                          |             
      Renal, Lymphoma Malignant Lymphocytic|                                                          X               |             
      Renal, Lymphoma Malignant Mixed      |                                              X                           |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M              +              +     +  +  +        +     +  +            |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                          X               |             
      Lymphoma Malignant Mixed             |                X                                                         |             
                                            __________________________________________________________________________|             
   Spleen                                  | +     +     +  +              +  +  +  +  +        +     +  +           +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |       X                                   X              X               |             
      Lymphoma Malignant                   | X                                                                        |             
      Lymphoma Malignant Mixed             |                X                 X                                       |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +                             +     M  M  M        M     +  +            |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant                   | X                                                                        |             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M                             M     +  M  M        +     M  M           +|             
      Adenocarcinoma                       |                                                                         X|             
                                            __________________________________________________________________________|             
   Skin                                    | +                    +        +  +  +  +  +        +  +  +  +        +   |             
      Subcutaneous Tissue, Fibrosarcoma    |                                  X                                       |             
      Subcutaneous Tissue, Sarcoma         |                                                    X                     |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +                             +     +  +  +        +     +  +            |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                    +                     |             
      Sarcoma, Metastatic, Skin            |                                                    X                     |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +                             +     +  +  +        +     +  +            |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  11                                                               
NTP Experiment-Test: 05074-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  PENTACHLOROPHENOL, DOWICIDE EC7                              Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 14:43:51  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 5| 6| 5| 7| 7| 4| 7| 4| 3| 7| 7| 7| 6|             
                             DAY ON TEST   | 5| 2| 2| 2| 0| 2| 3| 2| 2| 3| 2| 2| 6| 2| 9| 3| 2| 4| 2| 8| 2| 2| 2| 2| 4|             
                                           | 4| 8| 9| 8| 1| 7| 0| 7| 8| 0| 1| 7| 6| 9| 6| 0| 7| 3| 7| 3| 1| 7| 9| 7| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    100 PPM                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +                          +     +  +  +        +     +  +            |             
      Alveolar/Bronchiolar Adenoma         | X  X                                                                     |             
      Alveolar/Bronchiolar Adenoma,        |                                                                          |             
          Multiple                         |                                     X                                    |             
      Lymphoma Malignant Lymphocytic       |                                                          X               |             
      Lymphoma Malignant                   | X                                                                        |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +                             +     +  +  +        +     +  +            |             
                                            __________________________________________________________________________|             
   Trachea                                 | +                             +     +  +  +        +     +  +            |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +        +                    +     +  +  M        +     +  +            |             
      Adenoma                              |          X                                                               |             
      Lymphoma Malignant                   | X                                                                        |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +                             +     +  +  +        +     +  +            |             
      Lymphoma Malignant Lymphocytic       |                                           X              X               |             
      Lymphoma Malignant                   | X                                                                        |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                             +            |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | A                             +     +  +  +        +     +  +            |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant                   | X                                                                        |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |       X                                   X              X               |             
      Lymphoma Malignant Mixed             |                X        X        X           X                           |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  12                                                               
NTP Experiment-Test: 05074-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  PENTACHLOROPHENOL, DOWICIDE EC7                              Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 14:43:51  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 4| 5| 5| 7| 6| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 9| 7| 4| 3| 3| 3| 2| 1| 6| 1| 4| 3| 1| 2| 3| 3| 2| 6| 2| 2| 2| 2|            |
                                           | 0| 0| 0| 7| 2| 2| 0| 1| 0| 8| 3| 9| 4| 5| 6| 2| 7| 0| 0| 7| 4| 9| 9| 0| 9|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     A      |
    100 PPM                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |          +  +  +     +                    +                 +            |  14        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |          +  A  +     +                    +                 +            |  11        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |          +  +  +     +     +              +                 +            |  14        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |          +  +  +                          +                 +            |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |          +  +  +           +              +                 +            |  13        |
      Leiomyoma                            |                            X                                             |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |          +  +  +                          +                 +            |  11        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |          +  +  +     +                    +                 +            |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |          +  +  +                          +                 +            |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |          +  +  +                          +                 +            |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |          +  +  +                          +                 +            |  10        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemangiosarcoma, Multiple            |                                                 X                        |          1 |
      Hepatocellular Carcinoma             |                                                                      X   |          1 |
      Hepatocellular Adenoma               |                                                 X                        |          3 |
      Lymphoma Malignant Histiocytic       |                                        X                                 |          1 |
      Lymphoma Malignant Lymphocytic       |                                                 X                        |          3 |
      Lymphoma Malignant                   |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                   X           X     X                       X            |          6 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                X                                                         |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                     +     +                              |   4        |
      Lymphoma Malignant Mixed             |                                     X                                    |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                |    +     +  +  +     +              +     +                 +            |  16        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                     X                       X            |          2 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |          +  +  +     +                    +                 M            |  12        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |          +  +  +     +                    +                 +            |  14        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |          +  +  +     +                    +                 +            |  14        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |          +  +  +     +                    +                 +            |  13        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |          +  +  +     +                    +                 +            |  14        |
      Lymphoma Malignant                   |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Capsule, Adenoma                     |                   X                                                      |          2 |
      Capsule, Carcinoma                   |    X                                                                     |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  13                                                               
NTP Experiment-Test: 05074-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  PENTACHLOROPHENOL, DOWICIDE EC7                              Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 14:43:51  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 4| 5| 5| 7| 6| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 9| 7| 4| 3| 3| 3| 2| 1| 6| 1| 4| 3| 1| 2| 3| 3| 2| 6| 2| 2| 2| 2|            |
                                           | 0| 0| 0| 7| 2| 2| 0| 1| 0| 8| 3| 9| 4| 5| 6| 2| 7| 0| 0| 7| 4| 9| 9| 0| 9|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     A      |
    100 PPM                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|  49        |
      Lymphoma Malignant Histiocytic       |                                        X                                 |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                   X                                                      |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|  49        |
      Pheochromocytoma Malignant           |                   X                                                      |          1 |
      Pheochromocytoma Benign              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +        +  +  +     +                    +                 +            |  16        |
      Carcinoma                            | X                                                                        |          2 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |          M  +  +     +                    +                 +            |  11        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +        +  +  +     M     +              +                 +            |  17        |
      Pars Distalis, Adenoma               |                            X                                             |          3 |
      Pars Intermedia, Adenoma             | X                                                                        |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |          +  +  +     +                    +                 +            |  14        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +        +  +  +     +              +     +  +        +     +        +   |  24        |
      Lymphoma Malignant Mixed             |                                                             X            |          2 |
      Periovarian Tissue, Lymphoma         |                                                                          |            |
          Malignant Lymphocytic            |                                                                          |          1 |
      Periovarian Tissue, Lymphoma         |                                                                          |            |
          Malignant                        |                                                                          |          1 |
      Periovarian Tissue, Lymphoma         |                                                                          |            |
          Malignant Mixed                  |                                     X                                    |          1 |
                                            __________________________________________________________________________|____________|
   Uterus                                  |    +     +  +  +     +  +        +        +  +  +  +  +  +  +  +  +     +|  36        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                             X            |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |          +  +  +     +                    +                 +            |  13        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |          +  +  +  +  +        +     +  +  +  +              +  +         |  23        |
      Lymphoma Malignant                   |                                                                          |          1 |
      Axillary, Lymphoma Malignant         |                                                                          |            |
          Histiocytic                      |                                        X                                 |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  14                                                               
NTP Experiment-Test: 05074-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  PENTACHLOROPHENOL, DOWICIDE EC7                              Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 14:43:51  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 4| 5| 5| 7| 6| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 9| 7| 4| 3| 3| 3| 2| 1| 6| 1| 4| 3| 1| 2| 3| 3| 2| 6| 2| 2| 2| 2|            |
                                           | 0| 0| 0| 7| 2| 2| 0| 1| 0| 8| 3| 9| 4| 5| 6| 2| 7| 0| 0| 7| 4| 9| 9| 0| 9|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     A      |
    100 PPM                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Deep Cervical, Lymphoma Malignant    |                                                                          |            |
          Mixed                            |                               X                                          |          1 |
      Inguinal, Lymphoma Malignant         |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
      Inguinal, Lymphoma Malignant         |                                                                          |          1 |
      Inguinal, Lymphoma Malignant Mixed   |                               X                             X            |          2 |
      Lumbar, Lymphoma Malignant           |                                                                          |            |
          Histiocytic                      |                                        X                                 |          1 |
      Lumbar, Lymphoma Malignant           |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
      Mediastinal, Lymphoma Malignant      |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
      Mediastinal, Lymphoma Malignant Mixed|                   X           X     X                                    |          4 |
      Mesenteric, Lymphoma Malignant       |                                                                          |            |
          Histiocytic                      |                                        X                                 |          1 |
      Mesenteric, Lymphoma Malignant       |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
      Mesenteric, Lymphoma Malignant Mixed |                   X           X     X        X                 X         |          7 |
      Pancreatic, Lymphoma Malignant       |                                                                          |            |
          Histiocytic                      |                                        X                                 |          1 |
      Renal, Lymphoma Malignant Histiocytic|                                        X                                 |          1 |
      Renal, Lymphoma Malignant Lymphocytic|                                                                          |          1 |
      Renal, Lymphoma Malignant Mixed      |                   X           X     X        X              X            |          6 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |          +  +  +  +  +        +        +  +                 M            |  16        |
      Lymphoma Malignant Histiocytic       |                                        X                                 |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                   X           X                                          |          3 |
                                            __________________________________________________________________________|____________|
   Spleen                                  |          +  +  +  +  +  +     +     +  +  +  +              +        +   |  26        |
      Lymphoma Malignant Histiocytic       |                                        X                                 |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          3 |
      Lymphoma Malignant                   |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                   X     X     X              X              X            |          7 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                X                                                         |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  |          M  +  M     +                 +  +                 +            |   9        |
      Lymphoma Malignant Histiocytic       |                                        X                                 |          1 |
      Lymphoma Malignant                   |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                             X            |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  15                                                               
NTP Experiment-Test: 05074-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  PENTACHLOROPHENOL, DOWICIDE EC7                              Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 14:43:51  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 4| 5| 5| 7| 6| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 9| 7| 4| 3| 3| 3| 2| 1| 6| 1| 4| 3| 1| 2| 3| 3| 2| 6| 2| 2| 2| 2|            |
                                           | 0| 0| 0| 7| 2| 2| 0| 1| 0| 8| 3| 9| 4| 5| 6| 2| 7| 0| 0| 7| 4| 9| 9| 0| 9|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     A      |
    100 PPM                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |          +  +  M     M                    +                 M            |   6        |
      Adenocarcinoma                       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    |          +  +  +     +                    +     +  +  +     +  +         |  22        |
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |          1 |
      Subcutaneous Tissue, Sarcoma         |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |          +  +  +     +                    +                 +            |  14        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
      Sarcoma, Metastatic, Skin            |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |          +  +  +     +                    +                 +            |  14        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |          +  +  +     +                    +                 +            |  15        |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          2 |
      Alveolar/Bronchiolar Adenoma,        |                                                                          |            |
          Multiple                         |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant                   |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                             X            |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                X                                                         |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    |          +  +  +     +                    +                 +            |  14        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |          +  +  +     +                    +                 +            |  14        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                +                                                         |   1        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |          +  +  M     M                    +                 +            |  12        |
      Adenoma                              |                                                                          |          1 |
      Lymphoma Malignant                   |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |          +  +  +  +  +                    +                 +            |  15        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          2 |
      Lymphoma Malignant                   |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                   X                                         X            |          2 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  16                                                               
NTP Experiment-Test: 05074-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  PENTACHLOROPHENOL, DOWICIDE EC7                              Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 14:43:51  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 4| 5| 5| 7| 6| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 9| 7| 4| 3| 3| 3| 2| 1| 6| 1| 4| 3| 1| 2| 3| 3| 2| 6| 2| 2| 2| 2|            |
                                           | 0| 0| 0| 7| 2| 2| 0| 1| 0| 8| 3| 9| 4| 5| 6| 2| 7| 0| 0| 7| 4| 9| 9| 0| 9|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     A      |
    100 PPM                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Urethra                                 |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |          +  +  M     +                    +                 +            |  12        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant                   |                                                                          |          1 |
      Lymphoma Malignant Histiocytic       |                                        X                                 |          1 |
      Lymphoma Malignant Lymphocytic       |                                                 X                        |          4 |
      Lymphoma Malignant Mixed             |                   X     X     X     X        X              X  X         |         11 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                X                                                         |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  17                                                               
NTP Experiment-Test: 05074-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  PENTACHLOROPHENOL, DOWICIDE EC7                              Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 14:43:51  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 2| 2| 2| 2| 3| 9| 2| 1| 2| 2| 2| 2| 3| 0| 3| 3| 2| 8| 3| 2| 2| 2| 2| 2|             
                                           | 0| 8| 8| 8| 7| 0| 9| 9| 1| 9| 8| 7| 7| 5| 6| 0| 0| 9| 9| 0| 7| 9| 9| 8| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    200 PPM                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |                                        +                                 |             
                                            __________________________________________________________________________|             
   Gallbladder                             |                                        A                                 |             
                                            __________________________________________________________________________|             
   Intestine Large                         |                                        +                                 |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |                                        +                                 |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                                        +                                 |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |                                        +                                 |             
                                            __________________________________________________________________________|             
   Intestine Small                         |                                        +                                 |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |                                        +                                 |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |                                        +                                 |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                                        +                                 |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosarcoma, Metastatic, Skin       |                                                             X            |             
      Hemangiosarcoma, Multiple            |                   X                                                      |             
      Hemangiosarcoma, Metastatic, Spleen  |                         X                                                |             
      Hepatocellular Adenoma               |                                     X              X              X      |             
      Hepatocellular Adenoma, Multiple     |                                                 X                        |             
      Lymphoma Malignant Histiocytic       |                                           X                              |             
      Lymphoma Malignant Lymphocytic       |                                                                         X|             
      Lymphoma Malignant Mixed             |                                                 X                        |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |                                        +                                 |             
      Hemangiosarcoma, Metastatic, Spleen  |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |                                        M                                 |             
                                            __________________________________________________________________________|             
   Stomach                                 |                                        +                                 |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |                                        +                                 |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |                                        +                                 |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
      Mucosa, Dorsal, Squamous Cell        |                                                                          |             
          Carcinoma                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |                                        +                                 |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pheochromocytoma Benign              |                            X                    X                        |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |                                        +                                 |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |                                        M                                 |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |                +     I                 +        +           +  +         |             
      Pars Distalis, Adenoma               |                X                                X              X         |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |                                        +                                 |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  18                                                               
NTP Experiment-Test: 05074-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  PENTACHLOROPHENOL, DOWICIDE EC7                              Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 14:43:51  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 2| 2| 2| 2| 3| 9| 2| 1| 2| 2| 2| 2| 3| 0| 3| 3| 2| 8| 3| 2| 2| 2| 2| 2|             
                                           | 0| 8| 8| 8| 7| 0| 9| 9| 1| 9| 8| 7| 7| 5| 6| 0| 0| 9| 9| 0| 7| 9| 9| 8| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    200 PPM                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   |          +                    +        +  +     +  +  +           +     +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Periovarian Tissue, Lymphoma         |                                                                          |             
          Malignant Mixed                  |                                                    X                     |             
                                            __________________________________________________________________________|             
   Uterus                                  | +     +  +  +  +     +  +  +  +  +  +  +     +  +     +  +  +  +  +  +  +|             
      Leiomyoma                            |                                                       X                  |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |                                        +                                 |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                +        +              M        +  +                    +|             
      Lumbar, Lymphoma Malignant           |                                                                          |             
          Lymphocytic                      |                                                                         X|             
      Lumbar, Lymphoma Malignant Mixed     |                                                    X                     |             
      Mesenteric, Lymphoma Malignant Mixed |                                                 X  X                     |             
      Renal, Lymphoma Malignant Histiocytic|                                                                          |             
      Renal, Lymphoma Malignant Mixed      |                                                    X                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |                                        M        +                        |             
      Lymphoma Malignant Mixed             |                                                 X                        |             
                                            __________________________________________________________________________|             
   Spleen                                  | +                 +     +           +  +  +        +        +            |             
      Hemangiosarcoma                      |                         X                                                |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                    X        X            |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        | X                                                                        |             
                                            __________________________________________________________________________|             
   Thymus                                  |                                        +  +                              |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |                                     +  +                                 |             
      Adenocarcinoma                       |                                     X                                    |             
                                            __________________________________________________________________________|             
   Skin                                    |                +     +                 +        +        +  +           +|             
      Subcutaneous Tissue, Fibrosarcoma    |                                                             X            |             
      Subcutaneous Tissue, Hemangiosarcoma |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |                                        +                                 |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |                                        +                                 |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  19                                                               
NTP Experiment-Test: 05074-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  PENTACHLOROPHENOL, DOWICIDE EC7                              Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 14:43:51  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 2| 2| 2| 2| 3| 9| 2| 1| 2| 2| 2| 2| 3| 0| 3| 3| 2| 8| 3| 2| 2| 2| 2| 2|             
                                           | 0| 8| 8| 8| 7| 0| 9| 9| 1| 9| 8| 7| 7| 5| 6| 0| 0| 9| 9| 0| 7| 9| 9| 8| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    200 PPM                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |                                        +                                 |             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Mediastinum, Lymphoma Malignant Mixed|                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |                                        +                                 |             
                                            __________________________________________________________________________|             
   Trachea                                 |                                        +                                 |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                        M                                 |             
      Adenoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |                                        +           +              +      |             
      Lymphoma Malignant Mixed             |                                                    X              X      |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |                                        +                                 |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                           X                              |             
      Lymphoma Malignant Lymphocytic       |                                                    X        X           X|             
      Lymphoma Malignant Mixed             |                                                 X  X              X      |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        | X                                                                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  20                                                               
NTP Experiment-Test: 05074-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  PENTACHLOROPHENOL, DOWICIDE EC7                              Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 14:43:51  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 2| 0| 3| 3| 3| 3| 2| 1| 2| 3| 2| 3| 2| 2| 2| 2| 2| 2| 4| 3| 2| 2| 2| 2| 1|            |
                                           | 9| 7| 0| 0| 0| 6| 7| 4| 7| 0| 7| 1| 7| 8| 8| 9| 9| 6| 8| 0| 9| 7| 7| 8| 0|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|     A      |
    200 PPM                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |                +     M           +                 +                     |   4        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |                +     A           +                 +                     |   3        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |                +     +           +                 +  A                  |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                +     A           +                    A                  |   3        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                +     +           +                    A                  |   4        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                +     +           +                    A                  |   4        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                +     A           +                 +  A                  |   4        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                +     A           +                    A                  |   3        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                +     A           +                    A                  |   3        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                +     A           +                    A                  |   3        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  49        |
      Fibrosarcoma, Metastatic, Skin       |                                                                          |          1 |
      Hemangiosarcoma, Multiple            |                                                                          |          1 |
      Hemangiosarcoma, Metastatic, Spleen  |       X                                                                  |          2 |
      Hepatocellular Adenoma               |       X                                                           X      |          5 |
      Hepatocellular Adenoma, Multiple     |                                                                          |          1 |
      Lymphoma Malignant Histiocytic       |                      X                                                   |          2 |
      Lymphoma Malignant Lymphocytic       |                                                                   X      |          2 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                +                                                         |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                |       +        +     +           +                 +        +            |   7        |
      Hemangiosarcoma, Metastatic, Spleen  |       X                                                                  |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                +     M           +                 +                     |   3        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |                +     +           +                 +  A                  |   5        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                +     +           +                 +  A                  |   5        |
      Lymphoma Malignant Histiocytic       |                      X                                                   |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                +     +           +                 +  A                  |   5        |
                                            __________________________________________________________________________|____________|
   Tongue                                  |       +                                                                  |   1        |
      Mucosa, Dorsal, Squamous Cell        |                                                                          |            |
          Carcinoma                        |       X                                                                  |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |                +     +           +                 +                     |   5        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A|  47        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A|  47        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  A  +  +  +  +  +  A|  46        |
      Pheochromocytoma Benign              |                                                                          |          2 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  21                                                               
NTP Experiment-Test: 05074-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  PENTACHLOROPHENOL, DOWICIDE EC7                              Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 14:43:51  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 2| 0| 3| 3| 3| 3| 2| 1| 2| 3| 2| 3| 2| 2| 2| 2| 2| 2| 4| 3| 2| 2| 2| 2| 1|            |
                                           | 9| 7| 0| 0| 0| 6| 7| 4| 7| 0| 7| 1| 7| 8| 8| 9| 9| 6| 8| 0| 9| 7| 7| 8| 0|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|     A      |
    200 PPM                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                +     +           +                 +                     |   5        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                +     M           +                 +                     |   3        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |                +     M           +     +           +                    A|   9        |
      Pars Distalis, Adenoma               |                                        X                                 |          4 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                +     M           +                 +                     |   4        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +           +  +     +           +        +        +                 +   |  17        |
      Lymphoma Malignant Histiocytic       |                      X                                                   |          1 |
      Periovarian Tissue, Lymphoma         |                                                                          |            |
          Malignant Mixed                  |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +     +  +  +  +  +  +  +  +     +  +  +  +  +     +     +  +  +  +  +   |  41        |
      Leiomyoma                            |                                                                          |          1 |
      Lymphoma Malignant Histiocytic       |                      X                                                   |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                +     +           +                 +                     |   5        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +     +        +     +           +                 +                     |  11        |
      Lumbar, Lymphoma Malignant           |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
      Lumbar, Lymphoma Malignant Mixed     |                                                                          |          1 |
      Mesenteric, Lymphoma Malignant Mixed | X                                                                        |          3 |
      Renal, Lymphoma Malignant Histiocytic|                      X                                                   |          1 |
      Renal, Lymphoma Malignant Mixed      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                +                 +                 +                     |   4        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +     +     +  +     A        +  +     +        +  +                     |  17        |
      Hemangiosarcoma                      |       X                                                                  |          2 |
      Lymphoma Malignant Histiocytic       |                                                 X                        |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          2 |
      Lymphoma Malignant Mixed             | X           X                 X                                          |          3 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  |                M     +           +                 +                     |   5        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  22                                                               
NTP Experiment-Test: 05074-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  PENTACHLOROPHENOL, DOWICIDE EC7                              Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 14:43:51  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 2| 0| 3| 3| 3| 3| 2| 1| 2| 3| 2| 3| 2| 2| 2| 2| 2| 2| 4| 3| 2| 2| 2| 2| 1|            |
                                           | 9| 7| 0| 0| 0| 6| 7| 4| 7| 0| 7| 1| 7| 8| 8| 9| 9| 6| 8| 0| 9| 7| 7| 8| 0|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|     A      |
    200 PPM                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                +     +           +                 +                    +|   7        |
      Adenocarcinoma                       |                                                                         X|          2 |
                                            __________________________________________________________________________|____________|
   Skin                                    |       +        +     +        +  +  +     +  +  +  +     +               |  18        |
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |          1 |
      Subcutaneous Tissue, Hemangiosarcoma |       X                                                                  |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                +     +           +                 +                     |   5        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                +     +           +                 +                     |   5        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +              +     +           +                 +                     |   6        |
      Alveolar/Bronchiolar Adenoma         |                X                                                         |          1 |
      Lymphoma Malignant Histiocytic       |                      X                                                   |          1 |
      Mediastinum, Lymphoma Malignant Mixed| X                                                                        |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    |                +     +           +                 +                     |   5        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |                +     M           +                 +                     |   4        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                +     +           M           +     +                     |   4        |
      Adenoma                              |                                              X                           |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +              +     +           +                 +                     |   8        |
      Lymphoma Malignant Mixed             | X                                                                        |          3 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                +     +           +                 +                     |   5        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|  49        |
      Lymphoma Malignant Histiocytic       |                      X                          X                        |          3 |
      Lymphoma Malignant Lymphocytic       |                                                                   X      |          4 |
      Lymphoma Malignant Mixed             | X           X                 X                                          |          6 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  23                                                               
NTP Experiment-Test: 05074-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  PENTACHLOROPHENOL, DOWICIDE EC7                              Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 14:43:51  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 0| 2| 2| 2| 2| 3| 3| 2| 2| 2| 2| 2| 6| 2| 2| 2| 2| 2| 2| 7| 2| 8| 2| 2| 2|             
                                           | 2| 9| 9| 8| 7| 0| 0| 7| 7| 8| 7| 9| 8| 9| 9| 7| 9| 7| 8| 0| 9| 9| 9| 8| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    600 PPM                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | A  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Peyer's Patch, Lymphoma Malignant    |                                                                          |             
          Mixed                            |                                              X                           |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangioma                           |                         X                                                |             
      Hemangiosarcoma                      |                X                                               X         |             
      Hemangiosarcoma, Multiple            |                            X                                             |             
      Hepatocellular Carcinoma             |                                                 X                        |             
      Hepatocellular Adenoma               |                               X  X  X                                    |             
      Hepatocellular Adenoma, Multiple     |             X  X  X  X  X  X           X  X     X           X     X  X   |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                       X                  |             
                                            __________________________________________________________________________|             
   Mesentery                               |       +                                                                  |             
      Hemangiosarcoma                      |                                                                          |             
      Myxosarcoma, Metastatic, Skin        |       X                                                                  |             
                                            __________________________________________________________________________|             
   Pancreas                                | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                         X                                                |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                             X            |             
      Lymphoma Malignant Mixed             |                                              X                           |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                             X            |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma, Metastatic, Spleen  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pheochromocytoma Malignant           |                                                                          |             
      Pheochromocytoma Benign              |          X  X              X                 X           X     X         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  24                                                               
NTP Experiment-Test: 05074-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  PENTACHLOROPHENOL, DOWICIDE EC7                              Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 14:43:51  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 0| 2| 2| 2| 2| 3| 3| 2| 2| 2| 2| 2| 6| 2| 2| 2| 2| 2| 2| 7| 2| 8| 2| 2| 2|             
                                           | 2| 9| 9| 8| 7| 0| 0| 7| 7| 8| 7| 9| 8| 9| 9| 7| 9| 7| 8| 0| 9| 9| 9| 8| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    600 PPM                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Bilateral, Pheochromocytoma Benign   |                   X  X  X     X        X  X     X     X     X     X  X  X|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | M  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               |          X     X        X        X              X                        |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Adenoma             |                                                          X        X      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Periovarian Tissue, Lymphoma         |                                                                          |             
          Malignant Histiocytic            |                                                                          |             
      Periovarian Tissue, Lymphoma         |                                                                          |             
          Malignant Lymphocytic            |                                                                          |             
      Periovarian Tissue, Lymphoma         |                                                                          |             
          Malignant Mixed                  |                                           X  X                           |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leiomyoma                            |                                              X                           |             
      Leiomyosarcoma                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                                          |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                          X               |             
      Deep Cervical, Lymphoma Malignant    |                                                                          |             
          Histiocytic                      |                                                                          |             
      Lumbar, Lymphoma Malignant           |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Histiocytic                      |                                                                          |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Mediastinal, Lymphoma Malignant Mixed|                                           X                              |             
      Mesenteric, Lymphoma Malignant       |                                                                          |             
          Lymphocytic                      |             X        X                                      X            |             
      Mesenteric, Lymphoma Malignant Mixed |                                           X                              |             
      Pancreatic, Lymphoma Malignant       |                                                                          |             
          Histiocytic                      |                                                                          |             
      Pancreatic, Lymphoma Malignant       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  25                                                               
NTP Experiment-Test: 05074-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  PENTACHLOROPHENOL, DOWICIDE EC7                              Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 14:43:51  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 0| 2| 2| 2| 2| 3| 3| 2| 2| 2| 2| 2| 6| 2| 2| 2| 2| 2| 2| 7| 2| 8| 2| 2| 2|             
                                           | 2| 9| 9| 8| 7| 0| 0| 7| 7| 8| 7| 9| 8| 9| 9| 7| 9| 7| 8| 0| 9| 9| 9| 8| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    600 PPM                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
          Lymphocytic                      |                                                       X                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |             X        X  X                             X  X  X            |             
      Lymphoma Malignant Mixed             |                                           X  X                           |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                                          |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |             X        X  X                             X     X            |             
      Lymphoma Malignant Mixed             |                                           X  X                           |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                           X  X                           |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +|             
      Adenocarcinoma                       |                      X              X  X                                 |             
                                            __________________________________________________________________________|             
   Skin                                    | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Myxosarcoma     |       X                                                                  |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma, Metastatic, Mammary  |                                                                          |             
          Gland                            |                                                                          |             
      Alveolar/Bronchiolar Adenoma         |    X                                                                     |             
      Alveolar/Bronchiolar Carcinoma       |                                  X                                       |             
      Hepatocellular Carcinoma, Metastatic |                                                 X                        |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |             X        X                                                   |             
      Lymphoma Malignant Mixed             |                                              X                           |             
      Mediastinum, Lymphoma Malignant Mixed|                                           X                              |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | A  +  +  +  M  M  M  M  +  +  +  +  +  +  M  M  M  M  M  M  M  +  M  +  +|             
      Adenoma                              |    X  X                                                                  |             
      Lymphoma Malignant Lymphocytic       |                         X                                                |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  26                                                               
NTP Experiment-Test: 05074-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  PENTACHLOROPHENOL, DOWICIDE EC7                              Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 14:43:51  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 0| 2| 2| 2| 2| 3| 3| 2| 2| 2| 2| 2| 6| 2| 2| 2| 2| 2| 2| 7| 2| 8| 2| 2| 2|             
                                           | 2| 9| 9| 8| 7| 0| 0| 7| 7| 8| 7| 9| 8| 9| 9| 7| 9| 7| 8| 0| 9| 9| 9| 8| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    600 PPM                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |             X                                         X                  |             
      Lymphoma Malignant Mixed             |                                              X                           |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |             X                                         X                  |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |             X        X  X                             X  X  X            |             
      Lymphoma Malignant Mixed             |                                           X  X                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  27                                                               
NTP Experiment-Test: 05074-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  PENTACHLOROPHENOL, DOWICIDE EC7                              Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 14:43:51  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 5| 5| 5| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4|            |
                             DAY ON TEST   | 2| 2| 3| 2| 2| 5| 1| 2| 2| 2| 1| 2| 5| 2| 2| 2| 3| 3| 3| 3| 1| 2| 2| 2| 8|            |
                                           | 9| 7| 0| 7| 8| 5| 6| 8| 8| 8| 1| 9| 3| 9| 8| 9| 0| 0| 0| 0| 2| 8| 8| 7| 5|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|     A      |
    600 PPM                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  A  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  47        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  A  A  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +   |  42        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  45        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  A  A  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +   |  44        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  45        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  47        |
      Peyer's Patch, Lymphoma Malignant    |                                                                          |            |
          Mixed                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  48        |
      Hemangioma                           |                                                                          |          1 |
      Hemangiosarcoma                      |          X              X                                                |          4 |
      Hemangiosarcoma, Multiple            |       X                       X                             X            |          4 |
      Hepatocellular Carcinoma             |       X                                                                  |          2 |
      Hepatocellular Adenoma               |                         X              X  X        X           X  X      |          9 |
      Hepatocellular Adenoma, Multiple     |    X     X           X           X           X  X     X  X           X   |         21 |
      Lymphoma Malignant Histiocytic       |                                     X                                    |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |       +                                                                  |   2        |
      Hemangiosarcoma                      |       X                                                                  |          1 |
      Myxosarcoma, Metastatic, Skin        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  46        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  46        |
      Lymphoma Malignant Lymphocytic       |                                                                   X      |          2 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  47        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  47        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  47        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  48        |
      Hemangiosarcoma, Metastatic, Spleen  |                                                             X            |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  28                                                               
NTP Experiment-Test: 05074-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  PENTACHLOROPHENOL, DOWICIDE EC7                              Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 14:43:51  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 5| 5| 5| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4|            |
                             DAY ON TEST   | 2| 2| 3| 2| 2| 5| 1| 2| 2| 2| 1| 2| 5| 2| 2| 2| 3| 3| 3| 3| 1| 2| 2| 2| 8|            |
                                           | 9| 7| 0| 7| 8| 5| 6| 8| 8| 8| 1| 9| 3| 9| 8| 9| 0| 0| 0| 0| 2| 8| 8| 7| 5|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|     A      |
    600 PPM                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Pheochromocytoma Malignant           |                                              X                           |          1 |
      Pheochromocytoma Benign              | X                          X                 X                           |          9 |
      Bilateral, Pheochromocytoma Benign   |    X  X  X     X     X  X     X  X     X        X  X  X  X  X  X  X  X   |         29 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  46        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  M  M  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +   |  44        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  M  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  44        |
      Pars Distalis, Adenoma               |                            X                                             |          6 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  A  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +   |  46        |
      Follicular Cell, Adenoma             | X                                                                        |          3 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  48        |
      Periovarian Tissue, Lymphoma         |                                                                          |            |
          Malignant Histiocytic            |                                           X                              |          1 |
      Periovarian Tissue, Lymphoma         |                                                                          |            |
          Malignant Lymphocytic            |                                                                      X   |          1 |
      Periovarian Tissue, Lymphoma         |                                                                          |            |
          Malignant Mixed                  |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  47        |
      Leiomyoma                            |                                                                          |          1 |
      Leiomyosarcoma                       |                                                    X                     |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  48        |
      Hemangiosarcoma                      |                                                             X            |          1 |
      Lymphoma Malignant Histiocytic       |                                     X                                    |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  M  +  +  M  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  44        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Deep Cervical, Lymphoma Malignant    |                                                                          |            |
          Histiocytic                      |                                     X                                    |          1 |
      Lumbar, Lymphoma Malignant           |                                                                          |            |
          Lymphocytic                      |                                                          X               |          1 |
      Mediastinal, Lymphoma Malignant      |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  29                                                               
NTP Experiment-Test: 05074-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  PENTACHLOROPHENOL, DOWICIDE EC7                              Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 14:43:51  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 5| 5| 5| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4|            |
                             DAY ON TEST   | 2| 2| 3| 2| 2| 5| 1| 2| 2| 2| 1| 2| 5| 2| 2| 2| 3| 3| 3| 3| 1| 2| 2| 2| 8|            |
                                           | 9| 7| 0| 7| 8| 5| 6| 8| 8| 8| 1| 9| 3| 9| 8| 9| 0| 0| 0| 0| 2| 8| 8| 7| 5|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|     A      |
    600 PPM                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
          Histiocytic                      |                                     X     X                              |          2 |
      Mediastinal, Lymphoma Malignant      |                                                                          |            |
          Lymphocytic                      |                                              X           X               |          2 |
      Mediastinal, Lymphoma Malignant Mixed|                                                                          |          1 |
      Mesenteric, Lymphoma Malignant       |                                                                          |            |
          Lymphocytic                      |                                                                   X  X   |          5 |
      Mesenteric, Lymphoma Malignant Mixed |                                                                          |          1 |
      Pancreatic, Lymphoma Malignant       |                                                                          |            |
          Histiocytic                      |                                     X                                    |          1 |
      Pancreatic, Lymphoma Malignant       |                                                                          |            |
          Lymphocytic                      |                                                                   X      |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  M  +  +  M  A  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M   |  42        |
      Lymphoma Malignant Histiocytic       |                                     X     X                              |          2 |
      Lymphoma Malignant Lymphocytic       |                                                       X  X        X      |          9 |
      Lymphoma Malignant Mixed             | X                                                                        |          3 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  47        |
      Hemangiosarcoma                      |                               X                             X            |          2 |
      Lymphoma Malignant Histiocytic       |                                     X     X                              |          2 |
      Lymphoma Malignant Lymphocytic       |                                              X        X  X        X  X   |         10 |
      Lymphoma Malignant Mixed             | X                                                                        |          3 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  M  M  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +   |  43        |
      Lymphoma Malignant Lymphocytic       |                                              X                       X   |          2 |
      Lymphoma Malignant Mixed             | X                                                                        |          3 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  +  +  +  +  M  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +   |  40        |
      Adenocarcinoma                       |             X                                                            |          4 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  46        |
      Subcutaneous Tissue, Myxosarcoma     |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  47        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  48        |
      Adenocarcinoma, Metastatic, Mammary  |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  30                                                               
NTP Experiment-Test: 05074-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  PENTACHLOROPHENOL, DOWICIDE EC7                              Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 14:43:51  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 5| 5| 5| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4|            |
                             DAY ON TEST   | 2| 2| 3| 2| 2| 5| 1| 2| 2| 2| 1| 2| 5| 2| 2| 2| 3| 3| 3| 3| 1| 2| 2| 2| 8|            |
                                           | 9| 7| 0| 7| 8| 5| 6| 8| 8| 8| 1| 9| 3| 9| 8| 9| 0| 0| 0| 0| 2| 8| 8| 7| 5|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|     A      |
    600 PPM                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
          Gland                            |             X                                                            |          1 |
      Alveolar/Bronchiolar Adenoma         |                                                             X            |          2 |
      Alveolar/Bronchiolar Carcinoma       |                                                                          |          1 |
      Hepatocellular Carcinoma, Metastatic |                                                                          |          1 |
      Lymphoma Malignant Histiocytic       |                                     X                                    |          1 |
      Lymphoma Malignant Lymphocytic       |                                              X        X  X               |          5 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Mediastinum, Lymphoma Malignant Mixed|                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  48        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  A  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  46        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +  M  M  M  +  +  M  M  +  M  +  M  +  M  +  M  M  +  M  +  +  M  M  +   |  23        |
      Adenoma                              |                                                          X               |          3 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  48        |
      Lymphoma Malignant Histiocytic       |                                     X                                    |          1 |
      Lymphoma Malignant Lymphocytic       |                                                       X           X      |          4 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +   |  47        |
      Lymphoma Malignant Lymphocytic       |                                                       X           X      |          4 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Lymphoma Malignant Histiocytic       |                                     X     X                              |          2 |
      Lymphoma Malignant Lymphocytic       |                                              X        X  X        X  X   |         11 |
      Lymphoma Malignant Mixed             | X                                                                        |          3 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  31                                                               
NTP Experiment-Test: 05074-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  PENTACHLOROPHENOL, DOWICIDE EC7                              Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 14:43:51  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 4| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 2| 7| 4| 1|             
                             DAY ON TEST   | 2| 2| 2| 3| 2| 5| 2| 9| 2| 2| 2| 3| 2| 2| 2| 2| 8| 3| 2| 2| 2| 2| 1| 7| 9|             
                                           | 8| 7| 9| 0| 7| 4| 9| 8| 9| 9| 9| 0| 7| 9| 9| 9| 1| 0| 9| 8| 7| 4| 0| 1| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    0 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  A  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  A|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  A|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangioma                           | X                                                                        |             
      Hepatocellular Carcinoma             |          X                                                               |             
      Hepatocellular Adenoma               |                                           X  X     X     X               |             
      Lymphoma Malignant Histiocytic       |                                                                   X      |             
      Lymphoma Malignant Lymphocytic       |                                     X                                    |             
      Lymphoma Malignant Mixed             |          X                                                               |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                     X                                    |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                     X                                    |             
      Lymphoma Malignant Mixed             |                         X                                                |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                     X                                    |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                   X      |             
      Lymphoma Malignant Lymphocytic       |                                     X                                    |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Lymphoma Malignant Mixed    |          X                                                               |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              | X                                                                        |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pheochromocytoma Malignant           |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  +  +  +  +  M  +  +  +  +  M  M  M  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  M  +  +  M  +  I  +  +  +  +  +  +  +  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  32                                                               
NTP Experiment-Test: 05074-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  PENTACHLOROPHENOL, DOWICIDE EC7                              Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 14:43:51  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 4| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 2| 7| 4| 1|             
                             DAY ON TEST   | 2| 2| 2| 3| 2| 5| 2| 9| 2| 2| 2| 3| 2| 2| 2| 2| 8| 3| 2| 2| 2| 2| 1| 7| 9|             
                                           | 8| 7| 9| 0| 7| 4| 9| 8| 9| 9| 9| 0| 7| 9| 9| 9| 1| 0| 9| 8| 7| 4| 0| 1| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    0 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                     X                                    |             
                                            __________________________________________________________________________|             
   Penis                                   |                +     +                                         +        +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                +     +                                                   |             
                                            __________________________________________________________________________|             
   Prostate                                |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                                                             +            |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |    +                          +                       +                  |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femoral, Lymphoma Malignant          |                                                                          |             
          Lymphocytic                      |                                     X                                    |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +|             
      Bronchial, Lymphoma Malignant        |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Lumbar, Lymphoma Malignant Mixed     |          X              X                                                |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Histiocytic                      |                                                                   X      |             
      Mediastinal, Lymphoma Malignant Mixed|          X              X                                                |             
      Mesenteric, Lymphoma Malignant       |                                                                          |             
          Histiocytic                      |                                                                   X      |             
      Mesenteric, Lymphoma Malignant Mixed |          X                                                               |             
      Renal, Lymphoma Malignant Mixed      |          X                                                               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                   X      |             
      Lymphoma Malignant Lymphocytic       |                                     X                                    |             
      Lymphoma Malignant Mixed             |          X              X                                                |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                   X      |             
      Lymphoma Malignant Lymphocytic       |                                     X                                    |             
      Lymphoma Malignant Mixed             |          X              X                                                |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  M  +  +  +  M  +  +  +  +  M  +  I  +  M     M  M  +  M  M  M  +|             
      Lymphoma Malignant Mixed             |                         X                                                |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +|             
      Subcutaneous Tissue, Fibrosarcoma    |    X                                            X     X                  |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  33                                                               
NTP Experiment-Test: 05074-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  PENTACHLOROPHENOL, DOWICIDE EC7                              Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 14:43:51  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 4| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 2| 7| 4| 1|             
                             DAY ON TEST   | 2| 2| 2| 3| 2| 5| 2| 9| 2| 2| 2| 3| 2| 2| 2| 2| 8| 3| 2| 2| 2| 2| 1| 7| 9|             
                                           | 8| 7| 9| 0| 7| 4| 9| 8| 9| 9| 9| 0| 7| 9| 9| 9| 1| 0| 9| 8| 7| 4| 0| 1| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    0 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |       X     X                 X                                   X      |             
      Fibrosarcoma, Metastatic, Skin       |    X                                                                     |             
      Lymphoma Malignant Histiocytic       |                                                                   X      |             
      Lymphoma Malignant Lymphocytic       |                                     X                                    |             
      Lymphoma Malignant Mixed             |                         X                                                |             
      Pheochromocytoma Malignant,          |                                                                          |             
          Metastatic, Adrenal Gland        |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  M  +  +  +  +  M  +  +  +  +  M  +  +  M  M  +  +  +  +  +  +  +  +  M|             
      Adenoma                              |       X                                                  X               |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                     X                                    |             
      Lymphoma Malignant Mixed             |          X              X                                                |             
                                            __________________________________________________________________________|             
   Urethra                                 |                +                                                        +|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +|             
      Lymphoma Malignant Lymphocytic       |                                     X                                    |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                   X      |             
      Lymphoma Malignant Lymphocytic       |                                     X                                    |             
      Lymphoma Malignant Mixed             |          X              X                                                |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  34                                                               
NTP Experiment-Test: 05074-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  PENTACHLOROPHENOL, DOWICIDE EC7                              Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 14:43:51  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 7| 5| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 6| 0| 2| 2| 2| 2| 2| 2| 2|                                            |            |
                                           | 0| 8| 5| 9| 8| 8| 8| 9| 9| 7|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|                                            |     A      |
    0 PPM                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|                                            |     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  35        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  A  +  +  +  +  +  +  +  +                                             |  30        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +                                             |  34        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  32        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  34        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  M  +  +  +  +  +  +  +  +                                             |  31        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +                                             |  33        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  M  +  +  +  +  +  +  +  +                                             |  31        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  M  +  +  +  +  +  +  +  +                                             |  30        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  32        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  35        |
      Hemangioma                           |                                                                          |          1 |
      Hepatocellular Carcinoma             |                                                                          |          1 |
      Hepatocellular Adenoma               |          X                                                               |          5 |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  M  +  +  +  +  +  +  +  +                                             |  34        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  35        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  M  +  +  +  +  +  +  +  +                                             |  33        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  M  +  +  +  +  +  +  +  +                                             |  33        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  M  +  +  +  +  +  +  +  +                                             |  33        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  35        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  A  +  +  +  +  +  +  +  +                                             |  34        |
      Capsule, Lymphoma Malignant Mixed    |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  A  +  +  +  +  +  +  +  +                                             |  34        |
      Adenoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  A  +  +  +  +  +  +  +  +                                             |  34        |
      Pheochromocytoma Malignant           | X                                                                        |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  35                                                               
NTP Experiment-Test: 05074-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  PENTACHLOROPHENOL, DOWICIDE EC7                              Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 14:43:51  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 7| 5| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 6| 0| 2| 2| 2| 2| 2| 2| 2|                                            |            |
                                           | 0| 8| 5| 9| 8| 8| 8| 9| 9| 7|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|                                            |     A      |
    0 PPM                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|                                            |     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  M  +  +  +  +  +  +  +  +                                             |  34        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  +  +  +  M  +  +  +  +                                             |  28        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  M  +  +  +  +  M  +  +  +                                             |  29        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  35        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  35        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Penis                                   | +           +                                                            |   6        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |             +                                                            |   3        |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +                                             |  34        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  35        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   3        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  35        |
      Femoral, Lymphoma Malignant          |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  I  +  +  +  +  +  +  +  +                                             |  31        |
      Bronchial, Lymphoma Malignant        |                                                                          |            |
          Lymphocytic                      | X                                                                        |          1 |
      Lumbar, Lymphoma Malignant Mixed     |                                                                          |          2 |
      Mediastinal, Lymphoma Malignant      |                                                                          |            |
          Histiocytic                      |                                                                          |          1 |
      Mediastinal, Lymphoma Malignant Mixed|                                                                          |          2 |
      Mesenteric, Lymphoma Malignant       |                                                                          |            |
          Histiocytic                      |                                                                          |          1 |
      Mesenteric, Lymphoma Malignant Mixed |                                                                          |          1 |
      Renal, Lymphoma Malignant Mixed      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  I  +  +  +  +  +  +  +  +                                             |  31        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       | X                          X                                             |          3 |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  A  +  +  +  +  +  +  +  +                                             |  34        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  36                                                               
NTP Experiment-Test: 05074-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  PENTACHLOROPHENOL, DOWICIDE EC7                              Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 14:43:51  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 7| 5| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 6| 0| 2| 2| 2| 2| 2| 2| 2|                                            |            |
                                           | 0| 8| 5| 9| 8| 8| 8| 9| 9| 7|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|                                            |     A      |
    0 PPM                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|                                            |     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Lymphoma Malignant Lymphocytic       | X                          X                                             |          3 |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  M  +  +  M  +  +  +  M  +                                             |  21        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M                                             |            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  34        |
      Subcutaneous Tissue, Fibrosarcoma    |       X                                                                  |          4 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  35        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  35        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  35        |
      Alveolar/Bronchiolar Adenoma         |                         X                                                |          5 |
      Fibrosarcoma, Metastatic, Skin       |                                                                          |          1 |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Pheochromocytoma Malignant,          |                                                                          |            |
          Metastatic, Adrenal Gland        | X                                                                        |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  35        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  35        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +  +  M  M  +  +  +  +  +  +                                             |  27        |
      Adenoma                              |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  35        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Urethra                                 |             +                                                            |   3        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  33        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +                                             |  35        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  37                                                               
NTP Experiment-Test: 05074-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  PENTACHLOROPHENOL, DOWICIDE EC7                              Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 14:43:51  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 7| 5| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 6| 0| 2| 2| 2| 2| 2| 2| 2|                                            |            |
                                           | 0| 8| 5| 9| 8| 8| 8| 9| 9| 7|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|                                            |     A      |
    0 PPM                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|                                            |     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       | X                          X                                             |          3 |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  38                                                               
NTP Experiment-Test: 05074-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  PENTACHLOROPHENOL, DOWICIDE EC7                              Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 14:43:51  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 4| 2| 6| 7| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 5| 5| 7| 7| 7|             
                             DAY ON TEST   | 9| 7| 5| 1| 2| 5| 2| 2| 2| 2| 1| 3| 5| 0| 2| 2| 2| 5| 3| 2| 1| 6| 2| 2| 2|             
                                           | 5| 7| 4| 3| 7| 9| 9| 8| 8| 8| 1| 0| 5| 5| 9| 8| 8| 9| 0| 9| 3| 8| 7| 8| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6|             
    100 PPM                                | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    A  M  +                    +                             +  +         |             
                                            __________________________________________________________________________|             
   Gallbladder                             |    A  A  A                    +                             A  +         |             
                                            __________________________________________________________________________|             
   Intestine Large                         |    A  +  +                    +                             A  +         |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    A  M  M                    +                             A  +         |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    A  +  +                    +                             A  +         |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    A  M  A                    +                             A  M         |             
                                            __________________________________________________________________________|             
   Intestine Small                         |    A  +  +                    +                             A  +         |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    A  A  +                    +                             A            |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    A  +  +                    +                             A            |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    A  +  +                    +                             A            |             
                                            __________________________________________________________________________|             
   Liver                                   | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Fibrosarcoma, Metastatic, Skin       |                                                                          |             
      Hemangiosarcoma                      |                                                                          |             
      Hemangiosarcoma, Multiple            |                            X        X                                    |             
      Hepatocellular Carcinoma             | X              X                                                        X|             
      Hepatocellular Carcinoma, Multiple   |                                                    X                     |             
      Hepatocellular Adenoma               |                   X                    X              X              X   |             
      Hepatocellular Adenoma, Multiple     |          X                                      X        X               |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |    A  +  +                    +                             A  +         |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    A  M  +                    +                             +  +         |             
                                            __________________________________________________________________________|             
   Stomach                                 |    A  +  +                    +                             A  +         |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    A  +  +                    +                             A  +         |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    A  +  +                    +                             A  +         |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +  +  +                    +                             +  +         |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Capsule, Adenoma                     |                         X                                                |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Pheochromocytoma Benign              |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    A  +  +                    +                             A  +         |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    A  M  M                    +                             +  +         |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    M  M  +                    +                             M  +         |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    A  M  +                    +                             +  +         |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |    +  +  +                    +                             +  +         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  39                                                               
NTP Experiment-Test: 05074-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  PENTACHLOROPHENOL, DOWICIDE EC7                              Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 14:43:51  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 4| 2| 6| 7| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 5| 5| 7| 7| 7|             
                             DAY ON TEST   | 9| 7| 5| 1| 2| 5| 2| 2| 2| 2| 1| 3| 5| 0| 2| 2| 2| 5| 3| 2| 1| 6| 2| 2| 2|             
                                           | 5| 7| 4| 3| 7| 9| 9| 8| 8| 8| 1| 0| 5| 5| 9| 8| 8| 9| 0| 9| 3| 8| 7| 8| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6|             
    100 PPM                                | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Penis                                   |                         +  +                          +                 +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         |    +                                                  +        +         |             
                                            __________________________________________________________________________|             
   Prostate                                |    A  +  +                    +                             A  +         |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                            +                                +            |             
                                            __________________________________________________________________________|             
   Testes                                  |    +  +  +                    +                             A  +         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    A  +  +                    +                             A  +         |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    A  M  M                 +  +        +                    +  M         |             
      Mesenteric, Lymphoma Malignant Mixed |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |    A  M  M                    +                             +  M         |             
                                            __________________________________________________________________________|             
   Spleen                                  |    A  +  +                 +  +        +                    A  +        +|             
      Hemangiosarcoma                      |                                                                          |             
      Hemangiosarcoma, Multiple            |                            X                                             |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |    M  M  M                    M                             A  M         |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    M  M  M                    M                             M  M         |             
                                            __________________________________________________________________________|             
   Skin                                    | +  A  +  +  +     +  +     +  +  +     +  +  +        +  +  +  +  +      |             
      Papilloma, Multiple                  |                                                                          |             
      Sebaceous Gland, Carcinoma           |                                        X                                 |             
      Subcutaneous Tissue, Fibroma         |                                              X                           |             
      Subcutaneous Tissue, Fibrosarcoma    |          X  X        X                                   X               |             
      Subcutaneous Tissue, Fibrosarcoma,   |                                                                          |             
           Multiple                        |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +  +  +  +     +  +     +  +  +  +     +     +  +  +     +  +         |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                       +                  |             
      Intercostal, Fibrosarcoma,           |                                                                          |             
          Metastatic, Skin                 |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    A  +  +                    +                             +  +         |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |    +  +  +                    +  +                    +     +  +         |             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Interstitium, Mediastinum,           |                                                                          |             
          Fibrosarcoma, Multiple,          |                                                                          |             
          Metastatic, Skin                 |                                                       X                  |             
                                            __________________________________________________________________________|             
   Nose                                    |    +  +  +                    +                             +  +         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  40                                                               
NTP Experiment-Test: 05074-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  PENTACHLOROPHENOL, DOWICIDE EC7                              Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 14:43:51  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 4| 2| 6| 7| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 5| 5| 7| 7| 7|             
                             DAY ON TEST   | 9| 7| 5| 1| 2| 5| 2| 2| 2| 2| 1| 3| 5| 0| 2| 2| 2| 5| 3| 2| 1| 6| 2| 2| 2|             
                                           | 5| 7| 4| 3| 7| 9| 9| 8| 8| 8| 1| 0| 5| 5| 9| 8| 8| 9| 0| 9| 3| 8| 7| 8| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6|             
    100 PPM                                | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 |    A  M  +                    +                             +  +         |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |    +  M  +                    +                          +  A  +         |             
      Adenoma                              |                                                          X               |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    A  +  +     +  +           +           +                 A  +         |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                             +            |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    A  +  +                    +                             A  +         |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  41                                                               
NTP Experiment-Test: 05074-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  PENTACHLOROPHENOL, DOWICIDE EC7                              Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 14:43:51  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 3| 6| 7| 4| 7| 4| 5| 6| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4|            |
                             DAY ON TEST   | 1| 0| 9| 2| 3| 2| 4| 3| 1| 2| 2| 3| 2| 6| 3| 2| 2| 2| 2| 2| 9| 2| 2| 2| 8|            |
                                           | 2| 5| 0| 9| 1| 7| 0| 2| 2| 8| 3| 0| 7| 3| 0| 8| 7| 9| 7| 7| 7| 8| 8| 7| 9|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9|     A      |
    100 PPM                                | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |    +        +     +  +  +              +                                +|  11        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |    +        A     A  +  A              +                                A|   5        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |    +        +     +  +  +              A                                +|  10        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |    +        A     M  +  +              A                                A|   5        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |    +        +     +  +  +              A                                +|  10        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |    +        A     +  +  +              A                                +|   6        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |    +        A     M  +  +              A                                A|   7        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |    +        A     M  +  +              A                                A|   5        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |    +        A     M  +  +              A                                A|   6        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |    +        A     M  +  +              A                                A|   6        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Fibrosarcoma, Metastatic, Skin       |                X                                                         |          1 |
      Hemangiosarcoma                      |                                  X                                       |          1 |
      Hemangiosarcoma, Multiple            |                                                                          |          2 |
      Hepatocellular Carcinoma             |                         X     X                                X         |          6 |
      Hepatocellular Carcinoma, Multiple   |                                                                          |          1 |
      Hepatocellular Adenoma               |                            X  X     X     X  X                       X   |         10 |
      Hepatocellular Adenoma, Multiple     |                                                                          |          3 |
      Lymphoma Malignant Histiocytic       |       X                                                     X            |          2 |
                                            __________________________________________________________________________|____________|
   Pancreas                                |    +        +     +  +  +              +                          +     +|  12        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |    +        +     +  +  +              +                                +|  11        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |    +        +     +  +  +              +                                +|  11        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |    +        +     +  +  +              +                                +|  11        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |    +        +     +  +  +              +                                +|  11        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |    +        +     +  +  +              +                                +|  13        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Capsule, Adenoma                     |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Pheochromocytoma Benign              |                               X  X                 X           X         |          4 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |    +        +     +  +  +              +                                +|  11        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |    +        +     +  +  +              +                                +|  10        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |    +        +     M  +  +              +                                +|   9        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |    +        +     +  +  +              +                                +|  11        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  42                                                               
NTP Experiment-Test: 05074-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  PENTACHLOROPHENOL, DOWICIDE EC7                              Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 14:43:51  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 3| 6| 7| 4| 7| 4| 5| 6| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4|            |
                             DAY ON TEST   | 1| 0| 9| 2| 3| 2| 4| 3| 1| 2| 2| 3| 2| 6| 3| 2| 2| 2| 2| 2| 9| 2| 2| 2| 8|            |
                                           | 2| 5| 0| 9| 1| 7| 0| 2| 2| 8| 3| 0| 7| 3| 0| 8| 7| 9| 7| 7| 7| 8| 8| 7| 9|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9|     A      |
    100 PPM                                | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |    +        +     +  +  +              +                                +|  13        |
                                            __________________________________________________________________________|____________|
   Penis                                   | +        +                                                               |   6        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +     +                                +                          +   |   8        |
                                            __________________________________________________________________________|____________|
   Prostate                                |    +        +     +  +  +              +                                +|  11        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |    +                                                                     |   3        |
                                            __________________________________________________________________________|____________|
   Testes                                  |    +        +     +  +  +              +                                +|  12        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |    +        +     +  +  +              +                                A|  10        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  M        +     +  +  +  +           +                 +           +  +|  14        |
      Mesenteric, Lymphoma Malignant Mixed |                            X                                             |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |    M        +     +  +  +              +                                +|   8        |
                                            __________________________________________________________________________|____________|
   Spleen                                  |    +        +  +  +  +  +  +           +     +              +        +  +|  19        |
      Hemangiosarcoma                      |                                                                      X   |          1 |
      Hemangiosarcoma, Multiple            |                                                                          |          1 |
      Lymphoma Malignant Histiocytic       |                                                             X            |          1 |
      Lymphoma Malignant Mixed             |                            X                 X                           |          2 |
                                            __________________________________________________________________________|____________|
   Thymus                                  |    +        +     M  +  +              +                                M|   5        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |    M        M     M  M  M              M                                M|            |
                                            __________________________________________________________________________|____________|
   Skin                                    |    +        +  +  +  +  +  +           +        +  +  +  +        +  +  +|  32        |
      Papilloma, Multiple                  |                                                 X                        |          1 |
      Sebaceous Gland, Carcinoma           |                                                                          |          1 |
      Subcutaneous Tissue, Fibroma         |                                                          X               |          2 |
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |          4 |
      Subcutaneous Tissue, Fibrosarcoma,   |                                                                          |            |
           Multiple                        |                X                                                         |          2 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +     +  +  +  +  +        +  +  +  +  +     +  +  +  +  +  +     +|  36        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
      Intercostal, Fibrosarcoma,           |                                                                          |            |
          Metastatic, Skin                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |    +        +     +  +  +              +                                +|  12        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  43                                                               
NTP Experiment-Test: 05074-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  PENTACHLOROPHENOL, DOWICIDE EC7                              Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 14:43:51  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 3| 6| 7| 4| 7| 4| 5| 6| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4|            |
                             DAY ON TEST   | 1| 0| 9| 2| 3| 2| 4| 3| 1| 2| 2| 3| 2| 6| 3| 2| 2| 2| 2| 2| 9| 2| 2| 2| 8|            |
                                           | 2| 5| 0| 9| 1| 7| 0| 2| 2| 8| 3| 0| 7| 3| 0| 8| 7| 9| 7| 7| 7| 8| 8| 7| 9|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9|     A      |
    100 PPM                                | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |    +        +     +  +  +              +                                +|  15        |
      Alveolar/Bronchiolar Adenoma         |                         X                                                |          1 |
      Interstitium, Mediastinum,           |                                                                          |            |
          Fibrosarcoma, Multiple,          |                                                                          |            |
          Metastatic, Skin                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    |    +        +     +  +  +              +                                +|  13        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |    +        +     +  +  +              +                                +|  11        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     | +                                                                        |   1        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |    +        +     +  +  +              +                                +|  12        |
      Adenoma                              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |    +        +     +  +  +              +                                +|  14        |
                                            __________________________________________________________________________|____________|
   Urethra                                 |             +                                                            |   2        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +        +     +  +  +              A                                +|  11        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Histiocytic       |       X                                                     X            |          2 |
      Lymphoma Malignant Mixed             |                            X                 X                           |          2 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  44                                                               
NTP Experiment-Test: 05074-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  PENTACHLOROPHENOL, DOWICIDE EC7                              Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 14:43:51  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 3| 3| 7| 6| 1| 3| 7| 7| 5| 7| 2| 2| 7| 2| 2|             
                             DAY ON TEST   | 8| 1| 2| 3| 2| 3| 2| 2| 3| 3| 2| 5| 2| 6| 4| 1| 2| 3| 9| 2| 9| 9| 2| 9| 9|             
                                           | 1| 6| 9| 0| 7| 0| 9| 8| 0| 0| 4| 2| 7| 0| 0| 5| 7| 0| 8| 9| 3| 2| 7| 3| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|             
    200 PPM                                | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +                          +  +        +  +        A     +  +     A  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             |    +                          +  A        +  +        A     A  A     A  A|             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +                          +  +        +  +        A     +  +     A  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +                          +  A        M  +        A     A  +     A  A|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +                          +  +        +  +        A     +  +     A  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +                          +  +        M  +        A     A  M     A  A|             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +                          +  +        M  +        A     A  +     A  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    A                          +  A        M  +        A     A  +     A  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    A                          +  A        M  +        A     A  +     A  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +                          +  +        M  +        A     A  +     A  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +|             
      Hemangioma                           |                                                                          |             
      Hemangiosarcoma                      |                                                 X                        |             
      Hepatocellular Carcinoma             |             X                                   X                        |             
      Hepatocellular Carcinoma, Multiple   |       X                                                                  |             
      Hepatocellular Adenoma               | X                 X     X                                                |             
      Hepatocellular Adenoma, Multiple     |             X                       X  X                          X      |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +                          +  M        +  +        A     +  +     M  +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +                          +  +        +  +        A     +  +     A  +|             
                                            __________________________________________________________________________|             
   Stomach                                 |    +                          +  +        +  +        A     A  +     A  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +                          +  +        +  +        A     A  +     A  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +                          +  +        +  +        A     A  +     A  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +                          +  +        +  +        +     +  +     +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  A  +|             
      Pheochromocytoma Benign              |                                                 X                        |             
      Bilateral, Pheochromocytoma Benign   |       X     X     X  X              X  X           X  X  X        X      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +                          +  M        +  +        A     +  +     M  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    +                          +  +        M  +        M     M  M     M  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +                          +  +        +  +        M     I  +     M  +|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +                          +  +        +  +        M     M  +     A  +|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |    +                          +  +        +  +        +     +  +     +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  45                                                               
NTP Experiment-Test: 05074-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  PENTACHLOROPHENOL, DOWICIDE EC7                              Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 14:43:51  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 3| 3| 7| 6| 1| 3| 7| 7| 5| 7| 2| 2| 7| 2| 2|             
                             DAY ON TEST   | 8| 1| 2| 3| 2| 3| 2| 2| 3| 3| 2| 5| 2| 6| 4| 1| 2| 3| 9| 2| 9| 9| 2| 9| 9|             
                                           | 1| 6| 9| 0| 7| 0| 9| 8| 0| 0| 4| 2| 7| 0| 0| 5| 7| 0| 8| 9| 3| 2| 7| 3| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|             
    200 PPM                                | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |    +              +                          +                           |             
                                            __________________________________________________________________________|             
   Prostate                                |    +                          +  +        +  +        M     M  +     +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  |    +                          +  +        +  +        +     +  +     +  +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +                          +  +        +  +        A     A  A     A  +|             
      Femoral, Lymphoma Malignant          |                                                                          |             
          Histiocytic                      |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +        +                 +  +  +     +  +        M     +  +     +  M|             
      Lumbar, Lymphoma Malignant Mixed     |                                                                          |             
      Mesenteric, Lymphoma Malignant       |                                                                          |             
          Histiocytic                      |                                                                          |             
      Mesenteric, Lymphoma Malignant Mixed |                                                                          |             
      Renal, Lymphoma Malignant Mixed      |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |    +                          +  +        +  +        M     +  +     +  M|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  |    +                          +  +        +  +  +     A     A  +     A  +|             
      Hemangiosarcoma                      |                                                 X                        |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |    +                          +  +        M  +        M     M  +     A  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    M                          M  M        M  M        M     M  M     M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +                          I  +        +  +  +  +  A  +  +  +     +  +|             
      Subcutaneous Tissue, Fibroma         |                                                 X                        |             
      Subcutaneous Tissue, Fibrosarcoma    |                                                    X                     |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +           +              +  +        +  +  +     +  +  +  +     +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +                          +  +        +  +        A     +  +     +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |    +                          +  +  +     +  +        +  +  +  +     +  +|             
      Alveolar/Bronchiolar Adenoma         |                                     X                                    |             
      Alveolar/Bronchiolar Carcinoma       |                                                          X               |             
      Fibrosarcoma, Metastatic, Skin       |                                                                          |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |    +                          +  +        M  +        +     +  +     +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  46                                                               
NTP Experiment-Test: 05074-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  PENTACHLOROPHENOL, DOWICIDE EC7                              Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 14:43:51  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 3| 3| 7| 6| 1| 3| 7| 7| 5| 7| 2| 2| 7| 2| 2|             
                             DAY ON TEST   | 8| 1| 2| 3| 2| 3| 2| 2| 3| 3| 2| 5| 2| 6| 4| 1| 2| 3| 9| 2| 9| 9| 2| 9| 9|             
                                           | 1| 6| 9| 0| 7| 0| 9| 8| 0| 0| 4| 2| 7| 0| 0| 5| 7| 0| 8| 9| 3| 2| 7| 3| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|             
    200 PPM                                | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 |    +                          +  +        +  +        A     +  +     A  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |    +                          M  +        M  +        +     +  +     +  +|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +                       +  +  +        +  +        A     +  +     +  +|             
      Renal Tubule, Adenoma                |                            X                                             |             
                                            __________________________________________________________________________|             
   Urethra                                 |    +                          +  +                                      +|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +                          +  +        +  +        A     A  +     A  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  47                                                               
NTP Experiment-Test: 05074-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  PENTACHLOROPHENOL, DOWICIDE EC7                              Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 14:43:51  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 1| 6| 7| 5| 7| 7| 3| 7| 0| 7| 7| 7| 7| 6| 6| 7| 7| 7| 5| 7| 7|            |
                             DAY ON TEST   | 5| 2| 2| 2| 3| 9| 2| 4| 2| 2| 4| 2| 2| 2| 2| 3| 2| 0| 0| 2| 3| 2| 7| 2| 3|            |
                                           | 1| 9| 9| 9| 4| 0| 9| 1| 7| 8| 2| 7| 6| 9| 8| 0| 7| 8| 3| 7| 0| 8| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5|     A      |
    200 PPM                                | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +           +        +        M     +              +  +           +      |  15        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +           +        +        A     +              A  A           +      |   9        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +           +        +        +     +              +  +           +      |  16        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | M           +        +        +     M              M  +           +      |   9        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +           +        +        +     +              +  +           +      |  16        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +           A        +        M     M              M  +           +      |   8        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +           +        +        +     +              M  +           +      |  13        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +           +        +        +     +              M  +           +      |  11        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +           A        +        +     M              M  +           +      |   8        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +           +        +        +     M              M  +           +      |  12        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hemangioma                           |          X                                                               |          1 |
      Hemangiosarcoma                      |                X                                                         |          2 |
      Hepatocellular Carcinoma             |    X                                   X     X  X                        |          6 |
      Hepatocellular Carcinoma, Multiple   |                                                                          |          1 |
      Hepatocellular Adenoma               |                            X              X     X  X     X           X   |          9 |
      Hepatocellular Adenoma, Multiple     |          X              X              X                                X|          8 |
      Lymphoma Malignant Histiocytic       |                      X                                                   |          1 |
      Lymphoma Malignant Mixed             |                X                                                         |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +           +        +        M     +              +  +           +      |  14        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +           +        +        M     +              +  +           +      |  15        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +           +        +        +     +              +  +           +      |  15        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +           +        +        +     +              +  +           +      |  15        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +           +        +        +     +              +  +           +      |  15        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +           +        +        M     +              +  +           +      |  17        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Pheochromocytoma Benign              |                                  X           X           X               |          4 |
      Bilateral, Pheochromocytoma Benign   |    X  X  X              X              X        X                       X|         17 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +           +        +        M     +              +  +           +      |  14        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +           +        +        M     M  +           +  +           +      |  11        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +           +        +        M     +              +  +           +      |  14        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +           +        +        M     +              +  +           +      |  14        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  48                                                               
NTP Experiment-Test: 05074-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  PENTACHLOROPHENOL, DOWICIDE EC7                              Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 14:43:51  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 1| 6| 7| 5| 7| 7| 3| 7| 0| 7| 7| 7| 7| 6| 6| 7| 7| 7| 5| 7| 7|            |
                             DAY ON TEST   | 5| 2| 2| 2| 3| 9| 2| 4| 2| 2| 4| 2| 2| 2| 2| 3| 2| 0| 0| 2| 3| 2| 7| 2| 3|            |
                                           | 1| 9| 9| 9| 4| 0| 9| 1| 7| 8| 2| 7| 6| 9| 8| 0| 7| 8| 3| 7| 0| 8| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5|     A      |
    200 PPM                                | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +           +        +        +     +              +  +           +      |  18        |
                                            __________________________________________________________________________|____________|
   Penis                                   |                                     +                                    |   1        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                         +                                                |   4        |
                                            __________________________________________________________________________|____________|
   Prostate                                | +           +        +        +     +              M  +           +      |  15        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                                     +                 +                  |   2        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +           +        +        +     +              +  +           +      |  18        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                    +                     |   1        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +           +        +        +     +              +  +           +      |  14        |
      Femoral, Lymphoma Malignant          |                                                                          |            |
          Histiocytic                      |                      X                                                   |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +        M  +  +  +  +     M     M        +  +  +  +  +        +      |  22        |
      Lumbar, Lymphoma Malignant Mixed     |                X  X                                                      |          2 |
      Mesenteric, Lymphoma Malignant       |                                                                          |            |
          Histiocytic                      |                      X                                                   |          1 |
      Mesenteric, Lymphoma Malignant Mixed |                X  X                                                      |          2 |
      Renal, Lymphoma Malignant Mixed      |                X  X                                                      |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +           M        +        M     M              +  +           +      |  13        |
      Lymphoma Malignant Histiocytic       |                      X                                                   |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +           +  +  +  +     +  M     +        +     +  +           +     +|  20        |
      Hemangiosarcoma                      |                                                                          |          1 |
      Lymphoma Malignant Histiocytic       |                      X                                                   |          1 |
      Lymphoma Malignant Mixed             |                X  X                          X                           |          3 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | M           +        +        M     +              +  M           +      |  11        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M           M        M        M     M              M  M           M      |            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +           +     +  +     +  +  +  +           +  +  +     +     +     +|  26        |
      Subcutaneous Tissue, Fibroma         |                                                                          |          1 |
      Subcutaneous Tissue, Fibrosarcoma    |                            X                    X  X  X           X      |          6 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +        +  +  +     +        +     +        +  +  +  +  +        +  +  +|  29        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +           +        +        M     +              +  +           +      |  16        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  49                                                               
NTP Experiment-Test: 05074-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  PENTACHLOROPHENOL, DOWICIDE EC7                              Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 14:43:51  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 1| 6| 7| 5| 7| 7| 3| 7| 0| 7| 7| 7| 7| 6| 6| 7| 7| 7| 5| 7| 7|            |
                             DAY ON TEST   | 5| 2| 2| 2| 3| 9| 2| 4| 2| 2| 4| 2| 2| 2| 2| 3| 2| 0| 0| 2| 3| 2| 7| 2| 3|            |
                                           | 1| 9| 9| 9| 4| 0| 9| 1| 7| 8| 2| 7| 6| 9| 8| 0| 7| 8| 3| 7| 0| 8| 8| 9| 0|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     T      |
                               ANIMAL ID   | 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5|     A      |
    200 PPM                                | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +           +        +        M     +              +  +           +      |  19        |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          1 |
      Alveolar/Bronchiolar Carcinoma       |                                                                          |          1 |
      Fibrosarcoma, Metastatic, Skin       |                                                    X                     |          1 |
      Lymphoma Malignant Histiocytic       |                      X                                                   |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +           +        +        +     M              +  +           +      |  16        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +           +        +        M     +              +  +           +      |  15        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +           +        +        M     M              +  M           +      |  13        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +           +     +  +        +     +              +  +           +     +|  20        |
      Renal Tubule, Adenoma                |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urethra                                 |                                                                          |   4        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +           +  +     +        +     +              A  +           +      |  15        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoma Malignant Histiocytic       |                      X                                                   |          1 |
      Lymphoma Malignant Mixed             |                X  X                          X                           |          3 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  50                                                               
NTP Experiment-Test: 05074-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  PENTACHLOROPHENOL, DOWICIDE EC7                              Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 14:43:51  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 3| 7| 7| 7| 0| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 0| 0| 2| 3| 2| 6| 2| 2| 3| 5| 3| 2| 2| 3| 3| 3| 2| 2| 2| 2| 2| 2| 2| 3| 0|             
                                           | 8| 4| 7| 0| 9| 5| 7| 9| 0| 7| 0| 9| 8| 5| 0| 0| 8| 8| 8| 8| 8| 8| 8| 0| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8|             
    600 PPM                                | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             |    +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +  +  +  +  +  +  +  +  M  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Peyer's Patch, Lymphoma Malignant    |                                                                          |             
          Mixed                            |                                                                   X      |             
                                            __________________________________________________________________________|             
   Liver                                   |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemangioma                           |                                                                          |             
      Hemangioma, Multiple                 |                                     X                                    |             
      Hemangiosarcoma                      |                                                                          |             
      Hemangiosarcoma, Multiple            |                                                                          |             
      Hepatocellular Carcinoma             |                   X              X                          X  X         |             
      Hepatocellular Carcinoma, Multiple   |                                                                          |             
      Hepatocellular Adenoma               |             X     X              X              X              X  X      |             
      Hepatocellular Adenoma, Multiple     |          X           X  X     X     X  X     X        X  X  X        X   |             
      Lymphoma Malignant Histiocytic       |                                                                         X|             
      Lymphoma Malignant Mixed             |                                                                          |             
      Pheochromocytoma Malignant,          |                                                                          |             
          Metastatic, Adrenal Gland        |                                                                      X   |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   |    +                                                                     |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pheochromocytoma Malignant           |                                  X                                   X   |             
      Pheochromocytoma Benign              |                                  X                                   X  X|             
      Bilateral, Pheochromocytoma Malignant|          X                                                               |             
      Bilateral, Pheochromocytoma Benign   |    X  X     X     X  X  X     X     X  X  X  X  X  X  X  X  X  X  X      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  51                                                               
NTP Experiment-Test: 05074-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  PENTACHLOROPHENOL, DOWICIDE EC7                              Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 14:43:51  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 3| 7| 7| 7| 0| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 0| 0| 2| 3| 2| 6| 2| 2| 3| 5| 3| 2| 2| 3| 3| 3| 2| 2| 2| 2| 2| 2| 2| 3| 0|             
                                           | 8| 4| 7| 0| 9| 5| 7| 9| 0| 7| 0| 9| 8| 5| 0| 0| 8| 8| 8| 8| 8| 8| 8| 0| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8|             
    600 PPM                                | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    +  +  +  +  +  M  +  M  M  M  +  +  +  M  +  M  +  +  +  +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +  +  +  +  +  +  +  +  M  +  M  +  M  M  M  M  +  M  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                   +      |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                                           +     +                        |             
                                            __________________________________________________________________________|             
   Prostate                                |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mediastinal, Lymphoma Malignant Mixed|                                                                X         |             
      Mesenteric, Lymphoma Malignant Mixed |                                                                X  X      |             
      Pancreatic, Lymphoma Malignant Mixed |                                                                X         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                   X      |             
                                            __________________________________________________________________________|             
   Spleen                                  |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                                                                X  X      |             
                                            __________________________________________________________________________|             
   Thymus                                  |    +  +  M  M  +  M  M  +  M  M  +  +  M  +  +  +  M  +  +  M  M  M  +  M|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Squamous Cell Papilloma              |                      X                                                   |             
      Subcutaneous Tissue, Fibroma         |                                                                          |             
      Subcutaneous Tissue, Fibrosarcoma    |          X                                                               |             
      Subcutaneous Tissue, Sarcoma         |                                        X                                 |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |       X                                                              X   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  52                                                               
NTP Experiment-Test: 05074-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  PENTACHLOROPHENOL, DOWICIDE EC7                              Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 14:43:51  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 3| 7| 7| 7| 0| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 0| 0| 2| 3| 2| 6| 2| 2| 3| 5| 3| 2| 2| 3| 3| 3| 2| 2| 2| 2| 2| 2| 2| 3| 0|             
                                           | 8| 4| 7| 0| 9| 5| 7| 9| 0| 7| 0| 9| 8| 5| 0| 0| 8| 8| 8| 8| 8| 8| 8| 0| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8|             
    600 PPM                                | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Alveolar/Bronchiolar Adenoma,        |                                                                          |             
          Multiple                         |                                                             X            |             
      Hepatocellular Carcinoma, Metastatic |                                                             X            |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                  X                                       |             
      Pheochromocytoma Malignant,          |                                                                          |             
          Metastatic, Adrenal Gland        |                                  X                                   X   |             
                                            __________________________________________________________________________|             
   Nose                                    |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 |    +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                      +                                                   |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |    +  +  +  +  +  +  +  +  M  M  M  +  M  +  +  +  +  +  M  +  +  +  +  +|             
      Adenoma                              |    X                 X                                                   |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                X         |             
      Renal Tubule, Adenoma                |                      X                                                   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                         X|             
      Lymphoma Malignant Mixed             |                                                                X  X      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  53                                                               
NTP Experiment-Test: 05074-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  PENTACHLOROPHENOL, DOWICIDE EC7                              Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 14:43:51  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 7| 2| 7| 7| 6| 4| 7| 7| 6| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 9| 2| 1| 5| 2| 2| 1| 5| 2| 2| 8| 3| 2| 3| 2| 3| 7| 2| 2| 3| 2| 2| 3| 1|            |
                                           | 6| 5| 9| 1| 3| 9| 8| 1| 8| 9| 7| 0| 0| 8| 0| 8| 0| 9| 7| 8| 0| 7| 9| 0| 7|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|     T      |
                               ANIMAL ID   | 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1|     A      |
    600 PPM                                | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  47        |
      Peyer's Patch, Lymphoma Malignant    |                                                                          |            |
          Mixed                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hemangioma                           |                   X                                                      |          1 |
      Hemangioma, Multiple                 |                                                                          |          1 |
      Hemangiosarcoma                      |                X           X                                             |          2 |
      Hemangiosarcoma, Multiple            |                                                                X         |          1 |
      Hepatocellular Carcinoma             |                   X                       X              X              X|          8 |
      Hepatocellular Carcinoma, Multiple   |                               X                                          |          1 |
      Hepatocellular Adenoma               | X                 X                                      X        X      |         10 |
      Hepatocellular Adenoma, Multiple     |    X  X        X           X        X  X  X     X           X  X     X   |         22 |
      Lymphoma Malignant Histiocytic       |                               X                                          |          2 |
      Lymphoma Malignant Mixed             |                                                                   X      |          1 |
      Pheochromocytoma Malignant,          |                                                                          |            |
          Metastatic, Adrenal Gland        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                 +     +                  |   3        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  54                                                               
NTP Experiment-Test: 05074-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  PENTACHLOROPHENOL, DOWICIDE EC7                              Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 14:43:51  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 7| 2| 7| 7| 6| 4| 7| 7| 6| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 9| 2| 1| 5| 2| 2| 1| 5| 2| 2| 8| 3| 2| 3| 2| 3| 7| 2| 2| 3| 2| 2| 3| 1|            |
                                           | 6| 5| 9| 1| 3| 9| 8| 1| 8| 9| 7| 0| 0| 8| 0| 8| 0| 9| 7| 8| 0| 7| 9| 0| 7|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|     T      |
                               ANIMAL ID   | 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1|     A      |
    600 PPM                                | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Pheochromocytoma Malignant           |                                                                          |          2 |
      Pheochromocytoma Benign              |                         X                                         X      |          5 |
      Bilateral, Pheochromocytoma Malignant|                                                                          |          1 |
      Bilateral, Pheochromocytoma Benign   | X  X  X  X     X  X  X     X  X  X  X  X  X  X  X     X  X  X  X     X  X|         39 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  41        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  I  +  M  +  +  +  +  +  +  +|  38        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Penis                                   |                                        +        +        +               |   4        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                                        +                 +               |   4        |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |             +                                                            |   1        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  47        |
      Mediastinal, Lymphoma Malignant Mixed|                                                                   X      |          2 |
      Mesenteric, Lymphoma Malignant Mixed |                                                                   X      |          3 |
      Pancreatic, Lymphoma Malignant Mixed |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  47        |
      Lymphoma Malignant Mixed             |                                                                   X      |          2 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Lymphoma Malignant Mixed             |                                                                   X      |          3 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  M  +  +  +  +  +  +  +  M  M  M  +  +  +  M  M  M  M  +  +  +  +  +  M|  27        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Squamous Cell Papilloma              |                                                                          |          1 |
      Subcutaneous Tissue, Fibroma         |          X                                                               |          1 |
      Subcutaneous Tissue, Fibrosarcoma    | X  X                 X                             X                    X|          6 |
      Subcutaneous Tissue, Sarcoma         |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  55                                                               
NTP Experiment-Test: 05074-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                  PENTACHLOROPHENOL, DOWICIDE EC7                              Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 14:43:51  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 7| 2| 7| 7| 6| 4| 7| 7| 6| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 9| 2| 1| 5| 2| 2| 1| 5| 2| 2| 8| 3| 2| 3| 2| 3| 7| 2| 2| 3| 2| 2| 3| 1|            |
                                           | 6| 5| 9| 1| 3| 9| 8| 1| 8| 9| 7| 0| 0| 8| 0| 8| 0| 9| 7| 8| 0| 7| 9| 0| 7|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|     T      |
                               ANIMAL ID   | 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1|     A      |
    600 PPM                                | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Alveolar/Bronchiolar Adenoma         |                                                 X        X               |          4 |
      Alveolar/Bronchiolar Adenoma,        |                                                                          |            |
          Multiple                         |                                                                          |          1 |
      Hepatocellular Carcinoma, Metastatic |                                                                          |          1 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                                          |          1 |
      Pheochromocytoma Malignant,          |                                                                          |            |
          Metastatic, Adrenal Gland        |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  M  M  M  +  +  +  M  M  +  +  +  M  +  M  M  +  +  +  +  +  +  M|  35        |
      Adenoma                              |                                                          X               |          3 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Lymphoma Malignant Histiocytic       |                               X                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                   X      |          2 |
      Renal Tubule, Adenoma                |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Lymphoma Malignant Histiocytic       |                               X                                          |          2 |
      Lymphoma Malignant Mixed             |                                                                   X      |          3 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  56                                                               
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