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TR 349 Mouse Pathology Tables

NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11 
LAB: Battelle Columbus                                         DATE: 09/09/94   
EXP: 05074             DOWICIDE EC-7 PENTACHLOROPHENOL         TIME: 06:58:06   
TEST: 01              CAGES FROM 0000 TO LAST CAGE             PAGE:   1        
TEST TYPE: CHRONIC          ROUTE: DOSED FEED                  NTP C#: 55389    
CONT: N01-ES-38068                                             CAS: 87-86-5     
PATHOLOGIST: R. PERSING                      S. EUSTIS                          
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REASONS FOR REMOVAL:                                                            
                                                                                
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REMOVAL DATE RANGE:                                                             


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INCLUDE ALL                                                                     

NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11
LAB: Battelle Columbus                                         DATE: 09/09/94  
EXP: 05074             DOWICIDE EC-7 PENTACHLOROPHENOL         TIME: 06:58:06  
TEST: 01              CAGES FROM 0000 TO LAST CAGE                             
TEST TYPE: CHRONIC          ROUTE: DOSED FEED                  NTP C#: 55389   
CONT: N01-ES-38068                                             CAS: 87-86-5    
PATHOLOGIST: R. PERSING                      S. EUSTIS                         

                          DOWICIDE EC-7 PENTACHLOROPHENOL


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 727 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 0 PPM                                    |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 35     UNCENSORED DEATHS 10     CENSORED DEATHS 0    TERMINAL 25        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      199   224   454   468   471   498   528   681   705   710                 |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 100 PPM                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 22     CENSORED DEATHS 0    TERMINAL 28        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      63    254   305   431   440   477   489   513   532   568                 |
 |      611   612   612   613   655   659   659   690   695   697                 |
 |      705   723                                                                 |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 200 PPM                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 21     CENSORED DEATHS 0    TERMINAL 29        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      26    134   140   292   292   293   293   315   324   342                 |
 |      352   416   541   551   578   598   603   608   660   681                 |
 |      690                                                                       |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================

                          DOWICIDE EC-7 PENTACHLOROPHENOL


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 727 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 600 PPM                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 15     CENSORED DEATHS 0    TERMINAL 35        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      57    253   365   379   458   536   604   608   608   611                 |
 |      635   680   695   711   717                                               |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================

                          DOWICIDE EC-7 PENTACHLOROPHENOL


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 727 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   727 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |0 PPM      |   100.0 100.0  94.3  94.3  94.3  85.7  80.0  80.0  80.0  71.4      |
 |           |                                                                    |
 |           |                                                                    |
 |100 PPM    |    98.0  98.0  96.0  94.0  94.0  88.0  82.0  80.0  66.0  56.0      |
 |           |                                                                    |
 |           |                                                                    |
 |200 PPM    |    98.0  94.0  94.0  78.0  76.0  76.0  74.0  66.0  62.0  58.0      |
 |           |                                                                    |
 |           |                                                                    |
 |600 PPM    |    98.0  98.0  96.0  94.0  92.0  90.0  88.0  86.0  78.0  70.0      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                  DOSE                          |
 |                                                                                |
 |                                0 PPM        100 PPM      200 PPM      600 PPM  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       71.4%        56.0%        58.0%        70.0%    |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.496N     P=0.255      P=0.241      P=1.000  |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       493.8        545.6        415.7        527.8    |
 |NATURAL DEATHS (C)      |       (56.8)       (35.7)       (42.7)       (49.2)   |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       660.4        647.2        596.2        667.2    |
 |(STANDARD ERROR)        |       (23.9)       (20.1)       (28.2)       (19.4)   |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                          DOWICIDE EC-7 PENTACHLOROPHENOL


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 727 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 0 PPM                                    |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 35     UNCENSORED DEATHS 6      CENSORED DEATHS 0    TERMINAL 29        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      494   643   685   717   720   722                                         |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 100 PPM                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 21     CENSORED DEATHS 1    TERMINAL 28        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      321   443   454   483   497   521   542   566   572   596                 |
 |      629   631   636   643   645   669   701   712   713   714                 |
 |      720                                                                       |
 |  CENSORED DEATHS                                                               |
 |      564                                                                       |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 200 PPM                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 12     CENSORED DEATHS 0    TERMINAL 38        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      514   626   631   635   636   648   689   699   706   707                 |
 |      710   711                                                                 |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================

                          DOWICIDE EC-7 PENTACHLOROPHENOL


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 727 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 600 PPM                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 11     CENSORED DEATHS 0    TERMINAL 39        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      485   502   516   528   555   611   653   668   670   689                 |
 |      712                                                                       |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================

                          DOWICIDE EC-7 PENTACHLOROPHENOL


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 727 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   727 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |0 PPM      |   100.0 100.0 100.0 100.0 100.0 100.0  97.1  97.1  94.3  82.9      |
 |           |                                                                    |
 |           |                                                                    |
 |100 PPM    |   100.0 100.0 100.0  98.0  98.0  92.0  86.0  79.9  69.6  57.3      |
 |           |                                                                    |
 |           |                                                                    |
 |200 PPM    |   100.0 100.0 100.0 100.0 100.0 100.0  98.0  98.0  88.0  76.0      |
 |           |                                                                    |
 |           |                                                                    |
 |600 PPM    |   100.0 100.0 100.0 100.0 100.0  98.0  92.0  90.0  86.0  78.0      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                  DOSE                          |
 |                                                                                |
 |                                0 PPM        100 PPM      200 PPM      600 PPM  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       82.9%        57.3%        76.0%        78.0%    |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.567N     P=0.016      P=0.558      P=0.687  |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       663.5        590.9        659.3        599.0    |
 |NATURAL DEATHS (C)      |       (36.1)       (23.5)       (16.6)       (25.2)   |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       716.1        666.6        710.8        698.8    |
 |(STANDARD ERROR)        |       ( 7.0)       (13.8)       ( 5.6)       ( 9.3)   |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                                  DOWICIDE EC-7 PENTACHLOROPHENOL
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        0 PPM            = 1
                                                        100 PPM          = 2
                                                        200 PPM          = 3
                                                        600 PPM          = 4

------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  104 +
      |
      | 1   3     2                     1
      |     3     2           3         1  1     2
P  96 +                                          2      2         4
E     |                       3            1          3 2         4  4      2   1
R     |                                                              4      22  141
C     |                                                                      2   4  2        4
E  88 +                                                                           1122       4          4
N     |                                               3   3                        1 2 1 2
T     |                                                   3 3                            2  2
      |                                                     3 3                        1    1     2     44
S  80 +                                                       3 3                           1     2      2  4       1
U     |                                                         3         3                                 4       1  1
R     |                                                                   3                   3                     4 4
V     |                                                                                       33                      411
I  72 +                                                                                        3   3     2     2        141
V     |                                                                                            3   3       2 2       44
A     |                                                                                                33
L     |                                                                                                          2   2
   64 +                                                                                                 3        3   22
      |                                                                                                          3  3
      |                                                                                                             3322
      |                                                                                                              3 2  2
   56 +                                                                                                                   2
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 13 obs hidden.

                                                  DOWICIDE EC-7 PENTACHLOROPHENOL
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        0 PPM            = 1
                                                        100 PPM          = 2
                                                        200 PPM          = 3
                                                        600 PPM          = 4

----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1                                                  2                         41  3
      |
      |                                                    2                  2      414 3                 3 1
      |                                                                       2 2      4 4                 33
   95 +
      |                                                                         2   2    4  4                1      1
      |                                                                             2 2     4   4
      |                                                                                                             1    1
   90 +                                                                               2    2    4        4  3 3
      |
P     |                                                                                    2  2          4    34     3
E     |                                                                                       2  2             4  4  33  11
R  85 +
C     |                                                                                          22                   33
E     |                                                                                           2    2          4  4    1
N     |
T  80 +                                                                                                2   2         4 33
      |
S     |                                                                                                    22           4 4
U     |                                                                                                                 3 3
R  75 +
V     |                                                                                                     22
I     |
V     |                                                                                                      22
A  70 +                                                                                                       2   2
L     |
      |                                                                                                           2    2
      |
   65 +                                                                                                                22
      |
      |
      |
   60 +                                                                                                                 22
      |
      |                                                                                                                  22
      |
   55 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 4 obs hidden.

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