National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/2866

TR 351 Mouse Pathology Tables


                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                         PARA-CHLOROANILINE


NTP Experiment-Test: 05020-02                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/03/94
Route: GAVAGE                                                                                                     Time: 19:58:22




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  106-47-8

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05020-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 19:58:22  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        VEHICLE      3 MG/KG      10 MG/KG     30 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund                                           5            4            3            4                                     
    Dead                                               5            1            3            5                                     
    Dosing Accident                                    1            3                                                               
  Survivors                                                                                                                         
    Terminal Sacrifice                                39           42           44           41                                     
  Animals Examined Microscopically                    50           50           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (47)         (3)          (2)          (46)                                   
   Intestine Small, Jejunum                           (46)         (4)          (2)          (48)                                   
   Liver                                              (50)         (50)         (50)         (50)                                   
      Carcinoma, Metastatic, Islets, Pancreatic                                  1 (2%)                                             
      Hemangiosarcoma                                  1 (2%)                                 1 (2%)                                
      Hepatocellular Carcinoma                         1 (2%)       2 (4%)                    3 (6%)                                
      Hepatocellular Carcinoma, Multiple                                                      2 (4%)                                
      Hepatocellular Adenoma                           5 (10%)      6 (12%)      6 (12%)      8 (16%)                               
      Hepatocellular Adenoma, Multiple                              1 (2%)       2 (4%)                                             
   Mesentery                                          (2)          (2)          (3)          (3)                                    
   Pancreas                                           (48)         (7)          (5)          (49)                                   
   Salivary Glands                                    (47)         (5)          (3)          (48)                                   
   Stomach, Forestomach                               (48)         (5)          (3)          (46)                                   
      Squamous Cell Papilloma                          1 (2%)       1 (20%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (5)          (3)          (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (50)         (5)          (4)          (49)                                   
      Capsule, Adenoma                                 2 (4%)                                                                       
   Adrenal Gland, Cortex                              (50)         (5)          (4)          (49)                                   
   Adrenal Gland, Medulla                             (50)         (5)          (4)          (49)                                   
      Pheochromocytoma Malignant                                                 1 (25%)                                            
      Pheochromocytoma Benign                          2 (4%)                                                                       
   Islets, Pancreatic                                 (48)         (5)          (4)          (49)                                   
      Carcinoma                                                                  1 (25%)                                            
   Pituitary Gland                                    (46)         (5)          (6)          (42)                                   
                                                             Page   2                                                               
NTP Experiment-Test: 05020-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 19:58:22  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        VEHICLE      3 MG/KG      10 MG/KG     30 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
      Pars Distalis, Adenoma                           3 (7%)       1 (20%)      2 (33%)      3 (7%)                                
   Thyroid Gland                                      (49)         (4)          (3)          (49)                                   
      Follicular Cell, Adenoma                         3 (6%)                                 2 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (50)         (14)         (17)         (47)                                   
      Cystadenoma                                      1 (2%)                                 1 (2%)                                
      Fibrosarcoma, Metastatic, Skin                                                          1 (2%)                                
      Granulosa Cell Tumor Benign                      1 (2%)                                                                       
      Follicle, Adenoma                                1 (2%)                                                                       
   Uterus                                             (50)         (38)         (42)         (48)                                   
      Hemangioma                                       1 (2%)                                                                       
      Polyp                                                                      1 (2%)                                             
      Polyp Stromal                                    1 (2%)       1 (3%)                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Blood                                              (1)                       (2)          (3)                                    
   Bone Marrow                                        (48)         (5)          (3)          (49)                                   
   Lymph Node                                         (48)         (5)          (7)          (47)                                   
      Mediastinal, Fibrosarcoma, Metastatic, Skin                                             1 (2%)                                
      Renal, Fibrosarcoma, Metastatic, Skin            1 (2%)                                                                       
   Lymph Node, Mandibular                             (46)         (5)          (5)          (47)                                   
   Lymph Node, Mesenteric                             (8)                       (4)          (3)                                    
   Spleen                                             (50)         (50)         (50)         (49)                                   
      Hemangiosarcoma                                  1 (2%)       1 (2%)       1 (2%)                                             
   Thymus                                             (41)         (4)          (1)          (35)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (38)         (5)          (3)          (44)                                   
      Adenocarcinoma                                                1 (20%)                                                         
      Adenoma                                                       1 (20%)                                                         
   Skin                                               (50)         (7)          (7)          (49)                                   
      Subcutaneous Tissue, Fibrosarcoma                1 (2%)                    3 (43%)      3 (6%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   3                                                               
NTP Experiment-Test: 05020-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 19:58:22  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        VEHICLE      3 MG/KG      10 MG/KG     30 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (49)         (6)          (3)          (50)                                   
      Cranium, Osteoma                                              1 (17%)                                                         
      Sacrum, Osteosarcoma                                                                    1 (2%)                                
   Skeletal Muscle                                    (1)                                    (1)                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (48)         (5)          (3)          (49)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (8)          (7)          (50)                                   
      Alveolar/Bronchiolar Adenoma                     5 (10%)      2 (25%)      1 (14%)      2 (4%)                                
      Alveolar/Bronchiolar Carcinoma                   1 (2%)       1 (13%)                   2 (4%)                                
      Carcinoma, Metastatic, Islets, Pancreatic                                  1 (14%)                                            
      Fibrosarcoma, Metastatic, Skin                   1 (2%)                                                                       
      Hepatocellular Carcinoma, Metastatic, Liver                   1 (13%)                   2 (4%)                                
      Pheochromocytoma Malignant, Metastatic,                                                                                       
          Adrenal Gland                                                          1 (14%)                                            
      Mediastinum, Fibrosarcoma, Metastatic, Skin                                             1 (2%)                                
   Nose                                               (50)         (5)          (3)          (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (48)         (4)          (3)          (47)                                   
      Adenoma                                          3 (6%)       1 (25%)      1 (33%)      4 (9%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (7)          (4)          (49)                                   
      Renal Tubule, Adenoma                                                                   1 (2%)                                
   Urinary Bladder                                    (48)         (5)          (3)          (44)                                   
      Fibrosarcoma, Metastatic, Skin                   1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Lymphoma Malignant Histiocytic                   3 (6%)       3 (6%)       1 (2%)       2 (4%)                                
      Lymphoma Malignant Lymphocytic                  10 (20%)      8 (16%)      3 (6%)       5 (10%)                               
      Lymphoma Malignant Mixed                         6 (12%)      1 (2%)                    3 (6%)                                
      Lymphoma Malignant Undifferentiated Cell         1 (2%)                    1 (2%)                                             
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   4                                                               
NTP Experiment-Test: 05020-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 19:58:22  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        VEHICLE      3 MG/KG      10 MG/KG     30 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SYSTEMIC LESIONS - cont                                                                                                            
   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
____________________________________________________________________________________________________________________________________
                                                             Page   5                                                               
NTP Experiment-Test: 05020-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 19:58:22  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        VEHICLE      3 MG/KG      10 MG/KG     30 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            36          26          21          31                                       
     Total Primary Neoplasms                           54          32          24          44                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 20          15          12          17                                       
     Total Benign Neoplasms                            29          15          13          22                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              24          16          10          21                                       
     Total Malignant Neoplasms                         25          17          11          22                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              1           1           2           4                                       
     Total Metastatic Neoplasm                          3           1           3           5                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   6                                                               
NTP Experiment-Test: 05020-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 19:58:22  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          VEHICLE      3 MG/KG      10 MG/KG     30 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund                                           3            6           12            9                                     
    Dead                                               4            7            9            6                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                43           36           29           35                                     
  Missing                                                           1                                                               
  Animals Examined Microscopically                    50           49           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (45)                      (4)          (47)                                   
   Intestine Large, Colon                             (48)         (6)          (7)          (48)                                   
      Cholangiocarcinoma, Metastatic, Liver                         1 (17%)                                                         
   Intestine Small, Duodenum                          (48)         (2)          (6)          (45)                                   
   Intestine Small, Jejunum                           (47)         (4)          (8)          (47)                                   
      Adenocarcinoma                                   1 (2%)                                                                       
   Liver                                              (50)         (49)         (50)         (50)                                   
      Cholangiocarcinoma                                            1 (2%)                                                          
      Hemangiosarcoma                                  2 (4%)       1 (2%)       1 (2%)       3 (6%)                                
      Hemangiosarcoma, Multiple                                     1 (2%)                    3 (6%)                                
      Hepatocellular Carcinoma                         2 (4%)       7 (14%)      8 (16%)     13 (26%)                               
      Hepatocellular Carcinoma, Multiple               1 (2%)                    3 (6%)       4 (8%)                                
      Hepatocellular Adenoma                           7 (14%)     11 (22%)      8 (16%)      3 (6%)                                
      Hepatocellular Adenoma, Multiple                 2 (4%)       4 (8%)       2 (4%)       1 (2%)                                
      Hepatocholangiocarcinoma                                                   1 (2%)                                             
   Mesentery                                          (1)                                                                           
   Pancreas                                           (49)         (3)          (7)          (49)                                   
      Hemangiosarcoma                                                                         1 (2%)                                
   Salivary Glands                                    (50)         (5)          (7)          (49)                                   
   Stomach, Forestomach                               (49)         (5)          (7)          (48)                                   
      Squamous Cell Papilloma                          2 (4%)                                                                       
   Stomach, Glandular                                 (50)         (5)          (7)          (48)                                   
      Adenocarcinoma                                                                          1 (2%)                                
      Serosa, Fibrosarcoma, Metastatic, Skin                                                  1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (5)          (8)          (50)                                   
      Fibrosarcoma, Multiple, Metastatic, Skin                                                1 (2%)                                
      Epicardium, Sarcoma                                                        1 (13%)                                            
____________________________________________________________________________________________________________________________________
                                                             Page   7                                                               
NTP Experiment-Test: 05020-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 19:58:22  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          VEHICLE      3 MG/KG      10 MG/KG     30 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (49)         (5)          (7)          (50)                                   
      Capsule, Adenoma                                                                        2 (4%)                                
   Adrenal Gland, Cortex                              (49)         (5)          (7)          (50)                                   
      Fibrosarcoma, Metastatic, Skin                                                          1 (2%)                                
   Adrenal Gland, Medulla                             (49)         (4)          (7)          (50)                                   
   Pituitary Gland                                    (40)         (4)          (4)          (41)                                   
   Thyroid Gland                                      (50)         (5)          (7)          (48)                                   
      C-Cell, Adenoma                                               1 (20%)                                                         
      Follicular Cell, Adenoma                         4 (8%)                                 3 (6%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (49)         (5)          (7)          (49)                                   
   Prostate                                           (48)         (4)          (7)          (50)                                   
   Testes                                             (49)         (5)          (7)          (50)                                   
      Interstitial Cell, Adenoma                       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Blood                                              (2)                       (2)                                                 
   Bone Marrow                                        (50)         (3)          (7)          (50)                                   
      Femoral, Hemangiosarcoma                         1 (2%)                                 2 (4%)                                
   Lymph Node                                         (49)         (25)         (28)         (49)                                   
   Lymph Node, Mandibular                             (48)         (8)          (9)          (49)                                   
      Mast Cell Tumor Benign                                                                  1 (2%)                                
      Melanoma Malignant, Metastatic, Skin                          1 (13%)                                                         
      Mediastinal, Fibrosarcoma, Metastatic, Skin                                             1 (2%)                                
   Lymph Node, Mesenteric                             (22)         (19)         (20)         (17)                                   
      Hemangiosarcoma                                  1 (5%)                                                                       
   Spleen                                             (50)         (47)         (49)         (49)                                   
      Hemangiosarcoma                                  3 (6%)       2 (4%)                    5 (10%)                               
   Thymus                                             (36)                      (3)          (27)                                   
      Sarcoma, Metastatic, Uncertain Primary Site                                1 (33%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   8                                                               
NTP Experiment-Test: 05020-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 19:58:22  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          VEHICLE      3 MG/KG      10 MG/KG     30 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (49)         (27)         (28)         (49)                                   
      Basosquamous Tumor Benign                                                               1 (2%)                                
      Squamous Cell Papilloma                                                    1 (4%)                                             
      Subcutaneous Tissue, Fibroma                     3 (6%)       4 (15%)      5 (18%)      1 (2%)                                
      Subcutaneous Tissue, Fibrosarcoma                6 (12%)      3 (11%)      8 (29%)      4 (8%)                                
      Subcutaneous Tissue, Fibrosarcoma, Multiple                                1 (4%)                                             
      Subcutaneous Tissue, Melanoma Malignant                       1 (4%)                                                          
      Subcutaneous Tissue, Sarcoma                                               1 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                                                           (3)                                    
      Intercostal, Fibrosarcoma, Metastatic, Skin                                             1 (33%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (5)          (7)          (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (10)         (14)         (50)                                   
      Alveolar/Bronchiolar Adenoma                     4 (8%)       4 (40%)      5 (36%)      4 (8%)                                
      Alveolar/Bronchiolar Adenoma, Multiple           1 (2%)                                                                       
      Alveolar/Bronchiolar Carcinoma                   3 (6%)       1 (10%)      3 (21%)      3 (6%)                                
      Fibrosarcoma, Multiple, Metastatic, Skin                                                1 (2%)                                
      Hemangiosarcoma, Metastatic, Liver                                                      1 (2%)                                
      Hepatocellular Carcinoma, Metastatic, Liver      1 (2%)       1 (10%)      2 (14%)      9 (18%)                               
      Hepatocholangiocarcinoma, Metastatic, Liver                                1 (7%)                                             
      Melanoma Malignant, Metastatic, Skin                          1 (10%)                                                         
      Mediastinum, Sarcoma                                                       1 (7%)                                             
   Nose                                               (50)         (5)          (7)          (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (50)         (5)          (7)          (40)                                   
      Adenoma                                          5 (10%)      2 (40%)      1 (14%)      4 (10%)                               
      Adenoma, Multiple                                                                       1 (3%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   9                                                               
NTP Experiment-Test: 05020-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 19:58:22  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          VEHICLE      3 MG/KG      10 MG/KG     30 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (6)          (10)         (49)                                   
   Urinary Bladder                                    (49)         (8)          (11)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(49)        *(50)        *(50)                                   
      Lymphoma Malignant Histiocytic                   3 (6%)       1 (2%)       1 (2%)                                             
      Lymphoma Malignant Lymphocytic                   2 (4%)       2 (4%)       8 (16%)                                            
      Lymphoma Malignant Mixed                         5 (10%)                                3 (6%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  10                                                               
NTP Experiment-Test: 05020-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 19:58:22  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          VEHICLE      3 MG/KG      10 MG/KG     30 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            40          30          35          36                                       
     Total Primary Neoplasms                           59          46          59          63                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 23          20          17          18                                       
     Total Benign Neoplasms                            29          26          22          21                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              25          16          28          27                                       
     Total Malignant Neoplasms                         30          20          37          42                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              1           2           3          10                                       
     Total Metastatic Neoplasm                          1           4           4          16                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                       1                                                   
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  11                                                               
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