National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/2117

TR 349 Mouse Pathology Tables

NTP Experiment-Test: 05074-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  PENTACHLOROPHENOL, DOWICIDE EC7                              Date: 05/05/97
Route: DOSED FEED                                                                                                 Time: 14:47:10




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  87-86-5

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All






































                                                              Page   1

NTP Experiment-Test: 05074-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  PENTACHLOROPHENOL, DOWICIDE EC7                              Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 14:47:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 2| 2| 2| 8| 2| 3| 2| 2| 2| 2| 3| 2| 4| 2| 2| 2| 2| 2| 3| 2| 3| 2| 2| 3| 9|             
                                           | 7| 2| 8| 5| 8| 0| 9| 9| 8| 9| 0| 8| 3| 8| 8| 7| 7| 8| 0| 8| 0| 8| 7| 0| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                 X                        |             
      Clear Cell Focus                     |                               X                                          |             
      Hematopoietic Cell Proliferation,    |                                                                          |             
           Multifocal                      | 2  2  2     2  2  2        2  2  3        2  2  2        2     2  2      |             
      Infarct                              |                                                             2            |             
      Hepatocyte, Necrosis, Acute, Focal   |                                                          2     1         |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |    2                                            3                    2   |             
      Duct, Cyst                           |                                                                          |             
      Duct, Ectasia                        |                                                 4                        |             
      Duct, Hyperplasia                    |                                                                          |             
      Duct, Inflammation, Chronic          |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +     +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +     +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Cyst                        |                                                                          |             
      Capsule, Hyperplasia                 | 3  3  3  3  3  3  3  3  3  3  3  3  2  3  3  3  3  3  3  3  3  2  3  3  3|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                  2                                       |             
      Hyperplasia                          |       2                                                                  |             
      Hypertrophy                          |    2     2                 2  2                          2               |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                            2                                             |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05074-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  PENTACHLOROPHENOL, DOWICIDE EC7                              Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 14:47:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 2| 2| 2| 8| 2| 3| 2| 2| 2| 2| 3| 2| 4| 2| 2| 2| 2| 2| 3| 2| 3| 2| 2| 3| 9|             
                                           | 7| 2| 8| 5| 8| 0| 9| 9| 8| 9| 0| 8| 3| 8| 8| 7| 7| 8| 0| 8| 0| 8| 7| 0| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                               X                                          |             
      Pars Distalis, Hyperplasia           |    2  2     3              3  3  2     3  4     3     3  3  2  2         |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                   2                                                      |             
      Follicle, Cyst                       |                         X                       X                        |             
      Follicular Cell, Hyperplasia         |                   4                             2  4                     |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                      3                                         3         |             
      Inflammation, Chronic Active         |                                  4                                4      |             
      Follicle, Cyst                       |                               X        X  X  X  X     X     X            |             
      Periovarian Tissue, Cyst             |       X        X     X                                                   |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Thrombosis                           |                               X  X                                       |             
      Endometrium, Hyperplasia, Cystic,    |                                                                          |             
           Glandular, Multifocal           | 3  2  3  4  3  3  3  4  3  2  2  3     2  3  3  3  2  3  3  4  3  2  3   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femoral, Myelofibrosis               |    2  2  2     2  4        2              2  2  2              2  2      |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesenteric, Hyperplasia, Lymphoid    |                                                                          |             
      Renal, Hyperplasia, Lymphoid         |                                  4                                       |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +     +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Pigmentation, Diffuse                |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis                             |                                                                          |             
      Red Pulp, Hematopoietic Cell         |                                                                          |             
          Proliferation, Diffuse           |                                  3                                       |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  M  M  M  +  +  +  +  +  +  +  +  M  +  +|             
      Degeneration, Acute                  |    2                                                                     |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Hyperplasia, Cystic                  |    2  2  3  2  2  2              3        2  2     2        2  2     3   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alopecia                             |                X        X                 X                 X            |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05074-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  PENTACHLOROPHENOL, DOWICIDE EC7                              Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 14:47:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 2| 2| 2| 8| 2| 3| 2| 2| 2| 2| 3| 2| 4| 2| 2| 2| 2| 2| 3| 2| 3| 2| 2| 3| 9|             
                                           | 7| 2| 8| 5| 8| 0| 9| 9| 8| 9| 0| 8| 3| 8| 8| 7| 7| 8| 0| 8| 0| 8| 7| 0| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                                                          |             
      Meninges, Infiltration Cellular,     |                                                                          |             
           Lymphocyte                      |       2  2           2                                   2               |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar Epithelium, Hyperplasia     |                3                                                         |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Olfactory Epithelium, Metaplasia,    |                                                                          |             
           Focal                           |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +     +  M  +  M  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy, Chronic                 |                                                                          |             
      Renal Tubule, Regeneration           |                                                    2                     |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05074-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  PENTACHLOROPHENOL, DOWICIDE EC7                              Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 14:47:10  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 1| 2| 2| 3| 3| 2| 2| 2| 2| 2|                                            |            |
                                           | 7| 8| 0| 0| 0| 7| 7| 8| 7| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  34        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  M  +                                             |  32        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +                                             |  34        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  34        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  34        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  34        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +                                             |  34        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  34        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  34        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  34        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  34        |
      Basophilic Focus                     |                                                                          |      1     |
      Clear Cell Focus                     |                                                                          |      1     |
      Hematopoietic Cell Proliferation,    |                                                                          |            |
           Multifocal                      |             2  2  2     2  2                                             |     20  2.1|
      Infarct                              | 2                                                                        |      2  2.0|
      Hepatocyte, Necrosis, Acute, Focal   |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  34        |
      Acinus, Atrophy                      |                2  3                                                      |      5  2.4|
      Duct, Cyst                           |                   X                                                      |      1     |
      Duct, Ectasia                        |                   3                                                      |      2  3.5|
      Duct, Hyperplasia                    |                            2                                             |      1  2.0|
      Duct, Inflammation, Chronic          |                   3                                                      |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  35        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +                                             |  34        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  33        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  33        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  35        |
      Inflammation, Chronic                |                2                                                         |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  35        |
      Capsule, Cyst                        |                            X                                             |      1     |
      Capsule, Hyperplasia                 | 3  3  3  3  3  3  3  3  3  3                                             |     35  2.9|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +                                             |  35        |
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Hyperplasia                          |          2                                                               |      2  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   5                                                               
NTP Experiment-Test: 05074-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  PENTACHLOROPHENOL, DOWICIDE EC7                              Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 14:47:10  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 1| 2| 2| 3| 3| 2| 2| 2| 2| 2|                                            |            |
                                           | 7| 8| 0| 0| 0| 7| 7| 8| 7| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Hypertrophy                          |                            2                                             |      6  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +                                             |  35        |
      Hyperplasia                          |                         3                                                |      2  2.5|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  34        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +                                             |  35        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | M  +  +  +  I  +  +  +  +  +                                             |  32        |
      Pars Distalis, Cyst                  |                                                                          |      1     |
      Pars Distalis, Hyperplasia           |          2           3  2                                                |     16  2.6|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  34        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Follicle, Cyst                       |                                                                          |      2     |
      Follicular Cell, Hyperplasia         |       2        2                                                         |      5  2.8|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  34        |
      Angiectasis                          |                                                                          |      2  3.0|
      Inflammation, Chronic Active         |                4                                                         |      3  4.0|
      Follicle, Cyst                       | X     X        X  X                                                      |     11     |
      Periovarian Tissue, Cyst             |                                                                          |      3     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  34        |
      Thrombosis                           |                                                                          |      2     |
      Endometrium, Hyperplasia, Cystic,    |                                                                          |            |
           Glandular, Multifocal           | 2  2     3  3     2  2  2  4                                             |     31  2.8|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  35        |
      Femoral, Myelofibrosis               |          4              2                                                |     13  2.3|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +                                             |  34        |
      Mesenteric, Hyperplasia, Lymphoid    |                3                                                         |      1  3.0|
      Renal, Hyperplasia, Lymphoid         |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  33        |
      Hyperplasia, Lymphoid                |                3                                                         |      1  3.0|
      Pigmentation, Diffuse                | 3                                                                        |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  34        |
      Necrosis                             |       4                                                                  |      1  4.0|
      Red Pulp, Hematopoietic Cell         |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   6                                                               
NTP Experiment-Test: 05074-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  PENTACHLOROPHENOL, DOWICIDE EC7                              Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 14:47:10  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 1| 2| 2| 3| 3| 2| 2| 2| 2| 2|                                            |            |
                                           | 7| 8| 0| 0| 0| 7| 7| 8| 7| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
          Proliferation, Diffuse           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +     +  +                                             |  30        |
      Degeneration, Acute                  |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  +  +  +  +  +  +  +  +  +                                             |  33        |
      Hyperplasia, Cystic                  |    2  3  3     3     2  2                                                |     19  2.3|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  35        |
      Alopecia                             |    X                                                                     |      5     |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  35        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                      +                                                   |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  35        |
      Compression                          |                3                                                         |      1  3.0|
      Meninges, Infiltration Cellular,     |                                                                          |            |
           Lymphocyte                      |          2     2                                                         |      6  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  35        |
      Alveolar Epithelium, Hyperplasia     |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  35        |
      Olfactory Epithelium, Metaplasia,    |                                                                          |            |
           Focal                           |       2                                                                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  34        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +  +  M  +  +  +  +  +  +  +                                             |  29        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  34        |
      Nephropathy, Chronic                 |          1  2     2                                                      |      3  1.7|
      Renal Tubule, Regeneration           |                            2                                             |      2  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  34        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   7                                                               
NTP Experiment-Test: 05074-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  PENTACHLOROPHENOL, DOWICIDE EC7                              Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 14:47:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 5| 6| 5| 7| 7| 4| 7| 4| 3| 7| 7| 7| 6|             
                             DAY ON TEST   | 5| 2| 2| 2| 0| 2| 3| 2| 2| 3| 2| 2| 6| 2| 9| 3| 2| 4| 2| 8| 2| 2| 2| 2| 4|             
                                           | 4| 8| 9| 8| 1| 7| 0| 7| 8| 0| 1| 7| 6| 9| 6| 0| 7| 3| 7| 3| 1| 7| 9| 7| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    100 PPM                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +                             +     +  +  +        +     +  +            |             
                                            __________________________________________________________________________|             
   Gallbladder                             | A                             +     +  A  +        +     +  +            |             
                                            __________________________________________________________________________|             
   Intestine Large                         | A                             +     +  +  +        +     +  +            |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | A                             +     +  A  +        +     A  +            |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | A                             +     +  +  +        +     +  +            |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | A                             +     +  +  M        +     +  +            |             
                                            __________________________________________________________________________|             
   Intestine Small                         | A                             +     +  +  +        +     A  +            |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | A                             A     +  +  +        +     A  +            |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | A                             +     +  A  +        +     A  +            |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | A                             +     +  A  +        +     A  +            |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Clear Cell Focus                     |                                        X        X                        |             
      Hematopoietic Cell Proliferation,    |                                                                          |             
           Multifocal                      |    2  2  2  2  2  2  3  2  2     2  2  2     2  2                 2  2  2|             
      Infarct                              |                                  3        3                              |             
      Inflammation, Chronic Active, Diffuse|                1     1                                                   |             
      Pigmentation, Multifocal             |                   2  2                          2                 1      |             
      Hepatocyte, Cytomegaly, Diffuse      | 2           1  1  1  1        1  2  1  1  2     1  2     2  1  1  1  1  1|             
      Hepatocyte, Cytomegaly, Focal        |                                                       2                  |             
      Hepatocyte, Necrosis, Acute, Diffuse | 2              1  1  1     1  1  1  1  1  2     1  2     1               |             
      Hepatocyte, Necrosis, Acute, Focal   |                                                       2                  |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                     +  +                                 |             
      Inflammation, Chronic Active         |                                     3  3                                 |             
                                            __________________________________________________________________________|             
   Pancreas                                | +                             +     +  +  +        +     +  +            |             
      Hyperplasia, Lymphoid                |                                     2                                    |             
      Acinus, Atrophy                      |                                                                          |             
      Duct, Cyst                           |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | M                             +     +  +  +        +     +  +            |             
                                            __________________________________________________________________________|             
   Stomach                                 | +                             +     +  +  +        +     +  +            |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +                             +     +  +  +        +     +  +            |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +                             +     A  +  +        +     +  +            |             
      Necrosis, Acute, Focal               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +                             +     +  +  +        +     +  +            |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Hyperplasia                 |    3  3  3  2  3  2  3  3  3  2  3  3  3  3  2  2  2  3  2  3  3  3  3  2|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                                                          |             
      Cyst                                 |    X                                                                     |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   8                                                               
NTP Experiment-Test: 05074-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  PENTACHLOROPHENOL, DOWICIDE EC7                              Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 14:47:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 5| 6| 5| 7| 7| 4| 7| 4| 3| 7| 7| 7| 6|             
                             DAY ON TEST   | 5| 2| 2| 2| 0| 2| 3| 2| 2| 3| 2| 2| 6| 2| 9| 3| 2| 4| 2| 8| 2| 2| 2| 2| 4|             
                                           | 4| 8| 9| 8| 1| 7| 0| 7| 8| 0| 1| 7| 6| 9| 6| 0| 7| 3| 7| 3| 1| 7| 9| 7| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    100 PPM                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Hypertrophy                          |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                 2                        |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +                          +  +     +  +  +        +     +  +            |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M                             +     +  +  +        M     +  +            |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +     +                       +     +  +  +        +  +  +  +            |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +                             +     +  +  +        +     +  +            |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +           +  +  +           +     +  +  +        +     +  +        +  +|             
      Inflammation, Chronic Active         |             4                 4     4  4                                4|             
      Follicle, Cyst                       | X                 X           X                                      X   |             
      Periovarian Tissue, Cyst             | X              X                                                         |             
                                            __________________________________________________________________________|             
   Uterus                                  | +        +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +     +  +   |             
      Angiectasis                          |                                                                          |             
      Inflammation, Acute                  |                2                                                         |             
      Inflammation, Chronic Active         |                                        4                                 |             
      Endometrium, Hyperplasia, Cystic,    |                                                                          |             
           Glandular, Multifocal           |          3  2  3  3  3  3  4        2  3  3  3  4  2              3  4   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                          +               |             
      Lymphocytosis                        |                                                          X               |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | A                             +     +  +  +        +     +  +            |             
      Femoral, Hyperplasia, Neutrophil     |                                     3  3                                 |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +              +        +     +     +  +  +  +     +     +  +            |             
      Mediastinal, Hyperplasia, Lymphoid   |                                     3                                    |             
      Mediastinal, Inflammation, Acute     |                                                                          |             
      Mesenteric, Hematopoietic Cell       |                                                                          |             
          Proliferation                    |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M              +              +     +  +  +        +     +  +            |             
      Hyperplasia, Lymphoid                |                                     3                                    |             
                                            __________________________________________________________________________|             
   Spleen                                  | +     +     +  +              +  +  +  +  +        +     +  +           +|             
      Hyperplasia, Lymphoid                |                                     4                                    |             
      Red Pulp, Hematopoietic Cell         |                                                                          |             
          Proliferation, Diffuse           |             4                          3           4                    4|             
                                            __________________________________________________________________________|             
   Thymus                                  | +                             +     M  M  M        M     +  +            |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M                             M     +  M  M        +     M  M           +|             
      Hyperplasia, Cystic                  |                                     2                                    |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   9                                                               
NTP Experiment-Test: 05074-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  PENTACHLOROPHENOL, DOWICIDE EC7                              Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 14:47:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 5| 6| 5| 7| 7| 4| 7| 4| 3| 7| 7| 7| 6|             
                             DAY ON TEST   | 5| 2| 2| 2| 0| 2| 3| 2| 2| 3| 2| 2| 6| 2| 9| 3| 2| 4| 2| 8| 2| 2| 2| 2| 4|             
                                           | 4| 8| 9| 8| 1| 7| 0| 7| 8| 0| 1| 7| 6| 9| 6| 0| 7| 3| 7| 3| 1| 7| 9| 7| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    100 PPM                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +                    +        +  +  +  +  +        +  +  +  +        +   |             
      Alopecia                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +                             +     +  +  +        +     +  +            |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                    +                     |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +                             +     +  +  +        +     +  +            |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +                          +     +  +  +        +     +  +            |             
                                            __________________________________________________________________________|             
   Nose                                    | +                             +     +  +  +        +     +  +            |             
                                            __________________________________________________________________________|             
   Trachea                                 | +                             +     +  +  +        +     +  +            |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Atrophy                              |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +        +                    +     +  +  M        +     +  +            |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +                             +     +  +  +        +     +  +            |             
      Glomerulus, Amyloid Deposition,      |                                                                          |             
          Diffuse                          |                                                             4            |             
      Renal Tubule, Dilatation             |                                                             3            |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                             +            |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | A                             +     +  +  +        +     +  +            |             
      Dilatation                           |                                                             4            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  10                                                               
NTP Experiment-Test: 05074-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  PENTACHLOROPHENOL, DOWICIDE EC7                              Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 14:47:10  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 4| 5| 5| 7| 6| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 9| 7| 4| 3| 3| 3| 2| 1| 6| 1| 4| 3| 1| 2| 3| 3| 2| 6| 2| 2| 2| 2|            |
                                           | 0| 0| 0| 7| 2| 2| 0| 1| 0| 8| 3| 9| 4| 5| 6| 2| 7| 0| 0| 7| 4| 9| 9| 0| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    100 PPM                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |          +  +  +     +                    +                 +            |  14        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |          +  A  +     +                    +                 +            |  11        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |          +  +  +     +     +              +                 +            |  14        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |          +  +  +                          +                 +            |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |          +  +  +           +              +                 +            |  13        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |          +  +  +                          +                 +            |  11        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |          +  +  +     +                    +                 +            |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |          +  +  +                          +                 +            |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |          +  +  +                          +                 +            |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |          +  +  +                          +                 +            |  10        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Clear Cell Focus                     |                                                                          |      2     |
      Hematopoietic Cell Proliferation,    |                                                                          |            |
           Multifocal                      | 2  2  2  2  2        2  2  2  2  2  3     2  3     2  2  3     2  3  3  2|     37  2.2|
      Infarct                              |                                                                          |      2  3.0|
      Inflammation, Chronic Active, Diffuse|                                           2  2                           |      4  1.5|
      Pigmentation, Multifocal             |                                                                          |      4  1.8|
      Hepatocyte, Cytomegaly, Diffuse      | 1  1  1  1     1  1     1  1  1  1  2     1     1     1  1     1  1  1  1|     37  1.2|
      Hepatocyte, Cytomegaly, Focal        |                                                                          |      1  2.0|
      Hepatocyte, Necrosis, Acute, Diffuse | 1     1        1  1     1     1  1                                      2|     21  1.2|
      Hepatocyte, Necrosis, Acute, Focal   |                                        2  1  1                           |      4  1.5|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                     +     +                              |   4        |
      Inflammation, Chronic Active         |                                           3                              |      3  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                |    +     +  +  +     +              +     +                 +            |  16        |
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Acinus, Atrophy                      |    4                                                                     |      1  4.0|
      Duct, Cyst                           |    X                                                                     |      1     |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |          +  +  +     +                    +                 M            |  12        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |          +  +  +     +                    +                 +            |  14        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |          +  +  +     +                    +                 +            |  14        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |          +  +  +     +                    +                 +            |  13        |
      Necrosis, Acute, Focal               |                                           2                              |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |          +  +  +     +                    +                 +            |  14        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Capsule, Hyperplasia                 | 3  3  3  2  2  3  3  3  2  2  2  3  2  3  3  2  2  2  2  3  2  2  3  3  2|     49  2.6|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  11                                                               
NTP Experiment-Test: 05074-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  PENTACHLOROPHENOL, DOWICIDE EC7                              Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 14:47:10  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 4| 5| 5| 7| 6| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 9| 7| 4| 3| 3| 3| 2| 1| 6| 1| 4| 3| 1| 2| 3| 3| 2| 6| 2| 2| 2| 2|            |
                                           | 0| 0| 0| 7| 2| 2| 0| 1| 0| 8| 3| 9| 4| 5| 6| 2| 7| 0| 0| 7| 4| 9| 9| 0| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    100 PPM                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|  49        |
      Accessory Adrenal Cortical Nodule    |                                                       X                  |      1     |
      Cyst                                 |                                                                          |      1     |
      Hematopoietic Cell Proliferation     |                                                             2            |      1  2.0|
      Hyperplasia                          |                                                                   2      |      1  2.0|
      Hypertrophy                          |                         3                             1                  |      2  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +        +  +  +     +                    +                 +            |  16        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |          M  +  +     +                    +                 +            |  11        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +        +  +  +     M     +              +                 +            |  17        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |          +  +  +     +                    +                 +            |  14        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +        +  +  +     +              +     +  +        +     +        +   |  24        |
      Inflammation, Chronic Active         |                                           4  4                       4   |      8  4.0|
      Follicle, Cyst                       | X              X                    X                                    |      7     |
      Periovarian Tissue, Cyst             |                                                       X                  |      3     |
                                            __________________________________________________________________________|____________|
   Uterus                                  |    +     +  +  +     +  +        +        +  +  +  +  +  +  +  +  +     +|  36        |
      Angiectasis                          |                                                             2            |      1  2.0|
      Inflammation, Acute                  |                                  3              3        2               |      4  2.5|
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
      Endometrium, Hyperplasia, Cystic,    |                                                                          |            |
           Glandular, Multifocal           |    3     2     2     2  2        2        3  3  3  2  2  3     3  4     3|     30  2.8|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   1        |
      Lymphocytosis                        |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |          +  +  +     +                    +                 +            |  13        |
      Femoral, Hyperplasia, Neutrophil     |                                           3                              |      3  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |          +  +  +  +  +        +     +  +  +  +              +  +         |  23        |
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |      1  3.0|
      Mediastinal, Inflammation, Acute     |                                              3                           |      1  3.0|
      Mesenteric, Hematopoietic Cell       |                                                                          |            |
          Proliferation                    |                3                                                         |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |          +  +  +  +  +        +        +  +                 M            |  16        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  12                                                               
NTP Experiment-Test: 05074-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  PENTACHLOROPHENOL, DOWICIDE EC7                              Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 14:47:10  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 4| 5| 5| 7| 6| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 9| 7| 4| 3| 3| 3| 2| 1| 6| 1| 4| 3| 1| 2| 3| 3| 2| 6| 2| 2| 2| 2|            |
                                           | 0| 0| 0| 7| 2| 2| 0| 1| 0| 8| 3| 9| 4| 5| 6| 2| 7| 0| 0| 7| 4| 9| 9| 0| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    100 PPM                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  |          +  +  +  +  +  +     +     +  +  +  +              +        +   |  26        |
      Hyperplasia, Lymphoid                |                                                                          |      1  4.0|
      Red Pulp, Hematopoietic Cell         |                                                                          |            |
          Proliferation, Diffuse           |                                     3     3  3                       4   |      8  3.5|
                                            __________________________________________________________________________|____________|
   Thymus                                  |          M  +  M     +                 +  +                 +            |   9        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |          +  +  M     M                    +                 M            |   6        |
      Hyperplasia, Cystic                  |                                           2                              |      2  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    |          +  +  +     +                    +     +  +  +     +  +         |  22        |
      Alopecia                             |                                                                X         |      1     |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |          +  +  +     +                    +                 +            |  14        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |          +  +  +     +                    +                 +            |  14        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |          +  +  +     +                    +                 +            |  15        |
                                            __________________________________________________________________________|____________|
   Nose                                    |          +  +  +     +                    +                 +            |  14        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |          +  +  +     +                    +                 +            |  14        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                +                                                         |   1        |
      Atrophy                              |                4                                                         |      1  4.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |          +  +  M     M                    +                 +            |  12        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |          +  +  +  +  +                    +                 +            |  15        |
      Glomerulus, Amyloid Deposition,      |                                                                          |            |
          Diffuse                          |                                                                          |      1  4.0|
      Renal Tubule, Dilatation             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Urethra                                 |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |          +  +  M     +                    +                 +            |  12        |
      Dilatation                           |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  13                                                               
NTP Experiment-Test: 05074-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  PENTACHLOROPHENOL, DOWICIDE EC7                              Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 14:47:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 2| 2| 2| 2| 3| 9| 2| 1| 2| 2| 2| 2| 3| 0| 3| 3| 2| 8| 3| 2| 2| 2| 2| 2|             
                                           | 0| 8| 8| 8| 7| 0| 9| 9| 1| 9| 8| 7| 7| 5| 6| 0| 0| 9| 9| 0| 7| 9| 9| 8| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    200 PPM                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |                                        +                                 |             
                                            __________________________________________________________________________|             
   Gallbladder                             |                                        A                                 |             
                                            __________________________________________________________________________|             
   Intestine Large                         |                                        +                                 |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |                                        +                                 |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                                        +                                 |             
      Parasite Metazoan                    |                                        X                                 |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |                                        +                                 |             
                                            __________________________________________________________________________|             
   Intestine Small                         |                                        +                                 |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |                                        +                                 |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |                                        +                                 |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                                        +                                 |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                                          |             
      Clear Cell Focus                     |                                                                          |             
      Clear Cell Focus, Multiple           |             X  X              X                 X                        |             
      Degeneration, Cystic                 |                                                                3         |             
      Hematopoietic Cell Proliferation,    |                                                                          |             
           Multifocal                      | 1     2     2  2           2     2     3  2  3     3  2  2  2  2  2  2  2|             
      Inflammation, Chronic Active, Diffuse| 1  1  1     1  1     1  1     1  1  1  2  2  2     2  2  1     1         |             
      Inflammation, Chronic Active, Focal  |                                                                          |             
      Pigmentation, Multifocal             | 2  1  1  2  2  1                 2  2  2     2     2  2                 2|             
      Bile Duct, Cyst                      |                                                 X                        |             
      Bile Duct, Cyst, Multiple            |                            X                                             |             
      Bile Duct, Hyperplasia, Multifocal   |                                                                          |             
      Hepatocyte, Cytomegaly, Diffuse      | 2  2  2  1  2  2  2  1  2  2  2  2  3  2  2  3  2  2  2  2  2  2  2  2  2|             
      Hepatocyte, Necrosis, Acute, Diffuse | 2  1  2  1  2  1  2  1  2  1  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2|             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |                                        +                                 |             
      Duct, Ectasia                        |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |                                        M                                 |             
                                            __________________________________________________________________________|             
   Stomach                                 |                                        +                                 |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |                                        +                                 |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |                                        +                                 |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |                                        +                                 |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Cyst                        |                                                                         X|             
      Capsule, Hyperplasia                 | 3  3  3  3  3  2     3  3  2  3  3  3  3  3  3  2  3  3  3  3  3  3  3  3|             
      Corticomedullary Junction, Cyst      |                                              X  X                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  14                                                               
NTP Experiment-Test: 05074-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  PENTACHLOROPHENOL, DOWICIDE EC7                              Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 14:47:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 2| 2| 2| 2| 3| 9| 2| 1| 2| 2| 2| 2| 3| 0| 3| 3| 2| 8| 3| 2| 2| 2| 2| 2|             
                                           | 0| 8| 8| 8| 7| 0| 9| 9| 1| 9| 8| 7| 7| 5| 6| 0| 0| 9| 9| 0| 7| 9| 9| 8| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    200 PPM                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypertrophy, Focal                   |                                                                          |             
      Hypertrophy                          |       2                    2           2                                 |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |                                        +                                 |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |                                        M                                 |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |                +     I                 +        +           +  +         |             
      Pars Distalis, Hyperplasia           |                                                 3           2            |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |                                        +                                 |             
      Follicle, Cyst                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   |          +                    +        +  +     +  +  +           +     +|             
      Hyperplasia, Tubular                 |                                                                          |             
      Inflammation, Chronic Active         |                                        4  4           4                  |             
      Follicle, Cyst                       |                               X           X                             X|             
      Periovarian Tissue, Cyst             |          X                                      X                 X     X|             
                                            __________________________________________________________________________|             
   Uterus                                  | +     +  +  +  +     +  +  +  +  +  +  +     +  +     +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                3                             2        3                  |             
      Endometrium, Hyperplasia, Cystic,    |                                                                          |             
           Glandular, Multifocal           | 3     3  3  3        3  3  3  3  3  3  3     2  3     3  3  3  2  4  3  4|             
      Endometrium, Hyperplasia, Cystic,    |                                                                          |             
           Multifocal, Reticulum Cell      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |                                        +                                 |             
      Femoral, Hyperplasia, Diffuse,       |                                                                          |             
          Neutrophil                       |                                                                          |             
      Femoral, Hyperplasia, Neutrophil     |                                        3                                 |             
      Femoral, Myelofibrosis               |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                +        +              M        +  +                    +|             
      Mesenteric, Hematopoietic Cell       |                                                                          |             
          Proliferation                    |                3        2                                                |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |                                        M        +                        |             
                                            __________________________________________________________________________|             
   Spleen                                  | +                 +     +           +  +  +        +        +            |             
      Hemorrhage                           |                   4                                                      |             
      Necrosis                             |                   4                                                      |             
      Red Pulp, Hematopoietic Cell         |                                                                          |             
          Proliferation, Diffuse           |                                     3  3  3                              |             
                                            __________________________________________________________________________|             
   Thymus                                  |                                        +  +                              |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  15                                                               
NTP Experiment-Test: 05074-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  PENTACHLOROPHENOL, DOWICIDE EC7                              Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 14:47:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 2| 2| 2| 2| 3| 9| 2| 1| 2| 2| 2| 2| 3| 0| 3| 3| 2| 8| 3| 2| 2| 2| 2| 2|             
                                           | 0| 8| 8| 8| 7| 0| 9| 9| 1| 9| 8| 7| 7| 5| 6| 0| 0| 9| 9| 0| 7| 9| 9| 8| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    200 PPM                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Inflammation, Acute                  |                                           3                              |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |                                     +  +                                 |             
                                            __________________________________________________________________________|             
   Skin                                    |                +     +                 +        +        +  +           +|             
      Alopecia                             |                X     X                          X        X              X|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |                                        +                                 |             
      Joint, Tarsal, Hyperostosis          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |                                        +                                 |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |                                        +                                 |             
      Interstitium, Inflammation, Chronic  |                                                                          |             
          Active                           |                                        3                                 |             
      Mediastinum, Inflammation, Acute     |                                        4                                 |             
                                            __________________________________________________________________________|             
   Nose                                    |                                        +                                 |             
      Glands, Inflammation, Acute, Focal   |                                        2                                 |             
      Olfactory Epithelium, Metaplasia,    |                                                                          |             
           Focal                           |                                        2                                 |             
                                            __________________________________________________________________________|             
   Trachea                                 |                                        +                                 |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                        M                                 |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |                                        +           +              +      |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |                                        +                                 |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  16                                                               
NTP Experiment-Test: 05074-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  PENTACHLOROPHENOL, DOWICIDE EC7                              Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 14:47:10  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 2| 0| 3| 3| 3| 3| 2| 1| 2| 3| 2| 3| 2| 2| 2| 2| 2| 2| 4| 3| 2| 2| 2| 2| 1|            |
                                           | 9| 7| 0| 0| 0| 6| 7| 4| 7| 0| 7| 1| 7| 8| 8| 9| 9| 6| 8| 0| 9| 7| 7| 8| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|      A     |
    200 PPM                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |                +     M           +                 +                     |   4        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |                +     A           +                 +                     |   3        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |                +     +           +                 +  A                  |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                +     A           +                    A                  |   3        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                +     +           +                    A                  |   4        |
      Parasite Metazoan                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                +     +           +                    A                  |   4        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                +     A           +                 +  A                  |   4        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                +     A           +                    A                  |   3        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                +     A           +                    A                  |   3        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                +     A           +                    A                  |   3        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  49        |
      Basophilic Focus                     |                                                             X            |      1     |
      Clear Cell Focus                     |    X                                                                     |      1     |
      Clear Cell Focus, Multiple           |                            X  X        X  X     X        X  X  X         |     12     |
      Degeneration, Cystic                 |       2                 2     2                 2           3            |      6  2.3|
      Hematopoietic Cell Proliferation,    |                                                                          |            |
           Multifocal                      |    2  2  2  2  3        2  2  2     2  2  2  2  2  2     2  2  1     2   |     35  2.1|
      Inflammation, Chronic Active, Diffuse| 1  2           2                       2  2  2  1  1     1  1  1        3|     29  1.4|
      Inflammation, Chronic Active, Focal  |                                  3                                       |      1  3.0|
      Pigmentation, Multifocal             | 2  2     2  1     2     2  2  2  2  1  1  2  2  2  2     2  2  1  2      |     32  1.8|
      Bile Duct, Cyst                      |                                                                          |      1     |
      Bile Duct, Cyst, Multiple            |                                                                          |      1     |
      Bile Duct, Hyperplasia, Multifocal   |                                  4                                       |      1  4.0|
      Hepatocyte, Cytomegaly, Diffuse      | 2  2  2  2  2  2  1  2  2  2  3  2  2  2  2  2  2  2     2  2  2  2  2  3|     49  2.0|
      Hepatocyte, Necrosis, Acute, Diffuse | 2  2  2  2  2  1  2  1  2  2  2  2  2  2  2  2  2  2     2  2  2  2  2  3|     49  1.9|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                +                                                         |   1        |
      Inflammation, Acute                  |                3                                                         |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                |       +        +     +           +                 +        +            |   7        |
      Duct, Ectasia                        |                                                             4            |      1  4.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                +     M           +                 +                     |   3        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |                +     +           +                 +  A                  |   5        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                +     +           +                 +  A                  |   5        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                +     +           +                 +  A                  |   5        |
                                            __________________________________________________________________________|____________|
   Tongue                                  |       +                                                                  |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |                +     +           +                 +                     |   5        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  17                                                               
NTP Experiment-Test: 05074-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  PENTACHLOROPHENOL, DOWICIDE EC7                              Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 14:47:10  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 2| 0| 3| 3| 3| 3| 2| 1| 2| 3| 2| 3| 2| 2| 2| 2| 2| 2| 4| 3| 2| 2| 2| 2| 1|            |
                                           | 9| 7| 0| 0| 0| 6| 7| 4| 7| 0| 7| 1| 7| 8| 8| 9| 9| 6| 8| 0| 9| 7| 7| 8| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|      A     |
    200 PPM                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A|  47        |
      Capsule, Cyst                        |                                                                          |      1     |
      Capsule, Hyperplasia                 | 2  2  3  3  3  3  2  2  3  3  3  3  3  2  3  3  3  2     2  2  3  3  2   |     47  2.7|
      Corticomedullary Junction, Cyst      |                                                                          |      2     |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A|  47        |
      Hypertrophy, Focal                   |                                  2                                       |      1  2.0|
      Hypertrophy                          |       3                                                              2   |      5  2.2|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  A  +  +  +  +  +  A|  46        |
      Hyperplasia                          |       2                             2                       2  2     2   |      5  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                +     +           +                 +                     |   5        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                +     M           +                 +                     |   3        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |                +     M           +     +           +                    A|   9        |
      Pars Distalis, Hyperplasia           |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                +     M           +                 +                     |   4        |
      Follicle, Cyst                       |                                  X                                       |      1     |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +           +  +     +           +        +        +                 +   |  17        |
      Hyperplasia, Tubular                 |             3                                                            |      1  3.0|
      Inflammation, Chronic Active         |                4                                                         |      4  4.0|
      Follicle, Cyst                       | X           X        X           X        X        X                 X   |     10     |
      Periovarian Tissue, Cyst             |                                           X                              |      5     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +     +  +  +  +  +  +  +  +     +  +  +  +  +     +     +  +  +  +  +   |  41        |
      Inflammation, Acute                  |                3                                                         |      4  2.8|
      Endometrium, Hyperplasia, Cystic,    |                                                                          |            |
           Glandular, Multifocal           | 3     3  3  2  2  4     2  3     3  4  2  3  3           3  4  3     3   |     37  3.0|
      Endometrium, Hyperplasia, Cystic,    |                                                                          |            |
           Multifocal, Reticulum Cell      |                                                                   3      |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                +     +           +                 +                     |   5        |
      Femoral, Hyperplasia, Diffuse,       |                                                                          |            |
          Neutrophil                       |                3                                                         |      1  3.0|
      Femoral, Hyperplasia, Neutrophil     |                                                                          |      1  3.0|
      Femoral, Myelofibrosis               |                                  4                                       |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  18                                                               
NTP Experiment-Test: 05074-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  PENTACHLOROPHENOL, DOWICIDE EC7                              Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 14:47:10  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 2| 0| 3| 3| 3| 3| 2| 1| 2| 3| 2| 3| 2| 2| 2| 2| 2| 2| 4| 3| 2| 2| 2| 2| 1|            |
                                           | 9| 7| 0| 0| 0| 6| 7| 4| 7| 0| 7| 1| 7| 8| 8| 9| 9| 6| 8| 0| 9| 7| 7| 8| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|      A     |
    200 PPM                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +     +        +     +           +                 +                     |  11        |
      Mesenteric, Hematopoietic Cell       |                                                                          |            |
          Proliferation                    |       2                                            2                     |      4  2.3|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                +                 +                 +                     |   4        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +     +     +  +     A        +  +     +        +  +                     |  17        |
      Hemorrhage                           |                                                                          |      1  4.0|
      Necrosis                             |                                                                          |      1  4.0|
      Red Pulp, Hematopoietic Cell         |                                                                          |            |
          Proliferation, Diffuse           |                3                       3                                 |      5  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  |                M     +           +                 +                     |   5        |
      Inflammation, Acute                  |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                +     +           +                 +                    +|   7        |
                                            __________________________________________________________________________|____________|
   Skin                                    |       +        +     +        +  +  +     +  +  +  +     +               |  18        |
      Alopecia                             |                                     X        X                           |      7     |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                +     +           +                 +                     |   5        |
      Joint, Tarsal, Hyperostosis          |                                                    X                     |      1     |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                +     +           +                 +                     |   5        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +              +     +           +                 +                     |   6        |
      Interstitium, Inflammation, Chronic  |                                                                          |            |
          Active                           |                                                                          |      1  3.0|
      Mediastinum, Inflammation, Acute     |                2                                                         |      2  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    |                +     +           +                 +                     |   5        |
      Glands, Inflammation, Acute, Focal   |                                  1                                       |      2  1.5|
      Olfactory Epithelium, Metaplasia,    |                                                                          |            |
           Focal                           |                                  2                                       |      2  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 |                +     M           +                 +                     |   4        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                +     +           M           +     +                     |   4        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  19                                                               
NTP Experiment-Test: 05074-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  PENTACHLOROPHENOL, DOWICIDE EC7                              Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 14:47:10  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 2| 0| 3| 3| 3| 3| 2| 1| 2| 3| 2| 3| 2| 2| 2| 2| 2| 2| 4| 3| 2| 2| 2| 2| 1|            |
                                           | 9| 7| 0| 0| 0| 6| 7| 4| 7| 0| 7| 1| 7| 8| 8| 9| 9| 6| 8| 0| 9| 7| 7| 8| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|      A     |
    200 PPM                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +              +     +           +                 +                     |   8        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                +     +           +                 +                     |   5        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  20                                                               
NTP Experiment-Test: 05074-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  PENTACHLOROPHENOL, DOWICIDE EC7                              Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 14:47:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 0| 2| 2| 2| 2| 3| 3| 2| 2| 2| 2| 2| 6| 2| 2| 2| 2| 2| 2| 7| 2| 8| 2| 2| 2|             
                                           | 2| 9| 9| 8| 7| 0| 0| 7| 7| 8| 7| 9| 8| 9| 9| 7| 9| 7| 8| 0| 9| 9| 9| 8| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    600 PPM                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Peyer's Patch, Hyperplasia, Lymphoid |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | A  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Peyer's Patch, Hyperplasia, Lymphoid |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Clear Cell Focus                     |                   X  X           X  X           X  X  X                 X|             
      Clear Cell Focus, Multiple           |    X  X     X           X              X                          X  X   |             
      Cytomegaly, Diffuse                  |                                                                          |             
      Degeneration, Cystic                 |                                                                          |             
      Hematopoietic Cell Proliferation,    |                                                                          |             
           Multifocal                      | 2  2  2  2  3  2  2  2  2  2  3  2  2  2  3  2  2  2  2     2  2  2  2  2|             
      Inflammation, Chronic Active, Diffuse| 2  2  2  2  1  2  2  2  1  2  2  2  2  2  1  2  2  2  2  2  2  2  2  2  2|             
      Pigmentation, Multifocal             | 2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2|             
      Bile Duct, Cyst                      |                                                                          |             
      Bile Duct, Hyperplasia, Multifocal   |    2     2  2  2  2  2  3  2  2     2  2  2  2  2  2  2  2  2     2  2  2|             
      Hepatocyte, Cytomegaly, Diffuse      | 2  3  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  3  2  3  2  3  3  3|             
      Hepatocyte, Necrosis, Acute, Diffuse | 2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2|             
                                            __________________________________________________________________________|             
   Mesentery                               |       +                                                                  |             
                                            __________________________________________________________________________|             
   Pancreas                                | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Hyperplasia, Lymphoid                |                               3                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Hyperplasia                 | 3  3  3  3  3  3  3  3  3  3  3  3  3  3  3  3  3  3  3  3  3  3  3  3  3|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Fatty                  |                                                 3                        |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    3  3  2  3  3           2     2  2              3     2               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  21                                                               
NTP Experiment-Test: 05074-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  PENTACHLOROPHENOL, DOWICIDE EC7                              Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 14:47:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 0| 2| 2| 2| 2| 3| 3| 2| 2| 2| 2| 2| 6| 2| 2| 2| 2| 2| 2| 7| 2| 8| 2| 2| 2|             
                                           | 2| 9| 9| 8| 7| 0| 0| 7| 7| 8| 7| 9| 8| 9| 9| 7| 9| 7| 8| 0| 9| 9| 9| 8| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    600 PPM                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | M  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Hyperplasia           |    2  3              2              2  3  2  3     2  2     2  2  2     2|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Ultimobranchial Cyst                 |                                           X                              |             
      Follicle, Cyst                       |       X                                                                  |             
      Follicular Cell, Hyperplasia         |                3                 2     2        3                        |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicle, Cyst                       |       X        X                    X  X     X                 X         |             
      Periovarian Tissue, Cyst             |                                                                      X   |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                          2               |             
      Endometrium, Hyperplasia, Cystic,    |                                                                          |             
           Glandular, Multifocal           |    3     2  2  3  2  2  2  3  3  2  2  2  2  3  3  2  3  2  2     3  3  3|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femoral, Myelofibrosis               |       2  2  2     3        2  2        2  2     2     3           3  2  2|             
                                            __________________________________________________________________________|             
   Lymph Node                              | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Lumbar, Hematopoietic Cell           |                                                                          |             
          Proliferation                    |                                                                          |             
      Mesenteric, Hematopoietic Cell       |                                                                          |             
          Proliferation                    |                      3     2                                             |             
      Mesenteric, Hematopoietic Cell       |                                                                          |             
          Proliferation, Multifocal        |                                           2                 3        2   |             
      Renal, Hematopoietic Cell            |                                                                          |             
          Proliferation                    |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Hyperplasia, Lymphoid                |                               3                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Depletion Lymphoid                   | 2                                                                        |             
      Hyperplasia, Lymphoid                |                               3                                          |             
      Red Pulp, Hematopoietic Cell         |                                                                          |             
          Proliferation, Diffuse           |                            2                                   4         |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  22                                                               
NTP Experiment-Test: 05074-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  PENTACHLOROPHENOL, DOWICIDE EC7                              Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 14:47:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 0| 2| 2| 2| 2| 3| 3| 2| 2| 2| 2| 2| 6| 2| 2| 2| 2| 2| 2| 7| 2| 8| 2| 2| 2|             
                                           | 2| 9| 9| 8| 7| 0| 0| 7| 7| 8| 7| 9| 8| 9| 9| 7| 9| 7| 8| 0| 9| 9| 9| 8| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    600 PPM                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +|             
      Hyperplasia, Cystic                  |    2     3  2  2  3  3  3     3  3  2  3  4     2  2              3  2   |             
                                            __________________________________________________________________________|             
   Skin                                    | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alopecia                             |                                  X                                       |             
      Ulcer                                |       4                                                                  |             
      Sebaceous Gland, Hyperplasia         |                                                                          |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic Active                  |       4                                                                  |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femur, Hyperostosis                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Meninges, Infiltration Cellular,     |                                                                          |             
           Lymphocyte                      |             2        2                                         2         |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                               3                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Glands, Inflammation, Acute, Focal   |    2  2  2  2  2  2  2  1  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2   |             
      Olfactory Epithelium, Metaplasia,    |                                                                          |             
           Focal                           |    2  2  2  2  2  2  2  1  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2   |             
                                            __________________________________________________________________________|             
   Trachea                                 | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | A  +  +  +  M  M  M  M  +  +  +  +  +  +  M  M  M  M  M  M  M  +  M  +  +|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infarct                              |    3                                                                     |             
      Nephropathy, Chronic                 |                                                                   2      |             
      Glomerulus, Inflammation, Chronic,   |                                                                          |             
           Diffuse                         |                                                                          |             
      Renal Tubule, Regeneration           |          2                             2        2  2                     |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  23                                                               
NTP Experiment-Test: 05074-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  PENTACHLOROPHENOL, DOWICIDE EC7                              Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 14:47:10  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 5| 5| 5| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4|            |
                             DAY ON TEST   | 2| 2| 3| 2| 2| 5| 1| 2| 2| 2| 1| 2| 5| 2| 2| 2| 3| 3| 3| 3| 1| 2| 2| 2| 8|            |
                                           | 9| 7| 0| 7| 8| 5| 6| 8| 8| 8| 1| 9| 3| 9| 8| 9| 0| 0| 0| 0| 2| 8| 8| 7| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    600 PPM                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  A  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  47        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  A  A  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +   |  42        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  45        |
      Peyer's Patch, Hyperplasia, Lymphoid |                                                 3                        |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  A  A  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +   |  44        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  45        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  46        |
      Peyer's Patch, Hyperplasia, Lymphoid |                                                 3                        |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  47        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  48        |
      Clear Cell Focus                     | X     X              X                 X                       X         |     13     |
      Clear Cell Focus, Multiple           |    X                       X              X  X     X     X               |     13     |
      Cytomegaly, Diffuse                  |                                        3                                 |      1  3.0|
      Degeneration, Cystic                 |                                                          2               |      1  2.0|
      Hematopoietic Cell Proliferation,    |                                                                          |            |
           Multifocal                      | 2  2  2  2  3     2  2  2  2     2     2  2  2  3  3  3  3  3  2  3  3   |     45  2.2|
      Inflammation, Chronic Active, Diffuse| 2  2  2  2  2     2  2  2  2  2  2     2  2  2  2  2  2  2  2  2  2  2   |     47  1.9|
      Pigmentation, Multifocal             | 2  2  2  2  2     2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2   |     48  2.0|
      Bile Duct, Cyst                      |                                           X        X                     |      2     |
      Bile Duct, Hyperplasia, Multifocal   | 2  2     2  2        2  2  2     2     2  2  2  2  2  2  2  2  2  2  2   |     40  2.0|
      Hepatocyte, Cytomegaly, Diffuse      | 3  3  3  3  3     3  3  3  3  3  3  3     2  3  3  3  2  2  3  3  3  3   |     47  2.5|
      Hepatocyte, Necrosis, Acute, Diffuse | 2  2  2  2  2     2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2   |     48  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |       +                                                                  |   2        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  46        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  46        |
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  47        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  47        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  47        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  48        |
      Inflammation, Chronic                |                                                                3         |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  24                                                               
NTP Experiment-Test: 05074-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  PENTACHLOROPHENOL, DOWICIDE EC7                              Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 14:47:10  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 5| 5| 5| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4|            |
                             DAY ON TEST   | 2| 2| 3| 2| 2| 5| 1| 2| 2| 2| 1| 2| 5| 2| 2| 2| 3| 3| 3| 3| 1| 2| 2| 2| 8|            |
                                           | 9| 7| 0| 7| 8| 5| 6| 8| 8| 8| 1| 9| 3| 9| 8| 9| 0| 0| 0| 0| 2| 8| 8| 7| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    600 PPM                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Capsule, Hyperplasia                 | 2  3  2  3  3  3  3  3  3  3  3  3  2  3  3  3  3  3  2  3  3  3  2  3   |     49  2.9|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Degeneration, Fatty                  |                            3                                             |      2  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Hyperplasia                          | 2           2                       3     3        3           2  2      |     17  2.5|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  46        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  M  M  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +   |  44        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  M  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  44        |
      Pars Distalis, Hyperplasia           |    3                                   3     3  3           2     3      |     19  2.4|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  A  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +   |  46        |
      Inflammation, Chronic                |                            3                                             |      1  3.0|
      Ultimobranchial Cyst                 |                                                                          |      1     |
      Follicle, Cyst                       |                         X                                                |      2     |
      Follicular Cell, Hyperplasia         |                            3                                             |      5  2.6|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  48        |
      Follicle, Cyst                       | X                    X  X           X     X                          X   |     12     |
      Periovarian Tissue, Cyst             |                                                    X        X            |      3     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  47        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Endometrium, Hyperplasia, Cystic,    |                                                                          |            |
           Glandular, Multifocal           | 3  3  2  2           2  2  3     3        3  2  2  2  3  3  2  2  2  3   |     40  2.5|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  48        |
      Femoral, Myelofibrosis               |    2                 2           3           2  2  2                 3   |     20  2.3|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  M  +  +  M  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  44        |
      Lumbar, Hematopoietic Cell           |                                                                          |            |
          Proliferation                    |                   3                                                      |      1  3.0|
      Mesenteric, Hematopoietic Cell       |                                                                          |            |
          Proliferation                    |                   3                       3                              |      4  2.8|
      Mesenteric, Hematopoietic Cell       |                                                                          |            |
          Proliferation, Multifocal        |                                                                          |      3  2.3|
      Renal, Hematopoietic Cell            |                                                                          |            |
          Proliferation                    |                   3                                                      |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  25                                                               
NTP Experiment-Test: 05074-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  PENTACHLOROPHENOL, DOWICIDE EC7                              Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 14:47:10  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 5| 5| 5| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4|            |
                             DAY ON TEST   | 2| 2| 3| 2| 2| 5| 1| 2| 2| 2| 1| 2| 5| 2| 2| 2| 3| 3| 3| 3| 1| 2| 2| 2| 8|            |
                                           | 9| 7| 0| 7| 8| 5| 6| 8| 8| 8| 1| 9| 3| 9| 8| 9| 0| 0| 0| 0| 2| 8| 8| 7| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    600 PPM                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  M  +  +  M  A  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M   |  42        |
      Hyperplasia, Lymphoid                |                                                 3                        |      2  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  47        |
      Depletion Lymphoid                   |                                                                          |      1  2.0|
      Hyperplasia, Lymphoid                |                                                 3                        |      2  3.0|
      Red Pulp, Hematopoietic Cell         |                                                                          |            |
          Proliferation, Diffuse           |             4     3                                         4            |      5  3.4|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  M  M  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +   |  43        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  +  +  +  +  M  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +   |  40        |
      Hyperplasia, Cystic                  |    3  3  2              3  3  3  2  2  3  3     3     2     2     3  2   |     31  2.6|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  46        |
      Alopecia                             |                                                                   X      |      2     |
      Ulcer                                |                                                                          |      1  4.0|
      Sebaceous Gland, Hyperplasia         |                                           3                              |      1  3.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Chronic Active                  |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Femur, Hyperostosis                  |                   X                                                      |      1     |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  47        |
      Meninges, Infiltration Cellular,     |                                                                          |            |
           Lymphocyte                      |                                        2              2                  |      5  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  48        |
      Hyperplasia, Lymphoid                |                                                 3                        |      2  3.0|
      Alveolar Epithelium, Hyperplasia     |    2                                                                     |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  48        |
      Glands, Inflammation, Acute, Focal   | 2  2  2  2  2  1     2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2   |     46  2.0|
      Olfactory Epithelium, Metaplasia,    |                                                                          |            |
           Focal                           | 2  2  2  2  2  1     2  2  2  2  2     2  2  2  2  2  2  2  2  2  2  2   |     45  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  A  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  46        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  26                                                               
NTP Experiment-Test: 05074-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  PENTACHLOROPHENOL, DOWICIDE EC7                              Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 14:47:10  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 5| 5| 5| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4|            |
                             DAY ON TEST   | 2| 2| 3| 2| 2| 5| 1| 2| 2| 2| 1| 2| 5| 2| 2| 2| 3| 3| 3| 3| 1| 2| 2| 2| 8|            |
                                           | 9| 7| 0| 7| 8| 5| 6| 8| 8| 8| 1| 9| 3| 9| 8| 9| 0| 0| 0| 0| 2| 8| 8| 7| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    600 PPM                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +  M  M  M  +  +  M  M  +  M  +  M  +  M  +  M  M  +  M  +  +  M  M  +   |  23        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  48        |
      Infarct                              |                                                                          |      1  3.0|
      Nephropathy, Chronic                 |                                                          2        4      |      3  2.7|
      Glomerulus, Inflammation, Chronic,   |                                                                          |            |
           Diffuse                         |             3                                                            |      1  3.0|
      Renal Tubule, Regeneration           |                                                       2                  |      5  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +   |  47        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  27                                                               
NTP Experiment-Test: 05074-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  PENTACHLOROPHENOL, DOWICIDE EC7                              Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 14:47:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 4| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 2| 7| 4| 1|             
                             DAY ON TEST   | 2| 2| 2| 3| 2| 5| 2| 9| 2| 2| 2| 3| 2| 2| 2| 2| 8| 3| 2| 2| 2| 2| 1| 7| 9|             
                                           | 8| 7| 9| 0| 7| 4| 9| 8| 9| 9| 9| 0| 7| 9| 9| 9| 1| 0| 9| 8| 7| 4| 0| 1| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    0 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  A  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  A|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  A|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                             X            |             
      Hematopoietic Cell Proliferation,    |                                                                          |             
           Multifocal                      |                                                       2                  |             
      Infarct                              |                         4                                               2|             
      Inflammation, Acute                  |                                  2                                       |             
      Bile Duct, Hyperplasia, Multifocal   |                         4                                                |             
      Hepatocyte, Necrosis, Acute, Focal   |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |          3                                                               |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                   2                                                      |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Ulcer, Acute                         |                                                                      3   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                   2      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Ectopic Tissue              |                                                    X           X         |             
      Capsule, Hyperplasia                 | 2  2  2  2        2  1  2  2  3  4  2  2  2  2  2  3     2  2  2  2  2   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hyperplasia                          | 3           2  2  2                                               2      |             
      Hypertrophy                          |                                        2           2                     |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                         2                                                |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  +  +  +  +  M  +  +  +  +  M  M  M  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  M  +  +  M  +  I  +  +  +  +  +  +  +  +  +  +  M  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  28                                                               
NTP Experiment-Test: 05074-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  PENTACHLOROPHENOL, DOWICIDE EC7                              Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 14:47:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 4| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 2| 7| 4| 1|             
                             DAY ON TEST   | 2| 2| 2| 3| 2| 5| 2| 9| 2| 2| 2| 3| 2| 2| 2| 2| 8| 3| 2| 2| 2| 2| 1| 7| 9|             
                                           | 8| 7| 9| 0| 7| 4| 9| 8| 9| 9| 9| 0| 7| 9| 9| 9| 1| 0| 9| 8| 7| 4| 0| 1| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    0 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Distalis, Cyst                  |                                           X                              |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicle, Cyst                       |                         X                                                |             
      Follicular Cell, Hyperplasia         |                            2                                             |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Penis                                   |                +     +                                         +        +|             
      Inflammation, Chronic Active         |                3                                               3        3|             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                +     +                                                   |             
      Inflammation, Chronic Active         |                                                                          |             
      Duct, Dilatation                     |                3     3                                                   |             
                                            __________________________________________________________________________|             
   Prostate                                |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                             3            |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                                                             +            |             
      Inflammation, Chronic Active         |                                                             4            |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                 3                        |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |    +                          +                       +                  |             
      Neutrophilia                         |    X                          X                       X                  |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femoral, Hyperplasia, Neutrophil     |    3                                                                 3   |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +|             
      Lumbar, Hyperplasia, Lymphoid        |                                                                         3|             
      Mesenteric, Hematopoietic Cell       |                                                                          |             
          Proliferation                    |       3                          3                    3                  |             
      Mesenteric, Hematopoietic Cell       |                                                                          |             
          Proliferation, Multifocal        |    3                                                                     |             
      Pancreatic, Inflammation, Chronic    |                                                                          |             
          Active                           |                                                             2            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                             2            |             
      Depletion Lymphoid                   |                      3                          2              3        3|             
      Red Pulp, Hematopoietic Cell         |                                                                          |             
          Proliferation, Diffuse           |    3                                                  3        3     2  3|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  M  +  +  +  M  +  +  +  +  M  +  I  +  M     M  M  +  M  M  M  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  29                                                               
NTP Experiment-Test: 05074-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  PENTACHLOROPHENOL, DOWICIDE EC7                              Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 14:47:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 4| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 2| 7| 4| 1|             
                             DAY ON TEST   | 2| 2| 2| 3| 2| 5| 2| 9| 2| 2| 2| 3| 2| 2| 2| 2| 8| 3| 2| 2| 2| 2| 1| 7| 9|             
                                           | 8| 7| 9| 0| 7| 4| 9| 8| 9| 9| 9| 0| 7| 9| 9| 9| 1| 0| 9| 8| 7| 4| 0| 1| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    0 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +|             
      Acanthosis                           |             2              2                                            2|             
      Alopecia                             |    X        X              X                                X            |             
      Inflammation, Acute                  | 3                                                                        |             
      Metaplasia, Focal, Osseous           |                                                                          |             
      Necrosis                             |                                                                      4   |             
      Ulcer                                |                                                                         2|             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic Active                  |                                                                      3   |             
      Subcutaneous Tissue, Lymphatic,      |                                                                          |             
          Dilatation                       |                                              3  2                        |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Joint, Tarsal, Hyperostosis          | X  X  X  X  X           X  X  X        X  X     X  X  X  X               |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                          |             
      Meninges, Infiltration Cellular,     |                                                                          |             
           Lymphocyte                      | 2                                                                        |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar Epithelium, Hyperplasia     |                                           2                              |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Glands, Inflammation, Acute, Focal   |    2                                         1                           |             
      Olfactory Epithelium, Metaplasia,    |                                                                          |             
           Focal                           |    2                                         2                           |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  M  +  +  +  +  M  +  +  +  +  M  +  +  M  M  +  +  +  +  +  +  +  +  M|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydronephrosis                       |                                                             4            |             
      Infarct                              |                                                             4            |             
      Inflammation, Chronic Active         |                                                       4     3            |             
      Nephropathy, Chronic                 |    2                                                                     |             
      Capsule, Fibrosis                    |                                              1                           |             
      Renal Tubule, Dilatation             |                2                                               3        3|             
      Renal Tubule, Regeneration           | 2     2     2     2        2  2        2  2  2           2           2   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  30                                                               
NTP Experiment-Test: 05074-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  PENTACHLOROPHENOL, DOWICIDE EC7                              Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 14:47:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 4| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 2| 7| 4| 1|             
                             DAY ON TEST   | 2| 2| 2| 3| 2| 5| 2| 9| 2| 2| 2| 3| 2| 2| 2| 2| 8| 3| 2| 2| 2| 2| 1| 7| 9|             
                                           | 8| 7| 9| 0| 7| 4| 9| 8| 9| 9| 9| 0| 7| 9| 9| 9| 1| 0| 9| 8| 7| 4| 0| 1| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    0 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Urethra                                 |                +                                                        +|             
      Calculus Micro Observation Only      |                                                                         X|             
      Inflammation, Chronic Active         |                3                                                         |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +|             
      Calculus Micro Observation Only      |                                                                          |             
      Dilatation                           |                3     4                                         4        3|             
      Inflammation, Chronic Active         |                                                                          |             
      Mucosa, Hyperplasia                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  31                                                               
NTP Experiment-Test: 05074-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  PENTACHLOROPHENOL, DOWICIDE EC7                              Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 14:47:10  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 7| 5| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 6| 0| 2| 2| 2| 2| 2| 2| 2|                                            |            |
                                           | 0| 8| 5| 9| 8| 8| 8| 9| 9| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|                                            |      A     |
    0 PPM                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  35        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  A  +  +  +  +  +  +  +  +                                             |  30        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +                                             |  34        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  32        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  34        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  M  +  +  +  +  +  +  +  +                                             |  31        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +                                             |  33        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  M  +  +  +  +  +  +  +  +                                             |  31        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  M  +  +  +  +  +  +  +  +                                             |  30        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  32        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  35        |
      Basophilic Focus                     |                                                                          |      1     |
      Hematopoietic Cell Proliferation,    |                                                                          |            |
           Multifocal                      |                                                                          |      1  2.0|
      Infarct                              |                                                                          |      2  3.0|
      Inflammation, Acute                  |                                                                          |      1  2.0|
      Bile Duct, Hyperplasia, Multifocal   |                                                                          |      1  4.0|
      Hepatocyte, Necrosis, Acute, Focal   |                      2                                                   |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  M  +  +  +  +  +  +  +  +                                             |  34        |
      Acinus, Atrophy                      |                1                                                         |      2  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  35        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  M  +  +  +  +  +  +  +  +                                             |  33        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  M  +  +  +  +  +  +  +  +                                             |  33        |
      Inflammation, Acute                  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  M  +  +  +  +  +  +  +  +                                             |  33        |
      Ulcer, Acute                         |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  35        |
      Mineralization                       |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  A  +  +  +  +  +  +  +  +                                             |  34        |
      Capsule, Ectopic Tissue              |             X                                                            |      3     |
      Capsule, Hyperplasia                 | 3     3  2  2  2  2  2  3  2                                             |     30  2.2|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  A  +  +  +  +  +  +  +  +                                             |  34        |
      Cyst                                 |          X                                                               |      1     |
      Hyperplasia                          |                            2                                             |      6  2.2|
      Hypertrophy                          | 1                          2                                             |      4  1.8|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  32                                                               
NTP Experiment-Test: 05074-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  PENTACHLOROPHENOL, DOWICIDE EC7                              Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 14:47:10  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 7| 5| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 6| 0| 2| 2| 2| 2| 2| 2| 2|                                            |            |
                                           | 0| 8| 5| 9| 8| 8| 8| 9| 9| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|                                            |      A     |
    0 PPM                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  A  +  +  +  +  +  +  +  +                                             |  34        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  M  +  +  +  +  +  +  +  +                                             |  34        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  +  +  +  M  +  +  +  +                                             |  28        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  M  +  +  +  +  M  +  +  +                                             |  29        |
      Pars Distalis, Cyst                  |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  35        |
      Follicle, Cyst                       |                                                                          |      1     |
      Follicular Cell, Hyperplasia         |          2        2                                                      |      3  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  35        |
                                            __________________________________________________________________________|____________|
   Penis                                   | +           +                                                            |   6        |
      Inflammation, Chronic Active         |                                                                          |      3  3.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |             +                                                            |   3        |
      Inflammation, Chronic Active         |             4                                                            |      1  4.0|
      Duct, Dilatation                     |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +                                             |  34        |
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                                                                          |   1        |
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  35        |
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   3        |
      Neutrophilia                         |                                                                          |      3     |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  35        |
      Femoral, Hyperplasia, Neutrophil     |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  I  +  +  +  +  +  +  +  +                                             |  31        |
      Lumbar, Hyperplasia, Lymphoid        |                                                                          |      1  3.0|
      Mesenteric, Hematopoietic Cell       |                                                                          |            |
          Proliferation                    |       2                 3                                                |      5  2.8|
      Mesenteric, Hematopoietic Cell       |                                                                          |            |
          Proliferation, Multifocal        |                                                                          |      1  3.0|
      Pancreatic, Inflammation, Chronic    |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  33                                                               
NTP Experiment-Test: 05074-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  PENTACHLOROPHENOL, DOWICIDE EC7                              Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 14:47:10  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 7| 5| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 6| 0| 2| 2| 2| 2| 2| 2| 2|                                            |            |
                                           | 0| 8| 5| 9| 8| 8| 8| 9| 9| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|                                            |      A     |
    0 PPM                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
          Active                           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  I  +  +  +  +  +  +  +  +                                             |  31        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  A  +  +  +  +  +  +  +  +                                             |  34        |
      Angiectasis                          |                                                                          |      1  2.0|
      Depletion Lymphoid                   |       3                                                                  |      5  2.8|
      Red Pulp, Hematopoietic Cell         |                                                                          |            |
          Proliferation, Diffuse           |                                                                          |      5  2.8|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  M  +  +  M  +  +  +  M  +                                             |  21        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M                                             |            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  34        |
      Acanthosis                           |                                                                          |      3  2.0|
      Alopecia                             |                         X                                                |      5     |
      Inflammation, Acute                  |                                                                          |      1  3.0|
      Metaplasia, Focal, Osseous           |          2                                                               |      1  2.0|
      Necrosis                             |                                                                          |      1  4.0|
      Ulcer                                |          3                                                               |      2  2.5|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Chronic Active                  |          3                                                               |      2  3.0|
      Subcutaneous Tissue, Lymphatic,      |                                                                          |            |
          Dilatation                       | 3                                                                        |      3  2.7|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  35        |
      Joint, Tarsal, Hyperostosis          | X        X           X  X                                                |     18     |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  35        |
      Cyst Epithelial Inclusion            |    X                                                                     |      1     |
      Meninges, Infiltration Cellular,     |                                                                          |            |
           Lymphocyte                      |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  35        |
      Alveolar Epithelium, Hyperplasia     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  35        |
      Glands, Inflammation, Acute, Focal   | 1     1                                                                  |      4  1.3|
      Olfactory Epithelium, Metaplasia,    |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  34                                                               
NTP Experiment-Test: 05074-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  PENTACHLOROPHENOL, DOWICIDE EC7                              Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 14:47:10  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 7| 5| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 6| 0| 2| 2| 2| 2| 2| 2| 2|                                            |            |
                                           | 0| 8| 5| 9| 8| 8| 8| 9| 9| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|                                            |      A     |
    0 PPM                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
           Focal                           |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  35        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +  +  M  M  +  +  +  +  +  +                                             |  27        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  35        |
      Hydronephrosis                       |                                                                          |      1  4.0|
      Infarct                              |                                                                          |      1  4.0|
      Inflammation, Chronic Active         |             4                                                            |      3  3.7|
      Nephropathy, Chronic                 |                                                                          |      1  2.0|
      Capsule, Fibrosis                    |                                                                          |      1  1.0|
      Renal Tubule, Dilatation             |                                                                          |      3  2.7|
      Renal Tubule, Regeneration           |                         2                                                |     12  2.0|
                                            __________________________________________________________________________|____________|
   Urethra                                 |             +                                                            |   3        |
      Calculus Micro Observation Only      |             X                                                            |      2     |
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  33        |
      Calculus Micro Observation Only      |             X                                                            |      1     |
      Dilatation                           |             3                                                            |      5  3.4|
      Inflammation, Chronic Active         |             2                                                            |      1  2.0|
      Mucosa, Hyperplasia                  |             3                                                            |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  35                                                               
NTP Experiment-Test: 05074-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  PENTACHLOROPHENOL, DOWICIDE EC7                              Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 14:47:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 4| 2| 6| 7| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 5| 5| 7| 7| 7|             
                             DAY ON TEST   | 9| 7| 5| 1| 2| 5| 2| 2| 2| 2| 1| 3| 5| 0| 2| 2| 2| 5| 3| 2| 1| 6| 2| 2| 2|             
                                           | 5| 7| 4| 3| 7| 9| 9| 8| 8| 8| 1| 0| 5| 5| 9| 8| 8| 9| 0| 9| 3| 8| 7| 8| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6|             
    100 PPM                                | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    A  M  +                    +                             +  +         |             
                                            __________________________________________________________________________|             
   Gallbladder                             |    A  A  A                    +                             A  +         |             
                                            __________________________________________________________________________|             
   Intestine Large                         |    A  +  +                    +                             A  +         |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    A  M  M                    +                             A  +         |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    A  +  +                    +                             A  +         |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    A  M  A                    +                             A  M         |             
                                            __________________________________________________________________________|             
   Intestine Small                         |    A  +  +                    +                             A  +         |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    A  A  +                    +                             A            |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    A  +  +                    +                             A            |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    A  +  +                    +                             A            |             
                                            __________________________________________________________________________|             
   Liver                                   | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Basophilic Focus                     |                                                                          |             
      Clear Cell Focus                     |                                                                      X   |             
      Clear Cell Focus, Multiple           |             X        X  X                    X  X        X        X     X|             
      Degeneration, Cystic                 |                                                                          |             
      Hematopoietic Cell Proliferation,    |                                                                          |             
           Diffuse                         |                                                                          |             
      Hematopoietic Cell Proliferation,    |                                                                          |             
           Multifocal                      |             2  2  2     2  2  2  2     2              2           2  2  2|             
      Hyperplasia, Focal                   |                                                                          |             
      Infarct                              |                                                                          |             
      Inflammation, Chronic Active, Diffuse| 2        2  1  2        2  2  1  1     2  1  2  1  2  2  2        2  2  2|             
      Pigmentation, Multifocal             | 2        2  2  2  2  1  2  2  1  2     2  2  2  2  2  2  2        2  2  2|             
      Thrombosis, Multiple                 |                X                                                         |             
      Bile Canaliculi, Hyperplasia,        |                                                                          |             
          Atypical, Diffuse                |                                                                          |             
      Bile Duct, Cyst                      |                                  X                                       |             
      Bile Duct, Cyst, Multiple            |                                        X                                 |             
      Bile Duct, Hyperplasia, Multifocal   |                                                    2                     |             
      Hepatocyte, Cytomegaly, Diffuse      | 3     1  3  2  2  2  3  2  3  3  2  2  3  2  2  3  2  2  2     1  2  2  2|             
      Hepatocyte, Necrosis, Acute, Diffuse | 3     1  2  2  2  2  2  3  3  2  2  2  3  2  2  2  2  2  2     1  2  2  2|             
                                            __________________________________________________________________________|             
   Pancreas                                |    A  +  +                    +                             A  +         |             
      Acinus, Atrophy                      |                                                                          |             
      Duct, Ectasia                        |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    A  M  +                    +                             +  +         |             
                                            __________________________________________________________________________|             
   Stomach                                 |    A  +  +                    +                             A  +         |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    A  +  +                    +                             A  +         |             
      Acanthosis                           |                                                                          |             
      Hyperkeratosis                       |                                                                          |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    A  +  +                    +                             A  +         |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +  +  +                    +                             +  +         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  36                                                               
NTP Experiment-Test: 05074-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  PENTACHLOROPHENOL, DOWICIDE EC7                              Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 14:47:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 4| 2| 6| 7| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 5| 5| 7| 7| 7|             
                             DAY ON TEST   | 9| 7| 5| 1| 2| 5| 2| 2| 2| 2| 1| 3| 5| 0| 2| 2| 2| 5| 3| 2| 1| 6| 2| 2| 2|             
                                           | 5| 7| 4| 3| 7| 9| 9| 8| 8| 8| 1| 0| 5| 5| 9| 8| 8| 9| 0| 9| 3| 8| 7| 8| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6|             
    100 PPM                                | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Capsule, Hyperplasia                 |       2  2  2     1  2     2  2  2     2  2  2  2  2  2  2     2  2  2  2|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Cytoplasmic Alteration               |                      2                                                   |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia                          |                                                 2  2  2                  |             
      Hypertrophy                          |                   2           2                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Hyperplasia                          | 2              2  2  2                    2     2                 2  2  2|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    A  +  +                    +                             A  +         |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    A  M  M                    +                             +  +         |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    M  M  +                    +                             M  +         |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    A  M  +                    +                             +  +         |             
      Follicular Cell, Hypertrophy         |          2                                                               |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |    +  +  +                    +                             +  +         |             
      Spermatocele                         |                                                             X            |             
                                            __________________________________________________________________________|             
   Penis                                   |                         +  +                          +                 +|             
      Inflammation, Chronic Active         |                         2                                                |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |    +                                                  +        +         |             
      Dilatation                           |                                                                3         |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic Active         |    4                                                                     |             
      Duct, Dilatation                     |                                                       3                  |             
                                            __________________________________________________________________________|             
   Prostate                                |    A  +  +                    +                             A  +         |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                            +                                +            |             
      Dilatation                           |                                                             2            |             
      Inflammation, Chronic Active         |                            3                                             |             
                                            __________________________________________________________________________|             
   Testes                                  |    +  +  +                    +                             A  +         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    A  +  +                    +                             A  +         |             
      Femoral, Hyperplasia, Diffuse,       |                                                                          |             
          Neutrophil                       |       3                                                                  |             
      Femoral, Hyperplasia, Neutrophil     |                               3                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    A  M  M                 +  +        +                    +  M         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  37                                                               
NTP Experiment-Test: 05074-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  PENTACHLOROPHENOL, DOWICIDE EC7                              Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 14:47:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 4| 2| 6| 7| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 5| 5| 7| 7| 7|             
                             DAY ON TEST   | 9| 7| 5| 1| 2| 5| 2| 2| 2| 2| 1| 3| 5| 0| 2| 2| 2| 5| 3| 2| 1| 6| 2| 2| 2|             
                                           | 5| 7| 4| 3| 7| 9| 9| 8| 8| 8| 1| 0| 5| 5| 9| 8| 8| 9| 0| 9| 3| 8| 7| 8| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6|             
    100 PPM                                | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Angiectasis                          |                                        3                                 |             
      Hyperplasia, Plasma Cell             |                                                                          |             
      Mesenteric, Hematopoietic Cell       |                                                                          |             
          Proliferation                    |                            3                                             |             
      Mesenteric, Hematopoietic Cell       |                                                                          |             
          Proliferation, Multifocal        |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |    A  M  M                    +                             +  M         |             
                                            __________________________________________________________________________|             
   Spleen                                  |    A  +  +                 +  +        +                    A  +        +|             
      Cyst                                 |                            X                                             |             
      Depletion Lymphoid                   |                                                                2         |             
      Red Pulp, Hematopoietic Cell         |                                                                          |             
          Proliferation, Diffuse           |          4                    4        4                                2|             
                                            __________________________________________________________________________|             
   Thymus                                  |    M  M  M                    M                             A  M         |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    M  M  M                    M                             M  M         |             
                                            __________________________________________________________________________|             
   Skin                                    | +  A  +  +  +     +  +     +  +  +     +  +  +        +  +  +  +  +      |             
      Acanthosis                           |                                                                          |             
      Alopecia                             |                   X           X              X           X        X      |             
      Cyst Epithelial Inclusion            |                                                                          |             
      Hyperkeratosis                       |                                  3                                       |             
      Ulcer                                | 4                    3     2  4  3                                       |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic                         |                            3                                             |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic Active                  |                      3        3                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +  +  +  +     +  +     +  +  +  +     +     +  +  +     +  +         |             
      Joint, Tarsal, Hyperostosis          |             X     X  X     X  X  X  X     X     X  X  X                  |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                       +                  |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    A  +  +                    +                             +  +         |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |    +  +  +                    +  +                    +     +  +         |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                  3                                       |             
                                            __________________________________________________________________________|             
   Nose                                    |    +  +  +                    +                             +  +         |             
      Glands, Inflammation, Acute, Focal   |       2                                                                  |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute, Focal                    |       2                                                                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  38                                                               
NTP Experiment-Test: 05074-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  PENTACHLOROPHENOL, DOWICIDE EC7                              Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 14:47:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 4| 2| 6| 7| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 5| 5| 7| 7| 7|             
                             DAY ON TEST   | 9| 7| 5| 1| 2| 5| 2| 2| 2| 2| 1| 3| 5| 0| 2| 2| 2| 5| 3| 2| 1| 6| 2| 2| 2|             
                                           | 5| 7| 4| 3| 7| 9| 9| 8| 8| 8| 1| 0| 5| 5| 9| 8| 8| 9| 0| 9| 3| 8| 7| 8| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6|             
    100 PPM                                | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Olfactory Epithelium, Metaplasia,    |                                                                          |             
           Focal                           |       1                                                                  |             
                                            __________________________________________________________________________|             
   Trachea                                 |    A  M  +                    +                             +  +         |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Cornea, Hyperplasia, Focal           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |    +  M  +                    +                          +  A  +         |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    A  +  +     +  +           +           +                 A  +         |             
      Hydronephrosis                       |                                                                          |             
      Inflammation, Acute                  |                4                                                         |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                             +            |             
      Calculus Micro Observation Only      |                                                             X            |             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    A  +  +                    +                             A  +         |             
      Dilatation                           |                                                                          |             
      Inflammation, Acute                  |       2                                                                  |             
      Mucosa, Hyperplasia                  |       3                                                                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  39                                                               
NTP Experiment-Test: 05074-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  PENTACHLOROPHENOL, DOWICIDE EC7                              Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 14:47:10  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 3| 6| 7| 4| 7| 4| 5| 6| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4|            |
                             DAY ON TEST   | 1| 0| 9| 2| 3| 2| 4| 3| 1| 2| 2| 3| 2| 6| 3| 2| 2| 2| 2| 2| 9| 2| 2| 2| 8|            |
                                           | 2| 5| 0| 9| 1| 7| 0| 2| 2| 8| 3| 0| 7| 3| 0| 8| 7| 9| 7| 7| 7| 8| 8| 7| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9|      A     |
    100 PPM                                | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |    +        +     +  +  +              +                                +|  11        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |    +        A     A  +  A              +                                A|   5        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |    +        +     +  +  +              A                                +|  10        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |    +        A     M  +  +              A                                A|   5        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |    +        +     +  +  +              A                                +|  10        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |    +        A     +  +  +              A                                +|   6        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |    +        A     M  +  +              A                                A|   7        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |    +        A     M  +  +              A                                A|   5        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |    +        A     M  +  +              A                                A|   6        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |    +        A     M  +  +              A                                A|   6        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Basophilic Focus                     |                X  X        X                                             |      3     |
      Clear Cell Focus                     |          X                                                               |      2     |
      Clear Cell Focus, Multiple           |                X           X     X  X     X     X  X     X        X      |     17     |
      Degeneration, Cystic                 |                               3                                2         |      2  2.5|
      Hematopoietic Cell Proliferation,    |                                                                          |            |
           Diffuse                         |                                                             4            |      1  4.0|
      Hematopoietic Cell Proliferation,    |                                                                          |            |
           Multifocal                      | 2        2              2  2              2           2           2  2   |     20  2.0|
      Hyperplasia, Focal                   |          3                                                     3         |      2  3.0|
      Infarct                              |                               4                                          |      1  4.0|
      Inflammation, Chronic Active, Diffuse| 2        2     2  2  2  2  2  2  2  2     2  1  1  2  1  1     2     1   |     36  1.7|
      Pigmentation, Multifocal             | 2        2     2  2  2  2  2  2  2  2     2  2  2  2  2  2  2  2  2  2   |     40  2.0|
      Thrombosis, Multiple                 |                                                                          |      1     |
      Bile Canaliculi, Hyperplasia,        |                                                                          |            |
          Atypical, Diffuse                |                            4                                             |      1  4.0|
      Bile Duct, Cyst                      |                      2                                                   |      2  2.0|
      Bile Duct, Cyst, Multiple            |                                                                      X   |      2     |
      Bile Duct, Hyperplasia, Multifocal   |          2                                                     2         |      3  2.0|
      Hepatocyte, Cytomegaly, Diffuse      | 3  2  2  3  2  2  1  1  2  3  2  3  3  1  2  3  3  3  2  2  2  3  2  2  1|     48  2.2|
      Hepatocyte, Necrosis, Acute, Diffuse | 2  1  1  3  2  2  1  1  2  2  2  2  2  1  2  2  2  2  2  2  2  2  2  2   |     47  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                |    +        +     +  +  +              +                          +     +|  12        |
      Acinus, Atrophy                      |                      2                                                   |      1  2.0|
      Duct, Ectasia                        |                                                                   4      |      1  4.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |    +        +     +  +  +              +                                +|  11        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |    +        +     +  +  +              +                                +|  11        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |    +        +     +  +  +              +                                +|  11        |
      Acanthosis                           |                         3                                                |      1  3.0|
      Hyperkeratosis                       |                                                                         3|      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  40                                                               
NTP Experiment-Test: 05074-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  PENTACHLOROPHENOL, DOWICIDE EC7                              Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 14:47:10  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 3| 6| 7| 4| 7| 4| 5| 6| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4|            |
                             DAY ON TEST   | 1| 0| 9| 2| 3| 2| 4| 3| 1| 2| 2| 3| 2| 6| 3| 2| 2| 2| 2| 2| 9| 2| 2| 2| 8|            |
                                           | 2| 5| 0| 9| 1| 7| 0| 2| 2| 8| 3| 0| 7| 3| 0| 8| 7| 9| 7| 7| 7| 8| 8| 7| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9|      A     |
    100 PPM                                | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Ulcer                                |                         2                                                |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |    +        +     +  +  +              +                                +|  11        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |    +        +     +  +  +              +                                +|  13        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Capsule, Hyperplasia                 | 2        2     2     2  1  2     2  2     2     2  2  2  2  2     2      |     34  1.9|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Cytoplasmic Alteration               |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |                                                             2            |      1  2.0|
      Hyperplasia                          |                                     2        2  2  2                     |      7  2.0|
      Hypertrophy                          |                                                                3         |      3  2.3|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hyperplasia                          | 2        2                 2  3  2  2              2     2     2     2   |     19  2.1|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |    +        +     +  +  +              +                                +|  11        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |    +        +     +  +  +              +                                +|  10        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |    +        +     M  +  +              +                                +|   9        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |    +        +     +  +  +              +                                +|  11        |
      Follicular Cell, Hypertrophy         |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |    +        +     +  +  +              +                                +|  13        |
      Spermatocele                         |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Penis                                   | +        +                                                               |   6        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +     +                                +                          +   |   8        |
      Dilatation                           |                                                                          |      1  3.0|
      Hyperplasia                          |    2                                                                     |      1  2.0|
      Inflammation, Chronic Active         | 3  3     2                                2                          3   |      6  2.8|
      Duct, Dilatation                     |                                           4                              |      2  3.5|
                                            __________________________________________________________________________|____________|
   Prostate                                |    +        +     +  +  +              +                                +|  11        |
      Inflammation, Acute                  |             2                                                            |      1  2.0|
      Inflammation, Chronic Active         |    2                                                                     |      1  2.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |    +                                                                     |   3        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  41                                                               
NTP Experiment-Test: 05074-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  PENTACHLOROPHENOL, DOWICIDE EC7                              Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 14:47:10  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 3| 6| 7| 4| 7| 4| 5| 6| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4|            |
                             DAY ON TEST   | 1| 0| 9| 2| 3| 2| 4| 3| 1| 2| 2| 3| 2| 6| 3| 2| 2| 2| 2| 2| 9| 2| 2| 2| 8|            |
                                           | 2| 5| 0| 9| 1| 7| 0| 2| 2| 8| 3| 0| 7| 3| 0| 8| 7| 9| 7| 7| 7| 8| 8| 7| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9|      A     |
    100 PPM                                | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Dilatation                           |    3                                                                     |      2  2.5|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Testes                                  |    +        +     +  +  +              +                                +|  12        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |    +        +     +  +  +              +                                A|  10        |
      Femoral, Hyperplasia, Diffuse,       |                                                                          |            |
          Neutrophil                       |                                                                          |      1  3.0|
      Femoral, Hyperplasia, Neutrophil     |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  M        +     +  +  +  +           +                 +           +  +|  14        |
      Angiectasis                          |                                                                          |      1  3.0|
      Hyperplasia, Plasma Cell             | 2                                                                        |      1  2.0|
      Mesenteric, Hematopoietic Cell       |                                                                          |            |
          Proliferation                    |                      3     2                                         2   |      4  2.5|
      Mesenteric, Hematopoietic Cell       |                                                                          |            |
          Proliferation, Multifocal        |                                                          2               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |    M        +     +  +  +              +                                +|   8        |
                                            __________________________________________________________________________|____________|
   Spleen                                  |    +        +  +  +  +  +  +           +     +              +        +  +|  19        |
      Cyst                                 |                                                                          |      1     |
      Depletion Lymphoid                   |    2                                                                    3|      3  2.3|
      Red Pulp, Hematopoietic Cell         |                                                                          |            |
          Proliferation, Diffuse           |    2           4        3                                   4            |      8  3.4|
                                            __________________________________________________________________________|____________|
   Thymus                                  |    +        +     M  +  +              +                                M|   5        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |    M        M     M  M  M              M                                M|            |
                                            __________________________________________________________________________|____________|
   Skin                                    |    +        +  +  +  +  +  +           +        +  +  +  +        +  +  +|  32        |
      Acanthosis                           |                3                                                  3  3   |      3  3.0|
      Alopecia                             |                X           X                             X               |      8     |
      Cyst Epithelial Inclusion            |                                                    X                     |      1     |
      Hyperkeratosis                       |                                                                          |      1  3.0|
      Ulcer                                |                                                                          |      5  3.2|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Chronic                         |                                                                          |      1  3.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Chronic Active                  |                                                          3               |      3  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +     +  +  +  +  +        +  +  +  +  +     +  +  +  +  +  +     +|  36        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  42                                                               
NTP Experiment-Test: 05074-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  PENTACHLOROPHENOL, DOWICIDE EC7                              Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 14:47:10  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 3| 6| 7| 4| 7| 4| 5| 6| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4|            |
                             DAY ON TEST   | 1| 0| 9| 2| 3| 2| 4| 3| 1| 2| 2| 3| 2| 6| 3| 2| 2| 2| 2| 2| 9| 2| 2| 2| 8|            |
                                           | 2| 5| 0| 9| 1| 7| 0| 2| 2| 8| 3| 0| 7| 3| 0| 8| 7| 9| 7| 7| 7| 8| 8| 7| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9|      A     |
    100 PPM                                | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
      Joint, Tarsal, Hyperostosis          | X     X        X  X  X           X  X     X  X     X  X  X  X  X  X      |     26     |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |    +        +     +  +  +              +                                +|  12        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |    +        +     +  +  +              +                                +|  15        |
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                                                                         2|      1  2.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    |    +        +     +  +  +              +                                +|  13        |
      Glands, Inflammation, Acute, Focal   |                                                                          |      1  2.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Acute, Focal                    |                                                                          |      1  2.0|
      Olfactory Epithelium, Metaplasia,    |                                                                          |            |
           Focal                           |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 |    +        +     +  +  +              +                                +|  11        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     | +                                                                        |   1        |
      Cornea, Hyperplasia, Focal           | 3                                                                        |      1  3.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |    +        +     +  +  +              +                                +|  12        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |    +        +     +  +  +              +                                +|  14        |
      Hydronephrosis                       |             3                                                            |      1  3.0|
      Inflammation, Acute                  |             2                                                            |      2  3.0|
                                            __________________________________________________________________________|____________|
   Urethra                                 |             +                                                            |   2        |
      Calculus Micro Observation Only      |                                                                          |      1     |
      Inflammation, Acute                  |             3                                                            |      1  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +        +     +  +  +              A                                +|  11        |
      Dilatation                           | 3  3        3                                                            |      3  3.0|
      Inflammation, Acute                  |                                                                          |      1  2.0|
      Mucosa, Hyperplasia                  |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  43                                                               
NTP Experiment-Test: 05074-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  PENTACHLOROPHENOL, DOWICIDE EC7                              Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 14:47:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 3| 3| 7| 6| 1| 3| 7| 7| 5| 7| 2| 2| 7| 2| 2|             
                             DAY ON TEST   | 8| 1| 2| 3| 2| 3| 2| 2| 3| 3| 2| 5| 2| 6| 4| 1| 2| 3| 9| 2| 9| 9| 2| 9| 9|             
                                           | 1| 6| 9| 0| 7| 0| 9| 8| 0| 0| 4| 2| 7| 0| 0| 5| 7| 0| 8| 9| 3| 2| 7| 3| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|             
    200 PPM                                | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +                          +  +        +  +        A     +  +     A  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             |    +                          +  A        +  +        A     A  A     A  A|             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +                          +  +        +  +        A     +  +     A  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +                          +  A        M  +        A     A  +     A  A|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +                          +  +        +  +        A     +  +     A  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +                          +  +        M  +        A     A  M     A  A|             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +                          +  +        M  +        A     A  +     A  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    A                          +  A        M  +        A     A  +     A  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    A                          +  A        M  +        A     A  +     A  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +                          +  +        M  +        A     A  +     A  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +|             
      Clear Cell Focus, Multiple           |          X  X     X  X  X  X                    X  X     X        X      |             
      Degeneration, Cystic                 |                                                          3               |             
      Hematopoietic Cell Proliferation,    |                                                                          |             
           Multifocal                      | 2     2  2                                      2        2        2      |             
      Hyperplasia, Focal                   |                3                                                         |             
      Infarct                              |                                                                          |             
      Inflammation, Chronic Active, Diffuse| 2  2  2  1  2  2  2  1  1  1  2  2  2  2     1  3  2     2  1  1  2     2|             
      Pigmentation, Multifocal             | 3  2  2  2     2  2  1  2  2  2  2  2  2        2  2     2        2      |             
      Bile Duct, Cyst                      |                   4                                      X               |             
      Bile Duct, Cyst, Multifocal          |                                                                          |             
      Bile Duct, Hyperplasia, Multifocal   |       2           2  2                                                   |             
      Hepatocyte, Cytomegaly, Diffuse      | 2  2  3  3  3  2  3  2  2  3  2  3  3  2  2  2  3  3     2  3  2  3     2|             
      Hepatocyte, Necrosis, Acute, Diffuse | 2  2  2  2  2  2  2  2  2  2  2  2  2  2  1  1  2  2     2  2  2  3     2|             
                                            __________________________________________________________________________|             
   Pancreas                                |    +                          +  M        +  +        A     +  +     M  +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +                          +  +        +  +        A     +  +     A  +|             
                                            __________________________________________________________________________|             
   Stomach                                 |    +                          +  +        +  +        A     A  +     A  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +                          +  +        +  +        A     A  +     A  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +                          +  +        +  +        A     A  +     A  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +                          +  +        +  +        +     +  +     +  +|             
      Degeneration, Chronic                |                                                                2         |             
      Atrium, Thrombosis                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
      Capsule, Hyperplasia                 | 2  2  2  2  2  2     2  2  2  2  2  2  2     1  2  2                     |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  A  +|             
      Hyperplasia                          |                                                                          |             
      Hypertrophy                          | 2        2     2                                                         |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  A  +|             
      Hyperplasia                          | 2  2     1     2        2  2                    2                        |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +                          +  M        +  +        A     +  +     M  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  44                                                               
NTP Experiment-Test: 05074-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  PENTACHLOROPHENOL, DOWICIDE EC7                              Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 14:47:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 3| 3| 7| 6| 1| 3| 7| 7| 5| 7| 2| 2| 7| 2| 2|             
                             DAY ON TEST   | 8| 1| 2| 3| 2| 3| 2| 2| 3| 3| 2| 5| 2| 6| 4| 1| 2| 3| 9| 2| 9| 9| 2| 9| 9|             
                                           | 1| 6| 9| 0| 7| 0| 9| 8| 0| 0| 4| 2| 7| 0| 0| 5| 7| 0| 8| 9| 3| 2| 7| 3| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|             
    200 PPM                                | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    +                          +  +        M  +        M     M  M     M  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +                          +  +        +  +        M     I  +     M  +|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +                          +  +        +  +        M     M  +     A  +|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |    +                          +  +        +  +        +     +  +     +  +|             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |    +              +                          +                           |             
      Inflammation, Chronic Active         |    2              4                          3                           |             
                                            __________________________________________________________________________|             
   Prostate                                |    +                          +  +        +  +        M     M  +     +  +|             
      Inflammation, Acute                  |    2                          2              3                           |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  |    +                          +  +        +  +        +     +  +     +  +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
      Neutrophilia                         |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +                          +  +        +  +        A     A  A     A  +|             
      Femoral, Hyperplasia, Neutrophil     |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +        +                 +  +  +     +  +        M     +  +     +  M|             
      Mesenteric, Hematopoietic Cell       |                                                                          |             
          Proliferation                    |             3                       3                                    |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |    +                          +  +        +  +        M     +  +     +  M|             
      Depletion Lymphoid                   |                                                                          |             
      Necrosis                             |                                              2                           |             
                                            __________________________________________________________________________|             
   Spleen                                  |    +                          +  +        +  +  +     A     A  +     A  +|             
      Depletion Lymphoid                   |    3                          2  2           2                 3        2|             
      Necrosis                             |                                           3                              |             
      Red Pulp, Hematopoietic Cell         |                                                                          |             
          Proliferation, Diffuse           |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |    +                          +  +        M  +        M     M  +     A  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    M                          M  M        M  M        M     M  M     M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +                          I  +        +  +  +  +  A  +  +  +     +  +|             
      Acanthosis                           |                                                                          |             
      Alopecia                             |                                                                          |             
      Inflammation, Chronic Active         |                                                          3               |             
      Ulcer, Focal                         | 3                                                                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  45                                                               
NTP Experiment-Test: 05074-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  PENTACHLOROPHENOL, DOWICIDE EC7                              Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 14:47:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 3| 3| 7| 6| 1| 3| 7| 7| 5| 7| 2| 2| 7| 2| 2|             
                             DAY ON TEST   | 8| 1| 2| 3| 2| 3| 2| 2| 3| 3| 2| 5| 2| 6| 4| 1| 2| 3| 9| 2| 9| 9| 2| 9| 9|             
                                           | 1| 6| 9| 0| 7| 0| 9| 8| 0| 0| 4| 2| 7| 0| 0| 5| 7| 0| 8| 9| 3| 2| 7| 3| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|             
    200 PPM                                | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Ulcer                                |                                                          2               |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Acute                           |    4                                                                     |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic Active                  | 3                                                                        |             
      Subcutaneous Tissue, Necrosis, Acute |                                           2                              |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +           +              +  +        +  +  +     +  +  +  +     +  +|             
      Joint, Tarsal, Hyperostosis          | X              X                                X     X  X               |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +                          +  +        +  +        A     +  +     +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |    +                          +  +  +     +  +        +  +  +  +     +  +|             
                                            __________________________________________________________________________|             
   Nose                                    |    +                          +  +        M  +        +     +  +     +  +|             
      Glands, Inflammation, Acute, Focal   |                                                             1            |             
      Olfactory Epithelium, Atrophy        |                                                             1            |             
      Olfactory Epithelium, Metaplasia,    |                                                                          |             
           Focal                           |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 |    +                          +  +        +  +        A     +  +     A  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |    +                          M  +        M  +        +     +  +     +  +|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +                       +  +  +        +  +        A     +  +     +  +|             
      Hydronephrosis                       |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Pelvis, Inflammation, Acute          |                                           3                              |             
      Renal Tubule, Dilatation, Diffuse    |                                              3                           |             
      Renal Tubule, Dilatation             |    2                                                                     |             
      Renal Tubule, Metaplasia, Osseous    |    2                                                                     |             
      Renal Tubule, Mineralization         |                               2                                          |             
                                            __________________________________________________________________________|             
   Urethra                                 |    +                          +  +                                      +|             
      Calculus Micro Observation Only      |                                  X                                      X|             
      Inflammation, Acute                  |    3                          3  4                                       |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +                          +  +        +  +        A     A  +     A  +|             
      Dilatation                           |    4                          3              4                 3        3|             
      Inflammation, Chronic Active         |                                           3                              |             
      Mucosa, Hyperplasia                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  46                                                               
NTP Experiment-Test: 05074-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  PENTACHLOROPHENOL, DOWICIDE EC7                              Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 14:47:10  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 1| 6| 7| 5| 7| 7| 3| 7| 0| 7| 7| 7| 7| 6| 6| 7| 7| 7| 5| 7| 7|            |
                             DAY ON TEST   | 5| 2| 2| 2| 3| 9| 2| 4| 2| 2| 4| 2| 2| 2| 2| 3| 2| 0| 0| 2| 3| 2| 7| 2| 3|            |
                                           | 1| 9| 9| 9| 4| 0| 9| 1| 7| 8| 2| 7| 6| 9| 8| 0| 7| 8| 3| 7| 0| 8| 8| 9| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5|      A     |
    200 PPM                                | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +           +        +        M     +              +  +           +      |  15        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +           +        +        A     +              A  A           +      |   9        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +           +        +        +     +              +  +           +      |  16        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | M           +        +        +     M              M  +           +      |   9        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +           +        +        +     +              +  +           +      |  16        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +           A        +        M     M              M  +           +      |   8        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +           +        +        +     +              M  +           +      |  13        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +           +        +        +     +              M  +           +      |  11        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +           A        +        +     M              M  +           +      |   8        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +           +        +        +     M              M  +           +      |  12        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Clear Cell Focus, Multiple           |       X  X        X     X        X     X  X              X     X     X  X|     21     |
      Degeneration, Cystic                 |                                                                          |      1  3.0|
      Hematopoietic Cell Proliferation,    |                                                                          |            |
           Multifocal                      |    2  2  2        2     2  3                 2  2           2           2|     16  2.1|
      Hyperplasia, Focal                   |                                              3        3                  |      3  3.0|
      Infarct                              |                      4                                                   |      1  4.0|
      Inflammation, Chronic Active, Diffuse| 2  2  1  2     1  2     2  2  2  2     2  1  2  2  2  3  1  1  1  2  1  2|     44  1.7|
      Pigmentation, Multifocal             |    2  2  2        2     2  2  2  2     2  2  2  2  2  2  2  2  2  2  2  2|     37  2.0|
      Bile Duct, Cyst                      |          X                                                               |      3  4.0|
      Bile Duct, Cyst, Multifocal          |                                                                   X  X   |      2     |
      Bile Duct, Hyperplasia, Multifocal   |                         2                    2                           |      5  2.0|
      Hepatocyte, Cytomegaly, Diffuse      | 3  3  3  2  2  2  2  3  3  3  2  2  1  3  2  3  3  3  3  3  2  2  3  2  2|     48  2.5|
      Hepatocyte, Necrosis, Acute, Diffuse | 3  2  2  2  1  1  2  2  2  3  3  2     2  2  2  2  3  3  2  2  2  2  2  2|     47  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +           +        +        M     +              +  +           +      |  14        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +           +        +        M     +              +  +           +      |  15        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +           +        +        +     +              +  +           +      |  15        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +           +        +        +     +              +  +           +      |  15        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +           +        +        +     +              +  +           +      |  15        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +           +        +        M     +              +  +           +      |  17        |
      Degeneration, Chronic                |                                                                          |      1  2.0|
      Atrium, Thrombosis                   |                                                       X                  |      1     |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Capsule, Hyperplasia                 |    2  1  2        2  2  2  2  2  2     2  2           2  2  2  2  3  2  2|     34  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  47                                                               
NTP Experiment-Test: 05074-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  PENTACHLOROPHENOL, DOWICIDE EC7                              Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 14:47:10  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 1| 6| 7| 5| 7| 7| 3| 7| 0| 7| 7| 7| 7| 6| 6| 7| 7| 7| 5| 7| 7|            |
                             DAY ON TEST   | 5| 2| 2| 2| 3| 9| 2| 4| 2| 2| 4| 2| 2| 2| 2| 3| 2| 0| 0| 2| 3| 2| 7| 2| 3|            |
                                           | 1| 9| 9| 9| 4| 0| 9| 1| 7| 8| 2| 7| 6| 9| 8| 0| 7| 8| 3| 7| 0| 8| 8| 9| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5|      A     |
    200 PPM                                | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia                          |                         2                                                |      1  2.0|
      Hypertrophy                          |          2                                2                    2         |      6  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hyperplasia                          |                2           2     2                 2        2        2   |     13  1.9|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +           +        +        M     +              +  +           +      |  14        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +           +        +        M     M  +           +  +           +      |  11        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +           +        +        M     +              +  +           +      |  14        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +           +        +        M     +              +  +           +      |  14        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +           +        +        +     +              +  +           +      |  18        |
                                            __________________________________________________________________________|____________|
   Penis                                   |                                     +                                    |   1        |
      Inflammation, Chronic Active         |                                     3                                    |      1  3.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                         +                                                |   4        |
      Inflammation, Chronic Active         |                         3                                                |      4  3.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +           +        +        +     +              M  +           +      |  15        |
      Inflammation, Acute                  |                                                                          |      3  2.3|
      Inflammation, Chronic Active         |                                     2                                    |      1  2.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                                     +                 +                  |   2        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +           +        +        +     +              +  +           +      |  18        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                    +                     |   1        |
      Neutrophilia                         |                                                    X                     |      1     |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +           +        +        +     +              +  +           +      |  14        |
      Femoral, Hyperplasia, Neutrophil     |                                                    4                     |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +        M  +  +  +  +     M     M        +  +  +  +  +        +      |  22        |
      Mesenteric, Hematopoietic Cell       |                                                                          |            |
          Proliferation                    |    2                 3  3                    3  2  3     3        3      |     10  2.8|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +           M        +        M     M              +  +           +      |  13        |
      Depletion Lymphoid                   |                                                    3                     |      1  3.0|
      Necrosis                             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +           +  +  +  +     +  M     +        +     +  +           +     +|  20        |
      Depletion Lymphoid                   |                                                                          |      6  2.3|
      Necrosis                             |                                                                          |      1  3.0|
      Red Pulp, Hematopoietic Cell         |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  48                                                               
NTP Experiment-Test: 05074-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  PENTACHLOROPHENOL, DOWICIDE EC7                              Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 14:47:10  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 1| 6| 7| 5| 7| 7| 3| 7| 0| 7| 7| 7| 7| 6| 6| 7| 7| 7| 5| 7| 7|            |
                             DAY ON TEST   | 5| 2| 2| 2| 3| 9| 2| 4| 2| 2| 4| 2| 2| 2| 2| 3| 2| 0| 0| 2| 3| 2| 7| 2| 3|            |
                                           | 1| 9| 9| 9| 4| 0| 9| 1| 7| 8| 2| 7| 6| 9| 8| 0| 7| 8| 3| 7| 0| 8| 8| 9| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5|      A     |
    200 PPM                                | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
          Proliferation, Diffuse           | 4                          4        2              3  4           3     4|      7  3.4|
                                            __________________________________________________________________________|____________|
   Thymus                                  | M           +        +        M     +              +  M           +      |  11        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M           M        M        M     M              M  M           M      |            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +           +     +  +     +  +  +  +           +  +  +     +     +     +|  26        |
      Acanthosis                           |                                  2                                       |      1  2.0|
      Alopecia                             |                                                 X           X            |      2     |
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Ulcer, Focal                         |                                                                          |      1  3.0|
      Ulcer                                |                   3                                4                    4|      4  3.3|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Acute                           |             4                                                            |      2  4.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Chronic Active                  |                                  2  3           4                       3|      5  3.0|
      Subcutaneous Tissue, Necrosis, Acute |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +        +  +  +     +        +     +        +  +  +  +  +        +  +  +|  29        |
      Joint, Tarsal, Hyperostosis          |          X     X                             X  X  X     X        X  X  X|     14     |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +           +        +        M     +              +  +           +      |  16        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +           +        +        M     +              +  +           +      |  19        |
                                            __________________________________________________________________________|____________|
   Nose                                    | +           +        +        +     M              +  +           +      |  16        |
      Glands, Inflammation, Acute, Focal   |                                                       2           2      |      3  1.7|
      Olfactory Epithelium, Atrophy        |                                                                          |      1  1.0|
      Olfactory Epithelium, Metaplasia,    |                                                                          |            |
           Focal                           |                                                       2           2      |      2  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +           +        +        M     +              +  +           +      |  15        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +           +        +        M     M              +  M           +      |  13        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +           +     +  +        +     +              +  +           +     +|  20        |
      Hydronephrosis                       |                   3                                                      |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  49                                                               
NTP Experiment-Test: 05074-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  PENTACHLOROPHENOL, DOWICIDE EC7                              Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 14:47:10  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 7| 1| 6| 7| 5| 7| 7| 3| 7| 0| 7| 7| 7| 7| 6| 6| 7| 7| 7| 5| 7| 7|            |
                             DAY ON TEST   | 5| 2| 2| 2| 3| 9| 2| 4| 2| 2| 4| 2| 2| 2| 2| 3| 2| 0| 0| 2| 3| 2| 7| 2| 3|            |
                                           | 1| 9| 9| 9| 4| 0| 9| 1| 7| 8| 2| 7| 6| 9| 8| 0| 7| 8| 3| 7| 0| 8| 8| 9| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5|      A     |
    200 PPM                                | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Acute                  |             2                                                            |      1  2.0|
      Inflammation, Chronic Active         |                   3                                                     4|      2  3.5|
      Pelvis, Inflammation, Acute          |                                                                          |      1  3.0|
      Renal Tubule, Dilatation, Diffuse    |                                                                          |      1  3.0|
      Renal Tubule, Dilatation             |                                     2                                    |      2  2.0|
      Renal Tubule, Metaplasia, Osseous    |                                                                          |      1  2.0|
      Renal Tubule, Mineralization         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urethra                                 |                                                                          |   4        |
      Calculus Micro Observation Only      |                                                                          |      2     |
      Inflammation, Acute                  |                                                                          |      3  3.3|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +           +  +     +        +     +              A  +           +      |  15        |
      Dilatation                           |             4  3                    4                                    |      8  3.5|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Mucosa, Hyperplasia                  |                                     2                                    |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  50                                                               
NTP Experiment-Test: 05074-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  PENTACHLOROPHENOL, DOWICIDE EC7                              Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 14:47:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 3| 7| 7| 7| 0| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 0| 0| 2| 3| 2| 6| 2| 2| 3| 5| 3| 2| 2| 3| 3| 3| 2| 2| 2| 2| 2| 2| 2| 3| 0|             
                                           | 8| 4| 7| 0| 9| 5| 7| 9| 0| 7| 0| 9| 8| 5| 0| 0| 8| 8| 8| 8| 8| 8| 8| 0| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8|             
    600 PPM                                | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             |    +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Prolapse                             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +  +  +  +  +  +  +  +  M  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                                          |             
      Clear Cell Focus                     |    X                                                                     |             
      Clear Cell Focus, Multiple           |       X     X        X  X                 X           X           X     X|             
      Hematopoietic Cell Proliferation,    |                                                                          |             
           Multifocal                      |    2  2  2  2  3  2  2  2     2  2  2  2  2  2  2  2  3  2  2  2  2  2   |             
      Infarct                              |                                                                         4|             
      Inflammation, Chronic Active, Diffuse|    2  2  2  2     1  2  2     2  2  3  2  2  2  2  2  2  2  2  2  2  2   |             
      Pigmentation, Multifocal             |    2  2  2  2  2  2  2  2     2  2  2  2  2  2  2  2  2  2  2  2  2  2   |             
      Bile Duct, Cyst                      |                                              X                           |             
      Bile Duct, Hyperplasia, Multifocal   |    2  2  2  2        2  2     2  2           2  2  2  2  2  2  2     2   |             
      Hepatocyte, Cytomegaly, Diffuse      |    3  3  3  3  3  3  3  3  2  3  3  3  3  3  3  3  3  3  3  3  3  3  3  3|             
      Hepatocyte, Necrosis, Acute, Diffuse |    2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2   |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Degeneration                 |                                                                          |             
      Acinus, Inflammation, Chronic        |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dysplasia                            |                               2                             2            |             
                                            __________________________________________________________________________|             
   Tooth                                   |    +                                                                     |             
      Developmental Malformation           |    X                                                                     |             
      Peridontal Tissue, Inflammation,     |                                                                          |             
           Chronic Active                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrium, Thrombosis                   |                                        X                                 |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  51                                                               
NTP Experiment-Test: 05074-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  PENTACHLOROPHENOL, DOWICIDE EC7                              Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 14:47:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 3| 7| 7| 7| 0| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 0| 0| 2| 3| 2| 6| 2| 2| 3| 5| 3| 2| 2| 3| 3| 3| 2| 2| 2| 2| 2| 2| 2| 3| 0|             
                                           | 8| 4| 7| 0| 9| 5| 7| 9| 0| 7| 0| 9| 8| 5| 0| 0| 8| 8| 8| 8| 8| 8| 8| 0| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8|             
    600 PPM                                | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Hyperplasia                 |    2           2        2           2  2  2  2  2  2        2  2         |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                2                                                         |             
      Hypertrophy                          |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                2                                                         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    +  +  +  +  +  M  +  M  M  M  +  +  +  M  +  M  +  +  +  +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +  +  +  +  +  +  +  +  M  +  M  +  M  M  M  M  +  M  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Hyperplasia         |                      1                                      1            |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granuloma Sperm                      |                                                                         2|             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                   +      |             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                                           +     +                        |             
      Inflammation, Chronic Active         |                                           3     3                        |             
      Duct, Dilatation                     |                                                 4                        |             
                                            __________________________________________________________________________|             
   Prostate                                |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Germinal Epithelium, Degeneration    |                2                                                         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesenteric, Hematopoietic Cell       |                                                                          |             
          Proliferation                    |       3                                   2              2               |             
      Mesenteric, Hyperplasia, Lymphoid    |                                                          3               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Lymphoid                   |                                                                          |             
      Red Pulp, Hematopoietic Cell         |                                                                          |             
          Proliferation, Diffuse           |                                        4                                4|             
                                            __________________________________________________________________________|             
   Thymus                                  |    +  +  M  M  +  M  M  +  M  M  +  +  M  +  +  +  M  +  +  M  M  M  +  M|             
      Necrosis, Acute                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  52                                                               
NTP Experiment-Test: 05074-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  PENTACHLOROPHENOL, DOWICIDE EC7                              Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 14:47:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 3| 7| 7| 7| 0| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 0| 0| 2| 3| 2| 6| 2| 2| 3| 5| 3| 2| 2| 3| 3| 3| 2| 2| 2| 2| 2| 2| 2| 3| 0|             
                                           | 8| 4| 7| 0| 9| 5| 7| 9| 0| 7| 0| 9| 8| 5| 0| 0| 8| 8| 8| 8| 8| 8| 8| 0| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8|             
    600 PPM                                | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                      2  2        3                                3      |             
      Alopecia                             |          X  X     X  X              X  X  X                 X     X      |             
      Ulcer                                |          4                                                               |             
      Subcutaneous Tissue, Fibrosis        |                         2                                                |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Acute                           |          3                                                               |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic Active                  |                                  3                                       |             
      Subcutaneous Tissue, Mineralization  |                                                                          |             
      Subcutaneous Tissue, Lymphatic,      |                                                                          |             
          Dilatation                       |                      3                                                   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Joint, Tarsal, Hyperostosis          |                         X        X           X        X     X  X  X  X   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Alveolar Epithelium, Bronchiole,     |                                                                          |             
           Hyperplasia                     |                                  2                                       |             
      Peribronchiolar, Glands,             |                                                                          |             
          Inflammation, Acute              |                                                                          |             
      Perivascular, Infiltration Cellular, |                                                                          |             
           Lymphocyte                      |                                                             2            |             
                                            __________________________________________________________________________|             
   Nose                                    |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Glands, Inflammation, Acute, Focal   |    2  2  2  2  1  2  2  2     2  2  2  2  2  2  2  2  2  2  2  2  2  2  1|             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute, Focal                    |                                                                          |             
      Olfactory Epithelium, Metaplasia,    |                                                                          |             
           Focal                           |    2  2  2  2  2  2  2  2     2  2  2  2  2  2  2  2  2  2  2  2  2  2   |             
                                            __________________________________________________________________________|             
   Trachea                                 |    +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                      +                                                   |             
      Lens, Cataract                       |                      2                                                   |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |    +  +  +  +  +  +  +  +  M  M  M  +  M  +  +  +  +  +  M  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  53                                                               
NTP Experiment-Test: 05074-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  PENTACHLOROPHENOL, DOWICIDE EC7                              Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 14:47:10  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 3| 7| 7| 7| 0| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 0| 0| 2| 3| 2| 6| 2| 2| 3| 5| 3| 2| 2| 3| 3| 3| 2| 2| 2| 2| 2| 2| 2| 3| 0|             
                                           | 8| 4| 7| 0| 9| 5| 7| 9| 0| 7| 0| 9| 8| 5| 0| 0| 8| 8| 8| 8| 8| 8| 8| 0| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8|             
    600 PPM                                | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic Active         |                      3                                                   |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                      X                    X                 X        X   |             
      Nephropathy, Chronic                 |                                                                   2      |             
      Renal Tubule, Dilatation             |                                                                          |             
      Renal Tubule, Regeneration           |    2     2     2  2  2  2     2  2  2              2                     |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                            4           4                                 |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  54                                                               
NTP Experiment-Test: 05074-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  PENTACHLOROPHENOL, DOWICIDE EC7                              Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 14:47:10  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 7| 2| 7| 7| 6| 4| 7| 7| 6| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 9| 2| 1| 5| 2| 2| 1| 5| 2| 2| 8| 3| 2| 3| 2| 3| 7| 2| 2| 3| 2| 2| 3| 1|            |
                                           | 6| 5| 9| 1| 3| 9| 8| 1| 8| 9| 7| 0| 0| 8| 0| 8| 0| 9| 7| 8| 0| 7| 9| 0| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      T     |
                               ANIMAL ID   | 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1|      A     |
    600 PPM                                | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  47        |
      Prolapse                             |                                                          X               |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Basophilic Focus                     |                                  X                    X                  |      2     |
      Clear Cell Focus                     |       X                                                     X  X         |      4     |
      Clear Cell Focus, Multiple           |                            X        X  X  X  X        X              X   |     15     |
      Hematopoietic Cell Proliferation,    |                                                                          |            |
           Multifocal                      |    2     2     2     2     2     2  2     2  2  2  2  2  2  2  2  2  2  2|     40  2.1|
      Infarct                              |                                                                         3|      2  3.5|
      Inflammation, Chronic Active, Diffuse| 2  2  2  2  2  2     2  2  2     2  2  2  2  2  2  2  2     2  2  2  2  2|     43  2.0|
      Pigmentation, Multifocal             | 2  2  2  2  2  2     2  2  2     2  2  2  2  2  2  2  2  2  2  2  2  2  2|     45  2.0|
      Bile Duct, Cyst                      |                                                                          |      1     |
      Bile Duct, Hyperplasia, Multifocal   |    2     2     2     2     2        2  2  2  2  2     2  2  3  2     2  2|     32  2.0|
      Hepatocyte, Cytomegaly, Diffuse      | 3  3  3  3  2  3     3  3  3     3  3  3  3  3  3  3  3  3  3  3  3  3  3|     47  3.0|
      Hepatocyte, Necrosis, Acute, Diffuse | 2  2  2  2  2  2     2  2  2     2  2  2  2  2  2  2  2  2  2  2  2  2  2|     46  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Acinus, Degeneration                 |                                                             3            |      1  3.0|
      Acinus, Inflammation, Chronic        |                                                             2            |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Acanthosis                           |                            3                                3            |      2  3.0|
      Inflammation, Chronic Active         |                                                             3            |      1  3.0|
      Ulcer                                |                            3                                             |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Dysplasia                            |                                                                   2      |      3  2.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                 +     +                  |   3        |
      Developmental Malformation           |                                                                          |      1     |
      Peridontal Tissue, Inflammation,     |                                                                          |            |
           Chronic Active                  |                                                 4     3                  |      2  3.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  55                                                               
NTP Experiment-Test: 05074-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  PENTACHLOROPHENOL, DOWICIDE EC7                              Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 14:47:10  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 7| 2| 7| 7| 6| 4| 7| 7| 6| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 9| 2| 1| 5| 2| 2| 1| 5| 2| 2| 8| 3| 2| 3| 2| 3| 7| 2| 2| 3| 2| 2| 3| 1|            |
                                           | 6| 5| 9| 1| 3| 9| 8| 1| 8| 9| 7| 0| 0| 8| 0| 8| 0| 9| 7| 8| 0| 7| 9| 0| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      T     |
                               ANIMAL ID   | 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1|      A     |
    600 PPM                                | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atrium, Thrombosis                   |                                                                         X|      2     |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Capsule, Hyperplasia                 | 2  2  2     2  2     2  2  2     2     2  2     2  2  2        2  2  2  2|     29  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |                                                                          |      1  2.0|
      Hypertrophy                          |                            3                                             |      1  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  41        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  I  +  M  +  +  +  +  +  +  +|  38        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Follicular Cell, Hyperplasia         |                                                                          |      2  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Granuloma Sperm                      |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Penis                                   |                                        +        +        +               |   4        |
      Inflammation, Acute                  |                                                 3                        |      1  3.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                                        +                 +               |   4        |
      Inflammation, Chronic Active         |                                        3                 2               |      4  2.8|
      Duct, Dilatation                     |                                                          3               |      2  3.5|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |             +                                                            |   1        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Germinal Epithelium, Degeneration    |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  47        |
      Mesenteric, Hematopoietic Cell       |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  56                                                               
NTP Experiment-Test: 05074-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  PENTACHLOROPHENOL, DOWICIDE EC7                              Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 14:47:10  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 7| 2| 7| 7| 6| 4| 7| 7| 6| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 9| 2| 1| 5| 2| 2| 1| 5| 2| 2| 8| 3| 2| 3| 2| 3| 7| 2| 2| 3| 2| 2| 3| 1|            |
                                           | 6| 5| 9| 1| 3| 9| 8| 1| 8| 9| 7| 0| 0| 8| 0| 8| 0| 9| 7| 8| 0| 7| 9| 0| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      T     |
                               ANIMAL ID   | 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1|      A     |
    600 PPM                                | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
          Proliferation                    |                3  3                             3           3  3  3     3|     10  2.8|
      Mesenteric, Hyperplasia, Lymphoid    |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  47        |
      Hyperplasia, Lymphoid                |                                  3                                       |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Depletion Lymphoid                   |    2                             3                                       |      2  2.5|
      Red Pulp, Hematopoietic Cell         |                                                                          |            |
          Proliferation, Diffuse           |                               4  3                 4     4              4|      7  3.9|
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  M  +  +  +  +  +  +  +  M  M  M  +  +  +  M  M  M  M  +  +  +  +  +  M|  27        |
      Necrosis, Acute                      |             3                                                            |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Acanthosis                           |       3  3        3              3                    3        3         |     10  2.8|
      Alopecia                             |       X                                               X        X         |     12     |
      Ulcer                                |             3                    3                    2        2         |      5  2.8|
      Subcutaneous Tissue, Fibrosis        |                                                                          |      1  2.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Acute                           |                                        4                                 |      2  3.5|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Chronic Active                  |       2                                                                  |      2  2.5|
      Subcutaneous Tissue, Mineralization  |       2                                                                  |      1  2.0|
      Subcutaneous Tissue, Lymphatic,      |                                                                          |            |
          Dilatation                       |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Joint, Tarsal, Hyperostosis          |    X                                   X     X        X                  |     12     |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Alveolar Epithelium, Hyperplasia     |                               2                                         2|      2  2.0|
      Alveolar Epithelium, Bronchiole,     |                                                                          |            |
           Hyperplasia                     |                                                                          |      1  2.0|
      Peribronchiolar, Glands,             |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  57                                                               
NTP Experiment-Test: 05074-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                  PENTACHLOROPHENOL, DOWICIDE EC7                              Date: 05/05/97  
Route: DOSED FEED                                                                                                 Time: 14:47:10  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 7| 2| 7| 7| 6| 4| 7| 7| 6| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 9| 2| 1| 5| 2| 2| 1| 5| 2| 2| 8| 3| 2| 3| 2| 3| 7| 2| 2| 3| 2| 2| 3| 1|            |
                                           | 6| 5| 9| 1| 3| 9| 8| 1| 8| 9| 7| 0| 0| 8| 0| 8| 0| 9| 7| 8| 0| 7| 9| 0| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      T     |
                               ANIMAL ID   | 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1|      A     |
    600 PPM                                | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
          Inflammation, Acute              |                                     3                                    |      1  3.0|
      Perivascular, Infiltration Cellular, |                                                                          |            |
           Lymphocyte                      |                                           2                              |      2  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Glands, Inflammation, Acute, Focal   | 2  2  2  2  2  2  2  2  2  2     2  2  2  2  2  2  2  2  1  2  2  2  2  2|     47  1.9|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Acute, Focal                    |    2                                   2                                 |      2  2.0|
      Olfactory Epithelium, Metaplasia,    |                                                                          |            |
           Focal                           | 2  2  2  2  2  2  2  2  2  2     2  2  2  2  2  2  2  2  2  2  2  2  2  2|     46  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
      Lens, Cataract                       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  M  M  M  +  +  +  M  M  +  +  +  M  +  M  M  +  +  +  +  +  +  M|  35        |
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cyst                                 |                                                                          |      4     |
      Nephropathy, Chronic                 |                                                                          |      1  2.0|
      Renal Tubule, Dilatation             |             2                                                            |      1  2.0|
      Renal Tubule, Regeneration           |                2  2        2           2              2        2     2   |     17  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Dilatation                           |             3                                                            |      3  3.7|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  58                                                               
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