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TR 351 Rat Pathology Tables

NTP Experiment-Test: 05020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97
Route: GAVAGE                                                                                                     Time: 13:22:49




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  000106478

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All






































                                                              Page   1

NTP Experiment-Test: 05020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:22:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 7| 1| 6| 7| 7| 7| 4| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 3| 7| 2| 7| 7|             
                             DAY ON TEST   | 1| 5| 3| 8| 1| 3| 3| 3| 8| 3| 3| 3| 2| 2| 3| 3| 2| 3| 3| 1| 6| 3| 0| 0| 2|             
                                           | 9| 7| 2| 9| 8| 1| 0| 2| 2| 1| 0| 7| 8| 9| 1| 7| 9| 0| 2| 4| 9| 1| 0| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    VEHICLE                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                         4        4           4                          3|             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  A  +  +  A  A  +  +  +  +  +  +  +  A  +  +  +  M|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  A|             
      Parasite Metazoan                    |                                        X                    X            |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  M|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | A  +  +  +  +  +  +  +  A  +  +  A  M  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  A  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | X  X  X     X  X  X  X     X  X  X     X  X     X  X  X        X        X|             
      Degeneration, Fatty                  |                                                                      4   |             
      Fibrosis                             |    2                                                                     |             
      Hepatodiaphragmatic Nodule           |                   X                                                      |             
      Inflammation, Chronic                | 1     2        1  2  2     1  1        2     3  1              1  3     1|             
      Inflammation, Necrotizing            |          2                                                               |             
      Vacuolization Cytoplasmic            |                                     2                                    |             
      Bile Duct, Hyperplasia               |                                  2                       2        2      |             
                                            __________________________________________________________________________|             
   Mesentery                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      | 2                          2  2        1     1     1           2         |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                                      3   |             
      Hyperkeratosis                       |                                                                      2   |             
      Inflammation, Chronic Active         |                                                                      4   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Necrosis, Coagulative                |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |             +                                                        +   |             
                                            __________________________________________________________________________|             
   Tooth                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:22:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 7| 1| 6| 7| 7| 7| 4| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 3| 7| 2| 7| 7|             
                             DAY ON TEST   | 1| 5| 3| 8| 1| 3| 3| 3| 8| 3| 3| 3| 2| 2| 3| 3| 2| 3| 3| 1| 6| 3| 0| 0| 2|             
                                           | 9| 7| 2| 9| 8| 1| 0| 2| 2| 1| 0| 7| 8| 9| 1| 7| 9| 0| 2| 4| 9| 1| 0| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    VEHICLE                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Cardiomyopathy, Chronic              |                      2     2     2  2  2  2  2  2  2  2  2  2  2     2  1|             
      Coronary Artery, Inflammation,       |                                                                          |             
          Chronic Active                   |                                                                          |             
      Valve, Inflammation, Chronic Active  |                                                                         2|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |    3                                                                     |             
      Degeneration, Fatty                  |                      3                                               2   |             
      Hyperplasia                          |       2     1  2     2     2                    2                        |             
      Hypertrophy                          |                                                                          |             
      Necrosis                             |                                                                   1  2   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    3                                            2                       2|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  M  +  +  +  +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                     2        2                           |             
      Pars Distalis, Cyst                  |    X                                                                 X   |             
      Pars Distalis, Hyperplasia           |       2              2           2  2     1     2  2  2  2           2   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Cyst                                 |                      X                                                   |             
      C-Cell, Hyperplasia                  |    1        1  2  2        2              2     2  2  2  2     2     2   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Hyperplasia                          |                                           2                              |             
      Inflammation, Chronic Active         |                                        1              1                  |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                 X                        |             
                                            __________________________________________________________________________|             
   Oviduct                                 | +  +  +  +     +  +  +     +        +  +  +     +  +  +  +     +     +  +|             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                        3                             4   |             
      Endometrium, Hyperplasia, Cystic,    |                                                                          |             
           Glandular                       |                   3                    1  1              1           2   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |       +  +  +  +  +  +     +  +        +  +     +  +  +  +     +  +      |             
      Lymphopenia                          |                                                                   X      |             
      Neutropenia                          |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:22:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 7| 1| 6| 7| 7| 7| 4| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 3| 7| 2| 7| 7|             
                             DAY ON TEST   | 1| 5| 3| 8| 1| 3| 3| 3| 8| 3| 3| 3| 2| 2| 3| 3| 2| 3| 3| 1| 6| 3| 0| 0| 2|             
                                           | 9| 7| 2| 9| 8| 1| 0| 2| 2| 1| 0| 7| 8| 9| 1| 7| 9| 0| 2| 4| 9| 1| 0| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    VEHICLE                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Neutrophilia                         |                               X                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femoral, Atrophy                     |                                                                   4      |             
      Femoral, Hyperplasia                 |    3                       3  4     3                    2           3   |             
      Femoral, Hyperplasia, Reticulum Cell |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mediastinal, Necrosis                |                                                                   4      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Plasma Cell             |                                              2                           |             
      Infiltration Cellular, Histiocyte    |                                              2                           |             
      Necrosis                             |                                                                   4      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                                     +                    +        +     +|             
      Edema                                |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
      Necrosis                             |                                                                   3      |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Lymphoid                   |                                                                   2      |             
      Fibrosis                             |                                                                   3      |             
      Hematopoietic Cell Proliferation     | 2  2  2  2  2  1  2  2  2  2  4  1     2  2  2  2  2  2     2        2  2|             
      Necrosis                             |                                                                   4      |             
      Pigmentation, Hemosiderin            | 2     2  2  2  2  2  2  2  1     2     1  2  2  2  2  2     2           1|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  M  +  +  +  +  M  +  +  +  M  M  +  +  +  +  M  +  +  +  +  +  +  +|             
      Depletion Lymphoid                   |                                                                   4      |             
      Necrosis                             |          2                                                               |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  | 2                 3  2  2  2  2     3  2  2        3     2     2     3  2|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                               4                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                                                          |             
      Hydrocephalus                        |             2                                                            |             
      Thrombosis                           |                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                   +      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:22:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 7| 1| 6| 7| 7| 7| 4| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 3| 7| 2| 7| 7|             
                             DAY ON TEST   | 1| 5| 3| 8| 1| 3| 3| 3| 8| 3| 3| 3| 2| 2| 3| 3| 2| 3| 3| 1| 6| 3| 0| 0| 2|             
                                           | 9| 7| 2| 9| 8| 1| 0| 2| 2| 1| 0| 7| 8| 9| 1| 7| 9| 0| 2| 4| 9| 1| 0| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    VEHICLE                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |          +                                                  +     +      |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage, Acute                    |                                                                   2      |             
      Inflammation, Chronic Active         |          4                                2                              |             
      Alveolar Epithelium, Hyperplasia     | 2                                                                        |             
      Mediastinum, Inflammation, Chronic   |                                                                          |             
          Active                           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |          2                                                               |             
      Inflammation, Chronic Active         |          3     2                                                         |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                +  +        +           +  +  +                           |             
      Inflammation, Chronic                |                                              4                           |             
      Lens, Cataract                       |                3  3        3           3  3                              |             
      Retina, Atrophy                      |                3  3        3           3  3                              |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  M  +  +  +  M  +  +  M  +  M  +  +  +  +  +  +  M  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy, Chronic                 |    1  2     2  2  2  2  2  1  1        1  1  1  2  1  1  1     2  1  2  1|             
      Renal Tubule, Pigmentation,          |                                                                          |             
          Hemosiderin                      | 1  1  1     1  1  1  1  1  2  2     2  1  1  1  1  1  1  1  1  2     2  1|             
                                            __________________________________________________________________________|             
   Ureter                                  | +        +  +     +  +     +     +  +     +  +           +           +   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:22:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 6| 7| 6| 6| 7| 5| 5| 7| 7| 7| 7| 7| 4| 7| 7| 7| 6| 7| 2| 0| 7| 7|            |
                             DAY ON TEST   | 3| 0| 2| 6| 3| 1| 3| 2| 4| 2| 3| 3| 3| 3| 2| 0| 3| 3| 3| 5| 3| 0| 8| 3| 3|            |
                                           | 0| 5| 9| 2| 1| 2| 0| 9| 4| 9| 0| 2| 2| 2| 9| 0| 2| 0| 2| 8| 2| 9| 0| 0| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|      A     |
    VEHICLE                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Foreign Body                         |                   4                          4                           |      6  3.8|
      Inflammation, Chronic Active         |                                                                   2      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  A  +  +  +  A  +  A  +  +  +|  40        |
      Parasite Metazoan                    |                   X                                                      |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Parasite Metazoan                    |                      X                    X                              |      4     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +|  45        |
      Parasite Metazoan                    |                               X     X              X                     |      3     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  A  +  +  +|  40        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +|  43        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     | X  X  X  X  X  X  X  X  X     X  X  X  X  X  X  X  X  X     X        X  X|     38     |
      Degeneration, Fatty                  |                                                                          |      1  4.0|
      Fibrosis                             |                                                                          |      1  2.0|
      Hepatodiaphragmatic Nodule           |                                  X                 X                 X  X|      5     |
      Inflammation, Chronic                | 1  1  2  2  2  3  3  2        1  1  2  2  1  2  1     2           1  2  2|     32  1.7|
      Inflammation, Necrotizing            |                                                                          |      1  2.0|
      Vacuolization Cytoplasmic            |                            3                             2               |      3  2.3|
      Bile Duct, Hyperplasia               |                      1        1                 1           1           1|      8  1.4|
                                            __________________________________________________________________________|____________|
   Mesentery                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acinus, Atrophy                      | 2              2     1                 1  2        1                     |     13  1.5|
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                                                   +      |   1        |
      Inflammation, Chronic Active         |                                                                   2      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acanthosis                           |                                                                          |      1  3.0|
      Hyperkeratosis                       |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |    2                                                                     |      1  2.0|
      Necrosis, Coagulative                |                            2                                             |      1  2.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                   +      |   3        |
                                            __________________________________________________________________________|____________|
   Tooth                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   6                                                               
NTP Experiment-Test: 05020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:22:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 6| 7| 6| 6| 7| 5| 5| 7| 7| 7| 7| 7| 4| 7| 7| 7| 6| 7| 2| 0| 7| 7|            |
                             DAY ON TEST   | 3| 0| 2| 6| 3| 1| 3| 2| 4| 2| 3| 3| 3| 3| 2| 0| 3| 3| 3| 5| 3| 0| 8| 3| 3|            |
                                           | 0| 5| 9| 2| 1| 2| 0| 9| 4| 9| 0| 2| 2| 2| 9| 0| 2| 0| 2| 8| 2| 9| 0| 0| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|      A     |
    VEHICLE                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic Active         |                                                       2                  |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy, Chronic              | 2  2  2  2  2  1  2  2  1           2  1  2  1  2  2  2     2            |     32  1.8|
      Coronary Artery, Inflammation,       |                                                                          |            |
          Chronic Active                   |                                                                      4   |      1  4.0|
      Valve, Inflammation, Chronic Active  |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                         2                                                |      2  2.5|
      Degeneration, Fatty                  |                            2                          2                  |      4  2.3|
      Hyperplasia                          |    2        1        2        1        2        2                       1|     13  1.7|
      Hypertrophy                          |                                                          1               |      1  1.0|
      Necrosis                             |                3                                                         |      3  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                         3                                                |      4  2.5|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +|  42        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Angiectasis           |                                                                          |      2  2.0|
      Pars Distalis, Cyst                  |                                                                          |      2     |
      Pars Distalis, Hyperplasia           |                      2  2              2        2  3     2           2   |     17  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cyst                                 |                                                                          |      1     |
      C-Cell, Hyperplasia                  | 2  1  2     1        1        2  2  1  1  2     1     2                 2|     25  1.7|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +|  45        |
      Hyperplasia                          |                                                             2            |      2  2.0|
      Inflammation, Chronic Active         |                      1                    2        1     1  1           1|      8  1.1|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |    X                    X                                            X   |      4     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   7                                                               
NTP Experiment-Test: 05020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:22:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 6| 7| 6| 6| 7| 5| 5| 7| 7| 7| 7| 7| 4| 7| 7| 7| 6| 7| 2| 0| 7| 7|            |
                             DAY ON TEST   | 3| 0| 2| 6| 3| 1| 3| 2| 4| 2| 3| 3| 3| 3| 2| 0| 3| 3| 3| 5| 3| 0| 8| 3| 3|            |
                                           | 0| 5| 9| 2| 1| 2| 0| 9| 4| 9| 0| 2| 2| 2| 9| 0| 2| 0| 2| 8| 2| 9| 0| 0| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|      A     |
    VEHICLE                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Oviduct                                 | +  M  +  +  +  M  M  +  M  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|  38        |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Dilatation                           |                                                                          |      2  3.5|
      Endometrium, Hyperplasia, Cystic,    |                                                                          |            |
           Glandular                       |                                        1              2     1        2   |      9  1.6|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   | +     +     +        +     +  +  +  +  +  +     +  +  +     +        +  +|  32        |
      Lymphopenia                          |                                                                          |      1     |
      Neutropenia                          |                                                                          |      1     |
      Neutrophilia                         |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Femoral, Atrophy                     |                                                                          |      1  4.0|
      Femoral, Hyperplasia                 |          3  2     2  2                                   4               |     11  2.8|
      Femoral, Hyperplasia, Reticulum Cell |                                                    3                     |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mediastinal, Necrosis                |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hemorrhage                           |                                                                   3      |      1  3.0|
      Hyperplasia, Plasma Cell             |                                                                          |      1  2.0|
      Infiltration Cellular, Histiocyte    |                                                                          |      1  2.0|
      Necrosis                             |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                   +                                   +        +         |   7        |
      Edema                                |                   2                                   2                  |      2  2.0|
      Hemorrhage                           |                   2                                                      |      1  2.0|
      Infiltration Cellular, Histiocyte    |                   2                                                      |      1  2.0|
      Necrosis                             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Depletion Lymphoid                   |                                                                          |      1  2.0|
      Fibrosis                             |                                                                          |      1  3.0|
      Hematopoietic Cell Proliferation     | 2  2  2     3  1  2  2  2     2  1  2  2  2     1  3  1     2     2  2  2|     41  2.0|
      Necrosis                             |                                                                          |      1  4.0|
      Pigmentation, Hemosiderin            | 2  2  2  2  2  2     2        2  2  2  2  2  2  2  2  2     3  2  2  2  2|     39  1.9|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  42        |
      Depletion Lymphoid                   |                                                                          |      1  4.0|
      Necrosis                             |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   8                                                               
NTP Experiment-Test: 05020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:22:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 6| 7| 6| 6| 7| 5| 5| 7| 7| 7| 7| 7| 4| 7| 7| 7| 6| 7| 2| 0| 7| 7|            |
                             DAY ON TEST   | 3| 0| 2| 6| 3| 1| 3| 2| 4| 2| 3| 3| 3| 3| 2| 0| 3| 3| 3| 5| 3| 0| 8| 3| 3|            |
                                           | 0| 5| 9| 2| 1| 2| 0| 9| 4| 9| 0| 2| 2| 2| 9| 0| 2| 0| 2| 8| 2| 9| 0| 0| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|      A     |
    VEHICLE                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia, Cystic                  | 3  2  4  3     2  2  2     2  2  2  2  2  2     2  3  2  2  2        2  3|     34  2.3|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Chronic Active         |                                     1                                    |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          |          X  X  X  X                                                      |      4     |
      Hydrocephalus                        |    2              2                                                      |      3  2.0|
      Thrombosis                           | X                                                                        |      1     |
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                                              +                 +         |   3        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                              +                 +         |   5        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hemorrhage, Acute                    |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |                   2                 2                                1   |      5  2.2|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      1  2.0|
      Mediastinum, Inflammation, Chronic   |                                                                          |            |
          Active                           |                                                                   3      |      1  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Foreign Body                         |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |                                  2                                       |      3  2.3|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |                                                       1     2            |      2  1.5|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     | +     +     +              +                    +  +                     |  12        |
      Inflammation, Chronic                |                                                                          |      1  4.0|
      Lens, Cataract                       | 3     3     3                                   3  3                     |     10  3.0|
      Retina, Atrophy                      | 3     3     3              2                    3  3                     |     11  2.9|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  M  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  42        |
      Inflammation, Chronic                |                                                                   2      |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   9                                                               
NTP Experiment-Test: 05020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:22:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 6| 7| 6| 6| 7| 5| 5| 7| 7| 7| 7| 7| 4| 7| 7| 7| 6| 7| 2| 0| 7| 7|            |
                             DAY ON TEST   | 3| 0| 2| 6| 3| 1| 3| 2| 4| 2| 3| 3| 3| 3| 2| 0| 3| 3| 3| 5| 3| 0| 8| 3| 3|            |
                                           | 0| 5| 9| 2| 1| 2| 0| 9| 4| 9| 0| 2| 2| 2| 9| 0| 2| 0| 2| 8| 2| 9| 0| 0| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|      A     |
    VEHICLE                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Nephropathy, Chronic                 | 2  2  2  2  1     1  1        1  2  1  1  2     2  3  2  1  2        2  3|     39  1.6|
      Renal Tubule, Pigmentation,          |                                                                          |            |
          Hemosiderin                      | 1  1  1  2  1     1  1  2  2  1  1  1  1  1  1  1  1  1  1  1        1  1|     44  1.2|
                                            __________________________________________________________________________|____________|
   Ureter                                  |          +           +           +                 +                    +|  17        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  10                                                               
NTP Experiment-Test: 05020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:22:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 1| 7| 7|             
                             DAY ON TEST   | 2| 2| 3| 0| 3| 3| 3| 2| 6| 2| 2| 3| 3| 3| 3| 3| 3| 3| 8| 2| 3| 2| 4| 1| 3|             
                                           | 9| 9| 1| 5| 2| 0| 0| 3| 4| 9| 9| 0| 2| 1| 1| 0| 2| 1| 8| 9| 1| 9| 0| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    2 MG/KG                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |          +                                                        +  +   |             
      Foreign Body                         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         |          +                                                        +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |          +                                                        M      |             
      Inflammation, Chronic Active         |                                                                          |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |          +                                                        +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |          +                                                        M      |             
                                            __________________________________________________________________________|             
   Intestine Small                         |          +                                                        +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |          +                                                        M      |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |          +                                                        M      |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |          +                                                        +      |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | X  X  X  X  X  X  X  X     X     X  X  X  X  X  X  X  X  X  X  X     X  X|             
      Clear Cell Focus                     |                                                    X                     |             
      Degeneration, Cystic                 |                                                                1         |             
      Hepatodiaphragmatic Nodule           |                               X                                          |             
      Inflammation, Chronic                | 2           2  2  1  1  1  2        2  1  1  1  2  2     1     1     2  1|             
      Inflammation, Necrotizing            |                                                                          |             
      Vacuolization Cytoplasmic            |                                     2                                    |             
      Bile Duct, Hyperplasia               | 1  1                                                                     |             
                                            __________________________________________________________________________|             
   Mesentery                               |          +                                                     +  +      |             
      Inflammation, Chronic                |                                                                3         |             
      Necrosis                             |                                                                4         |             
                                            __________________________________________________________________________|             
   Pancreas                                |          +                                                        +      |             
      Acinus, Atrophy                      |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |          +           +  +                                         +  +   |             
                                            __________________________________________________________________________|             
   Stomach                                 |          +                                                        +      |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |          +                                                        +      |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |          +                                                        +      |             
      Necrosis, Coagulative                |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |          +                                                               |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |          +                                                        +  +   |             
                                            __________________________________________________________________________|             
   Heart                                   |          +                                                        +  +   |             
      Cardiomyopathy, Chronic              |                                                                      2   |             
      Coronary Artery, Inflammation,       |                                                                          |             
          Chronic Active                   |                                                                          |             
      Endocardium, Proliferation           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  11                                                               
NTP Experiment-Test: 05020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:22:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 1| 7| 7|             
                             DAY ON TEST   | 2| 2| 3| 0| 3| 3| 3| 2| 6| 2| 2| 3| 3| 3| 3| 3| 3| 3| 8| 2| 3| 2| 4| 1| 3|             
                                           | 9| 9| 1| 5| 2| 0| 0| 3| 4| 9| 9| 0| 2| 1| 1| 0| 2| 1| 8| 9| 1| 9| 0| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    2 MG/KG                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                               X                                          |             
      Degeneration, Fatty                  |    2                 1        1                          2           2   |             
      Hyperplasia                          |    2  2     2        2        2  1     2                 2           2   |             
      Hypertrophy                          |                               2                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       2           2                                                     1|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |          +                                                        +      |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |          +                                                        +      |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +        +        +  +  +  +        +  +  +  +     +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                               4                                          |             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia           |                   3        2  2     2        2     2  2        2        2|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |          +                                                        +      |             
      C-Cell, Hyperplasia                  |          2                                                               |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |          M                                                  +     M      |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic Active         |                                                             2            |             
                                            __________________________________________________________________________|             
   Ovary                                   |          +  +                       +        +     +              +      |             
                                            __________________________________________________________________________|             
   Oviduct                                 |                                     +        +     +              +      |             
                                            __________________________________________________________________________|             
   Uterus                                  |    +     +                    +                                   +      |             
      Dilatation                           |    4                                                                     |             
      Inflammation, Chronic Active         |    3                                                                     |             
      Endometrium, Hyperplasia, Cystic,    |                                                                          |             
           Glandular                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +        +|             
      Neutrophilia                         |                      X                                                   |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +     +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +|             
      Femoral, Atrophy                     |                                                                          |             
      Femoral, Hemorrhage, Acute           |                                                                          |             
      Femoral, Hyperplasia                 |          3           4                                               3   |             
      Femoral, Hyperplasia, Reticulum Cell |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |          +           +  +                                         +  +   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |          +              +                                         +  +   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                                                                      M   |             
      Cyst                                 |                                                                          |             
      Ectasia                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  12                                                               
NTP Experiment-Test: 05020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:22:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 1| 7| 7|             
                             DAY ON TEST   | 2| 2| 3| 0| 3| 3| 3| 2| 6| 2| 2| 3| 3| 3| 3| 3| 3| 3| 8| 2| 3| 2| 4| 1| 3|             
                                           | 9| 9| 1| 5| 2| 0| 0| 3| 4| 9| 9| 0| 2| 1| 1| 0| 2| 1| 8| 9| 1| 9| 0| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    2 MG/KG                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                        2                                 |             
      Hematopoietic Cell Proliferation     | 2  2  2  2  2  2  2  2  2  2  2  1  2  2  2  2  2  2  4  2  3  2  2  2  2|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Pigmentation, Hemosiderin            | 2  2  3  1  3  3  2  2  2  2  2  2  2  2  3  2  2  3  2  2  2  2  2  2  2|             
                                            __________________________________________________________________________|             
   Thymus                                  |          +                                                        +  +   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |          +                    +                             +     M      |             
      Hyperplasia, Cystic                  |          1                                                  3            |             
                                            __________________________________________________________________________|             
   Skin                                    |       +  +           +        +                       +     +     +      |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +     +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |          +                                                        +      |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |          +                                                        +      |             
      Compression                          |                                                                          |             
      Hydrocephalus                        |                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |          +                                                        +      |             
                                            __________________________________________________________________________|             
   Nose                                    |          +                                                        M      |             
                                            __________________________________________________________________________|             
   Trachea                                 |          +                                                        M  +   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     | +  +  +     +  +  +  +     +  +           +           +        +         |             
      Cornea, Inflammation, Chronic        |                                                                2         |             
      Lens, Cataract                       | 3  3  3     3  3  3  3     3  3           3                    3         |             
      Retina, Atrophy                      | 3  3  3     3  3  3  3     3  3           3           3        3         |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |          +                                                               |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                      +                                                   |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy, Chronic                 | 2  2  3  1  2  2  2  2  2        2  2  3  2  1  3        1  1  2     2  2|             
      Renal Tubule, Pigmentation,          |                                                                          |             
          Hemosiderin                      | 1  2  1  2  1  1  1  1  1  2  2  2  2  2  2  1  2  2  2  2  2  2     1  2|             
                                            __________________________________________________________________________|             
   Ureter                                  |    +                          +                 +           +  +     +   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |          +                                                        +      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  13                                                               
NTP Experiment-Test: 05020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:22:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 0| 2| 2| 1| 3| 2| 3| 9| 3| 3| 2| 3| 2| 2| 2|            |
                                           | 0| 0| 1| 1| 0| 2| 9| 0| 1| 2| 5| 9| 9| 7| 0| 9| 2| 3| 0| 0| 9| 0| 8| 8| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|      A     |
    2 MG/KG                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |                               +        +           +              +  +   |   8        |
      Foreign Body                         |                                                    3                     |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         |                      +        +        +                          +  +   |   7        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                      +        +        +                             A   |   4        |
      Inflammation, Chronic Active         |                      4                                                   |      1  4.0|
      Parasite Metazoan                    |                      X                                                   |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                               +        +                          +  +   |   6        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                               +        +                             A   |   3        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                               +        +                             +   |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                               +        +                             A   |   3        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                               +        +                             A   |   3        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                               +        +                             +   |   5        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     | X  X  X  X  X  X  X  X  X  X  X  X  X     X  X  X  X  X  X  X  X     X  X|     45     |
      Clear Cell Focus                     |                                                                          |      1     |
      Degeneration, Cystic                 |                                                                          |      1  1.0|
      Hepatodiaphragmatic Nodule           |                X                                                         |      2     |
      Inflammation, Chronic                | 2  2           2  1  2  2  2     2  1     1           3     2  2         |     30  1.6|
      Inflammation, Necrotizing            |       1                                                                  |      1  1.0|
      Vacuolization Cytoplasmic            |                            1           3                                 |      3  2.0|
      Bile Duct, Hyperplasia               |                   1                                                      |      3  1.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               | +                             +        +                          +      |   7        |
      Inflammation, Chronic                | 4                                                                        |      2  3.5|
      Necrosis                             | 4                                                                        |      2  4.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                |                               +        +                          +  +   |   6        |
      Acinus, Atrophy                      |                               1                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                               +        +                             +   |   8        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |                               +        +                             +   |   5        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                               +        +                             +   |   5        |
      Inflammation, Chronic Active         |                                        2                                 |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                               +        +                             A   |   4        |
      Necrosis, Coagulative                |                                        3                                 |      1  3.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                               +        +                             +   |   4        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |    +                          +        +                          +  +   |   8        |
                                            __________________________________________________________________________|____________|
   Heart                                   |                               +        +                    +        +   |   7        |
      Cardiomyopathy, Chronic              |                                                                      2   |      2  2.0|
      Coronary Artery, Inflammation,       |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  14                                                               
NTP Experiment-Test: 05020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:22:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 0| 2| 2| 1| 3| 2| 3| 9| 3| 3| 2| 3| 2| 2| 2|            |
                                           | 0| 0| 1| 1| 0| 2| 9| 0| 1| 2| 5| 9| 9| 7| 0| 9| 2| 3| 0| 0| 9| 0| 8| 8| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|      A     |
    2 MG/KG                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
          Chronic Active                   |                                                                      2   |      1  2.0|
      Endocardium, Proliferation           |                                                             4            |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                                          |      1     |
      Degeneration, Fatty                  |    1     1     1                       2                 2               |     10  1.5|
      Hyperplasia                          |       2  1  2  2  1  2           2        1     2  2     2  1  2        2|     23  1.8|
      Hypertrophy                          |                         2                                                |      2  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                         2                                                |      4  1.8|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                               +        +                             +   |   5        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                               +        +                             M   |   4        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |       +  +  +     +  +     +  +        +  +  +     +  +  +        +  +   |  33        |
      Pars Distalis, Angiectasis           |                                                                          |      1  4.0|
      Pars Distalis, Cyst                  |          X                                X              X               |      3     |
      Pars Distalis, Hyperplasia           |       2  2  3     3  2     2                          2  2        2      |     18  2.2|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                               +        +           +                 +   |   6        |
      C-Cell, Hyperplasia                  |                               1        2                                 |      3  1.7|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |                               +        M                 +        +  +   |   5        |
      Hyperplasia                          |                                                                   2      |      1  2.0|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   |    +     +     +              +  +     +                    +  +     +   |  15        |
                                            __________________________________________________________________________|____________|
   Oviduct                                 |    +     +     +                 +                          +  +         |  10        |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +     +        M           +  +  +     +  +        +              +  +   |  14        |
      Dilatation                           |                            3                                             |      2  3.5|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Endometrium, Hyperplasia, Cystic,    |                                                                          |            |
           Glandular                       |                                        2                                 |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +|  45        |
      Neutrophilia                         |    X                                                                     |      2     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  15                                                               
NTP Experiment-Test: 05020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:22:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 0| 2| 2| 1| 3| 2| 3| 9| 3| 3| 2| 3| 2| 2| 2|            |
                                           | 0| 0| 1| 1| 0| 2| 9| 0| 1| 2| 5| 9| 9| 7| 0| 9| 2| 3| 0| 0| 9| 0| 8| 8| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|      A     |
    2 MG/KG                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Femoral, Atrophy                     |                                                                   4      |      1  4.0|
      Femoral, Hemorrhage, Acute           |                                                                   4      |      1  4.0|
      Femoral, Hyperplasia                 |    4           2     4  3           2  3              2  4     2         |     12  3.0|
      Femoral, Hyperplasia, Reticulum Cell |                         2                                      2         |      2  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +                 +        +        +                 +        +  +   |  12        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                               +        +                             +   |   7        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                      +                 +                 +        +      |   4        |
      Cyst                                 |                      X                                                   |      1     |
      Ectasia                              |                      2                                                   |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             |                   3                                                      |      2  2.5|
      Hematopoietic Cell Proliferation     | 2  2  2  2  2  2  2  3  2  2  3  2  2     2  2  2  2  2  4  2  2     2  2|     48  2.1|
      Hyperplasia, Lymphoid                |                      3                                                   |      1  3.0|
      Pigmentation, Hemosiderin            | 2  1  3  2  2  2  2  1  2  2  3  2  2     2  3  2  3  2  1  3  2  1  3  1|     49  2.1|
                                            __________________________________________________________________________|____________|
   Thymus                                  |    +                          +        +                          +  +   |   8        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |    +        +  +     +  +     +        +     +  +     +  +        +  +  +|  17        |
      Hyperplasia, Cystic                  |             2  2        2     3        2     2           2        3  2   |     11  2.2|
                                            __________________________________________________________________________|____________|
   Skin                                    |    +        +  +     +  +     +        +     +  +  +  +              +  +|  20        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                               +        +                             +   |   5        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                               +        +                             +   |   5        |
      Compression                          |                               X                                          |      1     |
      Hydrocephalus                        |                               4                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                      +   |   1        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                      +   |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |                               +        +                             +   |   5        |
                                            __________________________________________________________________________|____________|
   Nose                                    |                               +        +                             +   |   4        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |    +                          +        +           +              +  +   |   8        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  16                                                               
NTP Experiment-Test: 05020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:22:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 0| 2| 2| 1| 3| 2| 3| 9| 3| 3| 2| 3| 2| 2| 2|            |
                                           | 0| 0| 1| 1| 0| 2| 9| 0| 1| 2| 5| 9| 9| 7| 0| 9| 2| 3| 0| 0| 9| 0| 8| 8| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|      A     |
    2 MG/KG                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     | +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +  +  +         |  32        |
      Cornea, Inflammation, Chronic        |                                                                          |      1  2.0|
      Lens, Cataract                       | 3  3  3  3  3  3  3     3  3     3     2  3  3  3  3  3  3  3  3         |     30  3.0|
      Retina, Atrophy                      | 3  3  3  3  3  3  3  3  3  3     3     3  3  3  3  3  3  3  3  3         |     32  3.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |             +                 +        +  +                          +   |   6        |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                              +                           |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Nephropathy, Chronic                 | 2     1  1  2  1  2        1  2  2     1  1  1  1  2  1  2  1  1        1|     39  1.7|
      Renal Tubule, Pigmentation,          |                                                                          |            |
          Hemosiderin                      | 2  1  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  3     2|     48  1.8|
                                            __________________________________________________________________________|____________|
   Ureter                                  |                               +        +           +  +        +     +   |  12        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                               +        +                             +   |   5        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  17                                                               
NTP Experiment-Test: 05020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:22:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 7| 3| 3| 3| 3| 2| 3| 4| 3| 1| 3| 3| 3| 3| 3| 3| 9| 0| 2| 3| 3| 3| 0|             
                                           | 0| 1| 7| 2| 0| 0| 2| 9| 0| 4| 2| 9| 0| 2| 1| 2| 0| 1| 5| 5| 9| 1| 2| 1| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    18 MG/KG                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Inflammation, Chronic Active         |                                  2                                       |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Parasite Metazoan                    | X                                                                        |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | X  X  X  X     X  X  X  X     X  X  X  X  X  X  X     X  X  X  X  X  X   |             
      Clear Cell Focus                     | X                                                                        |             
      Hepatodiaphragmatic Nodule           |                                                             X            |             
      Inflammation, Chronic                | 1     2  1     2  1  1        1     2  2  3  1  1  2     2     1  3  2   |             
      Inflammation, Necrotizing            |                                                                          |             
      Necrosis, Coagulative                |                                                                         3|             
      Pigmentation, Hemosiderin            |                                                                          |             
      Vacuolization Cytoplasmic            |                                                                   3      |             
      Bile Duct, Hyperplasia               |             1           1           1           1                        |             
                                            __________________________________________________________________________|             
   Mesentery                               | +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
      Inflammation, Chronic                |                                  4     1                                 |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectopic Tissue                       |                   X                                                      |             
      Inflammation, Chronic                |          1                       4                                       |             
      Acinus, Atrophy                      | 1              1  1                                2           1  1  2   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                  3                                       |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Inflammation, Chronic Active         |                                  3                                4      |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Inflammation, Chronic Active         |                                  3                                       |             
                                            __________________________________________________________________________|             
   Tooth                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Mesenteric Artery, Inflammation,     |                                                                          |             
           Chronic Active                  |                                  4                                3      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  18                                                               
NTP Experiment-Test: 05020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:22:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 7| 3| 3| 3| 3| 2| 3| 4| 3| 1| 3| 3| 3| 3| 3| 3| 9| 0| 2| 3| 3| 3| 0|             
                                           | 0| 1| 7| 2| 0| 0| 2| 9| 0| 4| 2| 9| 0| 2| 1| 2| 0| 1| 5| 5| 9| 1| 2| 1| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    18 MG/KG                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy, Chronic              | 2  1  1  2  2  2     2  2  2  2  1  2  2  2  2     2  2  2  2  2  2  2  2|             
      Inflammation, Chronic Active         |                                  2                                       |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Fatty                  | 1                 1     2              2  1     2                    1   |             
      Hyperplasia                          | 2              2  1     3  2     2        2  2                       2   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2              2     2        2  2  1  2  1  1  2  1  2     1  2        1|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  | X              X  X              X                 X        X  X         |             
      Pars Distalis, Degeneration, Cystic  |                                                                          |             
      Pars Distalis, Hyperplasia           | 2        2  2        2        2  2     2  2  2        2     1           1|             
      Pars Distalis, Inflammation, Chronic |                                                                          |             
      Pars Nervosa, Hyperplasia, Glandular |                                  2                                       |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Inflammation, Chronic Active         |                                  2                                       |             
      C-Cell, Hyperplasia                  |    1     1  1  2  2  2  1     2  1  2  2  2  2  1  2  2     1  1  1  1   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    2                                2                                    |             
      Inflammation, Chronic Active         | 2                                         2                 1  3  2      |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |          X           X                                                   |             
                                            __________________________________________________________________________|             
   Oviduct                                 |    +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |          3                             4        3                        |             
      Hemorrhage, Chronic                  |                                        4                                 |             
      Inflammation, Chronic Active         |          3                                                               |             
      Endometrium, Hyperplasia, Cystic,    |                                                                          |             
           Glandular                       |             2                                                        2   |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                       +                  |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   | +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +   |             
      Neutrophilia                         |          X                                                               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  19                                                               
NTP Experiment-Test: 05020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:22:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 7| 3| 3| 3| 3| 2| 3| 4| 3| 1| 3| 3| 3| 3| 3| 3| 9| 0| 2| 3| 3| 3| 0|             
                                           | 0| 1| 7| 2| 0| 0| 2| 9| 0| 4| 2| 9| 0| 2| 1| 2| 0| 1| 5| 5| 9| 1| 2| 1| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    18 MG/KG                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  I  +  +  +  A  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Femoral, Hyperplasia                 | 2  2  4  3           2  2     2  4     2  3        3  4  3  2  3     2  3|             
      Femoral, Hyperplasia, Re Cell        |             3                          2                       2         |             
      Femoral, Hyperplasia, Reticulum Cell |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bronchial, Pigmentation, Hemosiderin |    2                                                                     |             
      Mediastinal, Cyst                    |                                              X                           |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Histiocyte                      |       3                                                                  |             
      Pancreatic, Pigmentation, Hemosiderin|                      3                                                   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                 X                    X   |             
      Hyperplasia, Plasma Cell             |                                  2                                       |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                                  +     +                    +  +  +     +|             
      Hyperplasia, Lymphoid                |                                  2                                       |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Fibrosis                             | 2  2     2  3  2  2  2  2     4        3  2  2  2  3     2  2  2  3  2  2|             
      Hematopoietic Cell Proliferation     | 2     2     2     2  2  1        3  1  2  1  3  1  1  4  3  1        1   |             
      Infiltration Cellular, Lipocyte      | 1        2                             3                 3               |             
      Inflammation, Chronic Active         |                                  4                                       |             
      Pigmentation, Hemosiderin            | 2  2  2  2  2  2  2  2  2  2  2  3  2  2  2  2  2  3     1  2  2  2  2   |             
      Capsule, Cyst                        |                                              X                           |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  M|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  | 2  2  2  2  1  3  2  3  3  4  4  2  3  3  4  2  2  2  2  4  3  4  4  2  3|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                  2                                       |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                     X                             X      |             
      Hydrocephalus                        |                                                                   2      |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granuloma                            |                                                                          |             
      Inflammation, Chronic Active         |                2                                                         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  20                                                               
NTP Experiment-Test: 05020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:22:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 7| 3| 3| 3| 3| 2| 3| 4| 3| 1| 3| 3| 3| 3| 3| 3| 9| 0| 2| 3| 3| 3| 0|             
                                           | 0| 1| 7| 2| 0| 0| 2| 9| 0| 4| 2| 9| 0| 2| 1| 2| 0| 1| 5| 5| 9| 1| 2| 1| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    18 MG/KG                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |          2                                   4                           |             
      Mediastinum, Inflammation, Chronic   |                                                                          |             
          Active                           |                                  3                                       |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                         2     2        2  2  2     2                     |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic Active                  |                                                 2              2         |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |    2           1     2                                                   |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |          +  +     +     +        +  +  +  +  +  +  +        +  +  +  +   |             
      Inflammation, Chronic                |                                                                          |             
      Anterior Chamber, Inflammation,      |                                                                          |             
          Suppurative                      |                                                                          |             
      Lens, Cataract                       |          3  3     3     3        2  3  3  3  3  3  3        3  3  3  3   |             
      Retina, Atrophy                      |          3  3     3     3        3  3  3  3  3  3  3        3  3  3  3   |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +|             
      Atrophy                              |       2                                                                  |             
      Inflammation, Chronic                |                               2        2                                 |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                X                                                         |             
      Inflammation, Chronic Active         |                                  2                                       |             
      Nephropathy, Chronic                 | 1  2     1  1  1  1  1  1     1     1  2  1  2  2  1     1  1  1  3  2  2|             
      Renal Tubule, Pigmentation,          |                                                                          |             
          Hemosiderin                      | 3  3  2  3  3  3  3  3  3  3  3  3  3  3  3  3  3  3  3  3  3  3  3  3  3|             
                                            __________________________________________________________________________|             
   Ureter                                  |          +                    +     +     +              +  +  +         |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Inflammation, Chronic Active         |                                  3                                       |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  21                                                               
NTP Experiment-Test: 05020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:22:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 5| 6| 6| 7| 7| 6| 7| 7| 5|            |
                             DAY ON TEST   | 2| 3| 3| 2| 3| 3| 2| 3| 3| 1| 2| 3| 3| 3| 2| 3| 5| 8| 6| 3| 3| 1| 3| 3| 2|            |
                                           | 9| 2| 2| 6| 0| 0| 9| 0| 2| 1| 9| 2| 1| 1| 9| 1| 2| 8| 5| 1| 0| 6| 2| 1| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      A     |
    18 MG/KG                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +|  46        |
      Parasite Metazoan                    |       X                                                                  |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +|  46        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Parasite Metazoan                    |                               X           X        X                     |      3     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|  47        |
      Parasite Metazoan                    |    X                                                                     |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  A  +  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     | X  X  X     X  X  X  X  X  X  X  X  X  X  X  X  X  X     X  X  X  X  X  X|     44     |
      Clear Cell Focus                     |    X                                                     X               |      3     |
      Hepatodiaphragmatic Nodule           |                               X                          X               |      3     |
      Inflammation, Chronic                | 2  1  3  2  2     2  2  1  1  1  2  1  2     2     1     1  1     1  2   |     36  1.6|
      Inflammation, Necrotizing            |                                              2                           |      1  2.0|
      Necrosis, Coagulative                |                                                                          |      1  3.0|
      Pigmentation, Hemosiderin            |                                                       2                  |      1  2.0|
      Vacuolization Cytoplasmic            |                                                                          |      1  3.0|
      Bile Duct, Hyperplasia               | 1  1        1  1                                            1            |      9  1.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Inflammation, Chronic                | 2     2                             2              1        1        1   |      8  1.8|
      Necrosis                             | 4                                                                        |      1  4.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Ectopic Tissue                       |                                                                          |      1     |
      Inflammation, Chronic                |                                                                          |      2  2.5|
      Acinus, Atrophy                      |             2  1  1  1  2     1                    1              2      |     15  1.3|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Inflammation, Chronic Active         |                                                                          |      2  3.5|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |             2                                                            |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  22                                                               
NTP Experiment-Test: 05020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:22:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 5| 6| 6| 7| 7| 6| 7| 7| 5|            |
                             DAY ON TEST   | 2| 3| 3| 2| 3| 3| 2| 3| 3| 1| 2| 3| 3| 3| 2| 3| 5| 8| 6| 3| 3| 1| 3| 3| 2|            |
                                           | 9| 2| 2| 6| 0| 0| 9| 0| 2| 1| 9| 2| 1| 1| 9| 1| 2| 8| 5| 1| 0| 6| 2| 1| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      A     |
    18 MG/KG                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Mesenteric Artery, Inflammation,     |                                                                          |            |
           Chronic Active                  |                                                                          |      2  3.5|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy, Chronic              | 2     2     2  2  2  2  2  2     2  2  2  2  2     2  2  2  2  2  2  2  2|     44  1.9|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Degeneration, Fatty                  |                         2                    1        3  3               |     11  1.7|
      Hyperplasia                          | 2  2  2     2  2  2  2  3                 2  2                       2   |     20  2.1|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          | 2     2     2  2  1                       2                       1  2  2|     24  1.7|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  M  +  +  +  M  +  +  +  +|  42        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Cyst                  |       X                       X     X                    X  X            |     12     |
      Pars Distalis, Degeneration, Cystic  |                                                                         2|      1  2.0|
      Pars Distalis, Hyperplasia           |                         2              2  2                    2         |     16  1.9|
      Pars Distalis, Inflammation, Chronic |                                                                      2   |      1  2.0|
      Pars Nervosa, Hyperplasia, Glandular |                                                                         2|      2  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      C-Cell, Hyperplasia                  | 1  1  2     1  2  2  2  2     2  2  2     2  2     1  1  2  2     2  2   |     39  1.6|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hyperplasia                          | 2                                1           3                           |      5  2.0|
      Inflammation, Chronic Active         |                         2                    3                           |      7  2.1|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cyst                                 |                                                                X        X|      4     |
                                            __________________________________________________________________________|____________|
   Oviduct                                 | +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +  M  +  +  M|  42        |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  23                                                               
NTP Experiment-Test: 05020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:22:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 5| 6| 6| 7| 7| 6| 7| 7| 5|            |
                             DAY ON TEST   | 2| 3| 3| 2| 3| 3| 2| 3| 3| 1| 2| 3| 3| 3| 2| 3| 5| 8| 6| 3| 3| 1| 3| 3| 2|            |
                                           | 9| 2| 2| 6| 0| 0| 9| 0| 2| 1| 9| 2| 1| 1| 9| 1| 2| 8| 5| 1| 0| 6| 2| 1| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      A     |
    18 MG/KG                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Dilatation                           |                            3  3     2                                    |      6  3.0|
      Hemorrhage, Chronic                  |                                                                          |      1  4.0|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Endometrium, Hyperplasia, Cystic,    |                                                                          |            |
           Glandular                       |    2  2        1              2           3              1               |      8  1.9|
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +  +  +  +     +  +  +|  43        |
      Neutrophilia                         |                                  X           X                           |      3     |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Femoral, Hyperplasia                 | 3  3  2     2  3  4  2  2  2  4  2     2  2        3  4  4  3  4     2  4|     37  2.8|
      Femoral, Hyperplasia, Re Cell        |                                        4                                 |      4  2.8|
      Femoral, Hyperplasia, Reticulum Cell |       2     2     2              1  2              1                 2   |      7  1.7|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Bronchial, Pigmentation, Hemosiderin |                                                                          |      1  2.0|
      Mediastinal, Cyst                    |                                     X                                    |      2     |
      Mediastinal, Infiltration Cellular,  |                                                                          |            |
           Histiocyte                      |                                                 3                        |      2  3.0|
      Pancreatic, Pigmentation, Hemosiderin|                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cyst                                 |                                                                          |      2     |
      Hyperplasia, Plasma Cell             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |       +              +                                                  +|   9        |
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                     X                                    |      1     |
      Fibrosis                             | 3     3     2  3  3  2  2  2  3  3  3  2  2  2  2  2  4  3  3  2  3  2   |     42  2.4|
      Hematopoietic Cell Proliferation     | 2        2  2  2  2  1     2        3           3  4  2  4  2  3        4|     32  2.2|
      Infiltration Cellular, Lipocyte      | 2           2     2  2        2                             2        2   |     11  2.1|
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
      Pigmentation, Hemosiderin            | 2  1  2  3  2  3  3  2  2  2  2  2  2  1  2  2  2  2  2  1  1  2  2  2  2|     48  2.0|
      Capsule, Cyst                        |                      X                                         X         |      3     |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  M  +  +  +  +  +  +|  44        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Cystic                  | 3  1  2  3  2     4  2  2  2  1  4  2  2  3  2     2  3  4  2  2  3  2  2|     48  2.6|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  24                                                               
NTP Experiment-Test: 05020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:22:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 5| 6| 6| 7| 7| 6| 7| 7| 5|            |
                             DAY ON TEST   | 2| 3| 3| 2| 3| 3| 2| 3| 3| 1| 2| 3| 3| 3| 2| 3| 5| 8| 6| 3| 3| 1| 3| 3| 2|            |
                                           | 9| 2| 2| 6| 0| 0| 9| 0| 2| 1| 9| 2| 1| 1| 9| 1| 2| 8| 5| 1| 0| 6| 2| 1| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      A     |
    18 MG/KG                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          |          X     X                             X                           |      5     |
      Hydrocephalus                        |          3     2                             2                           |      4  2.3|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Granuloma                            |                                                                         1|      1  1.0|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      2  3.0|
      Mediastinum, Inflammation, Chronic   |                                                                          |            |
          Active                           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Chronic Active         |                               2  2  2  2  2                              |     11  2.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Chronic Active                  |                                                                          |      2  2.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |                                                    3                     |      4  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     | +           +  +  +  +  +     +  +  +     +        +  +  +  +     +  +   |  31        |
      Inflammation, Chronic                |                                                             4            |      1  4.0|
      Anterior Chamber, Inflammation,      |                                                                          |            |
          Suppurative                      |                                  2                                       |      1  2.0|
      Lens, Cataract                       | 3           3  3  3  3  3     3  3  3     3           3  3  3     3  3   |     30  3.0|
      Retina, Atrophy                      | 3           3  3  3  3  3     3  3  3     3        3  3  3  3     3  3   |     31  3.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M|  44        |
      Atrophy                              |                                                                          |      1  2.0|
      Inflammation, Chronic                |                               2  2           2  2                        |      6  2.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  25                                                               
NTP Experiment-Test: 05020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:22:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 5| 6| 6| 7| 7| 6| 7| 7| 5|            |
                             DAY ON TEST   | 2| 3| 3| 2| 3| 3| 2| 3| 3| 1| 2| 3| 3| 3| 2| 3| 5| 8| 6| 3| 3| 1| 3| 3| 2|            |
                                           | 9| 2| 2| 6| 0| 0| 9| 0| 2| 1| 9| 2| 1| 1| 9| 1| 2| 8| 5| 1| 0| 6| 2| 1| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      A     |
    18 MG/KG                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Cyst                                 |                                                                          |      1     |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Nephropathy, Chronic                 | 1  1  1     1  2  1  1  1  2  1  1  1  1  1  1     1     1  1     1  1   |     41  1.2|
      Renal Tubule, Pigmentation,          |                                                                          |            |
          Hemosiderin                      | 3  3  3  2  3  3  3  3  3  2  3  3  3  3  3  3  2  3  3  3  3  2  3  3  2|     50  2.9|
                                            __________________________________________________________________________|____________|
   Ureter                                  |       +                                               +                  |   9        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  26                                                               
NTP Experiment-Test: 05020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:22:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 5| 7| 7|             
                             DAY ON TEST   | 8| 1| 5| 3| 2| 3| 3| 2| 3| 0| 3| 3| 3| 7| 3| 3| 3| 3| 3| 5| 2| 3| 2| 2| 2|             
                                           | 1| 1| 7| 1| 9| 0| 1| 9| 1| 5| 0| 1| 1| 4| 0| 0| 2| 0| 1| 3| 1| 2| 0| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    6 MG/KG                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +                    +     +     +     +                 +     +  +      |             
      Foreign Body                         |                                        2                 4               |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +                    +     +           +                 +        +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | A                    A     +           A                 A        A      |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +                    +     +           +                 A        A      |             
      Inflammation, Necrotizing            |                                                                          |             
      Parasite Metazoan                    |                      X                                                   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +                    +     +           +                 A        +      |             
      Parasite Metazoan                    |                      X                                                   |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +                    +     +           +                 +        +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | A                    +     +           +                 A        +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | A                    A     +           A                 A        A      |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | A                    A     +           +                 A        A      |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |       X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X|             
      Hepatodiaphragmatic Nodule           |                      X                                                   |             
      Inflammation, Chronic                | 2           2  2  2  2  3     1     1  2  2     1  1  1        2     2  2|             
      Inflammation, Necrotizing            |             1                                                            |             
      Necrosis, Coagulative                | 2                                                           4            |             
      Bile Duct, Hyperplasia               |                      1                                                   |             
      Portal Vein, Intima, Proliferation   |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               | +                    +     +           +                 +        +      |             
      Inflammation, Chronic                | 1                                                                        |             
                                            __________________________________________________________________________|             
   Pancreas                                | +                 +  +     +           +                 +        +      |             
      Inflammation, Chronic                |                                                                   2      |             
      Acinus, Atrophy                      | 2                    2     2                                             |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +                    +     +     +     +                 +  +     +      |             
                                            __________________________________________________________________________|             
   Stomach                                 | +                    +     +           +                 +        +      |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +                    +     +           +                 +        +      |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +                    +     +           +                 +        +      |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   | +                    +     +           +                 +        +      |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +                    +     +     +     +                 +     +  +      |             
                                            __________________________________________________________________________|             
   Heart                                   | +                    +     +           +                 +        +      |             
      Cardiomyopathy, Chronic              | 2                    2     2                                             |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                                                          |             
      Angiectasis                          |                            2                                             |             
      Degeneration, Fatty                  |                2        2              1     2     2                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  27                                                               
NTP Experiment-Test: 05020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:22:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 5| 7| 7|             
                             DAY ON TEST   | 8| 1| 5| 3| 2| 3| 3| 2| 3| 0| 3| 3| 3| 7| 3| 3| 3| 3| 3| 5| 2| 3| 2| 2| 2|             
                                           | 1| 1| 7| 1| 9| 0| 1| 9| 1| 5| 0| 1| 1| 4| 0| 0| 2| 0| 1| 3| 1| 2| 0| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    6 MG/KG                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Hyperplasia                          |             2     1     3  2        2     2                             2|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                2           2                                   2        2|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +                    +     +           +                 +        A      |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +                    +     +           +                 +        M      |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +     +  +     +     +  +  +  +  +     +  +     +  +  +  +  +     +      |             
      Pars Distalis, Atypia Cellular       |                               X                                          |             
      Pars Distalis, Cyst                  |                               X                    X                     |             
      Pars Distalis, Hyperplasia           |       2                 2                 2                              |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +                    +     +           +                 +        +      |             
      C-Cell, Hyperplasia                  |                            2                                             |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +                    +     +           +                 +        +      |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Duct, Dilatation                     |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +           +        +     +     +     +                 +        +      |             
      Cyst                                 |             X                    X                                       |             
                                            __________________________________________________________________________|             
   Oviduct                                 |             +                    +     +                 +        +      |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +           +     +  +  +           +                 +        +      |             
      Dilatation                           | 4                                                                        |             
      Inflammation, Chronic Active         |                                                                          |             
      Endometrium, Hyperplasia, Cystic,    |                                                                          |             
           Glandular                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |          +  +  +  +     +  I  +  +  +     +  +  +  +  +     +  +     +  +|             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femoral, Hyperplasia                 | 3     2     2     4     2  4           3                    3  3         |             
      Femoral, Hyperplasia, Reticulum Cell |             2  3                 4     3  2                              |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +     +           +  +     +     +     +                 +  +  +  +      |             
      Mediastinal, Inflammation,           |                                                                          |             
          Suppurative                      | 2                                                                        |             
      Renal, Cyst                          |                            X                                             |             
      Renal, Inflammation, Chronic Active  |                            3                                             |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +     +              +     +     +     +                 +  +     +      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                                                                          |             
      Cyst                                 |                                                                          |             
      Edema                                |                                                                          |             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  28                                                               
NTP Experiment-Test: 05020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:22:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 5| 7| 7|             
                             DAY ON TEST   | 8| 1| 5| 3| 2| 3| 3| 2| 3| 0| 3| 3| 3| 7| 3| 3| 3| 3| 3| 5| 2| 3| 2| 2| 2|             
                                           | 1| 1| 7| 1| 9| 0| 1| 9| 1| 5| 0| 1| 1| 4| 0| 0| 2| 0| 1| 3| 1| 2| 0| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    6 MG/KG                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                       1                  |             
      Hematopoietic Cell Proliferation     | 4     2  2  3  3  2  3  2  4  3  4  2  4  2  3  2  2  3  3  4  2  2  2  2|             
      Pigmentation, Hemosiderin            | 3  1  3  3  3  3  2  3  3     3  3  3  2  2  3  3  3  3  3  2  2  3  2  2|             
                                            __________________________________________________________________________|             
   Thymus                                  | +                    +     +           +                 +     +  +      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +        +     +  +  +     +     +     +     +        +  +  +     +     +|             
      Hyperplasia, Cystic                  | 2        3           2     3     3     1              2  3  2     2      |             
                                            __________________________________________________________________________|             
   Skin                                    | +        +     +  +  +     +     +     +     +        +  +  +     +     +|             
      Inflammation, Necrotizing            |                            4                                             |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         | +                    +     +           +                 +        +      |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +                    +     +           +                 +        +      |             
      Compression                          |                                                          X        X      |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +                    +     +           +                 +     +  +      |             
      Mediastinum, Inflammation, Chronic   |                                                                          |             
          Active                           |                                                                4         |             
                                            __________________________________________________________________________|             
   Nose                                    | +                    +     +           +                 +  +     +      |             
                                            __________________________________________________________________________|             
   Trachea                                 | +                    +     +     +     +                 +     +  +      |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |          +  +  +  +     +        +  +           +  +  +        +     +   |             
      Inflammation, Chronic                |                                                                          |             
      Lens, Cataract                       |          3  3  3  3     3        3  3           3  3  3        3     3   |             
      Retina, Atrophy                      |          3  3  3  3     3        3  3           3  3  3        3     3   |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +                    +     +           +                 +        +      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy, Chronic                 | 1        2  1  1  2  2  1  2  2  2  1  1  1  1  2  2  2     4  2     2  1|             
      Renal Tubule, Pigmentation,          |                                                                          |             
          Hemosiderin                      | 2  2  2  2  2  2  2  1  2  2  2  2  2  2  2  2  2  2  2  2  3  2  1  2  2|             
                                            __________________________________________________________________________|             
   Ureter                                  |                            +  +                          +           +   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +                    +     +           +                 +        M      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  29                                                               
NTP Experiment-Test: 05020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:22:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 0| 2| 3| 3| 3| 2| 2| 2| 3| 3| 2| 2| 3| 9| 3| 2| 3| 3| 2| 3| 2| 3| 2| 3|            |
                                           | 1| 1| 9| 2| 0| 9| 9| 9| 6| 1| 1| 9| 9| 2| 4| 0| 9| 0| 1| 9| 2| 9| 1| 9| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|      A     |
    6 MG/KG                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |                +        +                 +                 +            |  12        |
      Foreign Body                         |                                           2                              |      3  2.7|
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +              +        +        +        +                 +            |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                A        +        +        A                 A            |   3        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +              A        +                 +                 +            |   8        |
      Inflammation, Necrotizing            | 4                                                                        |      1  4.0|
      Parasite Metazoan                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                A        M                 +                 M            |   6        |
      Parasite Metazoan                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                +        +                 +                 +            |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                +        +                 +                 +            |   8        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                M        +                 A                 A            |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                A        M                 A                 A            |   2        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     | X  X  X  X  X  X  X  X  X  X  X     X  X  X  X  X  X  X  X     X  X  X  X|     46     |
      Hepatodiaphragmatic Nodule           |                            X                                             |      2     |
      Inflammation, Chronic                |          2  2  2     3     3  1  2  1        1  1        2  2  2  2  2  1|     32  1.8|
      Inflammation, Necrotizing            | 2                       3                                                |      3  2.0|
      Necrosis, Coagulative                |                                                                          |      2  3.0|
      Bile Duct, Hyperplasia               |                                                                          |      1  1.0|
      Portal Vein, Intima, Proliferation   |                            2                                             |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |          +     +        +        +                          +            |  11        |
      Inflammation, Chronic                |          2                                                               |      2  1.5|
                                            __________________________________________________________________________|____________|
   Pancreas                                |                +        +                 +     +           +            |  12        |
      Inflammation, Chronic                |                2                                                         |      2  2.0|
      Acinus, Atrophy                      |                                                                          |      3  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                +        +                 +                 +            |  12        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |                +        +                 +                 +            |  10        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                A        +                 +                 +            |   9        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                A        +                 +                 +            |   9        |
                                            __________________________________________________________________________|____________|
   Tongue                                  |                            +                                             |   1        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                +        +                 +                 +            |  10        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                +        +                 +                 +            |  12        |
                                            __________________________________________________________________________|____________|
   Heart                                   |                +        +                 +                 +            |  10        |
      Cardiomyopathy, Chronic              |                2        2                 2                 1            |      7  1.9|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  30                                                               
NTP Experiment-Test: 05020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:22:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 0| 2| 3| 3| 3| 2| 2| 2| 3| 3| 2| 2| 3| 9| 3| 2| 3| 3| 2| 3| 2| 3| 2| 3|            |
                                           | 1| 1| 9| 2| 0| 9| 9| 9| 6| 1| 1| 9| 9| 2| 4| 0| 9| 0| 1| 9| 2| 9| 1| 9| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|      A     |
    6 MG/KG                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Adrenal Cortical Nodule    |                X                                                         |      1     |
      Angiectasis                          |                                                                          |      1  2.0|
      Degeneration, Fatty                  |                                        1     1  1                    2   |      9  1.6|
      Hyperplasia                          | 2              2  3     2           1  2     2  2     1  2           2   |     18  1.9|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |       3  2                       1                                       |      7  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                +        +                 +                 +            |   9        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                +        +                 +                 +            |   9        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |    +  +     +  +  +     +     +     +  +  +     +  +     +  +  +  +  +  +|  35        |
      Pars Distalis, Atypia Cellular       |                                                                          |      1     |
      Pars Distalis, Cyst                  |                   X     X           X  X                       X         |      7     |
      Pars Distalis, Hyperplasia           |       3     2                                   3        2     2  2      |      9  2.2|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                +     +  +                 +                 +            |  11        |
      C-Cell, Hyperplasia                  |                         1                                                |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |                +        +                 +                 +     +      |  11        |
      Hyperplasia                          |                                                                   3      |      1  3.0|
      Inflammation, Chronic Active         |                         2                                                |      1  2.0|
      Duct, Dilatation                     |                                                                   3      |      1  3.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   |          +     +        +              +  +           +     +            |  15        |
      Cyst                                 |          X                                            X                  |      4     |
                                            __________________________________________________________________________|____________|
   Oviduct                                 |          +                             +  +                              |   8        |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +        +  +  +  +     +        +  +     +              +  +            |  20        |
      Dilatation                           | 4        4                          4                    2               |      5  3.6|
      Inflammation, Chronic Active         |                                                          4               |      1  4.0|
      Endometrium, Hyperplasia, Cystic,    |                                                                          |            |
           Glandular                       |             2     4                 2                                    |      3  2.7|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   | +     +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +     +  +     +|  37        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Femoral, Hyperplasia                 | 3        2  2     2  2  3                    2     2  2  3  4     2      |     21  2.6|
      Femoral, Hyperplasia, Reticulum Cell |                                                    2        2            |      7  2.6|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  31                                                               
NTP Experiment-Test: 05020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:22:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 0| 2| 3| 3| 3| 2| 2| 2| 3| 3| 2| 2| 3| 9| 3| 2| 3| 3| 2| 3| 2| 3| 2| 3|            |
                                           | 1| 1| 9| 2| 0| 9| 9| 9| 6| 1| 1| 9| 9| 2| 4| 0| 9| 0| 1| 9| 2| 9| 1| 9| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|      A     |
    6 MG/KG                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +              +  +     +                 +                 +            |  17        |
      Mediastinal, Inflammation,           |                                                                          |            |
          Suppurative                      |                                                                          |      1  2.0|
      Renal, Cyst                          |                                                                          |      1     |
      Renal, Inflammation, Chronic Active  |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                +  +     +                 +                 +            |  14        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +                                                                        |   1        |
      Cyst                                 | X                                                                        |      1     |
      Edema                                | 4                                                                        |      1  4.0|
      Hemorrhage                           | 3                                                                        |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             |          1  1                                                            |      3  1.0|
      Hematopoietic Cell Proliferation     | 1  2  2  2  2     2  2  3  2  1  2  2  2  3  2  2  2  2  2  2  2  2  2  2|     48  2.4|
      Pigmentation, Hemosiderin            | 2  3  3  2  3  3  2  2  2  2  3  3  2  2  3  2  2  2  1  3  2  2  2  2  2|     49  2.4|
                                            __________________________________________________________________________|____________|
   Thymus                                  |                +        +                 +                 +            |  11        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |       +        +        +                 +           +     +     +     +|  22        |
      Hyperplasia, Cystic                  |                2        2                 2           2     2     2     2|     17  2.2|
                                            __________________________________________________________________________|____________|
   Skin                                    |       +        +        +                 +           +     +           +|  21        |
      Inflammation, Necrotizing            |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                +        +                 +                 +            |  10        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                +        +                 +                 +            |  10        |
      Compression                          |                X                          X                              |      4     |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                             +            |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |                +        +                 +                 +            |  11        |
      Mediastinum, Inflammation, Chronic   |                                                                          |            |
          Active                           |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Nose                                    |                +        +                 +                 +            |  11        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |                +        +                 +                 +     +      |  13        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  32                                                               
NTP Experiment-Test: 05020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:22:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 0| 2| 3| 3| 3| 2| 2| 2| 3| 3| 2| 2| 3| 9| 3| 2| 3| 3| 2| 3| 2| 3| 2| 3|            |
                                           | 1| 1| 9| 2| 0| 9| 9| 9| 6| 1| 1| 9| 9| 2| 4| 0| 9| 0| 1| 9| 2| 9| 1| 9| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|      A     |
    6 MG/KG                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |       +  +  +     +  +     +  +  +  +  +     +  +  +  +  +     +  +  +  +|  31        |
      Inflammation, Chronic                |                                                                   3      |      1  3.0|
      Lens, Cataract                       |       3  3  3     3  3     3  3  3  3  3     3  3  3     3     3  3  3  3|     30  3.0|
      Retina, Atrophy                      |       3  3  3     3  3     3  3  3  3  3     3  3  3  3  3     3  3  3  3|     31  3.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                         +     +           +                 +     +      |  11        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Nephropathy, Chronic                 | 1  2  2  1  2  2  1  1  1  2  1  2  2  2  2  1  1  2  2  2     1  1  1  2|     45  1.6|
      Renal Tubule, Pigmentation,          |                                                                          |            |
          Hemosiderin                      | 2  2  2  2  2  1  2  2  2  2  2  2  2  2  2  2  2  2  2  2  1  2  2  2  2|     50  1.9|
                                            __________________________________________________________________________|____________|
   Ureter                                  | +              +        +              +                 +  +           +|  11        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                A        +                 +                 +            |   8        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  33                                                               
NTP Experiment-Test: 05020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:22:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 5| 7| 7| 6| 6| 6| 7| 6| 4| 7| 5| 4| 7| 6| 7| 6| 2| 7| 6| 7|             
                             DAY ON TEST   | 2| 1| 3| 3| 3| 2| 3| 2| 2| 3| 3| 2| 5| 5| 3| 6| 6| 3| 3| 3| 5| 6| 3| 6| 3|             
                                           | 9| 0| 1| 1| 0| 1| 1| 9| 6| 3| 3| 1| 5| 5| 2| 8| 6| 0| 9| 2| 5| 3| 0| 2| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                              4                           |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Parasite Metazoan                    |                                                                         X|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |    X  X     X     X  X  X        X        X              X              X|             
      Degeneration, Cystic                 |          2        2              2  2                    2           1   |             
      Eosinophilic Focus                   |                X     X                    X                              |             
      Hepatodiaphragmatic Nodule           |                                              X                          X|             
      Inflammation, Chronic                | 2                 2     2                                         2      |             
      Inflammation, Necrotizing            |                                        1     2                          2|             
      Necrosis, Coagulative                |                                  2              2                        |             
      Pigmentation, Hemosiderin            |                                                                          |             
      Vacuolization Cytoplasmic            |    2     2                          3                             2      |             
      Bile Duct, Hyperplasia               | 2     1     1  2           2  4  2  2     3  2  1  2  1  1  2     1  2  1|             
                                            __________________________________________________________________________|             
   Mesentery                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |       2                    1     1                                       |             
      Necrosis                             |       4                                                                  |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |       2        2     1  2     4        2  2        2  1                 2|             
      Duct, Ectasia                        |       2                                                                  |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granuloma                            |                                  3                                       |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                  2                                       |             
      Hyperkeratosis                       |                                  2                                       |             
      Inflammation, Chronic Active         |                                  2     4                                 |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Mineralization                       |                                  2                                       |             
      Necrosis, Coagulative                |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                  +                    +                  |             
      Foreign Body                         |                                  2                    2                  |             
      Inflammation, Chronic Active         |                                  3                    3                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  34                                                               
NTP Experiment-Test: 05020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:22:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 5| 7| 7| 6| 6| 6| 7| 6| 4| 7| 5| 4| 7| 6| 7| 6| 2| 7| 6| 7|             
                             DAY ON TEST   | 2| 1| 3| 3| 3| 2| 3| 2| 2| 3| 3| 2| 5| 5| 3| 6| 6| 3| 3| 3| 5| 6| 3| 6| 3|             
                                           | 9| 0| 1| 1| 0| 1| 1| 9| 6| 3| 3| 1| 5| 5| 2| 8| 6| 0| 9| 2| 5| 3| 0| 2| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Peridontal Tissue, Inflammation,     |                                                                          |             
           Chronic Active                  |                         2                 2                              |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesenteric Artery, Intima,           |                                                                          |             
          Proliferation                    |                   3                                                      |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy, Chronic              | 2  2  2     2  2  3  2  3  3  2  2  2  1  3  2  2  2  3  2        3  3  2|             
      Atrium, Thrombosis                   |                                                                          |             
      Endocardium, Proliferation           |                                                                   2      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Fatty                  |                                  2                          2     2      |             
      Hyperplasia                          |    2        2     2                 2              2     3        2     2|             
      Hypertrophy                          |                                                                          |             
      Necrosis, Coagulative                |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2              2                 2  2                       2        2   |             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration                         |                                     2                                    |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                               X                                          |             
      Pars Distalis, Hyperplasia           | 2                                            3     2                     |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 |                            X                                             |             
      C-Cell, Hyperplasia                  |    2  2  2  2  2  2  2     2  2                       2     2     2      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy, Diffuse                     |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic Active         |    2  2     2  2  3  2  2  2  3  2  2  3  2  2  2  2  2  2  2  3  1  2  2|             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |    2        3  3     3  1  2     2  2  2  2  2        2        1  2  2   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  35                                                               
NTP Experiment-Test: 05020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:22:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 5| 7| 7| 6| 6| 6| 7| 6| 4| 7| 5| 4| 7| 6| 7| 6| 2| 7| 6| 7|             
                             DAY ON TEST   | 2| 1| 3| 3| 3| 2| 3| 2| 2| 3| 3| 2| 5| 5| 3| 6| 6| 3| 3| 3| 5| 6| 3| 6| 3|             
                                           | 9| 0| 1| 1| 0| 1| 1| 9| 6| 3| 3| 1| 5| 5| 2| 8| 6| 0| 9| 2| 5| 3| 0| 2| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  M     +  +  +  M  +  +  +  +  +  +  +  +  +  +     +|             
      Inflammation, Chronic Active         |          2     2           2                                             |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Interstitial Cell, Hyperplasia       |          1  1              2  2  2  2     2  2  2     1           2      |             
      Seminiferous Tubule, Atrophy         | 4     4  4  4     4  4  4     4  4           2     4  4  4  4        2  4|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   | +  +  +  +  +  +  +  +  +  +  +  +  +     +        +  +  +  +  +  +  +  +|             
      Leukocytosis                         |                                                       X                  |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femoral, Hyperplasia                 | 3        2        3                       3        3  4  3  4  3     4  3|             
      Femoral, Myelofibrosis               |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +                    +              +           +                        |             
      Cyst                                 | X                                                                        |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                   2                       2                              |             
      Hematopoietic Cell Proliferation     | 1  1  1     2  1  1  1  2  1        1     2  2     1  4  1  2  2  1     1|             
      Infarct, Acute                       |                                                                          |             
      Pigmentation, Hemosiderin            | 1  2  1  1  1  2  1  1     1  1  1     2  1  1     1  1  2  1     1  1  1|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +|             
      Cyst                                 |                                  X                                       |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  +  +  M  M  +  +  +  +  +  +  +  +  M  +  +  +  M  M  M  +  M  M  M  M|             
      Hyperplasia, Cystic                  |    4           2  1  3  1     1  4  2     3  2              3            |             
                                            __________________________________________________________________________|             
   Skin                                    | M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                        2                                 |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         | M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |    X           X                       X                                 |             
      Hemorrhage, Acute                    |                                                 3                        |             
      Hydrocephalus                        |    2           2                       2                          4      |             
      Infarct, Chronic                     |       2                                                                  |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                        +                                 |             
      Degeneration                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  36                                                               
NTP Experiment-Test: 05020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:22:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 5| 7| 7| 6| 6| 6| 7| 6| 4| 7| 5| 4| 7| 6| 7| 6| 2| 7| 6| 7|             
                             DAY ON TEST   | 2| 1| 3| 3| 3| 2| 3| 2| 2| 3| 3| 2| 5| 5| 3| 6| 6| 3| 3| 3| 5| 6| 3| 6| 3|             
                                           | 9| 0| 1| 1| 0| 1| 1| 9| 6| 3| 3| 1| 5| 5| 2| 8| 6| 0| 9| 2| 5| 3| 0| 2| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 1|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage, Acute                    |                                                 3                        |             
      Inflammation, Chronic                |    2        2                                                            |             
      Pigmentation, Hemosiderin            |          2                                                               |             
      Alveolar Epithelium, Hyperplasia     |       2                                                           2      |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                             3            |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     | 2                                         2                       1      |             
      Septum, Thrombosis, Multiple         |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |       +                             +                                    |             
      Lens, Cataract                       |       3                             4                                    |             
      Retina, Atrophy                      |       4                             4                                    |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy, Chronic                 | 3  3  3  3  2  3  4  4  2  2  3  4  4     3  2  2  3  3  3  3     4  3  3|             
      Renal Tubule, Pigmentation,          |                                                                          |             
          Hemosiderin                      | 1  1  1  2  1  1  1  1  1  1  1  1     2  2  1  1  1  1  1  1  1  1  1  1|             
                                            __________________________________________________________________________|             
   Ureter                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Urethra                                 | +  +  +  +  +  +  +  +     +        +     +           +  +  +  +         |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage, Acute                    |                                                 2                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  37                                                               
NTP Experiment-Test: 05020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:22:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 5| 7| 6| 6| 3| 0| 7| 5| 7| 6| 7| 6| 7| 6| 5| 7| 6| 5| 7|  |            |
                             DAY ON TEST   | 3| 2| 3| 2| 3| 7| 3| 8| 2| 3| 7| 0| 5| 3| 7| 0| 8| 3| 4| 1| 0| 8| 8| 2|  |            |
                                           | 2| 9| 0| 8| 1| 8| 2| 8| 7| 0| 2| 9| 4| 1| 4| 1| 8| 0| 7| 2| 4| 0| 4| 3|  |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|  |      A     |
    VEHICLE                                | 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|  |      L     |
                                           | 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|  |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Foreign Body                         |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +   |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  A  +  M  +  +  +  +  +  +  +  +  +  +  +   |  46        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  M  +  +  +  +   |  46        |
      Parasite Metazoan                    |                   X                                                      |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +   |  47        |
      Inflammation, Chronic Active         |                                     2                       1            |      2  1.5|
      Parasite Metazoan                    |                                  X                                       |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +   |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +   |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  M  +  +  +   |  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +   |  46        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Basophilic Focus                     |             X                    X        X        X                     |     14     |
      Degeneration, Cystic                 |                                  2  2        2  2                        |     10  1.9|
      Eosinophilic Focus                   |                                                                          |      3     |
      Hepatodiaphragmatic Nodule           |                                                             X            |      3     |
      Inflammation, Chronic                |          2     2                                         1  1            |      8  1.8|
      Inflammation, Necrotizing            |                                                             2            |      4  1.8|
      Necrosis, Coagulative                |                      2                                2        2     1   |      6  1.8|
      Pigmentation, Hemosiderin            |                                     2                                    |      1  2.0|
      Vacuolization Cytoplasmic            |                                     4  2                                 |      6  2.5|
      Bile Duct, Hyperplasia               | 1  2  2  2  2  2  1  3  2  1     3  2  1  2  3  2  1  3  2  2  3  2  3   |     41  1.9|
                                            __________________________________________________________________________|____________|
   Mesentery                               | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +   |  47        |
      Inflammation, Chronic                |                         3                             4     2            |      6  2.2|
      Necrosis                             |                         4                             4                  |      3  4.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +   |  48        |
      Acinus, Atrophy                      |                      1  2        1        3     3  1  1           1      |     18  1.8|
      Duct, Ectasia                        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Granuloma                            |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +   |  48        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  M  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +   |  47        |
      Acanthosis                           |                                                                          |      1  2.0|
      Hyperkeratosis                       |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +   |  48        |
      Inflammation, Chronic Active         |       2                                                                  |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  38                                                               
NTP Experiment-Test: 05020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:22:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 5| 7| 6| 6| 3| 0| 7| 5| 7| 6| 7| 6| 7| 6| 5| 7| 6| 5| 7|  |            |
                             DAY ON TEST   | 3| 2| 3| 2| 3| 7| 3| 8| 2| 3| 7| 0| 5| 3| 7| 0| 8| 3| 4| 1| 0| 8| 8| 2|  |            |
                                           | 2| 9| 0| 8| 1| 8| 2| 8| 7| 0| 2| 9| 4| 1| 4| 1| 8| 0| 7| 2| 4| 0| 4| 3|  |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|  |      A     |
    VEHICLE                                | 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|  |      L     |
                                           | 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|  |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Mineralization                       |                                                                          |      1  2.0|
      Necrosis, Coagulative                |                                     2                                    |      1  2.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   2        |
      Foreign Body                         |                                                                          |      2  2.0|
      Inflammation, Chronic Active         |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Peridontal Tissue, Inflammation,     |                                                                          |            |
           Chronic Active                  |                                                                          |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Mesenteric Artery, Intima,           |                                                                          |            |
          Proliferation                    |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Cardiomyopathy, Chronic              | 3  3  2  2  3  3  3  2  2  2  2  2  2  2  2  2  2  3     2  2  2  2      |     44  2.3|
      Atrium, Thrombosis                   |             X                       X  X        X              X         |      5     |
      Endocardium, Proliferation           |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Degeneration, Fatty                  |                      2     2           2     2        2        2     2   |     10  2.0|
      Hyperplasia                          | 2     2           2  2  2                    3                 2  2  3   |     17  2.2|
      Hypertrophy                          |             2                                                            |      1  2.0|
      Necrosis, Coagulative                |                      2                                         1         |      2  1.5|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Hyperplasia                          |    2  2     2                    2     3        2  2  2              2   |     15  2.1|
      Mineralization                       |                                                             3            |      1  3.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +   |  48        |
      Degeneration                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  48        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  47        |
      Pars Distalis, Cyst                  |                      X                             X                     |      3     |
      Pars Distalis, Hyperplasia           |    2                 2     2                 2     3        2  3  2      |     11  2.3|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +   |  48        |
      Ultimobranchial Cyst                 |                                                                          |      1     |
      C-Cell, Hyperplasia                  |    2                 2  1           2  2     2                       2   |     19  1.9|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  39                                                               
NTP Experiment-Test: 05020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:22:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 5| 7| 6| 6| 3| 0| 7| 5| 7| 6| 7| 6| 7| 6| 5| 7| 6| 5| 7|  |            |
                             DAY ON TEST   | 3| 2| 3| 2| 3| 7| 3| 8| 2| 3| 7| 0| 5| 3| 7| 0| 8| 3| 4| 1| 0| 8| 8| 2|  |            |
                                           | 2| 9| 0| 8| 1| 8| 2| 8| 7| 0| 2| 9| 4| 1| 4| 1| 8| 0| 7| 2| 4| 0| 4| 3|  |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|  |      A     |
    VEHICLE                                | 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|  |      L     |
                                           | 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|  |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Atrophy, Diffuse                     |                                                                   2      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  46        |
      Hyperplasia                          |                                                 3           3            |      2  3.0|
      Inflammation, Chronic Active         | 2  2  2  3     2  2  2  2  2     2  3  2  2  3  2  2  2  1  2  2  2  2   |     45  2.1|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Inflammation, Chronic Active         | 2  1  2  2  1        2  2        2  2  2  2  2  3  2     2     2     3   |     32  2.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +     +  +  +  +  +  +              +  +     +     +        +  +   |  36        |
      Inflammation, Chronic Active         |                                                                          |      3  2.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Interstitial Cell, Hyperplasia       |    1     2     2     2  2  2        2  2     2  2  2  2     2     2  2   |     26  1.8|
      Seminiferous Tubule, Atrophy         | 4  4  4  3  4  4  4              4  3  4  4  3     3  3     3  3  4      |     33  3.7|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   | +  +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +   |  44        |
      Leukocytosis                         |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Femoral, Hyperplasia                 | 3  3  3  3        2  4  3        4        4     4  3  3        4  3  3   |     26  3.2|
      Femoral, Myelofibrosis               |                                     2                                    |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  48        |
      Cyst                                 |                                           X     X  X              X      |      4     |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |             +        +           +           +     +                 +   |  10        |
      Cyst                                 |                      X                                                   |      2     |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Fibrosis                             |                                                 2                        |      3  2.0|
      Hematopoietic Cell Proliferation     | 1  1     2  1  2  1     1  1           1        2  1     1               |     31  1.4|
      Infarct, Acute                       |                      4                                                   |      1  4.0|
      Pigmentation, Hemosiderin            | 1  1     1  1  2  1     1  1        1  1  1     1  1  1  1     1         |     37  1.1|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +   |  43        |
      Cyst                                 |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  M  +  +  +  +  +  +  M  M  M  +  +  +  +  M  +  +  +  +  +  +  +  M   |  32        |
      Hyperplasia, Cystic                  | 1     1     2     2  2           2  2  2  3     2  2     3  2  3         |     25  2.2|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  47        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  40                                                               
NTP Experiment-Test: 05020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:22:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 5| 7| 6| 6| 3| 0| 7| 5| 7| 6| 7| 6| 7| 6| 5| 7| 6| 5| 7|  |            |
                             DAY ON TEST   | 3| 2| 3| 2| 3| 7| 3| 8| 2| 3| 7| 0| 5| 3| 7| 0| 8| 3| 4| 1| 0| 8| 8| 2|  |            |
                                           | 2| 9| 0| 8| 1| 8| 2| 8| 7| 0| 2| 9| 4| 1| 4| 1| 8| 0| 7| 2| 4| 0| 4| 3|  |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|  |      A     |
    VEHICLE                                | 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|  |      L     |
                                           | 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|  |            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  48        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  47        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Compression                          |                                                          X               |      4     |
      Hemorrhage, Acute                    |                                                                          |      1  3.0|
      Hydrocephalus                        |                                                          3               |      5  2.6|
      Infarct, Chronic                     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                +                                                         |   1        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                +           +                                   +         |   4        |
      Degeneration                         |                            4                                             |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Hemorrhage, Acute                    |                                  3              2                        |      3  2.7|
      Inflammation, Chronic                |                                                                          |      2  2.0|
      Pigmentation, Hemosiderin            |                                                                          |      1  2.0|
      Alveolar Epithelium, Hyperplasia     | 2                                                                        |      3  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +   |  48        |
      Inflammation, Chronic Active         | 2                             3           4     2     2                  |      6  2.7|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |                   1                                                      |      4  1.5|
      Septum, Thrombosis, Multiple         |                                     X                                    |      1     |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |       +           +  +                                            +  +   |   7        |
      Lens, Cataract                       |       3              3                                                   |      4  3.3|
      Retina, Atrophy                      |       3              4                                               3   |      5  3.6|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M   |  46        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +   |  48        |
      Nephropathy, Chronic                 | 4  3  3  2  4  2  3  2  2  2     2  2  4  2  2  2  3  2  2  3  2  2  3   |     46  2.8|
      Renal Tubule, Pigmentation,          |                                                                          |            |
          Hemosiderin                      | 1  1  1  1  1  1  1  2  1  1     1  2  1  2  2  3  2  1  1  1  1  2  1   |     47  1.2|
                                            __________________________________________________________________________|____________|
   Ureter                                  | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  47        |
                                            __________________________________________________________________________|____________|
   Urethra                                 |                                  +     +  +  +        +     +            |  21        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  41                                                               
NTP Experiment-Test: 05020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:22:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 5| 7| 6| 6| 3| 0| 7| 5| 7| 6| 7| 6| 7| 6| 5| 7| 6| 5| 7|  |            |
                             DAY ON TEST   | 3| 2| 3| 2| 3| 7| 3| 8| 2| 3| 7| 0| 5| 3| 7| 0| 8| 3| 4| 1| 0| 8| 8| 2|  |            |
                                           | 2| 9| 0| 8| 1| 8| 2| 8| 7| 0| 2| 9| 4| 1| 4| 1| 8| 0| 7| 2| 4| 0| 4| 3|  |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|  |      A     |
    VEHICLE                                | 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|  |      L     |
                                           | 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|  |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  M  +  +  +  +   |  47        |
      Hemorrhage, Acute                    |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  42                                                               
NTP Experiment-Test: 05020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:22:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 6| 6| 4| 7| 7| 6| 5| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 1| 3| 1| 2| 3| 5| 9| 8| 3| 3| 8| 5| 3| 3| 2| 3| 7| 3| 5| 3| 3| 3| 3|             
                                           | 2| 0| 6| 2| 5| 9| 2| 1| 3| 6| 0| 1| 7| 6| 2| 1| 9| 1| 3| 2| 1| 0| 2| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    2 MG/KG                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |                            +           +                                 |             
      Inflammation, Necrotizing            |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         |                +           +           +                                 |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |                            +           +                                 |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                            +           +                                 |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |                            +           +                                 |             
                                            __________________________________________________________________________|             
   Intestine Small                         |                            +           +                    +            |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |                            +           +                                 |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |                            +           +                                 |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                            +           +                    +            |             
      Metaplasia, Osseous                  |                                        3                                 |             
      Necrosis                             |                                        3                                 |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                   2      |             
      Basophilic Focus                     | X  X     X        X           X  X  X        X     X     X        X      |             
      Degeneration, Cystic                 |    3           2        2        2  2                    1        2  2  1|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hepatodiaphragmatic Nodule           | X  X                 X     X           X           X  X           X      |             
      Inflammation, Chronic                | 1  1                       1     2                 1     1               |             
      Inflammation, Necrotizing            |             3              2                                             |             
      Necrosis, Coagulative                |                                                             3            |             
      Vacuolization Cytoplasmic            |                                        2                                 |             
      Bile Duct, Hyperplasia               | 2  2     1  2  2  2  2  2  2  2  2  2  2  2  2  2  2     1  3  2  2  2  2|             
                                            __________________________________________________________________________|             
   Mesentery                               |                            +           +                 +  +  +         |             
      Inflammation, Chronic                |                            3           3                 3  3  3         |             
      Necrosis                             |                            4                             4     4         |             
                                            __________________________________________________________________________|             
   Pancreas                                |                            M           +                                 |             
      Pigmentation, Hemosiderin            |                                                                          |             
      Acinus, Atrophy                      |                                                                          |             
      Duct, Ectasia                        |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |                            +           +                                 |             
                                            __________________________________________________________________________|             
   Stomach                                 |                            +           +                                 |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |                            +           +                                 |             
      Inflammation, Necrotizing            |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |                            +           +                                 |             
      Necrosis, Coagulative                |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                   +      |             
      Inflammation, Chronic Active         |                                                                   2      |             
                                            __________________________________________________________________________|             
   Tooth                                   |                            +           +                                 |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +     +                    +           +     +                           |             
      Pulmonary Artery, Thrombosis         |       X                                                                  |             
                                            __________________________________________________________________________|             
   Heart                                   |    +  +     +           +  +  +        +                             +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  43                                                               
NTP Experiment-Test: 05020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:22:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 6| 6| 4| 7| 7| 6| 5| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 1| 3| 1| 2| 3| 5| 9| 8| 3| 3| 8| 5| 3| 3| 2| 3| 7| 3| 5| 3| 3| 3| 3|             
                                           | 2| 0| 6| 2| 5| 9| 2| 1| 3| 6| 0| 1| 7| 6| 2| 1| 9| 1| 3| 2| 1| 0| 2| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    2 MG/KG                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Cardiomyopathy, Chronic              |    2        2           2  4  2        2                             2   |             
      Atrium, Thrombosis                   |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Fatty                  |                         2                                            2   |             
      Hyperplasia                          | 2  2     2  1           2              2                    2            |             
      Hypertrophy                          |                                                                          |             
      Necrosis, Coagulative                |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 1     2        1                    3  2     2  2     1        2     2   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |                            M           +                                 |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |       +        +           +           +                                 |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +        +              +           +                 +     +        +|             
      Pars Distalis, Angiectasis           |                                                                          |             
      Pars Distalis, Hyperplasia           |                                        2                                 |             
      Pars Distalis, Pigmentation,         |                                                                          |             
          Hemosiderin                      |                                                                          |             
      Pars Intermedia, Angiectasis         |                                                                         3|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |       A        +           +           +  +                              |             
      C-Cell, Hyperplasia                  |                2           2           2                                 |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +           +  +     +  +           +           +        +  +  +      |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |             +        +     +     +  +  +              +                  |             
      Inflammation, Chronic Active         |             3        3     2           2                                 |             
                                            __________________________________________________________________________|             
   Prostate                                |                            +           +                                 |             
      Inflammation, Chronic Active         |                            3           1                                 |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                                        +                                 |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Interstitial Cell, Hyperplasia       |    2     2     2  1  1        2  2  1  2           2  2  1  1  1        1|             
      Seminiferous Tubule, Atrophy         | 4  2  3  4     4  4  4  4     4  4  4  2  4  4  4  4  4  4  4  4  4     4|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   | +  +     +     +  +     +  +  +  +     +  +  +  +  +  +  +     +  +  +  +|             
      Neutrophilia                         |                         X                             X                  |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femoral, Hyperplasia                 |          2  2  4  3  4  4     3  4  4  4  4  4  3  3  4  2  4  2  2     3|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +              +        +  +        +  +     +           +  +            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  44                                                               
NTP Experiment-Test: 05020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:22:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 6| 6| 4| 7| 7| 6| 5| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 1| 3| 1| 2| 3| 5| 9| 8| 3| 3| 8| 5| 3| 3| 2| 3| 7| 3| 5| 3| 3| 3| 3|             
                                           | 2| 0| 6| 2| 5| 9| 2| 1| 3| 6| 0| 1| 7| 6| 2| 1| 9| 1| 3| 2| 1| 0| 2| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    2 MG/KG                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Mediastinal, Hyperplasia, Plasma Cell|                            3                                             |             
      Renal, Cyst                          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |                +        +              +                                 |             
      Ectasia                              |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                            +           +                 +  +            |             
      Cyst                                 |                                        X                    X            |             
      Fibrosis                             |                                                             2            |             
      Infiltration Cellular, Histiocyte    |                            2                                             |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |       2           4                 3     3        1     1              3|             
      Hematopoietic Cell Proliferation     | 2  2  2  2  1  2  1  3  4  2  2  2  2  3  2  1  2  1  4  1  3  1  1  1  1|             
      Pigmentation, Hemosiderin            | 2  1     2  1     2     1  2  2        1  1  2  2  2     2  1  2  2  1  2|             
                                            __________________________________________________________________________|             
   Thymus                                  | +                          +           +     +                           |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +           +              +     +     +                                 |             
      Hyperplasia, Cystic                  | 2           2              3     1     2                                 |             
                                            __________________________________________________________________________|             
   Skin                                    | +           +           +  +     +  +  +        +     +                  |             
      Inflammation, Necrotizing            |                                                                          |             
      Inflammation, Suppurative            |                                  2                                       |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femur, Fibrous Osteodystrophy        |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                            +           +                                 |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |                            +           +                                 |             
      Hydrocephalus                        |                            3                                             |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                            +                                             |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |                            +           +                    +            |             
      Inflammation, Chronic                |                                                                          |             
      Mediastinum, Inflammation, Chronic   |                                                                          |             
          Active                           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |                            +           +                                 |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 |                            +           +                                 |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     | +  +        +                 +                                          |             
      Hemorrhage, Acute                    |                                                                          |             
      Cornea, Inflammation, Chronic Active |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  45                                                               
NTP Experiment-Test: 05020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:22:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 6| 6| 4| 7| 7| 6| 5| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 1| 3| 1| 2| 3| 5| 9| 8| 3| 3| 8| 5| 3| 3| 2| 3| 7| 3| 5| 3| 3| 3| 3|             
                                           | 2| 0| 6| 2| 5| 9| 2| 1| 3| 6| 0| 1| 7| 6| 2| 1| 9| 1| 3| 2| 1| 0| 2| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    2 MG/KG                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Lens, Cataract                       | 3  3        3                 3                                          |             
      Retina, Atrophy                      | 3  3        3                 3                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                            +                                             |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Hemorrhagic            |                                                                          |             
      Nephropathy, Chronic                 | 3  3  3  3  2  4  3  2  3  3  4  3  2  2  4  3  3  3  2  3  2  2  4  2  3|             
      Renal Tubule, Degeneration           |                                                                          |             
      Renal Tubule, Pigmentation,          |                                                                          |             
          Hemosiderin                      | 2  1  1  1  1  1  1     1  2  1  1  1  1  1  2  1  1  1  2  2  2  1  1  2|             
                                            __________________________________________________________________________|             
   Ureter                                  | +  +           +  +        +  +        +  +  +     +     +  +  +         |             
                                            __________________________________________________________________________|             
   Urethra                                 |                            +                                             |             
      Inflammation, Hemorrhagic            |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |                            +           +                 +               |             
      Dilatation                           |                                                          4               |             
      Inflammation, Hemorrhagic            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  46                                                               
NTP Experiment-Test: 05020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:22:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 6| 5| 7| 7| 6| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 2| 2| 2| 5| 2| 3| 3| 5| 2| 3| 5| 2| 3| 3| 3| 5| 2| 3| 3| 3| 7| 3| 1| 3|            |
                                           | 1| 9| 9| 6| 4| 9| 1| 1| 4| 9| 2| 1| 7| 0| 0| 1| 4| 9| 2| 0| 2| 4| 1| 4| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    2 MG/KG                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |          +     +                    +                                    |   5        |
      Inflammation, Necrotizing            |                                     3                                    |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         |          +     +                    +                 +                  |   7        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |          +     +                    +                                    |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |          +     +                    +                                    |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |          +     +                    +                                    |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |          +     +                    +                                    |   6        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |          +     +                    +                                    |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |          +     +                    +                                    |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |          +     +                    +                                    |   6        |
      Metaplasia, Osseous                  |                                                                          |      1  3.0|
      Necrosis                             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                          |      1  2.0|
      Basophilic Focus                     |    X  X  X           X  X  X  X  X     X  X  X                    X      |     23     |
      Degeneration, Cystic                 |    2        2        1     2     2  1  1                                 |     16  1.8|
      Hematopoietic Cell Proliferation     |          1                                                               |      1  1.0|
      Hepatodiaphragmatic Nodule           |                                                                          |      8     |
      Inflammation, Chronic                | 2     1           1           1        3  1           1     1     1      |     15  1.3|
      Inflammation, Necrotizing            |                                                                          |      2  2.5|
      Necrosis, Coagulative                |                                  2                             2     2   |      4  2.3|
      Vacuolization Cytoplasmic            |             2                                   3     1                  |      4  2.0|
      Bile Duct, Hyperplasia               | 2  1  1  1     1  1     1  1  2  2  2  1  2  2     2  1  2  1  2  2  3  2|     45  1.8|
                                            __________________________________________________________________________|____________|
   Mesentery                               |          +     +                 +  +                                +  +|  11        |
      Inflammation, Chronic                |                                                                         3|      6  3.0|
      Necrosis                             |                                                                         4|      4  4.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +        +     +                 +  +                          +     +   |   8        |
      Pigmentation, Hemosiderin            |                                                                      3   |      1  3.0|
      Acinus, Atrophy                      | 3                                   2                                1   |      3  2.0|
      Duct, Ectasia                        |                                     2                                    |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |          +     +                 +  +                                    |   6        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |          +     +                    +           +                        |   6        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |          +     +                    +           +                        |   6        |
      Inflammation, Necrotizing            |                                                 4                        |      1  4.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |          +     +                    +           +                        |   6        |
      Necrosis, Coagulative                |                2                                2                        |      2  2.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |          +     +                    +                                    |   5        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  47                                                               
NTP Experiment-Test: 05020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:22:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 6| 5| 7| 7| 6| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 2| 2| 2| 5| 2| 3| 3| 5| 2| 3| 5| 2| 3| 3| 3| 5| 2| 3| 3| 3| 7| 3| 1| 3|            |
                                           | 1| 9| 9| 6| 4| 9| 1| 1| 4| 9| 2| 1| 7| 0| 0| 1| 4| 9| 2| 0| 2| 4| 1| 4| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    2 MG/KG                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |          +     +                    +                                    |   8        |
      Pulmonary Artery, Thrombosis         |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +     +     +     +           +  +                 +  +           +   |  18        |
      Cardiomyopathy, Chronic              | 2        2     2     2           2  2                    2           2   |     15  2.1|
      Atrium, Thrombosis                   |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Degeneration, Fatty                  | 1        2  1  2                    2           2              2  1     2|     11  1.7|
      Hyperplasia                          | 2           2        2                 2                          1     2|     13  1.8|
      Hypertrophy                          |                                     2                                    |      1  2.0|
      Necrosis, Coagulative                |                                     2                                    |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          | 2  1  1  1     3  2     2  2        2     2              2     3         |     22  1.9|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |          +     +                    +                                    |   4        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |          +     +                    +                                    |   7        |
      Hyperplasia                          |          2                                                               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +     +  +  +  +           +        M     +     +        +        +  +   |  18        |
      Pars Distalis, Angiectasis           |       4                                                                  |      1  4.0|
      Pars Distalis, Hyperplasia           |          2                                                               |      2  2.0|
      Pars Distalis, Pigmentation,         |                                                                          |            |
          Hemosiderin                      |                                           1                              |      1  1.0|
      Pars Intermedia, Angiectasis         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |          +     +                    +                       +            |   8        |
      C-Cell, Hyperplasia                  |          1                                                               |      4  1.8|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |    +     +     +  +                 +     +                       +  +  +|  20        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |          +     +        +           +                 +                  |  12        |
      Inflammation, Chronic Active         |                2                    2                                    |      6  2.3|
                                            __________________________________________________________________________|____________|
   Prostate                                |          +     +                    +                                +   |   6        |
      Inflammation, Chronic Active         |                2                                                     2   |      4  2.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                                     +                                +   |   3        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  48                                                               
NTP Experiment-Test: 05020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:22:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 6| 5| 7| 7| 6| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 2| 2| 2| 5| 2| 3| 3| 5| 2| 3| 5| 2| 3| 3| 3| 5| 2| 3| 3| 3| 7| 3| 1| 3|            |
                                           | 1| 9| 9| 6| 4| 9| 1| 1| 4| 9| 2| 1| 7| 0| 0| 1| 4| 9| 2| 0| 2| 4| 1| 4| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    2 MG/KG                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Testes                                  |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|  46        |
      Interstitial Cell, Hyperplasia       |          2  2  2        2  1  1  2  2     1  1        1  1     1     1   |     29  1.5|
      Seminiferous Tubule, Atrophy         |    4  4  4  4     4  4  4  4  4  4  3  4  4  3     4  4  4  4  4  4  4  4|     44  3.8|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
      Neutrophilia                         |                                                                          |      2     |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Femoral, Hyperplasia                 |    3     3     4     4  4  4  3  4  2  3     3     3  3        3     4  3|     36  3.3|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |          +     +                 +  +  +     +                 +         |  16        |
      Mediastinal, Hyperplasia, Plasma Cell|                                                                          |      1  3.0|
      Renal, Cyst                          |                                        X                                 |      1     |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |          +     +                 +  +                                    |   7        |
      Ectasia                              |                                  2                                       |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                                              +                           |   5        |
      Cyst                                 |                                                                          |      2     |
      Fibrosis                             |                                                                          |      1  2.0|
      Infiltration Cellular, Histiocyte    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             |                                        1        2  1  3                  |     11  2.2|
      Hematopoietic Cell Proliferation     | 1  1  1  2  3  3  3  1  4  1  1  4  1  2  1     1  1  1  1  1     1  4  1|     48  1.8|
      Pigmentation, Hemosiderin            | 2  1  2     3  2  2  2     1  2     2  2  2  2  2  2  1  2  1     2     1|     39  1.7|
                                            __________________________________________________________________________|____________|
   Thymus                                  |          M     M                    +                                    |   5        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |          M     +                    M                                    |   6        |
      Hyperplasia, Cystic                  |                2                                                         |      6  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    |          +     +  +     +  +        +  +              +              +   |  18        |
      Inflammation, Necrotizing            |                                                       3                  |      1  3.0|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Femur, Fibrous Osteodystrophy        |                                        X                                 |      1     |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |          +     +                    +                                +   |   6        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |          +     +                    +                                    |   5        |
      Hydrocephalus                        |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  49                                                               
NTP Experiment-Test: 05020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:22:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 6| 5| 7| 7| 6| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 2| 2| 2| 5| 2| 3| 3| 5| 2| 3| 5| 2| 3| 3| 3| 5| 2| 3| 3| 3| 7| 3| 1| 3|            |
                                           | 1| 9| 9| 6| 4| 9| 1| 1| 4| 9| 2| 1| 7| 0| 0| 1| 4| 9| 2| 0| 2| 4| 1| 4| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    2 MG/KG                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |          +     +                 +  +                                    |   7        |
      Inflammation, Chronic                |                                     2                                    |      1  2.0|
      Mediastinum, Inflammation, Chronic   |                                                                          |            |
          Active                           |                                     3                                    |      1  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    |          +     +                    +                                    |   5        |
      Inflammation, Suppurative            |                                     2                                    |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 |          +     +                    +                                    |   5        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     | +     +              +           +     +  +           +                  |  11        |
      Hemorrhage, Acute                    |                      2                                                   |      1  2.0|
      Cornea, Inflammation, Chronic Active |                                        3                                 |      1  3.0|
      Lens, Cataract                       | 3     3              3           3     3  3           3                  |     11  3.0|
      Retina, Atrophy                      | 3     3              3           3     3  3           3                  |     11  3.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |          +           +                                   +               |   4        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Hemorrhagic            |                4                                                         |      1  4.0|
      Nephropathy, Chronic                 | 3  4  3  2  4  2  3  4  3  3  3  2  3  4  3  3  4  3  3  3  3  3  3  2  2|     50  2.9|
      Renal Tubule, Degeneration           |                3                                                         |      1  3.0|
      Renal Tubule, Pigmentation,          |                                                                          |            |
          Hemosiderin                      | 1  1  2  1  1  2  1  1  1  1  2  4  1  1  1  2  1  2  1  1  1  2  2  3  1|     49  1.4|
                                            __________________________________________________________________________|____________|
   Ureter                                  | +     +  +     +                    +           +  +  +  +  +        +   |  24        |
                                            __________________________________________________________________________|____________|
   Urethra                                 |                +                                                     +   |   3        |
      Inflammation, Hemorrhagic            |                2                                                         |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |          +     +                    +                                +   |   7        |
      Dilatation                           |                                                                          |      1  4.0|
      Inflammation, Hemorrhagic            |                2                                                         |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  50                                                               
NTP Experiment-Test: 05020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:22:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 4| 6| 7| 7| 6| 7| 6| 6| 7| 7| 6| 7| 5| 7| 7| 5| 6| 6| 5| 5| 6|             
                             DAY ON TEST   | 2| 5| 3| 3| 7| 8| 1| 3| 2| 3| 7| 7| 2| 2| 1| 0| 2| 3| 3| 3| 2| 8| 8| 5| 8|             
                                           | 2| 4| 0| 2| 6| 6| 2| 0| 2| 1| 4| 6| 8| 8| 8| 0| 2| 0| 0| 5| 4| 6| 4| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    18 MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |             4                                                            |             
      Inflammation, Necrotizing            |             4                                                            |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  A  +  +  +  A  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  A  +  +  +  A  +  +  +  +  +  A  A  +  +  +  +  A  +  +  +  +|             
      Dilatation                           |                                                                      2   |             
      Inflammation, Chronic Active         |                                                                      2   |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  A  +  +  +  A  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                        X                                 |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  A  +  +  +  A  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  M  +  +  A  +  +  +  A  +  +  A  +  +  A  A  +  +  A  +  A  +  +  +  +|             
      Dilatation                           |                                                                      2   |             
      Inflammation, Chronic Active         |                                                                      2   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  A  +  +  A  +  +  +  A  +  +  A  +  +  A  A  +  +  A  +  +  +  +  +  +|             
      Dilatation                           |                                                                      2   |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | X     X              X     X              X        X           X     X   |             
      Clear Cell Focus                     |                                                                          |             
      Degeneration, Cystic                 | 2              1     2              1                                   2|             
      Eosinophilic Focus                   |                                                                         X|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hepatodiaphragmatic Nodule           |                      X                                                   |             
      Inflammation, Chronic                |          1           2        2                    1                     |             
      Inflammation, Necrotizing            |                                           2                    1        2|             
      Necrosis, Coagulative                |                                                       2  3  3        4   |             
      Pigmentation, Hemosiderin            | 2  2  2  2           2     1  3  2  2  2              1        1         |             
      Vacuolization Cytoplasmic            |                                                                          |             
      Bile Duct, Hyperplasia               | 2  1  2  2  2  1  2  1  2  1  2  1  3  1  2     2  1  2     2  1  2     1|             
                                            __________________________________________________________________________|             
   Mesentery                               | +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectopic Tissue                       |                                                                          |             
      Inflammation, Chronic                |                            2                                         2   |             
      Pigmentation, Hemosiderin            |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Acinus, Atrophy                      |       2              2                 2  2                              |             
      Acinus, Hyperplasia                  |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  A  +  +  +  A  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  A  +  +  +  A  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                2                                                         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  51                                                               
NTP Experiment-Test: 05020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:22:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 4| 6| 7| 7| 6| 7| 6| 6| 7| 7| 6| 7| 5| 7| 7| 5| 6| 6| 5| 5| 6|             
                             DAY ON TEST   | 2| 5| 3| 3| 7| 8| 1| 3| 2| 3| 7| 7| 2| 2| 1| 0| 2| 3| 3| 3| 2| 8| 8| 5| 8|             
                                           | 2| 4| 0| 2| 6| 6| 2| 0| 2| 1| 4| 6| 8| 8| 8| 0| 2| 0| 0| 5| 4| 6| 4| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    18 MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Hyperkeratosis                       |                2                                                         |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  A  +  +  +  A  +  +  +     +  A  A  +  +  +  +  +  +  +  +  +|             
      Necrosis, Coagulative                |                                                 3              2         |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
      Foreign Body                         |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Peridontal Tissue, Foreign Body      |                                                                          |             
      Peridontal Tissue, Inflammation,     |                                                                          |             
           Chronic Active                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesenteric Artery, Inflammation,     |                                                                          |             
           Chronic Active                  |       4                                                                  |             
      Mesenteric Artery, Necrosis,         |                                                                          |             
          Fibrinoid                        |       2                                                                  |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy, Chronic              |    2  2  2  3  2  2     2  2        2  2  2  2     2     1  2     3  2  2|             
      Mineralization                       |                                        1                                 |             
      Atrium, Thrombosis                   |          X                 X                             X  X            |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Degeneration, Fatty                  | 3                             1                 4        2  2           2|             
      Hematocyst                           |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia                          |       2  2     2           2        2                                2   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +     +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia                          |                   2        2  3                 2     2  2  2           1|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | M  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  M|             
      Craniopharyngeal Duct, Cyst          |          X                                                               |             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia           |       2                       2  2  2           2        2        2      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Inflammation, Necrotizing            |             3                                                            |             
      C-Cell, Hyperplasia                  |          2           2     1        2  2        2  2                     |             
      Follicular Cell, Hyperplasia         |          1                                                     2         |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  52                                                               
NTP Experiment-Test: 05020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:22:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 4| 6| 7| 7| 6| 7| 6| 6| 7| 7| 6| 7| 5| 7| 7| 5| 6| 6| 5| 5| 6|             
                             DAY ON TEST   | 2| 5| 3| 3| 7| 8| 1| 3| 2| 3| 7| 7| 2| 2| 1| 0| 2| 3| 3| 3| 2| 8| 8| 5| 8|             
                                           | 2| 4| 0| 2| 6| 6| 2| 0| 2| 1| 4| 6| 8| 8| 8| 0| 2| 0| 0| 5| 4| 6| 4| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    18 MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM - cont                |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                   +      |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 3                                                                       2|             
      Inflammation, Chronic Active         | 3  2  2  2  2  2  2  3  2  2  2  2  2  2  2           2     2  2  2  2  3|             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                   2                                                      |             
      Inflammation, Chronic Active         | 3  1  2  2  2     3     3        1     4     1     2     2  1  1     2   |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |             +     +     +           M     +  +  +        +  +        +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Interstitial Cell, Hyperplasia       | 2  2  2  2     2        2     2     2     2     2        2  2     2  2   |             
      Seminiferous Tubule, Atrophy         | 2  3  3  3     4     3  4  3  3  4  4  4  2  4     4  4  3  4  4  3  2  4|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |       +  +     +  +  +     +        +  +           +     +           +  +|             
      Neutrophilia                         |                                                          X           X   |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |             2                                               2            |             
      Thrombosis                           |                                                                   X      |             
      Femoral, Hyperplasia                 | 3  4  3  3     4  3  4  4  3  3     4  4  4  3  4  4  4  4     3  2  4  4|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +|             
      Mediastinal, Cyst                    |                                                                         X|             
      Mediastinal, Edema                   |                                                                          |             
      Mediastinal, Hemorrhage, Acute       |                               4                                          |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Mast Cell                       |                                                                          |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Histiocyte                      |                                                                          |             
      Mediastinal, Pigmentation,           |                                                                          |             
          Hemosiderin                      |                                                                          |             
      Pancreatic, Ectopic Tissue           |                                                                          |             
      Pancreatic, Infiltration Cellular,   |                                                                          |             
           Histiocyte                      |                                                                          |             
      Pancreatic, Pigmentation, Hemosiderin|                                                                          |             
      Renal, Cyst                          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                    X                    X|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +                          M                                      +  +|             
      Cyst                                 |                                                                      X   |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
      Pigmentation, Hemosiderin            |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  53                                                               
NTP Experiment-Test: 05020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:22:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 4| 6| 7| 7| 6| 7| 6| 6| 7| 7| 6| 7| 5| 7| 7| 5| 6| 6| 5| 5| 6|             
                             DAY ON TEST   | 2| 5| 3| 3| 7| 8| 1| 3| 2| 3| 7| 7| 2| 2| 1| 0| 2| 3| 3| 3| 2| 8| 8| 5| 8|             
                                           | 2| 4| 0| 2| 6| 6| 2| 0| 2| 1| 4| 6| 8| 8| 8| 0| 2| 0| 0| 5| 4| 6| 4| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    18 MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Cyst                                 |                                                                          |             
      Fibrosis                             | 3  2  3  3     2  4  3     4  4  3     4           3  3  3  3  3  3  4  4|             
      Granuloma                            |                                                    1                     |             
      Hematopoietic Cell Proliferation     |                1  2     2        1     1        4  2     3  2  1     2  1|             
      Infarct, Acute                       |                                                                          |             
      Infiltration Cellular, Lipocyte      |    2  1  3        2  3     2     3     3                 2  2        1  3|             
      Pigmentation, Hemosiderin            |       1  2  2  3              1        2        3                 2  2   |             
      Sinusoid, Ectasia                    |    2                                                                     |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  A  +  +  +  +  +  M  M  M  M  +  A  M  +  +  +  +  +  +  +  M|             
      Cyst                                 |                                                       X                  |             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  M  +  +  M  M  +|             
      Hyperplasia, Cystic                  |       1  2     1  2           1  3  2  2        2  4  1        1        1|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                        X                                 |             
      Hydrocephalus                        |                                        2                                 |             
      Mineralization                       |                                  2                                       |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granuloma                            |                                                                          |             
      Inflammation, Chronic                |                         2           1                    2               |             
      Inflammation, Suppurative            |                               2                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Mediastinum, Inflammation, Chronic   |                                                                          |             
          Active                           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  M|             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Suppurative            |                               2                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic Active                  |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                                                 2                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  54                                                               
NTP Experiment-Test: 05020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:22:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 4| 6| 7| 7| 6| 7| 6| 6| 7| 7| 6| 7| 5| 7| 7| 5| 6| 6| 5| 5| 6|             
                             DAY ON TEST   | 2| 5| 3| 3| 7| 8| 1| 3| 2| 3| 7| 7| 2| 2| 1| 0| 2| 3| 3| 3| 2| 8| 8| 5| 8|             
                                           | 2| 4| 0| 2| 6| 6| 2| 0| 2| 1| 4| 6| 8| 8| 8| 0| 2| 0| 0| 5| 4| 6| 4| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    18 MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Necrotizing            |             3                                                            |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     | +                                                                        |             
                                            __________________________________________________________________________|             
   Eye                                     | +     +  +        +  +     +                             +               |             
      Inflammation, Chronic                |                                                                          |             
      Lens, Cataract                       | 3     3  3        3  3     3                             3               |             
      Retina, Atrophy                      | 3     3  3        3  3     3                             4               |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  A  M  +  +  +  +  +  +  +  M|             
      Inflammation, Chronic                |                                           2                              |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy, Chronic                 | 2  2  3  3     2  2  3  2  2  2  2  1  4  2     1  3  3     2  2  2  1  2|             
      Renal Tubule, Pigmentation,          |                                                                          |             
          Hemosiderin                      | 3  2  3  3  2  3  4  2  2  2  3  2  2  3  2  2  2  2  2  2  3  2  1  3  2|             
                                            __________________________________________________________________________|             
   Ureter                                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Urethra                                 |                   +  +        +        +              +           +      |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  A  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                                          |             
      Inflammation, Chronic Active         |       2                                2                                 |             
      Transitional Epithelium, Hyperplasia |                                        2                                 |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  55                                                               
NTP Experiment-Test: 05020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:22:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 4| 6|            |
                             DAY ON TEST   | 3| 3| 3| 5| 2| 3| 3| 2| 3| 3| 7| 2| 1| 2| 3| 5| 2| 2| 3| 3| 9| 1| 3| 1| 8|            |
                                           | 0| 1| 1| 9| 9| 0| 2| 9| 1| 2| 9| 1| 5| 9| 1| 9| 9| 8| 1| 2| 4| 6| 0| 5| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    18 MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Foreign Body                         |                                                                          |      1  4.0|
      Inflammation, Necrotizing            |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  44        |
      Dilatation                           |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Parasite Metazoan                    |                               X                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|  45        |
      Parasite Metazoan                    |                               X                                          |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +     +  +  +  +|  44        |
      Parasite Metazoan                    |                            X           X        X                    X   |      4     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +     +  +  +  A|  39        |
      Dilatation                           |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +     +  +  +  +|  41        |
      Dilatation                           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Basophilic Focus                     | X  X  X  X  X  X  X     X  X  X        X     X                          X|     21     |
      Clear Cell Focus                     |                                                 X                 X      |      2     |
      Degeneration, Cystic                 | 2                    2     2     2                 1  1        2         |     12  1.7|
      Eosinophilic Focus                   |       X                                                                  |      2     |
      Hematopoietic Cell Proliferation     |                                  1                                       |      1  1.0|
      Hepatodiaphragmatic Nodule           |                                  X                                       |      2     |
      Inflammation, Chronic                | 1     1  1           1                    3                              |      9  1.4|
      Inflammation, Necrotizing            |                                                       1                  |      4  1.5|
      Necrosis, Coagulative                |                                  3  3              3        2           3|      9  2.9|
      Pigmentation, Hemosiderin            | 1  2  1     2  1  1  2  1  2           1           1     1     1        1|     26  1.5|
      Vacuolization Cytoplasmic            |                                                    1                     |      1  1.0|
      Bile Duct, Hyperplasia               | 2  2  1  2  2  2  2  2  1  2  3  2  2  2  1  1  2  1  2  2  2  1  1  2  1|     47  1.7|
                                            __________________________________________________________________________|____________|
   Mesentery                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Ectopic Tissue                       |                                                                   X      |      1     |
      Inflammation, Chronic                | 1                       2                                            2   |      5  1.8|
      Pigmentation, Hemosiderin            |                                           3                              |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Inflammation, Chronic                |                                                                   3      |      1  3.0|
      Acinus, Atrophy                      |                   2        1  1  2     2     4  1                 3     1|     13  1.9|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  56                                                               
NTP Experiment-Test: 05020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:22:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 4| 6|            |
                             DAY ON TEST   | 3| 3| 3| 5| 2| 3| 3| 2| 3| 3| 7| 2| 1| 2| 3| 5| 2| 2| 3| 3| 9| 1| 3| 1| 8|            |
                                           | 0| 1| 1| 9| 9| 0| 2| 9| 1| 2| 9| 1| 5| 9| 1| 9| 9| 8| 1| 2| 4| 6| 0| 5| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    18 MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Acinus, Hyperplasia                  |                                                                         2|      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Acanthosis                           |                                                                          |      1  2.0|
      Hyperkeratosis                       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
      Necrosis, Coagulative                |          1                       2                                       |      4  2.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                              +                           |   1        |
      Foreign Body                         |                                              2                           |      1  2.0|
      Inflammation, Chronic Active         |                                              2                           |      1  2.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Peridontal Tissue, Foreign Body      |                                                                   1      |      1  1.0|
      Peridontal Tissue, Inflammation,     |                                                                          |            |
           Chronic Active                  |                         2                                         2      |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mesenteric Artery, Inflammation,     |                                                                          |            |
           Chronic Active                  |                                                                          |      1  4.0|
      Mesenteric Artery, Necrosis,         |                                                                          |            |
          Fibrinoid                        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy, Chronic              | 2  2  3  2  3  2  2  2  2  3  2  2  3  2  2  2  2     2  2  2  2  2  2  2|     42  2.1|
      Mineralization                       |                                                                          |      1  1.0|
      Atrium, Thrombosis                   |                   X           X                                X        X|      8     |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Degeneration, Fatty                  |    2        2  1  1              3     1  1     2     2                 1|     16  1.9|
      Hematocyst                           |                                                                         X|      1     |
      Hematopoietic Cell Proliferation     |                                  2                                       |      1  2.0|
      Hyperplasia                          |    2  1     2        2     2     2     2     1  3        1              2|     17  1.9|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hematopoietic Cell Proliferation     |                                  2                                       |      1  2.0|
      Hyperplasia                          |    2  2  2  2  2        2              2           1                    2|     17  1.9|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  M  +  +  +  +  +|  45        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  57                                                               
NTP Experiment-Test: 05020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:22:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 4| 6|            |
                             DAY ON TEST   | 3| 3| 3| 5| 2| 3| 3| 2| 3| 3| 7| 2| 1| 2| 3| 5| 2| 2| 3| 3| 9| 1| 3| 1| 8|            |
                                           | 0| 1| 1| 9| 9| 0| 2| 9| 1| 2| 9| 1| 5| 9| 1| 9| 9| 8| 1| 2| 4| 6| 0| 5| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    18 MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  46        |
      Craniopharyngeal Duct, Cyst          |                                                                          |      1     |
      Pars Distalis, Cyst                  |                                        X                                 |      1     |
      Pars Distalis, Hyperplasia           |             2           2     1     2     2                       2      |     13  1.9|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  A|  45        |
      Inflammation, Necrotizing            |                                                                          |      1  3.0|
      C-Cell, Hyperplasia                  | 2  2  2  2  1  1     2  1  2           1  2     2     1  1     1  1  2   |     24  1.6|
      Follicular Cell, Hyperplasia         |                                                                          |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hyperplasia                          |                                                          3               |      3  2.7|
      Inflammation, Chronic Active         |    2  2  3  2  2  2  2  2  2     2  2  1  2  2  2  3  2     2  2  2  1  2|     43  2.1|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Abscess                              |                                                                          |      1  2.0|
      Inflammation, Chronic Active         | 2        2  2  2           1  2  2     2              2     2  2  2  2  2|     29  2.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |             +        +  +  +     +  M     +  +     +  +  +  +     +  +   |  23        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Interstitial Cell, Hyperplasia       |          2  1              2  2  2              2        1  2  2  1  2   |     25  1.9|
      Seminiferous Tubule, Atrophy         | 4  4  4  4  4  4  4  4  4  4  4  4  3  4  4  4  4  4  4  4  4  4  4     4|     46  3.7|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   | +  +  +  +  +  +  +  +  +  +        +  +  +  +  +     +  +     +  +      |  31        |
      Neutrophilia                         |          X     X                             X                 X         |      6     |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                                          |      2  2.0|
      Thrombosis                           |                                                                          |      1     |
      Femoral, Hyperplasia                 | 3  3  4  4  3     4  3  4  4  3  4  4  3  4  4  4  4  3  3  4  4  3  3  3|     46  3.5|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Mediastinal, Cyst                    |                   X                                                      |      2     |
      Mediastinal, Edema                   |                         2                                                |      1  2.0|
      Mediastinal, Hemorrhage, Acute       |                                                                          |      1  4.0|
      Mediastinal, Infiltration Cellular,  |                                                                          |            |
           Mast Cell                       |                                                    3                     |      1  3.0|
      Mediastinal, Infiltration Cellular,  |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  58                                                               
NTP Experiment-Test: 05020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:22:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 4| 6|            |
                             DAY ON TEST   | 3| 3| 3| 5| 2| 3| 3| 2| 3| 3| 7| 2| 1| 2| 3| 5| 2| 2| 3| 3| 9| 1| 3| 1| 8|            |
                                           | 0| 1| 1| 9| 9| 0| 2| 9| 1| 2| 9| 1| 5| 9| 1| 9| 9| 8| 1| 2| 4| 6| 0| 5| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    18 MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
           Histiocyte                      |                                           3                              |      1  3.0|
      Mediastinal, Pigmentation,           |                                                                          |            |
          Hemosiderin                      |                                           3                    2         |      2  2.5|
      Pancreatic, Ectopic Tissue           |                                           X                              |      1     |
      Pancreatic, Infiltration Cellular,   |                                                                          |            |
           Histiocyte                      |                                           3                          2   |      2  2.5|
      Pancreatic, Pigmentation, Hemosiderin|                                           3                    2         |      2  2.5|
      Renal, Cyst                          |                X                                                         |      1     |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Cyst                                 |                         X                    X                           |      4     |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +              +                 +     +     +     +                  |  10        |
      Cyst                                 |                                                 X                        |      2     |
      Infiltration Cellular, Histiocyte    |                                           3                              |      1  3.0|
      Pigmentation, Hemosiderin            |                                           2                              |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |    X                                                                     |      1     |
      Fibrosis                             | 3  3  3  3  3  3  3  3  3  3  3  2        3  2  3     2  3  3  3  4  3  3|     41  3.0|
      Granuloma                            |                                                                          |      1  1.0|
      Hematopoietic Cell Proliferation     | 1  1     2                    1  3        1  1  1     2  1  3  2  2  2   |     26  1.7|
      Infarct, Acute                       |                                  4                                       |      1  4.0|
      Infiltration Cellular, Lipocyte      | 3  2     2  3     2  3  3  2           2                       3  2     3|     24  2.4|
      Pigmentation, Hemosiderin            | 2  1     1  1  1  2     2     2                       2  3     2  2      |     21  1.9|
      Sinusoid, Ectasia                    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  M  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  M  M  +  +  M  +|  36        |
      Cyst                                 |                                                                          |      1     |
      Inflammation, Chronic Active         |                                                                3         |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  +  +  M  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  M  +  +  M  M|  36        |
      Hyperplasia, Cystic                  |    1  2     1  2  1  1  2     2     2  2     1     2  2  2     1  2      |     29  1.7|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          |                                                                          |      1     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  59                                                               
NTP Experiment-Test: 05020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:22:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 4| 6|            |
                             DAY ON TEST   | 3| 3| 3| 5| 2| 3| 3| 2| 3| 3| 7| 2| 1| 2| 3| 5| 2| 2| 3| 3| 9| 1| 3| 1| 8|            |
                                           | 0| 1| 1| 9| 9| 0| 2| 9| 1| 2| 9| 1| 5| 9| 1| 9| 9| 8| 1| 2| 4| 6| 0| 5| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    18 MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Hydrocephalus                        | 3                                                                        |      2  2.5|
      Mineralization                       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                      +   |   1        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                      +   |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Granuloma                            |                                                                      1   |      1  1.0|
      Inflammation, Chronic                |                      1                                                   |      4  1.5|
      Inflammation, Suppurative            |                                              2                           |      2  2.0|
      Alveolar Epithelium, Hyperplasia     |                3                       2                                 |      2  2.5|
      Mediastinum, Inflammation, Chronic   |                                                                          |            |
          Active                           |                                                                3         |      1  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|  46        |
      Inflammation, Chronic Active         |       2  2     2     2  2     2                    1                 2   |      8  1.9|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Chronic Active                  |                                                                   3      |      1  3.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     | 1                                2                                       |      3  1.7|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Necrotizing            |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     |    +        +        +  +  +           +                 +               |  14        |
      Inflammation, Chronic                |                                                          2               |      1  2.0|
      Lens, Cataract                       |    3        4        3  3  3           3                                 |     13  3.1|
      Retina, Atrophy                      |    3        4        3  3  3           3                                 |     13  3.2|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +|  43        |
      Inflammation, Chronic                |             2                                                  1         |      3  1.7|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Nephropathy, Chronic                 | 3  3  3  2  3  3  3  2  2  3  3  2  1  3  2  2  2  2  3  2     2  3  1  2|     46  2.3|
      Renal Tubule, Pigmentation,          |                                                                          |            |
          Hemosiderin                      | 2  3  2  3  3  2  2  2  2  2  2  2  1  3  2  2  2  2  2  2  2  2  2  2  2|     50  2.2|
                                            __________________________________________________________________________|____________|
   Ureter                                  | +  +     +  +  +  +  +  +  +     +     +  +  +  +  +  +  +  +     +  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Urethra                                 | +        +        +                    +                       +         |  11        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  60                                                               
NTP Experiment-Test: 05020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:22:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 4| 6|            |
                             DAY ON TEST   | 3| 3| 3| 5| 2| 3| 3| 2| 3| 3| 7| 2| 1| 2| 3| 5| 2| 2| 3| 3| 9| 1| 3| 1| 8|            |
                                           | 0| 1| 1| 9| 9| 0| 2| 9| 1| 2| 9| 1| 5| 9| 1| 9| 9| 8| 1| 2| 4| 6| 0| 5| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    18 MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Dilatation                           |                                                          4               |      1  4.0|
      Inflammation, Chronic Active         |                                                                          |      2  2.0|
      Transitional Epithelium, Hyperplasia |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  61                                                               
NTP Experiment-Test: 05020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:22:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 5|             
                             DAY ON TEST   | 6| 1| 2| 3| 2| 3| 2| 3| 3| 2| 4| 7| 1| 2| 2| 2| 3| 3| 2| 3| 3| 3| 3| 2| 7|             
                                           | 1| 6| 9| 0| 9| 0| 9| 2| 2| 9| 9| 6| 0| 9| 4| 9| 1| 1| 9| 2| 1| 1| 3| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    6 MG/KG                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +                             +  +        +     +                 +  +  +|             
      Foreign Body                         |                                                                   4      |             
      Inflammation, Necrotizing            |                                  3                                       |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +                             +  +                                +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +                             +  A                                A  M  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +                             +  A                                A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | M                             A  +                                +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +                             +  +                                +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +                             +  A                                +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +                             +  A                                A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +                             A  +                                A  +  +|             
      Metaplasia, Osseous                  |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |    2                                                                     |             
      Basophilic Focus                     |       X  X           X  X           X  X  X     X  X  X     X  X        X|             
      Degeneration, Cystic                 |    4        2              2  1     2     3        2                     |             
      Eosinophilic Focus                   |                            X                                             |             
      Hepatodiaphragmatic Nodule           |                            X                                             |             
      Inflammation, Chronic                | 2                             1     2  2        1  2  3  2               |             
      Inflammation, Necrotizing            |    1                    1                                4               |             
      Necrosis, Coagulative                |                   2                       4                              |             
      Vacuolization Cytoplasmic            |    2           1                                         1  2            |             
      Bile Duct, Hyperplasia               | 2  2  2  2  1  2  2  2  2  2  2  3  1  2  2  2  2  2  2  2  3  2  2     2|             
                                            __________________________________________________________________________|             
   Mesentery                               | +  +                          +                                      +  +|             
      Inflammation, Chronic                |    2                          1                                          |             
      Pigmentation, Hemosiderin            |    3                                                                     |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +                    +     +  A              +                 +  +  +|             
      Pigmentation, Hemosiderin            |    2                                                                     |             
      Acinus, Atrophy                      | 2                                                                       1|             
      Acinus, Hyperplasia                  |    2                                                                     |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +                             +  A        +                       +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +                          +  A                                +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +                          +  A                                +  +  +|             
      Acanthosis                           |                                                                      2   |             
      Hyperkeratosis                       |                                                                      2   |             
      Inflammation, Chronic Active         |    4                                                                 2   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +                          +  A                                +  +  +|             
      Inflammation, Chronic Active         |    4                                                                     |             
                                            __________________________________________________________________________|             
   Tooth                                   | +                             +  +                                +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +                             +  +        +                       +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +     +  +           +     +  +        +     +              +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  62                                                               
NTP Experiment-Test: 05020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:22:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 5|             
                             DAY ON TEST   | 6| 1| 2| 3| 2| 3| 2| 3| 3| 2| 4| 7| 1| 2| 2| 2| 3| 3| 2| 3| 3| 3| 3| 2| 7|             
                                           | 1| 6| 9| 0| 9| 0| 9| 2| 2| 9| 9| 6| 0| 9| 4| 9| 1| 1| 9| 2| 1| 1| 3| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    6 MG/KG                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Cardiomyopathy, Chronic              |    2     2  2           2     2  3        2     2              2  2  2  3|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Fatty                  |                         2           2                    1               |             
      Hyperplasia                          |                         2  1        2        2           2  2     2      |             
      Necrosis, Coagulative                |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |       X                                                                  |             
      Hyperplasia                          |    2           2        2  1              2        2     2              2|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +                             +  A                                +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +                             +  M                                +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +        +              +  +  A  +                             +  +  +|             
      Pars Distalis, Angiectasis           |             3                                                            |             
      Pars Distalis, Hemorrhage, Acute     |                                                                         3|             
      Pars Distalis, Hyperplasia           |                            2                                             |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +                             +  A                                +  +  +|             
      C-Cell, Hyperplasia                  |                                                                      2  1|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +        +           +     +  +                                +  +  +|             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                          |             
      Concretion                           |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +     +        +        +  +  +  +                                +  +  +|             
      Hyperplasia                          |                         4                                                |             
      Inflammation, Chronic Active         | 2     4                                                           2  2  2|             
                                            __________________________________________________________________________|             
   Prostate                                | +           +                 +  +                                +  +  +|             
      Inflammation, Chronic Active         |             4                 2  2                                3  2  2|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Interstitial Cell, Hyperplasia       | 2           2           1     2  2                                2  2  1|             
      Seminiferous Tubule, Atrophy         |    4  4  4  4  4  4  4  4  3        3  3  4  4  4  4  4     4  4         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   | +  +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +         |             
      Neutrophilia                         |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Femoral, Hyperplasia                 | 4  2  4  3  3  3  3  4  4  3                 3  4  3  3     3  3  3  4  3|             
      Femoral, Hyperplasia, Reticulum Cell |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  63                                                               
NTP Experiment-Test: 05020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:22:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 5|             
                             DAY ON TEST   | 6| 1| 2| 3| 2| 3| 2| 3| 3| 2| 4| 7| 1| 2| 2| 2| 3| 3| 2| 3| 3| 3| 3| 2| 7|             
                                           | 1| 6| 9| 0| 9| 0| 9| 2| 2| 9| 9| 6| 0| 9| 4| 9| 1| 1| 9| 2| 1| 1| 3| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    6 MG/KG                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +                             +  +        +     +                 +  +  +|             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Mast Cell                       |                                           2                              |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +                             +  A        +                       +  +  +|             
      Ectasia                              |                                           2                              |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                                                                      +   |             
      Cyst                                 |                                                                          |             
      Ectasia                              |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                   1        1        1                       2  1  2      |             
      Hematopoietic Cell Proliferation     | 2  2  2  2  2  2  2  1  2  2  2     3  2  3  2     2  2  2  2  2     3  2|             
      Pigmentation, Hemosiderin            |    1  3  3  2  3  3  3  2  3  2  2  3  2  2  2  2  2  2  2  3  2  3  1  3|             
                                            __________________________________________________________________________|             
   Thymus                                  | +                       +     +  +        +     +                 M  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M     +              +  +  +  +  +           +                    +  +  +|             
      Hyperplasia, Cystic                  |       2                    4  2  2                                2  2  2|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +              +  +  +  +  +           +                    +  +  +|             
      Inflammation, Chronic Active         |       4                                                                  |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         | +                             +  +                                +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +                             +  A                                +  +  +|             
      Compression                          |                                                                   X     X|             
      Hemorrhage, Acute                    |                                                                         4|             
      Hydrocephalus                        |                                                                         2|             
                                            __________________________________________________________________________|             
   Spinal Cord                             | +                                                                        |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +                                +                                +  +  +|             
                                            __________________________________________________________________________|             
   Nose                                    | +                             +  +                                +  +  +|             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                                                                      2   |             
                                            __________________________________________________________________________|             
   Trachea                                 | +                             +  +        +     +                 +  +  +|             
      Inflammation, Necrotizing            |                                  3                                       |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |          +  +  +     +  +  +                             +               |             
      Lens, Cataract                       |          3  3  3     3  3  3                                             |             
      Retina, Atrophy                      |          3  3  3     3  3  3                             3               |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +                             +  +                                +  +  M|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  64                                                               
NTP Experiment-Test: 05020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:22:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 5|             
                             DAY ON TEST   | 6| 1| 2| 3| 2| 3| 2| 3| 3| 2| 4| 7| 1| 2| 2| 2| 3| 3| 2| 3| 3| 3| 3| 2| 7|             
                                           | 1| 6| 9| 0| 9| 0| 9| 2| 2| 9| 9| 6| 0| 9| 4| 9| 1| 1| 9| 2| 1| 1| 3| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    6 MG/KG                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy, Chronic                 | 1  4  3  2  3  2  3  3  2  4  2  2  3  2  3  3  2  3  3  3  3  3  3  2  2|             
      Renal Tubule, Pigmentation,          |                                                                          |             
          Hemosiderin                      | 1  3  2  2  2  2  2  2  2  2  1     2  2  2  2  2  2  2  2  2  2  1  1  1|             
                                            __________________________________________________________________________|             
   Ureter                                  | +           +  +     +  +     +  +  +        +     +        +     +  +   |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                                   +      |             
      Transitional Epithelium, Hyperplasia |                                                                   3      |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +           +                 +  +                                +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  65                                                               
NTP Experiment-Test: 05020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:22:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 3| 7| 4| 7| 4|            |
                             DAY ON TEST   | 3| 3| 3| 7| 8| 1| 3| 0| 3| 3| 3| 3| 3| 3| 2| 3| 3| 7| 3| 1| 3| 2| 7| 3| 9|            |
                                           | 2| 2| 0| 8| 6| 8| 2| 2| 0| 1| 2| 1| 2| 2| 9| 2| 2| 0| 1| 1| 8| 9| 6| 2| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    6 MG/KG                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |          +                                         +        +     +     +|  13        |
      Foreign Body                         |          4                                                               |      2  4.0|
      Inflammation, Necrotizing            |                                                                   4      |      2  3.5|
                                            __________________________________________________________________________|____________|
   Intestine Large                         |          +                 +                       +        +     +     +|  12        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |          +                 +                       A        A     A     +|   6        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |          +                                         +        +     +     +|   9        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |          +                                         A        +     +     +|   8        |
      Parasite Metazoan                    |          X                                                               |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |          +  +                                      +        +     +     +|  12        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |          +                                         +        +     +     +|  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |          A                                         A        +     A     +|   6        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |          +  +                                      A        +     A     +|   8        |
      Metaplasia, Osseous                  |             2                                                            |      1  2.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Angiectasis                          |                         2                                                |      2  2.0|
      Basophilic Focus                     | X  X  X  X     X  X     X  X  X  X  X        X  X     X  X     X  X  X   |     31     |
      Degeneration, Cystic                 |                2                             3                       2   |     10  2.3|
      Eosinophilic Focus                   |                                                                          |      1     |
      Hepatodiaphragmatic Nodule           |                                     X                                    |      2     |
      Inflammation, Chronic                | 2  2  2  2              1           2  2        1  1  2              2   |     19  1.8|
      Inflammation, Necrotizing            |                            1                                2            |      5  1.8|
      Necrosis, Coagulative                |                                                                         2|      3  2.7|
      Vacuolization Cytoplasmic            |                      1        1              1  2        2               |      9  1.4|
      Bile Duct, Hyperplasia               |    2  2        2  2  2  2  2  2  2  2  2  2  2  2  2  1        2     2  3|     43  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |          +           +                             +        +     +     +|  11        |
      Inflammation, Chronic                |                                                                          |      2  1.5|
      Pigmentation, Hemosiderin            |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                |          +           +                             +        +     +     +|  14        |
      Pigmentation, Hemosiderin            |                                                                          |      1  2.0|
      Acinus, Atrophy                      |                                                    2                     |      3  1.7|
      Acinus, Hyperplasia                  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |          +                                         +        +     +     +|  11        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |          +                                         +        +     +     +|  11        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |          +                                         +        +     +     +|  11        |
      Acanthosis                           |                                                                          |      1  2.0|
      Hyperkeratosis                       |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |          +                                         +        +     +     +|  11        |
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  66                                                               
NTP Experiment-Test: 05020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:22:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 3| 7| 4| 7| 4|            |
                             DAY ON TEST   | 3| 3| 3| 7| 8| 1| 3| 0| 3| 3| 3| 3| 3| 3| 2| 3| 3| 7| 3| 1| 3| 2| 7| 3| 9|            |
                                           | 2| 2| 0| 8| 6| 8| 2| 2| 0| 1| 2| 1| 2| 2| 9| 2| 2| 0| 1| 1| 8| 9| 6| 2| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    6 MG/KG                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                    +        +     +     +|  10        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |          +                                         +        +     +     +|  12        |
                                            __________________________________________________________________________|____________|
   Heart                                   |          +     +  +           +           +  +     +        +     +     +|  23        |
      Cardiomyopathy, Chronic              |          2     2  2           2           2  2     2        2     3     2|     22  2.1|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Degeneration, Fatty                  |    2           2  1        2                          3  2           2   |     10  1.9|
      Hyperplasia                          | 1  2     2     2        2  1  2        2        2     2  2           2   |     19  1.8|
      Necrosis, Coagulative                |                                                                         2|      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|  48        |
      Cyst                                 |                                                                          |      1     |
      Hyperplasia                          |                2  2              1  2     2     2              2         |     15  1.9|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |          +                                         +        +     +     +|  10        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |          +                                         +        +     +     +|  10        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |          +     +  +                    +        +  +     +  +     +     +|  19        |
      Pars Distalis, Angiectasis           |                                                                          |      1  3.0|
      Pars Distalis, Hemorrhage, Acute     |                                                                          |      1  3.0|
      Pars Distalis, Hyperplasia           |                                        2                                 |      2  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |          +                                         +        +     +     +|  10        |
      C-Cell, Hyperplasia                  |          2                                                              2|      4  1.8|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |          +     +        +  +     +  +  +  +  +     +  +  +  +  +  +  +  +|  26        |
                                            __________________________________________________________________________|____________|
   Penis                                   |                                                                         +|   1        |
      Concretion                           |                                                                         3|      1  3.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |          +                                         M        +  +  +     +|  15        |
      Hyperplasia                          |                                                                          |      1  4.0|
      Inflammation, Chronic Active         |          2                                                              2|      7  2.3|
                                            __________________________________________________________________________|____________|
   Prostate                                |          +           +                             +        +     +     +|  13        |
      Inflammation, Chronic Active         |          2                                         1        2     2     2|     11  2.2|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |          +           +                             +              +     +|   5        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  67                                                               
NTP Experiment-Test: 05020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:22:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 3| 7| 4| 7| 4|            |
                             DAY ON TEST   | 3| 3| 3| 7| 8| 1| 3| 0| 3| 3| 3| 3| 3| 3| 2| 3| 3| 7| 3| 1| 3| 2| 7| 3| 9|            |
                                           | 2| 2| 0| 8| 6| 8| 2| 2| 0| 1| 2| 1| 2| 2| 9| 2| 2| 0| 1| 1| 8| 9| 6| 2| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    6 MG/KG                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Interstitial Cell, Hyperplasia       | 2     2  2        2        2  2  2  1  1     2     2     1     2  2  2   |     23  1.8|
      Seminiferous Tubule, Atrophy         | 4  4  4     4  4  4  4  4  2  4  4  4  4  4  4  4  2  4  4     4     4   |     39  3.8|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   | +  +  +        +  +  +  +  +  +  +  +  +  +  +  +     +  +     +     +  +|  39        |
      Neutrophilia                         |                      X                                                   |      1     |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |                   2                                                      |      1  2.0|
      Femoral, Hyperplasia                 | 3  3  3              4  3  3  3  3  2  3  3  2  2     4        3        4|     35  3.1|
      Femoral, Hyperplasia, Reticulum Cell | 3  2                                                  2                  |      3  2.3|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |          +        +        +                       +        +     +     +|  15        |
      Mediastinal, Infiltration Cellular,  |                                                                          |            |
           Mast Cell                       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |          +        +                                +        +     +     +|  12        |
      Ectasia                              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                            +                                             |   2        |
      Cyst                                 |                            X                                             |      1     |
      Ectasia                              |                            3                                             |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             |    1     3     2        1              1                             1   |     12  1.4|
      Hematopoietic Cell Proliferation     | 2  2  2  2     2  2  4  2     2  2  1  2  2  2  2  2  2  3     3     2   |     42  2.1|
      Pigmentation, Hemosiderin            | 2  2  2  2  2  3  2     2  2  2  2  2  2  2  2  2  2  2  2  3  2  2  2  1|     48  2.2|
                                            __________________________________________________________________________|____________|
   Thymus                                  |          +                                         +        +     +     +|  13        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |          M                                         +        +     +     M|  13        |
      Hyperplasia, Cystic                  |                                                    2        2     2      |     10  2.2|
                                            __________________________________________________________________________|____________|
   Skin                                    |       +  +                                         +     +  +     +     +|  19        |
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |          +                                         +        +     +     +|  11        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |          +                                         +        +     +     +|  10        |
      Compression                          |                                                                          |      2     |
      Hemorrhage, Acute                    |                                                                          |      1  4.0|
      Hydrocephalus                        |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  68                                                               
NTP Experiment-Test: 05020-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         PARA-CHLOROANILINE                                    Date: 05/05/97  
Route: GAVAGE                                                                                                     Time: 13:22:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 3| 7| 4| 7| 4|            |
                             DAY ON TEST   | 3| 3| 3| 7| 8| 1| 3| 0| 3| 3| 3| 3| 3| 3| 2| 3| 3| 7| 3| 1| 3| 2| 7| 3| 9|            |
                                           | 2| 2| 0| 8| 6| 8| 2| 2| 0| 1| 2| 1| 2| 2| 9| 2| 2| 0| 1| 1| 8| 9| 6| 2| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    6 MG/KG                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                             +            |   2        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |          +     +                                   +        +     +     +|  11        |
                                            __________________________________________________________________________|____________|
   Nose                                    |          M                                         +        +     +     +|  10        |
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 |          +                                         +        +     +     +|  13        |
      Inflammation, Necrotizing            |                                                                   3      |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |    +  +              +  +  +                                   +         |  13        |
      Lens, Cataract                       |    3  3              3  3  3                                   3         |     12  3.0|
      Retina, Atrophy                      |    3  3              3  3  3                                   3         |     13  3.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                    +        +     +     +|   9        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Nephropathy, Chronic                 | 3  3  3  2     4  4  3  3  3  4  2  2  3  3  3  4  2  3  4     4  2  4  3|     48  2.9|
      Renal Tubule, Pigmentation,          |                                                                          |            |
          Hemosiderin                      | 2  2  2  1     2  2  2  2  2  2  2  2  2  2  2  2  1  2  2     2  1  1  2|     47  1.8|
                                            __________________________________________________________________________|____________|
   Ureter                                  |       +  +     +     +        +  +     +  +        +     +  +  +  +     +|  27        |
                                            __________________________________________________________________________|____________|
   Urethra                                 |                                                                          |   1        |
      Transitional Epithelium, Hyperplasia |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |          +                                         +        +     +     +|  12        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  69                                                               
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