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TR 349 Mouse Pathology Tables


                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                  DOWICIDE EC-7 PENTACHLOROPHENOL


NTP Experiment-Test: 05074-01                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/09/94
Route: DOSED FEED                                                                                                 Time: 06:47:19




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  87-86-5

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05074-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                  DOWICIDE EC-7 PENTACHLOROPHENOL                              Date: 09/09/94  
Route: DOSED FEED                                                                                                 Time: 06:47:19  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 PPM        100 PPM      200 PPM      600 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          35           50           50           50                                     
  Early Deaths                                                                                                                      
    Natural Death                                      3           15           10           11                                     
    Moribund Sacrifice                                 3            6            2                                                  
    Drowned                                                         1                                                               
  Survivors                                                                                                                         
    Terminal Sacrifice                                29           28           38           39                                     
  Animals Examined Microscopically                    35           50           50           49                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (34)         (10)         (3)          (45)                                   
      Leiomyoma                                        1 (3%)                                                                       
   Intestine Large, Colon                             (34)         (13)         (4)          (47)                                   
      Leiomyoma                                                     1 (8%)                                                          
   Intestine Small, Jejunum                           (34)         (10)         (3)          (47)                                   
   Liver                                              (34)         (50)         (49)         (48)                                   
      Fibrosarcoma, Metastatic, Skin                                             1 (2%)                                             
      Hemangioma                                                                              1 (2%)                                
      Hemangiosarcoma                                                                         4 (8%)                                
      Hemangiosarcoma, Multiple                                     1 (2%)       1 (2%)       4 (8%)                                
      Hemangiosarcoma, Metastatic, Spleen                                        2 (4%)                                             
      Hepatocellular Carcinoma                                      1 (2%)                    2 (4%)                                
      Hepatocellular Adenoma                           1 (3%)       3 (6%)       5 (10%)      9 (19%)                               
      Hepatocellular Adenoma, Multiple                                           1 (2%)      21 (44%)                               
   Mesentery                                                       (4)          (1)          (2)                                    
      Hemangiosarcoma                                                                         1 (50%)                               
      Myxosarcoma, Metastatic, Skin                                                           1 (50%)                               
   Pancreas                                           (34)         (16)         (7)          (46)                                   
      Hemangiosarcoma, Metastatic, Spleen                                        1 (14%)                                            
   Salivary Glands                                    (35)         (12)         (3)          (46)                                   
   Stomach, Forestomach                               (33)         (14)         (5)          (47)                                   
      Squamous Cell Papilloma                          1 (3%)                                                                       
   Tongue                                                                       (1)                                                 
      Mucosa, Dorsal, Squamous Cell Carcinoma                                    1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (35)         (14)         (5)          (48)                                   
      Hemangiosarcoma, Metastatic, Spleen                                                     1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   2                                                               
NTP Experiment-Test: 05074-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                  DOWICIDE EC-7 PENTACHLOROPHENOL                              Date: 09/09/94  
Route: DOSED FEED                                                                                                 Time: 06:47:19  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 PPM        100 PPM      200 PPM      600 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (35)         (50)         (47)         (49)                                   
      Capsule, Adenoma                                              2 (4%)                                                          
      Capsule, Carcinoma                                            1 (2%)                                                          
   Adrenal Gland, Cortex                              (35)         (49)         (47)         (49)                                   
   Adrenal Gland, Medulla                             (35)         (49)         (46)         (49)                                   
      Pheochromocytoma Malignant                                    1 (2%)                    1 (2%)                                
      Pheochromocytoma Benign                                       1 (2%)       2 (4%)       9 (18%)                               
      Bilateral, Pheochromocytoma Benign                                                     29 (59%)                               
   Islets, Pancreatic                                 (34)         (16)         (5)          (46)                                   
      Carcinoma                                                     2 (13%)                                                         
   Pituitary Gland                                    (32)         (17)         (9)          (44)                                   
      Pars Distalis, Adenoma                           9 (28%)      3 (18%)      4 (44%)      6 (14%)                               
      Pars Distalis, Adenoma, Multiple                 1 (3%)                                                                       
      Pars Intermedia, Adenoma                                      1 (6%)                                                          
   Thyroid Gland                                      (34)         (14)         (4)          (46)                                   
      Follicular Cell, Adenoma                         3 (9%)                                 3 (7%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (34)         (24)         (17)         (48)                                   
   Uterus                                             (34)         (36)         (41)         (47)                                   
      Leiomyoma                                                                  1 (2%)       1 (2%)                                
      Leiomyosarcoma                                                                          1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (35)         (13)         (5)          (48)                                   
      Hemangiosarcoma                                                                         1 (2%)                                
   Lymph Node                                         (34)         (23)         (11)         (44)                                   
   Lymph Node, Mandibular                             (33)         (16)         (4)          (42)                                   
   Spleen                                             (34)         (26)         (17)         (47)                                   
      Hemangiosarcoma                                                            2 (12%)      2 (4%)                                
   Thymus                                             (30)         (9)          (5)          (43)                                   
      Thymoma Malignant                                1 (3%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   3                                                               
NTP Experiment-Test: 05074-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                  DOWICIDE EC-7 PENTACHLOROPHENOL                              Date: 09/09/94  
Route: DOSED FEED                                                                                                 Time: 06:47:19  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 PPM        100 PPM      200 PPM      600 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (33)         (6)          (7)          (40)                                   
      Adenocarcinoma                                   3 (9%)       1 (17%)      2 (29%)      4 (10%)                               
   Skin                                               (35)         (22)         (18)         (46)                                   
      Subcutaneous Tissue, Fibrosarcoma                             1 (5%)       1 (6%)                                             
      Subcutaneous Tissue, Hemangiosarcoma                                       1 (6%)                                             
      Subcutaneous Tissue, Myxosarcoma                                                        1 (2%)                                
      Subcutaneous Tissue, Sarcoma                                  1 (5%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                    (1)          (1)                                                              
      Sarcoma, Metastatic, Skin                                     1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (35)         (15)         (6)          (48)                                   
      Adenocarcinoma, Metastatic, Mammary Gland        1 (3%)                                 1 (2%)                                
      Alveolar/Bronchiolar Adenoma                     1 (3%)       2 (13%)      1 (17%)      2 (4%)                                
      Alveolar/Bronchiolar Adenoma, Multiple                        1 (7%)                                                          
      Alveolar/Bronchiolar Carcinoma                                                          1 (2%)                                
      Alveolar/Bronchiolar Carcinoma, Multiple         1 (3%)                                                                       
      Hepatocellular Carcinoma, Metastatic                                                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (29)         (12)         (4)          (23)                                   
      Adenoma                                          2 (7%)       1 (8%)       1 (25%)      3 (13%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (34)         (15)         (8)          (48)                                   
   Urinary Bladder                                    (34)         (12)         (5)          (47)                                   
                                                             Page   4                                                               
NTP Experiment-Test: 05074-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                  DOWICIDE EC-7 PENTACHLOROPHENOL                              Date: 09/09/94  
Route: DOSED FEED                                                                                                 Time: 06:47:19  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 PPM        100 PPM      200 PPM      600 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(35)        *(50)        *(50)        *(49)                                   
      Lymphoma Malignant                                            1 (2%)                                                          
      Lymphoma Malignant Histiocytic                   1 (3%)       1 (2%)       3 (6%)       2 (4%)                                
      Lymphoma Malignant Lymphocytic                  11 (31%)      4 (8%)       4 (8%)      11 (22%)                               
      Lymphoma Malignant Mixed                         3 (9%)      11 (22%)      6 (12%)      3 (6%)                                
      Lymphoma Malignant Undifferentiated Cell                      1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   5                                                               
NTP Experiment-Test: 05074-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                  DOWICIDE EC-7 PENTACHLOROPHENOL                              Date: 09/09/94  
Route: DOSED FEED                                                                                                 Time: 06:47:19  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 PPM        100 PPM      200 PPM      600 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            24          29          25          46                                       
     Total Primary Neoplasms                           39          42          37         122                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 13          12          13          44                                       
     Total Benign Neoplasms                            19          15          15          84                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              18          24          18          31                                       
     Total Malignant Neoplasms                         20          27          22          38                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              1           1           3           4                                       
     Total Metastatic Neoplasm                          1           1           4           4                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   6                                                               
NTP Experiment-Test: 05074-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                  DOWICIDE EC-7 PENTACHLOROPHENOL                              Date: 09/09/94  
Route: DOSED FEED                                                                                                 Time: 06:47:19  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 PPM        100 PPM      200 PPM      600 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          35           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 2            3            4            6                                     
    Natural Death                                      8           19           17            9                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                25           28           29           35                                     
  Animals Examined Microscopically                    35           50           50           49                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Small, Jejunum                           (32)         (6)          (12)         (47)                                   
   Liver                                              (35)         (48)         (48)         (49)                                   
      Fibrosarcoma, Metastatic, Skin                                1 (2%)                                                          
      Hemangioma                                       1 (3%)                    1 (2%)       1 (2%)                                
      Hemangioma, Multiple                                                                    1 (2%)                                
      Hemangiosarcoma                                               1 (2%)       2 (4%)       2 (4%)                                
      Hemangiosarcoma, Multiple                                     2 (4%)                    1 (2%)                                
      Hepatocellular Carcinoma                         1 (3%)       6 (13%)      6 (13%)      8 (16%)                               
      Hepatocellular Carcinoma, Multiple                            1 (2%)       1 (2%)       1 (2%)                                
      Hepatocellular Adenoma                           5 (14%)     10 (21%)      9 (19%)     10 (20%)                               
      Hepatocellular Adenoma, Multiple                              3 (6%)       8 (17%)     22 (45%)                               
      Pheochromocytoma Malignant, Metastatic,                                                                                       
          Adrenal Gland                                                                       1 (2%)                                
   Pancreas                                           (34)         (12)         (14)         (49)                                   
   Salivary Glands                                    (35)         (11)         (15)         (49)                                   
   Stomach, Glandular                                 (33)         (11)         (15)         (49)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (35)         (13)         (17)         (49)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (34)         (48)         (49)         (49)                                   
      Capsule, Adenoma                                              1 (2%)                                                          
   Adrenal Gland, Cortex                              (34)         (48)         (48)         (49)                                   
      Adenoma                                          1 (3%)                                                                       
   Adrenal Gland, Medulla                             (34)         (48)         (48)         (49)                                   
      Pheochromocytoma Malignant                       1 (3%)                                 2 (4%)                                
      Pheochromocytoma Benign                                       4 (8%)       4 (8%)       5 (10%)                               
      Bilateral, Pheochromocytoma Malignant                                                   1 (2%)                                
                                                             Page   7                                                               
NTP Experiment-Test: 05074-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                  DOWICIDE EC-7 PENTACHLOROPHENOL                              Date: 09/09/94  
Route: DOSED FEED                                                                                                 Time: 06:47:19  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 PPM        100 PPM      200 PPM      600 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
      Bilateral, Pheochromocytoma Benign                                        17 (35%)     39 (80%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (35)         (13)         (18)         (49)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (35)         (10)         (14)         (49)                                   
   Lymph Node                                         (31)         (14)         (22)         (47)                                   
   Lymph Node, Mandibular                             (31)         (8)          (13)         (47)                                   
   Spleen                                             (34)         (19)         (20)         (49)                                   
      Hemangiosarcoma                                               1 (5%)       1 (5%)                                             
      Hemangiosarcoma, Multiple                                     1 (5%)                                                          
   Thymus                                             (21)         (5)          (11)         (27)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (34)         (32)         (26)         (49)                                   
      Papilloma, Multiple                                           1 (3%)                                                          
      Squamous Cell Papilloma                                                                 1 (2%)                                
      Sebaceous Gland, Carcinoma                                    1 (3%)                                                          
      Subcutaneous Tissue, Fibroma                                  2 (6%)       1 (4%)       1 (2%)                                
      Subcutaneous Tissue, Fibrosarcoma                4 (12%)      4 (13%)      6 (23%)      6 (12%)                               
      Subcutaneous Tissue, Fibrosarcoma, Multiple                   2 (6%)                                                          
      Subcutaneous Tissue, Sarcoma                                                            1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                                 (1)                                                              
      Intercostal, Fibrosarcoma, Metastatic, Skin                   1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   8                                                               
NTP Experiment-Test: 05074-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                  DOWICIDE EC-7 PENTACHLOROPHENOL                              Date: 09/09/94  
Route: DOSED FEED                                                                                                 Time: 06:47:19  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 PPM        100 PPM      200 PPM      600 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (35)         (15)         (19)         (49)                                   
      Alveolar/Bronchiolar Adenoma                     5 (14%)      1 (7%)       1 (5%)       4 (8%)                                
      Alveolar/Bronchiolar Adenoma, Multiple                                                  1 (2%)                                
      Alveolar/Bronchiolar Carcinoma                                             1 (5%)                                             
      Fibrosarcoma, Metastatic, Skin                   1 (3%)                    1 (5%)                                             
      Hepatocellular Carcinoma, Metastatic                                                    1 (2%)                                
      Hepatocellular Carcinoma, Metastatic, Liver                                             1 (2%)                                
      Pheochromocytoma Malignant, Metastatic,                                                                                       
          Adrenal Gland                                1 (3%)                                 2 (4%)                                
      Interstitium, Mediastinum, Fibrosarcoma,                                                                                      
           Multiple, Metastatic, Skin                               1 (7%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (27)         (12)         (13)         (35)                                   
      Adenoma                                          2 (7%)       1 (8%)                    3 (9%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (35)         (14)         (20)         (49)                                   
      Renal Tubule, Adenoma                                                      1 (5%)       1 (2%)                                
   Urinary Bladder                                    (33)         (11)         (15)         (49)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(35)        *(50)        *(50)        *(49)                                   
      Lymphoma Malignant Histiocytic                   1 (3%)       2 (4%)       1 (2%)       2 (4%)                                
      Lymphoma Malignant Lymphocytic                   3 (9%)                                                                       
      Lymphoma Malignant Mixed                         2 (6%)       2 (4%)       3 (6%)       3 (6%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   9                                                               
NTP Experiment-Test: 05074-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                  DOWICIDE EC-7 PENTACHLOROPHENOL                              Date: 09/09/94  
Route: DOSED FEED                                                                                                 Time: 06:47:19  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 PPM        100 PPM      200 PPM      600 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            20          32          33          46                                       
     Total Primary Neoplasms                           26          46          63         116                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 11          21          28          45                                       
     Total Benign Neoplasms                            14          23          42          89                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              10          22          16          22                                       
     Total Malignant Neoplasms                         12          23          21          27                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              2           2           1           3                                       
     Total Metastatic Neoplasm                          2           3           1           5                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  10                                                               
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