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TR 351 Rat Pathology Tables


                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                         PARA-CHLOROANILINE


NTP Experiment-Test: 05020-01                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/03/94
Route: GAVAGE                                                                                                     Time: 18:08:59




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  000106478

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05020-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 18:08:59  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   VEHICLE      2 MG/KG      6 MG/KG      18 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Dead                                              15            5           11            8                                     
    Moribund                                           8            6            3            5                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                27           39           36           37                                     
  Animals Examined Microscopically                    50           50           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (40)         (4)          (3)          (46)                                   
   Intestine Large, Colon                             (47)         (6)          (8)          (46)                                   
   Intestine Small, Duodenum                          (49)         (3)          (8)          (48)                                   
      Adenocarcinoma, Metastatic, Uterus               1 (2%)                                                                       
   Intestine Small, Ileum                             (40)         (3)          (2)          (45)                                   
   Liver                                              (50)         (50)         (50)         (50)                                   
      Neoplastic Nodule                                1 (2%)       1 (2%)                                                          
      Sarcoma, Metastatic, Skin                                                               1 (2%)                                
      Artery, Adenocarcinoma, Metastatic, Uterus       1 (2%)                                                                       
   Mesentery                                          (49)         (7)          (11)         (47)                                   
      Adenocarcinoma, Metastatic, Uterus               1 (2%)                                 1 (2%)                                
      Lipoma                                                                     1 (9%)                                             
   Pancreas                                           (50)         (6)          (12)         (49)                                   
      Adenocarcinoma, Metastatic, Uterus               1 (2%)                                 1 (2%)                                
   Salivary Glands                                    (50)         (8)          (12)         (49)                                   
      Carcinoma, Metastatic, Zymbal's Gland                         1 (13%)                                                         
   Stomach, Forestomach                               (50)         (5)          (9)          (48)                                   
   Stomach, Glandular                                 (50)         (4)          (9)          (48)                                   
      Adenocarcinoma, Metastatic, Uterus               1 (2%)                                                                       
   Tongue                                             (3)                       (1)                                                 
      Squamous Cell Papilloma                          2 (67%)                   1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (7)          (10)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   2                                                               
NTP Experiment-Test: 05020-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 18:08:59  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   VEHICLE      2 MG/KG      6 MG/KG      18 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (50)         (50)         (50)                                   
      Adenoma                                                       1 (2%)                                                          
      Capsule, Adenocarcinoma, Metastatic, Uterus      1 (2%)                                                                       
   Adrenal Gland, Medulla                             (50)         (50)         (50)         (50)                                   
      Pheochromocytoma Benign                          2 (4%)       3 (6%)       1 (2%)       6 (12%)                               
   Islets, Pancreatic                                 (50)         (5)          (9)          (48)                                   
      Adenoma                                          1 (2%)                                 1 (2%)                                
   Pituitary Gland                                    (50)         (33)         (35)         (50)                                   
      Pars Distalis, Adenoma                          20 (40%)     13 (39%)     17 (49%)     20 (40%)                               
      Pars Distalis, Adenoma, Multiple                 1 (2%)                                 3 (6%)                                
      Pars Distalis, Carcinoma                                                                1 (2%)                                
   Thyroid Gland                                      (49)         (6)          (11)         (48)                                   
      Bilateral, C-Cell, Adenoma                       1 (2%)                                                                       
      C-Cell, Adenoma                                  4 (8%)                    1 (9%)       5 (10%)                               
      C-Cell, Carcinoma                                1 (2%)                    1 (9%)       1 (2%)                                
      Follicular Cell, Adenoma                                                                1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (45)         (5)          (11)         (48)                                   
      Adenoma                                          1 (2%)       1 (20%)      1 (9%)       4 (8%)                                
   Ovary                                              (50)         (15)         (15)         (49)                                   
      Granulosa-Theca Tumor Benign                                  2 (13%)                                                         
      Bilateral, Adenocarcinoma, Metastatic, Uterus    1 (2%)                                                                       
   Uterus                                             (50)         (14)         (20)         (50)                                   
      Adenocarcinoma                                   1 (2%)       1 (7%)                    1 (2%)                                
      Fibroma                                                                                 1 (2%)                                
      Polyp Stromal                                    4 (8%)       6 (43%)      7 (35%)      6 (12%)                               
      Polyp Stromal, Multiple                          1 (2%)                                                                       
   Vagina                                                                                    (1)                                    
      Polyp                                                                                   1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Blood                                              (32)         (45)         (37)         (43)                                   
   Bone Marrow                                        (50)         (48)         (50)         (47)                                   
   Lymph Node                                         (50)         (12)         (17)         (50)                                   
      Mediastinal, Adenocarcinoma, Metastatic,                                                                                      
           Uterus                                      1 (2%)                                 1 (2%)                                
                                                             Page   3                                                               
NTP Experiment-Test: 05020-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 18:08:59  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   VEHICLE      2 MG/KG      6 MG/KG      18 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
      Mediastinal, Sarcoma, Metastatic, Skin                                                  1 (2%)                                
   Lymph Node, Mandibular                             (49)         (7)          (14)         (49)                                   
   Lymph Node, Mesenteric                             (7)          (4)          (1)          (9)                                    
   Spleen                                             (50)         (50)         (50)         (50)                                   
      Adenocarcinoma, Metastatic, Uterus               1 (2%)                                 1 (2%)                                
      Fibrosarcoma                                                               1 (2%)                                             
      Osteosarcoma                                                                            1 (2%)                                
   Thymus                                             (42)         (8)          (11)         (44)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (49)         (17)         (22)         (50)                                   
      Adenoma                                          1 (2%)       1 (6%)                    3 (6%)                                
      Fibroadenoma                                     6 (12%)      8 (47%)     12 (55%)      6 (12%)                               
      Fibroadenoma, Multiple                           2 (4%)       2 (12%)      1 (5%)                                             
      Sarcoma, Metastatic, Skin                                                               1 (2%)                                
   Skin                                               (50)         (20)         (21)         (50)                                   
      Basosquamous Tumor Benign                        1 (2%)                                                                       
      Subcutaneous Tissue, Fibroma                     2 (4%)       2 (10%)                   2 (4%)                                
      Subcutaneous Tissue, Fibrosarcoma                             1 (5%)                                                          
      Subcutaneous Tissue, Neurofibroma                             1 (5%)                                                          
      Subcutaneous Tissue, Sarcoma                                                            1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                    (49)         (5)          (10)         (50)                                   
      Sarcoma, Metastatic, Skin                                                               1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (5)          (10)         (50)                                   
      Astrocytoma Benign                               1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (49)         (5)          (11)         (50)                                   
      Adenocarcinoma, Metastatic, Uterus               1 (2%)                                 1 (2%)                                
      Sarcoma, Metastatic, Skin                                                               1 (2%)                                
   Nose                                               (49)         (4)          (11)         (49)                                   
      Osteosarcoma                                                               1 (9%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   4                                                               
NTP Experiment-Test: 05020-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 18:08:59  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   VEHICLE      2 MG/KG      6 MG/KG      18 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Zymbal's Gland                                                  (2)                                                              
      Carcinoma                                                     2 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)                                   
      Adenocarcinoma, Metastatic, Uterus               1 (2%)                                 1 (2%)                                
      Lipoma                                                        1 (2%)                                                          
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Leukemia Mononuclear                            10 (20%)      2 (4%)       1 (2%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   5                                                               
NTP Experiment-Test: 05020-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 18:08:59  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   VEHICLE      2 MG/KG      6 MG/KG      18 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            37          30          34          40                                       
     Total Primary Neoplasms                           63          48          46          65                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 32          27          31          36                                       
     Total Benign Neoplasms                            51          42          42          59                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              10           6           4           6                                       
     Total Malignant Neoplasms                         12           6           4           6                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              1           1                       2                                       
     Total Metastatic Neoplasm                         11           1                      11                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   6                                                               
NTP Experiment-Test: 05020-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 18:08:59  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     VEHICLE      2 MG/KG      6 MG/KG      18 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          49           50           50           50                                     
  Early Deaths                                                                                                                      
    Dead                                               5            5            9           17                                     
    Dosing Accident                                                              2            1                                     
    Moribund                                          26           13            7           11                                     
  Survivors                                                                                                                         
    Dead                                                                                      1                                     
    Terminal Sacrifice                                18           32           32           20                                     
  Animals Examined Microscopically                    49           50           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (46)         (5)          (6)          (44)                                   
      Colon, Rectum, Osteosarcoma, Metastatic,                                                                                      
           Spleen                                                                             1 (2%)                                
   Intestine Large, Rectum                            (47)         (5)          (8)          (44)                                   
   Intestine Small, Duodenum                          (48)         (5)          (10)         (46)                                   
      Fibrosarcoma, Metastatic, Spleen                                                        2 (4%)                                
      Osteosarcoma, Metastatic, Spleen                                                        3 (7%)                                
      Ileum, Jejunum, Osteosarcoma, Metastatic,                                                                                     
           Spleen                                                                             1 (2%)                                
   Intestine Small, Jejunum                           (46)         (6)          (8)          (41)                                   
      Adenocarcinoma                                                1 (17%)                                                         
      Osteosarcoma, Metastatic, Spleen                                                        1 (2%)                                
      Polyp Adenomatous                                                          1 (13%)                                            
   Liver                                              (49)         (50)         (49)         (49)                                   
      Fibrosarcoma, Metastatic, Spleen                                                        4 (8%)                                
      Hepatocellular Carcinoma                         1 (2%)       1 (2%)       1 (2%)                                             
      Hepatocellular Carcinoma, Multiple                                         1 (2%)                                             
      Neoplastic Nodule                                             5 (10%)      3 (6%)                                             
      Osteosarcoma, Metastatic, Spleen                                                        8 (16%)                               
   Mesentery                                          (47)         (11)         (11)         (48)                                   
      Fibrosarcoma, Metastatic, Spleen                                           1 (9%)       9 (19%)                               
      Osteosarcoma, Metastatic, Spleen                                                       11 (23%)                               
      Pheochromocytoma Malignant, Metastatic,                                                                                       
          Adrenal Gland                                                          1 (9%)                                             
      Sarcoma                                                       1 (9%)                                                          
   Pancreas                                           (48)         (8)          (14)         (47)                                   
      Fibrosarcoma, Metastatic, Spleen                                           1 (7%)       6 (13%)                               
      Osteosarcoma, Metastatic, Spleen                                                       10 (21%)                               
      Acinus, Adenoma                                  1 (2%)                                                                       
   Salivary Glands                                    (49)         (6)          (11)         (49)                                   
   Stomach, Forestomach                               (47)         (6)          (11)         (46)                                   
                                                             Page   7                                                               
NTP Experiment-Test: 05020-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 18:08:59  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     VEHICLE      2 MG/KG      6 MG/KG      18 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - cont                                                                                                            
      Osteosarcoma, Metastatic, Spleen                                                        1 (2%)                                
      Glandular, Osteosarcoma, Metastatic, Spleen                                             1 (2%)                                
   Stomach, Glandular                                 (48)         (6)          (11)         (45)                                   
      Fibrosarcoma, Metastatic, Spleen                                                        1 (2%)                                
      Osteosarcoma, Metastatic, Spleen                                                        1 (2%)                                
   Tongue                                             (2)          (1)                       (1)                                    
      Squamous Cell Papilloma                          2 (100%)     1 (100%)                  1 (100%)                              
   Tooth                                              (49)         (5)          (10)         (49)                                   
      Gingiva, Squamous Cell Carcinoma                                                        1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (49)         (8)          (12)         (50)                                   
      Pulmonary Artery, Fibrosarcoma, Metastatic,                                                                                   
           Spleen                                                                             1 (2%)                                
   Heart                                              (49)         (18)         (23)         (50)                                   
      Osteosarcoma, Metastatic, Bone                   1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (49)         (50)         (49)         (49)                                   
      Adenoma                                          1 (2%)                                                                       
      Capsule, Fibrosarcoma, Metastatic, Spleen                                               1 (2%)                                
      Capsule, Osteosarcoma, Metastatic, Spleen                                               1 (2%)                                
      Medulla, Fibrosarcoma, Metastatic, Spleen                                               1 (2%)                                
   Adrenal Gland, Medulla                             (49)         (49)         (48)         (48)                                   
      Osteosarcoma, Metastatic, Bone                                1 (2%)                                                          
      Pheochromocytoma Malignant                       1 (2%)                    1 (2%)       1 (2%)                                
      Pheochromocytoma Benign                         10 (20%)     12 (24%)      9 (19%)     13 (27%)                               
      Bilateral, Pheochromocytoma Benign               3 (6%)       2 (4%)       5 (10%)     12 (25%)                               
   Islets, Pancreatic                                 (48)         (4)          (10)         (46)                                   
      Adenoma                                          3 (6%)                                 1 (2%)                                
      Carcinoma                                                                               1 (2%)                                
      Fibrosarcoma, Metastatic, Spleen                                                        4 (9%)                                
      Osteosarcoma, Metastatic, Spleen                                                        7 (15%)                               
   Parathyroid Gland                                  (48)         (7)          (10)         (45)                                   
      Adenoma                                                       1 (14%)                   1 (2%)                                
   Pituitary Gland                                    (47)         (18)         (19)         (46)                                   
      Pars Distalis, Adenoma                          19 (40%)     13 (72%)     11 (58%)     10 (22%)                               
      Pars Distalis, Adenoma, Multiple                 1 (2%)                                 1 (2%)                                
      Pars Distalis, Carcinoma                                                   1 (5%)                                             
      Pars Intermedia, Adenoma                         1 (2%)                                                                       
   Thyroid Gland                                      (48)         (8)          (10)         (45)                                   
      C-Cell, Adenoma                                  8 (17%)      2 (25%)                   9 (20%)                               
      C-Cell, Adenoma, Multiple                        1 (2%)                                                                       
                                                             Page   8                                                               
NTP Experiment-Test: 05020-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 18:08:59  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     VEHICLE      2 MG/KG      6 MG/KG      18 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
      C-Cell, Carcinoma                                1 (2%)       1 (13%)                   1 (2%)                                
      Follicular Cell, Adenocarcinoma                               1 (13%)                                                         
      Follicular Cell, Adenoma                                      1 (13%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                                                                (1)                                    
      Osteosarcoma, Metastatic, Spleen                                                        1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (49)         (20)         (26)         (50)                                   
      Fibrosarcoma, Metastatic, Spleen                                                        2 (4%)                                
      Osteosarcoma, Metastatic, Spleen                                                        3 (6%)                                
      Sarcoma                                                                                 1 (2%)                                
      Bilateral, Osteosarcoma, Metastatic, Spleen                                             1 (2%)                                
   Penis                                                                        (1)                                                 
   Preputial Gland                                    (46)         (12)         (15)         (48)                                   
      Adenocarcinoma                                                                          1 (2%)                                
      Adenoma                                          1 (2%)       7 (58%)      4 (27%)      2 (4%)                                
   Prostate                                           (49)         (6)          (13)         (48)                                   
      Fibrosarcoma, Metastatic, Spleen                                                        1 (2%)                                
      Osteosarcoma, Metastatic, Spleen                                                        3 (6%)                                
   Seminal Vesicle                                    (36)         (3)          (5)          (23)                                   
      Osteosarcoma, Metastatic, Spleen                                                        2 (9%)                                
   Testes                                             (49)         (46)         (50)         (50)                                   
      Osteosarcoma, Metastatic, Spleen                                                        3 (6%)                                
      Bilateral, Interstitial Cell, Adenoma           25 (51%)     38 (83%)     33 (66%)     40 (80%)                               
      Interstitial Cell, Adenoma                      11 (22%)      6 (13%)     11 (22%)      6 (12%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Blood                                              (44)         (45)         (39)         (31)                                   
   Bone Marrow                                        (49)         (50)         (49)         (50)                                   
      Osteosarcoma, Metastatic, Spleen                                                        1 (2%)                                
   Lymph Node                                         (49)         (16)         (15)         (49)                                   
      Mediastinal, Fibrosarcoma, Metastatic, Spleen                                           2 (4%)                                
      Mediastinal, Osteosarcoma, Metastatic, Spleen                                           6 (12%)                               
      Mediastinal, Pancreatic, Fibrosarcoma,                                                                                        
          Metastatic, Spleen                                                                  1 (2%)                                
   Lymph Node, Mandibular                             (48)         (7)          (12)         (48)                                   
   Lymph Node, Mesenteric                             (10)         (5)          (2)          (10)                                   
      Mediastinal, Osteosarcoma, Metastatic, Spleen                                           1 (10%)                               
      Pancreatic, Fibrosarcoma, Metastatic, Spleen                                            1 (10%)                               
                                                             Page   9                                                               
NTP Experiment-Test: 05020-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 18:08:59  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     VEHICLE      2 MG/KG      6 MG/KG      18 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
   Spleen                                             (49)         (50)         (50)         (50)                                   
      Fibroma                                                                                 2 (4%)                                
      Fibrosarcoma                                                  1 (2%)       2 (4%)      17 (34%)                               
      Hemangiosarcoma                                                                         4 (8%)                                
      Osteosarcoma                                                               1 (2%)      19 (38%)                               
   Thymus                                             (43)         (5)          (13)         (36)                                   
      Osteosarcoma, Metastatic, Spleen                                                        1 (3%)                                
      Thymoma Benign                                                1 (20%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (32)         (6)          (13)         (36)                                   
      Fibroadenoma                                     1 (3%)       2 (33%)      3 (23%)      3 (8%)                                
   Skin                                               (47)         (18)         (19)         (49)                                   
      Basal Cell Adenoma                                            1 (6%)                                                          
      Basosquamous Tumor Benign                        1 (2%)       1 (6%)                                                          
      Keratoacanthoma                                  2 (4%)       1 (6%)       1 (5%)       1 (2%)                                
      Squamous Cell Carcinoma                                       1 (6%)                                                          
      Squamous Cell Papilloma                                                    1 (5%)                                             
      Sebaceous Gland, Adenoma                                                   1 (5%)                                             
      Subcutaneous Tissue, Fibroma                     3 (6%)       2 (11%)      1 (5%)       4 (8%)                                
      Subcutaneous Tissue, Fibrosarcoma                1 (2%)       2 (11%)      1 (5%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (48)         (50)         (49)         (50)                                   
      Cranium, Osteosarcoma                                         1 (2%)                                                          
      Rib, Osteosarcoma                                1 (2%)                                                                       
   Skeletal Muscle                                    (47)         (6)          (11)         (50)                                   
      Osteosarcoma, Metastatic, Bone                   1 (2%)       1 (17%)                                                         
      Osteosarcoma, Metastatic, Spleen                                                        2 (4%)                                
      Diaphragm, Fibrosarcoma, Metastatic, Spleen                                             3 (6%)                                
      Diaphragm, Osteosarcoma, Metastatic, Spleen                                             2 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (49)         (5)          (10)         (50)                                   
      Astrocytoma Benign                               1 (2%)                                                                       
      Ependymoma Malignant                             1 (2%)                                                                       
      Cerebellum, Meningioma Malignant                                           1 (10%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page  10                                                               
NTP Experiment-Test: 05020-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 18:08:59  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     VEHICLE      2 MG/KG      6 MG/KG      18 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (49)         (7)          (11)         (50)                                   
      Alveolar/Bronchiolar Adenoma                     1 (2%)                                                                       
      Fibrosarcoma, Metastatic, Spleen                                                        5 (10%)                               
      Hemangiosarcoma, Metastatic, Spleen                                                     1 (2%)                                
      Osteosarcoma, Metastatic, Bone                                1 (14%)                                                         
      Osteosarcoma, Metastatic, Spleen                                                        3 (6%)                                
      Squamous Cell Carcinoma                                                    1 (9%)                                             
   Nose                                               (48)         (5)          (10)         (46)                                   
      Polyp                                            1 (2%)                                                                       
      Nasolacrimal Duct, Squamous Cell Carcinoma                                              1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (7)          (11)         (13)         (14)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (48)         (50)         (49)         (50)                                   
      Fibrosarcoma, Metastatic, Spleen                                           1 (2%)       3 (6%)                                
      Osteosarcoma, Metastatic, Bone                                1 (2%)                                                          
      Osteosarcoma, Metastatic, Spleen                                                        6 (12%)                               
      Renal Tubule, Adenoma                                                                   1 (2%)                                
   Ureter                                             (47)         (24)         (27)         (44)                                   
   Urethra                                            (21)         (3)          (1)          (11)                                   
   Urinary Bladder                                    (47)         (7)          (12)         (46)                                   
      Fibrosarcoma, Metastatic, Spleen                                                        2 (4%)                                
      Osteosarcoma, Metastatic, Spleen                                                        1 (2%)                                
      Papilloma                                                                  1 (8%)                                             
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(49)        *(50)        *(50)        *(50)                                   
      Leukemia Mononuclear                            21 (43%)      3 (6%)       2 (4%)       3 (6%)                                
      Mesothelioma Malignant                           1 (2%)       3 (6%)       1 (2%)       2 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  11                                                               
NTP Experiment-Test: 05020-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 18:08:59  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     VEHICLE      2 MG/KG      6 MG/KG      18 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            46          49          49          49                                       
     Total Primary Neoplasms                          125         112          98         159                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 44          49          47          47                                       
     Total Benign Neoplasms                            97          96          85         107                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              28          14          12          43                                       
     Total Malignant Neoplasms                         28          16          13          52                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              1           1           2          23                                       
     Total Metastatic Neoplasm                          2           4           4         132                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  12                                                               
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