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TR 351 Rat Pathology Tables

NTP Experiment-Test: 05020-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97
Route: GAVAGE                                                                                                     Time: 13:14:36




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  000106478

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































Note:  Animals arranged according to CID number

                                                              Page   1

NTP Experiment-Test: 05020-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:14:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 7| 1| 6| 7| 7| 7| 4| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 3| 7| 2| 7| 7|             
                             DAY ON TEST   | 1| 5| 3| 8| 1| 3| 3| 3| 8| 3| 3| 3| 2| 2| 3| 3| 2| 3| 3| 1| 6| 3| 0| 0| 2|             
                                           | 9| 7| 2| 9| 8| 1| 0| 2| 2| 1| 0| 7| 8| 9| 1| 7| 9| 0| 2| 4| 9| 1| 0| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    VEHICLE                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  A  +  +  A  A  +  +  +  +  +  +  +  A  +  +  +  M|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma, Metastatic, Uterus   |                                                                      X   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | A  +  +  +  +  +  +  +  A  +  +  A  M  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  A  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X                       X        X                    X     X     X   |             
      Neoplastic Nodule                    |                                                                          |             
      Artery, Adenocarcinoma, Metastatic,  |                                                                          |             
           Uterus                          |                                                                      X   |             
                                            __________________________________________________________________________|             
   Mesentery                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Adenocarcinoma, Metastatic, Uterus   |                                                                      X   |             
      Leukemia Mononuclear                 |                                     X                    X           X   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma, Metastatic, Uterus   |                                                                      X   |             
      Leukemia Mononuclear                 |                                                          X               |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma, Metastatic, Uterus   |                                                                      X   |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |             +                                                        +   |             
      Squamous Cell Papilloma              |             X                                                        X   |             
                                            __________________________________________________________________________|             
   Tooth                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                     X                    X               |             
      Capsule, Adenocarcinoma, Metastatic, |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05020-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:14:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 7| 1| 6| 7| 7| 7| 4| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 3| 7| 2| 7| 7|             
                             DAY ON TEST   | 1| 5| 3| 8| 1| 3| 3| 3| 8| 3| 3| 3| 2| 2| 3| 3| 2| 3| 3| 1| 6| 3| 0| 0| 2|             
                                           | 9| 7| 2| 9| 8| 1| 0| 2| 2| 1| 0| 7| 8| 9| 1| 7| 9| 0| 2| 4| 9| 1| 0| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    VEHICLE                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
           Uterus                          |                                                                      X   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                     X                    X               |             
      Pheochromocytoma Benign              |    X                                                           X         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                         X|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  M  +  +  +  +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                     X                                    |             
      Pars Distalis, Adenoma               |             X           X     X              X                 X        X|             
      Pars Distalis, Adenoma, Multiple     |                   X                                                      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Bilateral, C-Cell, Adenoma           |                                        X                                 |             
      C-Cell, Adenoma                      |                X                 X                    X                  |             
      C-Cell, Carcinoma                    |                                                          X               |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Adenoma                              |                               X                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                          X               |             
      Bilateral, Adenocarcinoma,           |                                                                          |             
          Metastatic, Uterus               |                                                                      X   |             
                                            __________________________________________________________________________|             
   Oviduct                                 | +  +  +  +     +  +  +     +        +  +  +     +  +  +  +     +     +  +|             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma                       |                                                                      X   |             
      Leukemia Mononuclear                 |                                                                          |             
      Polyp Stromal                        |                                                                      X   |             
      Polyp Stromal, Multiple              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |       +  +  +  +  +  +     +  +        +  +     +  +  +  +     +  +      |             
      Leukemia Mononuclear                 |                            X                             X     X         |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femoral, Leukemia Mononuclear        |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inguinal, Leukemia Mononuclear       |                                                          X               |             
      Mediastinal, Adenocarcinoma,         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05020-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:14:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 7| 1| 6| 7| 7| 7| 4| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 3| 7| 2| 7| 7|             
                             DAY ON TEST   | 1| 5| 3| 8| 1| 3| 3| 3| 8| 3| 3| 3| 2| 2| 3| 3| 2| 3| 3| 1| 6| 3| 0| 0| 2|             
                                           | 9| 7| 2| 9| 8| 1| 0| 2| 2| 1| 0| 7| 8| 9| 1| 7| 9| 0| 2| 4| 9| 1| 0| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    VEHICLE                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
          Metastatic, Uterus               |                                                                      X   |             
      Mediastinal, Leukemia Mononuclear    |                                     X                    X           X   |             
      Renal, Leukemia Mononuclear          |                                     X                                    |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                     X                    X               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                                     +                    +        +     +|             
      Leukemia Mononuclear                 |                                     X                    X               |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma, Metastatic, Uterus   |                                                                      X   |             
      Leukemia Mononuclear                 |    X                       X        X                    X     X     X   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  M  +  +  +  +  M  +  +  +  M  M  +  +  +  +  M  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                          X               |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Fibroadenoma                         |                                                    X                    X|             
      Fibroadenoma, Multiple               |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basosquamous Tumor Benign            |    X                                                                     |             
      Leukemia Mononuclear                 |                                                                          |             
      Subcutaneous Tissue, Fibroma         |       X                                                                  |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Astrocytoma Benign                   |                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                   +      |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |          +                                                  +     +      |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma, Metastatic, Uterus   |                                                                      X   |             
      Leukemia Mononuclear                 |    X                                X                    X     X     X   |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05020-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:14:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 7| 1| 6| 7| 7| 7| 4| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 3| 7| 2| 7| 7|             
                             DAY ON TEST   | 1| 5| 3| 8| 1| 3| 3| 3| 8| 3| 3| 3| 2| 2| 3| 3| 2| 3| 3| 1| 6| 3| 0| 0| 2|             
                                           | 9| 7| 2| 9| 8| 1| 0| 2| 2| 1| 0| 7| 8| 9| 1| 7| 9| 0| 2| 4| 9| 1| 0| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    VEHICLE                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                +  +        +           +  +  +                           |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  M  +  +  +  M  +  +  M  +  M  +  +  +  +  +  +  M  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma, Metastatic, Uterus   |                                                                      X   |             
      Leukemia Mononuclear                 |                                     X                    X           X   |             
                                            __________________________________________________________________________|             
   Ureter                                  | +        +  +     +  +     +     +  +     +  +           +           +   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X                       X        X                    X     X     X   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05020-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:14:36  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 6| 7| 6| 6| 7| 5| 5| 7| 7| 7| 7| 7| 4| 7| 7| 7| 6| 7| 2| 0| 7| 7|            |
                             DAY ON TEST   | 3| 0| 2| 6| 3| 1| 3| 2| 4| 2| 3| 3| 3| 3| 2| 0| 3| 3| 3| 5| 3| 0| 8| 3| 3|            |
                                           | 0| 5| 9| 2| 1| 2| 0| 9| 4| 9| 0| 2| 2| 2| 9| 0| 2| 0| 2| 8| 2| 9| 0| 0| 1|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|     A      |
    VEHICLE                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  A  +  +  +  A  +  A  +  +  +|  40        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Adenocarcinoma, Metastatic, Uterus   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  A  +  +  +|  40        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +|  43        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |          X              X  X                             X               |         10 |
      Neoplastic Nodule                    |                                                       X                  |          1 |
      Artery, Adenocarcinoma, Metastatic,  |                                                                          |            |
           Uterus                          |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Adenocarcinoma, Metastatic, Uterus   |                                                                          |          1 |
      Leukemia Mononuclear                 |                         X                                X               |          5 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenocarcinoma, Metastatic, Uterus   |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                          X               |          2 |
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                                                   +      |   1        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                          X               |          1 |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                          X               |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenocarcinoma, Metastatic, Uterus   |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                          X               |          1 |
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                   +      |   3        |
      Squamous Cell Papilloma              |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Tooth                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                            X                                             |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page   6                                                               
NTP Experiment-Test: 05020-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:14:36  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 6| 7| 6| 6| 7| 5| 5| 7| 7| 7| 7| 7| 4| 7| 7| 7| 6| 7| 2| 0| 7| 7|            |
                             DAY ON TEST   | 3| 0| 2| 6| 3| 1| 3| 2| 4| 2| 3| 3| 3| 3| 2| 0| 3| 3| 3| 5| 3| 0| 8| 3| 3|            |
                                           | 0| 5| 9| 2| 1| 2| 0| 9| 4| 9| 0| 2| 2| 2| 9| 0| 2| 0| 2| 8| 2| 9| 0| 0| 1|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|     A      |
    VEHICLE                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                         X                                X               |          4 |
      Capsule, Adenocarcinoma, Metastatic, |                                                                          |            |
           Uterus                          |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                         X                                X               |          4 |
      Pheochromocytoma Benign              |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenoma                              |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                          X               |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +|  42        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Pars Distalis, Adenoma               | X  X  X  X  X  X  X        X     X  X     X           X     X           X|         20 |
      Pars Distalis, Adenoma, Multiple     |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |                         X                                                |          1 |
      Bilateral, C-Cell, Adenoma           |                                                                          |          1 |
      C-Cell, Adenoma                      |                                        X                                 |          4 |
      C-Cell, Carcinoma                    |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +|  45        |
      Adenoma                              |                                                                          |          1 |
      Leukemia Mononuclear                 |                         X                                                |          1 |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                         X                                X               |          3 |
      Bilateral, Adenocarcinoma,           |                                                                          |            |
          Metastatic, Uterus               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Oviduct                                 | +  M  +  +  +  M  M  +  M  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|  38        |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenocarcinoma                       |                                                                          |          1 |
      Leukemia Mononuclear                 |                         X                                X               |          2 |
      Polyp Stromal                        |                   X        X                                         X   |          4 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page   7                                                               
NTP Experiment-Test: 05020-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:14:36  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 6| 7| 6| 6| 7| 5| 5| 7| 7| 7| 7| 7| 4| 7| 7| 7| 6| 7| 2| 0| 7| 7|            |
                             DAY ON TEST   | 3| 0| 2| 6| 3| 1| 3| 2| 4| 2| 3| 3| 3| 3| 2| 0| 3| 3| 3| 5| 3| 0| 8| 3| 3|            |
                                           | 0| 5| 9| 2| 1| 2| 0| 9| 4| 9| 0| 2| 2| 2| 9| 0| 2| 0| 2| 8| 2| 9| 0| 0| 1|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|     A      |
    VEHICLE                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Polyp Stromal, Multiple              |             X                                                            |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   | +     +     +        +     +  +  +  +  +  +     +  +  +     +        +  +|  32        |
      Leukemia Mononuclear                 |                            X                                             |          4 |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Femoral, Leukemia Mononuclear        |                         X  X                                             |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inguinal, Leukemia Mononuclear       |                                                                          |          1 |
      Mediastinal, Adenocarcinoma,         |                                                                          |            |
          Metastatic, Uterus               |                                                                          |          1 |
      Mediastinal, Leukemia Mononuclear    |          X              X  X                             X               |          7 |
      Renal, Leukemia Mononuclear          |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |          X              X                                X               |          5 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                   +                                   +        +         |   7        |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenocarcinoma, Metastatic, Uterus   |                                                                          |          1 |
      Leukemia Mononuclear                 |          X              X  X                             X               |         10 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  42        |
      Leukemia Mononuclear                 |                         X                                                |          2 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Adenoma                              |    X                                                                     |          1 |
      Fibroadenoma                         |       X     X                                X        X                  |          6 |
      Fibroadenoma, Multiple               |                                  X                                      X|          2 |
      Leukemia Mononuclear                 |                         X                                                |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basosquamous Tumor Benign            |                                                                          |          1 |
      Leukemia Mononuclear                 |                         X                                                |          1 |
      Subcutaneous Tissue, Fibroma         | X                                                                        |          2 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |                         X                                                |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page   8                                                               
NTP Experiment-Test: 05020-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:14:36  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 6| 7| 6| 6| 7| 5| 5| 7| 7| 7| 7| 7| 4| 7| 7| 7| 6| 7| 2| 0| 7| 7|            |
                             DAY ON TEST   | 3| 0| 2| 6| 3| 1| 3| 2| 4| 2| 3| 3| 3| 3| 2| 0| 3| 3| 3| 5| 3| 0| 8| 3| 3|            |
                                           | 0| 5| 9| 2| 1| 2| 0| 9| 4| 9| 0| 2| 2| 2| 9| 0| 2| 0| 2| 8| 2| 9| 0| 0| 1|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|     A      |
    VEHICLE                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Astrocytoma Benign                   | X                                                                        |          1 |
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                                              +                 +         |   3        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                              +                 +         |   5        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Adenocarcinoma, Metastatic, Uterus   |                                                                          |          1 |
      Leukemia Mononuclear                 |          X              X  X                             X               |          9 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |                                                          X               |          1 |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     | +     +     +              +                    +  +                     |  12        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  M  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  42        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenocarcinoma, Metastatic, Uterus   |                                                                          |          1 |
      Leukemia Mononuclear                 |                         X  X                             X               |          6 |
                                            __________________________________________________________________________|____________|
   Ureter                                  |          +           +           +                 +                    +|  17        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |          X              X  X                             X               |         10 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page   9                                                               
NTP Experiment-Test: 05020-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:14:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 1| 7| 7|             
                             DAY ON TEST   | 2| 2| 3| 0| 3| 3| 3| 2| 6| 2| 2| 3| 3| 3| 3| 3| 3| 3| 8| 2| 3| 2| 4| 1| 3|             
                                           | 9| 9| 1| 5| 2| 0| 0| 3| 4| 9| 9| 0| 2| 1| 1| 0| 2| 1| 8| 9| 1| 9| 0| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    2 MG/KG                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |          +                                                        +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large                         |          +                                                        +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |          +                                                        M      |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |          +                                                        +      |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |          +                                                        M      |             
                                            __________________________________________________________________________|             
   Intestine Small                         |          +                                                        +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |          +                                                        M      |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |          +                                                        M      |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |          +                                                        +      |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Neoplastic Nodule                    |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |          +                                                     +  +      |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |          +                                                        +      |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |          +           +  +                                         +  +   |             
      Carcinoma, Metastatic, Zymbal's Gland|                      X                                                   |             
                                            __________________________________________________________________________|             
   Stomach                                 |          +                                                        +      |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |          +                                                        +      |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |          +                                                        +      |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |          +                                                               |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |          +                                                        +  +   |             
                                            __________________________________________________________________________|             
   Heart                                   |          +                                                        +  +   |             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Pheochromocytoma Benign              |                                  X              X                        |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |          +                                                        +      |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |          +                                                        +      |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +        +        +  +  +  +        +  +  +  +     +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  10                                                               
NTP Experiment-Test: 05020-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:14:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 1| 7| 7|             
                             DAY ON TEST   | 2| 2| 3| 0| 3| 3| 3| 2| 6| 2| 2| 3| 3| 3| 3| 3| 3| 3| 8| 2| 3| 2| 4| 1| 3|             
                                           | 9| 9| 1| 5| 2| 0| 0| 3| 4| 9| 9| 0| 2| 1| 1| 0| 2| 1| 8| 9| 1| 9| 0| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    2 MG/KG                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Distalis, Adenoma               | X  X  X  X                       X              X           X        X   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |          +                                                        +      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |          M                                                  +     M      |             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   |          +  +                       +        +     +              +      |             
      Granulosa-Theca Tumor Benign         |             X                                                            |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Oviduct                                 |                                     +        +     +              +      |             
                                            __________________________________________________________________________|             
   Uterus                                  |    +     +                    +                                   +      |             
      Adenocarcinoma                       |                                                                          |             
      Polyp Stromal                        |                               X                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +        +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +     +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +|             
      Femoral, Leukemia Mononuclear        |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |          +           +  +                                         +  +   |             
      Mediastinal, Leukemia Mononuclear    |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |          +              +                                         +  +   |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                                                                      M   |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |          +                                                        +  +   |             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |          +                    +                             +     M      |             
      Adenoma                              |                                                             X            |             
      Fibroadenoma                         |                                                                          |             
      Fibroadenoma, Multiple               |                               X                                          |             
                                            __________________________________________________________________________|             
   Skin                                    |       +  +           +        +                       +     +     +      |             
      Subcutaneous Tissue, Fibroma         |       X  X                                                               |             
      Subcutaneous Tissue, Fibrosarcoma    |                                                       X                  |             
      Subcutaneous Tissue, Neurofibroma    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  11                                                               
NTP Experiment-Test: 05020-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:14:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 1| 7| 7|             
                             DAY ON TEST   | 2| 2| 3| 0| 3| 3| 3| 2| 6| 2| 2| 3| 3| 3| 3| 3| 3| 3| 8| 2| 3| 2| 4| 1| 3|             
                                           | 9| 9| 1| 5| 2| 0| 0| 3| 4| 9| 9| 0| 2| 1| 1| 0| 2| 1| 8| 9| 1| 9| 0| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    2 MG/KG                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +     +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |          +                                                        +      |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |          +                                                        +      |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |          +                                                        +      |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |          +                                                        M      |             
                                            __________________________________________________________________________|             
   Trachea                                 |          +                                                        M  +   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     | +  +  +     +  +  +  +     +  +           +           +        +         |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |          +                                                               |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                      +                                                   |             
      Carcinoma                            |                      X                                                   |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Lipoma                               |                                                                          |             
                                            __________________________________________________________________________|             
   Ureter                                  |    +                          +                 +           +  +     +   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |          +                                                        +      |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  12                                                               
NTP Experiment-Test: 05020-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:14:36  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 0| 2| 2| 1| 3| 2| 3| 9| 3| 3| 2| 3| 2| 2| 2|            |
                                           | 0| 0| 1| 1| 0| 2| 9| 0| 1| 2| 5| 9| 9| 7| 0| 9| 2| 3| 0| 0| 9| 0| 8| 8| 9|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     A      |
    2 MG/KG                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |                               +        +           +              +  +   |   8        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |                      +        +        +                          +  +   |   7        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                      +        +        +                             A   |   4        |
      Leukemia Mononuclear                 |                                        X                                 |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                               +        +                          +  +   |   6        |
      Leukemia Mononuclear                 |                                        X                                 |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                               +        +                             A   |   3        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                               +        +                             +   |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                               +        +                             A   |   3        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                               +        +                             A   |   3        |
      Leukemia Mononuclear                 |                                        X                                 |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                               +        +                             +   |   5        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                        X                          X      |          2 |
      Neoplastic Nodule                    |                                                    X                     |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               | +                             +        +                          +      |   7        |
      Leukemia Mononuclear                 |                                        X                          X      |          2 |
                                            __________________________________________________________________________|____________|
   Pancreas                                |                               +        +                          +  +   |   6        |
      Leukemia Mononuclear                 |                                        X                                 |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                               +        +                             +   |   8        |
      Carcinoma, Metastatic, Zymbal's Gland|                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach                                 |                               +        +                             +   |   5        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                               +        +                             +   |   5        |
      Leukemia Mononuclear                 |                                        X                                 |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                               +        +                             A   |   4        |
      Leukemia Mononuclear                 |                                        X                                 |          1 |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                               +        +                             +   |   4        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |    +                          +        +                          +  +   |   8        |
                                            __________________________________________________________________________|____________|
   Heart                                   |                               +        +                    +        +   |   7        |
      Leukemia Mononuclear                 |                                        X                                 |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenoma                              |                                                          X               |          1 |
      Leukemia Mononuclear                 |                                                                   X      |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  13                                                               
NTP Experiment-Test: 05020-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:14:36  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 0| 2| 2| 1| 3| 2| 3| 9| 3| 3| 2| 3| 2| 2| 2|            |
                                           | 0| 0| 1| 1| 0| 2| 9| 0| 1| 2| 5| 9| 9| 7| 0| 9| 2| 3| 0| 0| 9| 0| 8| 8| 9|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     A      |
    2 MG/KG                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Leukemia Mononuclear                 |                                                                   X      |          1 |
      Pheochromocytoma Benign              |                                                          X               |          3 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                               +        +                             +   |   5        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                               +        +                             M   |   4        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |       +  +  +     +  +     +  +        +  +  +     +  +  +        +  +   |  33        |
      Pars Distalis, Adenoma               |                               X           X  X     X     X               |         13 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                               +        +           +                 +   |   6        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |                               +        M                 +        +  +   |   5        |
      Adenoma                              |                                                          X               |          1 |
                                            __________________________________________________________________________|____________|
   Ovary                                   |    +     +     +              +  +     +                    +  +     +   |  15        |
      Granulosa-Theca Tumor Benign         |                X                                                         |          2 |
      Leukemia Mononuclear                 |                                        X                                 |          1 |
                                            __________________________________________________________________________|____________|
   Oviduct                                 |    +     +     +                 +                          +  +         |  10        |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +     +        M           +  +  +     +  +        +              +  +   |  14        |
      Adenocarcinoma                       |                                           X                              |          1 |
      Polyp Stromal                        | X     X                          X                 X              X      |          6 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +|  45        |
      Leukemia Mononuclear                 |                                        X                          X      |          2 |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Femoral, Leukemia Mononuclear        |                                        X                                 |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +                 +        +        +                 +        +  +   |  12        |
      Mediastinal, Leukemia Mononuclear    |                                                                   X      |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                               +        +                             +   |   7        |
      Leukemia Mononuclear                 |                                        X                                 |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                      +                 +                 +        +      |   4        |
      Leukemia Mononuclear                 |                                        X                          X      |          2 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                        X                          X      |          2 |
                                            __________________________________________________________________________|____________|
   Thymus                                  |    +                          +        +                          +  +   |   8        |
      Leukemia Mononuclear                 |                                        X                          X      |          2 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  14                                                               
NTP Experiment-Test: 05020-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:14:36  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 0| 2| 2| 1| 3| 2| 3| 9| 3| 3| 2| 3| 2| 2| 2|            |
                                           | 0| 0| 1| 1| 0| 2| 9| 0| 1| 2| 5| 9| 9| 7| 0| 9| 2| 3| 0| 0| 9| 0| 8| 8| 9|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|     A      |
    2 MG/KG                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |    +        +  +     +  +     +        +     +  +     +  +        +  +  +|  17        |
      Adenoma                              |                                                                          |          1 |
      Fibroadenoma                         |    X        X  X     X                       X  X     X                 X|          8 |
      Fibroadenoma, Multiple               |                         X                                                |          2 |
                                            __________________________________________________________________________|____________|
   Skin                                    |    +        +  +     +  +     +        +     +  +  +  +              +  +|  20        |
      Subcutaneous Tissue, Fibroma         |                                                                          |          2 |
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |          1 |
      Subcutaneous Tissue, Neurofibroma    |                                                    X                     |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                               +        +                             +   |   5        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                               +        +                             +   |   5        |
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                      +   |   1        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                      +   |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |                               +        +                             +   |   5        |
      Leukemia Mononuclear                 |                                        X                                 |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    |                               +        +                             +   |   4        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |    +                          +        +           +              +  +   |   8        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     | +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +  +  +         |  32        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |             +                 +        +  +                          +   |   6        |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                              +                           |   2        |
      Carcinoma                            |                                              X                           |          2 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                        X                                 |          1 |
      Lipoma                               |             X                                                            |          1 |
                                            __________________________________________________________________________|____________|
   Ureter                                  |                               +        +           +  +        +     +   |  12        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                               +        +                             +   |   5        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                        X                          X      |          2 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  15                                                               
NTP Experiment-Test: 05020-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:14:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 7| 3| 3| 3| 3| 2| 3| 4| 3| 1| 3| 3| 3| 3| 3| 3| 9| 0| 2| 3| 3| 3| 0|             
                                           | 0| 1| 7| 2| 0| 0| 2| 9| 0| 4| 2| 9| 0| 2| 1| 2| 0| 1| 5| 5| 9| 1| 2| 1| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    18 MG/KG                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Sarcoma, Metastatic, Skin            |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               | +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
      Adenocarcinoma, Metastatic, Uterus   |                                                                         X|             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma, Metastatic, Uterus   |                                                                         X|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Tooth                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Pheochromocytoma Benign              | X                                            X                           |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Adenoma                              |                                                 X                        |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               |    X  X           X     X           X  X     X           X        X  X   |             
      Pars Distalis, Adenoma, Multiple     |                                                 X                        |             
      Pars Distalis, Carcinoma             |                            X                                             |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      C-Cell, Adenoma                      |                X                    X                                    |             
      C-Cell, Carcinoma                    |                                                                          |             
      Follicular Cell, Adenoma             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  16                                                               
NTP Experiment-Test: 05020-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:14:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 7| 3| 3| 3| 3| 2| 3| 4| 3| 1| 3| 3| 3| 3| 3| 3| 9| 0| 2| 3| 3| 3| 0|             
                                           | 0| 1| 7| 2| 0| 0| 2| 9| 0| 4| 2| 9| 0| 2| 1| 2| 0| 1| 5| 5| 9| 1| 2| 1| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    18 MG/KG                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                X         |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Oviduct                                 |    +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma                       |                                                                         X|             
      Fibroma                              |                                                                          |             
      Polyp Stromal                        |                                           X  X                 X         |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                       +                  |             
      Polyp                                |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   | +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +   |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  I  +  +  +  A  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mediastinal, Adenocarcinoma,         |                                                                          |             
          Metastatic, Uterus               |                                                                         X|             
      Mediastinal, Sarcoma, Metastatic,    |                                                                          |             
           Skin                            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                                  +     +                    +  +  +     +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma, Metastatic, Uterus   |                                                                         X|             
      Leukemia Mononuclear                 |                                                                          |             
      Osteosarcoma                         |          X                                                               |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  M|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                     X                             X      |             
      Fibroadenoma                         |                X        X              X                                 |             
      Sarcoma, Metastatic, Skin            |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Fibroma         |                                                                          |             
      Subcutaneous Tissue, Sarcoma         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Sarcoma, Metastatic, Skin            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  17                                                               
NTP Experiment-Test: 05020-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:14:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 7| 3| 3| 3| 3| 2| 3| 4| 3| 1| 3| 3| 3| 3| 3| 3| 9| 0| 2| 3| 3| 3| 0|             
                                           | 0| 1| 7| 2| 0| 0| 2| 9| 0| 4| 2| 9| 0| 2| 1| 2| 0| 1| 5| 5| 9| 1| 2| 1| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    18 MG/KG                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma, Metastatic, Uterus   |                                                                         X|             
      Leukemia Mononuclear                 |                                                                          |             
      Sarcoma, Metastatic, Skin            |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |          +  +     +     +        +  +  +  +  +  +  +        +  +  +  +   |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma, Metastatic, Uterus   |                                                                         X|             
                                            __________________________________________________________________________|             
   Ureter                                  |          +                    +     +     +              +  +  +         |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  18                                                               
NTP Experiment-Test: 05020-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:14:36  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 5| 6| 6| 7| 7| 6| 7| 7| 5|            |
                             DAY ON TEST   | 2| 3| 3| 2| 3| 3| 2| 3| 3| 1| 2| 3| 3| 3| 2| 3| 5| 8| 6| 3| 3| 1| 3| 3| 2|            |
                                           | 9| 2| 2| 6| 0| 0| 9| 0| 2| 1| 9| 2| 1| 1| 9| 1| 2| 8| 5| 1| 0| 6| 2| 1| 9|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|     A      |
    18 MG/KG                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  A  +  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |    X                                                                     |          1 |
      Sarcoma, Metastatic, Skin            |                                                       X                  |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Adenocarcinoma, Metastatic, Uterus   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Adenocarcinoma, Metastatic, Uterus   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Tooth                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |    X                                                                     |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |    X                                                                     |          1 |
      Pheochromocytoma Benign              |                               X  X  X                    X               |          6 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Adenoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  M  +  +  +  M  +  +  +  +|  42        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Adenoma               |       X  X     X           X     X           X     X  X     X     X      |         20 |
      Pars Distalis, Adenoma, Multiple     |                      X                                   X               |          3 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  19                                                               
NTP Experiment-Test: 05020-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:14:36  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 5| 6| 6| 7| 7| 6| 7| 7| 5|            |
                             DAY ON TEST   | 2| 3| 3| 2| 3| 3| 2| 3| 3| 1| 2| 3| 3| 3| 2| 3| 5| 8| 6| 3| 3| 1| 3| 3| 2|            |
                                           | 9| 2| 2| 6| 0| 0| 9| 0| 2| 1| 9| 2| 1| 1| 9| 1| 2| 8| 5| 1| 0| 6| 2| 1| 9|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|     A      |
    18 MG/KG                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Pars Distalis, Carcinoma             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      C-Cell, Adenoma                      |                         X                                         X  X   |          5 |
      C-Cell, Carcinoma                    |                                              X                           |          1 |
      Follicular Cell, Adenoma             |                                                                         X|          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Adenoma                              |                   X                                      X     X         |          4 |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Oviduct                                 | +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +  M  +  +  M|  42        |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenocarcinoma                       |                                                                          |          1 |
      Fibroma                              |                                                                   X      |          1 |
      Polyp Stromal                        |                               X        X                             X   |          6 |
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   1        |
      Polyp                                |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +     +  +  +|  43        |
      Leukemia Mononuclear                 |    X                                                                     |          1 |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mediastinal, Adenocarcinoma,         |                                                                          |            |
          Metastatic, Uterus               |                                                                          |          1 |
      Mediastinal, Sarcoma, Metastatic,    |                                                                          |            |
           Skin                            |                                                       X                  |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |       +              +                                                  +|   9        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenocarcinoma, Metastatic, Uterus   |                                                                          |          1 |
      Leukemia Mononuclear                 |    X                                                                     |          1 |
      Osteosarcoma                         |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  M  +  +  +  +  +  +|  44        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  20                                                               
NTP Experiment-Test: 05020-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:14:36  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 5| 6| 6| 7| 7| 6| 7| 7| 5|            |
                             DAY ON TEST   | 2| 3| 3| 2| 3| 3| 2| 3| 3| 1| 2| 3| 3| 3| 2| 3| 5| 8| 6| 3| 3| 1| 3| 3| 2|            |
                                           | 9| 2| 2| 6| 0| 0| 9| 0| 2| 1| 9| 2| 1| 1| 9| 1| 2| 8| 5| 1| 0| 6| 2| 1| 9|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|     A      |
    18 MG/KG                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenoma                              |                X                                                         |          3 |
      Fibroadenoma                         |                                  X                 X              X      |          6 |
      Sarcoma, Metastatic, Skin            |                                                       X                  |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Subcutaneous Tissue, Fibroma         |                                                             X           X|          2 |
      Subcutaneous Tissue, Sarcoma         |                                                       X                  |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Sarcoma, Metastatic, Skin            |                                                       X                  |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenocarcinoma, Metastatic, Uterus   |                                                                          |          1 |
      Leukemia Mononuclear                 |    X                                                                     |          1 |
      Sarcoma, Metastatic, Skin            |                                                       X                  |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     | +           +  +  +  +  +     +  +  +     +        +  +  +  +     +  +   |  31        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M|  44        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenocarcinoma, Metastatic, Uterus   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Ureter                                  |       +                                               +                  |   9        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |    X                                                                     |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  21                                                               
NTP Experiment-Test: 05020-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:14:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 5| 7| 7|             
                             DAY ON TEST   | 8| 1| 5| 3| 2| 3| 3| 2| 3| 0| 3| 3| 3| 7| 3| 3| 3| 3| 3| 5| 2| 3| 2| 2| 2|             
                                           | 1| 1| 7| 1| 9| 0| 1| 9| 1| 5| 0| 1| 1| 4| 0| 0| 2| 0| 1| 3| 1| 2| 0| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    6 MG/KG                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +                    +     +     +     +                 +     +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +                    +     +           +                 +        +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | A                    A     +           A                 A        A      |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +                    +     +           +                 A        A      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +                    +     +           +                 A        +      |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +                    +     +           +                 +        +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | A                    +     +           +                 A        +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | A                    A     +           A                 A        A      |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | A                    A     +           +                 A        A      |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X                                                                     |             
                                            __________________________________________________________________________|             
   Mesentery                               | +                    +     +           +                 +        +      |             
      Lipoma                               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +                 +  +     +           +                 +        +      |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +                    +     +     +     +                 +  +     +      |             
                                            __________________________________________________________________________|             
   Stomach                                 | +                    +     +           +                 +        +      |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +                    +     +           +                 +        +      |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +                    +     +           +                 +        +      |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
      Squamous Cell Papilloma              |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   | +                    +     +           +                 +        +      |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +                    +     +     +     +                 +     +  +      |             
                                            __________________________________________________________________________|             
   Heart                                   | +                    +     +           +                 +        +      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X                                                                     |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X                                                                     |             
      Pheochromocytoma Benign              |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +                    +     +           +                 +        A      |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +                    +     +           +                 +        M      |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +     +  +     +     +  +  +  +  +     +  +     +  +  +  +  +     +      |             
      Pars Distalis, Adenoma               |          X     X     X           X              X  X  X  X  X     X      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +                    +     +           +                 +        +      |             
      C-Cell, Adenoma                      |                                                          X               |             
      C-Cell, Carcinoma                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  22                                                               
NTP Experiment-Test: 05020-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:14:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 5| 7| 7|             
                             DAY ON TEST   | 8| 1| 5| 3| 2| 3| 3| 2| 3| 0| 3| 3| 3| 7| 3| 3| 3| 3| 3| 5| 2| 3| 2| 2| 2|             
                                           | 1| 1| 7| 1| 9| 0| 1| 9| 1| 5| 0| 1| 1| 4| 0| 0| 2| 0| 1| 3| 1| 2| 0| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    6 MG/KG                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +                    +     +           +                 +        +      |             
      Adenoma                              |                            X                                             |             
                                            __________________________________________________________________________|             
   Ovary                                   | +           +        +     +     +     +                 +        +      |             
                                            __________________________________________________________________________|             
   Oviduct                                 |             +                    +     +                 +        +      |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +           +     +  +  +           +                 +        +      |             
      Polyp Stromal                        | X                       X  X           X                                 |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |          +  +  +  +     +  I  +  +  +     +  +  +  +  +     +  +     +  +|             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femoral, Leukemia Mononuclear        |    X                                                                     |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +     +           +  +     +     +     +                 +  +  +  +      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +     +              +     +     +     +                 +  +     +      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosarcoma                         |                                                                          |             
      Leukemia Mononuclear                 |    X                                                                     |             
                                            __________________________________________________________________________|             
   Thymus                                  | +                    +     +           +                 +     +  +      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +        +     +  +  +     +     +     +     +        +  +  +     +     +|             
      Fibroadenoma                         |                X  X              X           X        X     X           X|             
      Fibroadenoma, Multiple               |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +        +     +  +  +     +     +     +     +        +  +  +     +     +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         | +                    +     +           +                 +        +      |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +                    +     +           +                 +        +      |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +                    +     +           +                 +     +  +      |             
                                            __________________________________________________________________________|             
   Nose                                    | +                    +     +           +                 +  +     +      |             
      Osteosarcoma                         |                                                             X            |             
                                            __________________________________________________________________________|             
   Trachea                                 | +                    +     +     +     +                 +     +  +      |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |          +  +  +  +     +        +  +           +  +  +        +     +   |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +                    +     +           +                 +        +      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  23                                                               
NTP Experiment-Test: 05020-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:14:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 5| 7| 7|             
                             DAY ON TEST   | 8| 1| 5| 3| 2| 3| 3| 2| 3| 0| 3| 3| 3| 7| 3| 3| 3| 3| 3| 5| 2| 3| 2| 2| 2|             
                                           | 1| 1| 7| 1| 9| 0| 1| 9| 1| 5| 0| 1| 1| 4| 0| 0| 2| 0| 1| 3| 1| 2| 0| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    6 MG/KG                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X                                                                     |             
                                            __________________________________________________________________________|             
   Ureter                                  |                            +  +                          +           +   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +                    +     +           +                 +        M      |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X                                                                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  24                                                               
NTP Experiment-Test: 05020-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:14:36  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 0| 2| 3| 3| 3| 2| 2| 2| 3| 3| 2| 2| 3| 9| 3| 2| 3| 3| 2| 3| 2| 3| 2| 3|            |
                                           | 1| 1| 9| 2| 0| 9| 9| 9| 6| 1| 1| 9| 9| 2| 4| 0| 9| 0| 1| 9| 2| 9| 1| 9| 2|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|     A      |
    6 MG/KG                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |                +        +                 +                 +            |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +              +        +        +        +                 +            |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                A        +        +        A                 A            |   3        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +              A        +                 +                 +            |   8        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                A        M                 +                 M            |   6        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                +        +                 +                 +            |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                +        +                 +                 +            |   8        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                M        +                 A                 A            |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                A        M                 A                 A            |   2        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |          +     +        +        +                          +            |  11        |
      Lipoma                               |                                  X                                       |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                |                +        +                 +     +           +            |  12        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                +        +                 +                 +            |  12        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |                +        +                 +                 +            |  10        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                A        +                 +                 +            |   9        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                A        +                 +                 +            |   9        |
                                            __________________________________________________________________________|____________|
   Tongue                                  |                            +                                             |   1        |
      Squamous Cell Papilloma              |                            X                                             |          1 |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                +        +                 +                 +            |  10        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                +        +                 +                 +            |  12        |
                                            __________________________________________________________________________|____________|
   Heart                                   |                +        +                 +                 +            |  10        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Pheochromocytoma Benign              |                                                    X                     |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                +        +                 +                 +            |   9        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                +        +                 +                 +            |   9        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |    +  +     +  +  +     +     +     +  +  +     +  +     +  +  +  +  +  +|  35        |
      Pars Distalis, Adenoma               |    X           X              X           X        X                 X  X|         17 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                +     +  +                 +                 +            |  11        |
      C-Cell, Adenoma                      |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  25                                                               
NTP Experiment-Test: 05020-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:14:36  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 0| 2| 3| 3| 3| 2| 2| 2| 3| 3| 2| 2| 3| 9| 3| 2| 3| 3| 2| 3| 2| 3| 2| 3|            |
                                           | 1| 1| 9| 2| 0| 9| 9| 9| 6| 1| 1| 9| 9| 2| 4| 0| 9| 0| 1| 9| 2| 9| 1| 9| 2|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|     A      |
    6 MG/KG                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      C-Cell, Carcinoma                    |                      X                                                   |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |                +        +                 +                 +     +      |  11        |
      Adenoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Ovary                                   |          +     +        +              +  +           +     +            |  15        |
                                            __________________________________________________________________________|____________|
   Oviduct                                 |          +                             +  +                              |   8        |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +        +  +  +  +     +        +  +     +              +  +            |  20        |
      Polyp Stromal                        | X                                X                          X            |          7 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   | +     +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +     +  +     +|  37        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Femoral, Leukemia Mononuclear        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +              +  +     +                 +                 +            |  17        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                +  +     +                 +                 +            |  14        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +                                                                        |   1        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosarcoma                         |                                                                X         |          1 |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  |                +        +                 +                 +            |  11        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |       +        +        +                 +           +     +     +     +|  22        |
      Fibroadenoma                         |       X        X        X                 X                             X|         12 |
      Fibroadenoma, Multiple               |                                                       X                  |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    |       +        +        +                 +           +     +           +|  21        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                +        +                 +                 +            |  10        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                +        +                 +                 +            |  10        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                             +            |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  26                                                               
NTP Experiment-Test: 05020-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:14:36  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 0| 2| 3| 3| 3| 2| 2| 2| 3| 3| 2| 2| 3| 9| 3| 2| 3| 3| 2| 3| 2| 3| 2| 3|            |
                                           | 1| 1| 9| 2| 0| 9| 9| 9| 6| 1| 1| 9| 9| 2| 4| 0| 9| 0| 1| 9| 2| 9| 1| 9| 2|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|     A      |
    6 MG/KG                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |                +        +                 +                 +            |  11        |
                                            __________________________________________________________________________|____________|
   Nose                                    |                +        +                 +                 +            |  11        |
      Osteosarcoma                         |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Trachea                                 |                +        +                 +                 +     +      |  13        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |       +  +  +     +  +     +  +  +  +  +     +  +  +  +  +     +  +  +  +|  31        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                         +     +           +                 +     +      |  11        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Ureter                                  | +              +        +              +                 +  +           +|  11        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                A        +                 +                 +            |   8        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  27                                                               
NTP Experiment-Test: 05020-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:14:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 5| 7| 7| 6| 6| 6| 7| 6| 4| 7| 5| 4| 7| 6| 7| 6| 2| 7| 6| 7|             
                             DAY ON TEST   | 2| 1| 3| 3| 3| 2| 3| 2| 2| 3| 3| 2| 5| 5| 3| 6| 6| 3| 3| 3| 5| 6| 3| 6| 3|             
                                           | 9| 0| 1| 1| 0| 1| 1| 9| 6| 3| 3| 1| 5| 5| 2| 8| 6| 0| 9| 2| 5| 3| 0| 2| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Mesothelioma Malignant               |                                                       X                  |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma             |       X                                                                  |             
      Leukemia Mononuclear                 |          X                    X  X  X     X     X           X        X   |             
                                            __________________________________________________________________________|             
   Mesentery                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                     X                                X   |             
      Mesothelioma Malignant               |                                                       X                  |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                               X     X                                    |             
      Mesothelioma Malignant               |                                                       X                  |             
      Acinus, Adenoma                      |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                     X                                    |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                     X                                    |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                     X                                    |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                  +                    +                  |             
      Squamous Cell Papilloma              |                                  X                    X                  |             
                                            __________________________________________________________________________|             
   Tooth                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                               X     X                       X            |             
      Osteosarcoma, Metastatic, Bone       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Leukemia Mononuclear                 |                                     X                       X        X   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                     X                       X        X   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  28                                                               
NTP Experiment-Test: 05020-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:14:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 5| 7| 7| 6| 6| 6| 7| 6| 4| 7| 5| 4| 7| 6| 7| 6| 2| 7| 6| 7|             
                             DAY ON TEST   | 2| 1| 3| 3| 3| 2| 3| 2| 2| 3| 3| 2| 5| 5| 3| 6| 6| 3| 3| 3| 5| 6| 3| 6| 3|             
                                           | 9| 0| 1| 1| 0| 1| 1| 9| 6| 3| 3| 1| 5| 5| 2| 8| 6| 0| 9| 2| 5| 3| 0| 2| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pheochromocytoma Malignant           |                                                                          |             
      Pheochromocytoma Benign              | X                             X                             X        X  X|             
      Bilateral, Pheochromocytoma Benign   |       X                                   X                              |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |             X              X                                      X      |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                     X                                    |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Pars Distalis, Adenoma               |    X        X  X     X  X  X     X     X  X                       X      |             
      Pars Distalis, Adenoma, Multiple     |                                                                         X|             
      Pars Intermedia, Adenoma             |                            X                                             |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                               X     X                                    |             
      C-Cell, Adenoma                      | X     X     X     X                                                      |             
      C-Cell, Adenoma, Multiple            |                                                                         X|             
      C-Cell, Carcinoma                    |                         X                                                |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Mesothelioma Malignant               |                                                       X                  |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Leukemia Mononuclear                 |                                     X                                    |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                     X                                    |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  M     +  +  +  M  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelioma Malignant               |                                                       X                  |             
      Bilateral, Interstitial Cell, Adenoma| X     X  X  X     X  X  X                          X  X  X  X        X   |             
      Interstitial Cell, Adenoma           |                               X  X           X  X                       X|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   | +  +  +  +  +  +  +  +  +  +  +  +  +     +        +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X                    X  X  X                       X        X   |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femoral, Leukemia Mononuclear        |                               X     X           X                    X   |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Axillary, Leukemia Mononuclear       |                                     X                                    |             
      Deep Cervical, Leukemia Mononuclear  |                                     X                                    |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  29                                                               
NTP Experiment-Test: 05020-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:14:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 5| 7| 7| 6| 6| 6| 7| 6| 4| 7| 5| 4| 7| 6| 7| 6| 2| 7| 6| 7|             
                             DAY ON TEST   | 2| 1| 3| 3| 3| 2| 3| 2| 2| 3| 3| 2| 5| 5| 3| 6| 6| 3| 3| 3| 5| 6| 3| 6| 3|             
                                           | 9| 0| 1| 1| 0| 1| 1| 9| 6| 3| 3| 1| 5| 5| 2| 8| 6| 0| 9| 2| 5| 3| 0| 2| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Inguinal, Leukemia Mononuclear       |                                     X                                    |             
      Lumbar, Leukemia Mononuclear         |                                     X                                    |             
      Mediastinal, Leukemia Mononuclear    |                               X     X           X           X        X   |             
      Pancreatic, Leukemia Mononuclear     |                                                                          |             
      Renal, Leukemia Mononuclear          |                                     X                                    |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Leukemia Mononuclear                 |                               X     X           X           X            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +                    +              +           +                        |             
      Leukemia Mononuclear                 |                                     X           X                        |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X                    X  X  X     X     X           X        X   |             
      Mesothelioma Malignant               |                                                       X                  |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +|             
      Leukemia Mononuclear                 |                                     X           X                        |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  +  +  M  M  +  +  +  +  +  +  +  +  M  +  +  +  M  M  M  +  M  M  M  M|             
      Fibroadenoma                         |                         X                                                |             
                                            __________________________________________________________________________|             
   Skin                                    | M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basosquamous Tumor Benign            |                                                             X            |             
      Keratoacanthoma                      |                      X                                                   |             
      Leukemia Mononuclear                 |                                     X                                    |             
      Subcutaneous Tissue, Fibroma         |                                                                          |             
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Rib, Osteosarcoma                    |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         | M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                     X                                    |             
      Osteosarcoma, Metastatic, Bone       |                                                                          |             
      Diaphragm, Mesothelioma Malignant    |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Astrocytoma Benign                   | X                                                                        |             
      Ependymoma Malignant                 |                                                                          |             
      Leukemia Mononuclear                 |                                     X                                    |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                        +                                 |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  30                                                               
NTP Experiment-Test: 05020-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:14:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 5| 7| 7| 6| 6| 6| 7| 6| 4| 7| 5| 4| 7| 6| 7| 6| 2| 7| 6| 7|             
                             DAY ON TEST   | 2| 1| 3| 3| 3| 2| 3| 2| 2| 3| 3| 2| 5| 5| 3| 6| 6| 3| 3| 3| 5| 6| 3| 6| 3|             
                                           | 9| 0| 1| 1| 0| 1| 1| 9| 6| 3| 3| 1| 5| 5| 2| 8| 6| 0| 9| 2| 5| 3| 0| 2| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Leukemia Mononuclear                 |          X                    X     X     X     X           X        X   |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                     X                                    |             
      Polyp                                |                                                                         X|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |       +                             +                                    |             
      Bilateral, Leukemia Mononuclear      |                                     X                                    |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                               X     X     X     X           X        X   |             
      Mesothelioma Malignant               |                                                       X                  |             
                                            __________________________________________________________________________|             
   Ureter                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Leukemia Mononuclear                 |                                     X                                    |             
                                            __________________________________________________________________________|             
   Urethra                                 | +  +  +  +  +  +  +  +     +        +     +           +  +  +  +         |             
      Leukemia Mononuclear                 |                                     X                                    |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                     X                                    |             
      Mesothelioma Malignant               |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X                    X  X  X     X     X           X        X   |             
      Mesothelioma Malignant               |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  31                                                               
NTP Experiment-Test: 05020-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:14:36  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 5| 7| 6| 6| 3| 0| 7| 5| 7| 6| 7| 6| 7| 6| 5| 7| 6| 5| 7|  |            |
                             DAY ON TEST   | 3| 2| 3| 2| 3| 7| 3| 8| 2| 3| 7| 0| 5| 3| 7| 0| 8| 3| 4| 1| 0| 8| 8| 2|  |            |
                                           | 2| 9| 0| 8| 1| 8| 2| 8| 7| 0| 2| 9| 4| 1| 4| 1| 8| 0| 7| 2| 4| 0| 4| 3|  |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|  |     A      |
    VEHICLE                                | 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|  |     L      |
                                           | 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|  |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +   |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  A  +  M  +  +  +  +  +  +  +  +  +  +  +   |  46        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  M  +  +  +  +   |  46        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +   |  47        |
      Mesothelioma Malignant               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +   |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +   |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  M  +  +  +   |  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +   |  46        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Hepatocellular Carcinoma             |                                                                          |          1 |
      Leukemia Mononuclear                 |    X  X              X           X  X     X  X  X  X  X        X  X  X   |         21 |
                                            __________________________________________________________________________|____________|
   Mesentery                               | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +   |  47        |
      Leukemia Mononuclear                 |       X              X           X        X        X  X                  |          8 |
      Mesothelioma Malignant               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +   |  48        |
      Leukemia Mononuclear                 |       X                                   X                              |          4 |
      Mesothelioma Malignant               |                                                                          |          1 |
      Acinus, Adenoma                      |                                                    X                     |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +   |  48        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  M  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +   |  47        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +   |  48        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   2        |
      Squamous Cell Papilloma              |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Tooth                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Leukemia Mononuclear                 |                                                                          |          3 |
      Osteosarcoma, Metastatic, Bone       |          X                                                               |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  32                                                               
NTP Experiment-Test: 05020-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:14:36  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 5| 7| 6| 6| 3| 0| 7| 5| 7| 6| 7| 6| 7| 6| 5| 7| 6| 5| 7|  |            |
                             DAY ON TEST   | 3| 2| 3| 2| 3| 7| 3| 8| 2| 3| 7| 0| 5| 3| 7| 0| 8| 3| 4| 1| 0| 8| 8| 2|  |            |
                                           | 2| 9| 0| 8| 1| 8| 2| 8| 7| 0| 2| 9| 4| 1| 4| 1| 8| 0| 7| 2| 4| 0| 4| 3|  |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|  |     A      |
    VEHICLE                                | 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|  |     L      |
                                           | 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|  |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Adenoma                              |                      X                                                   |          1 |
      Leukemia Mononuclear                 |                      X           X  X     X  X  X  X  X        X  X  X   |         14 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Leukemia Mononuclear                 |                      X           X  X     X  X  X  X  X        X  X  X   |         14 |
      Pheochromocytoma Malignant           |                                                             X            |          1 |
      Pheochromocytoma Benign              |    X  X                                X     X              X            |         10 |
      Bilateral, Pheochromocytoma Benign   | X                                                                        |          3 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +   |  48        |
      Adenoma                              |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  48        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  47        |
      Leukemia Mononuclear                 |                                                                   X      |          1 |
      Pars Distalis, Adenoma               | X        X  X                    X        X           X  X     X     X   |         19 |
      Pars Distalis, Adenoma, Multiple     |                                                                          |          1 |
      Pars Intermedia, Adenoma             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +   |  48        |
      Leukemia Mononuclear                 |                                                                          |          2 |
      C-Cell, Adenoma                      |                   X                 X  X                             X   |          8 |
      C-Cell, Adenoma, Multiple            |                                                                          |          1 |
      C-Cell, Carcinoma                    |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Leukemia Mononuclear                 |                                                                   X      |          1 |
      Mesothelioma Malignant               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  46        |
      Adenoma                              |       X                                                                  |          1 |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +     +  +  +  +  +  +              +  +     +     +        +  +   |  36        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Mesothelioma Malignant               |                                                                          |          1 |
      Bilateral, Interstitial Cell, Adenoma| X  X  X     X     X  X           X     X  X     X  X        X  X         |         25 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  33                                                               
NTP Experiment-Test: 05020-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:14:36  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 5| 7| 6| 6| 3| 0| 7| 5| 7| 6| 7| 6| 7| 6| 5| 7| 6| 5| 7|  |            |
                             DAY ON TEST   | 3| 2| 3| 2| 3| 7| 3| 8| 2| 3| 7| 0| 5| 3| 7| 0| 8| 3| 4| 1| 0| 8| 8| 2|  |            |
                                           | 2| 9| 0| 8| 1| 8| 2| 8| 7| 0| 2| 9| 4| 1| 4| 1| 8| 0| 7| 2| 4| 0| 4| 3|  |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|  |     A      |
    VEHICLE                                | 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|  |     L      |
                                           | 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|  |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Interstitial Cell, Adenoma           |          X              X           X                 X           X  X   |         11 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   | +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +   |  44        |
      Leukemia Mononuclear                 |    X  X              X           X  X     X  X  X  X  X        X  X  X   |         19 |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Femoral, Leukemia Mononuclear        |                      X                       X                           |          6 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Axillary, Leukemia Mononuclear       |                                                                          |          1 |
      Deep Cervical, Leukemia Mononuclear  |                                                                          |          1 |
      Inguinal, Leukemia Mononuclear       |       X                          X  X                                    |          4 |
      Lumbar, Leukemia Mononuclear         |                                                                          |          1 |
      Mediastinal, Leukemia Mononuclear    |    X  X              X           X  X        X  X     X        X  X  X   |         16 |
      Pancreatic, Leukemia Mononuclear     |                                                       X                  |          1 |
      Renal, Leukemia Mononuclear          |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  48        |
      Leukemia Mononuclear                 |    X  X              X           X  X     X  X  X  X  X        X  X  X   |         17 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |             +        +           +           +     +                 +   |  10        |
      Leukemia Mononuclear                 |                      X           X           X     X                 X   |          7 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Leukemia Mononuclear                 |    X  X              X           X  X     X  X  X  X  X        X  X  X   |         21 |
      Mesothelioma Malignant               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +   |  43        |
      Leukemia Mononuclear                 |                      X           X  X        X                    X  X   |          8 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  M  +  +  +  +  +  +  M  M  M  +  +  +  +  M  +  +  +  +  +  +  +  M   |  32        |
      Fibroadenoma                         |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  47        |
      Basosquamous Tumor Benign            |                                                                          |          1 |
      Keratoacanthoma                      |                                  X                                       |          2 |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Subcutaneous Tissue, Fibroma         |       X                          X                             X         |          3 |
      Subcutaneous Tissue, Fibrosarcoma    |                   X                                                      |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  48        |
      Rib, Osteosarcoma                    |          X                                                               |          1 |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  47        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  34                                                               
NTP Experiment-Test: 05020-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:14:36  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 5| 7| 6| 6| 3| 0| 7| 5| 7| 6| 7| 6| 7| 6| 5| 7| 6| 5| 7|  |            |
                             DAY ON TEST   | 3| 2| 3| 2| 3| 7| 3| 8| 2| 3| 7| 0| 5| 3| 7| 0| 8| 3| 4| 1| 0| 8| 8| 2|  |            |
                                           | 2| 9| 0| 8| 1| 8| 2| 8| 7| 0| 2| 9| 4| 1| 4| 1| 8| 0| 7| 2| 4| 0| 4| 3|  |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|  |     A      |
    VEHICLE                                | 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|  |     L      |
                                           | 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|  |            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Osteosarcoma, Metastatic, Bone       |          X                                                               |          1 |
      Diaphragm, Mesothelioma Malignant    |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Astrocytoma Benign                   |                                                                          |          1 |
      Ependymoma Malignant                 |                            X                                             |          1 |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                +                                                         |   1        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                +           +                                   +         |   4        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Alveolar/Bronchiolar Adenoma         |             X                                                            |          1 |
      Leukemia Mononuclear                 |    X  X              X           X  X     X  X  X  X  X        X  X  X   |         20 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +   |  48        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Polyp                                |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |       +           +  +                                            +  +   |   7        |
      Bilateral, Leukemia Mononuclear      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M   |  46        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +   |  48        |
      Leukemia Mononuclear                 |    X                 X           X  X     X  X  X  X  X        X  X  X   |         18 |
      Mesothelioma Malignant               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Ureter                                  | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  47        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urethra                                 |                                  +     +  +  +        +     +            |  21        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  M  +  +  +  +   |  47        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Mesothelioma Malignant               |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  35                                                               
NTP Experiment-Test: 05020-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:14:36  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 5| 7| 6| 6| 3| 0| 7| 5| 7| 6| 7| 6| 7| 6| 5| 7| 6| 5| 7|  |            |
                             DAY ON TEST   | 3| 2| 3| 2| 3| 7| 3| 8| 2| 3| 7| 0| 5| 3| 7| 0| 8| 3| 4| 1| 0| 8| 8| 2|  |            |
                                           | 2| 9| 0| 8| 1| 8| 2| 8| 7| 0| 2| 9| 4| 1| 4| 1| 8| 0| 7| 2| 4| 0| 4| 3|  |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|  |     A      |
    VEHICLE                                | 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|  |     L      |
                                           | 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|  |            |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Leukemia Mononuclear                 |    X  X              X           X  X     X  X  X  X  X        X  X  X   |         21 |
      Mesothelioma Malignant               |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  36                                                               
NTP Experiment-Test: 05020-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:14:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 6| 6| 4| 7| 7| 6| 5| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 1| 3| 1| 2| 3| 5| 9| 8| 3| 3| 8| 5| 3| 3| 2| 3| 7| 3| 5| 3| 3| 3| 3|             
                                           | 2| 0| 6| 2| 5| 9| 2| 1| 3| 6| 0| 1| 7| 6| 2| 1| 9| 1| 3| 2| 1| 0| 2| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    2 MG/KG                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |                            +           +                                 |             
                                            __________________________________________________________________________|             
   Intestine Large                         |                +           +           +                                 |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |                            +           +                                 |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                            +           +                                 |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |                            +           +                                 |             
                                            __________________________________________________________________________|             
   Intestine Small                         |                            +           +                    +            |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |                            +           +                                 |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |                            +           +                                 |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                            +           +                    +            |             
      Adenocarcinoma                       |                                                             X            |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma             |                                                                          |             
      Leukemia Mononuclear                 |                X                                                         |             
      Mesothelioma Malignant               |                                                                          |             
      Neoplastic Nodule                    |    X                                      X        X                     |             
                                            __________________________________________________________________________|             
   Mesentery                               |                            +           +                 +  +  +         |             
      Mesothelioma Malignant               |                                                                          |             
      Sarcoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |                            M           +                                 |             
      Leukemia Mononuclear                 |                                                                          |             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |                            +           +                                 |             
                                            __________________________________________________________________________|             
   Stomach                                 |                            +           +                                 |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |                            +           +                                 |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |                            +           +                                 |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                   +      |             
      Squamous Cell Papilloma              |                                                                   X      |             
                                            __________________________________________________________________________|             
   Tooth                                   |                            +           +                                 |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +     +                    +           +     +                           |             
                                            __________________________________________________________________________|             
   Heart                                   |    +  +     +           +  +  +        +                             +   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Osteosarcoma, Metastatic, Bone       |                                                                          |             
      Pheochromocytoma Benign              |    X              X  X  X     X           X  X                           |             
      Bilateral, Pheochromocytoma Benign   |                                                          X               |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |                            M           +                                 |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |       +        +           +           +                                 |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  37                                                               
NTP Experiment-Test: 05020-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:14:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 6| 6| 4| 7| 7| 6| 5| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 1| 3| 1| 2| 3| 5| 9| 8| 3| 3| 8| 5| 3| 3| 2| 3| 7| 3| 5| 3| 3| 3| 3|             
                                           | 2| 0| 6| 2| 5| 9| 2| 1| 3| 6| 0| 1| 7| 6| 2| 1| 9| 1| 3| 2| 1| 0| 2| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    2 MG/KG                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +        +              +           +                 +     +        +|             
      Pars Distalis, Adenoma               |    X        X              X                             X     X         |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |       A        +           +           +  +                              |             
      C-Cell, Adenoma                      |                X                          X                              |             
      C-Cell, Carcinoma                    |                                                                          |             
      Follicular Cell, Adenocarcinoma      |                            X                                             |             
      Follicular Cell, Adenoma             |                                           X                              |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +           +  +     +  +           +           +        +  +  +      |             
      Mesothelioma Malignant               |                                                                          |             
      Bilateral, Mesothelioma Malignant    |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |             +        +     +     +  +  +              +                  |             
      Adenoma                              |                      X           X  X                 X                  |             
                                            __________________________________________________________________________|             
   Prostate                                |                            +           +                                 |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                                        +                                 |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Mesothelioma Malignant               |                                                                          |             
      Bilateral, Mesothelioma Malignant    |                                                                          |             
      Bilateral, Interstitial Cell, Adenoma| X  X  X  X     X  X     X     X     X     X  X  X  X  X  X  X  X  X     X|             
      Interstitial Cell, Adenoma           |                      X           X     X                                 |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   | +  +     +     +  +     +  +  +  +     +  +  +  +  +  +  +     +  +  +  +|             
      Leukemia Mononuclear                 |                X                                                         |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +              +        +  +        +  +     +           +  +            |             
      Pancreatic, Leukemia Mononuclear     |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |                +        +              +                                 |             
      Leukemia Mononuclear                 |                X                                                         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                            +           +                 +  +            |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosarcoma                         |                                     X                                    |             
      Leukemia Mononuclear                 |                X                                                         |             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +                          +           +     +                           |             
      Thymoma Benign                       |                                              X                           |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  38                                                               
NTP Experiment-Test: 05020-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:14:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 6| 6| 4| 7| 7| 6| 5| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 1| 3| 1| 2| 3| 5| 9| 8| 3| 3| 8| 5| 3| 3| 2| 3| 7| 3| 5| 3| 3| 3| 3|             
                                           | 2| 0| 6| 2| 5| 9| 2| 1| 3| 6| 0| 1| 7| 6| 2| 1| 9| 1| 3| 2| 1| 0| 2| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    2 MG/KG                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +           +              +     +     +                                 |             
      Fibroadenoma                         | X                                X                                       |             
                                            __________________________________________________________________________|             
   Skin                                    | +           +           +  +     +  +  +        +     +                  |             
      Basal Cell Adenoma                   |                                                                          |             
      Basosquamous Tumor Benign            |                                                 X                        |             
      Keratoacanthoma                      |                                                                          |             
      Squamous Cell Carcinoma              |                         X                                                |             
      Subcutaneous Tissue, Fibroma         |                                                                          |             
      Subcutaneous Tissue, Fibrosarcoma    |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cranium, Osteosarcoma                |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                            +           +                                 |             
      Osteosarcoma, Metastatic, Bone       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |                            +           +                                 |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                            +                                             |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |                            +           +                    +            |             
      Osteosarcoma, Metastatic, Bone       |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |                            +           +                                 |             
                                            __________________________________________________________________________|             
   Trachea                                 |                            +           +                                 |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     | +  +        +                 +                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                            +                                             |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X                                                         |             
      Osteosarcoma, Metastatic, Bone       |                                                                          |             
                                            __________________________________________________________________________|             
   Ureter                                  | +  +           +  +        +  +        +  +  +     +     +  +  +         |             
                                            __________________________________________________________________________|             
   Urethra                                 |                            +                                             |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |                            +           +                 +               |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X                                                         |             
      Mesothelioma Malignant               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  39                                                               
NTP Experiment-Test: 05020-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:14:36  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 6| 5| 7| 7| 6| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 2| 2| 2| 5| 2| 3| 3| 5| 2| 3| 5| 2| 3| 3| 3| 5| 2| 3| 3| 3| 7| 3| 1| 3|            |
                                           | 1| 9| 9| 6| 4| 9| 1| 1| 4| 9| 2| 1| 7| 0| 0| 1| 4| 9| 2| 0| 2| 4| 1| 4| 0|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|     A      |
    2 MG/KG                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |          +     +                    +                                    |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |          +     +                    +                 +                  |   7        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |          +     +                    +                                    |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |          +     +                    +                                    |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |          +     +                    +                                    |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |          +     +                    +                                    |   6        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |          +     +                    +                                    |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |          +     +                    +                                    |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |          +     +                    +                                    |   6        |
      Adenocarcinoma                       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hepatocellular Carcinoma             |                                              X                           |          1 |
      Leukemia Mononuclear                 |                                              X                 X         |          3 |
      Mesothelioma Malignant               |                                                                      X   |          1 |
      Neoplastic Nodule                    |    X                 X                                                   |          5 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |          +     +                 +  +                                +  +|  11        |
      Mesothelioma Malignant               |                                  X                                   X   |          2 |
      Sarcoma                              |                                                                         X|          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +        +     +                 +  +                          +     +   |   8        |
      Leukemia Mononuclear                 |                                                                X         |          1 |
      Mesothelioma Malignant               |                                  X                                   X   |          2 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |          +     +                 +  +                                    |   6        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |          +     +                    +           +                        |   6        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |          +     +                    +           +                        |   6        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |          +     +                    +           +                        |   6        |
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
      Squamous Cell Papilloma              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Tooth                                   |          +     +                    +                                    |   5        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |          +     +                    +                                    |   8        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +     +     +     +           +  +                 +  +           +   |  18        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                                X         |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |                                                                X         |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  40                                                               
NTP Experiment-Test: 05020-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:14:36  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 6| 5| 7| 7| 6| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 2| 2| 2| 5| 2| 3| 3| 5| 2| 3| 5| 2| 3| 3| 3| 5| 2| 3| 3| 3| 7| 3| 1| 3|            |
                                           | 1| 9| 9| 6| 4| 9| 1| 1| 4| 9| 2| 1| 7| 0| 0| 1| 4| 9| 2| 0| 2| 4| 1| 4| 0|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|     A      |
    2 MG/KG                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Osteosarcoma, Metastatic, Bone       |                X                                                         |          1 |
      Pheochromocytoma Benign              |                   X        X                       X        X  X         |         12 |
      Bilateral, Pheochromocytoma Benign   |                                                       X                  |          2 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |          +     +                    +                                    |   4        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |          +     +                    +                                    |   7        |
      Adenoma                              |                X                                                         |          1 |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +     +  +  +  +           +        M     +     +        +        +  +   |  18        |
      Pars Distalis, Adenoma               | X     X     X              X                    X        X        X  X   |         13 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |          +     +                    +                       +            |   8        |
      C-Cell, Adenoma                      |                                                                          |          2 |
      C-Cell, Carcinoma                    |                                                             X            |          1 |
      Follicular Cell, Adenocarcinoma      |                                                                          |          1 |
      Follicular Cell, Adenoma             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |    +     +     +  +                 +     +                       +  +  +|  20        |
      Mesothelioma Malignant               |                                                                      X   |          1 |
      Bilateral, Mesothelioma Malignant    |                                                                         X|          1 |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |          +     +        +           +                 +                  |  12        |
      Adenoma                              |          X              X                             X                  |          7 |
                                            __________________________________________________________________________|____________|
   Prostate                                |          +     +                    +                                +   |   6        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                                     +                                +   |   3        |
                                            __________________________________________________________________________|____________|
   Testes                                  |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|  46        |
      Mesothelioma Malignant               |                                  X                                   X   |          2 |
      Bilateral, Mesothelioma Malignant    |                                                                         X|          1 |
      Bilateral, Interstitial Cell, Adenoma|    X  X           X  X  X  X  X  X  X  X  X  X     X  X     X  X  X  X  X|         38 |
      Interstitial Cell, Adenoma           |          X  X                                            X               |          6 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
      Leukemia Mononuclear                 |                                              X                 X         |          3 |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |          +     +                 +  +  +     +                 +         |  16        |
      Pancreatic, Leukemia Mononuclear     |                                                                X         |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |          +     +                 +  +                                    |   7        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  41                                                               
NTP Experiment-Test: 05020-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:14:36  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 6| 5| 7| 7| 6| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 2| 2| 2| 5| 2| 3| 3| 5| 2| 3| 5| 2| 3| 3| 3| 5| 2| 3| 3| 3| 7| 3| 1| 3|            |
                                           | 1| 9| 9| 6| 4| 9| 1| 1| 4| 9| 2| 1| 7| 0| 0| 1| 4| 9| 2| 0| 2| 4| 1| 4| 0|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|     A      |
    2 MG/KG                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                                              +                           |   5        |
      Leukemia Mononuclear                 |                                              X                           |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosarcoma                         |                                                                          |          1 |
      Leukemia Mononuclear                 |                                              X                 X         |          3 |
      Mesothelioma Malignant               |                                  X                                   X   |          2 |
                                            __________________________________________________________________________|____________|
   Thymus                                  |          M     M                    +                                    |   5        |
      Thymoma Benign                       |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |          M     +                    M                                    |   6        |
      Fibroadenoma                         |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Skin                                    |          +     +  +     +  +        +  +              +              +   |  18        |
      Basal Cell Adenoma                   |                            X                                             |          1 |
      Basosquamous Tumor Benign            |                                                                          |          1 |
      Keratoacanthoma                      |                                        X                                 |          1 |
      Squamous Cell Carcinoma              |                                                                          |          1 |
      Subcutaneous Tissue, Fibroma         |          X        X                                                      |          2 |
      Subcutaneous Tissue, Fibrosarcoma    |                         X                                                |          2 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cranium, Osteosarcoma                |                X                                                         |          1 |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |          +     +                    +                                +   |   6        |
      Osteosarcoma, Metastatic, Bone       |                X                                                         |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |          +     +                    +                                    |   5        |
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |          +     +                 +  +                                    |   7        |
      Osteosarcoma, Metastatic, Bone       |                X                                                         |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    |          +     +                    +                                    |   5        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |          +     +                    +                                    |   5        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     | +     +              +           +     +  +           +                  |  11        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |          +           +                                   +               |   4        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  42                                                               
NTP Experiment-Test: 05020-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:14:36  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 6| 5| 7| 7| 6| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 2| 2| 2| 5| 2| 3| 3| 5| 2| 3| 5| 2| 3| 3| 3| 5| 2| 3| 3| 3| 7| 3| 1| 3|            |
                                           | 1| 9| 9| 6| 4| 9| 1| 1| 4| 9| 2| 1| 7| 0| 0| 1| 4| 9| 2| 0| 2| 4| 1| 4| 0|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|     A      |
    2 MG/KG                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                                X         |          2 |
      Osteosarcoma, Metastatic, Bone       |                X                                                         |          1 |
                                            __________________________________________________________________________|____________|
   Ureter                                  | +     +  +     +                    +           +  +  +  +  +        +   |  24        |
                                            __________________________________________________________________________|____________|
   Urethra                                 |                +                                                     +   |   3        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |          +     +                    +                                +   |   7        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                              X                 X         |          3 |
      Mesothelioma Malignant               |                                  X                                   X  X|          3 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  43                                                               
NTP Experiment-Test: 05020-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:14:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 4| 6| 7| 7| 6| 7| 6| 6| 7| 7| 6| 7| 5| 7| 7| 5| 6| 6| 5| 5| 6|             
                             DAY ON TEST   | 2| 5| 3| 3| 7| 8| 1| 3| 2| 3| 7| 7| 2| 2| 1| 0| 2| 3| 3| 3| 2| 8| 8| 5| 8|             
                                           | 2| 4| 0| 2| 6| 6| 2| 0| 2| 1| 4| 6| 8| 8| 8| 0| 2| 0| 0| 5| 4| 6| 4| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    18 MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  A  +  +  +  A  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  A  +  +  +  A  +  +  +  +  +  A  A  +  +  +  +  A  +  +  +  +|             
      Colon, Rectum, Osteosarcoma,         |                                                                          |             
          Metastatic, Spleen               |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  A  +  +  +  A  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  A  +  +  +  A  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  M  +  +|             
      Fibrosarcoma, Metastatic, Spleen     |                                                                X         |             
      Osteosarcoma, Metastatic, Spleen     |                                     X                 X                  |             
      Ileum, Jejunum, Osteosarcoma,        |                                                                          |             
          Metastatic, Spleen               |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  M  +  +  A  +  +  +  A  +  +  A  +  +  A  A  +  +  A  +  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  A  +  +  A  +  +  +  A  +  +  A  +  +  A  A  +  +  A  +  +  +  +  +  +|             
      Osteosarcoma, Metastatic, Spleen     |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Fibrosarcoma, Metastatic, Spleen     |                X                                               X     X   |             
      Leukemia Mononuclear                 |                                                                         X|             
      Osteosarcoma, Metastatic, Spleen     | X     X                       X     X                 X           X      |             
                                            __________________________________________________________________________|             
   Mesentery                               | +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosarcoma, Metastatic, Spleen     |    X           X                       X        X              X     X   |             
      Leukemia Mononuclear                 |                                                                         X|             
      Mesothelioma Malignant               |                                                             X            |             
      Osteosarcoma, Metastatic, Spleen     | X                             X     X        X        X           X      |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Fibrosarcoma, Metastatic, Spleen     |    X           X                                X              X         |             
      Mesothelioma Malignant               |                                                                          |             
      Osteosarcoma, Metastatic, Spleen     | X     X                       X     X        X        X                  |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  A  +  +  +  A  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  A  +  +  +  A  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +|             
      Osteosarcoma, Metastatic, Spleen     |                                                       X                  |             
      Glandular, Osteosarcoma, Metastatic, |                                                                          |             
           Spleen                          |                                     X                                    |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  A  +  +  +  A  +  +  +     +  A  A  +  +  +  +  +  +  +  +  +|             
      Fibrosarcoma, Metastatic, Spleen     |                                                                          |             
      Osteosarcoma, Metastatic, Spleen     |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
      Squamous Cell Papilloma              |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Gingiva, Squamous Cell Carcinoma     | X                                                                        |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  44                                                               
NTP Experiment-Test: 05020-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:14:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 4| 6| 7| 7| 6| 7| 6| 6| 7| 7| 6| 7| 5| 7| 7| 5| 6| 6| 5| 5| 6|             
                             DAY ON TEST   | 2| 5| 3| 3| 7| 8| 1| 3| 2| 3| 7| 7| 2| 2| 1| 0| 2| 3| 3| 3| 2| 8| 8| 5| 8|             
                                           | 2| 4| 0| 2| 6| 6| 2| 0| 2| 1| 4| 6| 8| 8| 8| 0| 2| 0| 0| 5| 4| 6| 4| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    18 MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pulmonary Artery, Fibrosarcoma,      |                                                                          |             
          Metastatic, Spleen               |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Capsule, Fibrosarcoma, Metastatic,   |                                                                          |             
           Spleen                          |                                                                          |             
      Capsule, Osteosarcoma, Metastatic,   |                                                                          |             
           Spleen                          |                                                                          |             
      Medulla, Fibrosarcoma, Metastatic,   |                                                                          |             
           Spleen                          |    X                                                                     |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +     +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Pheochromocytoma Malignant           |                                                    X                     |             
      Pheochromocytoma Benign              |       X              X     X              X                              |             
      Bilateral, Pheochromocytoma Benign   |          X              X        X     X                                 |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | M  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Adenoma                              |                   X                                                      |             
      Carcinoma                            |                                                                          |             
      Fibrosarcoma, Metastatic, Spleen     |    X                                                           X         |             
      Osteosarcoma, Metastatic, Spleen     |                               X     X        X        X                  |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                     X                                    |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  M|             
      Pars Distalis, Adenoma               |    X     X        X                    X     X                           |             
      Pars Distalis, Adenoma, Multiple     |                                                    X                     |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      |          X        X                 X                          X         |             
      C-Cell, Carcinoma                    |                                                                X         |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                   +      |             
      Osteosarcoma, Metastatic, Spleen     |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosarcoma, Metastatic, Spleen     |                                                                          |             
      Osteosarcoma, Metastatic, Spleen     |                                              X                           |             
      Sarcoma                              |                                                                          |             
      Bilateral, Mesothelioma Malignant    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  45                                                               
NTP Experiment-Test: 05020-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:14:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 4| 6| 7| 7| 6| 7| 6| 6| 7| 7| 6| 7| 5| 7| 7| 5| 6| 6| 5| 5| 6|             
                             DAY ON TEST   | 2| 5| 3| 3| 7| 8| 1| 3| 2| 3| 7| 7| 2| 2| 1| 0| 2| 3| 3| 3| 2| 8| 8| 5| 8|             
                                           | 2| 4| 0| 2| 6| 6| 2| 0| 2| 1| 4| 6| 8| 8| 8| 0| 2| 0| 0| 5| 4| 6| 4| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    18 MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Bilateral, Osteosarcoma, Metastatic, |                                                                          |             
           Spleen                          |                                                                   X      |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma                       |                                                          X               |             
      Adenoma                              |                                                    X                     |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosarcoma, Metastatic, Spleen     |                                                 X                        |             
      Osteosarcoma, Metastatic, Spleen     |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |             +     +     +           M     +  +  +        +  +        +  +|             
      Osteosarcoma, Metastatic, Spleen     |                                              X                           |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelioma Malignant               |                                                             X            |             
      Osteosarcoma, Metastatic, Spleen     |                                     X                 X           X      |             
      Bilateral, Interstitial Cell, Adenoma| X  X  X  X     X     X  X  X     X  X     X  X     X  X        X  X     X|             
      Interstitial Cell, Adenoma           |                               X        X                 X  X        X   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |       +  +     +  +  +     +        +  +           +     +           +  +|             
      Leukemia Mononuclear                 |                                                                         X|             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Osteosarcoma, Metastatic, Spleen     |                                                                   X      |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +|             
      Mediastinal, Fibrosarcoma,           |                                                                          |             
          Metastatic, Spleen               |                X                                               X         |             
      Mediastinal, Leukemia Mononuclear    |                                                                         X|             
      Mediastinal, Osteosarcoma,           |                                                                          |             
          Metastatic, Spleen               | X                             X     X                 X                  |             
      Mediastinal, Pancreatic,             |                                                                          |             
          Fibrosarcoma, Metastatic, Spleen |                                                                          |             
      Pancreatic, Mesothelioma Malignant   |                                                                          |             
      Renal, Leukemia Mononuclear          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                         X|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +                          M                                      +  +|             
      Leukemia Mononuclear                 |                                                                         X|             
      Mediastinal, Osteosarcoma,           |                                                                          |             
          Metastatic, Spleen               |                                                                          |             
      Pancreatic, Fibrosarcoma, Metastatic,|                                                                          |             
           Spleen                          |    X                                                                     |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibroma                              |                                                                         X|             
      Fibrosarcoma                         |    X           X     X                 X  X     X  X        X  X     X   |             
      Hemangiosarcoma                      |                   X     X              X  X                              |             
      Leukemia Mononuclear                 |                                                                         X|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  46                                                               
NTP Experiment-Test: 05020-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:14:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 4| 6| 7| 7| 6| 7| 6| 6| 7| 7| 6| 7| 5| 7| 7| 5| 6| 6| 5| 5| 6|             
                             DAY ON TEST   | 2| 5| 3| 3| 7| 8| 1| 3| 2| 3| 7| 7| 2| 2| 1| 0| 2| 3| 3| 3| 2| 8| 8| 5| 8|             
                                           | 2| 4| 0| 2| 6| 6| 2| 0| 2| 1| 4| 6| 8| 8| 8| 0| 2| 0| 0| 5| 4| 6| 4| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    18 MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Mesothelioma Malignant               |                                                                          |             
      Osteosarcoma                         | X     X  X                 X  X  X  X        X        X           X      |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  A  +  +  +  +  +  M  M  M  M  +  A  M  +  +  +  +  +  +  +  M|             
      Leukemia Mononuclear                 |                                                                          |             
      Osteosarcoma, Metastatic, Spleen     |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  M  +  +  M  M  +|             
      Fibroadenoma                         |                                                    X                    X|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Keratoacanthoma                      | X                                                                        |             
      Subcutaneous Tissue, Fibroma         |                                  X                 X                     |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Osteosarcoma, Metastatic, Spleen     |                               X              X                           |             
      Diaphragm, Fibrosarcoma, Metastatic, |                                                                          |             
           Spleen                          |    X           X                                                         |             
      Diaphragm, Osteosarcoma, Metastatic, |                                                                          |             
           Spleen                          |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosarcoma, Metastatic, Spleen     |    X           X                                X              X         |             
      Hemangiosarcoma, Metastatic, Spleen  |                         X                                                |             
      Leukemia Mononuclear                 |                                                                         X|             
      Osteosarcoma, Metastatic, Spleen     | X                                                     X           X      |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  M|             
      Nasolacrimal Duct, Squamous Cell     |                                                                          |             
          Carcinoma                        |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     | +                                                                        |             
                                            __________________________________________________________________________|             
   Eye                                     | +     +  +        +  +     +                             +               |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  A  M  +  +  +  +  +  +  +  M|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  47                                                               
NTP Experiment-Test: 05020-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:14:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 4| 6| 7| 7| 6| 7| 6| 6| 7| 7| 6| 7| 5| 7| 7| 5| 6| 6| 5| 5| 6|             
                             DAY ON TEST   | 2| 5| 3| 3| 7| 8| 1| 3| 2| 3| 7| 7| 2| 2| 1| 0| 2| 3| 3| 3| 2| 8| 8| 5| 8|             
                                           | 2| 4| 0| 2| 6| 6| 2| 0| 2| 1| 4| 6| 8| 8| 8| 0| 2| 0| 0| 5| 4| 6| 4| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    18 MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosarcoma, Metastatic, Spleen     |    X                                                           X         |             
      Leukemia Mononuclear                 |                                                                         X|             
      Osteosarcoma, Metastatic, Spleen     |                               X     X                 X                  |             
      Renal Tubule, Adenoma                |       X                                                                  |             
                                            __________________________________________________________________________|             
   Ureter                                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Urethra                                 |                   +  +        +        +              +           +      |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  A  +  +  +  +  +  +  +  +  +|             
      Fibrosarcoma, Metastatic, Spleen     |                                                 X                        |             
      Osteosarcoma, Metastatic, Spleen     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                         X|             
      Mesothelioma Malignant               |                                                             X            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  48                                                               
NTP Experiment-Test: 05020-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:14:36  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 4| 6|            |
                             DAY ON TEST   | 3| 3| 3| 5| 2| 3| 3| 2| 3| 3| 7| 2| 1| 2| 3| 5| 2| 2| 3| 3| 9| 1| 3| 1| 8|            |
                                           | 0| 1| 1| 9| 9| 0| 2| 9| 1| 2| 9| 1| 5| 9| 1| 9| 9| 8| 1| 2| 4| 6| 0| 5| 9|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|     A      |
    18 MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  44        |
      Colon, Rectum, Osteosarcoma,         |                                                                          |            |
          Metastatic, Spleen               |                                                             X            |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +     +  +  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Fibrosarcoma, Metastatic, Spleen     |                                                                X         |          2 |
      Osteosarcoma, Metastatic, Spleen     |                                                       X                  |          3 |
      Ileum, Jejunum, Osteosarcoma,        |                                                                          |            |
          Metastatic, Spleen               |                                                             X            |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +     +  +  +  A|  39        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +     +  +  +  +|  41        |
      Osteosarcoma, Metastatic, Spleen     |                      X                                                   |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Fibrosarcoma, Metastatic, Spleen     |                                                                X         |          4 |
      Leukemia Mononuclear                 |                                     X           X                        |          3 |
      Osteosarcoma, Metastatic, Spleen     |                         X                             X                  |          8 |
                                            __________________________________________________________________________|____________|
   Mesentery                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Fibrosarcoma, Metastatic, Spleen     |                                              X     X           X         |          9 |
      Leukemia Mononuclear                 |                                     X                                    |          2 |
      Mesothelioma Malignant               |                                           X                              |          2 |
      Osteosarcoma, Metastatic, Spleen     |       X  X           X                                X     X            |         11 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Fibrosarcoma, Metastatic, Spleen     |                                                    X           X         |          6 |
      Mesothelioma Malignant               |                                           X                              |          1 |
      Osteosarcoma, Metastatic, Spleen     |          X           X                                X     X            |         10 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Osteosarcoma, Metastatic, Spleen     |                                                                          |          1 |
      Glandular, Osteosarcoma, Metastatic, |                                                                          |            |
           Spleen                          |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
      Fibrosarcoma, Metastatic, Spleen     |                                                                X         |          1 |
      Osteosarcoma, Metastatic, Spleen     |                                                             X            |          1 |
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                              +                           |   1        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  49                                                               
NTP Experiment-Test: 05020-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:14:36  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 4| 6|            |
                             DAY ON TEST   | 3| 3| 3| 5| 2| 3| 3| 2| 3| 3| 7| 2| 1| 2| 3| 5| 2| 2| 3| 3| 9| 1| 3| 1| 8|            |
                                           | 0| 1| 1| 9| 9| 0| 2| 9| 1| 2| 9| 1| 5| 9| 1| 9| 9| 8| 1| 2| 4| 6| 0| 5| 9|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|     A      |
    18 MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Squamous Cell Papilloma              |                                              X                           |          1 |
                                            __________________________________________________________________________|____________|
   Tooth                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Gingiva, Squamous Cell Carcinoma     |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pulmonary Artery, Fibrosarcoma,      |                                                                          |            |
          Metastatic, Spleen               |                                                                X         |          1 |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |                                     X                                    |          1 |
      Capsule, Fibrosarcoma, Metastatic,   |                                                                          |            |
           Spleen                          |                                                                X         |          1 |
      Capsule, Osteosarcoma, Metastatic,   |                                                                          |            |
           Spleen                          |                                                             X            |          1 |
      Medulla, Fibrosarcoma, Metastatic,   |                                                                          |            |
           Spleen                          |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Leukemia Mononuclear                 |                                     X                                    |          1 |
      Pheochromocytoma Malignant           |                                                                          |          1 |
      Pheochromocytoma Benign              |             X  X        X              X  X  X     X     X     X         |         13 |
      Bilateral, Pheochromocytoma Benign   | X     X           X        X  X  X                                X     X|         12 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Adenoma                              |                                                                          |          1 |
      Carcinoma                            |                                           X                              |          1 |
      Fibrosarcoma, Metastatic, Spleen     |                                                    X           X         |          4 |
      Osteosarcoma, Metastatic, Spleen     |          X           X                                X                  |          7 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  M  +  +  +  +  +|  45        |
      Adenoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  46        |
      Pars Distalis, Adenoma               | X        X                             X                          X     X|         10 |
      Pars Distalis, Adenoma, Multiple     |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  A|  45        |
      C-Cell, Adenoma                      |    X  X           X                                   X           X      |          9 |
      C-Cell, Carcinoma                    |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  50                                                               
NTP Experiment-Test: 05020-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:14:36  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 4| 6|            |
                             DAY ON TEST   | 3| 3| 3| 5| 2| 3| 3| 2| 3| 3| 7| 2| 1| 2| 3| 5| 2| 2| 3| 3| 9| 1| 3| 1| 8|            |
                                           | 0| 1| 1| 9| 9| 0| 2| 9| 1| 2| 9| 1| 5| 9| 1| 9| 9| 8| 1| 2| 4| 6| 0| 5| 9|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|     A      |
    18 MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENERAL BODY SYSTEM - cont                |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
      Osteosarcoma, Metastatic, Spleen     |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosarcoma, Metastatic, Spleen     |                                              X                 X         |          2 |
      Osteosarcoma, Metastatic, Spleen     |                      X                                      X            |          3 |
      Sarcoma                              |                                  X                                       |          1 |
      Bilateral, Mesothelioma Malignant    |                                           X                              |          1 |
      Bilateral, Osteosarcoma, Metastatic, |                                                                          |            |
           Spleen                          |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Adenocarcinoma                       |                                                                          |          1 |
      Adenoma                              |                   X                                                      |          2 |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Fibrosarcoma, Metastatic, Spleen     |                                                                          |          1 |
      Osteosarcoma, Metastatic, Spleen     |                      X                                X     X            |          3 |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |             +        +  +  +     +  M     +  +     +  +  +  +     +  +   |  23        |
      Osteosarcoma, Metastatic, Spleen     |                                                             X            |          2 |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mesothelioma Malignant               |                                           X                              |          2 |
      Osteosarcoma, Metastatic, Spleen     |                                                                          |          3 |
      Bilateral, Interstitial Cell, Adenoma| X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X     X  X     X|         40 |
      Interstitial Cell, Adenoma           |                                                                      X   |          6 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   | +  +  +  +  +  +  +  +  +  +        +  +  +  +  +     +  +     +  +      |  31        |
      Leukemia Mononuclear                 |                                     X           X                        |          3 |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Osteosarcoma, Metastatic, Spleen     |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Mediastinal, Fibrosarcoma,           |                                                                          |            |
          Metastatic, Spleen               |                                                                          |          2 |
      Mediastinal, Leukemia Mononuclear    |                                     X           X                        |          3 |
      Mediastinal, Osteosarcoma,           |                                                                          |            |
          Metastatic, Spleen               |                      X                                      X            |          6 |
      Mediastinal, Pancreatic,             |                                                                          |            |
          Fibrosarcoma, Metastatic, Spleen |                                                                X         |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  51                                                               
NTP Experiment-Test: 05020-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:14:36  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 4| 6|            |
                             DAY ON TEST   | 3| 3| 3| 5| 2| 3| 3| 2| 3| 3| 7| 2| 1| 2| 3| 5| 2| 2| 3| 3| 9| 1| 3| 1| 8|            |
                                           | 0| 1| 1| 9| 9| 0| 2| 9| 1| 2| 9| 1| 5| 9| 1| 9| 9| 8| 1| 2| 4| 6| 0| 5| 9|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|     A      |
    18 MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Pancreatic, Mesothelioma Malignant   |                                           X                              |          1 |
      Renal, Leukemia Mononuclear          |                                     X                                    |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Leukemia Mononuclear                 |                                     X           X                        |          3 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +              +                 +     +     +     +                  |  10        |
      Leukemia Mononuclear                 |                                     X           X                        |          3 |
      Mediastinal, Osteosarcoma,           |                                                                          |            |
          Metastatic, Spleen               |                                                       X                  |          1 |
      Pancreatic, Fibrosarcoma, Metastatic,|                                                                          |            |
           Spleen                          |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibroma                              |                X                                                         |          2 |
      Fibrosarcoma                         | X                 X           X           X  X     X           X         |         17 |
      Hemangiosarcoma                      |                                                                          |          4 |
      Leukemia Mononuclear                 |                                     X           X                        |          3 |
      Mesothelioma Malignant               |                                           X                              |          1 |
      Osteosarcoma                         |       X  X  X        X  X              X              X  X  X            |         19 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  M  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  M  M  +  +  M  +|  36        |
      Leukemia Mononuclear                 |                                     X           X                        |          2 |
      Osteosarcoma, Metastatic, Spleen     |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  +  +  M  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  M  +  +  M  M|  36        |
      Fibroadenoma                         |                                                 X                        |          3 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|  49        |
      Keratoacanthoma                      |                                                                          |          1 |
      Subcutaneous Tissue, Fibroma         |                               X                          X               |          4 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Osteosarcoma, Metastatic, Spleen     |                                                                          |          2 |
      Diaphragm, Fibrosarcoma, Metastatic, |                                                                          |            |
           Spleen                          |                                                                X         |          3 |
      Diaphragm, Osteosarcoma, Metastatic, |                                                                          |            |
           Spleen                          |                                                       X                  |          2 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  52                                                               
NTP Experiment-Test: 05020-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:14:36  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 4| 6|            |
                             DAY ON TEST   | 3| 3| 3| 5| 2| 3| 3| 2| 3| 3| 7| 2| 1| 2| 3| 5| 2| 2| 3| 3| 9| 1| 3| 1| 8|            |
                                           | 0| 1| 1| 9| 9| 0| 2| 9| 1| 2| 9| 1| 5| 9| 1| 9| 9| 8| 1| 2| 4| 6| 0| 5| 9|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|     A      |
    18 MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                      +   |   1        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                      +   |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosarcoma, Metastatic, Spleen     |                                                                X         |          5 |
      Hemangiosarcoma, Metastatic, Spleen  |                                                                          |          1 |
      Leukemia Mononuclear                 |                                     X           X                        |          3 |
      Osteosarcoma, Metastatic, Spleen     |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|  46        |
      Nasolacrimal Duct, Squamous Cell     |                                                                          |            |
          Carcinoma                        |       X                                                                  |          1 |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     |    +        +        +  +  +           +                 +               |  14        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +|  43        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosarcoma, Metastatic, Spleen     |                                                    X                     |          3 |
      Leukemia Mononuclear                 |                                     X           X                        |          3 |
      Osteosarcoma, Metastatic, Spleen     |                      X                                X     X            |          6 |
      Renal Tubule, Adenoma                |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Ureter                                  | +  +     +  +  +  +  +  +  +     +     +  +  +  +  +  +  +  +     +  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Urethra                                 | +        +        +                    +                       +         |  11        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Fibrosarcoma, Metastatic, Spleen     |                                                                X         |          2 |
      Osteosarcoma, Metastatic, Spleen     |                                                             X            |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                     X           X                        |          3 |
      Mesothelioma Malignant               |                                           X                              |          2 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  53                                                               
NTP Experiment-Test: 05020-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:14:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 5|             
                             DAY ON TEST   | 6| 1| 2| 3| 2| 3| 2| 3| 3| 2| 4| 7| 1| 2| 2| 2| 3| 3| 2| 3| 3| 3| 3| 2| 7|             
                                           | 1| 6| 9| 0| 9| 0| 9| 2| 2| 9| 9| 6| 0| 9| 4| 9| 1| 1| 9| 2| 1| 1| 3| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    6 MG/KG                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +                             +  +        +     +                 +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +                             +  +                                +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +                             +  A                                A  M  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +                             +  A                                A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | M                             A  +                                +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +                             +  +                                +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +                             +  A                                +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +                             +  A                                A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +                             A  +                                A  +  +|             
      Polyp Adenomatous                    |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma             |    X                                                                     |             
      Hepatocellular Carcinoma, Multiple   |                                                          X               |             
      Leukemia Mononuclear                 |                                                                          |             
      Neoplastic Nodule                    |                                                             X            |             
                                            __________________________________________________________________________|             
   Mesentery                               | +  +                          +                                      +  +|             
      Fibrosarcoma, Metastatic, Spleen     |                                                                          |             
      Pheochromocytoma Malignant,          |                                                                          |             
          Metastatic, Adrenal Gland        |                                                                      X   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +                    +     +  A              +                 +  +  +|             
      Fibrosarcoma, Metastatic, Spleen     |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +                             +  A        +                       +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +                          +  A                                +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +                          +  A                                +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +                          +  A                                +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   | +                             +  +                                +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +                             +  +        +                       +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +     +  +           +     +  +        +     +              +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Pheochromocytoma Malignant           |          X                                                               |             
      Pheochromocytoma Benign              |             X                    X     X  X  X                           |             
      Bilateral, Pheochromocytoma Benign   |                      X                                                   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +                             +  A                                +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +                             +  M                                +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +        +              +  +  A  +                             +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  54                                                               
NTP Experiment-Test: 05020-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:14:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 5|             
                             DAY ON TEST   | 6| 1| 2| 3| 2| 3| 2| 3| 3| 2| 4| 7| 1| 2| 2| 2| 3| 3| 2| 3| 3| 3| 3| 2| 7|             
                                           | 1| 6| 9| 0| 9| 0| 9| 2| 2| 9| 9| 6| 0| 9| 4| 9| 1| 1| 9| 2| 1| 1| 3| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    6 MG/KG                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Distalis, Adenoma               |    X        X              X                                      X     X|             
      Pars Distalis, Carcinoma             |                                     X                                    |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +                             +  A                                +  +  +|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +        +           +     +  +                                +  +  +|             
      Mesothelioma Malignant               |    X                                                                     |             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +     +        +        +  +  +  +                                +  +  +|             
      Adenoma                              |       X        X           X                                             |             
                                            __________________________________________________________________________|             
   Prostate                                | +           +                 +  +                                +  +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelioma Malignant               |    X                                                                     |             
      Bilateral, Interstitial Cell, Adenoma|    X     X  X  X  X  X     X           X  X  X  X  X     X  X  X         |             
      Interstitial Cell, Adenoma           |       X                 X           X                 X              X  X|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   | +  +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +         |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Femoral, Leukemia Mononuclear        |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +                             +  +        +     +                 +  +  +|             
      Mediastinal, Leukemia Mononuclear    |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +                             +  A        +                       +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                                                                      +   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosarcoma                         |                         X                                                |             
      Leukemia Mononuclear                 |                                                                          |             
      Osteosarcoma                         |                                                 X                        |             
                                            __________________________________________________________________________|             
   Thymus                                  | +                       +     +  +        +     +                 M  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M     +              +  +  +  +  +           +                    +  +  +|             
      Fibroadenoma                         |                      X  X                    X                           |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +              +  +  +  +  +           +                    +  +  +|             
      Keratoacanthoma                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  55                                                               
NTP Experiment-Test: 05020-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:14:36  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 5|             
                             DAY ON TEST   | 6| 1| 2| 3| 2| 3| 2| 3| 3| 2| 4| 7| 1| 2| 2| 2| 3| 3| 2| 3| 3| 3| 3| 2| 7|             
                                           | 1| 6| 9| 0| 9| 0| 9| 2| 2| 9| 9| 6| 0| 9| 4| 9| 1| 1| 9| 2| 1| 1| 3| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    6 MG/KG                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Squamous Cell Papilloma              |                                                                          |             
      Sebaceous Gland, Adenoma             |    X                                                                     |             
      Subcutaneous Tissue, Fibroma         |                         X                                                |             
      Subcutaneous Tissue, Fibrosarcoma    | X                                                                        |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         | +                             +  +                                +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +                             +  A                                +  +  +|             
      Cerebellum, Meningioma Malignant     |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             | +                                                                        |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +                                +                                +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Squamous Cell Carcinoma              |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +                             +  +                                +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +                             +  +        +     +                 +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |          +  +  +     +  +  +                             +               |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +                             +  +                                +  +  M|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosarcoma, Metastatic, Spleen     |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Ureter                                  | +           +  +     +  +     +  +  +        +     +        +     +  +   |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                                   +      |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +           +                 +  +                                +  +  +|             
      Papilloma                            |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Mesothelioma Malignant               |    X                                                                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  56                                                               
NTP Experiment-Test: 05020-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:14:36  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 3| 7| 4| 7| 4|            |
                             DAY ON TEST   | 3| 3| 3| 7| 8| 1| 3| 0| 3| 3| 3| 3| 3| 3| 2| 3| 3| 7| 3| 1| 3| 2| 7| 3| 9|            |
                                           | 2| 2| 0| 8| 6| 8| 2| 2| 0| 1| 2| 1| 2| 2| 9| 2| 2| 0| 1| 1| 8| 9| 6| 2| 8|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|     A      |
    6 MG/KG                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |          +                                         +        +     +     +|  13        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |          +                 +                       +        +     +     +|  12        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |          +                 +                       A        A     A     +|   6        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |          +                                         +        +     +     +|   9        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |          +                                         A        +     +     +|   8        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |          +  +                                      +        +     +     +|  12        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |          +                                         +        +     +     +|  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |          A                                         A        +     A     +|   6        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |          +  +                                      A        +     A     +|   8        |
      Polyp Adenomatous                    |             X                                                            |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hepatocellular Carcinoma             |                                                                          |          1 |
      Hepatocellular Carcinoma, Multiple   |                                                                          |          1 |
      Leukemia Mononuclear                 |                         X                                               X|          2 |
      Neoplastic Nodule                    |                                  X     X                                 |          3 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |          +           +                             +        +     +     +|  11        |
      Fibrosarcoma, Metastatic, Spleen     |                      X                                                   |          1 |
      Pheochromocytoma Malignant,          |                                                                          |            |
          Metastatic, Adrenal Gland        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                |          +           +                             +        +     +     +|  14        |
      Fibrosarcoma, Metastatic, Spleen     |                      X                                                   |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |          +                                         +        +     +     +|  11        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |          +                                         +        +     +     +|  11        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |          +                                         +        +     +     +|  11        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |          +                                         +        +     +     +|  11        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                    +        +     +     +|  10        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |          +                                         +        +     +     +|  12        |
                                            __________________________________________________________________________|____________|
   Heart                                   |          +     +  +           +           +  +     +        +     +     +|  23        |
      Leukemia Mononuclear                 |                                                                         X|          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |                                                                         X|          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|  48        |
      Leukemia Mononuclear                 |                                                                         X|          1 |
      Pheochromocytoma Malignant           |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  57                                                               
NTP Experiment-Test: 05020-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:14:36  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 3| 7| 4| 7| 4|            |
                             DAY ON TEST   | 3| 3| 3| 7| 8| 1| 3| 0| 3| 3| 3| 3| 3| 3| 2| 3| 3| 7| 3| 1| 3| 2| 7| 3| 9|            |
                                           | 2| 2| 0| 8| 6| 8| 2| 2| 0| 1| 2| 1| 2| 2| 9| 2| 2| 0| 1| 1| 8| 9| 6| 2| 8|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|     A      |
    6 MG/KG                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Pheochromocytoma Benign              | X  X  X                    X                                             |          9 |
      Bilateral, Pheochromocytoma Benign   |                         X     X              X                       X   |          5 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |          +                                         +        +     +     +|  10        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |          +                                         +        +     +     +|  10        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |          +     +  +                    +        +  +     +  +     +     +|  19        |
      Pars Distalis, Adenoma               |          X     X  X                             X        X              X|         11 |
      Pars Distalis, Carcinoma             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |          +                                         +        +     +     +|  10        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |          +     +        +  +     +  +  +  +  +     +  +  +  +  +  +  +  +|  26        |
      Mesothelioma Malignant               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Penis                                   |                                                                         +|   1        |
      Leukemia Mononuclear                 |                                                                         X|          1 |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |          +                                         M        +  +  +     +|  15        |
      Adenoma                              |                                                                X         |          4 |
                                            __________________________________________________________________________|____________|
   Prostate                                |          +           +                             +        +     +     +|  13        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |          +           +                             +              +     +|   5        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mesothelioma Malignant               |                                                                          |          1 |
      Bilateral, Interstitial Cell, Adenoma| X  X  X     X  X  X  X  X  X  X  X  X  X  X     X     X        X     X   |         33 |
      Interstitial Cell, Adenoma           |          X                                   X     X     X        X      |         11 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   | +  +  +        +  +  +  +  +  +  +  +  +  +  +  +     +  +     +     +  +|  39        |
      Leukemia Mononuclear                 |                                                                         X|          1 |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |                         X                                                |          1 |
      Femoral, Leukemia Mononuclear        |                                                                         X|          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |          +        +        +                       +        +     +     +|  15        |
      Mediastinal, Leukemia Mononuclear    |                                                                         X|          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |          +        +                                +        +     +     +|  12        |
      Leukemia Mononuclear                 |                                                                         X|          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                            +                                             |   2        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosarcoma                         |                      X                                                   |          2 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  58                                                               
NTP Experiment-Test: 05020-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:14:36  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 3| 7| 4| 7| 4|            |
                             DAY ON TEST   | 3| 3| 3| 7| 8| 1| 3| 0| 3| 3| 3| 3| 3| 3| 2| 3| 3| 7| 3| 1| 3| 2| 7| 3| 9|            |
                                           | 2| 2| 0| 8| 6| 8| 2| 2| 0| 1| 2| 1| 2| 2| 9| 2| 2| 0| 1| 1| 8| 9| 6| 2| 8|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|     A      |
    6 MG/KG                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Leukemia Mononuclear                 |                         X                                               X|          2 |
      Osteosarcoma                         |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  |          +                                         +        +     +     +|  13        |
      Leukemia Mononuclear                 |                                                                         X|          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |          M                                         +        +     +     M|  13        |
      Fibroadenoma                         |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Skin                                    |       +  +                                         +     +  +     +     +|  19        |
      Keratoacanthoma                      |                                                          X               |          1 |
      Squamous Cell Papilloma              |       X                                                                  |          1 |
      Sebaceous Gland, Adenoma             |                                                                          |          1 |
      Subcutaneous Tissue, Fibroma         |                                                                          |          1 |
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |          +                                         +        +     +     +|  11        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |          +                                         +        +     +     +|  10        |
      Cerebellum, Meningioma Malignant     |                                                             X            |          1 |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                             +            |   2        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |          +     +                                   +        +     +     +|  11        |
      Leukemia Mononuclear                 |                                                                         X|          1 |
      Squamous Cell Carcinoma              |                X                                                         |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    |          M                                         +        +     +     +|  10        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |          +                                         +        +     +     +|  13        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |    +  +              +  +  +                                   +         |  13        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                    +        +     +     +|   9        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Fibrosarcoma, Metastatic, Spleen     |                      X                                                   |          1 |
      Leukemia Mononuclear                 |                                                                         X|          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  59                                                               
NTP Experiment-Test: 05020-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:14:36  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 3| 7| 4| 7| 4|            |
                             DAY ON TEST   | 3| 3| 3| 7| 8| 1| 3| 0| 3| 3| 3| 3| 3| 3| 2| 3| 3| 7| 3| 1| 3| 2| 7| 3| 9|            |
                                           | 2| 2| 0| 8| 6| 8| 2| 2| 0| 1| 2| 1| 2| 2| 9| 2| 2| 0| 1| 1| 8| 9| 6| 2| 8|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|     A      |
    6 MG/KG                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ureter                                  |       +  +     +     +        +  +     +  +        +     +  +  +  +     +|  27        |
                                            __________________________________________________________________________|____________|
   Urethra                                 |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |          +                                         +        +     +     +|  12        |
      Papilloma                            |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                         X                                               X|          2 |
      Mesothelioma Malignant               |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
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