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TR 351 Mouse Pathology Tables


                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                         PARA-CHLOROANILINE


NTP Experiment-Test: 05020-02                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 09/03/94
Route: GAVAGE                                                                                                     Time: 19:58:17




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  106-47-8

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05020-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 19:58:17  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      3 MG/KG      10 MG/KG     30 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund                                           5            4            3            4                                     
    Dead                                               5            1            3            5                                     
    Dosing Accident                                    1            3                                                               
  Survivors                                                                                                                         
    Terminal Sacrifice                                39           42           44           41                                     
  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (47)         (3)          (2)          (46)                                   
      Infiltration Cellular, Multifocal, Lymphocyte                                           1 (2%)                                
      Lumen, Pigmentation, Diffuse                                                            1 (2%)                                
      Mucosa, Cyst                                                                            1 (2%)                                
   Intestine Large, Colon                             (47)         (5)          (3)          (48)                                   
      Parasite Metazoan                                3 (6%)                                                                       
   Intestine Small, Duodenum                          (46)         (4)          (3)          (48)                                   
      Inflammation, Chronic, Focal                     1 (2%)                                                                       
      Ulcer, Chronic, Focal                            1 (2%)                                                                       
   Intestine Small, Jejunum                           (46)         (4)          (2)          (48)                                   
      Necrosis, Acute, Diffuse                                                                1 (2%)                                
   Liver                                              (50)         (50)         (50)         (50)                                   
      Angiectasis, Focal                               1 (2%)                                                                       
      Basophilic Focus                                 1 (2%)                                 1 (2%)                                
      Clear Cell Focus                                 1 (2%)       2 (4%)                                                          
      Cytomegaly, Focal                                                          1 (2%)       1 (2%)                                
      Hematopoietic Cell Proliferation, Multifocal    15 (30%)     29 (58%)     24 (48%)     31 (62%)                               
      Necrosis, Acute, Multifocal                      1 (2%)       1 (2%)       1 (2%)       1 (2%)                                
      Thrombosis, Chronic                                                                     1 (2%)                                
      Vacuolization Cytoplasmic, Focal                                           1 (2%)       1 (2%)                                
      Bile Duct, Cyst                                               1 (2%)                                                          
      Centrilobular, Necrosis, Acute, Multifocal                                              1 (2%)                                
      Hepatocyte, Karyomegaly, Focal                   1 (2%)       1 (2%)                                                          
      Kupffer Cell, Pigmentation, Hemosiderin                                    1 (2%)      46 (92%)                               
      Periportal, Inflammation, Multifocal             1 (2%)                                                                       
      Serosa, Inflammation, Chronic, Multifocal,                                                                                    
           Suppurative                                                                        1 (2%)                                
      Sinusoid, Infiltration Cellular, Diffuse,                                                                                     
           Polymorphonuclear                           1 (2%)                                                                       
   Mesentery                                          (2)          (2)          (3)          (3)                                    
      Inflammation, Chronic, Multifocal,                                                                                            
          Suppurative                                                                         2 (67%)                               
      Inflammation, Chronic Active, Multifocal                      2 (100%)     2 (67%)      1 (33%)                               
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05020-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 19:58:17  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      3 MG/KG      10 MG/KG     30 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
   Pancreas                                           (48)         (7)          (5)          (49)                                   
      Inflammation, Chronic, Multifocal,                                                                                            
          Suppurative                                                                         1 (2%)                                
      Inflammation, Chronic Active, Multifocal                      1 (14%)      1 (20%)                                            
      Acinus, Atrophy, Diffuse                         1 (2%)                                                                       
      Acinus, Atrophy, Focal                           1 (2%)                                 2 (4%)                                
      Acinus, Atrophy, Multifocal                      1 (2%)       1 (14%)      2 (40%)      5 (10%)                               
      Duct, Cyst                                                    1 (14%)                   1 (2%)                                
      Duct, Cyst, Multiple                             1 (2%)                                                                       
      Duct, Ectasia, Focal                                                                    1 (2%)                                
      Duct, Ectasia, Multifocal                                                  1 (20%)                                            
      Duct, Inflammation, Chronic, Multifocal          1 (2%)                                                                       
   Salivary Glands                                    (47)         (5)          (3)          (48)                                   
      Infiltration Cellular, Multifocal, Lymphocyte                                           3 (6%)                                
      Acinus, Atrophy, Focal                                                                  1 (2%)                                
   Stomach, Forestomach                               (48)         (5)          (3)          (46)                                   
      Acanthosis, Focal                                                                       1 (2%)                                
      Hyperkeratosis, Focal                                                                   1 (2%)                                
      Ulcer, Acute, Focal                                                                     1 (2%)                                
   Stomach, Glandular                                 (48)         (5)          (3)          (47)                                   
      Cyst                                                                                    1 (2%)                                
      Necrosis, Acute, Focal                           1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (5)          (3)          (50)                                   
      Atrium, Inflammation, Chronic, Focal                                       1 (33%)                                            
      Coronary Artery, Inflammation, Chronic                                                                                        
          Active, Multifocal                                                                  1 (2%)                                
      Epicardium, Inflammation, Acute, Multifocal                   1 (20%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (50)         (5)          (4)          (49)                                   
      Capsule, Cyst                                    1 (2%)                                                                       
      Capsule, Hyperplasia, Cystic, Glandular,                                                                                      
           Multifocal                                  1 (2%)                                                                       
      Capsule, Hyperplasia, Focal                                                             1 (2%)                                
      Capsule, Hyperplasia, Multifocal                48 (96%)      2 (40%)      3 (75%)     48 (98%)                               
      Corticomedullary Junction, Degeneration,                                                                                      
           Fatty, Multifocal                                                                  1 (2%)                                
   Adrenal Gland, Cortex                              (50)         (5)          (4)          (49)                                   
      Accessory Adrenal Cortical Nodule                1 (2%)                                                                       
      Degeneration, Fatty, Focal                                                              1 (2%)                                
      Hematopoietic Cell Proliferation, Multifocal                                            1 (2%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05020-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 19:58:17  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      3 MG/KG      10 MG/KG     30 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Hyperplasia, Focal                               1 (2%)                                 1 (2%)                                
      Hyperplasia, Multifocal                          1 (2%)                                                                       
      Hypertrophy, Focal                               2 (4%)                                 2 (4%)                                
      Hypertrophy, Multifocal                          1 (2%)                                 1 (2%)                                
   Adrenal Gland, Medulla                             (50)         (5)          (4)          (49)                                   
      Hyperplasia, Focal                               1 (2%)                                                                       
      Infiltration Cellular, Focal, Plasma Cell                                               1 (2%)                                
   Pituitary Gland                                    (46)         (5)          (6)          (42)                                   
      Pars Distalis, Cyst                              3 (7%)                                 1 (2%)                                
      Pars Distalis, Cyst, Multiple                    1 (2%)                                                                       
      Pars Distalis, Hyperplasia, Focal                5 (11%)                   1 (17%)      6 (14%)                               
      Pars Distalis, Hyperplasia, Multifocal           2 (4%)                                                                       
   Thyroid Gland                                      (49)         (4)          (3)          (49)                                   
      Necrosis, Acute, Focal                           1 (2%)                                                                       
      Follicular Cell, Hyperplasia                                                            1 (2%)                                
      Follicular Cell, Hyperplasia, Focal              1 (2%)                                 1 (2%)                                
      Follicular Cell, Hyperplasia, Multifocal                                                1 (2%)                                
      Interstitium, Inflammation, Chronic, Focal                                              1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (50)         (14)         (17)         (47)                                   
      Angiectasis, Focal                                                                      1 (2%)                                
      Angiectasis, Multifocal                          1 (2%)                    1 (6%)                                             
      Inflammation, Chronic, Multifocal,                                                                                            
          Suppurative                                                                         2 (4%)                                
      Thrombosis, Chronic Active                       1 (2%)       1 (7%)                                                          
      Corpus Luteum, Angiectasis, Multifocal                                                  1 (2%)                                
      Follicle, Cyst                                  10 (20%)      7 (50%)     11 (65%)     14 (30%)                               
      Follicle, Cyst, Multiple                         3 (6%)                                 1 (2%)                                
      Periovarian Tissue, Cyst                         3 (6%)       1 (7%)       5 (29%)      1 (2%)                                
      Periovarian Tissue, Infiltration Cellular,                                                                                    
           Multifocal, Lymphocyte                                                             1 (2%)                                
      Periovarian Tissue, Inflammation, Chronic                                                                                     
          Active, Multifocal                                        1 (7%)                                                          
      Rete Ovarii, Cyst                                                                       1 (2%)                                
   Uterus                                             (50)         (38)         (42)         (48)                                   
      Inflammation, Chronic, Multifocal,                                                                                            
          Suppurative                                               1 (3%)                    2 (4%)                                
      Endometrium, Angiectasis, Multifocal             1 (2%)                                                                       
      Endometrium, Hyperplasia, Cystic, Glandular,                                                                                  
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05020-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 19:58:17  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      3 MG/KG      10 MG/KG     30 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
           Multifocal                                 45 (90%)     35 (92%)     41 (98%)     43 (90%)                               
      Mucosa, Metaplasia, Multifocal, Squamous                                                1 (2%)                                
      Myometrium, Angiectasis, Multifocal              1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Blood                                              (1)                       (2)          (3)                                    
      Neutrophilia                                                                            3 (100%)                              
   Bone Marrow                                        (48)         (5)          (3)          (49)                                   
      Femoral, Angiectasis, Focal                      1 (2%)                                                                       
      Femoral, Hyperplasia, Diffuse, Neutrophil                                               2 (4%)                                
      Femoral, Myelofibrosis, Multifocal               3 (6%)                                 4 (8%)                                
   Lymph Node                                         (48)         (5)          (7)          (47)                                   
      Mediastinal, Hyperplasia, Diffuse, Lymphoid                                             2 (4%)                                
      Pancreatic, Inflammation, Chronic Active,                                                                                     
           Multifocal                                                            1 (14%)                                            
      Renal, Hyperplasia, Diffuse, Lymphoid                                                   1 (2%)                                
   Lymph Node, Mandibular                             (46)         (5)          (5)          (47)                                   
      Hyperplasia, Diffuse, Lymphoid                                                          1 (2%)                                
      Hyperplasia, Multifocal, Plasma Cell                                                    1 (2%)                                
      Lymphatic, Angiectasis, Diffuse                                            1 (20%)                                            
   Lymph Node, Mesenteric                             (8)                       (4)          (3)                                    
      Cyst                                                                       1 (25%)                                            
      Hematopoietic Cell Proliferation, Multifocal                               1 (25%)                                            
      Lymphatic, Ectasia, Focal                        1 (13%)                                                                      
   Spleen                                             (50)         (50)         (50)         (49)                                   
      Capsule, Hyperplasia, Multifocal                                                        1 (2%)                                
      Capsule, Inflammation, Chronic Active,                                                                                        
          Multifocal                                                             1 (2%)                                             
      Lymphoid Follicle, Necrosis, Acute,                                                                                           
          Multifocal                                   1 (2%)       2 (4%)                                                          
      Red Pulp, Hematopoietic Cell Proliferation,                                                                                   
           Diffuse                                    48 (96%)     50 (100%)    49 (98%)     48 (98%)                               
      Red Pulp, Pigmentation, Hemosiderin,                                                                                          
          Multifocal                                  45 (90%)     47 (94%)     49 (98%)     49 (100%)                              
   Thymus                                             (41)         (4)          (1)          (35)                                   
      Depletion Lymphoid, Multifocal                                                          1 (3%)                                
      Necrosis, Acute, Multifocal                      1 (2%)       3 (75%)                                                         
      Medulla, Thymocyte, Hyperplasia, Diffuse         1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05020-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 19:58:17  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      3 MG/KG      10 MG/KG     30 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (38)         (5)          (3)          (44)                                   
      Hyperplasia, Cystic, Multifocal                                            2 (67%)                                            
   Skin                                               (50)         (7)          (7)          (49)                                   
      Parasite External                                3 (6%)                                                                       
      Ulcer                                                                      2 (29%)                                            
      Subcutaneous Tissue, Fibrosis, Multifocal                                  1 (14%)                                            
      Subcutaneous Tissue, Inflammation, Chronic                                                                                    
          Active, Multifocal                                                     2 (29%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (49)         (6)          (3)          (50)                                   
      Bilateral, Joint, Tarsal, Hyperostosis           1 (2%)                                                                       
      Bilateral, Joint, Tarsal, Metaplasia,                                                                                         
          Multifocal, Osseous                          1 (2%)                                                                       
      Cranium, Fibrous Osteodystrophy                                                         1 (2%)                                
      Cranium, Hyperostosis, Focal                                                            1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (48)         (5)          (3)          (49)                                   
      Hemorrhage, Multifocal                           1 (2%)                                                                       
      Necrosis, Acute, Multifocal                                                1 (33%)                                            
      Hypothalamus, Compression, Focal                                                        1 (2%)                                
      Meninges, Infiltration Cellular, Multifocal,                                                                                  
           Lymphocyte                                  1 (2%)                                 2 (4%)                                
      Meninges, Inflammation, Chronic Active,                                                                                       
          Multifocal                                                                          1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (8)          (7)          (50)                                   
      Alveolar Epithelium, Hyperplasia, Focal                       1 (13%)                   3 (6%)                                
      Alveolus, Hemorrhage, Multifocal                                           1 (14%)      1 (2%)                                
      Interstitium, Inflammation, Chronic,                                                                                          
          Multifocal                                   2 (4%)                                                                       
      Interstitium, Inflammation, Chronic Active,                                                                                   
           Focal                                                                              1 (2%)                                
      Interstitium, Inflammation, Chronic Active,                                                                                   
           Multifocal                                  1 (2%)                                                                       
      Mediastinum, Foreign Body, Multifocal            1 (2%)       3 (38%)                                                         
      Perivascular, Hyperplasia, Lymphoid,                                                                                          
          Multifocal                                   1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05020-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 19:58:17  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      3 MG/KG      10 MG/KG     30 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Perivascular, Inflammation, Chronic,                                                                                          
          Multifocal                                                                          1 (2%)                                
      Pleura, Inflammation, Acute, Diffuse                          1 (13%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (1)          (1)                       (1)                                    
      Degeneration, Diffuse                                                                   1 (100%)                              
      Cornea, Inflammation, Chronic Active,                                                                                         
          Diffuse, Necrotizing                                      1 (100%)                                                        
   Harderian Gland                                    (48)         (4)          (3)          (47)                                   
      Inflammation, Chronic Active, Diffuse            1 (2%)                                                                       
      Acinus, Hyperplasia, Multifocal                                                         1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (7)          (4)          (49)                                   
      Inflammation, Chronic Active, Multifocal                                   1 (25%)                                            
      Mineralization, Multifocal                                                              1 (2%)                                
      Nephropathy, Chronic, Diffuse                    1 (2%)                                                                       
      Nephropathy, Chronic, Focal                      3 (6%)                                 1 (2%)                                
      Nephropathy, Chronic, Multifocal                 1 (2%)                                 1 (2%)                                
      Capsule, Fibrosis, Chronic, Focal                                          1 (25%)                                            
      Glomerulus, Amyloid Deposition, Multifocal       1 (2%)                                                                       
      Glomerulus, Inflammation, Chronic, Multifocal                                           3 (6%)                                
      Perivascular, Infiltration Cellular,                                                                                          
          Multifocal, Plasma Cell                                                             1 (2%)                                
      Renal Tubule, Cytoplasmic Alteration, Diffuse                 1 (14%)                                                         
      Renal Tubule, Dilatation, Diffuse                                                       1 (2%)                                
      Renal Tubule, Pigmentation, Hemosiderin,                                                                                      
           Multifocal                                                                        38 (78%)                               
      Renal Tubule, Regeneration, Focal                3 (6%)                                                                       
      Renal Tubule, Regeneration, Multifocal           4 (8%)                                 3 (6%)                                
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05020-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 19:58:17  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      3 MG/KG      10 MG/KG     30 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund                                           3            6           12            9                                     
    Dead                                               4            7            9            6                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                43           36           29           35                                     
  Missing                                                           1                                                               
  Animals Examined Microscopically                    50           49           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (45)                      (4)          (47)                                   
      Necrosis, Acute, Multifocal                                                1 (25%)                                            
      Lumen, Crystals, Diffuse                                                                1 (2%)                                
      Submucosa, Fibrosis, Diffuse                                               1 (25%)                                            
   Intestine Large, Colon                             (48)         (6)          (7)          (48)                                   
      Inflammation, Acute, Multifocal, Necrotizing                  1 (17%)                                                         
      Parasite Metazoan                                             1 (17%)                   3 (6%)                                
   Intestine Large, Rectum                            (46)         (1)          (5)          (50)                                   
      Parasite Metazoan                                                                       2 (4%)                                
   Liver                                              (50)         (49)         (50)         (50)                                   
      Amyloid Deposition, Multifocal                                             1 (2%)                                             
      Angiectasis, Focal                               1 (2%)                                 2 (4%)                                
      Angiectasis, Multifocal                                                                 3 (6%)                                
      Clear Cell Focus, Focal                          1 (2%)                                                                       
      Cyst                                                          1 (2%)       1 (2%)                                             
      Hematopoietic Cell Proliferation, Diffuse        1 (2%)                                 2 (4%)                                
      Hematopoietic Cell Proliferation, Focal                                    1 (2%)                                             
      Hematopoietic Cell Proliferation, Multifocal     6 (12%)      4 (8%)       6 (12%)      3 (6%)                                
      Inflammation                                                  1 (2%)                                                          
      Inflammation, Acute, Multifocal                                                         1 (2%)                                
      Inflammation, Chronic, Multifocal                                          2 (4%)                                             
      Inflammation, Chronic Active, Multifocal                                                1 (2%)                                
      Necrosis, Acute, Multifocal                                                             1 (2%)                                
      Necrosis, Chronic Active, Focal                  1 (2%)                                                                       
      Necrosis, Chronic Active, Multifocal                          1 (2%)       1 (2%)       6 (12%)                               
      Necrosis, Coagulative, Focal                                               1 (2%)                                             
      Thrombosis, Chronic                                                                     2 (4%)                                
      Vacuolization Cytoplasmic, Focal                              1 (2%)                                                          
      Bile Duct, Hyperplasia, Multifocal                                         2 (4%)                                             
      Centrilobular, Necrosis, Acute, Multifocal       1 (2%)                                                                       
      Centrilobular, Vacuolization Cytoplasmic,                                                                                     
           Diffuse                                     4 (8%)                                 4 (8%)                                
      Hepatocyte, Cytomegaly, Diffuse                                            1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05020-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 19:58:17  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      3 MG/KG      10 MG/KG     30 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Hepatocyte, Hyperplasia, Focal                                             1 (2%)                                             
      Kupffer Cell, Pigmentation, Hemosiderin                                                50 (100%)                              
   Pancreas                                           (49)         (3)          (7)          (49)                                   
      Inflammation, Chronic, Multifocal                                                       1 (2%)                                
      Acinus, Atrophy, Focal                                                                  1 (2%)                                
      Acinus, Atrophy, Multifocal                      6 (12%)                                4 (8%)                                
   Tooth                                              (50)         (5)          (7)          (50)                                   
      Incisor, Dysplasia, Multifocal                                                          1 (2%)                                
      Molar, Dysplasia                                 1 (2%)                                 1 (2%)                                
      Peridontal Tissue, Foreign Body, Focal           2 (4%)                                                                       
      Peridontal Tissue, Foreign Body, Multifocal      1 (2%)                                                                       
      Peridontal Tissue, Inflammation, Chronic                                                                                      
          Active, Focal                                3 (6%)                                 4 (8%)                                
      Peridontal Tissue, Inflammation, Chronic                                                                                      
          Active, Multifocal                           6 (12%)                                3 (6%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (5)          (8)          (50)                                   
      Coronary Artery, Inflammation, Chronic                                                                                        
          Active, Focal                                                                       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (49)         (5)          (7)          (50)                                   
      Capsule, Ectopic Tissue                          2 (4%)                                                                       
      Capsule, Hyperplasia, Focal                      2 (4%)       1 (20%)                   1 (2%)                                
      Capsule, Hyperplasia, Multifocal                44 (90%)      1 (20%)      4 (57%)     44 (88%)                               
   Adrenal Gland, Cortex                              (49)         (5)          (7)          (50)                                   
      Cyst                                                                                    2 (4%)                                
      Hyperplasia, Focal                              11 (22%)                                5 (10%)                               
      Hyperplasia, Multifocal                                                                 1 (2%)                                
      Hypertrophy, Focal                               9 (18%)                               10 (20%)                               
      Hypertrophy, Multifocal                          5 (10%)                                                                      
      Necrosis, Acute, Focal                                                                  1 (2%)                                
      Vacuolization Cytoplasmic, Focal                                                        1 (2%)                                
   Adrenal Gland, Medulla                             (49)         (4)          (7)          (50)                                   
      Hyperplasia, Focal                               1 (2%)                                                                       
   Parathyroid Gland                                  (36)         (4)          (1)          (38)                                   
      Cyst                                                                                    1 (3%)                                
   Pituitary Gland                                    (40)         (4)          (4)          (41)                                   
      Pars Distalis, Cyst                              1 (3%)                                 2 (5%)                                
      Pars Distalis, Cyst, Multiple                                                           1 (2%)                                
      Pars Distalis, Hyperplasia, Focal                                                       1 (2%)                                
   Thyroid Gland                                      (50)         (5)          (7)          (48)                                   
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05020-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 19:58:17  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      3 MG/KG      10 MG/KG     30 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Inflammation, Chronic Active, Multifocal         1 (2%)                                                                       
      Follicle, Cyst, Multiple                         1 (2%)                                                                       
      Follicular Cell, Hyperplasia, Focal              1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (49)         (5)          (7)          (49)                                   
      Infiltration Cellular, Multifocal, Lymphocyte                                           2 (4%)                                
      Inflammation, Chronic, Multifocal                                                       1 (2%)                                
      Inflammation, Chronic Active, Multifocal                                                4 (8%)                                
   Penis                                                           (1)          (2)                                                 
      Concretion, Chronic Active, Multifocal                        1 (100%)                                                        
      Inflammation, Chronic Active, Multifocal                      1 (100%)                                                        
   Preputial Gland                                    (2)          (3)          (5)          (5)                                    
      Atrophy, Diffuse                                 2 (100%)                                                                     
      Atrophy, Multifocal                                                        1 (20%)      1 (20%)                               
      Inflammation, Chronic Active, Diffuse            1 (50%)                                                                      
      Inflammation, Chronic Active, Multifocal                      2 (67%)      1 (20%)      1 (20%)                               
      Inflammation, Multifocal, Suppurative                                      2 (40%)                                            
      Duct, Dilatation, Focal                                       1 (33%)      1 (20%)                                            
      Duct, Dilatation, Multifocal                     1 (50%)                   2 (40%)                                            
   Prostate                                           (48)         (4)          (7)          (50)                                   
      Inflammation, Acute, Diffuse                                                            1 (2%)                                
      Inflammation, Chronic Active, Multifocal                      1 (25%)                   1 (2%)                                
      Epithelium, Hyperplasia, Focal                                                          1 (2%)                                
   Testes                                             (49)         (5)          (7)          (50)                                   
      Germinal Epithelium, Degeneration, Chronic,                                                                                   
           Multifocal                                                                         1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Blood                                              (2)                       (2)                                                 
      Neutrophilia                                     2 (100%)                  1 (50%)                                            
   Bone Marrow                                        (50)         (3)          (7)          (50)                                   
      Hyperplasia, Diffuse, Neutrophil                 3 (6%)                    1 (14%)      5 (10%)                               
      Hyperplasia, Multifocal, Neutrophil              1 (2%)                                                                       
      Thrombosis, Chronic Active                       1 (2%)                                                                       
      Femoral, Angiectasis, Focal                                                             2 (4%)                                
   Lymph Node                                         (49)         (25)         (28)         (49)                                   
      Mediastinal, Hematopoietic Cell                                                                                               
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05020-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 19:58:17  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      3 MG/KG      10 MG/KG     30 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
          Proliferation, Diffuse                       1 (2%)                                                                       
      Mediastinal, Hematopoietic Cell                                                                                               
          Proliferation, Multifocal                    2 (4%)                                 1 (2%)                                
      Pancreatic, Hematopoietic Cell Proliferation,                                                                                 
           Multifocal                                  1 (2%)                                                                       
      Renal, Hyperplasia, Multifocal, Plasma Cell      1 (2%)                                                                       
   Lymph Node, Mandibular                             (48)         (8)          (9)          (49)                                   
      Depletion Lymphoid, Diffuse                                   1 (13%)                                                         
      Hematopoietic Cell Proliferation, Multifocal     1 (2%)                                                                       
      Hyperplasia, Lymphoid, Multifocal                2 (4%)       3 (38%)      1 (11%)                                            
      Hyperplasia, Multifocal, Plasma Cell             2 (4%)                    1 (11%)      3 (6%)                                
      Lymphocyte, Necrosis, Multifocal                                                        1 (2%)                                
   Lymph Node, Mesenteric                             (22)         (19)         (20)         (17)                                   
      Angiectasis, Multifocal                                                    1 (5%)                                             
      Hematocyst, Chronic Active                                                              1 (6%)                                
      Hematopoietic Cell Proliferation, Multifocal    10 (45%)     18 (95%)     18 (90%)     14 (82%)                               
      Hemorrhage, Multifocal                           4 (18%)                                                                      
      Hyperplasia, Diffuse, Lymphoid                   1 (5%)                                                                       
      Hyperplasia, Lymphoid, Multifocal                                                       1 (6%)                                
      Inflammation, Chronic, Multifocal                                                       1 (6%)                                
      Inflammation, Focal, Granulomatous                                         1 (5%)                                             
      Inflammation, Multifocal, Suppurative                         1 (5%)                                                          
   Spleen                                             (50)         (47)         (49)         (49)                                   
      Amyloid Deposition, Multifocal                                             1 (2%)                                             
      Angiectasis, Focal                                                         1 (2%)       2 (4%)                                
      Angiectasis, Multifocal                                                    1 (2%)                                             
      Lymphoid Follicle, Depletion Lymphoid,                                                                                        
          Multifocal                                                1 (2%)                                                          
      Lymphoid Follicle, Necrosis, Acute,                                                                                           
          Multifocal                                                1 (2%)                                                          
      Red Pulp, Angiectasis, Focal                                                            1 (2%)                                
      Red Pulp, Fibrosis                               1 (2%)                                                                       
      Red Pulp, Fibrosis, Multifocal                                1 (2%)                    1 (2%)                                
      Red Pulp, Hematopoietic Cell Proliferation,                                                                                   
           Diffuse                                    50 (100%)    47 (100%)    49 (100%)    48 (98%)                               
      Red Pulp, Pigmentation, Hemosiderin,                                                                                          
          Multifocal                                  37 (74%)     47 (100%)    45 (92%)     48 (98%)                               
   Thymus                                             (36)                      (3)          (27)                                   
      Cyst, Multiple                                                                          1 (4%)                                
      Depletion Lymphoid, Multifocal                                                          1 (4%)                                
      Necrosis, Acute, Multifocal                      1 (3%)                                 2 (7%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
NTP Experiment-Test: 05020-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 19:58:17  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      3 MG/KG      10 MG/KG     30 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (49)         (27)         (28)         (49)                                   
      Acanthosis, Diffuse                              1 (2%)       3 (11%)      5 (18%)      4 (8%)                                
      Acanthosis, Focal                                             2 (7%)                    1 (2%)                                
      Acanthosis, Multifocal                           9 (18%)      4 (15%)      2 (7%)       7 (14%)                               
      Alopecia                                                                                1 (2%)                                
      Hyperkeratosis, Multifocal                       1 (2%)                                 1 (2%)                                
      Inflammation, Chronic Active, Multifocal                      1 (4%)                                                          
      Parasite External                                7 (14%)                               12 (24%)                               
      Ulcer                                            6 (12%)      9 (33%)      8 (29%)      5 (10%)                               
      Ulcer, Multiple                                                                         4 (8%)                                
      Sebaceous Gland, Hyperplasia, Focal                           1 (4%)                                                          
      Subcutaneous Tissue, Fibrosis, Diffuse           1 (2%)       1 (4%)       4 (14%)      3 (6%)                                
      Subcutaneous Tissue, Fibrosis, Focal             1 (2%)       2 (7%)       1 (4%)       1 (2%)                                
      Subcutaneous Tissue, Fibrosis, Multifocal        5 (10%)      4 (15%)      1 (4%)       2 (4%)                                
      Subcutaneous Tissue, Inflammation, Acute,                                                                                     
           Multifocal                                               1 (4%)                                                          
      Subcutaneous Tissue, Inflammation, Chronic                                                                                    
          Active, Diffuse                                           1 (4%)       2 (7%)                                             
      Subcutaneous Tissue, Inflammation, Chronic                                                                                    
          Active, Focal                                             2 (7%)                    1 (2%)                                
      Subcutaneous Tissue, Inflammation, Chronic                                                                                    
          Active, Multifocal                           2 (4%)       5 (19%)      1 (4%)       7 (14%)                               
      Subcutaneous Tissue, Inflammation, Multifocal                              1 (4%)                                             
      Subcutaneous Tissue, Mineralization,                                                                                          
          Multifocal                                                             1 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (49)         (28)         (26)         (50)                                   
      Bilateral, Joint, Radius, Hyperostosis           1 (2%)                                                                       
      Bilateral, Joint, Tarsal, Hyperostosis          10 (20%)     21 (75%)     16 (62%)     11 (22%)                               
      Bilateral, Joint, Tarsal, Metaplasia,                                                                                         
          Multifocal, Osseous                         10 (20%)     21 (75%)     16 (62%)     11 (22%)                               
      Joint, Tarsal, Hyperostosis                     11 (22%)      2 (7%)       4 (15%)      9 (18%)                               
      Joint, Tarsal, Metaplasia, Multifocal,                                                                                        
          Osseous                                     11 (22%)      2 (7%)       4 (15%)      9 (18%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   12                                                              
NTP Experiment-Test: 05020-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 19:58:17  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      3 MG/KG      10 MG/KG     30 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (10)         (14)         (50)                                   
      Alveolar Epithelium, Hyperplasia, Focal          1 (2%)                    1 (7%)       4 (8%)                                
      Interstitium, Inflammation, Acute, Diffuse                                              1 (2%)                                
      Interstitium, Inflammation, Acute, Multifocal                                           1 (2%)                                
      Interstitium, Inflammation, Chronic Active,                                                                                   
           Focal                                       1 (2%)                                                                       
      Interstitium, Inflammation, Chronic Active,                                                                                   
           Multifocal                                  1 (2%)       1 (10%)                                                         
   Nose                                               (50)         (5)          (7)          (50)                                   
      Respiratory Epithelium, Inflammation, Acute,                                                                                  
           Multifocal                                                            1 (14%)      1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (2)                       (1)          (3)                                    
      Cataract                                         1 (50%)                                1 (33%)                               
      Inflammation, Chronic, Multifocal                                                       1 (33%)                               
      Lens, Cataract, Multifocal                                                 1 (100%)                                           
      Retina, Atrophy, Multifocal                                                1 (100%)                                           
   Harderian Gland                                    (50)         (5)          (7)          (40)                                   
      Inflammation, Chronic Active, Multifocal                                   1 (14%)                                            
      Acinus, Dilatation, Diffuse                      1 (2%)                                                                       
      Acinus, Hyperplasia, Multifocal                                                         1 (3%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (6)          (10)         (49)                                   
      Amyloid Deposition, Multifocal                                             1 (10%)                                            
      Cyst                                                                                    1 (2%)                                
      Infarct, Chronic, Focal                                       1 (17%)      1 (10%)                                            
      Inflammation, Acute, Multifocal, Suppurative                  3 (50%)                                                         
      Mineralization, Focal                                         1 (17%)                                                         
      Nephropathy, Chronic, Focal                      3 (6%)                                 1 (2%)                                
      Nephropathy, Chronic, Multifocal                 2 (4%)                    3 (30%)      7 (14%)                               
      Bilateral, Hydronephrosis, Acute, Multifocal     1 (2%)                                                                       
      Cortex, Inflammation, Chronic, Multifocal                                               1 (2%)                                
      Perivascular, Infiltration Cellular,                                                                                          
          Multifocal, Lymphocyte                                                              1 (2%)                                
      Renal Tubule, Atypia Cellular, Multifocal                                               1 (2%)                                
      Renal Tubule, Degeneration, Multifocal                                                  1 (2%)                                
      Renal Tubule, Pigmentation, Hemosiderin,                                                                                      
           Multifocal                                                                         4 (8%)                                
      Renal Tubule, Regeneration, Focal                1 (2%)                                                                       
      Renal Tubule, Regeneration, Multifocal          33 (66%)                               30 (61%)                               
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   13                                                              
NTP Experiment-Test: 05020-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 19:58:17  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      3 MG/KG      10 MG/KG     30 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
   Urinary Bladder                                    (49)         (8)          (11)         (50)                                   
      Dilatation                                       1 (2%)                    4 (36%)                                            
      Dilatation, Diffuse                                           7 (88%)                                                         
      Submucosa, Congestion, Multifocal                1 (2%)                                                                       
      Submucosa, Necrosis, Acute, Multifocal                                                  1 (2%)                                
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   14                                                              
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                             ----------              END OF REPORT             ----------                                           
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